Aliases for DBF4 Gene
External Ids for DBF4 Gene
Previous GeneCards Identifiers for DBF4 Gene
GeneCards Summary for DBF4 Gene
DBF4 (DBF4 Zinc Finger) is a Protein Coding gene. Among its related pathways are E2F mediated regulation of DNA replication and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include nucleic acid binding and enzyme activator activity. An important paralog of this gene is DBF4B.
UniProtKB/Swiss-Prot for DBF4 Gene
Regulatory subunit for CDC7 which activates its kinase activity thereby playing a central role in DNA replication and cell proliferation. Required for progression of S phase. The complex CDC7-DBF4A selectively phosphorylates MCM2 subunit at Ser-40 and Ser-53 and then is involved in regulating the initiation of DNA replication during cell cycle.