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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAZL Gene

protein-coding   GIFtS: 60
GCID: GC03M016603

deleted in azoospermia-like


(Previous symbol: DAZLA)
 Explore 20 diseases affiliated with
DAZL via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DAZL    

Aliases
for DAZL gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Deleted In Azoospermia-Like1 2     SPGY-Like-Autosomal1
DAZH1 2 3 5     DAZ Homolog2 3
SPGYLA1 2 3 5     DAZ-Like Autosomal2 3
DAZL11 2 3     MGC264061
DAZLA1 2 3     Germline Specific RNA Binding Protein2
Deleted In Azoospermia-Like 12 3     Spermatogenesis Gene On The Y-Like Autosomal2

External Ids:    HGNC: 26851   Entrez Gene: 16182   Ensembl: ENSG000000923457   OMIM: 6014865   UniProtKB: Q929043   

Export aliases for DAZL gene to outside databases

Previous GC identifer: GC03M016557


Summaries
for DAZL gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DAZL:
The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and
postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm
of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the
nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and
spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene
cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility
in males. Two transcript variants encoding different isoforms have been found for this gene. (provided by RefSeq, Jun
2010)

UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
Function: RNA-binding protein, which is essential for gametogenesis. Plays a central role during spermatogenesis. May
act by binding to the 3'-UTR of mRNA and thereby regulating the translation of key transcripts (By similarity)

Gene Wiki entry for DAZL


Genomic Views
for DAZL gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000003.11  NC_018914.1  NT_022517.18  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAZL gene promoter:
         Max1   Pbx1a   Pax-6   MEF-2A   AREB6   FOXJ2 (long isoform)   aMEF-2   FOXJ2   RSRFC4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DAZL promoter sequence
   Search SABiosciences Chromatin IP Primers for DAZL

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAZL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24

DAZL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAZL gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M016603:  view genomic region     (about GC identifiers)

Start:
 16,628,299 bp from pter      End:
 16,711,813 bp from pter
Size:
 83,515 bases      Orientation:
 minus strand

Proteins
for DAZL gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904 (See protein sequence)
Recommended Name: Deleted in azoospermia-like  
Size: 295 amino acids; 33178 Da
Subunit: Homodimer and heterodimer (By similarity). Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and
DAZAP2. Interacts with PUM2
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (By
similarity). Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from
then onward (By similarity)
Secondary accessions: O15396 Q5HYB4 Q92909
Alternative splicing: 2 isoforms:  Q92904-1   Q92904-2   

Explore the universe of human proteins at neXtProt for DAZL: NX_Q92904

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q92904

    • DAZL Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177740.1  NP_001342.2  

    ENSEMBL proteins: 
     ENSP00000250863   ENSP00000382373   ENSP00000398109  

    Human Recombinant Protein Products: 
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    OriGene Protein Over-expression Lysate (see all 2): DAZL
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    Novus Biologicals DAZL Protein
    Novus Biologicals DAZL Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DAZL

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005844polysome ----
    GO:0044464cell part ----


    DAZL for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DAZL

    Protein Domains /
    Families
    for DAZL gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DAZL for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q92904

    ProtoNet protein and cluster: Q92904

    1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
    Domain: The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2
    Similarity: Belongs to the RRM DAZ family
    Similarity: Contains 1 DAZ-like domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Function
    for DAZL gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
    Function: RNA-binding protein, which is essential for gametogenesis. Plays a central role during spermatogenesis. May
    act by binding to the 3'-UTR of mRNA and thereby regulating the translation of key transcripts (By similarity)

         Genatlas biochemistry entry for DAZL:
    deleted in azoospermia,autosomal-like,homolog of the mouse Dazla gene and the Drosophila boule (SPGY like
    autosomal),expressed only in male gonad

    miRNA
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    hsa-miR-3938 hsa-miR-607 hsa-miR-3664-5p hsa-miR-4328 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmid: DAZL 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAZL (see all 7)
    OriGene shRNA RFP: DAZL
    OriGene siRNA: DAZL
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAZL

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DAZL (NM_001351)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAZL 

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    In Situ Assay
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    Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0003730mRNA 3'-UTR binding ----
    GO:0005515protein binding IPI16001084


    DAZL for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DAZL:
     Increased G2M DNA content 

    Animal Models:
         Mouse knock-out Dazltm1Hjc for DAZL
         2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dazl):
     endocrine/exocrine gland  reproductive system 

    DAZL for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DAZL gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Ovarian Infertility Genes
    		Ovarian Infertility Genes1.00
    2Translational Control
    		Translational Control1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DAZL
        Translational Control

    1 BioSystems Pathway for DAZL 
        Ovarian Infertility Genes



    DAZL for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAZL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/11 Interacting proteins for DAZL (Q929043 ENSP000003823734) via UniProtKB, MINT, STRING, and/or I2D (see all 11)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAZ1Q9NQZ33, ENSP000003845734I2D: score=3 STRING: ENSP00000384573
    DAZAP1Q96EP53, ENSP000002330784I2D: score=2 STRING: ENSP00000233078
    DCTN1Q142033, ENSP000003547914I2D: score=1 STRING: ENSP00000354791
    DCTN2Q135613, ENSP000004089104I2D: score=1 STRING: ENSP00000408910
    PUM2Q8TB723, ENSP000003381734I2D: score=1 STRING: ENSP00000338173
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007281germ cell development TAS9288969
    GO:0007283spermatogenesis IEA--
    GO:0045836positive regulation of meiosis ----
    GO:0045948positive regulation of translational initiation IDA16001084


    DAZL for ontologies           About GeneDecksing



    Drugs & Compounds
    for DAZL gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DAZL for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DAZL
    2 Novoseek chemical compound relationships for DAZL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vas-a 55.3 14 18088417 (8), 16228988 (2), 19573297 (1), 19602557 (1) (see all 5)
    adenylate 0.705 4 10819768 (1)

    Search CenterWatch for drugs/clinical trials and news about DAZL 

    Transcripts
    for DAZL gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DAZL gene (2 alternative transcripts): 
    NM_001190811.1  NM_001351.3  

    Unigene Cluster for DAZL:

    Deleted in azoospermia-like
    Hs.131179  [show with all ESTs]
    Unigene Representative Sequence: NM_001190811
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250863(uc003cba.3) ENST00000399444(uc003cbb.3) ENST00000454457


    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAZL
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate DAZL (see all 22):
    hsa-miR-3938 hsa-miR-607 hsa-miR-3664-5p hsa-miR-4328 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmid: DAZL 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector (see first 1): DAZL (NM_001351  NM_001190811)
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAZL
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAZL

    Additional cDNA sequence: 

    AK303026.1 AK310341.1 BC027595.2 BX648638.1 U65918.1 U66078.1 U66726.2 

    2 DOTS entries:

    DT.310516  DT.97804595 

    24/52 AceView cDNA sequences (see all 52):

    BX648638 AL705991 NM_001351 BF980336 BI460958 CD557344 BI463630 AW341566 
    BU853969 AL044707 BI464057 BI461267 BU569412 BI459106 BV199496 BG771817 
    AA774538 BI464024 U65918 CD300236 BI829533 BG210841 BQ441372 U66726 

    GeneLoc Exon Structure


    Expression
    for DAZL gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAZL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AATAAAAATA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DAZL expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    3 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Reproductive SystemEarly GonadPrimordial Germ CellsGerm Cells
    OvaryOvigerous CordXX Germ CellsFemale Gametocytes, Germ Cells
    TestisSeminiferous TubulesSpermatogonium Type AGerm Cells, Male Gametocytes
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10/11 LifeMap Cells (see all 11) 
    NameCategory
    Ovarian tissue-dissociated cells (Primary Cell)Reproductive System
    Ovarian tissue-dissociated cells (human) (Primary Cell)Ovary, Reproductive System
    ES-J1 (Embryonic Stem Cell)Early Embryo, Inner Cell Mass
    Primordial germ-like cells (Derivation of embryo...)
    Embryoid bodies (Derivation of post-m...)
    Primordial-like germ cells (cKIT+ SSEA1+ VASA+) (Derivation of primor...)
    Embryoid bodies (Derivation of embryo...)
    Short-term differentiated embryoid bodies (Derivation of embryo...)
    Primordial germ cell-like cells (Reconstitution of mo...)
    Human oogonial stem cells (Oocyte formation by ...)

    See DAZL Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAZL

    SOURCE GeneReport for Unigene cluster: Hs.131179

    UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
    Tissue specificity: Testis specific

        SABiosciences Custom PCR Arrays for DAZL
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAZL

    Orthologs
    for DAZL gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for DAZL gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dazl5 deleted in azoospermia-like   --   17 (25.86 cM) 50279394 
    chicken
    (Gallus gallus)    		 Aves DAZL1 deleted in azoospermia-like 73.38(n)
    70.67(a)    		   374054  NM_204218.1  NP_989549.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    		 --
    		 71(a)
    		 1 → many
    		 6(34873522-34886921)
    African clawed frog
    (Xenopus laevis)    		 Amphibia dazl2 DAZ-like protein 77.98(n)    AF017778.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dazl2 daz-like gene 73.65(n)   58039  AB018191.1 


    ENSEMBL Gene Tree for DAZL (if available)
    TreeFam Gene Tree for DAZL (if available) 

    Paralogs
    for DAZL gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DAZL gene
    DAZ12  DAZ32  DAZ42  DAZ22  BOLL2  
    8 SIMAP similar genes for DAZL using alignment to 3 protein entries:     DAZL_HUMAN (see all proteins):
    DAZ3    DAZ4    DAZ2    DAZ1    BOLL    RBMY1A1
    RBFOX2    HNRNPA2B1

    DAZL for paralogs           About GeneDecksing


    4 Pseudogenes.org Pseudogenes for DAZL
    PGOHUM00000233822 PGOHUM00000233854 PGOHUM00000234035 PGOHUM00000234068


    Genomic Variants
    for DAZL gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/450 NCBI SNPs in DAZL are shown (see all 450)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 3 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs610935751,2
    		--16561649(+) ATTGGG/TAGTAC 2 -- int10--------
    rs751483541,2
    		F,--16561708(+) CATCCA/GTAAGA 2 -- int11Minor allele frequency- G:0.02WA 118
    rs170424401,2
    		C,F,,--16561754(+) GCAACC/TGCAAT 2 -- int13Minor allele frequency- T:0.01NA 138
    rs105104531,2
    		C,F,H,--16561797(+) AAAGCG/ATACAG 2 -- int1104Minor allele frequency- A:0.09NS NA EA PA EU CA WA CSA 6304
    rs731425091,2
    		C,--16562740(+) TCTTTA/GTATCA 2 -- ut312Minor allele frequency- G:0.04WA 120
    rs556797521,2
    		C--16562808(+) GTGGTG/-ATAGC 2 -- ut311Minor allele frequency- -:0.00NA 2
    rs774289561,2
    		C,F,--16563381(+) GGACTG/ATTCGC 2 -- ut311Minor allele frequency- A:0.03WA 118
    rs170424431,2
    		C,F,H,--16563592(+) ACCAAC/GAAAAT 2 -- ut318Minor allele frequency- G:0.03NA NS EA WA 662
    rs123741511,2
    		C,F,H,--16564278(+) TTTATG/ATACTT 2 -- int115Minor allele frequency- A:0.09NS EA NA 1740
    rs1136611981,2
    		F--16564996(+) AAACTC/TTGGGA 2 -- int12Minor allele frequency- T:0.50CSA 4

    HapMap Linkage Disequilibrium report for DAZL (16628299 - 16711813 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 3 variations for DAZL
         3 CNVs: 68344 68343 68341
    Human Gene Mutation Database (HGMD): DAZL

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DAZL
    DNA2.0 Custom Variant and Variant Library Synthesis for DAZL

    Disorders / Diseases
    for DAZL gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DAZL for disorders           About GeneDecksing

    OMIM gene information: 601486    OMIM disorders: --

    20 diseases for DAZL:    About MalaCards
    spermatogenic failure    azoospermia    infertility    paraneoplastic neurologic disorders
    paraneoplastic syndromes    premature ovarian failure    male infertility    acute lymphoblastic leukemia
    lymphoblastic leukemia    seminoma    encephalomyelitis    hermaphroditism
    medulloblastoma    immunodeficiency    breast carcinoma    leukemia
    lung cancer    carcinoma    neuroblastoma    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for DAZL:
    Male infertility     Infertility

    10/16 Novoseek disease relationships for DAZL gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azoospermia 86.9 37 9783841 (2), 9294855 (2), 16123080 (2), 10527983 (1) (see all 26)
    infertility male 74.1 17 9294855 (3), 16573709 (2), 17918711 (2), 8968756 (2) (see all 9)
    paraneoplastic encephalomyelitis 70.6 1 8982120 (1)
    oligozoospermia 70.5 5 9294855 (2), 16573709 (1), 16123080 (1)
    infertility 52.4 5 20300286 (1), 11604102 (1), 17918711 (1), 14965334 (1)
    sterility male 51.7 3 9143498 (2), 16844779 (1)
    ovarian failure premature 50.8 2 10527983 (1)
    chromosome deletion 38.4 1 10601091 (1)
    paraneoplastic syndromes 27.4 1 10735272 (1)
    seminoma 18.4 7 11956819 (3), 16228988 (2)

    Genetic Association Database (GAD): DAZL
    Human Genome Epidemiology (HuGE) Navigator: DAZL (12 documents)

    Export disorders for DAZL gene to outside databases

    Publications
    for DAZL gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAZL gene, integrated from 9 sources (see all 154):
    (articles sorted by number of sources associating them with DAZL)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of a single-nucleotide polymorphism of the deleted-in- azoospermia-like gene with susceptibility to spermatogenic failure. (PubMed id 12414900)1, 2, 4 Teng Y.-N.... Kuo P.-L. (2002)
    2. The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. (PubMed id 8896558)1, 2, 3 Saxena R....Page D.C. (1996)
    3. A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad. (PubMed id 8968755)1, 2, 9 Shan Z.... Vogt P.H. (1996)
    4. A putative human male infertility gene DAZLA: genomic structure and methylation status. (PubMed id 9294855)1, 2, 9 Chai N.-N.... Yen P.H. (1997)
    5. The human autosomal gene DAZLA: testis specificity and a candidate for male infertility. (PubMed id 8968756)1, 2, 9 Yen P.H.... Salido E.C. (1996)
    6. Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PubMed id 10857750)1, 2, 9 Tsui S.... Yen P.H. (2000)
    7. Survey of the two polymorphisms in DAZL, an autosomal candidate for the azoospermic factor, in Japanese infertile men and implications for male infertility. (PubMed id 16123080)1, 4, 9 Yang X.J....Nakahori Y. (2005)
    8. A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. (PubMed id 11390979)1, 2, 9 Xu E.Y.... Reijo Pera R.A. (2001)
    9. No association of the A260G and A386G DAZL single nucleotide polymorphisms with male infertility in a Caucasian population. (PubMed id 15520024)1, 4, 9 Tschanter P....Gromoll J. (2004)
    10. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)1, 2, 9 Moore F.L.... Reijo Pera R.A. (2003)

    External Searches for DAZL gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DAZL gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1618 HGNC: 2685 AceView: DAZL Ensembl:ENSG00000092345 euGenes: HUgn1618
    ECgene: DAZL H-InvDB: DAZL

    Other Databases showing DAZL gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DAZL gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAZL Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DAZL gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DAZL gene:
    Search GeneIP for patents involving DAZL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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