Aliases for DAZL Gene
External Ids for DAZL Gene
Previous HGNC Symbols for DAZL Gene
Previous GeneCards Identifiers for DAZL Gene
The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
GeneCards Summary for DAZL Gene
DAZL (Deleted In Azoospermia-Like) is a Protein Coding gene. Diseases associated with DAZL include azoospermia and paraneoplastic syndromes. Among its related pathways are Translational Control and Ovarian Infertility Genes. GO annotations related to this gene include RNA binding and translation activator activity. An important paralog of this gene is DAZ4.
UniProtKB/Swiss-Prot for DAZL Gene
RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).