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DBF4 Gene

protein-coding   GIFtS: 58
GCID: GC07P087505

DBF4 Zinc Finger

(Previous name: DBF4 homolog (S. cerevisiae))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DBF4 Zinc Finger1 2     Chiffon Homolog (Drosophila)1
Activator Of S Phase Kinase1 2 3     DBF-Type Containing 11
ASK2 3 5     DBF4 Homolog (S. Cerevisiae)1
DBF4 Zinc Finger A1 2     Zinc Finger1
Chiffon Homolog A2 3     CHIF2
DBF4A2 3     DBF4 Homolog2
ZDBF12 3     Protein DBF4 Homolog A2
DBF4-Type Zinc Finger-Containing Protein 12 3     Zinc Finger, DBF-Type Containing 12

External Ids:    HGNC: 173641   Entrez Gene: 109262   Ensembl: ENSG000000066347   OMIM: 6042815   UniProtKB: Q9UBU73   

Export aliases for DBF4 gene to outside databases

Previous GC identifers: GC07P087151 GC07P087343 GC07P082115


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DBF4 Gene:
DBF4 (DBF4 zinc finger) is a protein-coding gene. Diseases associated with DBF4 include anaplastic oligodendroglioma, and oligodendroglioma. GO annotations related to this gene include enzyme activator activity and nucleic acid binding. An important paralog of this gene is DBF4B.

UniProtKB/Swiss-Prot: DBF4A_HUMAN, Q9UBU7
Function: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA
replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively
phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA
replication during cell cycle

Gene Wiki entry for DBF4 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DBF4 gene promoter:
         AP-1   ATF-2   YY1   GATA-1   CREB   POU2F1   POU2F1b   POU2F1a   deltaCREB   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDBF4 promoter sequence
   Search Chromatin IP Primers for DBF4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DBF4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q21.3   Ensembl cytogenetic band:  7q21.12   HGNC cytogenetic band: 7q21.3

DBF4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DBF4 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P087505:  view genomic region     (about GC identifiers)

Start:
87,505,531 bp from pter      End:
87,538,856 bp from pter
Size:
33,326 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 86,836,862-86,870,174     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DBF4A_HUMAN, Q9UBU7 (See protein sequence)
Recommended Name: Protein DBF4 homolog A  
Size: 674 amino acids; 76858 Da
Subunit: Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such
complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2, ORC4 and ORC6
4 PDB 3D structures from and Proteopedia for DBF4:
4F99 (3D)        4F9A (3D)        4F9B (3D)        4F9C (3D)    
Secondary accessions: A4D1D8 A8K954 O75226 Q75MS6 Q75N01 Q9Y2M6
Alternative splicing: 2 isoforms:  Q9UBU7-1   Q9UBU7-2   

Explore the universe of human proteins at neXtProt for DBF4: NX_Q9UBU7

Explore proteomics data for DBF4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DBF4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006707.1  
    ENSEMBL proteins: 
     ENSP00000414083   ENSP00000265728   ENSP00000407116   ENSP00000389397  
    Reactome Protein details: Q9UBU7

    DBF4 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ZDBF: Zinc fingers, DBF-type

    2 InterPro protein domains:
     IPR006572 Znf_DBF
     IPR001357 BRCT_dom

    Graphical View of Domain Structure for InterPro Entry Q9UBU7

    ProtoNet protein and cluster: Q9UBU7

    UniProtKB/Swiss-Prot: DBF4A_HUMAN, Q9UBU7
    Similarity: Contains 2 BRCT domains
    Similarity: Contains 1 DBF4-type zinc finger


    DBF4 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DBF4A_HUMAN, Q9UBU7
    Function: Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA
    replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively
    phosphorylates MCM2 subunit at 'Ser-40' and 'Ser-53' and then is involved in regulating the initiation of DNA
    replication during cell cycle
    Induction: Induced in G1 phase at low level, increased during G1-S phase and remain high during S and G2-M phase

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0008047enzyme activator activity TAS10373557
    GO:0008270zinc ion binding IEA--
         
    DBF4 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for DBF4:
     Decreased viability  Increased S DNA content  S arrest  Synthetic lethal with imatinib 

         1 MGI phenotypic allele for Dbf4 (no phenotypes)

    DBF4 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DBF4
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DBF4
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    miRNA
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    miRTarBase miRNAs that target DBF4:
    hsa-mir-98-5p (MIRT027752)

    Block miRNA regulation of human, mouse, rat DBF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DBF4 (see all 13):
    hsa-miR-30c hsa-miR-3163 hsa-miR-498 hsa-miR-3607-3p hsa-miR-30d hsa-miR-340 hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidDBF4 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DBF4

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    GenScript: all cDNA clones in your preferred vector: DBF4 (NM_006716)
    Browse Sino Biological Human cDNA Clones
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBF4


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DBF4A_HUMAN, Q9UBU7: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus ----
    GO:0005654nucleoplasm TAS--

    DBF4 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DBF4 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Activation of the pre-replicative complex
    Activation of the pre-replicative complex0.66
    Cell cycle Start of DNA replication in early S phase0.53
    DNA Replication0.66
    2Cell cycle
    Cell cycle0.59
    Cell cycle0.59
    3CDK-mediated phosphorylation and removal of Cdc6
    DNA Replication0.92
    DNA Replication Pre-Initiation0.81
    M/G1 Transition0.81
    Cell Cycle Checkpoints0.58
    4Cell Cycle, Mitotic
    Cell Cycle, Mitotic0.90
    Cell Cycle0.90
    5G2/M Checkpoints
    G2/M Checkpoints0.84
    Activation of ATR in response to replication stress0.84

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for DBF4
        Cell cycle Start of DNA replication in early S phase

    2 BioSystems Pathways for DBF4
        Cell cycle
    DNA Replication

    2 Reactome Pathways for DBF4
        Activation of ATR in response to replication stress
    Activation of the pre-replicative complex


    1 Kegg Pathway  (Kegg details for DBF4):
        Cell cycle


    DBF4 for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DBF4
    Interactions:

        GeneGlobe Interaction Network for DBF4

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DBF4 (Q9UBU72, 3 ENSP000002657284) via UniProtKB, MINT, STRING, and/or I2D (see all 83)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CHAF1AQ131112, 3, ENSP000003012804MINT-2842119 I2D: score=2 STRING: ENSP00000301280
    CDC7O003113, ENSP000002346264I2D: score=5 STRING: ENSP00000234626
    ORC2Q134163, ENSP000002342964I2D: score=4 STRING: ENSP00000234296
    ORC1Q134153, ENSP000003606214I2D: score=2 STRING: ENSP00000360621
    ORC4O439293, ENSP000002641694I2D: score=2 STRING: ENSP00000264169
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000082G1/S transition of mitotic cell cycle TAS--
    GO:0000278mitotic cell cycle TAS--
    GO:0006260DNA replication TAS--
    GO:0043085positive regulation of catalytic activity TAS10373557

    DBF4 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DBF4 (DBF4A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DBF4 gene: 
    NM_006716.3  

    Unigene Cluster for DBF4:

    DBF4 homolog (S. cerevisiae)
    Hs.485380  [show with all ESTs]
    Unigene Representative Sequence: NM_006716
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000413643 ENST00000265728(uc003ujf.1 uc003ujh.1 uc003ujg.1 uc011khf.1)
    ENST00000495067 ENST00000431138 ENST00000486925 ENST00000430279 ENST00000498144
    ENST00000498726
    miRNA
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    Block miRNA regulation of human, mouse, rat DBF4 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DBF4 (see all 13):
    hsa-miR-30c hsa-miR-3163 hsa-miR-498 hsa-miR-3607-3p hsa-miR-30d hsa-miR-340 hsa-miR-30a hsa-miR-3613-3p
    SwitchGear 3'UTR luciferase reporter plasmidDBF4 3' UTR sequence
    Inhib. RNA
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    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DBF4
      QuantiTect SYBR Green Assays in human, mouse, rat DBF4
      QuantiFast Probe-based Assays in human, mouse, rat DBF4

    Additional mRNA sequence: 

    AB028069.1 AB028070.1 AF160249.1 AF160876.1 AK022969.1 AK292569.1 AK302010.1 AK303175.1 
    BC014909.1 BC022811.1 BC035632.1 BC036045.1 BC047693.1 

    10 DOTS entries:

    DT.455675  DT.100778051  DT.100697787  DT.121250434  DT.100817855  DT.91662416  DT.100817857  DT.100817860 
    DT.121250402  DT.121250409 

    Selected AceView cDNA sequences (see all 145):

    BM480263 BM847871 AA451820 BX348495 AA454151 AW582786 BC022811 BM854170 
    BC047693 AK022969 BU160067 CK141594 BM981447 NM_006716 BM474158 AI630093 
    BG724408 CB123764 AL548911 AA262811 BC014909 BC036045 BM819217 BM785927 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DBF4    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
    SP1:                                                                                    
    SP2:                                                                    -               
    SP3:        -                                                                           
    SP4:        -     -     -     -     -     -     -     -                                 


    ECgene alternative splicing isoforms for DBF4

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DBF4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATTCTGGTCT
    DBF4 Expression
    About this image


    DBF4 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Epithelial Cells
             Presumptive Podocytes Podocyte Layer
     
     Kidney (Urinary System)
             Presumptive Podocytes Podocyte Layer
     
     Testis (Reproductive System)
    DBF4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DBF4 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.485380

    UniProtKB/Swiss-Prot: DBF4A_HUMAN, Q9UBU7
    Tissue specificity: Highly expressed in testis and thymus. Expressed also in most cancer cells lines

        Custom PCR Arrays for DBF4
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    QuantiFast Probe-based Assays in human, mouse, rat DBF4
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBF4

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DBF4 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dbf41 , 5 DBF4 homolog (S. cerevisiae)1, 5 77.19(n)1
    68.13(a)1
      5 (3.43 cM)5
    272141  NM_001190717.11  NP_001177646.11 
     83969735 
    chicken
    (Gallus gallus)
    Aves DBF41 DBF4 homolog (S. cerevisiae) 60.9(n)
    49.25(a)
      420536  XM_004939269.1  XP_004939326.1 
    lizard
    (Anolis carolinensis)
    Reptilia DBF46
    DBF4 homolog (S. cerevisiae)
    42(a)
    1 ↔ 1
    6(19412017-19424287)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.208272 Xenopus laevis transcribed sequence with weak similarity more 79.87(n)    BQ884384.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dbf46
    DBF4 homolog (S. cerevisiae)
    26(a)
    1 ↔ 1
    16(45981958-45993438) ENSDARG00000074796


    ENSEMBL Gene Tree for DBF4 (if available)
    TreeFam Gene Tree for DBF4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DBF4 gene
    DBF4B2  

    DBF4 for paralogs           About GeneDecksing


    3 Pseudogenes.org Pseudogenes for DBF4
    PGOHUM00000238503 PGOHUM00000240257 PGOHUM00000240715


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DBF4 (see all 616)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs737069441,2
    C,F--87507756(+) GTAAAG/CTTCTT 1 -- int12Minor allele frequency- C:0.50WA CSA 4
    rs1809375251,2
    --87507791(+) GTGGAA/CCTGCT 1 -- int10--------
    rs1856054821,2
    --87507802(+) CATTGA/TCTGCT 1 -- int10--------
    rs765837941,2
    C,F--87507849(+) TTTCTT/GGATTA 1 -- int12Minor allele frequency- G:0.05WA EA 238
    rs1902637651,2
    --87507871(+) GAGCTA/GCATAA 1 -- int10--------
    rs561756421,2
    C--87507895(+) AGTGTA/GACAGT 1 -- int10--------
    rs743755471,2
    C--87507954(+) CCTGAA/GTGATA 1 -- int10--------
    rs749525451,2
    C--87507956(+) TGAGTA/GATACA 1 -- int10--------
    rs768907291,2
    C--87507958(+) AGTGAA/TACAGA 1 -- int10--------
    rs1143247991,2
    F--87508054(+) GATTAG/CATGAT 1 -- int11Minor allele frequency- C:0.01WA 118

    HapMap Linkage Disequilibrium report for DBF4 (87505531 - 87538856 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DBF4:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv888696CNV Loss21882294
    nsv525073CNV Gain19592680
    nsv464622CNV Gain19166990
    nsv888677CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 604281    OMIM disorders: --

    5 diseases for DBF4:    
    About MalaCards
    anaplastic oligodendroglioma    oligodendroglioma    ataxia telangiectasia    ataxia
    melanoma


    DBF4 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DBF4
    Human Genome Epidemiology (HuGE) Navigator: DBF4 (1 document)

    Export disorders for DBF4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DBF4 gene, integrated from 10 sources (see all 50):
    (articles sorted by number of sources associating them with DBF4)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. (PubMed id 10373557)1, 2, 3 Kumagai H.... Masai H. (Mol. Cell. Biol. 1999)
    2. Functional interaction between tumor suppressor menin and activator of S-phase kinase. (PubMed id 15374998)1, 2, 9 Schnepp R.W....Hua X. (Cancer Res. 2004)
    3. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. (PubMed id 10523313)1, 2, 9 Jiang W.... Hunter T. (EMBO J. 1999)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    7. Identification, characterization and chromosomal localization of the cognate human and murine DBF4 genes. (PubMed id 10517317)1, 3 Lepke M....Grummt F. (amp 1999)
    8. Human Dbf4/ASK promoter is activated through the Sp1 and MluI cell-cycle box (MCB) transcription elements. (PubMed id 12420215)1, 9 Wu X. and Lee H. (Oncogene 2002)
    9. The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control. (PubMed id 19111665)1, 9 Tsuji T....Jiang W. (Mol. Cell 2008)
    10. ATR-Chk1-APC/CCdh1-dependent stabilization of Cdc7-ASK (Dbf4) kinase is required for DNA lesion bypass under replication stress. (PubMed id 24240236)1 Yamada M....Bartek J. (amp 2013)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10926 HGNC: 17364 AceView: ASK Ensembl:ENSG00000006634 euGenes: HUgn10926
    ECgene: DBF4 Kegg: 10926 H-InvDB: DBF4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DBF4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DBF4 gene:
    Search GeneIP for patents involving DBF4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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