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DAZL Gene(Protein Coding)

Deleted In Azoospermia Like

GCID:
GC03M016586
GIFtS:
57
Genes Participants
UDN Logo

Aliases for DAZL Gene

Aliases for DAZL Gene

  • Deleted In Azoospermia Like 2 3 5
  • Deleted In Azoospermia-Like 1 3 4
  • Deleted In Azoospermia-Like 2 3
  • SPGY-Like-Autosomal 3 4
  • DAZ-Like Autosomal 3 4
  • DAZ Homolog 3 4
  • SPGYLA 3 4
  • DAZLA 3 4
  • DAZL1 3 4
  • DAZH 3 4
  • Testis Secretory Sperm-Binding Protein Li 204a 3
  • Spermatogenesis Gene On The Y-Like Autosomal 3
  • Germline Specific RNA Binding Protein 3

External Ids for DAZL Gene

Previous HGNC Symbols for DAZL Gene

  • DAZLA

Previous GeneCards Identifiers for DAZL Gene

  • GC03M016557
  • GC03M016603

Summaries for DAZL Gene

Entrez Gene Summary for DAZL Gene

  • The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for DAZL Gene

DAZL (Deleted In Azoospermia Like) is a Protein Coding gene. Diseases associated with DAZL include Azoospermia and Infertility. Among its related pathways are Translational Control and Ovarian Infertility Genes. GO annotations related to this gene include nucleic acid binding and RNA binding. An important paralog of this gene is DAZ1.

UniProtKB/Swiss-Prot for DAZL Gene

  • RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).

Gene Wiki entry for DAZL Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAZL Gene

Genomics for DAZL Gene

Products:

  1. Regulatory Element

Regulatory Elements for DAZL Gene

Enhancers for DAZL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03G016361 0.6 FANTOM5 37.4 +309.0 309009 0.1 MAFG CEBPG JUND ATF3 NFE2L1 NFE2 FOS MAFK NFE2L2 DAZL RFTN1 ENSG00000272529 GC03P016476
GH03G016605 0.7 FANTOM5 ENCODE 10.3 +64.3 64291 1.7 RELA DAZL PIR37155 GC03M016595
GH03G016670 0.8 ENCODE dbSUPER 0.7 -0.2 -193 0.2 ZNF316 BCL11A TEAD4 POU5F1 FOS NFE2 DAZL PIR34564
GH03G016671 0.8 ENCODE dbSUPER 0.7 -1.3 -1334 1.8 FOXA2 POU5F1 CHD7 ZNF558 DAZL PIR34564
GH03G016662 1.4 Ensembl ENCODE dbSUPER 0.4 +5.5 5535 4.9 INSM2 KLF17 BRCA1 ZNF2 GLIS2 ZNF366 FOS ZNF391 ZNF263 ZNF362 DAZL PIR37155 GC03M016595
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DAZL on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DAZL gene promoter:

Genomic Location for DAZL Gene

Chromosome:
3
Start:
16,586,792 bp from pter
End:
16,670,306 bp from pter
Size:
83,515 bases
Orientation:
Minus strand

Genomic View for DAZL Gene

Genes around DAZL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAZL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAZL Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DAZL Gene

Proteins for DAZL Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DAZL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q92904-DAZL_HUMAN
    Recommended name:
    Deleted in azoospermia-like
    Protein Accession:
    Q92904
    Secondary Accessions:
    • O15396
    • Q5HYB4
    • Q92909

    Protein attributes for DAZL Gene

    Size:
    295 amino acids
    Molecular mass:
    33178 Da
    Quaternary structure:
    • Homodimer and heterodimer. Multiple DAZL RRMs can bind to a single RNA containing multiple GUU triplets (By similarity). Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2.

    Alternative splice isoforms for DAZL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAZL Gene

Protein Expression for DAZL Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DAZL Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAZL Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DAZL (DAZL)
  • Santa Cruz Biotechnology (SCBT) Antibodies for DAZL

No data available for DME Specific Peptides for DAZL Gene

Domains & Families for DAZL Gene

Gene Families for DAZL Gene

HGNC:

Protein Domains for DAZL Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for DAZL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q92904

UniProtKB/Swiss-Prot:

DAZL_HUMAN :
  • The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2.
  • Belongs to the RRM DAZ family.
Domain:
  • The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2.
Family:
  • Belongs to the RRM DAZ family.
genes like me logo Genes that share domains with DAZL: view

Function for DAZL Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line

Molecular function for DAZL Gene

GENATLAS Biochemistry:
deleted in azoospermia,autosomal-like,homolog of the mouse Dazla gene and the Drosophila boule (SPGY like autosomal),expressed only in male gonad
UniProtKB/Swiss-Prot Function:
RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central role during spermatogenesis. Acts by binding to the 3-UTR of mRNA, specifically recognizing GUU triplets, and thereby regulating the translation of key transcripts (By similarity).

Gene Ontology (GO) - Molecular Function for DAZL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding IEA --
GO:0003723 RNA binding TAS 8968755
GO:0003730 mRNA 3-UTR binding IEA --
GO:0005515 protein binding IPI 16001084
GO:0008494 translation activator activity IDA 16001084
genes like me logo Genes that share ontologies with DAZL: view
genes like me logo Genes that share phenotypes with DAZL: view

Animal Model Products

CRISPR Products

miRNA for DAZL Gene

miRTarBase miRNAs that target DAZL

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DAZL Gene

Localization for DAZL Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAZL Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAZL gene
Compartment Confidence
nucleus 5
cytosol 3
extracellular 1
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DAZL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA,TAS --
GO:0005844 polysome IEA --
genes like me logo Genes that share ontologies with DAZL: view

Pathways & Interactions for DAZL Gene

genes like me logo Genes that share pathways with DAZL: view

Pathways by source for DAZL Gene

1 Cell Signaling Technology pathway for DAZL Gene
1 BioSystems pathway for DAZL Gene

Gene Ontology (GO) - Biological Process for DAZL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001556 oocyte maturation IEA --
GO:0006417 regulation of translation IEA --
GO:0007147 female meiosis II IEA --
GO:0007275 multicellular organism development IEA --
GO:0007281 germ cell development TAS 9288969
genes like me logo Genes that share ontologies with DAZL: view

No data available for SIGNOR curated interactions for DAZL Gene

Drugs & Compounds for DAZL Gene

Products:

  1. Drug

(2) Additional Compounds for DAZL Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DAZL: view

Transcripts for DAZL Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone

mRNA/cDNA for DAZL Gene

(2) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(52) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DAZL Gene

Deleted in azoospermia-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAZL Gene

No ASD Table

Relevant External Links for DAZL Gene

GeneLoc Exon Structure for
DAZL
ECgene alternative splicing isoforms for
DAZL

Expression for DAZL Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DAZL Gene

mRNA expression in normal human tissues for DAZL Gene
mRNA expression by BioGPS for DAZL GenemRNA expression by GTEx for DAZL Gene

mRNA differential expression in normal tissues according to GTEx for DAZL Gene

This gene is overexpressed in Testis (x51.0).

Protein differential expression in normal tissues from HIPED for DAZL Gene

This gene is overexpressed in Fetal ovary (33.0), Testis (23.8), and Ovary (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DAZL Gene



Protein tissue co-expression partners for DAZL Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DAZL Gene:

DAZL

SOURCE GeneReport for Unigene cluster for DAZL Gene:

Hs.131179

mRNA Expression by UniProt/SwissProt for DAZL Gene:

Q92904-DAZL_HUMAN
Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with DAZL: view

Primer Products

No data available for Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAZL Gene

Orthologs for DAZL Gene

This gene was present in the common ancestor of animals.

Orthologs for DAZL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DAZL1 35
  • 100 (a)
 OneToOne
DAZL 34
  • 99.89 (n)
dog
(Canis familiaris)
 Mammalia DAZL 34
  • 93.76 (n)
-- 35
  • 41 (a)
 OneToMany
cow
(Bos Taurus)
 Mammalia DAZL 34 35
  • 92.74 (n)
mouse
(Mus musculus)
 Mammalia Dazl 35
  • 87 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia -- 35
  • 84 (a)
 OneToMany
platypus
(Ornithorhynchus anatinus)
 Mammalia -- 35
  • 68 (a)
 OneToMany
chicken
(Gallus gallus)
 Aves DAZL 35
  • 65 (a)
 OneToMany
lizard
(Anolis carolinensis)
 Reptilia -- 35
  • 65 (a)
 OneToMany
tropical clawed frog
(Silurana tropicalis)
 Amphibia dazl 34
African clawed frog
(Xenopus laevis)
 Amphibia dazl 34
zebrafish
(Danio rerio)
 Actinopterygii dazl 34 35
  • 38 (a)
fruit fly
(Drosophila melanogaster)
 Insecta bol 35
  • 25 (a)
 OneToMany
worm
(Caenorhabditis elegans)
 Secernentea daz-1 35
  • 15 (a)
 OneToMany
Species where no ortholog for DAZL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAZL Gene

ENSEMBL:
Gene Tree for DAZL (if available)
TreeFam:
Gene Tree for DAZL (if available)

Paralogs for DAZL Gene

Paralogs for DAZL Gene

(8) SIMAP similar genes for DAZL Gene using alignment to 3 proteins:

Pseudogenes.org Pseudogenes for DAZL Gene

genes like me logo Genes that share paralogs with DAZL: view

Variants for DAZL Gene

Sequence variations from dbSNP and Humsavar for DAZL Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs121918346 other 16,598,169(-) ATGAA(A/C/G)CTGAG reference, missense
rs1000291375 -- 16,602,929(+) ATTAA(C/T)ACAGT intron-variant
rs1000316064 -- 16,592,219(+) TTTTG(-/A)TAGTT intron-variant
rs1000469581 -- 16,599,506(+) AAAAA(A/G)GGATT intron-variant
rs1000557643 -- 16,587,516(+) AAACG(-/AA)AGACT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DAZL Gene

Variant ID Type Subtype PubMed ID
dgv796n67 CNV loss 20364138
dgv798n67 CNV loss 20364138
dgv8247n54 CNV loss 21841781
esv22139 CNV loss 19812545
esv997976 CNV gain 20482838
nsv1072243 CNV deletion 25765185
nsv1112821 CNV deletion 24896259
nsv509814 OTHER sequence alteration 20534489
nsv822018 CNV loss 20364138
nsv822019 CNV loss 20364138
nsv822021 CNV loss 20364138
nsv822024 CNV loss 20364138
nsv822025 CNV loss 20364138
nsv834625 CNV gain 17160897

Variation tolerance for DAZL Gene

Residual Variation Intolerance Score: 48.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.82; 47.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAZL Gene

Human Gene Mutation Database (HGMD)
DAZL
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAZL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAZL Gene

Disorders for DAZL Gene

MalaCards: The human disease database

(8) MalaCards diseases for DAZL Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
azoospermia
  • spermatogenic failure
infertility
male infertility
  • infertility male
male reproductive system disease
  • genital diseases, male
y chromosome infertility
  • oligospermia
- elite association - COSMIC cancer census association via MalaCards
Search DAZL in MalaCards View complete list of genes associated with diseases

Relevant External Links for DAZL

Genetic Association Database (GAD)
DAZL
Human Genome Epidemiology (HuGE) Navigator
DAZL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAZL
genes like me logo Genes that share disorders with DAZL: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAZL Gene

Publications for DAZL Gene

  1. Phenotypic expression of partial AZFc deletions is independent of the variations in DAZL and BOULE in a Han population. (PMID: 19342699) Chen P. … Yang Y. (J. Androl. 2010) 3 22 46 64
  2. A386G polymorphism of the DAZL gene is not associated with idiopathic male infertility in North India. (PMID: 19881148) Singh K. … Raman R. (J Hum Reprod Sci 2009) 3 22 46 64
  3. [Autosomal DAZL single nucleotide polymorphisms not associated with male infertility in northeast China]. (PMID: 17918711) Wen X.H. … Wu W. (Zhonghua Nan Ke Xue 2007) 3 22 46 64
  4. A to G transitions at 260, 386 and 437 in DAZL gene are not associated with spermatogenic failure in Indian population. (PMID: 16573709) Thangaraj K. … Singh L. (Int. J. Androl. 2006) 3 22 46 64
  5. Association of DAZL haplotypes with spermatogenic failure in infertile men. (PMID: 16730721) Teng Y.N. … Kuo P.L. (Fertil. Steril. 2006) 3 22 46 64

Products for DAZL Gene

Sources for DAZL Gene

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