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DAZL Gene

protein-coding   GIFtS: 61
GCID: GC03M016603

Deleted In Azoospermia-Like


(Previous symbol: DAZLA)
  See DAZL-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deleted In Azoospermia-Like1 2     SPGY-like-autosomal2 3
DAZLA1 2 3     DAZ Homolog2 3
DAZH2 3 5     DAZ-Like Autosomal2 3
SPGYLA2 3 5     Germline Specific RNA Binding Protein2
Deleted In Azoospermia-Like 12 3     Spermatogenesis Gene On The Y-Like Autosomal2
DAZL12 3     

External Ids:    HGNC: 26851   Entrez Gene: 16182   Ensembl: ENSG000000923457   OMIM: 6014865   UniProtKB: Q929043   

Export aliases for DAZL gene to outside databases

Previous GC identifer: GC03M016557


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAZL Gene:
The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal
and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and
cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is
localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in
spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave
rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic
failure and infertility in males. Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Jun 2010)

GeneCards Summary for DAZL Gene:
DAZL (deleted in azoospermia-like) is a protein-coding gene. Diseases associated with DAZL include azoospermia, and spermatogenic failure. GO annotations related to this gene include RNA binding and translation activator activity. An important paralog of this gene is DAZ1.

UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
Function: RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central
role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and
thereby regulating the translation of key transcripts (By similarity)

Gene Wiki entry for DAZL Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAZL gene promoter:
         Max1   Pbx1a   Pax-6   MEF-2A   AREB6   FOXJ2 (long isoform)   aMEF-2   FOXJ2   RSRFC4   c-Myc   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAZL promoter sequence
   Search Chromatin IP Primers for DAZL

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAZL


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p24.3   Ensembl cytogenetic band:  3p24.3   HGNC cytogenetic band: 3p24

DAZL Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAZL gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03M016603:  view genomic region     (about GC identifiers)

Start:
16,628,299 bp from pter      End:
16,711,813 bp from pter
Size:
83,515 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904 (See protein sequence)
Recommended Name: Deleted in azoospermia-like  
Size: 295 amino acids; 33178 Da
Subunit: Homodimer and heterodimer. Multiple DAZL RRMs can bind to a single RNA containing multiple GUU triplets
(By similarity). Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2
Secondary accessions: O15396 Q5HYB4 Q92909
Alternative splicing: 2 isoforms:  Q92904-1   Q92904-2   

Explore the universe of human proteins at neXtProt for DAZL: NX_Q92904

Explore proteomics data for DAZL at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DAZL Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001177740.1  NP_001342.2  

    ENSEMBL proteins: 
     ENSP00000250863   ENSP00000382373   ENSP00000398109  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q92904

    ProtoNet protein and cluster: Q92904

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
    Domain: The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2
    Similarity: Belongs to the RRM DAZ family
    Similarity: Contains 1 DAZ-like domain
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with DAZL           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAZL_HUMAN, Q92904
    Function: RNA-binding protein, which is essential for gametogenesis in both males and females. Plays a central
    role during spermatogenesis. Acts by binding to the 3'-UTR of mRNA, specifically recognizing GUU triplets, and
    thereby regulating the translation of key transcripts (By similarity)

         Genatlas biochemistry entry for DAZL:
    deleted in azoospermia,autosomal-like,homolog of the mouse Dazla gene and the Drosophila boule (SPGY like
    autosomal),expressed only in male gonad

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding TAS8968755
    GO:0003730mRNA 3'-UTR binding IEA--
    GO:0005515protein binding IPI16001084
         
    Find genes that share ontologies with DAZL           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DAZL:
     Increased G2M DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dazl):
     endocrine/exocrine gland  reproductive system 

    Find genes that share phenotypes with DAZL           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dazltm1Hjc for DAZL

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DAZL
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAZL

    miRNA
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    miRTarBase miRNAs that target DAZL:
    hsa-mir-335-5p (MIRT016720)

    Block miRNA regulation of human, mouse, rat DAZL using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAZL (see all 22):
    hsa-miR-3938 hsa-miR-607 hsa-miR-3664-5p hsa-miR-4328 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidDAZL 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DAZL_HUMAN, Q92904: Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (By
    similarity). Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization
    from then onward (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus3

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--
    GO:0005844polysome IEA--

    Find genes that share ontologies with DAZL           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAZL About    
    See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control
    2Ovarian Infertility Genes
    Ovarian Infertility Genes


    Find genes that share SuperPaths with DAZL           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DAZL
        Translational Control

    1 BioSystems Pathway for DAZL
        Ovarian Infertility Genes



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DAZL
    Interactions:

        GeneGlobe Interaction Network for DAZL

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    Selected Interacting proteins for DAZL (Q929043 ENSP000003823734) via UniProtKB, MINT, STRING, and/or I2D (see all 21)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAZ1Q9NQZ33, ENSP000003845734I2D: score=3 STRING: ENSP00000384573
    DAZAP1Q96EP53, ENSP000002330784I2D: score=2 STRING: ENSP00000233078
    DCTN1Q142033, ENSP000003547914I2D: score=1 STRING: ENSP00000354791
    DCTN2Q135613, ENSP000004089104I2D: score=1 STRING: ENSP00000408910
    DYNC1I1O145763, ENSP000003201304I2D: score=1 STRING: ENSP00000320130
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007281germ cell development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0045836positive regulation of meiosis IEA--
    GO:0045948positive regulation of translational initiation IDA16001084

    Find genes that share ontologies with DAZL           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAZL

    2 Novoseek inferred chemical compound relationships for DAZL gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    vas-a 55.3 14 18088417 (8), 16228988 (2), 19573297 (1), 19602557 (1) (see all 5)
    adenylate 0.705 4 10819768 (1)



    Find genes that share compounds with DAZL           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DAZL gene (2 alternative transcripts): 
    NM_001190811.1  NM_001351.3  

    Unigene Cluster for DAZL:

    Deleted in azoospermia-like
    Hs.131179  [show with all ESTs]
    Unigene Representative Sequence: NM_001190811
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250863(uc003cba.3) ENST00000399444(uc003cbb.3) ENST00000454457

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DAZL (see all 22):
    hsa-miR-3938 hsa-miR-607 hsa-miR-3664-5p hsa-miR-4328 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-629
    SwitchGear 3'UTR luciferase reporter plasmidDAZL 3' UTR sequence
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    Additional mRNA sequence: 

    AK303026.1 AK310341.1 BC027595.2 BX648638.1 U65918.1 U66078.1 U66726.2 

    2 DOTS entries:

    DT.310516  DT.97804595 

    Selected AceView cDNA sequences (see all 52):

    NM_001351 AL705991 BX648638 BI464024 BI461267 BG723910 BG718804 BG210841 
    BX088864 BG771817 BG207704 U66078 CD300236 BF980336 BI464057 BI829533 
    BU569412 BI459106 BI460958 AL044707 BU853969 AA774538 CD557344 U66726 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAZL expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AATAAAAATA
    DAZL Expression
    About this image


    DAZL expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Gonad (Reproductive System)    fully expand to see all 9 entries
             Primordial Germ Cells Primitive Gonad
             Primordial germ-like cells
     
     Germ Cells (Reproductive System)    fully expand to see all 5 entries
             Primordial germ-like cells
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             XX Germ Cells Ovigerous Cord
             Ovarian tissue-dissociated cells (human)
     
     Testis (Reproductive System)    fully expand to see all 2 entries
             XY Germ Cells Testis Cord
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             ES-J1
    DAZL Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAZL Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.131179

    UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
    Tissue specificity: Testis specific

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DAZL gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dazl5 deleted in azoospermia-like   --   17 (25.86 cM) 50279394 
    chicken
    (Gallus gallus)
    Aves DAZL6
    Gallus gallus deleted in azoospermia-like (DAZL), ...
    65(a)
    1 → many
    2(34939869-35003900)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    65(a)
    1 → many
    6(34873464-34894381)
    African clawed frog
    (Xenopus laevis)
    Amphibia dazl2 DAZ-like protein 77.98(n)    AF017778.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dazl2 daz-like gene 73.65(n)   58039  AB018191.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bol6
    boule
    25(a)
    1 → many
    3L(9091208-9123452)
    worm
    (Caenorhabditis elegans)
    Secernentea daz-16
    Protein DAZ-1 (daz-1) mRNA, complete cds
    15(a)
    1 → many
    II(5456305-5458616) WBGene00000935


    ENSEMBL Gene Tree for DAZL (if available)
    TreeFam Gene Tree for DAZL (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAZL gene
    DAZ12  DAZ32  DAZ42  DAZ22  BOLL2  
    8 SIMAP similar genes for DAZL using alignment to 3 protein entries:     DAZL_HUMAN (see all proteins):
    DAZ2    DAZ3    DAZ4    DAZ1    BOLL    RBMY1A1
    RBFOX2    HNRNPA2B1

    Find genes that share paralogs with DAZL           About GenesLikeMe


    4 Pseudogenes.org Pseudogenes for DAZL
    PGOHUM00000233822 PGOHUM00000233854 PGOHUM00000234035 PGOHUM00000234068


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAZL (see all 565)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs18085181,2
    C,F,A,H--16563813(+) ACTAAA/CTGATG 2 -- int1102Minor allele frequency- C:0.31NS NA EA PA EU CA WA 6430
    rs610935751,2
    --16563879(+) ATTGGG/TAGTAC 2 -- int10--------
    rs1482689151,2
    --16563928(+) TTTTTG/TATTGC 2 -- int10--------
    rs751483541,2
    F--16563938(+) CATCCA/GTAAGA 2 -- int11Minor allele frequency- G:0.02WA 118
    rs170424401,2
    C,F--16563984(+) GCAACC/TGCAAT 2 -- int13Minor allele frequency- T:0.01NA 138
    rs1140936681,2
    F--16564005(+) AAAAGG/TTCTAG 2 -- int11Minor allele frequency- T:0.02WA 118
    rs1911524701,2
    --16564017(+) GATTAA/GGCCCA 2 -- int10--------
    rs105104531,2
    C,F,H--16564027(+) AAAGCG/ATACAG 2 -- int1104Minor allele frequency- A:0.09NS NA EA PA EU CA WA CSA 6304
    rs1503824991,2
    C--16564095(+) AGTCAG/TATGTG 2 -- int10--------
    rs23473121,2
    C,A,H--16564318(+) AAAAAG/CTTTAT 2 -- ut3111Minor allele frequency- C:0.25EA WA NA CSA 1843

    HapMap Linkage Disequilibrium report for DAZL (16628299 - 16711813 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DAZL (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv822025CNV Loss20364138
    nsv822019CNV Loss20364138
    dgv796n67CNV Loss20364138
    esv22139CNV Loss19812545
    nsv822018CNV Loss20364138
    nsv876586CNV Loss21882294
    nsv822021CNV Loss20364138
    nsv509814CNV Loss20534489
    nsv822024CNV Loss20364138
    dgv798n67CNV Loss20364138

    Human Gene Mutation Database (HGMD): DAZL
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DAZL
    DNA2.0 Custom Variant and Variant Library Synthesis for DAZL

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 601486    OMIM disorders: --

    6 diseases for DAZL:    
    About MalaCards
    azoospermia    spermatogenic failure    paraneoplastic syndromes    paraneoplastic neurologic disorders
    seminoma    infertility

    2 diseases from the University of Copenhagen DISEASES database for DAZL:
    Male infertility     Infertility

    Find genes that share disorders with DAZL           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DAZL gene (see all 16)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azoospermia 86.9 37 9783841 (2), 9294855 (2), 16123080 (2), 10527983 (1), 16979959 (1), 9239736 (1), 11058556 (1), 15490230 (1), 16573709 (1), 18366765 (1), 16425031 (1), 15139965 (1), 9143498 (1), 10340994 (1), 8968756 (1), 18620821 (1), 15879466 (1), 12200456 (1), 11956819 (1), 10857750 (1), 9588208 (1), 17268180 (1), 15081113 (1), 9882490 (1), 15806553 (1), 9486791 (1) (see top 4)
    infertility male 74.1 17 9294855 (3), 16573709 (2), 17918711 (2), 8968756 (2), 19881148 (2), 10819768 (1), 20300286 (1), 15705295 (1), 16123080 (1) (see top 4)
    paraneoplastic encephalomyelitis 70.6 1 8982120 (1)
    oligozoospermia 70.5 5 9294855 (2), 16573709 (1), 16123080 (1)
    infertility 52.4 5 20300286 (1), 11604102 (1), 17918711 (1), 14965334 (1)
    sterility male 51.7 3 9143498 (2), 16844779 (1)
    ovarian failure premature 50.8 2 10527983 (1)
    chromosome deletion 38.4 1 10601091 (1)
    paraneoplastic syndromes 27.4 1 10735272 (1)
    seminoma 18.4 7 11956819 (3), 16228988 (2)

    Genetic Association Database (GAD): DAZL
    Human Genome Epidemiology (HuGE) Navigator: DAZL (12 documents)

    Export disorders for DAZL gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for DAZL gene, integrated from 10 sources (see all 158):
    (articles sorted by number of sources associating them with DAZL)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association of a single-nucleotide polymorphism of the deleted-in- azoospermia-like gene with susceptibility to spermatogenic failure. (PubMed id 12414900)1, 2, 4 Teng Y.-N.... Kuo P.-L. (J. Clin. Endocrinol. Metab. 2002)
    2. The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. (PubMed id 8896558)1, 2, 3 Saxena R....Page D.C. (Nat. Genet. 1996)
    3. A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad. (PubMed id 8968755)1, 2, 9 Shan Z.... Vogt P.H. (Hum. Mol. Genet. 1996)
    4. Phenotypic expression of partial AZFc deletions is independent of the variations in DAZL and BOULE in a Han population. (PubMed id 19342699)1, 4, 9 Chen P....Yang Y. (J. Androl. 2010)
    5. A putative human male infertility gene DAZLA: genomic structure and methylation status. (PubMed id 9294855)1, 2, 9 Chai N.-N.... Yen P.H. (Mol. Hum. Reprod. 1997)
    6. The human autosomal gene DAZLA: testis specificity and a candidate for male infertility. (PubMed id 8968756)1, 2, 9 Yen P.H.... Salido E.C. (Hum. Mol. Genet. 1996)
    7. A to G transitions at 260, 386 and 437 in DAZL gene are not associated with spermatogenic failure in Indian population. (PubMed id 16573709)1, 4, 9 Thangaraj K....Singh L. (Int. J. Androl. 2006)
    8. Association of DAZL haplotypes with spermatogenic failure in infertile men. (PubMed id 16730721)1, 4, 9 Teng Y.N....Kuo P.L. (Fertil. Steril. 2006)
    9. Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PubMed id 10857750)1, 2, 9 Tsui S.... Yen P.H. (Genomics 2000)
    10. [Autosomal DAZL single nucleotide polymorphisms not associated with male infertility in northeast China]. (PubMed id 17918711)1, 4, 9 Wen X.H....Wu W. (Zhonghua Nan Ke Xue 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 1618 HGNC: 2685 AceView: DAZL Ensembl:ENSG00000092345 euGenes: HUgn1618
    ECgene: DAZL H-InvDB: DAZL

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DAZL Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DAZL gene:
    Search GeneIP for patents involving DAZL

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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