External Ids for DAZ4 Gene
Previous GeneCards Identifiers for DAZ4 Gene
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Feb 2011]
GeneCards Summary for DAZ4 Gene
DAZ4 (Deleted In Azoospermia 4) is a Protein Coding gene. Diseases associated with DAZ4 include Azoospermia and Klinefelter's Syndrome. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is DAZL.
UniProtKB/Swiss-Prot for DAZ4 Gene
RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3-UTR of mRNAs and regulating their translation.