DBC1 Gene
protein-coding GIFtS : 52
GCID: GC09 M121915
deleted in bladder cancer 1 (Previous name: deleted in bladder cancer chromosome region candidate 1... ) (Previous symbol: DBCCR1 )
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Aliasesfor DBC1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Deleted In Bladder Cancer 1 1 2 Deleted In Bladder Cancer Chromosome Region Candidate 11 2 DBCCR11 2 3 5 BA574M5.1 (Deleted In Bladder Cancer Chromosome Region Candidate 1 (IB3089A))2 FAM5A1 2 3 Deleted In Bladder Cancer Protein 12 BRINP11 2 Protein FAM5A3
Export aliases for DBC1 gene to outside databases Previous GC identifers: GC09U990016 GC09M117304 GC09M119008 GC09M120968 GC09M091546
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Summariesfor DBC1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for DBC1 : This gene is located within a chromosomal region that shows loss of heterozygosity in some bladder cancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, and it may undergo hypermethylation-based silencing in some bladder cancers. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: DBC1_HUMAN, O60477 Function : Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is notof the classical apoptotic type and regulates expression of components of the plasminogen pathway Gene Wiki entry for DBC1
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Genomic Viewsfor DBC1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_008470.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DBC1 gene promoter: MyoD MIF-1 Nkx2-5 NF-kappaB GATA-1 FOXI1 IRF-7A NF-kappaB1 Other transcription factors Search SABiosciences Chromatin IP Primers for DBC1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DBC1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9q32-q33 Ensembl cytogenetic band: 9q33.1 HGNC cytogenetic band: 9q32-q33 DBC1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09M121915: view genomic region
(about GC identifiers )
Start:
121,915,736 bp from pter
End:
122,131,745 bp from pter
Size:
216,010 bases
Orientation:
minus strand
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Proteinsfor DBC1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DBC1_HUMAN, O60477 (See
protein sequence )Recommended Name: Deleted in bladder cancer protein 1 precursor Size : 761 amino acids; 88760 Da
Subcellular location : Cytoplasm
Miscellaneous : DBC1 is silenced by methylation in 50% of bladder cancer cell lines
Secondary accessions : Q6IPV6 Q6P1A0 Q8WU22Alternative splicing : 3 isoforms : O60477-1 O60477-2 O60477-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DBC1: NX_O60477 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_O60477 DBC1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_055433.2 ENSEMBL proteins: ENSP00000363080 ENSP00000363075 ENSP00000265922 Human Recombinant Protein Products: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
DBC1 for ontologies About GeneDecksing DBC1 Antibody Products: Assay Products for DBC1:
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Protein
Domains / Familiesfor DBC1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DBC1 for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry O60477 ProtoNet protein and cluster: O60477
UniProtKB/Swiss-Prot: DBC1_HUMAN, O60477 Similarity : Belongs to the FAM5 familySimilarity : Contains 1 MACPF domain
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Functionfor DBC1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DBC1_HUMAN, O60477 Function : Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates cell death which is notof the classical apoptotic type and regulates expression of components of the plasminogen pathway
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DBC1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DBC1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DBC1 (NM_014618 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DBC1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DBC1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBC1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
IPI --
DBC1 for ontologies About GeneDecksing
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Pathways & Interactionsfor DBC1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DBC1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/26 Interacting proteins for DBC1 (O60477 1 , 3 ENSP00000265922 4 ) via UniProtKB, MINT, STRING , and/or I2D (see all 26 )About this table Gene Ontology (GO): 3 biological process terms (GO ID links to tree view) : About this table
DBC1 for ontologies About GeneDecksing
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Drugs & Compoundsfor DBC1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for DBC1 Search CenterWatch for drugs/clinical trials and news about DBC1
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Transcriptsfor DBC1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DBC1 gene: NM_014618.2 Unigene Cluster for DBC1:
Deleted in bladder cancer 1 Hs.532316 [show with all ESTs ] Unigene Representative Sequence: NM_014618 4 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000482797 ENST00000373969 ENST00000373964 (uc004bkd.2 ) ENST00000265922 (uc004bkc.2 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DBC1 (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DBC1OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DBC1 (NM_014618 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DBC1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DBC1
Additional cDNA sequence: AF027734.1 AK293501.1 AK293649.1 BC021560.1 BC065196.1 BC071702.1
8 DOTS entries : DT.113756 DT.100744735
DT.91899659 DT.92418485 DT.92418486 DT.95373446 DT.95373447 DT.99974558 24/58 AceView cDNA sequences (see all 58 ):
BM726737 F08986 Z41452 T16063 BU626191 BC071702 BM929506 BI488483 AI874202 BC021560 BF309931 NM_014618 BC065196 BF348205 R42933 BG419841 AW955370 BI489454 BX096489 T15661 AA326334 CB047003 BM681521 AA599898 GeneLoc Exon Structure
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Expression for DBC1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DBC1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: --
About this image DBC1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See DBC1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DBC1 SOURCE GeneReport for Unigene cluster: Hs.532316 UniProtKB/Swiss-Prot: DBC1_HUMAN, O60477 Tissue specificity : Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle, kidney, thymus,prostate, testis and small intestine SABiosciences Custom PCR Arrays for DBC1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DBC1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat DBC1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DBC1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DBC1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBC1
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Orthologsfor DBC1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for DBC1 gene from 5/11 species (see all 11 ) About this table
ENSEMBL Gene Tree for DBC1 (if available)TreeFam Gene Tree for DBC1 (if available)
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Paralogsfor DBC1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DBC1 gene FAM5B 2 FAM5C 2 2 SIMAP similar genes for DBC1 using alignment to 1 protein entry: DBC1_HUMAN :FAM5B FAM5C
DBC1 for paralogs About GeneDecksing
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Genomic Variantsfor DBC1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 9 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DBC1 (121915736 - 122131745 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for DBC1 1 Indel : 60766
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DBC1
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Disorders
/ Diseasesfor DBC1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DBC1 for disorders About GeneDecksing
OMIM gene information: 602865
OMIM disorders : --13 diseases for DBC1 : About MalaCards non-invasive bladder papillary urothelial neoplasm urinary bladder cancer oral squamous cell carcinoma squamous cell carcinoma transitional cell carcinoma multiple sclerosis parkinson's disease carcinoma breast carcinoma astrocytoma lung cancer breast cancer prostatitis 1 disease from the University of Copenhagen DISEASES database for DBC1 :non-invasive bladder papillary urothelial neoplasm 5 Novoseek disease relationships for DBC1 gene About this table
Human Genome Epidemiology (HuGE) Navigator: DBC1 (6 documents) Export disorders for DBC1 gene to outside databases
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Publicationsfor DBC1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DBC1 gene, integrated from 9 sources (see all 43 ): (articles sorted by number of sources associating them with DBC1) Utopia : connect your pdf to the dynamic world of online information
Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. (PubMed id 11420708) 1 , 2 , 9 Nishiyama H.... Knowles M.A. (2001) DBCCR1 mediates death in cultured bladder tumor cells. (PubMed id 14712213) 1 , 2 , 9 Wright K.O.... Reeder J.E. (2004) Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. (PubMed id 9545632) 1 , 2 , 9 Habuchi T.... Knowles M.A. (1998) A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33. (PubMed id 10444335) 1 , 3, 9 Nishiyama H....Knowles M.A. (1999) DBC1 re-expression alters the expression of multiple components of the plasminogen pathway. (PubMed id 16369496) 1 , 2 Louhelainen J.P....Knowles M.A. (2006) DNA sequence and analysis of human chromosome 9. (PubMed id 15164053) 1 , 2 Humphray S.J.... Dunham I. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC. (PubMed id 9175739) 1 , 3 Habuchi T....Knowles M.A. (1997) Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. (PubMed id 15746151) 1 , 9 Izumi H....Imoto I. (2005) Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. (PubMed id 12442002) 1 , 9 Wright K.O....Reeder J.E. (2002)
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External Searches for DBC1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DBC1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DBC1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DBC1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for DBC1 gene: Search GeneIP for patents involving DBC1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DBC1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
OriGene Antibodies for DBC1 OriGene shRNA RFP for DBC1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DBC1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DBC1 Browse OriGene Protein Over-expression Lysates Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DBC1 OriGene 3'-UTR Clone for DBC1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DBC1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DBC1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DBC1 OriGene Custom Protein Services for DBC1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DBC1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DBC1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human , mouse , rat DBC1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DBC1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DBC1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DBC1
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DBC1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DBC1
ThermoFisher Antibodies for DBC1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DBC1
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Aliases for DBC1
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Disorders / Diseases for DBC1
Domains / Families for DBC1
Drugs / Compounds for DBC1
Expression for DBC1
Function for DBC1
Genomic Views for DBC1
Intellectual Property for DBC1
Orthologs for DBC1
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Pathways / Interactions for DBC1
Products for DBC1
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Summaries for DBC1
Transcripts for DBC1
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