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DAZL Gene

protein-coding   GIFtS: 61
GCID: GC03M016603

Deleted In Azoospermia-Like


(Previous symbol: DAZLA)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deleted In Azoospermia-Like1 2     SPGY-like-autosomal2 3
DAZLA1 2 3     DAZ Homolog2 3
DAZH2 3 5     DAZ-Like Autosomal2 3
SPGYLA2 3 5     Germline Specific RNA Binding Protein2
Deleted In Azoospermia-Like 12 3     Spermatogenesis Gene On The Y-Like Autosomal2
DAZL12 3     

External Ids:    HGNC: 26851   Entrez Gene: 16182   Ensembl: ENSG000000923457   OMIM: 6014865   UniProtKB: Q929043   

Export aliases for DAZL gene to outside databases

Previous GC identifer: GC03M016557


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAZL Gene:
The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal
and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and
cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is
localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in
spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave
rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic
failure and infertility in males. Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jun 2010)

GeneCards Summary for DAZL Gene:
DAZL (deleted in azoospermia-like) is a protein-coding gene. Diseases associated with DAZL include spermatogenic failure, and azoospermia. GO annotations related to this gene include RNA binding and translation activator activity. An important paralog of this gene is DAZ1.

UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
Function: RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central
role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and
thereby regulating the translation of key transcripts (By similarity)

Gene Wiki entry for DAZL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000003.12  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAZL gene promoter:
         Max1   Pbx1a   Pax-6   MEF-2A   AREB6   FOXJ2 (long isoform)   aMEF-2   FOXJ2   RSRFC4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAZL promoter sequence
   Search Chromatin IP Primers for DAZL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAZL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24

DAZL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAZL gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M016603:  view genomic region     (about GC identifiers)

Start:
16,628,299 bp from pter      End:
16,711,813 bp from pter
Size:
83,515 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904 (See protein sequence)
Recommended Name: Deleted in azoospermia-like  
Size: 295 amino acids; 33178 Da
Subunit: Homodimer and heterodimer. Multiple DAZL RRMs can bind to a single RNA containing multiple GUU triplets
(By similarity). Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2
Secondary accessions: O15396 Q5HYB4 Q92909
Alternative splicing: 2 isoforms:  Q92904-1   Q92904-2   

Explore the universe of human proteins at neXtProt for DAZL: NX_Q92904

Explore proteomics data for DAZL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DAZL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177740.1  NP_001342.2  

    ENSEMBL proteins: 
     ENSP00000250863   ENSP00000382373   ENSP00000398109  

    DAZL Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for DAZL


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q92904

    ProtoNet protein and cluster: Q92904

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
    Domain: The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2
    Similarity: Belongs to the RRM DAZ family
    Similarity: Contains 1 DAZ-like domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    DAZL for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAZL_HUMAN, Q92904
    Function: RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central
    role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and
    thereby regulating the translation of key transcripts (By similarity)

         Genatlas biochemistry entry for DAZL:
    deleted in azoospermia,autosomal-like,homolog of the mouse Dazla gene and the Drosophila boule (SPGY like
    autosomal),expressed only in male gonad

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS8968755
    GO:0003730mRNA 3'-UTR binding IEA--
    GO:0005515protein binding IPI16001084
         
    DAZL for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DAZL:
     Increased G2M DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dazl):
     endocrine/exocrine gland  reproductive system 

    DAZL for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dazltm1Hjc for DAZL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DAZL
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DAZL

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DAZL
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAZL

    miRNA
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    miRTarBase miRNAs that target DAZL:
    hsa-mir-335-5p (MIRT016720)

    Block miRNA regulation of human, mouse, rat DAZL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAZL (see all 22):
    hsa-miR-3938 hsa-miR-607 hsa-miR-3664-5p hsa-miR-4328 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidDAZL 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DAZL
    Predesigned siRNA for gene silencing in human, mouse, rat DAZL

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): DAZL (NM_001351)
    Sino Biological Human cDNA Clone for DAZL
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAZL
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAZL

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAZL


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DAZL_HUMAN, Q92904: Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (By
    similarity). Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization
    from then onward (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005844polysome IEA--

    DAZL for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAZL About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control
    2Ovarian Infertility Genes
    Ovarian Infertility Genes

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DAZL
        Translational Control

    1 BioSystems Pathway for DAZL
        Ovarian Infertility Genes




    DAZL for pathways           About GeneDecksing

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DAZL
    Interactions:

        GeneGlobe Interaction Network for DAZL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for DAZL (Q929043 ENSP000003823734) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAZ1Q9NQZ33, ENSP000003845734I2D: score=3 STRING: ENSP00000384573
    DAZAP1Q96EP53, ENSP000002330784I2D: score=2 STRING: ENSP00000233078
    DCTN1Q142033, ENSP000003547914I2D: score=1 STRING: ENSP00000354791
    DCTN2Q135613, ENSP000004089104I2D: score=1 STRING: ENSP00000408910
    DYNC1I1O145763, ENSP000003201304I2D: score=1 STRING: ENSP00000320130
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007281germ cell development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0045836positive regulation of meiosis IEA--
    GO:0045948positive regulation of translational initiation IDA16001084

    DAZL for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAZL

    2 Novoseek inferred chemical compound relationships for DAZL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vas-a 55.3 14 18088417 (8), 16228988 (2), 19573297 (1), 19602557 (1) (see all 5)
    adenylate 0.705 4 10819768 (1)



    DAZL for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DAZL gene (2 alternative transcripts): 
    NM_001190811.1  NM_001351.3  

    Unigene Cluster for DAZL:

    Deleted in azoospermia-like
    Hs.131179  [show with all ESTs]
    Unigene Representative Sequence: NM_001190811
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250863(uc003cba.3) ENST00000399444(uc003cbb.3) ENST00000454457

    miRNA
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    Block miRNA regulation of human, mouse, rat DAZL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAZL (see all 22):
    hsa-miR-3938 hsa-miR-607 hsa-miR-3664-5p hsa-miR-4328 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidDAZL 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat DAZL
    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAZL
    Primer
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      QuantiTect SYBR Green Assays in human, mouse, rat DAZL
      QuantiFast Probe-based Assays in human, mouse, rat DAZL

    Additional mRNA sequence: 

    AK303026.1 AK310341.1 BC027595.2 BX648638.1 U65918.1 U66078.1 U66726.2 

    2 DOTS entries:

    DT.310516  DT.97804595 

    Selected AceView cDNA sequences (see all 52):

    NM_001351 AL705991 BX648638 BI464024 BI461267 BG723910 BG718804 BG210841 
    BX088864 BG771817 BG207704 U66078 CD300236 BF980336 BI464057 BI829533 
    BU569412 BI459106 BI460958 AL044707 BU853969 AA774538 CD557344 U66726 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAZL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAAATA
    DAZL Expression
    About this image


    DAZL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Gonad (Reproductive System)    fully expand to see all 9 entries
             Primordial Germ Cells Primitive Gonad
             Primordial germ-like cells
     
     Germ Cells (Reproductive System)    fully expand to see all 5 entries
             Primordial germ-like cells
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             XX Germ Cells Ovigerous Cord
             Ovarian tissue-dissociated cells (human)
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             ES-J1
    DAZL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAZL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131179

    UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
    Tissue specificity: Testis specific

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAZL

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DAZL gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dazl5 deleted in azoospermia-like   --   17 (25.86 cM) 50279394 
    chicken
    (Gallus gallus)
    Aves DAZL6
    Gallus gallus deleted in azoospermia-like (DAZL), ...
    65(a)
    1 → many
    2(34939869-35003900)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    65(a)
    1 → many
    6(34873464-34894381)
    African clawed frog
    (Xenopus laevis)
    Amphibia dazl2 DAZ-like protein 77.98(n)    AF017778.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dazl2 daz-like gene 73.65(n)   58039  AB018191.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bol6
    boule
    25(a)
    1 → many
    3L(9091208-9123452)
    worm
    (Caenorhabditis elegans)
    Secernentea daz-16
    Protein DAZ-1 (daz-1) mRNA, complete cds
    15(a)
    1 → many
    II(5456305-5458616) WBGene00000935


    ENSEMBL Gene Tree for DAZL (if available)
    TreeFam Gene Tree for DAZL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAZL gene
    DAZ12  DAZ32  DAZ42  DAZ22  BOLL2  
    8 SIMAP similar genes for DAZL using alignment to 3 protein entries:     DAZL_HUMAN (see all proteins):
    DAZ2    DAZ3    DAZ4    DAZ1    BOLL    RBMY1A1
    RBFOX2    HNRNPA2B1

    DAZL for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for DAZL
    PGOHUM00000233822 PGOHUM00000233854 PGOHUM00000234035 PGOHUM00000234068


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAZL (see all 565)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18085181,2
    C,F,A,H--16563813(+) ACTAAA/CTGATG 2 -- int1102Minor allele frequency- C:0.31NS NA EA PA EU CA WA 6430
    rs610935751,2
    --16563879(+) ATTGGG/TAGTAC 2 -- int10--------
    rs1482689151,2
    --16563928(+) TTTTTG/TATTGC 2 -- int10--------
    rs751483541,2
    F--16563938(+) CATCCA/GTAAGA 2 -- int11Minor allele frequency- G:0.02WA 118
    rs170424401,2
    C,F--16563984(+) GCAACC/TGCAAT 2 -- int13Minor allele frequency- T:0.01NA 138
    rs1140936681,2
    F--16564005(+) AAAAGG/TTCTAG 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1911524701,2
    --16564017(+) GATTAA/GGCCCA 2 -- int10--------
    rs105104531,2
    C,F,H--16564027(+) AAAGCG/ATACAG 2 -- int1104Minor allele frequency- A:0.09NS NA EA PA EU CA WA CSA 6304
    rs1503824991,2
    C--16564095(+) AGTCAG/TATGTG 2 -- int10--------
    rs23473121,2
    C,A,H--16564318(+) AAAAAG/CTTTAT 2 -- ut3111Minor allele frequency- C:0.25EA WA NA CSA 1843
    rs1179860671,2
    C,F--16564396(+) TTTCCA/GTTTTG 2 -- ut311Minor allele frequency- G:0.01EA 120
    rs1379881331,2
    --16564543(+) ATTTAC/TAGTAA 2 -- ut310--------
    rs1425740831,2
    --16564916(+) CTACCA/GTTCCA 2 -- ut310--------
    rs731425091,2
    C--16564970(+) TCTTTA/GTATCA 2 -- ut312Minor allele frequency- G:0.04WA 120
    rs1823588251,2
    --16565145(+) TAAGAC/TATACT 2 -- ut310--------
    rs1459557611,2
    C--16565167(+) TTTTGG/TGGTTT 2 -- ut310--------
    rs1849987201,2
    --16565196(+) CTACTC/TTGACT 2 -- ut310--------
    rs789725931,2
    C,F--16565279(+) TCAATG/ATTTTT 2 -- ut313Minor allele frequency- A:0.22WA NA EA 358
    rs20597431,2
    C,F,O,A,H--16565326(+) CTAAGT/AGACAT 2 -- ut31 ese392Minor allele frequency- A:0.27NS MN EA PA EU CA WA NA CSA 4430
    rs1831185241,2
    --16565374(+) ACAATC/TTGACA 2 -- ut310--------
    rs1398923721,2
    C--16565607(+) TGATTA/GGACTG 2 -- ut310--------
    rs105104541,2
    C,F,H--16565610(+) TTGGAC/TTGTTC 2 -- ut3197Minor allele frequency- T:0.30NS EA NA PA EU CA WA 6032
    rs774289561,2
    C,F--16565612(+) GGACTG/ATTCGC 2 -- ut311Minor allele frequency- A:0.03WA 118
    rs1492432251,2
    C--16565615(+) CTGTTC/TGCTTT 2 -- ut310--------
    rs1873836151,2
    --16565658(+) TTCAAC/TAAAGC 2 -- ut310--------
    rs1930279861,2
    --16565709(+) AAAAAC/TTTTGC 2 -- ut310--------
    rs1833854481,2
    C--16565791(+) ACTTGC/TTGGAG 2 -- ut310--------
    rs1144317611,2
    C,F--16565793(+) TTGTTG/AGAGAA 2 -- ut311Minor allele frequency- A:0.01NA 120
    rs1444591801,2
    --16565808(+) AATGTC/TTGTAT 2 -- ut310--------
    rs170424431,2
    C,F,H--16565823(+) ACCAAC/GAAAAT 2 -- ut318Minor allele frequency- G:0.03NA NS EA WA 662
    rs1884476971,2
    --16565937(+) TTAGTC/TTCTTT 2 -- ut310--------
    rs1487905871,2
    C,F--16566248(+) AGTCCT/CTTTAC 2 -- int11Minor allele frequency- C:0.02EU 1311
    rs1424414471,2
    --16566295(+) AAGTTG/TTCAAA 2 -- int10--------
    rs1479605371,2
    --16566384(+) ACACTA/GGGATA 2 -- int10--------
    rs21951531,2
    C,F,H--16566418(+) TTTATT/AAAACA 2 -- int17Minor allele frequency- A:0.24NS EA WA NA 776
    rs2012709981,2
    C--16566434(+) GTTAA-/AAAAG 
            
    AAATC
    2 -- int10--------
    rs123741511,2
    C,F,H--16566509(+) TTTATG/ATACTT 2 -- int115Minor allele frequency- A:0.09NS EA NA 1740
    rs1400408081,2
    C--16566582(+) ATACTC/GTTTTC 2 -- int10--------
    rs1151403901,2
    C,F--16566585(+) CTGTTT/CTCACT 2 -- int11Minor allele frequency- C:0.03WA 118
    rs1926316341,2
    --16566710(+) GTGAAA/GATGTA 2 -- int10--------
    rs2019146981,2
    --16566737(+) AAGAG-/AAAAAA 2 -- int10--------
    rs9300391,2
    C,A,H--16566742(+) AAAAAT/ATTTAA 2 -- int1 trp310Minor allele frequency- A:0.20WA NA CSA EA 370
    rs37738251,2
    C,F,H--16566745(+) AAATTT/AAAATA 2 -- int12Minor allele frequency- A:0.50NA 4
    rs1839135701,2
    --16566787(+) CTACAC/GATGTG 2 -- int10--------
    rs1866522371,2
    --16566839(+) CTAAGC/TAAATG 2 -- int10--------
    rs1925778851,2
    --16566865(+) GCATTC/TTATTT 2 -- int10--------
    rs1847424221,2
    --16567027(+) GGTCAA/CGCAGG 2 -- int10--------
    rs1455572011,2
    --16567062(+) GAATCA/TAGACA 2 -- int10--------
    rs1900362381,2
    --16567063(+) AATCAA/GGACAG 2 -- int10--------
    rs1136611981,2
    C,F--16567227(+) AAACTC/TTGGGA 2 -- int12Minor allele frequency- T:0.50CSA 4
    rs1165218441,2
    F--16567292(+) CTTCTG/CGGCTG 2 -- int11Minor allele frequency- C:0.03WA 118
    rs1476926141,2
    --16567313(+) CTCACA/GCCTGT 2 -- int10--------
    rs1410094331,2
    --16567481(+) TTTGGA/GAGGCT 2 -- int10--------
    rs1821601391,2
    --16567509(+) TGCGTC/TAGGAG 2 -- int10--------
    rs731425121,2
    C,F--16567532(+) GTAAGC/TTGTGA 2 -- int12Minor allele frequency- T:0.07WA 120
    rs773207481,2
    C,F--16567551(+) CTGCAA/CTCCAG 2 -- int13Minor allele frequency- C:0.21WA NA EA 358
    rs2005381931,2
    C--16567616(+) CTTCTA/GCTTTG 2 -- int10--------
    rs1851651461,2
    C--16567689(+) TGATAC/TACAAT 2 -- int10--------
    rs1497661981,2
    C--16567712(+) TTTTCC/TAAATT 2 -- int10--------
    rs1899632401,2
    --16567723(+) ATACTA/GTCTAT 2 -- int10--------
    rs1811447011,2
    --16567724(+) TACTAC/TCTATG 2 -- int10--------
    rs1409233841,2
    C--16567776(+) GTTTA-/CTCC  
            
    CTGTT
    2 -- int10--------
    rs764194141,2
    C,F--16567801(+) AAGAAC/TTTAAT 2 -- int13Minor allele frequency- T:0.22WA NA EA 358
    rs785350351,2
    C--16567817(+) TATACA/GGCTCT 2 -- int10--------
    rs1489332931,2
    --16567847(+) GAGATC/GCATAA 2 -- int10--------
    rs1153056571,2
    F--16568002(+) TCTGGC/TAGTTC 2 -- int11Minor allele frequency- T:0.01NA 120
    rs1455192791,2
    --16568059(+) CGCAAA/GAGAAA 2 -- int10--------
    rs1851419711,2
    --16568078(+) TATGTC/TCACGT 2 -- int10--------
    rs731425131,2
    C--16568122(+) TCTAAC/TAGTTA 2 -- int14Minor allele frequency- T:0.24WA NA EA 360
    rs1381326691,2
    --16568161(+) ACAGAC/TGAATG 2 -- int10--------
    rs1410081061,2
    --16568345(+) AGTAAA/GTAAAT 2 -- int10--------
    rs1448246221,2
    --16568349(+) AGTAAA/GTTAGT 2 -- int10--------
    rs749746681,2
    C--16568367(+) TAGGGA/CTGCAC 2 -- int10--------
    rs1412178951,2
    --16568392(+) TAGCAA/GGTGAC 2 -- int10--------
    rs742828671,2
    C,F--16568490(+) AACCAG/ATGAAA 2 -- int13Minor allele frequency- A:0.22WA NA EA 358
    rs1896048431,2
    --16568573(+) AACACC/TTTCCC 2 -- int10--------
    rs1378671791,2
    --16568619(+) ACCAAA/GTTAGT 2 -- int10--------
    rs731425151,2
    C,F--16568675(+) TTTAGT/GCCTGT 2 -- int12Minor allele frequency- G:0.05WA 120
    rs1819034861,2
    --16568706(+) TAAAAA/CCTGGA 2 -- int10--------
    rs1876407321,2
    C--16568792(+) CCACAC/TTCTCT 2 -- int10--------
    rs1919501641,2
    --16568796(+) ATTCTC/TTTCCA 2 -- int10--------
    rs752012371,2
    C,F--16568802(+) TTCCAC/TTTTAC 2 -- int12Minor allele frequency- T:0.10NA 122
    rs1837745741,2
    C--16568846(+) ACTCAA/GCATTT 2 -- int10--------
    rs749498091,2
    C,F--16568865(+) CACTTT/CACCCC 2 -- int13Minor allele frequency- C:0.22WA NA EA 358
    rs1883057201,2
    --16568966(+) TTGAGA/GCAAGG 2 -- int10--------
    rs1166068591,2
    C,F--16569012(+) CAATCA/GTGGCT 2 -- int11Minor allele frequency- G:0.05WA 118
    rs1494598991,2
    C--16569013(+) AATCAC/TGGCTC 2 -- int10--------
    rs1475238751,2
    --16569108(+) CACAAC/GTGGCT 2 -- int10--------
    rs1125257711,2
    C--16569207(+) GCCCCA/CAAAAG 2 -- int12Minor allele frequency- C:0.25WA CSA 4
    rs1902964871,2
    --16569208(+) CCCCCA/GAAAGT 2 -- int10--------
    rs1825631081,2
    --16569216(+) AGTGCC/TGGGAT 2 -- int10--------
    rs1868161161,2
    --16569262(+) CTTTCA/TGTATC 2 -- int10--------
    rs730350621,2
    C,F--16569333(+) TCAATT/CACAAA 2 -- int14Minor allele frequency- C:0.23WA CSA NA 242
    rs750197041,2
    F--16569384(+) GTCAAG/CGTTCA 2 -- int11Minor allele frequency- C:0.07NA 120
    rs751750451,2
    C--16569543(+) AATTGC/TGCGTA 2 -- int10--------
    rs1473067311,2
    C--16569546(+) TGTGCA/GTAACT 2 -- int10--------
    rs1487764411,2
    C--16569552(+) TAACTC/GTTATA 2 -- int10--------
    rs1912749681,2
    C--16569600(+) GTTTCT/GCAGTC 4 /R syn11Minor allele frequency- G:0.00EU 1321
    rs578420381,2
    C,F--16569672(+) AAACAC/TAGAAG 2 -- int14Minor allele frequency- T:0.13WA NA EA EU 1679
    rs1164186951,2
    C--16569696(+) AAAGAC/TGACTC 2 -- int11Minor allele frequency- T:0.01NA 120
    rs1126668831,2
    C--16569723(+) AAGGGT/-TTTTT 2 -- int11Minor allele frequency- -:0.50CSA 2
    rs3676288491,2
    C--16569724(+) AAGGG-/TTTTTT 2 -- int10--------
    rs1157613311,2
    F--16569798(+) TGGGAG/ATGGTG 2 -- int11Minor allele frequency- A:0.07WA 118
    rs608301501,2
    C--16569810(+) CTCACA/GCCTGT 2 -- int10--------
    rs1837571171,2
    --16569825(+) CCAGCA/CCTTTA 2 -- int10--------
    rs1120518481,2
    C--16569951(+) AGTGGC/TGGGTG 2 -- int12Minor allele frequency- T:0.11WA NA 122
    rs713103531,2
    C,F--16570070(+) CACAGC/AGAGAC 2 -- int12Minor allele frequency- A:0.05NA 122
    rs1512770421,2
    C--16570071(+) ACAGCA/GAGACT 2 -- int10--------
    rs1404227331,2
    --16570136(+) TACCAC/TGTATC 2 -- int10--------
    rs1442394131,2
    C--16570259(+) TATTCA/CGGACA 2 -- int10--------
    rs1158379821,2
    C,F--16570277(+) AAAATT/GACACT 2 -- int11Minor allele frequency- G:0.01NA 120
    rs37738261,2
    C,F,H--16570319(+) AAATCG/AAGTAT 2 -- int114Minor allele frequency- A:0.08EA NS NA 3416
    rs730350631,2
    C,F--16570429(+) GATTCA/GAGAGT 2 -- int14Minor allele frequency- G:0.22WA CSA NA 242
    rs1465152071,2
    C--16570479(+) AAGAAA/CGAACC 2 -- int10--------
    rs575686321,2
    C--16570546(+) TGCCAT/CATATA 2 -- int12Minor allele frequency- C:0.09WA 120
    rs1892525651,2
    --16570551(+) TATATA/GATGTT 2 -- int10--------
    rs1484569001,2
    C--16570571(+) ATGCC-/GTAAGT 2 -- int10--------
    rs730350651,2
    C,F--16570600(+) AGTAAA/GTATCA 2 -- int14Minor allele frequency- G:0.24WA CSA NA 242
    rs1930614231,2
    --16570657(+) TGAAGA/GGTAGA 2 -- int10--------
    rs1854302081,2
    --16570683(+) TTCCCA/GTAACA 2 -- int10--------
    rs1898561501,2
    --16570710(+) TAATAC/TAGTAT 2 -- int10--------
    rs1812681311,2
    --16570724(+) TTGAAG/TTATGG 2 -- int10--------
    rs591675451,2
    C,F--16570772(+) CTGCTG/CAATCA 2 -- int13Minor allele frequency- C:0.22WA NA EA 358
    rs1838339131,2
    --16570787(+) CTTTAC/TGTATA 2 -- int10--------
    rs347954941,2
    C--16570814(+) TATCTG/CAAATT 2 -- int15Minor allele frequency- C:0.22NA WA EA 362
    rs1411529951,2
    --16570895(+) TGCCCA/TGGGTG 2 -- int10--------
    rs597402371,2
    C,F--16570975(+) GCCACC/TGCACC 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1885064661,2
    C--16571191(+) AGAGGA/GTGGAG 4 P S mis10--------
    rs2020235271,2
    --16571260(+) ACAGTG/TGTAGT 4 N H mis10--------
    rs1810152661,2
    --16571391(+) TTGTGC/TTGAAA 2 -- int10--------
    rs1385700441,2
    --16571437(+) GAACAC/GTTGAA 2 -- int10--------
    rs412850451,2
    C,F--16571564(+) TATATC/TCTTCA 2 -- int12Minor allele frequency- T:0.05NA EA 240
    rs2002759881,2
    --16571787(+) CTATC-/AAACAA 2 -- int10--------
    rs731425191,2
    C,F--16571814(+) CATTAC/TGTGGA 2 -- int11Minor allele frequency- T:0.50WA 2
    rs762040941,2
    C,F--16571857(+) AGAAGA/GAGGCA 2 -- int13Minor allele frequency- G:0.07WA NA EA 358
    rs799241241,2
    C,F--16571858(+) GAAGAA/CGGCAC 2 -- int13Minor allele frequency- C:0.07WA NA EA 358
    rs130679971,2
    C,F--16571872(+) TGCTCC/GCATGG 2 -- int18Minor allele frequency- G:0.32NA WA EA 368
    rs1434758551,2
    --16571947(+) AAAATA/GTAGGC 2 -- int10--------
    rs1996436361,2
    --16571991(+) TAAAC-/AAAAAA 2 -- int10--------
    rs1858620961,2
    --16571993(+) AAACAA/GAAAAA 2 -- int10--------
    rs2018742911,2
    --16572038(+) TAATTC/TACTTT 2 -- int10--------
    rs2011200341,2
    --16572042(+) TCACTC/TTACCG 2 -- int10--------
    rs2008940101,2
    --16572049(+) ACCGGA/GGGTAC 4 P syn10--------
    rs1996413411,2
    --16572050(+) CCGGAA/GGTACA 4 P L mis10--------
    rs1924344981,2
    C--16572060(+) AACATA/GGCTCC 4 H Y mis10--------
    rs2000949731,2
    --16572146(+) ACAAAC/TTTTCA 2 -- int10--------
    rs771346971,2
    C,F--16572206(+) TGTTGC/TTATAA 2 -- int11Minor allele frequency- T:0.50WA 2
    rs577523901,2
    C,F--16572209(+) TGTTAT/CAATAA 2 -- int14Minor allele frequency- C:0.22WA CSA NA 242
    rs567408031,2
    C,F--16572217(+) TAAAAG/CAAACA 2 -- int13Minor allele frequency- C:0.22WA NA 240
    rs1116038471,2
    C,F--16572295(+) ACCTTC/TTTCCC 2 -- int12Minor allele frequency- T:0.50CSA 4
    rs730350701,2
    C,F--16572331(+) AATCTC/GAGAGA 2 -- int14Minor allele frequency- G:0.22WA CSA NA 242
    rs117084091,2
    C,H--16572333(+) TCTCAA/GAGATA 2 -- int10--------
    rs46853571,2
    C,F,A,H--16572408(+) AAGAGA/TCTCAA 2 -- int126Minor allele frequency- T:0.26NS EA NA WA CSA 2357
    rs67870631,2
    C,F,A,H--16572471(+) GTGCTC/GTAAGA 2 -- int124Minor allele frequency- G:0.46NS EA NA WA CSA 1639
    rs42345371,2
    C,F,A,H--16572543(+) TCGGCT/CATTTG 2 -- int122Minor allele frequency- C:0.21NS EA NA WA 2766
    rs348653851,2
    C--16572557(+) GCAAA-/GATGAA 2 -- int10--------
    rs23035891,2
    C,F,A,H--16572591(+) GGGGAC/TACCGA 2 -- int114Minor allele frequency- T:0.39EA NA WA CSA 1845
    rs22547831,2
    C,A--16572679(+) ATAAAG/AAGGTC 2 -- int15Minor allele frequency- A:0.22NA WA EA 362
    rs23035901,2
    C,A--16572791(+) TAAAAT/CCTGAA 2 -- int14Minor allele frequency- C:0.22NA WA EA 360
    rs1904445571,2
    --16572981(+) AAAATA/GTGAAA 2 -- int10--------
    rs21951541,2
    C,F,A,H--16573048(+) TTTATG/AAAGAA 2 -- int1 trp34Minor allele frequency- A:0.22NA WA EA 362
    rs799973921,2
    C,F--16573131(+) TTTCAA/GCAGGC 2 -- int11Minor allele frequency- G:0.07WA 118
    rs730350731,2
    C--16573234(+) AAGTTA/CAATTA 2 -- int13Minor allele frequency- C:0.09CSA WA NA 240
    rs1434137971,2
    --16573335(+) ATGGCA/TTTTTC 2 -- int10--------
    rs1119640681,2
    C,F--16573398(+) AAACAG/ATATAA 2 -- int12Minor allele frequency- A:0.50CSA 4
    rs359422391,2
    C,F--16573567(+) GTACAC/ACCTAC 2 -- int14Minor allele frequency- A:0.13NA 126
    rs1471506611,2
    --16573583(+) TCAAGA/TACATG 2 -- int10--------
    rs1173411231,2
    C,F--16573599(+) TGTCAA/GTGAAT 2 -- int11Minor allele frequency- G:0.02EA 120
    rs2019210201,2
    C--16573632(+) CACTC-/CTGTTTT 2 -- int10--------
    rs1132472161,2
    C,F--16573660(+) GCAAAG/AACAAT 2 -- int12Minor allele frequency- A:0.02NA 122
    rs1385275671,2
    --16573677(+) TAAACG/TAAATC 2 -- int10--------
    rs780080851,2
    C,F--16573746(+) CAAATC/GCTACT 2 -- int11Minor allele frequency- G:0.14EA 120
    rs1827207711,2
    --16573750(+) TCCTAC/TTTTAA 2 -- int10--------
    rs1858693511,2
    --16573751(+) CCTACG/TTTAAA 2 -- int10--------
    rs1902413891,2
    --16573952(+) TACTAC/GACAGA 2 -- int10--------
    rs98479011,2
    C--16573968(+) aacgaT/Cagctg 2 -- int12Minor allele frequency- C:0.00NA 4
    rs1460426941,2
    C--16574009(+) GGGGG-/AAAAAG 2 -- int10--------
    rs1473304291,2
    --16574031(+) TTCATA/GTGTCT 2 -- int10--------
    rs1434073431,2
    C--16574092(+) CATAT-/AAAGAA 2 -- int10--------
    rs563981701,2
    C,F--16574100(+) GAACAA/CCACTA 2 -- int12Minor allele frequency- C:0.15WA 120
    rs1829687011,2
    --16574195(+) AATTGA/GATGTA 2 -- int10--------
    rs2017027031,2
    --16574247(+) GGAACA/GTTAAG 2 -- int10--------
    rs1875524861,2
    --16574308(+) TGCATA/GTAAGT 4 Y syn10--------
    rs1153177261,2
    C,F--16574356(+) GGTGGA/GGGAGG 4 P syn11Minor allele frequency- G:0.02WA 118
    rs2009350661,2
    C--16574358(+) TGGAGA/GAGGAT 4 P S mis10--------
    rs2020147721,2
    C--16574366(+) GATGAT/CTAAAA 4 /N /S mis11Minor allele frequency- C:0.00EU 1323
    rs2018142751,2
    C--16574429(+) AAGGCC/ATATTT 2 -- int11Minor allele frequency- A:0.00EU 1315
    rs23035911,2
    C,F--16574473(+) TGTTTA/GAAAAG 2 -- int14Minor allele frequency- G:0.14WA NA EA EU 1523
    rs2012427641,2
    --16574501(+) CTCACA/GTAAAT 4 R C mis10--------
    rs1398405161,2
    C--16574547(+) TTACCA/GTGGAA 4 H syn11Minor allele frequency- G:0.00EU 1311
    rs1498265011,2
    --16574705(+) GTCATC/TATGAA 2 -- int10--------
    rs799088091,2
    C,F--16574759(+) AGTGAA/CAGTTG 2 -- int11Minor allele frequency- C:0.06WA 118
    rs22172041,2
    C,F,O,A,H--16574781(+) TTCATC/TACCCT 2 -- int124Minor allele frequency- T:0.27EA NS NA WA CSA 3457
    rs1447321811,2
    --16574813(+) GTCTGC/TAGTTC 2 -- int10--------
    rs21951551,2
    C,F,O,A--16574816(+) TGTAGT/CTCATG 2 -- int110Minor allele frequency- C:0.22NA EA 610
    rs742088851,2
    C,F--16574969(+) TCAATT/GAAACA 2 -- int14Minor allele frequency- G:0.13WA NA EA EU 1573
    rs2003415571,2
    C--16575029(+) CACGTC/GATTAA 4 H D mis10--------
    rs1485453771,2
    --16575125(+) ATATAC/TGGAAG 2 -- int10--------
    rs741939971,2
    C,F--16575152(+) ATGAAT/CAATAT 2 -- int13Minor allele frequency- C:0.22WA NA EA 358
    rs1932700351,2
    --16575189(+) TGATAG/TATCCT 2 -- int10--------
    rs753113891,2
    --16575371(+) AAACAG/ATTCTT 2 -- int11Minor allele frequency- A:0.01EA 120
    rs731425221,2
    C,F--16575391(+) TGATTA/GATTCA 2 -- int12Minor allele frequency- G:0.04WA 120
    rs1837414851,2
    --16575484(+) CTACAA/TGAAAG 2 -- int10--------
    rs1398103141,2
    C--16575553(+) CTGAT-/ACTC  
            
    TATAC
    2 -- int10--------
    rs2000115331,2
    --16575576(+) GTTCAG/TATATT 2 -- int10--------
    rs2002268851,2
    C--16575588(+) TTGATA/GAAATT 2 -- int11Minor allele frequency- G:0.00EU 1319
    rs1873839661,2
    C--16575745(+) TTTTAA/GTTTTA 2 -- int10--------
    rs37738271,2
    C,F,A,H--16575760(+) AAGAAG/TGTTCG 2 -- int127Minor allele frequency- T:0.44EA NS NA WA CSA 3815
    rs617301171,2
    C,F--16576074(+) CTCTGC/GAGATG 4 S C mis13Minor allele frequency- G:0.03NS CSA 80
    rs117109671,2,,4
    C,F,H--16576081(+) GATGGT/CTGAGT 4 /T /A mis1 ese312Minor allele frequency- C:0.13NS EA NA EU 2051
    rs2003679431,2
    --16576102(+) AGGATG/TTGCAG 4 N H mis10--------
    rs2017874791,2
    C,F--16576136(+) CATCAT/CAATTA 2 -- int11Minor allele frequency- C:0.00EU 1321
    rs67648671,2
    C,A--16576285(+) TTTAAT/CGAAAG 2 -- int14Minor allele frequency- C:0.24WA NA EA 360
    rs1499375941,2
    C--16576315(+) TTTTT-/GA/TGA
            
    GAGAG
    4 -- int1 cds10--------
    rs130653131,2
    C,H--16576326(+) AGTCTT/CGCCCT 2 -- int17Minor allele frequency- C:0.00NS EA NA CSA 400
    rs1400339571,2
    --16576413(+) TGCCTC/TAGCCT 2 -- int10--------
    rs759648821,2
    C--16576417(+) TCAGCC/TTCCTG 2 -- int10--------
    rs763575511,2
    C--16576418(+) CAGCCG/TCCTGA 2 -- int10--------
    rs124863241,2
    C,H--16576450(+) cgacaC/Acacgc 2 -- int11Minor allele frequency- A:0.25NA 4
    rs68008881,2
    C--16576523(+) ACTCCC/TGACCT 2 -- int10--------
    rs1117903251,2
    C--16576697(+) TACTTA/-AAAAA 2 -- int11Minor allele frequency- -:0.00CSA 2
    rs2014227011,2
    --16576705(+) AAAAA-/AAAC  
            
    AAACC
    2 -- int10--------
    rs1512482711,2
    C--16576706(+) AAAAA-/AACAAACC 2 -- int10--------
    rs780149861,2
    C,F--16576768(+) TTCTAT/CATTCA 2 -- int11Minor allele frequency- C:0.06WA 118
    rs730350771,2
    C,F--16576775(+) TTCATA/CAACAA 2 -- int11Minor allele frequency- C:0.04NA 120
    rs1922611841,2
    --16576861(+) AAATAA/CGCCTC 2 -- int10--------
    rs1512239481,2
    --16576947(+) GTTAGC/TATGCC 2 -- int10--------
    rs1843190831,2
    --16576974(+) TGGATC/TATGGA 2 -- int10--------
    rs731425241,2
    C,F--16577131(+) GTAGGC/GAGATA 2 -- int12Minor allele frequency- G:0.05WA 120
    rs1886526851,2
    --16577195(+) TTCTGC/GATTTT 2 -- int10--------
    rs37738281,2
    C--16577226(+) TTTCCG/ACAGTA 2 -- int16Minor allele frequency- A:0.36EA NA WA 1672
    rs37738291,2
    C,F,A,H--16577390(+) CCAGCC/TGTGTA 2 -- int111Minor allele frequency- T:0.34EA NS NA WA 1690
    rs1402492441,2
    --16577424(+) AGGAAA/GTGAGA 2 -- int10--------
    rs1916091861,2
    --16577475(+) ATCAAC/TATAAG 2 -- int10--------
    rs98401011,2
    C--16577487(+) TAGTGC/TCCTGT 2 -- int10--------
    rs1449421711,2
    C--16577566(+) TTGAAA/C/GATACT 2 -- int10--------
    rs1421006061,2
    --16577661(+) AAAGGG/TAACTA 2 -- int10--------
    rs2005045191,2
    C--16577718(+) AGAAA-/ACAAG 
            
    ACAAA
    2 -- int10--------
    rs779625691,2
    F--16577748(+) TCTTTT/CTGAAA 2 -- int11Minor allele frequency- C:0.01WA 118
    rs731425261,2
    C,F--16577760(+) GCACAG/ATAATT 2 -- int12Minor allele frequency- A:0.02WA 120
    rs1845306051,2
    C--16577867(+) TGTCAA/GATCAA 2 -- int10--------
    rs1890488621,2
    --16577870(+) CAAATC/TAACTA 2 -- int10--------
    rs1823991441,2
    --16577891(+) TATTGC/TTTTTC 2 -- int10--------
    rs1458934471,2
    --16578018(+) ACAGTC/TTTTCC 2 -- int10--------
    rs1870270491,2
    --16578036(+) AAATGC/TCTTAC 2 -- int10--------
    rs98249771,2
    C--16578069(+) AGCTGC/G/TGTATC 2 -- int11CSA 1
    rs745255661,2
    C,F--16578090(+) AGGAAC/GCTGAT 2 -- int11Minor allele frequency- G:0.07NA 120
    rs1894411241,2
    --16578102(+) AGATTC/TCCCCC 2 -- int10--------
    rs1817593741,2
    --16578208(+) CTCCTC/TTTCAA 2 -- int10--------
    rs1860171371,2
    --16578579(+) AACCTC/TGTGAC 2 -- int10--------
    rs1903854381,2
    --16578634(+) CTGATA/TTCCAT 2 -- int10--------
    rs577428891,2
    C,F--16578819(+) GTCTGA/TCTTTG 2 -- int12Minor allele frequency- T:0.09WA 120
    rs1166085451,2
    C,F--16578881(+) ATTCAT/CAGGAT 2 -- int11Minor allele frequency- C:0.02NA 120
    rs1386197431,2
    --16578942(+) TAGTTC/GTCAGC 2 -- int10--------
    rs1828345611,2
    --16578944(+) GTTCTC/GAGCCA 2 -- int10--------
    rs622346961,2
    C,F--16578984(+) GCAATG/ATACTT 2 -- int11Minor allele frequency- A:0.50NA 2
    rs1995083241,2
    C--16579045(+) TATAC-/ATAATT
            
    ATAAT
    2 -- int10--------
    rs731425291,2
    C--16579087(+) GACAAA/CCTTTG 2 -- int14Minor allele frequency- C:0.24WA NA EA 360
    rs1861724671,2
    C--16579177(+) GTCAAC/TAGCAT 2 -- int10--------
    rs38217081,2
    C,F,A,H--16579255(+) GAAATG/CAGAAA 2 -- int19Minor allele frequency- C:0.33NA WA EA 370
    rs1378781491,2
    C--16579276(+) TAAAC-/AGGGGTG 2 -- int10--------
    rs1433700641,2
    C--16579313(+) TCTCAC/TTGTTA 2 -- int10--------
    rs98506991,2
    C--16579393(+) ATTATG/TATGTA 2 -- int10--------
    rs37738301,2
    C,F,A,H--16579406(+) TCCTGG/CGATGT 2 -- int19Minor allele frequency- C:0.32NA WA EA 370
    rs1508880361,2
    --16579505(+) ATAATC/TTGTAG 2 -- int10--------
    rs1905993021,2
    --16579555(+) AAAGAA/GAATGC 2 -- int10--------
    rs1396012361,2
    --16579560(+) GAATGC/TTAAAA 2 -- int10--------
    rs1428308821,2
    --16579578(+) AATATC/GACATG 2 -- int10--------
    rs1828001091,2
    --16579619(+) AAGAGC/TAGATT 2 -- int10--------
    rs1460953541,2
    --16579625(+) AGATTA/CTTGGG 2 -- int10--------
    rs1400027751,2
    C--16579720(+) TATGAA/GACCTG 2 -- int10--------
    rs37738311,2
    C,F--16579728(+) CTGAGA/GAATGG 2 -- int13Minor allele frequency- G:0.06EA NA 1728
    rs1879421571,2
    --16579889(+) TGGGAG/TTTTTT 2 -- int10--------
    rs37738321,2
    C,F,H--16579947(+) AGAGGT/GGCACA 2 -- int121Minor allele frequency- G:0.27EA NS NA WA 3818
    rs37738331,2
    C,F,A--16579995(+) GAAGAA/GGAGAT 2 -- int1 trp313Minor allele frequency- G:0.25EA NA WA CSA 1839
    rs1435909021,2
    C--16580112(+) GCCATA/CCCTGC 2 -- int10--------
    rs76499721,2
    C,A,H--16580137(+) CAAAAT/CTCCAG 2 -- int14Minor allele frequency- C:0.00NS EA 418
    rs1924042851,2
    --16580180(+) TGCAAA/GAATAC 2 -- int10--------
    rs46853581,2
    C,A--16580216(+) CACCAC/TTGAAA 2 -- int14Minor allele frequency- T:0.28WA NA EA 360
    rs588690031,2
    C,F--16580452(+) GTCTTT/CATGAA 2 -- int13Minor allele frequency- C:0.21WA NA EA 358
    rs731425321,2
    C,F--16580543(+) CAACAT/CAGTAA 2 -- int12Minor allele frequency- C:0.05WA 120
    rs1830002951,2
    --16580550(+) GTAAAA/GTATTT 2 -- int10--------
    rs570142211,2
    C,F--16580565(+) GCTATT/CAGGTT 2 -- int13Minor allele frequency- C:0.21WA NA EA 358
    rs568414781,2
    C,F--16580578(+) CAATTC/AAAAAA 2 -- int13Minor allele frequency- A:0.22WA NA EA 358
    rs738184741,2
    C,F--16580658(+) TGATAC/TATTCT 2 -- int11Minor allele frequency- T:0.50WA 2
    rs1872493891,2
    --16580665(+) TTCTTC/TACACC 2 -- int10--------
    rs111287981,2
    C,F,A,H--16580696(+) GTATCA/GTAATT 2 -- int19Minor allele frequency- G:0.32NA WA EA 370
    rs750938631,2
    F--16580701(+) ATAATT/CTGATA 2 -- int11Minor allele frequency- C:0.05WA 118
    rs1929527141,2
    --16580764(+) CAAAGA/GGGTAA 2 -- int10--------
    rs786637351,2
    C,F--16580771(+) GTAAAG/ACGCTT 2 -- int11Minor allele frequency- A:0.06WA 118
    rs1845504861,2
    --16580780(+) TTTCAA/CCCAGC 2 -- int10--------
    rs1894832301,2
    --16580838(+) GCCAAA/GATATT 2 -- int10--------
    rs1426085491,2
    --16580841(+) AAGATA/GTTTAC 2 -- int10--------
    rs353208831,2
    C--16580865(+) TAGCA-/TTTTTT 2 -- int10--------
    rs561052361,2
    C--16580875(+) TTTTT-/T/TTT 
            
    GAGAC
    2 -- int11NA 2
    rs1924965201,2
    --16580903(+) GTTGCC/TTAGGC 2 -- int10--------
    rs730350801,2
    C,F--16581007(+) AGTGCG/ACACCA 2 -- int14Minor allele frequency- A:0.21WA CSA NA 242
    rs2004892651,2
    C--16581031(+) AATTT-/TCCTGTT 2 -- int10--------
    rs731425341,2
    C,F--16581042(+) TTTAGT/CAGCGA 2 -- int12Minor allele frequency- C:0.04WA 120
    rs1406878311,2
    C--16581068(+) TAGCC-/AAGGCT 2 -- int10--------
    rs730350821,2
    C,F--16581106(+) CCACCC/TGCCTC 2 -- int12Minor allele frequency- T:0.50WA CSA 4
    rs1844755121,2
    --16581123(+) CTAAAC/GAGATT 2 -- int10--------
    rs1145512071,2
    F--16581127(+) AGAGAT/CTGATT 2 -- int11Minor allele frequency- C:0.01WA 118
    rs756336151,2
    C,F--16581162(+) CCCATG/CATAGT 2 -- int11Minor allele frequency- C:0.06EA 120
    rs796704751,2
    F--16581209(+) AATTCG/AGTAAA 2 -- int11Minor allele frequency- A:0.03WA 118
    rs1895829691,2
    --16581318(+) AGCACA/GGTGTA 2 -- int10--------
    rs1818860831,2
    --16581328(+) AACTCC/TTGTAA 2 -- int10--------
    rs37738341,2
    C,A,H--16581561(+) ACTTAT/CAACTC 2 -- int110Minor allele frequency- C:0.21NA WA CSA EA 370
    rs1861594661,2
    --16581613(+) ACAATC/TACACA 2 -- int10--------
    rs746162271,2
    C,F--16581667(+) TAAACT/CGTGTA 2 -- int11Minor allele frequency- C:0.07NA 120
    rs731425361,2
    C,F--16581690(+) CTGAAG/AAGACT 2 -- int12Minor allele frequency- A:0.04WA 120
    rs771100371,2
    C,F--16581877(+) ATCCTG/CGTTTA 2 -- int13Minor allele frequency- C:0.21WA NA EA 358
    rs1458285051,2
    C--16581887(+) ATCGAA/GAGGGA 2 -- int10--------
    rs1143093151,2
    C,F--16581961(+) GTGCGA/G/TCAAAG 4 T P S int1 mis11WA 118
    rs731425391,2
    C,F--16581979(+) CAGGCG/AAGCTT 3 /R /C int1 mis11Minor allele frequency- A:0.03WA 118
    rs1889666801,2
    C--16581999(+) CGCCAC/TACGAG 3 Y C int1 mis10--------
    rs21626161,2
    C,F,A,H--16582200(+) CCCTCG/TAAGTT 2 -- int1 ut5120Minor allele frequency- T:0.27NS EA NA CSA WA 2343
    rs1151524651,2
    F--16582458(+) ACGTGG/ACCGGC 2 -- int1 us2k11Minor allele frequency- A:0.07WA 118
    rs1411239601,2
    C--16582479(+) GTCCTC/TGGGGC 2 -- int1 us2k10--------
    rs731425411,2
    C,F--16582508(+) CCTTGG/ACGTCC 2 -- int1 us2k11Minor allele frequency- A:0.07WA 118
    rs1813805091,2
    --16582510(+) TTGGCA/GTCCCG 2 -- int1 us2k10--------
    rs1861923931,2
    C,F--16582645(+) GACCCT/CGCAGA 2 -- int1 us2k11Minor allele frequency- C:0.00EU 591
    rs731425421,2
    C,F--16582654(+) GAGCCG/CAGTTT 2 -- int1 us2k12Minor allele frequency- C:0.09WA 120
    rs1503084111,2
    C--16582706(+) TCTCCC/GTCAAC 2 -- int1 us2k10--------
    rs2015946251,2
    C--16582745(+) CCGACA/C/GGGCTC 3 -- ut51 us2k10--------
    rs560793311,2
    C,F--16582746(+) CGACCG/AGCTCC 2 -- ut51 us2k11Minor allele frequency- A:0.01EU 1185
    rs98473421,2
    C,F,H--16582751(+) GGCTCG/CAGGAG 2 -- ut51 us2k110Minor allele frequency- C:0.07NA WA CSA EA EU 1448
    rs2004295821,2
    --16582757(+) AGGAGA/GAGCAG 2 -- ut51 us2k10--------
    rs31777451,2
    C--16582804(-) CAGCGG/AACCTC 2 -- ut51 us2k14Minor allele frequency- A:0.04NA WA 124
    rs1161724311,2
    C,F--16582806(+) GGTCCG/ACTGGA 2 -- ut51 us2k11Minor allele frequency- A:0.03NA 120
    rs1914069331,2
    --16582895(+) AGGAGC/TCCCGA 2 -- ut51 us2k10--------
    rs78431097