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Aliases for DAZAP2 Gene

Aliases for DAZAP2 Gene

  • DAZ Associated Protein 2 2 3 5
  • Deleted In Azoospermia-Associated Protein 2 3 4
  • Proline-Rich Transcript, Brain-Expressed Protein 3
  • Deleted In Azoospermia Associated Protein 2 3
  • Proline-Rich Transcript In Brain 3
  • KIAA0058 4
  • PRTB 3

External Ids for DAZAP2 Gene

Previous GeneCards Identifiers for DAZAP2 Gene

  • GC02U990100
  • GC12P051349
  • GC12P049918
  • GC12P051634
  • GC12P048665

Summaries for DAZAP2 Gene

Entrez Gene Summary for DAZAP2 Gene

  • This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

GeneCards Summary for DAZAP2 Gene

DAZAP2 (DAZ Associated Protein 2) is a Protein Coding gene. Diseases associated with DAZAP2 include Multiple Myeloma and Myeloma. Among its related pathways are Diurnally regulated genes with circadian orthologs. GO annotations related to this gene include WW domain binding.

Gene Wiki entry for DAZAP2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAZAP2 Gene

Genomics for DAZAP2 Gene

Regulatory Elements for DAZAP2 Gene

Enhancers for DAZAP2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DAZAP2 on UCSC Golden Path with GeneCards custom track

Promoters for DAZAP2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DAZAP2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DAZAP2 Gene

Chromosome:
12
Start:
51,238,292 bp from pter
End:
51,271,362 bp from pter
Size:
33,071 bases
Orientation:
Plus strand

Genomic View for DAZAP2 Gene

Genes around DAZAP2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAZAP2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAZAP2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAZAP2 Gene

Proteins for DAZAP2 Gene

  • Protein details for DAZAP2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q15038-DAZP2_HUMAN
    Recommended name:
    DAZ-associated protein 2
    Protein Accession:
    Q15038
    Secondary Accessions:
    • A8K254
    • B4DDT5
    • B4E1G3
    • C9JA96
    • C9JP84
    • E9PB45
    • F8VU62

    Protein attributes for DAZAP2 Gene

    Size:
    168 amino acids
    Molecular mass:
    17319 Da
    Quaternary structure:
    • Interacts with SOX6 (By similarity). Interacts with DAZ and DAZL. Interacts with IL17RB. May interact with FAM168B.
    SequenceCaution:
    • Sequence=BAA06545.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for DAZAP2 Gene

neXtProt entry for DAZAP2 Gene

Proteomics data for DAZAP2 Gene at MOPED

Post-translational modifications for DAZAP2 Gene

No data available for DME Specific Peptides for DAZAP2 Gene

Domains & Families for DAZAP2 Gene

Protein Domains for DAZAP2 Gene

Suggested Antigen Peptide Sequences for DAZAP2 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DAZAP2: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DAZAP2 Gene

Function for DAZAP2 Gene

Gene Ontology (GO) - Molecular Function for DAZAP2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with DAZAP2: view

Phenotypes for DAZAP2 Gene

genes like me logo Genes that share phenotypes with DAZAP2: view

miRNA for DAZAP2 Gene

miRTarBase miRNAs that target DAZAP2

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DAZAP2 Gene

Localization for DAZAP2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAZAP2 Gene

Cytoplasm. Nucleus. Note=Predominantly nuclear in macrophages, stimulation of IL17RB with its ligand IL17E induces accumulation in the cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAZAP2 Gene COMPARTMENTS Subcellular localization image for DAZAP2 gene
Compartment Confidence
nucleus 5
extracellular 2
cytosol 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for DAZAP2 Gene

Pathways & Interactions for DAZAP2 Gene

genes like me logo Genes that share pathways with DAZAP2: view

Pathways by source for DAZAP2 Gene

1 BioSystems pathway for DAZAP2 Gene

Gene Ontology (GO) - Biological Process for DAZAP2 Gene

None

No data available for SIGNOR curated interactions for DAZAP2 Gene

Drugs & Compounds for DAZAP2 Gene

No Compound Related Data Available

Transcripts for DAZAP2 Gene

Unigene Clusters for DAZAP2 Gene

DAZ associated protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DAZAP2 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6
SP1: -
SP2:
SP3: - - -
SP4: - - -
SP5:

Relevant External Links for DAZAP2 Gene

GeneLoc Exon Structure for
DAZAP2
ECgene alternative splicing isoforms for
DAZAP2

Expression for DAZAP2 Gene

mRNA expression in normal human tissues for DAZAP2 Gene

mRNA differential expression in normal tissues according to GTEx for DAZAP2 Gene

This gene is overexpressed in Whole Blood (x5.1).

Protein differential expression in normal tissues from HIPED for DAZAP2 Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DAZAP2 Gene



SOURCE GeneReport for Unigene cluster for DAZAP2 Gene Hs.369761

mRNA Expression by UniProt/SwissProt for DAZAP2 Gene

Q15038-DAZP2_HUMAN
Tissue specificity: Widely expressed. Expressed in spleen, thymus, prostate, testis, ovary, small intestine, colon and leukocytes. Down-regulated in multiple myeloma.
genes like me logo Genes that share expression patterns with DAZAP2: view

Protein tissue co-expression partners for DAZAP2 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for DAZAP2 Gene

Orthologs for DAZAP2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DAZAP2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DAZAP2 35
  • 95.04 (n)
  • 100 (a)
DAZAP2 36
  • 67 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAZAP2 35
  • 95.04 (n)
  • 99.4 (a)
DAZAP2 36
  • 66 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dazap2 35
  • 93.85 (n)
  • 99.4 (a)
Dazap2 16
Dazap2 36
  • 66 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DAZAP2 35
  • 100 (n)
  • 100 (a)
DAZAP2 36
  • 100 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DAZAP2 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dazap2 35
  • 70.88 (n)
  • 75.3 (a)
MGC76067 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.29509 35
zebrafish
(Danio rerio)
Actinopterygii dazap2 35
  • 67.27 (n)
  • 63.25 (a)
wufi04d04 35
dazap2 36
  • 35 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.345 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.1706 36
  • 18 (a)
OneToOne
Species with no ortholog for DAZAP2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DAZAP2 Gene

ENSEMBL:
Gene Tree for DAZAP2 (if available)
TreeFam:
Gene Tree for DAZAP2 (if available)

Paralogs for DAZAP2 Gene

Pseudogenes.org Pseudogenes for DAZAP2 Gene

genes like me logo Genes that share paralogs with DAZAP2: view

No data available for Paralogs for DAZAP2 Gene

Variants for DAZAP2 Gene

Sequence variations from dbSNP and Humsavar for DAZAP2 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs57917280 - 51,241,042(+) CTGGC(G/T)CCACA intron-variant, reference, missense
rs14678 -- 51,242,743(+) TAATA(A/C)TGTAC intron-variant, utr-variant-3-prime
rs15839 -- 51,242,934(+) TTGCC(C/T)CACCC intron-variant, utr-variant-3-prime
rs12823299 -- 51,237,818(+) AAAAA(A/T)TTAAA upstream-variant-2KB
rs10876156 -- 51,243,385(+) AAAAA(C/T)TGGTT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for DAZAP2 Gene

Variant ID Type Subtype PubMed ID
esv34039 CNV Loss 18971310
nsv704 CNV Insertion 18451855

Variation tolerance for DAZAP2 Gene

Residual Variation Intolerance Score: 71.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.33; 7.40% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DAZAP2 Gene

Disorders for DAZAP2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for DAZAP2 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
multiple myeloma
  • plasma cell neoplasm
myeloma
  • multiple myeloma
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for DAZAP2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAZAP2
genes like me logo Genes that share disorders with DAZAP2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAZAP2 Gene

Publications for DAZAP2 Gene

  1. Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PMID: 10857750) Tsui S. … Yen P.H. (Genomics 2000) 2 3 4 67
  2. Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. (PMID: 7584044) Nomura N. … Tabata S. (DNA Res. 1994) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism. (PMID: 24722188) Corominas R. … Iakoucheva L.M. (Nat. Commun. 2014) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for DAZAP2 Gene

Sources for DAZAP2 Gene

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