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Aliases for DBF4B Gene

Aliases for DBF4B Gene

  • DBF4 Zinc Finger B 2 3
  • ASKL1 3 4 6
  • DRF1 3 4 6
  • Dbf4-Related Factor 1 3 4
  • ASK-Like Protein 1 3 4
  • Chiffon Homolog B 3 4
  • Activator Of S-Phase Kinase-Like Protein 1 3
  • Activator Of S Phase Kinase-Like Protein 1 4
  • Zinc Finger, DBF-Type Containing 1B 3
  • Chiffon Homolog B (Drosophila) 2
  • DBF4 Homolog B (S. Cerevisiae) 2
  • DBF-Type Containing 1B 2
  • Protein DBF4 Homolog B 3
  • DBF4 Homolog B 3
  • Zinc Finger 2
  • ZDBF1B 3
  • CHIFB 3

External Ids for DBF4B Gene

Previous GeneCards Identifiers for DBF4B Gene

  • GC17P040142
  • GC17P042785
  • GC17P038551

Summaries for DBF4B Gene

Entrez Gene Summary for DBF4B Gene

  • This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2010]

GeneCards Summary for DBF4B Gene

DBF4B (DBF4 Zinc Finger B) is a Protein Coding gene. Among its related pathways are E2F mediated regulation of DNA replication. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is DBF4.

UniProtKB/Swiss-Prot for DBF4B Gene

  • Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at Ser-40 and then is involved in regulating the initiation of DNA replication during cell cycle.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBF4B Gene

Genomics for DBF4B Gene

Regulatory Elements for DBF4B Gene

Genomic Location for DBF4B Gene

Start:
44,691,254 bp from pter
End:
44,758,412 bp from pter
Size:
67,159 bases
Orientation:
Plus strand

Genomic View for DBF4B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DBF4B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBF4B Gene

Proteins for DBF4B Gene

  • Protein details for DBF4B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NFT6-DBF4B_HUMAN
    Recommended name:
    Protein DBF4 homolog B
    Protein Accession:
    Q8NFT6
    Secondary Accessions:
    • D3DX56
    • Q8TEX0
    • Q96B19
    • Q9H912

    Protein attributes for DBF4B Gene

    Size:
    615 amino acids
    Molecular mass:
    67243 Da
    Quaternary structure:
    • Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4/DBF4A or DBF4B. Such complexes are stable upon replication stress

    Alternative splice isoforms for DBF4B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DBF4B Gene

Proteomics data for DBF4B Gene at MOPED

Post-translational modifications for DBF4B Gene

Other Protein References for DBF4B Gene

No data available for DME Specific Peptides for DBF4B Gene

Domains for DBF4B Gene

Gene Families for DBF4B Gene

HGNC:
  • ZDBF :Zinc fingers, DBF-type

Protein Domains for DBF4B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NFT6

UniProtKB/Swiss-Prot:

DBF4B_HUMAN :
  • Q8NFT6
Domain:
  • Contains 1 BRCT domain.
Similarity:
  • Contains 1 DBF4-type zinc finger.
genes like me logo Genes that share domains with DBF4B: view

Function for DBF4B Gene

Molecular function for DBF4B Gene

UniProtKB/Swiss-Prot Function: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B selectively phosphorylates MCM2 subunit at Ser-40 and then is involved in regulating the initiation of DNA replication during cell cycle.

Gene Ontology (GO) - Molecular Function for DBF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008270 zinc ion binding IEA --
GO:0019901 protein kinase binding IPI 12065429
GO:0030295 protein kinase activator activity IDA 12065429
genes like me logo Genes that share ontologies with DBF4B: view

Animal Model Products

CRISPR Products

miRNA for DBF4B Gene

miRTarBase miRNAs that target DBF4B

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DBF4B Gene

Localization for DBF4B Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBF4B Gene

Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound fraction.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DBF4B Gene COMPARTMENTS Subcellular localization image for DBF4B gene
Compartment Confidence
nucleus 5
cytosol 2

Gene Ontology (GO) - Cellular Components for DBF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 NOT nuclear chromatin IDA 15668232
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 15668232
GO:0016235 aggresome IDA --
genes like me logo Genes that share ontologies with DBF4B: view

Pathways for DBF4B Gene

genes like me logo Genes that share pathways with DBF4B: view

Pathways by source for DBF4B Gene

1 GeneGo (Thomson Reuters) pathway for DBF4B Gene

Gene Ontology (GO) - Biological Process for DBF4B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0008284 positive regulation of cell proliferation IMP 15668232
GO:0010571 positive regulation of nuclear cell cycle DNA replication IMP 15668232
GO:0010971 positive regulation of G2/M transition of mitotic cell cycle IMP 15668232
GO:0045860 positive regulation of protein kinase activity IDA 12065429
genes like me logo Genes that share ontologies with DBF4B: view

Transcripts for DBF4B Gene

Unigene Clusters for DBF4B Gene

DBF4 homolog B (S. cerevisiae):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DBF4B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DBF4B Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a ·
SP1: - - - - -
SP2: - - - - -
SP3: - - - - - -
SP4: - - - -
SP5: - -
SP6: - - - - - - -
SP7:
SP8: -
SP9:

ExUns: 14b · 14c ^ 15a · 15b ^ 16
SP1: - - -
SP2: - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9: -

Relevant External Links for DBF4B Gene

GeneLoc Exon Structure for
DBF4B
ECgene alternative splicing isoforms for
DBF4B

Expression for DBF4B Gene

mRNA expression in normal human tissues for DBF4B Gene

mRNA differential expression in normal tissues according to GTEx for DBF4B Gene

This gene is overexpressed in Testis (5.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DBF4B Gene

SOURCE GeneReport for Unigene cluster for DBF4B Gene Hs.369998

mRNA Expression by UniProt/SwissProt for DBF4B Gene

Q8NFT6-DBF4B_HUMAN
Tissue specificity: Widely expressed. Highly expressed in testis.
genes like me logo Genes that share expressions with DBF4B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DBF4B Gene

Orthologs for DBF4B Gene

This gene was present in the common ancestor of chordates.

Orthologs for DBF4B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBF4B 35
  • 99.29 (n)
  • 98.58 (a)
DBF4B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DBF4B 35
  • 81.84 (n)
  • 76.37 (a)
DBF4B 36
  • 61 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DBF4B 35
  • 83.08 (n)
  • 78.21 (a)
DBF4B 36
  • 69 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DBF4B 36
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DBF4B 36
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DBF4B 36
  • 35 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii DBF4B 36
  • 13 (a)
OneToOne
Species with no ortholog for DBF4B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBF4B Gene

ENSEMBL:
Gene Tree for DBF4B (if available)
TreeFam:
Gene Tree for DBF4B (if available)

Paralogs for DBF4B Gene

Paralogs for DBF4B Gene

genes like me logo Genes that share paralogs with DBF4B: view

Variants for DBF4B Gene

Sequence variations from dbSNP and Humsavar for DBF4B Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs1017062 -- 44,726,292(+) TTttt(A/T)tttat intron-variant
rs1808244 -- 44,732,726(+) CCGAG(C/T)CTGGT intron-variant
rs1814237 -- 44,732,638(+) CAAGG(C/T)GGGTG intron-variant
rs1859857 -- 44,723,784(+) AAATA(A/G)CCTTC intron-variant
rs2041051 -- 44,741,051(+) AATGG(C/T)GTGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DBF4B Gene

Variant ID Type Subtype PubMed ID
nsv908286 CNV Loss 21882294
nsv833456 CNV Gain+Loss 17160897
esv2663784 CNV Deletion 23128226
nsv111783 CNV Loss 16902084
esv2671681 CNV Deletion 23128226

Relevant External Links for DBF4B Gene

HapMap Linkage Disequilibrium report
DBF4B
Human Gene Mutation Database (HGMD)
DBF4B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBF4B Gene

Disorders for DBF4B Gene

No disorders were found for DBF4B Gene.

No data available for UniProtKB/Swiss-Prot for DBF4B Gene

Publications for DBF4B Gene

  1. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. (PMID: 15668232) Yoshizawa-Sugata N. … Masai H. (J. Biol. Chem. 2005) 2 3 4 23
  2. Drf1, a novel regulatory subunit for human Cdc7 kinase. (PMID: 12065429) Montagnoli A. … Santocanale C. (EMBO J. 2002) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Analysis of phosphatase and tensin homolog tumor suppressor interacting proteins by in vitro and in silico proteomics. (PMID: 15717329) Crockett D.K. … Lim M.S. (Proteomics 2005) 3
  5. Mapping DNA-protein interactions in large genomes by sequence tag analysis of genomic enrichment. (PMID: 15782160) Kim J. … Iyer V.R. (Nat. Methods 2005) 3

Products for DBF4B Gene

Sources for DBF4B Gene

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