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Aliases & Descriptions for DAZL
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| DAZH 1, 2, 3, 5 | | DAZL1 1, 2, 3 | | DAZLA 2, 3 | | MGC26406 1, 2 | | SPGY-like-autosomal 3 | | SPGYLA 1, 2, 3, 5 |
| | | Descriptions |
|---|
| DAZ homolog 3 | | DAZ-like autosomal 3 | | Deleted in azoospermia-like 1 3 | | deleted in azoospermia-like 2 | | deleted in azoospermia-like autosomal 2 | | germline specific RNA binding protein 2 | | spermatogenesis gene on the Y-like autosomal 2 |
|
| | Search outside databases for aliases for DAZL genePrevious GC identifer: GC03M016557 |
Summaries for DAZL(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for DAZL: The DAZ (Deleted in AZoospermia) gene family encodes potential RNA binding proteins that are expressed in prenatal and postnatal germ cells of males and females. The protein encoded by this gene is localized to the nucleus and cytoplasm of fetal germ cells and to the cytoplasm of developing oocytes. In the testis, this protein is localized to the nucleus of spermatogonia but relocates to the cytoplasm during meiosis where it persists in spermatids and spermatozoa. Transposition and amplification of this autosomal gene during primate evolution gave rise to the DAZ gene cluster on the Y chromosome. Mutations in this gene have been linked to severe spermatogenic failure and infertility in males. [provided by RefSeq] UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904Function: RNA-binding protein, which is essential for gametogenesis. Plays a central role during spermatogenesis. May act by binding to the 3'-UTR of mRNA and thereby regulating the translation of key transcripts (By similarity)Gene Wiki entry for DAZL |
Genomic Location for DAZL
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the DAZL gene 
Entrez Gene cytogenetic band: 3p24.3 Ensembl cytogenetic band: 3p24.3 HGNC cytogenetic band: 3p24DAZL Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M016603:
(about GC identifiers)
Start:
|
16,603,303 bp from pter |
End:
|
16,622,010 bp from pter |
Size:
|
18,708 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000003.10 NT_022517.17
| Proteins for DAZL
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904 (See
protein sequence)Recommended Name: Deleted in azoospermia-like Size: 295 amino acids; 33178 Da
Subunit: Homodimer and heterodimer (By similarity). Forms a heterodimer with DAZ. Interacts with BOLL, DAZAP1 and DAZAP2. Interacts with PUM2
Subcellular location: Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantly cytoplasmic (By similarity). Nuclear in spermatogonia until near the end of the meiotic prophase and cytoplasmic localization from then onward (By similarity)
Secondary accessions: O15396 Q92909Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001342.2
ENSEMBL proteins: ENSP00000382373 ENSP00000250863
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: DAZL 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for DAZL: Assays for DAZL: | Protein
Domains/ Families for DAZL(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q92904
ProtoNet protein and cluster: Q92904 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904Domain: The DAZ-like domain mediates the interaction with DAZAP1 and DAZAP2Similarity: Belongs to the RRM DAZ familySimilarity: Contains 1 DAZ-like domainSimilarity: Contains 1 RRM (RNA recognition motif) domain | Gene Function for DAZL
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC027595
Applied Biosystems Silencer® siRNAs for DAZL
Sigma-Aldrich siRNA and siRNA Panels for DAZL  Sigma-Aldrich shRNA Panels and shRNA for DAZL  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001351                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001351                                  untagged cDNA clones in CMV expression vector (see all 2): BC027595 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001351
UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904Function: RNA-binding protein, which is essential for gametogenesis. Plays a central role during spermatogenesis. May act by binding to the 3'-UTR of mRNA and thereby regulating the translation of key transcripts (By similarity)Genatlas biochemistry entry for DAZL:deleted in azoospermia,autosomal-like,homolog of the mouse Dazla gene and the Drosophila boule (SPGY like autosomal),expressed only in male gonad2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Dazl):
4 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for DAZL
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for DAZL 
5/18 Interacting proteins for DAZL (ENSP000002508633) via UniProtKB, MINT, and/or STRING (see all 18
)About this table
5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6
): About this table
|
Drugs & Compounds for DAZL(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|  | Sigma-Aldrich Small Molecules for DAZL: Inhibitor |
Browse Tocris compounds for DAZL 1 Novoseek chemical compound relationship for DAZL gene
About this table
|
Transcripts for DAZL(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|                OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): BC027595
Sigma-Aldrich siRNA and siRNA Panels for DAZL  Sigma-Aldrich shRNA Panels and shRNA for DAZL  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001351 REFSEQ mRNAs for DAZL gene: NM_001351.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001351               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001351                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001351                                  untagged cDNA clones in CMV expression vector (see all 2): BC027595  Additional cDNA sequence: AK303026.1 AK310341.1 BC027595.2 BX648638.1 U65918.1 U66078.1 U66726.2 3 DOTS entries: DT.310516 DT.97804595 DT.40128670 24/52 AceView cDNA sequences (see all 52
):AL705991 NM_001351 BX648638 AW341566 U66726 CD644677 CD300236 BG207704 BF980336 BU569412 BI460958 BG723910 BC027595 AL044707 BQ441372 BI461267 BG771817 BI829533 BV199496 AA866027 BI463630 BG720712 BG210841 BU853969
highest scoring ESTs for DAZL:U66078 AA180386 AL705991 BC027595 BF979394 BG718013 BG718804 BG720145 BG720155 BG720712 Unigene Cluster for DAZL: Deleted in azoospermia-like Hs.131179 [show with all ESTs]Unigene Representative Sequence: BX648638
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000399444
ENST00000250863
|
Expression for DAZL
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| DAZL expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for DAZL
1 / 2 / 3 4 probe-sets matching DAZL gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AATAAAAATA
SOURCE GeneReport for Unigene cluster: Hs.131179
Expression variation in blood from EXPOLDB for DAZL UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904Tissue specificity: Testis specific |
Orthologs for DAZL
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DAZL gene from 5/8 species (see all 8
)
About this table Species with no ortholog for DAZL
ENSEMBL Gene Tree for DAZL | Paralogs for DAZL(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for DAZL gene
- DAZ12 DAZ32 DAZ42 DAZ22 BOLL2
|
SNPs/Variants for DAZL(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for DAZL (up to first 250kb)
|
Disorders & Mutations for DAZL
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 601486 UniProtKB/Swiss-Prot: DAZL_HUMAN, Q92904
Defects in DAZL may be a cause of infertility due to severe oligozoospermia (AZ) and non obstructive azoospermia10/16 Novoseek disease relationships for DAZL gene (see all 16
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| azoospermia |
87.77 |
37 |
9783841 (2), 9294855 (2), 16123080 (2), 10527983 (1) (see all 26) |
| infertility male |
72.78 |
13 |
9294855 (3), 16573709 (2), 8968756 (2), 17918711 (2) (see all 7) |
| paraneoplastic encephalomyelitis |
72.20 |
1 |
8982120 (1) |
| oligozoospermia |
72.04 |
5 |
9294855 (2), 16573709 (1), 16123080 (1) |
| sterility male |
54.04 |
3 |
9143498 (2), 16844779 (1) |
| ovarian failure premature |
53.43 |
2 |
10527983 (1) |
| infertility |
47.64 |
3 |
11604102 (1), 17918711 (1), 14965334 (1) |
| chromosome deletion |
40.45 |
1 |
10601091 (1) |
| paraneoplastic syndromes |
29.86 |
1 |
10735272 (1) |
| seminoma |
20.80 |
7 |
11956819 (3), 16228988 (2) |
About this table
Human Gene Mutation Database: DAZL Genetic Association Database: DAZL Human Genome Epidemiology Navigator: DAZL (11 documents)
|
Medical News for DAZL(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for DAZL (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/138 PubMed articles for DAZL gene (see all 138
):- Association of a single-nucleotide polymorphism of the deleted-in- azoospermia-like gene with susceptibility to spermatogenic failure. (PubMed id 12414900)3, 4, 6 Teng Y.-N.... Kuo P.-L. (2002)
- The DAZ gene cluster on the human Y chromosome arose from an autosomal gene that was transposed, repeatedly amplified and pruned. (PubMed id 8896558)2, 3, 4 Saxena R....Page D.C. (1996)
- A SPGY copy homologous to the mouse gene Dazla and the Drosophila gene boule is autosomal and expressed only in the human male gonad. (PubMed id 8968755)1, 3, 4 Shan Z.... Vogt P.H. (1996)
- A putative human male infertility gene DAZLA: genomic structure and methylation status. (PubMed id 9294855)1, 3, 4 Chai N.-N.... Yen P.H. (1997)
- The human autosomal gene DAZLA: testis specificity and a candidate for male infertility. (PubMed id 8968756)1, 3, 4 Yen P.H.... Salido E.C. (1996)
- Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PubMed id 10857750)1, 3, 4 Tsui S.... Yen P.H. (2000)
- Survey of the two polymorphisms in DAZL, an autosomal candidate for the azoospermic factor, in Japanese infertile men and implications for male infertility. (PubMed id 16123080)1, 3, 6 Yang X.J....Nakahori Y. (2005)
- A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. (PubMed id 11390979)1, 3, 4 Xu E.Y.... Reijo Pera R.A. (2001)
- No association of the A260G and A386G DAZL single nucleotide polymorphisms with male infertility in a Caucasian population. (PubMed id 15520024)1, 3, 6 Tschanter P....Gromoll J. (2004)
- Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)1, 3, 4 Moore F.L....Pera R.A. (2003)
|
Search for DAZL
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DAZL
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing DAZL
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DAZL(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for DAZL(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for DAZL:

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Incremental update: 13 Oct 2009
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