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Aliases & Descriptions for DBC1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DBCCR1 2 , 3 FAM5A 1 , 2 , 3 KIAA1967 5 OTTHUMP00000022751 2
Descriptions Protein FAM5A 3 bA574M5.1 (deleted in bladder cancer chromosome region candidate 1 (IB3089A)) 2 deleted in bladder cancer 1 2 deleted in bladder cancer chromosome region candidate 1 1 , 2
Search outside databases for aliases for DBC1 genePrevious GC identifers: GC09U990016 GC09M117304 GC09M119008
Summaries for DBC1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for DBC1 : This gene is located within a chromosomal region that shows loss of heterozygosity in some bladdercancers. It contains a 5' CpG island that may be a frequent target of hypermethylation, andit may undergo hypermethylation-based silencing in some bladder cancers. [provided by RefSeq] UniProtKB/Swiss-Prot: DBC1_HUMAN, O60477 Function : Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates celldeath which is not of the classical apoptotic type and regulates expression of components of theplasminogen pathway
Gene Wiki entry for DBC1
Genomic Location for DBC1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the DBC1 gene Entrez Gene cytogenetic band: 9q32-q33 Ensembl cytogenetic band: 9q33.1 HGNC cytogenetic band: 9q32-q33 DBC1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09M120968:
(about GC identifiers )
Start:
120,968,728 bp from pter
End:
121,171,566 bp from pter
Size:
202,839 bases
Orientation:
minus strand
RefSeq DNA sequence: NC_000009.10 NT_008470.18 Proteins for DBC1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: DBC1_HUMAN, O60477 (See
protein sequence )Recommended Name: Deleted in bladder cancer protein 1 precursor Size : 761 amino acids; 88760 Da
Subcellular location : Cytoplasm
Miscellaneous : DBC1 is silenced by methylation in 50% of bladder cancer cell lines
Secondary accessions : Q6IPV6 Q6P1A0 Q8WU22Alternative splicing : 3 isoforms : O60477-1 O60477-2 O60477-3
REFSEQ proteins: NP_055433.2 ENSEMBL proteins: ENSP00000363080 ENSP00000363075 ENSP00000265922 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
About this table Antibodies for DBC1: Assays for DBC1:
Protein
Domains/ Families for DBC1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry O60477 ProtoNet protein and cluster: O60477
UniProtKB/Swiss-Prot: DBC1_HUMAN, O60477 Similarity : Belongs to the FAM5 familySimilarity : Contains 1 MACPF domain
Gene Function for DBC1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014618 Applied Biosystems Silencer ® siRNAs for DBC1 Sigma-Aldrich siRNA for DBC1 Sigma-Aldrich shRNA for DBC1 Explore Sigma-Aldrich super-pooled esiRNAs               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014618                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014618                                  untagged cDNA clone in CMV expression vector: NM_014618  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014618 UniProtKB/Swiss-Prot: DBC1_HUMAN, O60477 Function : Inhibits cell proliferation by negative regulation of the G1/S transition. Mediates celldeath which is not of the classical apoptotic type and regulates expression of components of theplasminogen pathway
1 Gene Ontology (GO) molecular function term (links to tree view) :
About this table
Pathways & Interactions for DBC1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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3 Interacting proteins for DBC1 (ENSP00000363080 3 ) via UniProtKB, MINT, and/or STRING About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
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Drugs & Compounds for DBC1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for DBC1
Transcripts for DBC1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
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shRNA from
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              OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014618 Sigma-Aldrich siRNA for DBC1 Sigma-Aldrich shRNA for DBC1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_014618
REFSEQ mRNAs for DBC1 gene: NM_014618.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014618
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014618                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014618                                  untagged cDNA clone in CMV expression vector: NM_014618  
Additional cDNA sequence: AF027734.1 AK293501.1 AK293649.1 BC021560.1 BC065196.1 BC071702.1
8 DOTS entries : DT.113756 DT.100744735 DT.91899659 DT.92418485 DT.92418486 DT.95373446 DT.95373447 DT.99974558
24/58 AceView cDNA sequences (see all 58
):BU626191 BM929506 BI488483 Z41452 F08986 BC071702 T16063 AI874202 BM726737 AW955370 CD625836 BC021560 AI753300 NM_014618 BG828045 R42933 BM681521 AA599898 AA948693 BF348205 BG419841 AF027734 CB047003 AA326334
highest scoring ESTs for DBC1 :AF027734 BC021560 BC065196 BC071702 BG419841 BI755901 BI917293 BQ889616 BX441404 CD652209
Unigene Cluster for DBC1: Deleted in bladder cancer 1 Hs.532316 [show with all ESTs ] Unigene Representative Sequence: NM_014618 GeneLoc Exon Structure 3 Ensembl transcripts including schematic representations : ENST00000373969
ENST00000373964
ENST00000265922
Expression for DBC1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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DBC1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for DBC1 1 / 2 / 3
4 probe-sets matching DBC1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.532316 Expression variation in blood from EXPOLDB for DBC1
UniProtKB/Swiss-Prot: DBC1_HUMAN, O60477 Tissue specificity : Highly expressed in brain. Weakly expressed in heart, lung, skeletal muscle,kidney, thymus, prostate, testis and small intestine
Orthologs for DBC1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for DBC1 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for DBC1 ENSEMBL Gene Tree for DBC1 Paralogs for DBC1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for DBC1 gene FAM5B 2 FAM5C 2
SNPs/Variants for DBC1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for DBC1 (up to first 250kb)
Disorders & Mutations for DBC1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607359 5 Novoseek disease relationships for DBC1 gene
About this table Human Genome Epidemiology Navigator: DBC1 (1 document)
Medical News for DBC1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for DBC1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/29 PubMed articles for DBC1 gene (see all 29
): Negative regulation of G(1)/S transition by the candidate bladder tumour suppressor gene DBCCR1. (PubMed id 11420708) 1, 3, 4 Nishiyama H.... Knowles M.A. (2001) DBCCR1 mediates death in cultured bladder tumor cells. (PubMed id 14712213) 1, 3, 4 Wright K.O.... Reeder J.E. (2004) Structure and methylation-based silencing of a gene (DBCCR1) within a candidate bladder cancer tumor suppressor region at 9q32-q33. (PubMed id 9545632) 1, 3, 4 Habuchi T.... Knowles M.A. (1998) A sequence-ready 840-kb PAC contig spanning the candidate tumor suppressor locus DBC1 on human chromosome 9q32-q33. (PubMed id 10444335) 1, 2, 3 Nishiyama H....Knowles M.A. (1999) DBC1 re-expression alters the expression of multiple components of the plasminogen pathway. (PubMed id 16369496) 3, 4 Louhelainen J.P....Knowles M.A. (2006) DNA sequence and analysis of human chromosome 9. (PubMed id 15164053) 3, 4 Humphray S.J.... Dunham I. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) A novel candidate tumour suppressor locus at 9q32-33 in bladder cancer: localization of the candidate region within a single 840 kb YAC. (PubMed id 9175739) 2, 3 Habuchi T....Knowles M.A. (1997) Frequent silencing of DBC1 is by genetic or epigenetic mechanisms in non-small cell lung cancers. (PubMed id 15746151) 1, 3 Izumi H....Imoto I. (2005) Increased expression of the acid sphingomyelinase-like protein ASML3a in bladder tumors. (PubMed id 12442002) 1, 3 Wright K.O....Reeder J.E. (2002)
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Genome Databases showing DBC1
(According to
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AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
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Other Databases showing DBC1
(According to HUGE )
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Specialized Databases showing DBC1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for DBC1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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