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Aliases & Descriptions for DAZAP1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Descriptions DAZ associated protein 1 2 Deleted in azoospermia-associated protein 1 3 deleted in azoospermia associated protein 1 2
Search outside databases for aliases for DAZAP1 genePrevious GC identifers: GC19P001465 GC19P001347 GC19P001359 GC19P001360
Summaries for DAZAP1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for DAZAP1 : In mammals, the Y chromosome directs the development of the testes and plays an important role inspermatogenesis. A high percentage of infertile men have deletions that map to regions of the Ychromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Ychromosome and is deleted in many azoospermic and severely oligospermic men. It is thought thatthe DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestralautosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes aRNA-binding protein with two RNP motifs that was originally identified by its interaction with theinfertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene.[provided by RefSeq] UniProtKB/Swiss-Prot: DAZP1_HUMAN, Q96EP5 Function : RNA-binding protein, which may be required during spermatogenesis
Gene Wiki entry for DAZAP1 (DAZ_associated_protein_1)
Genomic Location for DAZAP1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
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Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the DAZAP1 gene Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3 DAZAP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P001361:
(about GC identifiers )
Start:
1,358,584 bp from pter
End:
1,386,683 bp from pter
Size:
28,100 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000019.8 NT_011255.14 Proteins for DAZAP1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: DAZP1_HUMAN, Q96EP5 (See
protein sequence )Recommended Name: DAZ-associated protein 1 Size : 407 amino acids; 43383 Da
Subunit : Interacts with DAZ and DAZL
Subcellular location : Cytoplasm (By similarity). Nucleus (By similarity). Note=Predominantlycytoplasmic (By similarity). Nuclear at some stages of spermatozoides development. In midpachytenespermatocytes, it is localized in both the cytoplasm and the nuclei and is clearly excluded fromthe sex vesicles. In round spermatids, it localizes mainly in the nuclei, whereas in elongatedspermatids, it localizes to the cytoplasm (By similarity)
PDB structure from and Proteopedia : 2DGS (3D)
 2DH8 (3D)
 
Secondary accessions : Q96MJ3 Q9NRR9Alternative splicing : 2 isoforms : Q96EP5-1 Q96EP5-2
Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR1
View phosphorylation sites using PhosphoSite 2
REFSEQ proteins (2 alternative transcripts):
NP_061832.2 NP_733829.1 ENSEMBL proteins: ENSP00000337132 ENSP00000378904 ENSP00000233078 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: DAZAP1 3 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for DAZAP1: Assays for DAZAP1:
Protein
Domains/ Families for DAZAP1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q96EP5 ProtoNet protein and cluster: Q96EP5
1 Blocks protein family : IPB000504 RNA-binding region RNP-1 (RNA recognition motif) UniProtKB/Swiss-Prot: DAZP1_HUMAN, Q96EP5 Similarity : Contains 2 RRM (RNA recognition motif) domains
Gene Function for DAZAP1
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Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_018959 Applied Biosystems Silencer ® siRNAs for DAZAP1 Sigma-Aldrich siRNA for DAZAP1 Sigma-Aldrich shRNA for DAZAP1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_018959                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_018959                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_018959  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_018959 UniProtKB/Swiss-Prot: DAZP1_HUMAN, Q96EP5 Function : RNA-binding protein, which may be required during spermatogenesis
2 Gene Ontology (GO) molecular function terms (links to tree view) :
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Pathways & Interactions for DAZAP1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for DAZAP1 5 Interacting proteins for DAZAP1 (ENSP00000233078 3 ) via UniProtKB, MINT, and/or STRING About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
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Transcripts for DAZAP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
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ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_018959 Sigma-Aldrich siRNA for DAZAP1 Sigma-Aldrich shRNA for DAZAP1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_018959 NM_170711
REFSEQ mRNAs for DAZAP1 gene (2 alternative transcripts): NM_018959.2 NM_170711.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_018959 NM_170711
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_018959                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_018959                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_018959  
Additional cDNA sequence: AF181719.1 AK056850.1 AK124583.1 AK125032.1 AK128682.1 AL360261.1 BC012062.1 CR601549.1 CR608914.1 CR619052.1 CR626076.1
24/30 DOTS entries (see all 30
): DT.100690251 DT.100824328 DT.97859319 DT.97786432 DT.456067 DT.121495017 DT.91862508 DT.100824333 DT.100824337 DT.40113747 DT.40278462 DT.92034325 DT.100824334 DT.95201609 DT.121495005 DT.100824338 DT.40278443 DT.65287030 DT.92427967 DT.95201593 DT.95229276 DT.100824327 DT.100824331 DT.100824336
24/1397 AceView cDNA sequences (see all 1397
):BQ267530 AA427634 BF528347 AJ712364 BF726955 BQ052499 BG031724 BM989087 CD105342 BI225995 AK092894 BU173667 BU789785 BQ270471 BE882443 BM810095 BU075575 BM919393 BQ637034 AI675162 BI225840 AW276357 AI253589 CF129814
highest scoring ESTs for DAZAP1 :AA523424 AI951998 AI675162 AA046936 AA046956 AA278780 AA419178 AA626856 AA628585 AA643519
Unigene Cluster for DAZAP1: DAZ associated protein 1 Hs.222510 [show with all ESTs ] Unigene Representative Sequence: AK124583 GeneLoc Exon Structure 5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DAZAP1 (see all 10
) ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b · 12c ^ 13 ^ 14 ^ 15a · 15b · 15c SP1 :                                                   SP2 :         -   -   -                                       SP3 :         -   -   -                                       SP4 :                           -                         SP5 :         -   -   -               -                        
About this scheme ECgene alternative splicing isoforms for DAZAP1 3 Ensembl transcripts including schematic representations : ENST00000336761
ENST00000395533
ENST00000233078
Expression for DAZAP1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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DAZAP1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for DAZAP1 1 / 2 / 3
13 probe-sets matching DAZAP1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: AGCAAGCCCCSOURCE GeneReport for Unigene cluster: Hs.222510 UniProtKB/Swiss-Prot: DAZP1_HUMAN, Q96EP5 Tissue specificity : Mainly expressed in testis. Expressed to a lower level in thymus. Weakly or notexpressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas
Orthologs for DAZAP1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for DAZAP1 gene from 5/10 species (see all 10
)
About this table Species with no ortholog for DAZAP1 ENSEMBL Gene Tree for DAZAP1 Paralogs for DAZAP1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for DAZAP1 gene TARDBP 2
SNPs/Variants for DAZAP1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for DAZAP1 (up to first 250kb)
Disorders & Mutations for DAZAP1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
Novoseek , PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
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OMIM: 607430 1 Novoseek disease relationship for DAZAP1 gene
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Medical News for DAZAP1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for DAZAP1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
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10/15 PubMed articles for DAZAP1 gene (see all 15
): Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PubMed id 10857750) 2, 3, 4 Tsui S.... Yen P.H. (2000) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 3, 4 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 3, 4 Ota T....Sugano S. (2004) Characterization of the mouse Dazap1 gene encoding an RNA-binding protein that interacts with infertility factors DAZ and DAZL. (PubMed id 11604102) 1, 3 Dai T....Yen P.H. (2001) Expression patterns of the DAZ-associated protein DAZAP1 in rat and human ovaries. (PubMed id 16209998) 1, 3 Pan H.A....Kuo P.L. (2005) Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia. (PubMed id 15744350) 1, 3 Prima V.... Hunger S.P. (2005) DAZAP1 interacts via its RNA-recognition motifs with the C-termini of other RNA-binding proteins. (PubMed id 19285026) 1, 3 Yang H.T....Rousseau S. (2009) Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant. (PubMed id 18391021) 3 Goina E....Pagani F. (2008) Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348) 3 Barbe L....Andersson-Svahn H. (2008) ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. (PubMed id 17525332) 4 Matsuoka S.... Elledge S.J. (2007)
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Genome Databases showing DAZAP1
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and/or
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