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Aliases for DAZL Gene

Aliases for DAZL Gene

  • Deleted In Azoospermia-Like 2 3
  • SPGYLA 3 4 6
  • DAZH 3 4 6
  • Deleted In Azoospermia-Like 1 3 4
  • SPGY-Like-Autosomal 3 4
  • DAZ-Like Autosomal 3 4
  • DAZ Homolog 3 4
  • DAZLA 3 4
  • DAZL1 3 4
  • Spermatogenesis Gene On The Y-Like Autosomal 3
  • Germline Specific RNA Binding Protein 3

External Ids for DAZL Gene

Previous HGNC Symbols for DAZL Gene

  • DAZLA

Previous GeneCards Identifiers for DAZL Gene

  • GC03M016557
  • GC03M016603

Summaries for DAZL Gene

Entrez Gene Summary for DAZL Gene

  • The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for DAZL Gene

DAZL (Deleted In Azoospermia-Like) is a Protein Coding gene. Diseases associated with DAZL include azoospermia and paraneoplastic syndromes. Among its related pathways are Translational Control and Ovarian Infertility Genes. GO annotations related to this gene include RNA binding and translation activator activity. An important paralog of this gene is DAZ4.

UniProtKB/Swiss-Prot for DAZL Gene

  • RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).

Gene Wiki entry for DAZL Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAZL Gene

Genomics for DAZL Gene

Regulatory Elements for DAZL Gene

Genomic Location for DAZL Gene

Start:
16,586,792 bp from pter
End:
16,670,306 bp from pter
Size:
83,515 bases
Orientation:
Minus strand

Genomic View for DAZL Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAZL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAZL Gene

Proteins for DAZL Gene

  • Protein details for DAZL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92904-DAZL_HUMAN
    Recommended name:
    Deleted in azoospermia-like
    Protein Accession:
    Q92904
    Secondary Accessions:
    • O15396
    • Q5HYB4
    • Q92909

    Protein attributes for DAZL Gene

    Size:
    295 amino acids
    Molecular mass:
    33178 Da
    Quaternary structure:
    • Homodimer and heterodimer. Multiple DAZL RRMs can bind to a single RNA containing multiple GUU triplets (By similarity). Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2.

    Alternative splice isoforms for DAZL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAZL Gene

Proteomics data for DAZL Gene at MOPED

Post-translational modifications for DAZL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAZL Gene

No data available for DME Specific Peptides for DAZL Gene

Domains for DAZL Gene

Gene Families for DAZL Gene

HGNC:
  • RBM :RNA binding motif (RRM) containing

Protein Domains for DAZL Gene

Suggested Antigen Peptide Sequences for DAZL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92904

UniProtKB/Swiss-Prot:

DAZL_HUMAN :
  • Q92904
Domain:
  • The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2.
  • Contains 1 DAZ-like domain.
  • Contains 1 RRM (RNA recognition motif) domain.
Family:
  • Belongs to the RRM DAZ family.
genes like me logo Genes that share domains with DAZL: view

Function for DAZL Gene

Molecular function for DAZL Gene

GENATLAS Biochemistry: deleted in azoospermia,autosomal-like,homolog of the mouse Dazla gene and the Drosophila boule (SPGY like autosomal),expressed only in male gonad
UniProtKB/Swiss-Prot Function: RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).

Gene Ontology (GO) - Molecular Function for DAZL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
GO:0003730 mRNA 3-UTR binding --
GO:0005515 protein binding IPI 16001084
genes like me logo Genes that share ontologies with DAZL: view

Phenotypes for DAZL Gene

MGI mutant phenotypes for DAZL:
inferred from 1 alleles
GenomeRNAi human phenotypes for DAZL:
genes like me logo Genes that share phenotypes with DAZL: view

Animal Models for DAZL Gene

MGI Knock Outs for DAZL:

miRNA for DAZL Gene

miRTarBase miRNAs that target DAZL

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DAZL Gene

Localization for DAZL Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAZL Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAZL Gene COMPARTMENTS Subcellular localization image for DAZL gene
Compartment Confidence
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for DAZL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0005844 polysome --
genes like me logo Genes that share ontologies with DAZL: view

Pathways for DAZL Gene

genes like me logo Genes that share pathways with DAZL: view

Pathways by source for DAZL Gene

1 Cell Signaling Technology pathway for DAZL Gene
1 BioSystems pathway for DAZL Gene

Gene Ontology (GO) - Biological Process for DAZL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001556 oocyte maturation --
GO:0007147 female meiosis II --
GO:0007275 multicellular organismal development IEA --
GO:0007281 germ cell development TAS 9288969
GO:0007283 spermatogenesis IEA --
genes like me logo Genes that share ontologies with DAZL: view

Compounds for DAZL Gene

(2) Novoseek inferred chemical compound relationships for DAZL Gene

Compound -log(P) Hits PubMed IDs
vas-a 55.3 13
adenylate 0.705 1
genes like me logo Genes that share compounds with DAZL: view

Transcripts for DAZL Gene

mRNA/cDNA for DAZL Gene

Unigene Clusters for DAZL Gene

Deleted in azoospermia-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DAZL Gene

No ASD Table

Relevant External Links for DAZL Gene

GeneLoc Exon Structure for
DAZL
ECgene alternative splicing isoforms for
DAZL

Expression for DAZL Gene

mRNA expression in normal human tissues for DAZL Gene

mRNA differential expression in normal tissues according to GTEx for DAZL Gene

This gene is overexpressed in Testis (51.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DAZL Gene

SOURCE GeneReport for Unigene cluster for DAZL Gene Hs.131179

mRNA Expression by UniProt/SwissProt for DAZL Gene

Q92904-DAZL_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expressions with DAZL: view

Orthologs for DAZL Gene

This gene was present in the common ancestor of animals.

Orthologs for DAZL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAZL 35
  • 99.89 (n)
  • 99.66 (a)
DAZL1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DAZL 35
  • 92.74 (n)
  • 91.84 (a)
DAZL 36
  • 92 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 41 (a)
OneToMany
DAZL 35
  • 93.76 (n)
  • 92.86 (a)
mouse
(Mus musculus)
Mammalia Dazl 16
Dazl 36
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 68 (a)
OneToMany
chicken
(Gallus gallus)
Aves DAZL 36
  • 65 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 65 (a)
OneToMany
African clawed frog
(Xenopus laevis)
Amphibia dazl 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dazl 35
zebrafish
(Danio rerio)
Actinopterygii dazl 35
dazl 36
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta bol 36
  • 25 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea daz-1 36
  • 15 (a)
OneToMany
Species with no ortholog for DAZL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAZL Gene

ENSEMBL:
Gene Tree for DAZL (if available)
TreeFam:
Gene Tree for DAZL (if available)

Paralogs for DAZL Gene

Paralogs for DAZL Gene

Selected SIMAP similar genes for DAZL Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DAZL Gene

genes like me logo Genes that share paralogs with DAZL: view

Variants for DAZL Gene

Sequence variations from dbSNP and Humsavar for DAZL Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type MAF
rs930039 -- 16,589,230(+) AAAAA(A/T)TTTAA intron-variant
rs1048958 -- 16,588,450(-) GAAAG(C/T)AAAAA utr-variant-3-prime
rs1048960 -- 16,586,835(-) GATAC(C/T)GTCTT utr-variant-3-prime
rs1130313 -- 16,598,594(-) GTCTA(C/T)TGCAA reference, missense
rs1808518 -- 16,586,299(+) ACTAA(A/C)TGATG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for DAZL Gene

Variant ID Type Subtype PubMed ID
nsv834625 CNV Gain 17160897
esv22139 CNV Loss 19812545
dgv796n67 CNV Loss 20364138
nsv876586 CNV Loss 21882294
nsv509814 CNV Loss 20534489
nsv822018 CNV Loss 20364138
nsv822019 CNV Loss 20364138
nsv822021 CNV Loss 20364138
dgv798n67 CNV Loss 20364138
esv997976 CNV Gain 20482838
nsv822024 CNV Loss 20364138
nsv822025 CNV Loss 20364138

Relevant External Links for DAZL Gene

HapMap Linkage Disequilibrium report
DAZL
Human Gene Mutation Database (HGMD)
DAZL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAZL Gene

Disorders for DAZL Gene

(2) University of Copenhagen DISEASES for DAZL Gene

(16) Novoseek inferred disease relationships for DAZL Gene

Disease -log(P) Hits PubMed IDs
azoospermia 86.9 29
infertility male 74.1 15
paraneoplastic encephalomyelitis 70.6 1
oligozoospermia 70.5 4
infertility 52.4 4

Relevant External Links for DAZL

Genetic Association Database (GAD)
DAZL
Human Genome Epidemiology (HuGE) Navigator
DAZL
genes like me logo Genes that share disorders with DAZL: view

No data available for UniProtKB/Swiss-Prot for DAZL Gene

Publications for DAZL Gene

  1. A putative human male infertility gene DAZLA: genomic structure and methylation status. (PMID: 9294855) Chai N.-N. … Yen P.H. (Mol. Hum. Reprod. 1997) 3 4 23
  2. A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad. (PMID: 8968755) Shan Z. … Vogt P.H. (Hum. Mol. Genet. 1996) 3 4 23
  3. The human autosomal gene DAZLA: testis specificity and a candidate for male infertility. (PMID: 8968756) Yen P.H. … Salido E.C. (Hum. Mol. Genet. 1996) 3 4 23
  4. Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PMID: 10857750) Tsui S. … Yen P.H. (Genomics 2000) 3 4 23
  5. A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. (PMID: 11390979) Xu E.Y. … Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4 23

Products for DAZL Gene

Sources for DAZL Gene

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