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Aliases for DBF4B Gene

Aliases for DBF4B Gene

  • DBF4 Zinc Finger B 2 3 5
  • Zinc Finger, DBF-Type Containing 1B 2 3
  • Dbf4-Related Factor 1 3 4
  • ASK-Like Protein 1 3 4
  • Chiffon Homolog B 3 4
  • ASKL1 3 4
  • DRF1 3 4
  • Activator Of S-Phase Kinase-Like Protein 1 3
  • Activator Of S Phase Kinase-Like Protein 1 4
  • Chiffon Homolog B (Drosophila) 2
  • DBF4 Homolog B (S. Cerevisiae) 2
  • Protein DBF4 Homolog B 3
  • DBF4 Homolog B 3
  • ZDBF1B 3
  • CHIFB 3

External Ids for DBF4B Gene

Previous GeneCards Identifiers for DBF4B Gene

  • GC17P040142
  • GC17P042785
  • GC17P038551

Summaries for DBF4B Gene

Entrez Gene Summary for DBF4B Gene

  • This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

GeneCards Summary for DBF4B Gene

DBF4B (DBF4 Zinc Finger B) is a Protein Coding gene. Among its related pathways are E2F mediated regulation of DNA replication. Gene Ontology (GO) annotations related to this gene include nucleic acid binding and protein kinase activator activity. An important paralog of this gene is DBF4.

UniProtKB/Swiss-Prot for DBF4B Gene

  • Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at Ser-40 and then is involved in regulating the initiation of DNA replication during cell cycle.

Additional gene information for DBF4B Gene

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBF4B Gene

Genomics for DBF4B Gene

GeneHancer (GH) Regulatory Elements for DBF4B Gene

Promoters and enhancers for DBF4B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH17I044707 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 599 +0.1 59 2.3 HDGF PKNOX1 SMAD1 FOXA2 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 DBF4B TMUB2 ASB16-AS1 ENSG00000224505 EFTUD2 UBTF C17orf53 MAP3K14-AS1 HEXIM1 MAP3K14
GH17I044687 Promoter/Enhancer 2.1 EPDnew Ensembl ENCODE 36.4 -19.2 -19169 3.7 CLOCK FOXA2 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 IRF4 CCDC43 ENSG00000279879 DBF4B TMUB2 UBTF ASB16-AS1 GPATCH8 ENSG00000224505 ENSG00000260793 MEIOC
GH17I044774 Promoter/Enhancer 1.5 Ensembl ENCODE 28.6 +66.8 66840 2.1 HDGF PKNOX1 ARID4B SIN3A ZNF2 YY1 ZNF207 ZNF143 DEK SP3 DBF4B GJC1 C1QL1 FAM187A EFTUD2 ENSG00000267505 GC17P044768 ADAM11
GH17I044197 Promoter/Enhancer 2.6 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 13.4 -509.2 -509233 4.3 HDGF PKNOX1 ARID4B SIN3A FEZF1 DMAP1 SLC30A9 POLR2B ZNF766 ZNF143 ATXN7L3 ENSG00000267394 GC17M044204 LOC101926967 PIR47424 DBF4B ASB16-AS1 DCAKD UBTF DHX8
GH17I044554 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 12.4 -150.4 -150373 6.5 HDGF PKNOX1 CLOCK ARNT SIN3A FEZF1 ZBTB7B ZNF143 FOS KLF13 FZD2 GC17M044558 DBF4B C17orf53 MPP2 EFTUD2 UBTF MAP3K14-AS1 LRRC37A4P GRN
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around DBF4B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the DBF4B gene promoter:

Genomic Locations for DBF4B Gene

Genomic Locations for DBF4B Gene
chr17:44,708,608-44,758,852
(GRCh38/hg38)
Size:
50,245 bases
Orientation:
Plus strand
chr17:42,785,976-42,829,637
(GRCh37/hg19)

Genomic View for DBF4B Gene

Genes around DBF4B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBF4B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBF4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBF4B Gene

Proteins for DBF4B Gene

  • Protein details for DBF4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFT6-DBF4B_HUMAN
    Recommended name:
    Protein DBF4 homolog B
    Protein Accession:
    Q8NFT6
    Secondary Accessions:
    • D3DX56
    • Q8TEX0
    • Q96B19
    • Q9H912

    Protein attributes for DBF4B Gene

    Size:
    615 amino acids
    Molecular mass:
    67243 Da
    Quaternary structure:
    • Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4/DBF4A or DBF4B. Such complexes are stable upon replication stress.

    Alternative splice isoforms for DBF4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DBF4B Gene

Post-translational modifications for DBF4B Gene

No data available for DME Specific Peptides for DBF4B Gene

Domains & Families for DBF4B Gene

Gene Families for DBF4B Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DBF4B Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DBF4B: view

No data available for UniProtKB/Swiss-Prot for DBF4B Gene

Function for DBF4B Gene

Molecular function for DBF4B Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at Ser-40 and then is involved in regulating the initiation of DNA replication during cell cycle.

Phenotypes From GWAS Catalog for DBF4B Gene

Gene Ontology (GO) - Molecular Function for DBF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0019901 protein kinase binding IPI 12065429
GO:0030295 protein kinase activator activity IDA 12065429
genes like me logo Genes that share ontologies with DBF4B: view

Phenotypes for DBF4B Gene

GenomeRNAi human phenotypes for DBF4B:
genes like me logo Genes that share phenotypes with DBF4B: view

Animal Model Products

CRISPR Products

miRNA for DBF4B Gene

miRTarBase miRNAs that target DBF4B

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DBF4B Gene

Localization for DBF4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBF4B Gene

Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBF4B gene
Compartment Confidence
nucleus 5
cytosol 2

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for DBF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 NOT nuclear chromatin IDA 15668232
GO:0005634 nucleus IEA,IDA 12065429
GO:0005654 nucleoplasm IDA 15668232
GO:0005737 cytoplasm IDA 15668232
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with DBF4B: view

Pathways & Interactions for DBF4B Gene

genes like me logo Genes that share pathways with DBF4B: view

Pathways by source for DBF4B Gene

1 GeneGo (Thomson Reuters) pathway for DBF4B Gene

Gene Ontology (GO) - Biological Process for DBF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0008284 positive regulation of cell proliferation IMP 15668232
GO:0010571 positive regulation of nuclear cell cycle DNA replication IMP 15668232
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP 15668232
GO:0032147 activation of protein kinase activity IEA --
genes like me logo Genes that share ontologies with DBF4B: view

No data available for SIGNOR curated interactions for DBF4B Gene

Drugs & Compounds for DBF4B Gene

No Compound Related Data Available

Transcripts for DBF4B Gene

Unigene Clusters for DBF4B Gene

DBF4 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBF4B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - - -
SP7:
SP8: -
SP9:

ExUns: 14b · 14c ^ 15a · 15b ^ 16
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -

Relevant External Links for DBF4B Gene

GeneLoc Exon Structure for
DBF4B
ECgene alternative splicing isoforms for
DBF4B

Expression for DBF4B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DBF4B Gene

mRNA differential expression in normal tissues according to GTEx for DBF4B Gene

This gene is overexpressed in Testis (x5.0).

Protein differential expression in normal tissues from HIPED for DBF4B Gene

This gene is overexpressed in Blymphocyte (20.3), Breast (16.7), Bone marrow stromal cell (10.7), and Heart (8.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DBF4B Gene



NURSA nuclear receptor signaling pathways regulating expression of DBF4B Gene:

DBF4B

SOURCE GeneReport for Unigene cluster for DBF4B Gene:

Hs.369998

mRNA Expression by UniProt/SwissProt for DBF4B Gene:

Q8NFT6-DBF4B_HUMAN
Tissue specificity: Widely expressed. Highly expressed in testis.

Evidence on tissue expression from TISSUES for DBF4B Gene

  • Lung(4.1)
genes like me logo Genes that share expression patterns with DBF4B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for DBF4B Gene

Orthologs for DBF4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for DBF4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBF4B 33 34
  • 99.29 (n)
dog
(Canis familiaris)
Mammalia DBF4B 33 34
  • 83.08 (n)
cow
(Bos Taurus)
Mammalia DBF4B 33 34
  • 81.84 (n)
oppossum
(Monodelphis domestica)
Mammalia DBF4B 34
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DBF4B 34
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBF4B 34
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii DBF4B 34
  • 13 (a)
OneToOne
Species where no ortholog for DBF4B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBF4B Gene

ENSEMBL:
Gene Tree for DBF4B (if available)
TreeFam:
Gene Tree for DBF4B (if available)

Paralogs for DBF4B Gene

Paralogs for DBF4B Gene

genes like me logo Genes that share paralogs with DBF4B: view

Variants for DBF4B Gene

Sequence variations from dbSNP and Humsavar for DBF4B Gene

SNP ID Clin Chr 17 pos Variation AA Info Type
rs1000081163 -- 44,708,737(+) T/C 5_prime_UTR_variant, genic_upstream_transcript_variant, non_coding_transcript_variant, upstream_transcript_variant
rs1000131807 -- 44,713,653(+) AAACAAACAAACAAA/AAACAAACAAA intron_variant
rs1000189883 -- 44,720,863(+) GCTTTTTTTTT/ intron_variant
rs1000220902 -- 44,752,534(+) C/G 3_prime_UTR_variant, downstream_transcript_variant, genic_downstream_transcript_variant, non_coding_transcript_variant
rs1000222818 -- 44,721,215(+) TT/TTT intron_variant

Structural Variations from Database of Genomic Variants (DGV) for DBF4B Gene

Variant ID Type Subtype PubMed ID
esv2663784 CNV deletion 23128226
esv2671681 CNV deletion 23128226
esv3640653 CNV loss 21293372
esv3640654 CNV loss 21293372
esv3893016 CNV loss 25118596
nsv1067206 CNV gain 25217958
nsv111783 CNV deletion 16902084
nsv1146669 OTHER inversion 26484159
nsv471890 CNV novel sequence insertion 20440878
nsv833456 CNV gain+loss 17160897
nsv960113 CNV duplication 23825009

Variation tolerance for DBF4B Gene

Residual Variation Intolerance Score: 67.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.53; 64.73% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for DBF4B Gene

Human Gene Mutation Database (HGMD)
DBF4B
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBF4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBF4B Gene

Disorders for DBF4B Gene

Additional Disease Information for DBF4B

No disorders were found for DBF4B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBF4B Gene

Publications for DBF4B Gene

  1. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. (PMID: 15668232) Yoshizawa-Sugata N … Masai H (The Journal of biological chemistry 2005) 2 3 4 22 58
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  3. Drf1, a novel regulatory subunit for human Cdc7 kinase. (PMID: 12065429) Montagnoli A … Santocanale C (The EMBO journal 2002) 3 4 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. Interaction of amyotrophic lateral sclerosis/frontotemporal lobar degeneration-associated fused-in-sarcoma with proteins involved in metabolic and protein degradation pathways. (PMID: 25192599) Wang T … Xu J (Neurobiology of aging 2015) 3 58

Products for DBF4B Gene

Sources for DBF4B Gene

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