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DAZAP2 Gene

protein-coding   GIFtS: 54
GCID: GC12P051634

DAZ Associated Protein 2

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DAZ Associated Protein 21 2     Deleted In Azoospermia Associated Protein 22
Deleted In Azoospermia-Associated Protein 22 3     Proline-Rich Transcript In Brain2
PRTB2     Proline-Rich Transcript, Brain-Expressed Protein2
DAZ-Associated Protein 22     KIAA00583

External Ids:    HGNC: 26841   Entrez Gene: 98022   Ensembl: ENSG000001832837   OMIM: 6074315   UniProtKB: Q150383   

Export aliases for DAZAP2 gene to outside databases

Previous GC identifers: GC02U990100 GC12P051349 GC12P049918 GC12P048665


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAZAP2 Gene:
This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in
azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth
factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and
an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded
protein may function in various biological and pathological processes including spermatogenesis, cell signaling
and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and
pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for
this gene. (provided by RefSeq, Oct 2008)

GeneCards Summary for DAZAP2 Gene:
DAZAP2 (DAZ associated protein 2) is a protein-coding gene. Diseases associated with DAZAP2 include azoospermia, and myeloma. GO annotations related to this gene include WW domain binding.

Gene Wiki entry for DAZAP2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NC_018923.2  NT_029419.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAZAP2 gene promoter:
         GR   Sp1   AML1a   p53   Pax-6   FOXJ2 (long isoform)   c-Myb   FOXJ2   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAZAP2 promoter sequence
   Search Chromatin IP Primers for DAZAP2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAZAP2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q12   Ensembl cytogenetic band:  12q13.13   HGNC cytogenetic band: 12q13.13

DAZAP2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAZAP2 gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P051634:  view genomic region     (about GC identifiers)

Start:
51,632,076 bp from pter      End:
51,665,146 bp from pter
Size:
33,071 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DAZP2_HUMAN, Q15038 (See protein sequence)
Recommended Name: DAZ-associated protein 2  
Size: 168 amino acids; 17319 Da
Subunit: Interacts with SOX6 (By similarity). Interacts with DAZ and DAZL. Interacts with IL17RB. May interact
with FAM168B
Sequence caution: Sequence=BAA06545.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: A8K254 B4DDT5 B4E1G3 C9JA96 C9JP84 F8VU62
Alternative splicing: 5 isoforms:  Q15038-1   Q15038-2   Q15038-3   Q15038-4   Q15038-5   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DAZAP2: NX_Q15038

Post-translational modifications: 

  • Ubiquitinated by SMURF2, leading to proteasomal degradation1
  • Ubiquitination2 at Lys153
  • Modification sites at PhosphoSitePlus
  • REFSEQ proteins (6 alternative transcripts): 
    NP_001129736.1  NP_001129738.1  NP_001129739.1  NP_001129740.1  NP_001129741.1  NP_055579.1  

    ENSEMBL proteins: 
     ENSP00000394699   ENSP00000448051   ENSP00000398804   ENSP00000408251   ENSP00000446554  
     ENSP00000474597   ENSP00000404968   ENSP00000447842   ENSP00000412812  

    DAZAP2 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR022730 DAZ_assoc-2

    Graphical View of Domain Structure for InterPro Entry Q15038

    ProtoNet protein and cluster: Q15038

    1 Blocks protein domain: IPB000515 Binding-protein-dependent transport systems inner membrane component


    DAZAP2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI16189514
    GO:0050699WW domain binding IPI11342538
         
    DAZAP2 for ontologies           About GeneDecksing


    Phenotypes:
         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Dazap2):
     normal 

    DAZAP2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DAZAP2
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       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAZAP2

    miRNA
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    miRTarBase miRNAs that target DAZAP2:
    hsa-mir-302a-3p (MIRT006201), hsa-mir-375 (MIRT020036), hsa-mir-455-3p (MIRT037871), hsa-mir-193b-3p (MIRT016525), hsa-mir-100-5p (MIRT048456), hsa-mir-324-3p (MIRT042962), hsa-mir-7-5p (MIRT025951)

    Block miRNA regulation of human, mouse, rat DAZAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAZAP2 (see all 65):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-4307 hsa-miR-4328 hsa-miR-4272 hsa-miR-128 hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidDAZAP2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DAZAP2
    Predesigned siRNA for gene silencing in human, mouse, rat DAZAP2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 6): DAZAP2 (NM_001136267)
    Sino Biological Human cDNA Clone for DAZAP2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAZAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAZAP2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAZAP2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DAZP2_HUMAN, Q15038: Cytoplasm. Nucleus. Note=Predominantly nuclear in macrophages, stimulation of IL17RB with
    its ligand IL17E induces accumulation in the cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular2
    cytosol1
    lysosome1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    DAZAP2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAZAP2 About    
    See pathways by source

    SuperPathContained pathways About
    1Diurnally regulated genes with circadian orthologs
    Diurnally regulated genes with circadian orthologs


    1 BioSystems Pathway for DAZAP2
        Diurnally regulated genes with circadian orthologs



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DAZAP2
    Interactions:

        GeneGlobe Interaction Network for DAZAP2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DAZAP2 (Q150381, 2, 3 ENSP000004049684) via UniProtKB, MINT, STRING, and/or I2D (see all 95)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    EXD3Q9NX531, 2, 3, ENSP000003404744EBI-724310,EBI-750745 MINT-67896 I2D: score=2 I2D: score=2 STRING: ENSP00000340474
    POLIQ9UNA41, 2, 3, ENSP000002178004EBI-724310,EBI-741774 MINT-66469 I2D: score=4 STRING: ENSP00000217800
    RHOXF2Q9BQY41, 2, 3, ENSP000003604414EBI-724310,EBI-372094 MINT-67629 I2D: score=4 STRING: ENSP00000360441
    BATF2Q8N1L91, 2, 3, ENSP000003018874EBI-724310,EBI-742695 MINT-66287 I2D: score=3 STRING: ENSP00000301887
    ZFAND2BQ8WV991, 2, 3, ENSP000002895284EBI-724310,EBI-747823 MINT-67139 I2D: score=3 STRING: ENSP00000289528
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAZAP2 (DAZP2)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DAZAP2 gene (6 alternative transcripts): 
    NM_001136264.1  NM_001136266.1  NM_001136267.1  NM_001136268.1  NM_001136269.1  NM_014764.3  

    Unigene Cluster for DAZAP2:

    DAZ associated protein 2
    Hs.369761  [show with all ESTs]
    Unigene Representative Sequence: AK125855
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000412716(uc021qxy.1 uc010snc.2 uc001ryb.3 uc010sne.2 uc010snd.2)
    ENST00000552173 ENST00000549555 ENST00000439799 ENST00000425012(uc010snf.1)
    ENST00000551919 ENST00000549041 ENST00000549732 ENST00000604900 ENST00000436900
    ENST00000551534 ENST00000552459 ENST00000549497 ENST00000551313 ENST00000449723

    miRNA
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    Block miRNA regulation of human, mouse, rat DAZAP2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAZAP2 (see all 65):
    hsa-miR-607 hsa-miR-520e hsa-miR-302d hsa-miR-4307 hsa-miR-4328 hsa-miR-4272 hsa-miR-128 hsa-let-7a-2*
    SwitchGear 3'UTR luciferase reporter plasmidDAZAP2 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DAZAP2
    Predesigned siRNA for gene silencing in human, mouse, rat DAZAP2
    Clone
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    OriGene clones in human, mouse for DAZAP2 (see all 32)
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    GenScript: all cDNA clones in your preferred vector (see all 6): DAZAP2 (NM_001136267)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAZAP2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAZAP2
    Primer
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    OriGene qPCR primer pairs and template standards for DAZAP2
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DAZAP2
      QuantiTect SYBR Green Assays in human, mouse, rat DAZAP2
      QuantiFast Probe-based Assays in human, mouse, rat DAZAP2

    Additional mRNA sequence: 

    AK095963.1 AK125855.1 AK290119.1 AK293330.1 AK303828.1 AY430097.1 BC002334.2 BC007900.2 
    BX647278.1 D31767.1 

    Selected DOTS entries (see all 52):

    DT.95120036  DT.92344543  DT.454301  DT.91781467  DT.100881025  DT.100881017  DT.95120028  DT.100783065 
    DT.91802986  DT.87014327  DT.100881030  DT.91797300  DT.95120057  DT.100637838  DT.121124887  DT.100881010 
    DT.305912  DT.121124803  DT.205570  DT.120976765  DT.121124691  DT.97760188  DT.121125049  DT.95230545 

    Selected AceView cDNA sequences (see all 1283):

    BQ022067 N43920 AI264576 AA429968 BG430902 BF129023 AI250444 BX423228 
    AA771825 BQ690403 AA313277 BM927415 AA622027 BQ060697 CR598969 AI475369 
    AI471961 BM983499 CA392018 AW102956 BM759550 AA846644 AW661970 AI355407 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DAZAP2    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
    SP1:                                -                                 
    SP2:                                                                  
    SP3:                                -                 -     -         
    SP4:                                -     -     -                     
    SP5:                                                                  


    ECgene alternative splicing isoforms for DAZAP2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAZAP2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGATGTTTGA
    DAZAP2 Expression
    About this image

    DAZAP2 Protein expression data from MOPED1, PaxDb2 and MaxQB3 --

    SOURCE GeneReport for Unigene cluster: Hs.369761

    UniProtKB/Swiss-Prot: DAZP2_HUMAN, Q15038
    Tissue specificity: Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon
    and leukocytes. Down-regulated in multiple myeloma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAZAP2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DAZAP2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dazap21 , 5 DAZ associated protein 21, 5 93.85(n)1
    99.4(a)1
      15 (56.36 cM)5
    239941  NM_011873.21  NP_036003.21 
     1006156625 
    lizard
    (Anolis carolinensis)
    Reptilia DAZAP26
    DAZ associated protein 2
    58(a)
    1 ↔ 1
    2(67587374-67597819)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.295092 Xenopus laevis transcribed sequence with moderate similarity more 78.43(n)    CB199558.2 
    zebrafish
    (Danio rerio)
    Actinopterygii wufi04d042 wufi04d04 73.25(n)   327356  BC063229.1 


    ENSEMBL Gene Tree for DAZAP2 (if available)
    TreeFam Gene Tree for DAZAP2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAZAP2 gene

    DAZAP2 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DAZAP2
    PGOHUM00000240482


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAZAP2 (see all 207)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1140649741,2
    F--51464142(+) GAAACC/TTTCCC 6 -- us2k11Minor allele frequency- T:0.02WA 118
    rs107834251,2
    C,F,A,H--51464151(+) CCTGAC/TTACAT 6 -- us2k124Minor allele frequency- T:0.47NS EA NA WA CSA 2347
    rs1428655791,2
    C--51464171(+) GTAGGA/TGCCTC 6 -- us2k10--------
    rs1474259801,2
    --51464239(+) GTGTTC/GACTTT 6 -- us2k10--------
    rs757562091,2
    C,F--51464324(+) CTAGTG/ACCTGT 6 -- us2k11Minor allele frequency- A:0.02NA 120
    rs73974791,2
    C,F,H--51630614(+) CCTGTC/TCAAGA 6 -- us2k124Minor allele frequency- T:0.27NS EA NA WA CSA 2354
    rs733077601,2
    C,F--51630641(+) CTACTT/GTTTTT 6 -- us2k12Minor allele frequency- G:0.03WA 120
    rs1168492981,2
    C,F--51630682(+) GGCTGG/ATTCTG 6 -- us2k11Minor allele frequency- A:0.03NA 120
    rs581905561,2
    C,F--51630695(+) CTCCTG/AGCTCA 6 -- us2k13Minor allele frequency- A:0.12WA 122
    rs1167016311,2
    F--51630729(+) CCAAAG/CTGTTG 6 -- us2k11Minor allele frequency- C:0.03WA 118

    HapMap Linkage Disequilibrium report for DAZAP2 (51632076 - 51665146 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for DAZAP2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv704CNV Insertion18451855
    esv34039CNV Loss18971310

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DAZAP2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607431    OMIM disorders: --

    7 diseases for DAZAP2:    
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    azoospermia    myeloma    multiple myeloma    brachydactyly
    ataxia    prostatitis    malaria


    DAZAP2 for disorders           About GeneDecksing


    Export disorders for DAZAP2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAZAP2 gene, integrated from 10 sources (see all 34):
    (articles sorted by number of sources associating them with DAZAP2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PubMed id 10857750)1, 2, 3 Tsui S.... Yen P.H. (Genomics 2000)
    2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7584044)1, 2, 3 Nomura N.... Tabata S. (DNA Res. 1994)
    3. Smurf2 regulates IL17RB by proteasomal degradation of its novel binding partner DAZAP2. (PubMed id 22070932)1, 2 Popova A.... Gratchev A. (Immunobiology 2012)
    4. Molecular features and expression of DAZAP2 in human multiple myeloma. (PubMed id 17935665)1, 2 Shi Y.-W.... Hu W.-X. (Chin. Med. J. 2007)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Solubility-based genetic screen identifies RING finger protein 126 as an E3 ligase for activation-induced cytidine deaminase. (PubMed id 23277564)1 Delker R.K....Papavasiliou F.N. (Proc. Natl. Acad. Sci. U.S.A. 2013)
    8. The effects of promoter methylation on downregulation of DAZAP2 in multiple myeloma cell lines. (PubMed id 22792345)1 Luo S.Q....Hu W.X. (PLoS ONE 2012)
    9. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    10. Characterizing the neurite outgrowth inhibitory effect of Mani. (PubMed id 22771904)2 Mishra M.... Heese K. (FEBS Lett. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 9802 HGNC: 2684 AceView: DAZAP2 Ensembl:ENSG00000183283 euGenes: HUgn9802
    ECgene: DAZAP2 H-InvDB: DAZAP2

    (According to HUGE)
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    HUGE: KIAA0058

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DAZAP2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DAZAP2 gene:
    Search GeneIP for patents involving DAZAP2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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