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DBF4B Gene

protein-coding   GIFtS: 50
GCID: GC17P042785

DBF4 Zinc Finger B

(Previous name: DBF4 homolog B (S. cerevisiae))
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DBF4 Zinc Finger B1 2     Zinc Finger1
ASKL12 3 5     CHIFB2
DRF12 3 5     ZDBF1B2
Chiffon Homolog B2 3     Activator Of S-Phase Kinase-Like Protein 12
ASK-Like Protein 12 3     DBF4 Homolog B2
Dbf4-Related Factor 12 3     Protein DBF4 Homolog B2
Chiffon Homolog B (Drosophila)1     Zinc Finger, DBF-Type Containing 1B2
DBF-Type Containing 1B1     Activator Of S Phase Kinase-Like Protein 13
DBF4 Homolog B (S. Cerevisiae)1     

External Ids:    HGNC: 178831   Entrez Gene: 801742   Ensembl: ENSG000001616927   OMIM: 6116615   UniProtKB: Q8NFT63   

Export aliases for DBF4B gene to outside databases

Previous GC identifers: GC17P040142 GC17P038551


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DBF4B Gene:
This gene encodes a regulator of the cell division cycle 7 homolog (S. cerevisiae) protein, a serine-threonine
kinase which links cell cycle regulation to genome duplication. This protein localizes to the nucleus and, in
complex with the cell division cycle 7 homolog (S. cerevisiae) protein, may facilitate M phase progression.
Alternative splicing results in multiple transcript variants. (provided by RefSeq, Sep 2010)

GeneCards Summary for DBF4B Gene:
DBF4B (DBF4 zinc finger B) is a protein-coding gene. GO annotations related to this gene include nucleic acid binding. An important paralog of this gene is DBF4.

UniProtKB/Swiss-Prot: DBF4B_HUMAN, Q8NFT6
Function: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA
replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B
selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA
replication during cell cycle




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000017.10  NT_010783.16  NC_018928.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DBF4B gene promoter:
         ISGF-3   Pax-5   HTF   p300   Roaz   GATA-1   GATA-2   MRF-2   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DBF4B promoter sequence
   Search Chromatin IP Primers for DBF4B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DBF4B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 17q21.31|17q21   Ensembl cytogenetic band:  17q21.31   HGNC cytogenetic band: 17q21.31

DBF4B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DBF4B gene location

GeneLoc information about chromosome 17         GeneLoc Exon Structure

GeneLoc location for GC17P042785:  view genomic region     (about GC identifiers)

Start:
42,785,976 bp from pter      End:
42,829,637 bp from pter
Size:
43,662 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DBF4B_HUMAN, Q8NFT6 (See protein sequence)
Recommended Name: Protein DBF4 homolog B  
Size: 615 amino acids; 67243 Da
Subunit: Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4/DBF4A or DBF4B. Such
complexes are stable upon replication stress
Developmental stage: Increases as cells enter in S phase through G2/M phase. The protein has a short half-life (at
protein level)
Secondary accessions: D3DX56 Q8TEX0 Q96B19 Q9H912
Alternative splicing: 4 isoforms:  Q8NFT6-1   Q8NFT6-2   Q8NFT6-3   Q8NFT6-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DBF4B: NX_Q8NFT6

Explore proteomics data for DBF4B at MOPED

Post-translational modifications: 

  • Phosphorylated1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DBF4B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_079380.2  NP_663696.1  

    ENSEMBL proteins: 
     ENSP00000377178   ENSP00000323663   ENSP00000431158   ENSP00000381381  

    DBF4B Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZDBF: Zinc fingers, DBF-type

    2 InterPro protein domains:
     IPR006572 Znf_DBF
     IPR001357 BRCT_dom

    Graphical View of Domain Structure for InterPro Entry Q8NFT6

    ProtoNet protein and cluster: Q8NFT6

    UniProtKB/Swiss-Prot: DBF4B_HUMAN, Q8NFT6
    Similarity: Contains 1 BRCT domain
    Similarity: Contains 1 DBF4-type zinc finger


    Find genes that share domains with DBF4B           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DBF4B_HUMAN, Q8NFT6
    Function: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA
    replication and cell proliferation. Required for progression of S and M phases. The complex CDC7-DBF4B
    selectively phosphorylates MCM2 subunit at 'Ser-40' and then is involved in regulating the initiation of DNA
    replication during cell cycle

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008270zinc ion binding IEA--
    GO:0019901protein kinase binding IPI12065429
    GO:0030295protein kinase activator activity IDA12065429
         
    Find genes that share ontologies with DBF4B           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DBF4B

    miRNA
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    miRTarBase miRNAs that target DBF4B:
    hsa-mir-215-5p (MIRT024692), hsa-mir-192-5p (MIRT026609)

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    1 qRT-PCR Assays for microRNA that regulate DBF4B:
    hsa-miR-3065-3p
    SwitchGear 3'UTR luciferase reporter plasmidDBF4B 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DBF4B_HUMAN, Q8NFT6: Nucleus. Note=Predominantly found in soluble fraction but not in the chromatin-bound
    fraction
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0016235aggresome IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with DBF4B           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DBF4B About    
    See pathways by source

    SuperPathContained pathways About
    1Activation of the pre-replicative complex
    Cell cycle Start of DNA replication in early S phase0.53

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for DBF4B
        Cell cycle Start of DNA replication in early S phase



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DBF4B
    Interactions:

        Search GeneGlobe Interaction Network for DBF4B

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DBF4B (Q8NFT62, 3 ENSP000003236634) via UniProtKB, MINT, STRING, and/or I2D (see all 40)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    KRTAP4-12Q9BQ662, 3, ENSP000003775824MINT-67573 I2D: score=4 STRING: ENSP00000377582
    CDC7O003113, ENSP000002346264I2D: score=1 STRING: ENSP00000234626
    PTENP604843, ENSP000003610214I2D: score=1 STRING: ENSP00000361021
    MDFIQ997503, ENSP000002303214I2D: score=1 STRING: ENSP00000230321
    APCP250543I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007049cell cycle IEA--
    GO:0045860positive regulation of protein kinase activity IDA12065429

    Find genes that share ontologies with DBF4B           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DBF4B



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DBF4B gene (2 alternative transcripts): 
    NM_025104.3  NM_145663.2  

    Unigene Cluster for DBF4B:

    DBF4 homolog B (S. cerevisiae)
    Hs.369998  [show with all ESTs]
    Unigene Representative Sequence: NR_036623
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000393547(uc002ihd.2 uc010wjb.1 uc010wjc.2) ENST00000528766
    ENST00000528353 ENST00000315005(uc002ihf.3) ENST00000526924(uc002ihe.3)
    ENST00000526915 ENST00000525140(uc002ihg.3) ENST00000531699 ENST00000532789
    ENST00000527862 ENST00000398338
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate DBF4B:
    hsa-miR-3065-3p
    SwitchGear 3'UTR luciferase reporter plasmidDBF4B 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat DBF4B
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    Additional mRNA sequence: 

    AF448801.1 AK125771.1 AY358101.1 BC016158.1 BC033660.2 NR_036623.1 

    8 DOTS entries:

    DT.40283730  DT.423804  DT.40279570  DT.120983214  DT.100754986  DT.95071961  DT.120983207  DT.91729784 

    Selected AceView cDNA sequences (see all 79):

    AW139565 NM_025104 BC026999 AL043984 AU131166 AF448801 BU855745 AW290902 
    AK125771 NM_145663 BC016158 AA622743 BM476186 BU188746 AK023149 BM722891 
    AL042695 BE264947 BI667152 CK299943 BM672892 AI500030 AF465820 AI864428 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DBF4B (see all 9)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14a ·
    SP1:                                -     -                             -     -     -                                                                           
    SP2:                                -     -                             -     -     -                                                                           
    SP3:                                -     -                             -     -     -     -                                                                     
    SP4:                                                                    -     -     -                                   -                                       
    SP5:                                -     -                                                                                                                     

    ExUns: 14b · 14c ^ 15a · 15b ^ 16
    SP1:  -     -           -         
    SP2:  -     -                     
    SP3:                              
    SP4:                              
    SP5:                              


    ECgene alternative splicing isoforms for DBF4B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DBF4B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCATCTTCA
    DBF4B Expression
    About this image

    DBF4B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DBF4B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.369998

    UniProtKB/Swiss-Prot: DBF4B_HUMAN, Q8NFT6
    Tissue specificity: Widely expressed. Highly expressed in testis

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBF4B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DBF4B gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia DBF4B1 DBF4 homolog B (S. cerevisiae) 83.08(n)
    78.21(a)
      480497  XM_005624387.1  XP_005624444.1 
    lizard
    (Anolis carolinensis)
    Reptilia DBF4B6
    DBF4 homolog B (S. cerevisiae)
    35(a)
    1 ↔ 1
    6(63691136-63709687)
    African clawed frog
    (Xenopus laevis)
    Amphibia AY328889.12   -- 75.72(n)    AY328889.1 
    zebrafish
    (Danio rerio)
    Actinopterygii DBF4B6
    DBF4 homolog B (S. cerevisiae)
    13(a)
    1 ↔ 1
    12(14994714-15011351) ENSDARG00000086550


    ENSEMBL Gene Tree for DBF4B (if available)
    TreeFam Gene Tree for DBF4B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DBF4B gene
    DBF42  

    Find genes that share paralogs with DBF4B           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DBF4B (see all 950)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 17 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1392243071,2
    --42784000(+) TTGCTA/GATTGC 3 -- us2k10--------
    rs1153575101,2
    F--42784017(+) TAGGAT/ATCCCT 3 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1918892501,2
    --42784098(+) TAATTG/TATTTA 3 -- us2k10--------
    rs1433423731,2
    --42784114(+) CTGCCC/TGTTGT 3 -- us2k10--------
    rs1836327941,2
    C--42784118(+) CCGTTA/GTTAAT 3 -- us2k10--------
    rs1113776381,2
    C--42784441(+) GGCGCA/GGTGGC 3 -- us2k10--------
    rs1383345721,2
    --42784479(+) AGGCCA/GAGGCG 3 -- us2k10--------
    rs1882271651,2
    --42784832(+) ACTTTA/CGGCAA 3 -- us2k10--------
    rs1927748361,2
    --42785033(+) TGAGAA/GGGGAA 3 -- us2k10--------
    rs1835658421,2
    --42785079(+) GCAGCC/GAAACA 3 -- us2k10--------

    HapMap Linkage Disequilibrium report for DBF4B (42785976 - 42829637 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DBF4B:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2671681CNV Deletion23128226
    esv2663784CNV Deletion23128226
    nsv111783CNV Loss16902084
    nsv908286CNV Loss21882294
    nsv833456CNV Gain+Loss17160897

    Human Gene Mutation Database (HGMD): DBF4B
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DBF4B
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611661    OMIM disorders: --


    Find genes that share disorders with DBF4B           About GenesLikeMe


    Export disorders for DBF4B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DBF4B gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with DBF4B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A second human Dbf4/ASK-related protein, Drf1/ASKL1, is required for efficient progression of S and M phases. (PubMed id 15668232)1, 2, 3, 9 Yoshizawa-Sugata N....Masai H. (J. Biol. Chem. 2005)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Drf1, a novel regulatory subunit for human Cdc7 kinase. (PubMed id 12065429)1, 2 Montagnoli A.... Santocanale C. (EMBO J. 2002)
    4. The protein interaction landscape of the human CMGC kinase group. (PubMed id 23602568)1 Varjosalo M....Gstaiger M. (Cell Rep 2013)
    5. A Y2H-seq approach defines the human protein methyltransferase interactome. (PubMed id 23455924)1 Weimann M.... Stelzl U. (Nat. Methods 2013)
    6. An empirical framework for binary interactome mapping. (PubMed id 19060904)1 Venkatesan K....Vidal M. (Nat. Methods 2009)
    7. The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control. (PubMed id 19111665)1 Tsuji T....Jiang W. (Mol. Cell 2008)
    8. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    9. Cdc7 is an active kinase in human cancer cells undergoing replication stress. (PubMed id 17062569)2 Tenca P....Santocanale C. (J. Biol. Chem. 2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
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      Query String
    PubMed
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 80174 HGNC: 17883 AceView: DRF1 Ensembl:ENSG00000161692 euGenes: HUgn80174
    ECgene: DBF4B H-InvDB: DBF4B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DBF4B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DBF4B gene:
    Search GeneIP for patents involving DBF4B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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