DAZL Gene

Aliases
for DAZL gene

Previous GC identifer: GC03M016557

Summaries
for DAZL gene

Genomic Views
for DAZL gene

RefSeq DNA sequence:

NC_000003.11  NC_018914.1  NT_022517.18  

SwitchGear Promoter luciferase reporter plasmid: DAZL promoter sequence

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAZL

DAZL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M016603:  view genomic region     (about GC identifiers)

Proteins
for DAZL gene

Explore the universe of human proteins at neXtProt for DAZL: NX_Q92904

Post-translational modifications:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: DAZL OriGene Protein Over-expression Lysate (see all 2): DAZL OriGene Custom Protein Services for DAZL
	GenScript Custom Purified and Recombinant Proteins Services for DAZL
	Novus Biologicals DAZL Protein Novus Biologicals DAZL Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DAZL

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DAZL
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for DAZL
	OriGene Antibodies (see all 2): DAZL OriGene Custom Antibody Services for DAZL
	GenScript Superior Antibodies for DAZL
	Novus Biologicals DAZL Antibodies
	Abcam antibodies for DAZL
	Uscn Antibodies for DAZL
	ThermoFisher Antibodies for DAZL

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DAZL
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DAZL

Protein Domains /
Families
for DAZL gene

ProtoNet protein and cluster: Q92904

Function
for DAZL gene

miRNA Products:		OriGene 3'-UTR Clone: DAZL Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAZL
		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate DAZL (see all 22):
		hsa-miR-3938 hsa-miR-607 hsa-miR-3664-5p hsa-miR-4328 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-629
		SwitchGear 3'UTR luciferase reporter plasmid: DAZL 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAZL (see all 7) OriGene shRNA RFP: DAZL OriGene siRNA: DAZL
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAZL

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for DAZL

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAZL (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DAZL (see all 2) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): DAZL (NM_001351)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAZL
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAZL

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DAZL
		Search LifeMap BioReagents cell lines for DAZL

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAZL

Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

(inferred from 1 allele) (MGI details for Dazl)

Pathways & Interactions
for DAZL gene

	Super-pathway	contained gene-specific pathways
1	Ovarian Infertility Genes	Ovarian Infertility Genes 1.00
2	Translational Control	Translational Control 1.00

1 Cell Signaling Technology (CST) Pathway for DAZL

Translational Control

1 BioSystems Pathway for DAZL

Ovarian Infertility Genes

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

Drugs & Compounds
for DAZL gene

Transcripts
for DAZL gene

Expression
for DAZL gene

DAZL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATAAAAATA

3 LifeMap In Vivo Development Anatomical Compartments/Cells
	Tissue Anatomical Compartment Cell			Category (developmental path)
	Reproductive SystemEarly GonadPrimordial Germ Cells			Germ Cells
	OvaryOvigerous CordXX Germ Cells			Female Gametocytes, Germ Cells
	TestisSeminiferous TubulesSpermatogonium Type A			Germ Cells, Male Gametocytes
Expression: Positive    Negative     Selective marker Experimental details: Curated     Microarrays     In-situ hybridization
Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11)
	Name			Category
	Ovarian tissue-dissociated cells (Primary Cell)			Reproductive System
	Ovarian tissue-dissociated cells (human) (Primary Cell)			Ovary, Reproductive System
	ES-J1 (Embryonic Stem Cell)			Early Embryo, Inner Cell Mass
	Primordial germ-like cells (Derivation of embryo...)
	Embryoid bodies (Derivation of post-m...)
	Primordial-like germ cells (cKIT+ SSEA1+ VASA+) (Derivation of primor...)
	Embryoid bodies (Derivation of embryo...)
	Short-term differentiated embryoid bodies (Derivation of embryo...)
	Primordial germ cell-like cells (Reconstitution of mo...)
	Human oogonial stem cells (Oocyte formation by ...)

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DAZL Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT2 qPCR Primer Assay in human, mouse / rat DAZL
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAZL
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAZL

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAZL

Orthologs
for DAZL gene

Paralogs
for DAZL gene

Paralogs for DAZL gene

DAZ1²  DAZ3²  DAZ4²  DAZ2²  BOLL²  

8 SIMAP similar genes for DAZL using alignment to 3 protein entries:     DAZL_HUMAN (see all proteins):

DAZ3    DAZ4    DAZ2    DAZ1    BOLL    RBMY1A1

RBFOX2    HNRNPA2B1

DAZL for paralogs           About GeneDecksing


4 Pseudogenes.org Pseudogenes for DAZL
PGOHUM00000233822 PGOHUM00000233854 PGOHUM00000234035 PGOHUM00000234068

Genomic Variants
for DAZL gene

10/450 NCBI SNPs in DAZL are shown (see all 450)     About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 3 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs610935751,2		--	16561649(+)	ATTGGG/TAGTAC	2	--	int1		0	--	--	--	--
rs751483541,2	F,	--	16561708(+)	CATCCA/GTAAGA	2	--	int1		1		WA	118
rs170424401,2	C,F,,	--	16561754(+)	GCAACC/TGCAAT	2	--	int1		3		NA	138
rs105104531,2	C,F,H,	--	16561797(+)	AAAGCG/ATACAG	2	--	int1		104		NS NA EA PA EU CA WA CSA	6304
rs731425091,2	C,	--	16562740(+)	TCTTTA/GTATCA	2	--	ut31		2		WA	120
rs556797521,2	C	--	16562808(+)	GTGGTG/-ATAGC	2	--	ut31		1		NA	2
rs774289561,2	C,F,	--	16563381(+)	GGACTG/ATTCGC	2	--	ut31		1		WA	118
rs170424431,2	C,F,H,	--	16563592(+)	ACCAAC/GAAAAT	2	--	ut31		8		NA NS EA WA	662
rs123741511,2	C,F,H,	--	16564278(+)	TTTATG/ATACTT	2	--	int1		15		NS EA NA	1740
rs1136611981,2	F	--	16564996(+)	AAACTC/TTGGGA	2	--	int1		2		CSA	4

HapMap Linkage Disequilibrium report for DAZL (16628299 - 16711813 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for DAZL
     3 CNVs: 68344 68343 68341
Human Gene Mutation Database (HGMD): DAZL

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DAZL

DNA2.0 Custom Variant and Variant Library Synthesis for DAZL

Disorders / Diseases
for DAZL gene

20 diseases for DAZL

10/16 Novoseek disease relationships for DAZL gene (see all 16)    About this table

Publications
for DAZL gene

PubMed articles for DAZL gene, integrated from 9 sources (see all 154) (see top 10): (articles sorted by number of sources associating them with DAZL)

Utopia: connect your pdf to the dynamic world of online information

1. Association of a single-nucleotide polymorphism of the deleted-in- azoospermia-like gene with susceptibility to spermatogenic failure. (PubMed id 12414900)^{1, 2, 4} Teng Y.-N.... Kuo P.-L. (2002)
2. The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. (PubMed id 8896558)^{1, 2, 3} Saxena R....Page D.C. (1996)
3. A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad. (PubMed id 8968755)^{1, 2, 9} Shan Z.... Vogt P.H. (1996)
4. A putative human male infertility gene DAZLA: genomic structure and methylation status. (PubMed id 9294855)^{1, 2, 9} Chai N.-N.... Yen P.H. (1997)
5. The human autosomal gene DAZLA: testis specificity and a candidate for male infertility. (PubMed id 8968756)^{1, 2, 9} Yen P.H.... Salido E.C. (1996)
6. Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PubMed id 10857750)^{1, 2, 9} Tsui S.... Yen P.H. (2000)
7. Survey of the two polymorphisms in DAZL, an autosomal candidate for the azoospermic factor, in Japanese infertile men and implications for male infertility. (PubMed id 16123080)^{1, 4, 9} Yang X.J....Nakahori Y. (2005)
8. A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. (PubMed id 11390979)^{1, 2, 9} Xu E.Y.... Reijo Pera R.A. (2001)
9. No association of the A260G and A386G DAZL single nucleotide polymorphisms with male infertility in a Caucasian population. (PubMed id 15520024)^{1, 4, 9} Tschanter P....Gromoll J. (2004)
10. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)^{1, 2, 9} Moore F.L.... Reijo Pera R.A. (2003)
11. DAZL polymorphisms and susceptibility to spermatogenic failure: an example of remarkable ethnic differences. (PubMed id 15595957)^{1, 4} Becherini L....Krausz C. (2004)
12. Lack of the T54A polymorphism of the DAZL gene in infertile Italian patients. (PubMed id 15220464)^{1, 4} Bartoloni L....Foresta C. (2004)
13. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
14. Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene. (PubMed id 9143498)^{1, 9} Seboun E....Algonik A. (1997)
15. DAZL expression in human oocytes, preimplantation embryos and embryonic stem cells. (PubMed id 15879466)^{1, 9} Cauffman G....Van Steirteghem A. (2005)
16. Association of the mouse infertility factor DAZL1 with actively translating polyribosomes. (PubMed id 10819768)^{1, 9} Tsui S....Yen P.H. (2000)
17. Conserved and divergent patterns of expression of DAZL, VASA and OCT4 in the germ cells of the human fetal ovary and testis. (PubMed id 18088417)^{1, 9} Anderson R.A....Saunders P.T. (2007)
18. Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men. (PubMed id 16884537)^{1, 9} Tung J.Y....Reijo-Pera R.A. (2006)
19. Expression of DAZL protein in the human corpus luteum. (PubMed id 12029071)^{1, 9} Pan H.A....Kuo P.L. (2002)
20. Localization of a specific germ cell marker, DAZL1, in testicular germ cell neoplasias. (PubMed id 11956819)^{1, 9} Lifschitz-Mercer B....Maymon B.B. (2002)
21. The DAZL1 gene is expressed in human male and female embryonic gonads before meiosis. (PubMed id 10775651)^{1, 9} Brekhman V....Seligman J. (2000)
22. Human DAZL1 encodes a candidate fertility factor in women that localizes to the prenatal and postnatal germ cells. (PubMed id 10527983)^{1, 9} Dorfman D.M....Reijo Pera R.A. (1999)
23. Phenotypic Expression of Partial AZFc Deletions is Independent of the Variations in DAZL and BOULE in a Han Population. (PubMed id 19342699)^{1, 9} Chen P....Yang Y. (2009)
24. Dynamic subcellular distribution of the DAZL protein is confined to primate male germ cells. (PubMed id 10819456)^{1, 9} Ruggiu M....Cooke H.J. (2000)
25. Follicle-stimulating hormone receptor and DAZL gene polymorphisms do not affect the age of menopause. (PubMed id 18178196)^{1, 9} Zerbetto I....Petraglia F. (2008)
26. A to G transitions at 260, 386 and 437 in DAZL gene are not associated with spermatogenic failure in Indian population. (PubMed id 16573709)^{1, 9} Thangaraj K....Singh L. (2006)
27. Association of DAZL haplotypes with spermatogenic failure in infertile men. (PubMed id 16730721)^{1, 9} Teng Y.N....Kuo P.L. (2006)
28. Presence of DAZL transcript and protein in mature human spermatozoa. (PubMed id 11872225)^{1, 9} Lin Y.M....Kuo P.L. (2002)
29. Expression patterns and transcript concentrations of the autosomal DAZL gene in testes of azoospermic men. (PubMed id 11675467)^{1, 9} Lin Y.M....Kuo P.L. (2001)
30. The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis. (PubMed id 9288969)^{1, 9} Ruggiu M....Cooke H.J. (1997)
31. [Autosomal DAZL single nucleotide polymorphisms not associated with male infertility in northeast China] (PubMed id 17918711)^{1, 9} Wen X.H....Wu W. (2007)
32. Expression profiles of the DAZ gene family in human testis with and without spermatogenic failure. (PubMed id 15066460)^{1, 9} Kuo P.L....Hsu C.C. (2004)
33. The expression of DAZL1 in the ovary of the human female fetus. (PubMed id 10689024)^{1, 9} Tsai M.Y....Lu Y.J. (2000)
34. Variants in Deleted in AZoospermia-Like (DAZL) are correlated with reproductive parameters in men and women. (PubMed id 16328470)^{1, 9} Tung J.Y....Pera R.A. (2006)
35. The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells. (PubMed id 16001084)^{1, 9} Collier B....Gray N.K. (2005)
36. In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein. (PubMed id 10903443)^{1, 9} Ruggiu M. and Cooke H.J. (2000)
37. Existence of human DAZLA protein in the cytoplasm of human oocytes. (PubMed id 10340994)^{1, 9} Nishi S....Fujimoto S. (1999)
38. Human DAZL, DAZ and BOULE genes modulate primordial g erm-cell and haploid gamete formation. (PubMed id 19865085)^{1, 9} Kee K....Reijo Pera R.A. (2009)
39. A386G polymorphism of the DAZL gene is not associated with idiopathic male infertility in North India. (PubMed id 19881148)^{1, 9} Singh K. and Raman R. (2009)
40. Deleted in Azoospermia-Like (DAZL) gene-expressing cells in human amniotic fluid: a new source for germ cells research? (PubMed id 18023443)^{1, 9} Stefanidis K....Antsaklis A. (2008)
41. Partial rescue of the Dazl knockout mouse by the human DAZL gene. (PubMed id 12200456)^{1, 9} Vogel T....Cooke H.J. (2002)
42. DAZLA: an important candidate gene in male subfertility? (PubMed id 11499325)^{1, 9} Van Golde R.J....Hoefsloot L.H. (2001)
43. DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice. (PubMed id 11058556)^{1, 9} Reijo R.A.... Page D.C. (2000)
44. A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype. (PubMed id 10393944)^{1, 9} Slee R....Cooke H.J. (1999)
45. A single-nucleotide polymorphism of the DAZL gene prom oter confers susceptibility to spermatogenic failure in the Taiwanese Han. (PubMed id 22752612)¹ Teng Y.N....Kuo P.L. (2012)
46. Divergent RNA-binding proteins, DAZL and VASA, induce meiotic progression in human germ cells derived in vitro. (PubMed id 22162380)¹ Medrano J.V....Reijo Pera R.A. (2012)
47. DAZL 260A > G and MTHFR 677C > T variants in spe rm DNA of infertile Indian men. (PubMed id 22329245)¹ Kumar K....Dada R. (2011)
48. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
49. Incorrect DNA methylation of the DAZL promoter CpG is land associates with defective human sperm. (PubMed id 20685756)¹ Navarro-Costa P....Plancha C.E. (2010)
50. The dazzle in germ cell differentiation. (PubMed id 20008336)¹ Kerr C.L. and Cheng L. (2010)
51. Quantitative trait analysis suggests human DAZL may b e involved in regulating sperm counts and motility. (PubMed id 20462796)¹ Hsu C.C....Kuo P.L. (2010)
52. A method for isolating pluripotent/multipotent stem c ells from blood by using the pluripotent and germ-line DAZL gene as a marker. (PubMed id 19327014)¹ Seligman J....Fabian I. (2009)
53. Gene polymorphisms and male infertility--a meta-analysis and literature review. (PubMed id 18062861)¹ Tuttelmann F....Simoni M. (2007)
54. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)² Bechtel S.... Schupp I. (2007)
55. A germline-specific class of small RNAs binds mammali an Piwi proteins. (PubMed id 16751776)¹ Girard A....Carmell M.A. (2006)
56. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
57. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)² Muzny D.M....Gibbs R.A. (2006)
58. Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind. (PubMed id 15607425)¹ Fox M.... Reijo Pera R.A. (2005)
59. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)² Ota T.... Sugano S. (2004)
60. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
61. Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations. (PubMed id 9700189)¹ Agulnik A.I....Bishop C.E. (1998)
62. (PubMed id 16051679)⁴ 
63. Evolutionary comparison of the reproductive genes, DAZL and BOULE, in primates with and without DAZ. (PubMed id 16425031)⁹ Tung J.Y....Gromoll J. (2006)
64. Expression of DAZ (deleted in azoospermia), DAZL1 (DAZ-like) and protamine-2 in testis and its application for diagnosis of spermatogenesis in non-obstructive azoospermia. (PubMed id 9783841)⁹ Lee J.H....Yoon H.S. (1998)
65. Porcine DAZL messenger RNA: its expression and regula tion during oocyte maturation. (PubMed id 19540306)⁹ Liu J....Li J. (2009)
66. The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation. (PubMed id 9588208)⁹ Seligman J. and Page D.C. (1998)
67. Genomic structure and transcript variants of the bovine DAZL gene. (PubMed id 17268180)⁹ Liu W.S....Ponce de Leon F.A. (2007)
68. Conservation of the deleted-in-azoospermia-like-1 (DAZL1) gene structure in old world monkeys points to a homologous function of DAZL1 in this primate class. (PubMed id 11079458)⁹ Grossmann B....Vogt P.H. (2000)
69. CDC25 protein expression and interaction with DAZL in human corpus luteum. (PubMed id 19006796)⁹ Pan H.A....Kuo P.L. (2009)
70. A386G transition in DAZL gene is not associated with spermatogenic failure in Tamil Nadu, South India. (PubMed id 20300286)⁹ Poongothai J....Manonayaki S. (2008)
71. DAZL binds to the transcripts of several Tssk genes in germ cells. (PubMed id 18452650)⁹ Zeng M....Ma Y. (2008)
72. Cloning and expression of medaka dazl during embryogenesis and gametogenesis. (PubMed id 16979959)⁹ Xu H....Hong Y. (2007)
73. Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype. (PubMed id 10601091)⁹ Vogel T....Cooke H.J. (1999)
74. Boule is present in fish and bisexually expressed in adult and embryonic germ cells of medaka. (PubMed id 19564913)⁹ Xu H....Hong Y. (2009)
75. cynDAZLA: a cynomolgus monkey homologue of the human autosomal DAZ gene. (PubMed id 9239736)⁹ Carani C....Nieschlag E. (1997)
76. Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL. (PubMed id 11604102)⁹ Dai T....Yen P.H. (2001)
77. The Old World monkey DAZ (Deleted in AZoospermia) gene yields insights into the evolution of the DAZ gene cluster on the human Y chromosome. (PubMed id 10484770)⁹ Gromoll J....Nieschlag E. (1999)
78. Mouse autosomal homolog of DAZ, a candidate male sterility gene in humans, is expressed in male germ cells before and after puberty. (PubMed id 8661148)⁹ Reijo R....Page D.C. (1996)
79. Isolation of a sequence-specific RNA binding protein, polypyrimidine tract binding protein, using RNA affinity chromatography. (PubMed id 18982280)⁹ Sharma S. (2008)
80. [Analysis of an AZFc deletion family with natural transmission] (PubMed id 16970164)⁹ Xia X.Y....Wang X.L. (2006)
81. Case report: natural transmission of an AZFc Y-chromosomal microdeletion from father to his sons. (PubMed id 15016778)⁹ Kuhnert B....Nieschlag E. (2004)
82. Cell-specific RNA-binding proteins in human disease. (PubMed id 12837581)⁹ Musunuru K. (2003)
83. The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies. (PubMed id 8558240)⁹ Buckanovich R.J....Darnell R.B. (1996)
84. An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysis. (PubMed id 8026476)⁹ Herschlag D....Karpel R.L. (1994)
85. The lentivirus regulatory proteins REV and REX are site specific RNA binding proteins. (PubMed id 1666813)⁹ Farrington G.K....Rusche J. (1991)
86. Prostaglandin E2 as a regulator of germ cells during ovarian development. (PubMed id 19602557)⁹ Bayne R.A....Anderson R.A. (2009)
87. Molecular characterization and SNPs analysis of the porcine Deleted in AZoospermia Like (pDAZL) gene. (PubMed id 18620821)⁹ Zhang Y.H....Li F.E. (2009)
88. Transposition of two amino acids changes a promiscuous RNA binding protein into a sequence-specific RNA binding protein. (PubMed id 18000034)⁹ Garrey S.M....Berglund J.A. (2008)
89. Expression of pluripotent stem cell markers in the human fetal testis. (PubMed id 18024420)⁹ Kerr C.L....Gearhart J.D. (2008)
90. Evolution of the DAZ gene and the AZFc region on primate Y chromosomes. (PubMed id 18366765)⁹ Yu Y.H....Yen P.H. (2008)
91. Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2. (PubMed id 18664619)⁹ Anderton J.A....Clifford S.C. (2008)
92. Functional and mechanistic insights from genome-wide studies of splicing regulation in the brain. (PubMed id 18380345)⁹ Ule J. and Darnell R.B. (2007)
93. RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB. (PubMed id 17938241)⁹ Kim J.H. and Richter J.D. (2007)
94. Regulated Pumilio-2 binding controls RINGO/Spy mRNA translation and CPEB activation. (PubMed id 16418484)⁹ Padmanabhan K. and Richter J.D. (2006)
95. Evaluation of DAZ microdeletions in 34 infertile men. (PubMed id 16574598)⁹ Abdelmoula N.B....Rebai T. (2006)
96. Heritable and stable gene knockdown in rats. (PubMed id 16844779)⁹ Dann C.T....Garbers D.L. (2006)
97. CPEB controls oocyte growth and follicle development in the mouse. (PubMed id 17050619)⁹ Racki W.J. and Richter J.D. (2006)
98. Post-transcriptional control in the male germ line. (PubMed id 15705295)⁹ Ehrmann I. and Elliott D.J. (2005)
99. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. (PubMed id 16228988)⁹ Ezeh U.I....Clark A.T. (2005)
100. The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway. (PubMed id 15737929)⁹ Costa A....Jongens T.A. (2005)
101. Interaction of the conserved meiotic regulators, BOULE (BOL) and PUMILIO-2 (PUM2). (PubMed id 15806553)⁹ Urano J....Reijo Pera R.A. (2005)
102. Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries. (PubMed id 16209998)⁹ Pan H.A....Kuo P.L. (2005)
103. Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition. (PubMed id 16213216)⁹ Huang C.S....Jan L.Y. (2005)
104. Spatio-temporal expression of a DAZ-like gene in the Japanese newt Cynops pyrrhogaster that has no germ plasm. (PubMed id 15490230)⁹ Tamori Y....Wakahara M. (2004)
105. Putative biological functions of the DAZ family. (PubMed id 15139965)⁹ Yen P.H. (2004)
106. Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. (PubMed id 15081113)⁹ Moore F.L.... Reijo-Pera R.A. (2004)
107. Molecular genetics of human male infertility: from genes to new therapeutic perspectives. (PubMed id 14965334)⁹ Vogt P.H. (2004)
108. Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. (PubMed id 12808107)⁹ Dredge B.K. and Darnell R.B. (2003)
109. Interactions of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its domains with high-affinity binding sites. (PubMed id 12406575)⁹ Kamei D. and Yamada M. (2002)
110. Single-nucleotide variant in multiple copies of a deleted in azoospermia (DAZ) sequence - a human Y chromosome quantitative polymorphism. (PubMed id 11901266)⁹ Szmulewicz M.N....Herrera R.J. (2002)
111. A novel, rapid, and accurate method for detecting microdeletion involving the DAZ gene in infertile men. (PubMed id 10685522)⁹ Lucas H....Bienvenu T. (2000)
112. A critical role for Xdazl, a germ plasm-localized RNA, in the differentiation of primordial germ cells in Xenopus. (PubMed id 10631166)⁹ Houston D.W. and King M.L. (2000)
113. HuD, a neuronal-specific RNA-binding protein, is a putative regulator of N-myc pre-mRNA processing/stability in malignant human neuroblasts. (PubMed id 10348344)⁹ Lazarova D.L....Ross R.A. (1999)
114. Nucleolin: a multifunctional major nucleolar phosphoprotein. (PubMed id 9918513)⁹ Tuteja R. and Tuteja N. (1998)
115. A Xenopus DAZ-like gene encodes an RNA component of germ plasm and is a functional homologue of Drosophila boule. (PubMed id 9486791)⁹ Houston D.W....King M.L. (1998)
116. ANOVA, a putative astrocytic RNA binding protein gene that maps to chromosome 19q13.3. (PubMed id 10735272)⁹ Ueki K.... Louis D.N. (1997)
117. HuD, a neuronal-specific RNA-binding protein, is a potential regulator of MYCN expression in human neuroblastoma cells. (PubMed id 9516855)⁹ Ross R.A....Biedler J.L. (1997)
118. Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. (PubMed id 9344654)⁹ Fletcher C.F....Darnell R.B. (1997)
119. Expression of Hel-N1 and Hel-N2 in small-cell lung carcinoma. (PubMed id 8619556)⁹ King P.H. and Dropcho E.J. (1996)
120. Nucleolin is a sequence-specific RNA-binding protein: characterization of targets on pre-ribosomal RNA. (PubMed id 8676391)⁹ Ghisolfi-Nieto L....Bouvet P. (1996)
121. The HuD paraneoplastic protein shares immunogenic regions between PEM/PSN patients and several strains and species of experimental animals. (PubMed id 8982120)⁹ Sillevis Smitt P....Posner J. (1996)
122. Purification and properties of HuD, a neuronal RNA-bi nding protein. (PubMed id 8626712)⁹ Chung S....Furneaux H. (1996)
123. Accumulation of sequence-specific RNA-binding protein s in the cytosol of activated T cells undergoing RNA degradation and apoptosis. (PubMed id 7592882)⁹ Mondino A. and Jenkins M.K. (1995)
124. Tissue-specific expression of the gene encoding a mouse RNA binding protein homologous to human HuD antigen. (PubMed id 8535975)⁹ Abe R....Sakamoto H. (1994)
125. CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation. (PubMed id 7954828)⁹ Hake L.E. and Richter J.D. (1994)
126. Electrostatic interactions modulate the RNA-binding a nd transactivation specificities of the human immunodeficiency virus and simian immunodeficiency virus Tat proteins. (PubMed id 8434019)⁹ Tao J. and Frankel A.D. (1993)
127. Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs. (PubMed id 8497264)⁹ Levine T.D....Keene J.D. (1993)
128. Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif. (PubMed id 1715576)⁹ Zapp M.L....Green M.R. (1991)
129. HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence. (PubMed id 2406030)⁹ Malim M.H....Cullen B.R. (1990)
130. The Neuronal Splicing Factor Nova Co-Localizes with T arget RNAs in the Dendrite. (PubMed id 20407637)⁹ Racca C....Darnell R.B. (2010)
131. Northwestern profiling of potential translation-regul atory proteins in human breast epithelial cells and malignant breast tissues: e vidence for pathological activation of the IGF1R IRES. (PubMed id 20233590)⁹ Blume S.W....Meng Z. (2010)
132. The epithelial splicing factors ESRP1 and ESRP2 posit ively and negatively regulate diverse types of alternative splicing events. (PubMed id 19829082)⁹ Warzecha C.C....Carstens R.P. (2009)
133. Derivation of male germ cell-like lineage from human fetal bone marrow stem cells. (PubMed id 19573297)⁹ Hua J....Sidhu K.S. (2009)
134. Role of RNA chaperones in virus replication. (PubMed id 18675859)⁹ ZA_A+iga S....Enjuanes L. (2009)
135. Gene polymorphisms/mutations relevant to abnormal spermatogenesis. (PubMed id 18413059)⁹ Nuti F. and Krausz C. (2008)
136. A Caenorhabditis elegans PUF protein family with distinct RNA binding specificity. (PubMed id 18579869)⁹ Stumpf C.R....Wickens M. (2008)
137. Premature ovarian failure (POF) syndrome: towards the molecular clinical analysis of its genetic complexity. (PubMed id 16719785)⁹ Fassnacht W....Vogt P.H. (2006)
138. In vivo post-transcriptional regulation of GAP-43 mRNA by overexpression of the RNA-binding protein HuD. (PubMed id 16405504)⁹ Bolognani F....Perrone-Bizzozero N.I. (2006)
139. Regulation of gene expression in post-meiotic male germ cells: CREM-signalling pathways and male fertility. (PubMed id 16825108)⁹ Hogeveen K.N. and Sassone-Corsi P. (2006)
140. CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA. (PubMed id 17024188)⁹ Huang Y.S....Richter J.D. (2006)
141. A putative nuclear function for mammalian Staufen. (PubMed id 15896738)⁹ Kiebler M.A....Macchi P. (2005)
142. Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. (PubMed id 15744350)⁹ Prima V.... Hunger S.P. (2005)
143. Role of the DAZ genes in male fertility. (PubMed id 15705297)⁹ Reynolds N. and Cooke H.J. (2005)
144. Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate. (PubMed id 12832361)⁹ Fisher J.S....Sharpe R.M. (2003)
145. Idiopathic cases of male infertility from a region in India show low incidence of Y-chromosome microdeletion. (PubMed id 14517364)⁹ Ambasudhan R....Raman R. (2003)
146. Role of HuD and other RNA-binding proteins in neural development and plasticity. (PubMed id 11948657)⁹ Perrone-Bizzozero N. and Bolognani F. (2002)
147. cis-acting regulatory elements in the GAP-43 mRNA 3'-untranslated region can function in trans to suppress endogenous GAP-43 gene expression. (PubMed id 10036307)⁹ Neve R.L....Perrone-Bizzozero N.I. (1999)
148. Biphasic subcellular localization of the DAZL-related protein boule in Drosophila spermatogenesis. (PubMed id 9882490)⁹ Cheng M.H....Wasserman S.A. (1998)
149. Neuron-specific hel-N1 and HuD as novel molecular markers of neuroblastoma: a correlation of HuD messenger RNA levels with favorable prognostic features. (PubMed id 9815574)⁹ Ball N.S. and King P.H. (1997)
150. Genomic organization and mutation analysis of Hel-N1 in lung cancers with chromosome 9p21 deletions. (PubMed id 9393760)⁹ Cairns P....Sidransky D. (1997)
151. Zebrafish elav/HuC homologue as a very early neuronal marker. (PubMed id 8904795)⁹ Kim C.H....Miki N. (1996)
152. Appearance of neurons in the developing chick gut. (PubMed id 8589443)⁹ Fairman C.L....Epstein M.L. (1995)
153. RNA recognition by the human immunodeficiency virus Tat and Rev proteins. (PubMed id 8212135)⁹ Gait M.J. and Karn J. (1993)

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