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Aliases & Descriptions for DAZAP2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases KIAA0058 1 , 2 , 3 MGC14319 2 MGC766 2 PRTB 2
Descriptions DAZ associated protein 2 2 Deleted in azoospermia-associated protein 2 3 deleted in azoospermia associated protein 2 2 proline-rich transcript in brain 2 proline-rich transcript, brain-expressed protein 2
Search outside databases for aliases for DAZAP2 genePrevious GC identifers: GC02U990100 GC12P051349
Summaries for DAZAP2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for DAZAP2 : This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) andthe deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interactswith the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptoractivation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stabilityin splicing factor containing nuclear speckles. The encoded protein may function in variousbiological and pathological processes including spermatogenesis, cell signaling and transcriptionregulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesisof multiple myeloma. Multiple transcript variants encoding different isoforms have been found forthis gene. [provided by RefSeq] Gene Wiki entry for DAZAP2
Genomic Location for DAZAP2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the DAZAP2 gene Entrez Gene cytogenetic band: 12q12 Ensembl cytogenetic band: 12q13.13 HGNC cytogenetic band: 12q12 DAZAP2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 12 GeneLoc Exon Structure
GeneLoc location for GC12P049918:
(about GC identifiers )
Start:
49,918,877 bp from pter
End:
49,923,834 bp from pter
Size:
4,958 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000012.10 NT_029419.11 Proteins for DAZAP2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: DAZP2_HUMAN, Q15038 (See
protein sequence )Recommended Name: DAZ-associated protein 2 Size : 168 amino acids; 17319 Da
Subunit : Interacts with SOX6 (By similarity). Interacts with DAZ and DAZL
Post-translational modifications:
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (6 alternative transcripts):
NP_001129736.1 NP_001129738.1 NP_001129739.1 NP_001129740.1 NP_001129741.1 NP_055579.1 ENSEMBL proteins: ENSP00000331100 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells Antibodies for DAZAP2: Assays for DAZAP2:
Protein
Domains/ Families for DAZAP2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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ProtoNet protein and cluster: Q15038
1 Blocks protein family : IPB000515 Binding-protein-dependent transport systems inner membrane component Gene Function for DAZAP2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
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Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6 ): NM_001136266 Applied Biosystems Silencer ® siRNAs for DAZAP2 Sigma-Aldrich siRNA for DAZAP2 Sigma-Aldrich shRNA for DAZAP2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 6 ): NM_001136264                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 6 ): NM_001136264                                  untagged cDNA clones in CMV expression vector (see all 6 ): NM_001136264  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001136266
1 MGI mutant phenotype (inferred from 1 allele ) (MGI details for Dazap2) :2 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for DAZAP2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for DAZAP2 5/39 Interacting proteins for DAZAP2 (Q15038 1 , 2 ENSP00000331100 3 ) via UniProtKB, MINT, and/or STRING (see all 39
)About this table
Drugs & Compounds for DAZAP2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for DAZAP2
Transcripts for DAZAP2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
siRNAs from Applied Biosystems ,
Sigma-Aldrich ,
shRNA from
Sigma-Aldrich ,
OriGene ,
Tagged/untagged cDNA clones from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 6 ): NM_001136266 Sigma-Aldrich siRNA for DAZAP2 Sigma-Aldrich shRNA for DAZAP2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001136264 NM_001136266 NM_001136267 NM_001136268 NM_001136269 NM_014764
REFSEQ mRNAs for DAZAP2 gene (6 alternative transcripts): NM_001136264.1 NM_001136266.1 NM_001136267.1 NM_001136268.1 NM_001136269.1 NM_014764.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001136264 NM_001136266 NM_001136267 NM_001136269 NM_014764
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 6 ): NM_001136264                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 6 ): NM_001136264                                  untagged cDNA clones in CMV expression vector (see all 6 ): NM_001136264  
Additional cDNA sequence: AK095963.1 AK125855.1 AK290119.1 AK293330.1 AK303828.1 AY430097.1 BC002334.2 BC007900.2 BX647278.1 CR590843.1 CR594491.1 CR595995.1 CR598969.1 CR599409.1 CR602531.1 CR607711.1 CR609119.1 CR612770.1 CR614908.1 D31767.1
24/52 DOTS entries (see all 52
): DT.95120036 DT.92344543 DT.454301 DT.91781467 DT.100881025 DT.100881017 DT.95120028 DT.100783065 DT.87014327 DT.91802986 DT.100881030 DT.91797300 DT.95120057 DT.100637838 DT.305912 DT.121124887 DT.100881010 DT.205570 DT.121124803 DT.121124691 DT.120976765 DT.97760188 DT.121125049 DT.95230545
24/1283 AceView cDNA sequences (see all 1283
):AA367230 AA429968 AI475369 AA314671 BG545831 AI471961 BM970053 AA653092 AA346880 AI057417 AA973661 N43920 BF795191 BM710623 AA635666 AI250444 BM927415 AW518078 CR614908 AA737611 CF593495 BI711817 BM766493 BU169827
highest scoring ESTs for DAZAP2 :D31767 AA009590 AA025019 AA028897 AA028898 AA033735 AA035050 AA035291 AA035327 AA039878
Unigene Cluster for DAZAP2: DAZ associated protein 2 Hs.369761 [show with all ESTs ] Unigene Representative Sequence: AK125855 GeneLoc Exon Structure 5 Alternative Splicing Database (ASD) splice patterns (SP) for DAZAP2 ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 SP1 :           -             SP2 :                       SP3 :           -       -   -     SP4 :           -   -   -         SP5 :                      
About this scheme ECgene alternative splicing isoforms for DAZAP2 1 Ensembl transcript including schematic representation : ENST00000332845
Expression for DAZAP2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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DAZAP2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for DAZAP2 1 / 2 / 3
10 probe-sets matching DAZAP2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: TGATGTTTGASOURCE GeneReport for Unigene cluster: Hs.369761 Expression variation in blood from EXPOLDB for DAZAP2
UniProtKB/Swiss-Prot: DAZP2_HUMAN, Q15038 Tissue specificity : Widely expressed. Expressed in spleen, thymus, protate, testis, ovary, smallintestine, colon and leukocytes. Down-regulated in multiple myeloma
Orthologs for DAZAP2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for DAZAP2 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for DAZAP2 ENSEMBL Gene Tree for DAZAP2 Paralogs for DAZAP2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Pseudogenes 1 related pseudogene
SNPs/Variants for DAZAP2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for DAZAP2 (up to first 250kb)
Disorders & Mutations for DAZAP2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607431
Medical News for DAZAP2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for DAZAP2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/15 PubMed articles for DAZAP2 gene (see all 15
):
Search for DAZAP2
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DAZAP2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing DAZAP2
(According to HUGE )
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Specialized Databases showing DAZAP2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for DAZAP2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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