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Aliases for DBF4 Gene

Aliases for DBF4 Gene

  • DBF4 Zinc Finger 2 3 5
  • Activator Of S Phase Kinase 2 3 4
  • DBF4-Type Zinc Finger-Containing Protein 1 3 4
  • Zinc Finger, DBF-Type Containing 1 2 3
  • DBF4 Zinc Finger A 2 3
  • Chiffon Homolog A 3 4
  • DBF4A 3 4
  • ZDBF1 3 4
  • ASK 3 4
  • Chiffon Homolog (Drosophila) 2
  • DBF4 Homolog (S. Cerevisiae) 2
  • Protein DBF4 Homolog A 3
  • DBF4 Homolog 3
  • CHIF 3

External Ids for DBF4 Gene

Previous GeneCards Identifiers for DBF4 Gene

  • GC07P087151
  • GC07P087343
  • GC07P087505
  • GC07P082115

Summaries for DBF4 Gene

GeneCards Summary for DBF4 Gene

DBF4 (DBF4 Zinc Finger) is a Protein Coding gene. Among its related pathways are E2F mediated regulation of DNA replication and Cell Cycle Checkpoints. GO annotations related to this gene include nucleic acid binding and enzyme activator activity. An important paralog of this gene is DBF4B.

UniProtKB/Swiss-Prot for DBF4 Gene

  • Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at Ser-40 and Ser-53 and then is involved in regulating the initiation of DNA replication during cell cycle.

Gene Wiki entry for DBF4 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DBF4 Gene

Genomics for DBF4 Gene

Regulatory Elements for DBF4 Gene

Enhancers for DBF4 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G087925 0.9 ENCODE 12 +50.5 50475 2.2 HDGF TBP PKNOX1 NFIB FEZF1 YBX1 RAD21 EGR1 ZNF143 RELB DBF4 SLC25A40 ADAM22
GH07G087818 0.6 FANTOM5 0.2 -57.2 -57155 0.3 CTCF SMARCA4 MTA2 IKZF1 EP300 RAD21 SLC25A40 RUNDC3B ADAM22 GC07M087666 DBF4 PIR53232
GH07G087858 0.2 ENCODE 0.4 -17.6 -17596 0.2 DBF4 PIR53232 GC07M087666
GH07G087810 0.4 ENCODE 0.2 -65.9 -65921 0.6 CHD7 ATF2 SLC25A40 GC07M087666 PIR53232 DBF4
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DBF4 on UCSC Golden Path with GeneCards custom track

Promoters for DBF4 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000214800 -16 4401 HNRNPUL1 PKNOX1 FOXA2 CREB3L1 ZFP64 ARID4B SIN3A DMAP1 YY1 CBX5

Genomic Location for DBF4 Gene

Chromosome:
7
Start:
87,876,216 bp from pter
End:
87,909,541 bp from pter
Size:
33,326 bases
Orientation:
Plus strand

Genomic View for DBF4 Gene

Genes around DBF4 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DBF4 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DBF4 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DBF4 Gene

Proteins for DBF4 Gene

  • Protein details for DBF4 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UBU7-DBF4A_HUMAN
    Recommended name:
    Protein DBF4 homolog A
    Protein Accession:
    Q9UBU7
    Secondary Accessions:
    • A4D1D8
    • A8K954
    • O75226
    • Q75MS6
    • Q75N01
    • Q9Y2M6

    Protein attributes for DBF4 Gene

    Size:
    674 amino acids
    Molecular mass:
    76858 Da
    Quaternary structure:
    • Forms a complex with CDC7. Note that CDC7 forms distinct complex either with DBF4A or DBF4B. Such complexes are stable upon replication stress. Interacts with MEN1, MCM2, ORC2, ORC4 and ORC6.

    Three dimensional structures from OCA and Proteopedia for DBF4 Gene

    Alternative splice isoforms for DBF4 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DBF4 Gene

Post-translational modifications for DBF4 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DBF4 Gene

No data available for DME Specific Peptides for DBF4 Gene

Domains & Families for DBF4 Gene

Gene Families for DBF4 Gene

Protein Domains for DBF4 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DBF4: view

No data available for UniProtKB/Swiss-Prot for DBF4 Gene

Function for DBF4 Gene

Molecular function for DBF4 Gene

UniProtKB/Swiss-Prot Function:
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at Ser-40 and Ser-53 and then is involved in regulating the initiation of DNA replication during cell cycle.
UniProtKB/Swiss-Prot Induction:
Induced in G1 phase at low level, increased during G1-S phase and remain high during S and G2-M phase.

Gene Ontology (GO) - Molecular Function for DBF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0005515 protein binding IPI 16899510
GO:0008047 enzyme activator activity TAS 10373557
GO:0008270 zinc ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DBF4: view
genes like me logo Genes that share phenotypes with DBF4: view

Animal Models for DBF4 Gene

MGI Knock Outs for DBF4:
  • Dbf4 tm1b(KOMP)Wtsi

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DBF4
  • Applied Biological Materials Clones for DBF4

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DBF4 Gene

Localization for DBF4 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DBF4 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DBF4 gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for DBF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm TAS --
genes like me logo Genes that share ontologies with DBF4: view

Pathways & Interactions for DBF4 Gene

genes like me logo Genes that share pathways with DBF4: view

Pathways by source for DBF4 Gene

1 KEGG pathway for DBF4 Gene
1 GeneGo (Thomson Reuters) pathway for DBF4 Gene

SIGNOR curated interactions for DBF4 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for DBF4 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000082 G1/S transition of mitotic cell cycle TAS --
GO:0006260 DNA replication TAS --
GO:0007049 cell cycle IEA --
GO:0043085 positive regulation of catalytic activity IEA --
genes like me logo Genes that share ontologies with DBF4: view

Drugs & Compounds for DBF4 Gene

No Compound Related Data Available

Transcripts for DBF4 Gene

Unigene Clusters for DBF4 Gene

DBF4 homolog (S. cerevisiae):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for DBF4
  • Applied Biological Materials Clones for DBF4

Alternative Splicing Database (ASD) splice patterns (SP) for DBF4 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b
SP1:
SP2: -
SP3: -
SP4: - - - - - - - -

Relevant External Links for DBF4 Gene

GeneLoc Exon Structure for
DBF4
ECgene alternative splicing isoforms for
DBF4

Expression for DBF4 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DBF4 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DBF4 Gene

This gene is overexpressed in Testis (x8.8).

Protein differential expression in normal tissues from HIPED for DBF4 Gene

This gene is overexpressed in Testis (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DBF4 Gene



Protein tissue co-expression partners for DBF4 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DBF4 Gene:

DBF4

SOURCE GeneReport for Unigene cluster for DBF4 Gene:

Hs.485380

mRNA Expression by UniProt/SwissProt for DBF4 Gene:

Q9UBU7-DBF4A_HUMAN
Tissue specificity: Highly expressed in testis and thymus. Expressed also in most cancer cells lines.

Evidence on tissue expression from TISSUES for DBF4 Gene

  • Nervous system(4.8)
genes like me logo Genes that share expression patterns with DBF4: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DBF4 Gene

Orthologs for DBF4 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DBF4 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DBF4 34 35
  • 99.9 (n)
dog
(Canis familiaris)
Mammalia DBF4 34 35
  • 88.66 (n)
cow
(Bos Taurus)
Mammalia DBF4 34 35
  • 86.2 (n)
rat
(Rattus norvegicus)
Mammalia Dbf4 34
  • 78.03 (n)
mouse
(Mus musculus)
Mammalia Dbf4 34 16 35
  • 77.19 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 67 (a)
OneToMany
-- 35
  • 32 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia DBF4 35
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves DBF4 34 35
  • 60.9 (n)
lizard
(Anolis carolinensis)
Reptilia DBF4 35
  • 42 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.20827 34
zebrafish
(Danio rerio)
Actinopterygii dbf4 35
  • 26 (a)
OneToOne
Species where no ortholog for DBF4 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DBF4 Gene

ENSEMBL:
Gene Tree for DBF4 (if available)
TreeFam:
Gene Tree for DBF4 (if available)

Paralogs for DBF4 Gene

Paralogs for DBF4 Gene

Pseudogenes.org Pseudogenes for DBF4 Gene

genes like me logo Genes that share paralogs with DBF4: view

Variants for DBF4 Gene

Sequence variations from dbSNP and Humsavar for DBF4 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000043358 -- 87,901,652(+) ATAGG(A/C/G)TGAAA intron-variant
rs1000203144 -- 87,876,477(+) GCGGC(C/T)GCGTG upstream-variant-2KB, utr-variant-5-prime
rs1000331620 -- 87,896,912(+) AAAAT(A/C)TGTGC intron-variant
rs1000432458 -- 87,903,639(+) TAATA(A/G)AGGGA intron-variant
rs1000569876 -- 87,904,883(+) AAGAT(C/T)CTTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DBF4 Gene

Variant ID Type Subtype PubMed ID
nsv464622 CNV gain 19166990
nsv525073 CNV gain 19592680
nsv607725 CNV gain 21841781

Variation tolerance for DBF4 Gene

Residual Variation Intolerance Score: 76% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.47; 64.28% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DBF4 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DBF4

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DBF4 Gene

Disorders for DBF4 Gene

Relevant External Links for DBF4

Genetic Association Database (GAD)
DBF4
Human Genome Epidemiology (HuGE) Navigator
DBF4
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DBF4

No disorders were found for DBF4 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DBF4 Gene

Publications for DBF4 Gene

  1. Functional interaction between tumor suppressor menin and activator of S-phase kinase. (PMID: 15374998) Schnepp R.W. … Hua X. (Cancer Res. 2004) 3 4 22 64
  2. A novel growth- and cell cycle-regulated protein, ASK, activates human Cdc7-related kinase and is essential for G1/S transition in mammalian cells. (PMID: 10373557) Kumagai H. … Masai H. (Mol. Cell. Biol. 1999) 2 3 4 64
  3. Mammalian Cdc7-Dbf4 protein kinase complex is essential for initiation of DNA replication. (PMID: 10523313) Jiang W. … Hunter T. (EMBO J. 1999) 3 4 22 64
  4. The role of Dbf4/Drf1-dependent kinase Cdc7 in DNA-damage checkpoint control. (PMID: 19111665) Tsuji T. … Jiang W. (Mol. Cell 2008) 3 22 64
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64

Products for DBF4 Gene

  • Addgene plasmids for DBF4

Sources for DBF4 Gene

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