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DAZL Gene

protein-coding   GIFtS: 61
GCID: GC03M016603

Deleted In Azoospermia-Like


(Previous symbol: DAZLA)
  See DAZL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deleted In Azoospermia-Like1 2     SPGY-like-autosomal2 3
DAZLA1 2 3     DAZ Homolog2 3
DAZH2 3 5     DAZ-Like Autosomal2 3
SPGYLA2 3 5     Germline Specific RNA Binding Protein2
Deleted In Azoospermia-Like 12 3     Spermatogenesis Gene On The Y-Like Autosomal2
DAZL12 3     

External Ids:    HGNC: 26851   Entrez Gene: 16182   Ensembl: ENSG000000923457   OMIM: 6014865   UniProtKB: Q929043   

Export aliases for DAZL gene to outside databases

Previous GC identifer: GC03M016557


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAZL Gene:
The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal
and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and
cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is
localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in
spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave
rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic
failure and infertility in males. Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jun 2010)

GeneCards Summary for DAZL Gene:
DAZL (deleted in azoospermia-like) is a protein-coding gene. Diseases associated with DAZL include azoospermia, and spermatogenic failure. GO annotations related to this gene include RNA binding and translation activator activity. An important paralog of this gene is DAZ1.

UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
Function: RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central
role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and
thereby regulating the translation of key transcripts (By similarity)

Gene Wiki entry for DAZL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAZL gene promoter:
         Max1   Pbx1a   Pax-6   MEF-2A   AREB6   FOXJ2 (long isoform)   aMEF-2   FOXJ2   RSRFC4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAZL promoter sequence
   Search Chromatin IP Primers for DAZL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAZL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24

DAZL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAZL gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M016603:  view genomic region     (about GC identifiers)

Start:
16,628,299 bp from pter      End:
16,711,813 bp from pter
Size:
83,515 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904 (See protein sequence)
Recommended Name: Deleted in azoospermia-like  
Size: 295 amino acids; 33178 Da
Subunit: Homodimer and heterodimer. Multiple DAZL RRMs can bind to a single RNA containing multiple GUU triplets
(By similarity). Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2
Secondary accessions: O15396 Q5HYB4 Q92909
Alternative splicing: 2 isoforms:  Q92904-1   Q92904-2   

Explore the universe of human proteins at neXtProt for DAZL: NX_Q92904

Explore proteomics data for DAZL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DAZL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177740.1  NP_001342.2  

    ENSEMBL proteins: 
     ENSP00000250863   ENSP00000382373   ENSP00000398109  

    DAZL Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DAZL

     
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    antibodies-online proteins for DAZL (4 products) 

     
    antibodies-online peptides for DAZL

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    antibodies-online kits for DAZL (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q92904

    ProtoNet protein and cluster: Q92904

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
    Domain: The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2
    Similarity: Belongs to the RRM DAZ family
    Similarity: Contains 1 DAZ-like domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with DAZL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAZL_HUMAN, Q92904
    Function: RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central
    role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and
    thereby regulating the translation of key transcripts (By similarity)

         Genatlas biochemistry entry for DAZL:
    deleted in azoospermia,autosomal-like,homolog of the mouse Dazla gene and the Drosophila boule (SPGY like
    autosomal),expressed only in male gonad

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS8968755
    GO:0003730mRNA 3'-UTR binding IEA--
    GO:0005515protein binding IPI16001084
         
    Find genes that share ontologies with DAZL           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DAZL:
     Increased G2M DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dazl):
     endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with DAZL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dazltm1Hjc for DAZL

       genOway: Develop your customized and physiologically relevant rodent model for DAZL

    miRNA
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    miRTarBase miRNAs that target DAZL:
    hsa-mir-335-5p (MIRT016720)

    Block miRNA regulation of human, mouse, rat DAZL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAZL (see all 22):
    hsa-miR-3938 hsa-miR-607 hsa-miR-3664-5p hsa-miR-4328 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidDAZL 3' UTR sequence
    Inhib. RNA
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    eBioscience FlowRNA Probe Sets ( VA1-14276) for DAZL 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DAZL_HUMAN, Q92904: Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (By
    similarity). Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization
    from then onward (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005844polysome IEA--

    Find genes that share ontologies with DAZL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAZL About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control
    2Ovarian Infertility Genes
    Ovarian Infertility Genes


    Find genes that share SuperPaths with DAZL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DAZL
        Translational Control

    1 BioSystems Pathway for DAZL
        Ovarian Infertility Genes



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DAZL
    Interactions:

        GeneGlobe Interaction Network for DAZL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for DAZL (Q929043 ENSP000003823734) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAZ1Q9NQZ33, ENSP000003845734I2D: score=3 STRING: ENSP00000384573
    DAZAP1Q96EP53, ENSP000002330784I2D: score=2 STRING: ENSP00000233078
    DCTN1Q142033, ENSP000003547914I2D: score=1 STRING: ENSP00000354791
    DCTN2Q135613, ENSP000004089104I2D: score=1 STRING: ENSP00000408910
    DYNC1I1O145763, ENSP000003201304I2D: score=1 STRING: ENSP00000320130
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007281germ cell development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0045836positive regulation of meiosis IEA--
    GO:0045948positive regulation of translational initiation IDA16001084

    Find genes that share ontologies with DAZL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAZL

    2 Novoseek inferred chemical compound relationships for DAZL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vas-a 55.3 14 18088417 (8), 16228988 (2), 19573297 (1), 19602557 (1) (see all 5)
    adenylate 0.705 4 10819768 (1)



    Find genes that share compounds with DAZL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DAZL gene (2 alternative transcripts): 
    NM_001190811.1  NM_001351.3  

    Unigene Cluster for DAZL:

    Deleted in azoospermia-like
    Hs.131179  [show with all ESTs]
    Unigene Representative Sequence: NM_001190811
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250863(uc003cba.3) ENST00000399444(uc003cbb.3) ENST00000454457

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DAZL (see all 22):
    hsa-miR-3938 hsa-miR-607 hsa-miR-3664-5p hsa-miR-4328 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidDAZL 3' UTR sequence
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    Additional mRNA sequence: 

    AK303026.1 AK310341.1 BC027595.2 BX648638.1 U65918.1 U66078.1 U66726.2 

    2 DOTS entries:

    DT.310516  DT.97804595 

    Selected AceView cDNA sequences (see all 52):

    NM_001351 AL705991 BX648638 BI464024 BI461267 BG723910 BG718804 BG210841 
    BX088864 BG771817 BG207704 U66078 CD300236 BF980336 BI464057 BI829533 
    BU569412 BI459106 BI460958 AL044707 BU853969 AA774538 CD557344 U66726 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAZL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAAATA
    DAZL Expression
    About this image


    DAZL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Gonad (Reproductive System)    fully expand to see all 9 entries
             Primordial Germ Cells Primitive Gonad
             Primordial germ-like cells
     
     Germ Cells (Reproductive System)    fully expand to see all 5 entries
             Primordial germ-like cells
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             XX Germ Cells Ovigerous Cord
             Ovarian tissue-dissociated cells (human)
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             ES-J1
    DAZL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAZL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131179

    UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
    Tissue specificity: Testis specific

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DAZL gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dazl5 deleted in azoospermia-like   --   17 (25.86 cM) 50279394 
    chicken
    (Gallus gallus)
    Aves DAZL6
    Gallus gallus deleted in azoospermia-like (DAZL), ...
    65(a)
    1 → many
    2(34939869-35003900)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    65(a)
    1 → many
    6(34873464-34894381)
    African clawed frog
    (Xenopus laevis)
    Amphibia dazl2 DAZ-like protein 77.98(n)    AF017778.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dazl2 daz-like gene 73.65(n)   58039  AB018191.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bol6
    boule
    25(a)
    1 → many
    3L(9091208-9123452)
    worm
    (Caenorhabditis elegans)
    Secernentea daz-16
    Protein DAZ-1 (daz-1) mRNA, complete cds
    15(a)
    1 → many
    II(5456305-5458616) WBGene00000935


    ENSEMBL Gene Tree for DAZL (if available)
    TreeFam Gene Tree for DAZL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAZL gene
    DAZ12  DAZ32  DAZ42  DAZ22  BOLL2  
    8 SIMAP similar genes for DAZL using alignment to 3 protein entries:     DAZL_HUMAN (see all proteins):
    DAZ2    DAZ3    DAZ4    DAZ1    BOLL    RBMY1A1
    RBFOX2    HNRNPA2B1

    Find genes that share paralogs with DAZL           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for DAZL
    PGOHUM00000233822 PGOHUM00000233854 PGOHUM00000234035 PGOHUM00000234068


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAZL (see all 565)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18085181,2
    C,F,A,H--16563813(+) ACTAAA/CTGATG 2 -- int1102Minor allele frequency- C:0.31NS NA EA PA EU CA WA 6430
    rs610935751,2
    --16563879(+) ATTGGG/TAGTAC 2 -- int10--------
    rs1482689151,2
    --16563928(+) TTTTTG/TATTGC 2 -- int10--------
    rs751483541,2
    F--16563938(+) CATCCA/GTAAGA 2 -- int11Minor allele frequency- G:0.02WA 118
    rs170424401,2
    C,F--16563984(+) GCAACC/TGCAAT 2 -- int13Minor allele frequency- T:0.01NA 138
    rs1140936681,2
    F--16564005(+) AAAAGG/TTCTAG 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1911524701,2
    --16564017(+) GATTAA/GGCCCA 2 -- int10--------
    rs105104531,2
    C,F,H--16564027(+) AAAGCG/ATACAG 2 -- int1104Minor allele frequency- A:0.09NS NA EA PA EU CA WA CSA 6304
    rs1503824991,2
    C--16564095(+) AGTCAG/TATGTG 2 -- int10--------
    rs23473121,2
    C,A,H--16564318(+) AAAAAG/CTTTAT 2 -- ut3111Minor allele frequency- C:0.25EA WA NA CSA 1843

    HapMap Linkage Disequilibrium report for DAZL (16628299 - 16711813 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DAZL (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv822025CNV Loss20364138
    nsv822019CNV Loss20364138
    dgv796n67CNV Loss20364138
    esv22139CNV Loss19812545
    nsv822018CNV Loss20364138
    nsv876586CNV Loss21882294
    nsv822021CNV Loss20364138
    nsv509814CNV Loss20534489
    nsv822024CNV Loss20364138
    dgv798n67CNV Loss20364138

    Human Gene Mutation Database (HGMD): DAZL
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DAZL
    DNA2.0 Custom Variant and Variant Library Synthesis for DAZL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 601486    OMIM disorders: --

    6 diseases for DAZL:    
    About MalaCards
    azoospermia    spermatogenic failure    paraneoplastic syndromes    paraneoplastic neurologic disorders
    seminoma    infertility

    2 diseases from the University of Copenhagen DISEASES database for DAZL:
    Male infertility     Infertility

    Find genes that share disorders with DAZL           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DAZL gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azoospermia 86.9 37 9783841 (2), 9294855 (2), 16123080 (2), 10527983 (1) (see all 26)
    infertility male 74.1 17 9294855 (3), 16573709 (2), 17918711 (2), 8968756 (2) (see all 9)
    paraneoplastic encephalomyelitis 70.6 1 8982120 (1)
    oligozoospermia 70.5 5 9294855 (2), 16573709 (1), 16123080 (1)
    infertility 52.4 5 20300286 (1), 11604102 (1), 17918711 (1), 14965334 (1)
    sterility male 51.7 3 9143498 (2), 16844779 (1)
    ovarian failure premature 50.8 2 10527983 (1)
    chromosome deletion 38.4 1 10601091 (1)
    paraneoplastic syndromes 27.4 1 10735272 (1)
    seminoma 18.4 7 11956819 (3), 16228988 (2)

    Genetic Association Database (GAD): DAZL
    Human Genome Epidemiology (HuGE) Navigator: DAZL (12 documents)

    Export disorders for DAZL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DAZL gene, integrated from 10 sources (see all 158) (see top 10):
    (articles sorted by number of sources associating them with DAZL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of a single-nucleotide polymorphism of the deleted-in- azoospermia-like gene with susceptibility to spermatogenic failure. (PubMed id 12414900)1, 2, 4 Teng Y.-N.... Kuo P.-L. (J. Clin. Endocrinol. Metab. 2002)
    2. The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. (PubMed id 8896558)1, 2, 3 Saxena R....Page D.C. (Nat. Genet. 1996)
    3. A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad. (PubMed id 8968755)1, 2, 9 Shan Z.... Vogt P.H. (Hum. Mol. Genet. 1996)
    4. Phenotypic expression of partial AZFc deletions is independent of the variations in DAZL and BOULE in a Han population. (PubMed id 19342699)1, 4, 9 Chen P....Yang Y. (J. Androl. 2010)
    5. A putative human male infertility gene DAZLA: genomic structure and methylation status. (PubMed id 9294855)1, 2, 9 Chai N.-N.... Yen P.H. (Mol. Hum. Reprod. 1997)
    6. The human autosomal gene DAZLA: testis specificity and a candidate for male infertility. (PubMed id 8968756)1, 2, 9 Yen P.H.... Salido E.C. (Hum. Mol. Genet. 1996)
    7. A to G transitions at 260, 386 and 437 in DAZL gene are not associated with spermatogenic failure in Indian population. (PubMed id 16573709)1, 4, 9 Thangaraj K....Singh L. (Int. J. Androl. 2006)
    8. Association of DAZL haplotypes with spermatogenic failure in infertile men. (PubMed id 16730721)1, 4, 9 Teng Y.N....Kuo P.L. (Fertil. Steril. 2006)
    9. Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PubMed id 10857750)1, 2, 9 Tsui S.... Yen P.H. (Genomics 2000)
    10. [Autosomal DAZL single nucleotide polymorphisms not associated with male infertility in northeast China]. (PubMed id 17918711)1, 4, 9 Wen X.H....Wu W. (Zhonghua Nan Ke Xue 2007)
    11. Survey of the two polymorphisms in DAZL, an autosomal candidate for the azoospermic factor, in Japanese infertile men and implications for male infertility. (PubMed id 16123080)1, 4, 9 Yang X.J....Nakahori Y. (Mol. Hum. Reprod. 2005)
    12. A386G polymorphism of the DAZL gene is not associated with idiopathic male infertility in North India. (PubMed id 19881148)1, 4, 9 Singh K. and Raman R. (J Hum Reprod Sci 2009)
    13. A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. (PubMed id 11390979)1, 2, 9 Xu E.Y.... Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    14. No association of the A260G and A386G DAZL single nucleotide polymorphisms with male infertility in a Caucasian population. (PubMed id 15520024)1, 4, 9 Tschanter P....Gromoll J. (Hum. Reprod. 2004)
    15. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)1, 2, 9 Moore F.L.... Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    16. Gene polymorphisms and male infertility--a meta-analysis and literature review. (PubMed id 18062861)1, 4 TA1ttelmann F....Simoni M. (Reprod. Biomed. Online 2007)
    17. DAZL polymorphisms and susceptibility to spermatogenic failure: an example of remarkable ethnic differences. (PubMed id 15595957)1, 4 Becherini L....Krausz C. (Int. J. Androl. 2004)
    18. Lack of the T54A polymorphism of the DAZL gene in infertile Italian patients. (PubMed id 15220464)1, 4 Bartoloni L....Foresta C. (Mol. Hum. Reprod. 2004)
    19. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    20. Gene sequence, localization, and evolutionary conservation of DAZLA, a candidate male sterility gene. (PubMed id 9143498)1, 9 Seboun E....Algonik A. (Genomics 1997)
    21. DAZL expression in human oocytes, preimplantation embryos and embryonic stem cells. (PubMed id 15879466)1, 9 Cauffman G....Van Steirteghem A. (Mol. Hum. Reprod. 2005)
    22. Association of the mouse infertility factor DAZL1 with actively translating polyribosomes. (PubMed id 10819768)1, 9 Tsui S....Yen P.H. (Biol. Reprod. 2000)
    23. Conserved and divergent patterns of expression of DAZL, VASA and OCT4 in the germ cells of the human fetal ovary and testis. (PubMed id 18088417)1, 9 Anderson R.A....Saunders P.T. (BMC Dev. Biol. 2007)
    24. Novel missense mutations of the Deleted-in-AZoospermia-Like (DAZL) gene in infertile women and men. (PubMed id 16884537)1, 9 Tung J.Y....Reijo-Pera R.A. (amp 2006)
    25. Expression of DAZL protein in the human corpus luteum. (PubMed id 12029071)1, 9 Pan H.A....Kuo P.L. (Mol. Hum. Reprod. 2002)
    26. Localization of a specific germ cell marker, DAZL1, in testicular germ cell neoplasias. (PubMed id 11956819)1, 9 Lifschitz-Mercer B....Maymon B.B. (Virchows Arch. 2002)
    27. The DAZL1 gene is expressed in human male and female embryonic gonads before meiosis. (PubMed id 10775651)1, 9 Brekhman V....Seligman J. (Mol. Hum. Reprod. 2000)
    28. Human DAZL1 encodes a candidate fertility factor in women that localizes to the prenatal and postnatal germ cells. (PubMed id 10527983)1, 9 Dorfman D.M....Reijo Pera R.A. (Hum. Reprod. 1999)
    29. Dynamic subcellular distribution of the DAZL protein is confined to primate male germ cells. (PubMed id 10819456)1, 9 Ruggiu M....Cooke H.J. (J. Androl. 2000)
    30. Follicle-stimulating hormone receptor and DAZL gene polymorphisms do not affect the age of menopause. (PubMed id 18178196)1, 9 Zerbetto I....Petraglia F. (Fertil. Steril. 2008)
    31. Presence of DAZL transcript and protein in mature human spermatozoa. (PubMed id 11872225)1, 9 Lin Y.M....Kuo P.L. (Fertil. Steril. 2002)
    32. Expression patterns and transcript concentrations of the autosomal DAZL gene in testes of azoospermic men. (PubMed id 11675467)1, 9 Lin Y.M....Kuo P.L. (Mol. Hum. Reprod. 2001)
    33. The mouse Dazla gene encodes a cytoplasmic protein essential for gametogenesis. (PubMed id 9288969)1, 9 Ruggiu M....Cooke H.J. (Nature 1997)
    34. Expression profiles of the DAZ gene family in human testis with and without spermatogenic failure. (PubMed id 15066460)1, 9 Kuo P.L....Hsu C.C. (Fertil. Steril. 2004)
    35. The expression of DAZL1 in the ovary of the human female fetus. (PubMed id 10689024)1, 9 Tsai M.Y....Lu Y.J. (Fertil. Steril. 2000)
    36. Variants in Deleted in AZoospermia-Like (DAZL) are correlated with reproductive parameters in men and women. (PubMed id 16328470)1, 9 Tung J.Y....Pera R.A. (Hum. Genet. 2006)
    37. The DAZL family proteins are PABP-binding proteins that regulate translation in germ cells. (PubMed id 16001084)1, 9 Collier B....Gray N.K. (EMBO J. 2005)
    38. In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein. (PubMed id 10903443)1, 9 Ruggiu M. and Cooke H.J. (Gene 2000)
    39. Existence of human DAZLA protein in the cytoplasm of human oocytes. (PubMed id 10340994)1, 9 Nishi S....Fujimoto S. (Mol. Hum. Reprod. 1999)
    40. Human DAZL, DAZ and BOULE genes modulate primordial germ-cell and haploid gamete formation. (PubMed id 19865085)1, 9 Kee K.... Reijo Pera R.A. (Nature 2009)
    41. Deleted in Azoospermia-Like (DAZL) gene-expressing cells in human amniotic fluid: a new source for germ cells research? (PubMed id 18023443)1, 9 Stefanidis K....Antsaklis A. (Fertil. Steril. 2008)
    42. Partial rescue of the Dazl knockout mouse by the human DAZL gene. (PubMed id 12200456)1, 9 Vogel T....Cooke H.J. (Mol. Hum. Reprod. 2002)
    43. DAZLA: an important candidate gene in male subfertility? (PubMed id 11499325)1, 9 Van Golde R.J....Hoefsloot L.H. (J. Assist. Reprod. Genet. 2001)
    44. DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice. (PubMed id 11058556)1, 9 Reijo R.A.... Page D.C. (Biol. Reprod. 2000)
    45. A human DAZ transgene confers partial rescue of the mouse Dazl null phenotype. (PubMed id 10393944)1, 9 Slee R....Cooke H.J. (Proc. Natl. Acad. Sci. U.S.A. 1999)
    46. [DAZL gene polymorphisms and astheno-teratozoospermia]. (PubMed id 23678708)1 Ye L.W....Mao X.M. (Zhonghua Nan Ke Xue 2013)
    47. Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14. (PubMed id 23666240)1 Ruark E....Turnbull C. (Nat. Genet. 2013)
    48. Nodal, Nanog, DAZL and SMAD gene expression in human amniotic fluid stem cells. (PubMed id 24459810)1 Stefanidis K....Antsaklis A. (J Stem Cells 2013)
    49. A single-nucleotide polymorphism of the DAZL gene promoter confers susceptibility to spermatogenic failure in the Taiwanese Han. (PubMed id 22752612)1 Teng Y.N....Kuo P.L. (Hum. Reprod. 2012)
    50. Divergent RNA-binding proteins, DAZL and VASA, induce meiotic progression in human germ cells derived in vitro. (PubMed id 22162380)1 Medrano J.V....Reijo Pera R.A. (Stem Cells 2012)
    51. DAZL 260A &gt; G and MTHFR 677C &gt; T variants in sperm DNA of infertile Indian men. (PubMed id 22329245)1 Kumar K....Dada R. (amp 2011)
    52. Kinked beta-strands mediate high-affinity recognition of mRNA targets by the germ-cell regulator DAZL. (PubMed id 22021443)2 Jenkins H.T.... Edwards T.A. (Proc. Natl. Acad. Sci. U.S.A. 2011)
    53. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    54. Incorrect DNA methylation of the DAZL promoter CpG island associates with defective human sperm. (PubMed id 20685756)1 Navarro-Costa P....Plancha C.E. (Hum. Reprod. 2010)
    55. The dazzle in germ cell differentiation. (PubMed id 20008336)1 Kerr C.L. and Cheng L. (J Mol Cell Biol 2010)
    56. Quantitative trait analysis suggests human DAZL may be involved in regulating sperm counts and motility. (PubMed id 20462796)1 Hsu C.C....Kuo P.L. (Reprod. Biomed. Online 2010)
    57. A method for isolating pluripotent/multipotent stem cells from blood by using the pluripotent and germ-line DAZL gene as a marker. (PubMed id 19327014)1 Seligman J....Fabian I. (Stem Cells Dev. 2009)
    58. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    59. A germline-specific class of small RNAs binds mammalian Piwi proteins. (PubMed id 16751776)1 Girard A....Carmell M.A. (Nature 2006)
    60. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    61. The DNA sequence, annotation and analysis of human chromosome 3. (PubMed id 16641997)2 Muzny D.M....Gibbs R.A. (Nature 2006)
    62. Identification and characterization of RNA sequences to which human PUMILIO-2 (PUM2) and deleted in Azoospermia-like (DAZL) bind. (PubMed id 15607425)1 Fox M.... Reijo Pera R.A. (Genomics 2005)
    63. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    64. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    65. Evolution of the DAZ gene family suggests that Y-linked DAZ plays little, or a limited, role in spermatogenesis but underlines a recent African origin for human populations. (PubMed id 9700189)1 Agulnik A.I....Bishop C.E. (Hum. Mol. Genet. 1998)
    66. (PubMed id 16051679)4 
    67. Evolutionary comparison of the reproductive genes, DAZL and BOULE, in primates with and without DAZ. (PubMed id 16425031)9 Tung J.Y....Gromoll J. (Dev. Genes Evol. 2006)
    68. Expression of DAZ (deleted in azoospermia), DAZL1 (DAZ-like) and protamine-2 in testis and its application for diagnosis of spermatogenesis in non-obstructive azoospermia. (PubMed id 9783841)9 Lee J.H....Yoon H.S. (Mol. Hum. Reprod. 1998)
    69. Porcine DAZL messenger RNA: its expression and regulation during oocyte maturation. (PubMed id 19540306)9 Liu J....Li J. (Mol. Cell. Endocrinol. 2009)
    70. The Dazh gene is expressed in male and female embryonic gonads before germ cell sex differentiation. (PubMed id 9588208)9 Seligman J. and Page D.C. (Biochem. Biophys. Res. Commun. 1998)
    71. Genomic structure and transcript variants of the bovine DAZL gene. (PubMed id 17268180)9 Liu W.S....Ponce de LeA^n F.A. (Cytogenet. Genome Res. 2007)
    72. Conservation of the deleted-in-azoospermia-like-1 (DAZL1) gene structure in old world monkeys points to a homologous function of DAZL1 in this primate class. (PubMed id 11079458)9 Grossmann B....Vogt P.H. (J. Endocrinol. Invest. 2000)
    73. CDC25 protein expression and interaction with DAZL in human corpus luteum. (PubMed id 19006796)9 Pan H.A....Kuo P.L. (Fertil. Steril. 2009)
    74. A386G transition in DAZL gene is not associated with spermatogenic failure in Tamil Nadu, South India. (PubMed id 20300286)9 Poongothai J....Manonayaki S. (Indian J Hum Genet 2008)
    75. DAZL binds to the transcripts of several Tssk genes in germ cells. (PubMed id 18452650)9 Zeng M....Ma Y. (BMB Rep 2008)
    76. Cloning and expression of medaka dazl during embryogenesis and gametogenesis. (PubMed id 16979959)9 Xu H....Hong Y. (Gene Expr. Patterns 2007)
    77. Mice with Y chromosome deletion and reduced Rbm genes on a heterozygous Dazl1 null background mimic a human azoospermic factor phenotype. (PubMed id 10601091)9 Vogel T....Cooke H.J. (Hum. Reprod. 1999)
    78. Boule is present in fish and bisexually expressed in adult and embryonic germ cells of medaka. (PubMed id 19564913)9 Xu H....Hong Y. (PLoS ONE 2009)
    79. cynDAZLA: a cynomolgus monkey homologue of the human autosomal DAZ gene. (PubMed id 9239736)9 Carani C....Nieschlag E. (Mol. Hum. Reprod. 1997)
    80. Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL. (PubMed id 11604102)9 Dai T....Yen P.H. (BMC Genomics 2001)
    81. The Old World monkey DAZ (Deleted in AZoospermia) gene yields insights into the evolution of the DAZ gene cluster on the human Y chromosome. (PubMed id 10484770)9 Gromoll J....Nieschlag E. (Hum. Mol. Genet. 1999)
    82. Mouse autosomal homolog of DAZ, a candidate male sterility gene in humans, is expressed in male germ cells before and after puberty. (PubMed id 8661148)9 Reijo R....Page D.C. (Genomics 1996)
    83. Isolation of a sequence-specific RNA binding protein, polypyrimidine tract binding protein, using RNA affinity chromatography. (PubMed id 18982280)9 Sharma S. (Methods Mol. Biol. 2008)
    84. [Analysis of an AZFc deletion family with natural transmission]. (PubMed id 16970164)9 Xia X.Y....Wang X.L. (Zhonghua Nan Ke Xue 2006)
    85. Case report: natural transmission of an AZFc Y-chromosomal microdeletion from father to his sons. (PubMed id 15016778)9 KA1hnert B....Nieschlag E. (Hum. Reprod. 2004)
    86. Cell-specific RNA-binding proteins in human disease. (PubMed id 12837581)9 Musunuru K. (Trends Cardiovasc. Med. 2003)
    87. The onconeural antigen Nova-1 is a neuron-specific RNA-binding protein, the activity of which is inhibited by paraneoplastic antibodies. (PubMed id 8558240)9 Buckanovich R.J....Darnell R.B. (J. Neurosci. 1996)
    88. An RNA chaperone activity of non-specific RNA binding proteins in hammerhead ribozyme catalysis. (PubMed id 8026476)9 Herschlag D....Karpel R.L. (EMBO J. 1994)
    89. The lentivirus regulatory proteins REV and REX are site specific RNA binding proteins. (PubMed id 1666813)9 Farrington G.K....Rusche J. (Adv. Exp. Med. Biol. 1991)
    90. Prostaglandin E2 as a regulator of germ cells during ovarian development. (PubMed id 19602557)9 Bayne R.A....Anderson R.A. (J. Clin. Endocrinol. Metab. 2009)
    91. Molecular characterization and SNPs analysis of the porcine Deleted in AZoospermia Like (pDAZL) gene. (PubMed id 18620821)9 Zhang Y.H....Li F.E. (Anim. Reprod. Sci. 2009)
    92. Transposition of two amino acids changes a promiscuous RNA binding protein into a sequence-specific RNA binding protein. (PubMed id 18000034)9 Garrey S.M....Berglund J.A. (RNA 2008)
    93. Expression of pluripotent stem cell markers in the human fetal testis. (PubMed id 18024420)9 Kerr C.L....Gearhart J.D. (Stem Cells 2008)
    94. Evolution of the DAZ gene and the AZFc region on primate Y chromosomes. (PubMed id 18366765)9 Yu Y.H....Yen P.H. (BMC Evol. Biol. 2008)
    95. Global analysis of the medulloblastoma epigenome identifies disease-subgroup-specific inactivation of COL1A2. (PubMed id 18664619)9 Anderton J.A....Clifford S.C. (Neuro-oncology 2008)
    96. Functional and mechanistic insights from genome-wide studies of splicing regulation in the brain. (PubMed id 18380345)9 Ule J. and Darnell R.B. (Adv. Exp. Med. Biol. 2007)
    97. RINGO/cdk1 and CPEB mediate poly(A) tail stabilization and translational regulation by ePAB. (PubMed id 17938241)9 Kim J.H. and Richter J.D. (amp 2007)
    98. Regulated Pumilio-2 binding controls RINGO/Spy mRNA translation and CPEB activation. (PubMed id 16418484)9 Padmanabhan K. and Richter J.D. (amp 2006)
    99. Evaluation of DAZ microdeletions in 34 infertile men. (PubMed id 16574598)9 Abdelmoula N.B....Rebai T. (Arch. Androl. 2006)
    100. Heritable and stable gene knockdown in rats. (PubMed id 16844779)9 Dann C.T....Garbers D.L. (Proc. Natl. Acad. Sci. U.S.A. 2006)
    101. CPEB controls oocyte growth and follicle development in the mouse. (PubMed id 17050619)9 Racki W.J. and Richter J.D. (Development 2006)
    102. Post-transcriptional control in the male germ line. (PubMed id 15705295)9 Ehrmann I. and Elliott D.J. (Reprod. Biomed. Online 2005)
    103. Human embryonic stem cell genes OCT4, NANOG, STELLAR, and GDF3 are expressed in both seminoma and breast carcinoma. (PubMed id 16228988)9 Ezeh U.I....Clark A.T. (Cancer 2005)
    104. The Drosophila fragile X protein functions as a negative regulator in the orb autoregulatory pathway. (PubMed id 15737929)9 Costa A....Jongens T.A. (Dev. Cell 2005)
    105. Interaction of the conserved meiotic regulators, BOULE (BOL) and PUMILIO-2 (PUM2). (PubMed id 15806553)9 Urano J....Reijo Pera R.A. (Mol. Reprod. Dev. 2005)
    106. Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries. (PubMed id 16209998)9 Pan H.A....Kuo P.L. (Fertil. Steril. 2005)
    107. Common molecular pathways mediate long-term potentiation of synaptic excitation and slow synaptic inhibition. (PubMed id 16213216)9 Huang C.S....Jan L.Y. (Cell 2005)
    108. Spatio-temporal expression of a DAZ-like gene in the Japanese newt Cynops pyrrhogaster that has no germ plasm. (PubMed id 15490230)9 Tamori Y....Wakahara M. (Dev. Genes Evol. 2004)
    109. Putative biological functions of the DAZ family. (PubMed id 15139965)9 Yen P.H. (Int. J. Androl. 2004)
    110. Identification of a novel gene, DZIP (DAZ-interacting protein), that encodes a protein that interacts with DAZ (deleted in azoospermia) and is expressed in embryonic stem cells and germ cells. (PubMed id 15081113)9 Moore F.L.... Reijo-Pera R.A. (Genomics 2004)
    111. Molecular genetics of human male infertility: from genes to new therapeutic perspectives. (PubMed id 14965334)9 Vogt P.H. (Curr. Pharm. Des. 2004)
    112. Nova regulates GABA(A) receptor gamma2 alternative splicing via a distal downstream UCAU-rich intronic splicing enhancer. (PubMed id 12808107)9 Dredge B.K. and Darnell R.B. (Mol. Cell. Biol. 2003)
    113. Interactions of heterogeneous nuclear ribonucleoprotein D-like protein JKTBP and its domains with high-affinity binding sites. (PubMed id 12406575)9 Kamei D. and Yamada M. (Gene 2002)
    114. Single-nucleotide variant in multiple copies of a deleted in azoospermia (DAZ) sequence - a human Y chromosome quantitative polymorphism. (PubMed id 11901266)9 Szmulewicz M.N....Herrera R.J. (Hum. Hered. 2002)
    115. A novel, rapid, and accurate method for detecting microdeletion involving the DAZ gene in infertile men. (PubMed id 10685522)9 Lucas H....Bienvenu T. (Fertil. Steril. 2000)
    116. A critical role for Xdazl, a germ plasm-localized RNA, in the differentiation of primordial germ cells in Xenopus. (PubMed id 10631166)9 Houston D.W. and King M.L. (Development 2000)
    117. HuD, a neuronal-specific RNA-binding protein, is a putative regulator of N-myc pre-mRNA processing/stability in malignant human neuroblasts. (PubMed id 10348344)9 Lazarova D.L....Ross R.A. (Oncogene 1999)
    118. Nucleolin: a multifunctional major nucleolar phosphoprotein. (PubMed id 9918513)9 Tuteja R. and Tuteja N. (Crit. Rev. Biochem. Mol. Biol. 1998)
    119. A Xenopus DAZ-like gene encodes an RNA component of germ plasm and is a functional homologue of Drosophila boule. (PubMed id 9486791)9 Houston D.W....King M.L. (Development 1998)
    120. ANOVA, a putative astrocytic RNA binding protein gene that maps to chromosome 19q13.3. (PubMed id 10735272)9 Ueki K.... Louis D.N. (Neurogenetics 1997)
    121. HuD, a neuronal-specific RNA-binding protein, is a potential regulator of MYCN expression in human neuroblastoma cells. (PubMed id 9516855)9 Ross R.A....Biedler J.L. (Eur. J. Cancer 1997)
    122. Mouse chromosomal locations of nine genes encoding homologs of human paraneoplastic neurologic disorder antigens. (PubMed id 9344654)9 Fletcher C.F....Darnell R.B. (Genomics 1997)
    123. Expression of Hel-N1 and Hel-N2 in small-cell lung carcinoma. (PubMed id 8619556)9 King P.H. and Dropcho E.J. (Ann. Neurol. 1996)
    124. Nucleolin is a sequence-specific RNA-binding protein: characterization of targets on pre-ribosomal RNA. (PubMed id 8676391)9 Ghisolfi-Nieto L....Bouvet P. (J. Mol. Biol. 1996)
    125. The HuD paraneoplastic protein shares immunogenic regions between PEM/PSN patients and several strains and species of experimental animals. (PubMed id 8982120)9 Sillevis Smitt P....Posner J. (J. Neuroimmunol. 1996)
    126. Purification and properties of HuD, a neuronal RNA-binding protein. (PubMed id 8626712)9 Chung S....Furneaux H. (J. Biol. Chem. 1996)
    127. Accumulation of sequence-specific RNA-binding proteins in the cytosol of activated T cells undergoing RNA degradation and apoptosis. (PubMed id 7592882)9 Mondino A. and Jenkins M.K. (J. Biol. Chem. 1995)
    128. Tissue-specific expression of the gene encoding a mouse RNA binding protein homologous to human HuD antigen. (PubMed id 8535975)9 Abe R....Sakamoto H. (DNA Res. 1994)
    129. CPEB is a specificity factor that mediates cytoplasmic polyadenylation during Xenopus oocyte maturation. (PubMed id 7954828)9 Hake L.E. and Richter J.D. (Cell 1994)
    130. Electrostatic interactions modulate the RNA-binding and transactivation specificities of the human immunodeficiency virus and simian immunodeficiency virus Tat proteins. (PubMed id 8434019)9 Tao J. and Frankel A.D. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    131. Hel-N1: an autoimmune RNA-binding protein with specificity for 3' uridylate-rich untranslated regions of growth factor mRNAs. (PubMed id 8497264)9 Levine T.D....Keene J.D. (Mol. Cell. Biol. 1993)
    132. Oligomerization and RNA binding domains of the type 1 human immunodeficiency virus Rev protein: a dual function for an arginine-rich binding motif. (PubMed id 1715576)9 Zapp M.L....Green M.R. (Proc. Natl. Acad. Sci. U.S.A. 1991)
    133. HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequence. (PubMed id 2406030)9 Malim M.H....Cullen B.R. (Cell 1990)
    134. The Neuronal Splicing Factor Nova Co-Localizes with Target RNAs in the Dendrite. (PubMed id 20407637)9 Racca C....Darnell R.B. (Front Neural Circuits 2010)
    135. Northwestern profiling of potential translation-regulatory proteins in human breast epithelial cells and malignant breast tissues: evidence for pathological activation of the IGF1R IRES. (PubMed id 20233590)9 Blume S.W....Meng Z. (Exp. Mol. Pathol. 2010)
    136. The epithelial splicing factors ESRP1 and ESRP2 positively and negatively regulate diverse types of alternative splicing events. (PubMed id 19829082)9 Warzecha C.C....Carstens R.P. (RNA Biol 2009)
    137. Derivation of male germ cell-like lineage from human fetal bone marrow stem cells. (PubMed id 19573297)9 Hua J....Sidhu K.S. (Reprod. Biomed. Online 2009)
    138. Role of RNA chaperones in virus replication. (PubMed id 18675859)9 ZA_A+iga S....Enjuanes L. (Virus Res. 2009)
    139. Gene polymorphisms/mutations relevant to abnormal spermatogenesis. (PubMed id 18413059)9 Nuti F. and Krausz C. (Reprod. Biomed. Online 2008)
    140. A Caenorhabditis elegans PUF protein family with distinct RNA binding specificity. (PubMed id 18579869)9 Stumpf C.R....Wickens M. (RNA 2008)
    141. Premature ovarian failure (POF) syndrome: towards the molecular clinical analysis of its genetic complexity. (PubMed id 16719785)9 Fassnacht W....Vogt P.H. (Curr. Med. Chem. 2006)
    142. In vivo post-transcriptional regulation of GAP-43 mRNA by overexpression of the RNA-binding protein HuD. (PubMed id 16405504)9 Bolognani F....Perrone-Bizzozero N.I. (J. Neurochem. 2006)
    143. Regulation of gene expression in post-meiotic male germ cells: CREM-signalling pathways and male fertility. (PubMed id 16825108)9 Hogeveen K.N. and Sassone-Corsi P. (Hum Fertil (Camb) 2006)
    144. CPEB3 and CPEB4 in neurons: analysis of RNA-binding specificity and translational control of AMPA receptor GluR2 mRNA. (PubMed id 17024188)9 Huang Y.S....Richter J.D. (EMBO J. 2006)
    145. A putative nuclear function for mammalian Staufen. (PubMed id 15896738)9 Kiebler M.A....Macchi P. (Trends Biochem. Sci. 2005)
    146. Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. (PubMed id 15744350)9 Prima V.... Hunger S.P. (Leukemia 2005)
    147. Role of the DAZ genes in male fertility. (PubMed id 15705297)9 Reynolds N. and Cooke H.J. (Reprod. Biomed. Online 2005)
    148. Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate. (PubMed id 12832361)9 Fisher J.S....Sharpe R.M. (Hum. Reprod. 2003)
    149. Idiopathic cases of male infertility from a region in India show low incidence of Y-chromosome microdeletion. (PubMed id 14517364)9 Ambasudhan R....Raman R. (J. Biosci. 2003)
    150. Role of HuD and other RNA-binding proteins in neural development and plasticity. (PubMed id 11948657)9 Perrone-Bizzozero N. and Bolognani F. (J. Neurosci. Res. 2002)
    151. cis-acting regulatory elements in the GAP-43 mRNA 3'-untranslated region can function in trans to suppress endogenous GAP-43 gene expression. (PubMed id 10036307)9 Neve R.L....Perrone-Bizzozero N.I. (Brain Res. Mol. Brain Res. 1999)
    152. Biphasic subcellular localization of the DAZL-related protein boule in Drosophila spermatogenesis. (PubMed id 9882490)9 Cheng M.H....Wasserman S.A. (Dev. Biol. 1998)
    153. Neuron-specific hel-N1 and HuD as novel molecular markers of neuroblastoma: a correlation of HuD messenger RNA levels with favorable prognostic features. (PubMed id 9815574)9 Ball N.S. and King P.H. (Clin. Cancer Res. 1997)

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    Entrez Gene: 1618 HGNC: 2685 AceView: DAZL Ensembl:ENSG00000092345 euGenes: HUgn1618
    ECgene: DAZL H-InvDB: DAZL

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    PharmGKB entry for DAZL Pharmacogenomics, SNPs, Pathways

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