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DAZ4 Gene

protein-coding   GIFtS: 41
GCID: GC0YP026979

Deleted In Azoospermia 4

  See DAZ4-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deleted In Azoospermia 41 2
Deleted In Azoospermia Protein 42
pDP16802
pDP16812

External Ids:    HGNC: 159661   Entrez Gene: 571352   Ensembl: ENSG000002059167   UniProtKB: Q86SG33   

Export aliases for DAZ4 gene to outside databases

Previous GC identifers: GC0YU990030 GC0YM024120 GC0YM023614 GC0YP025389


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAZ4 Gene:
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor
(AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an
RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y
within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of
the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number
of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the
gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA
recognition motif (RRM) domain. This gene contains two copies of the 10.8 kb repeat. Alternatively spliced
transcript variants encoding different isoforms have been described. (provided by RefSeq, Feb 2011)

GeneCards Summary for DAZ4 Gene:
DAZ4 (deleted in azoospermia 4) is a protein-coding gene. Diseases associated with DAZ4 include persistent fetal circulation syndrome, and spermatogenic failure, y-linked, 2. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is DAZ1.

UniProtKB/Swiss-Prot: DAZ4_HUMAN, Q86SG3
Function: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of
mRNAs and regulating their translation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DAZ4 gene promoter:
         MEF-2A   POU2F1   p53   POU2F1a   aMEF-2   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DAZ4

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAZ4


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yq11.223   Ensembl cytogenetic band:  Yq11.23   HGNC cytogenetic band: Yq11

DAZ4 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAZ4 gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YP026979:  view genomic region     (about GC identifiers)

Start:
26,979,967 bp from pter      End:
27,053,187 bp from pter
Size:
73,221 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DAZ4_HUMAN, Q86SG3 (See protein sequence)
Recommended Name: Deleted in azoospermia protein 4  
Size: 579 amino acids; 64785 Da
Subunit: Forms a heterodimer with BOLL and DAZL. Interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and DZIP3
Miscellaneous: DAZ genes are prone to deletions but also to duplications. In a population of infertile men, DAZ
genes deletions are associated with oligozoospermia but an increased number of DAZ genes is not a significant
risk factor for spermatogenic failure
Miscellaneous: The DAZ proteins (DAZ, DAZ2, DAZ4 and DAZ4) are all encoded by a strongly repeated region of the Y
chromosome, in two clusters each comprising an inverted pair of DAZ genes. They are very similar, which gives
their indidual characterization difficult. Thus, most experiments do not discriminate between the different
members. One can therefore suppose that reported interactions with a DAZ protein involve all the 4 proteins
Secondary accessions: Q9NR88 Q9NR89
Alternative splicing: 2 isoforms:  Q86SG3-1   Q86SG3-2   

Explore the universe of human proteins at neXtProt for DAZ4: NX_Q86SG3

Explore proteomics data for DAZ4 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DAZ4 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001005375.1  NP_065153.1  

    ENSEMBL proteins: 
     ENSP00000371751   ENSP00000371733   ENSP00000389300   ENSP00000397895   ENSP00000401363  
     ENSP00000371869   ENSP00000383341   ENSP00000371727  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q86SG3

    ProtoNet protein and cluster: Q86SG3

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: DAZ4_HUMAN, Q86SG3
    Domain: The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2
    Similarity: Belongs to the RRM DAZ family
    Similarity: Contains 9 DAZ-like domains
    Similarity: Contains 2 RRM (RNA recognition motif) domains


    Find genes that share domains with DAZ4           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAZ4_HUMAN, Q86SG3
    Function: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of
    mRNAs and regulating their translation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
         
    Find genes that share ontologies with DAZ4           About GenesLikeMe


    Animal Models:
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DAZ4_HUMAN, Q86SG3: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide
    development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal
    gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DAZ4           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DAZ4
    Interactions:

        Search GeneGlobe Interaction Network for DAZ4

    5 Interacting proteins for DAZ4 (Q86SG33) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PUM2Q8TB723I2D: score=2 
    BOLLQ8N9W63I2D: score=1 
    DAZLQ929043I2D: score=1 
    DZIP1Q86YF93I2D: score=1 
    QKIQ96PU83I2D: score=1 
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with DAZ4           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAZ4

    1 Novoseek inferred chemical compound relationship for DAZ4 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 18.4 4 12449688 (2), 10202890 (1), 9880685 (1)



    Find genes that share compounds with DAZ4           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DAZ4 gene (2 alternative transcripts): 
    NM_001005375.2  NM_020420.3  

    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382314(uc022coy.1 uc010nxo.3) ENST00000382296 ENST00000449750
    ENST00000415508 ENST00000440066(uc022cox.1 uc004fwm.3) ENST00000382432(uc004fwo.3 uc004fwp.3 uc004fwr.3 uc022coz.1)
    ENST00000400494 ENST00000382290(uc004fwn.3 uc004fwq.3)
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate DAZ4 (see all 26):
    hsa-miR-4307 hsa-miR-1288 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-500a hsa-miR-548a-3p hsa-miR-144
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      QuantiFast Probe-based Assays in human, mouse, rat DAZ4

    12 AceView cDNA sequences:

    BC047480 AA128463 BG771514 AF248482 AA136143 BI561663 NM_004081 AL705202 
    U66077 BI562231 AA129915 AA136029 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAZ4 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DAZ4 Expression
    About this image

    DAZ4 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAZ4 Protein Expression

    UniProtKB/Swiss-Prot: DAZ4_HUMAN, Q86SG3
    Tissue specificity: Testis-specific. Expression restricted to premeiotic germ cells, particularly in spermatogonia
    (at protein level)

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DAZ4 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    Uncharacterized protein
    46(a)
    1 → many
    23(26194243-26213200)
    chicken
    (Gallus gallus)
    Aves DAZL6
    Gallus gallus deleted in azoospermia-like (DAZL), ...
    46(a)
    1 → many
    2(34939869-35003900)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    1 → many
    6(34873464-34894381)
    zebrafish
    (Danio rerio)
    Actinopterygii dazl6
    deleted in azoospermia-like
    36(a)
    1 → many
    19(20871401-20886168) ENSDARG00000036214
    fruit fly
    (Drosophila melanogaster)
    Insecta bol6
    boule
    23(a)
    1 → many
    3L(9091208-9123452)
    worm
    (Caenorhabditis elegans)
    Secernentea daz-16
    Protein DAZ-1 (daz-1) mRNA, complete cds
    16(a)
    1 → many
    II(5456305-5458616) WBGene00000935


    ENSEMBL Gene Tree for DAZ4 (if available)
    TreeFam Gene Tree for DAZ4 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAZ4 gene
    DAZ11 2  DAZL2  DAZ32  DAZ22  BOLL2  
    11 SIMAP similar genes for DAZ4 using alignment to 4 protein entries:     DAZ4_HUMAN (see all proteins):
    DAZ    DAZ1    DAZ3    DAZ2    DAZL    BOLL
    DKFZp666C074    RBMY1A1    RBMX    MSI2    CIRBP

    Find genes that share paralogs with DAZ4           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    DAZ4_HUMAN, Q86SG3: The number as well as the precise structure of the DAZ proteins probably differs within the
    population


    Selected SNPs for DAZ4 (see all 28)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr Y posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs561496751,2
    C--26983097(+) GACACA/GCCACA 2 -- int10--------
    rs763516621,2
    C--26996147(+) ATATCC/TAATCA 2 -- int10--------
    rs748486231,2
    C--27007791(+) AGCCAC/TAACAT 2 -- int10--------
    rs561632431,2
    C--27028490(+) TTATAC/TCAATG 2 -- int10--------
    rs560391101,2
    C--27035220(+) CCAATA/GATTAT 2 -- int10--------
    rs1125334401,2
    C--27039006(+) TGGAAC/TGAAGT 2 -- int10--------
    rs2020574131,2
    ----27031885(+) TACAAA/CTACAC 2 -- int10--------
    rs3684938041,2
    ----26996143(+) AGGGAG/TATCTA 2 -- int10--------
    rs352637171,2
    ----27022297(+) TTTTTA/TAAAAT 2 -- int10--------
    rs2003779941,2
    ----27039001(+) TTTTCC/TGGAAT 2 -- int10--------

    HapMap Linkage Disequilibrium report for DAZ4 (26979967 - 27053187 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DAZ4 (see all 15):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv10034CNV Loss18304495
    nsv469766CNV Loss16826518
    nsv471613CNV Gain+Loss15918152
    nsv442825CNV CNV18776908
    nsv442826CNV CNV18776908
    essv10843CNV CNV17122850
    dgv2506e1CNV Complex17122850
    dgv2505e1CNV Complex17122850
    dgv2504e1CNV Complex17122850
    nsv515230CNV Complex21397061

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    UniProtKB/Swiss-Prot: DAZ4_HUMAN, Q86SG3
  • Spermatogenic failure Y-linked 2 (SPGFY2) [MIM:415000]: A disorder resulting in the absence (azoospermia)
    or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. Note=The disease may be caused
    by mutations affecting the gene represented in this entry. AZFc deletions in the Yq11.23 region including the DAZ
    genes are the most common known genetic cause of human male infertility

  • 5 diseases for DAZ4:    
    About MalaCards
    persistent fetal circulation syndrome    spermatogenic failure, y-linked, 2    azoospermia    oligospermia
    mixed gonadal dysgenesis


    Find genes that share disorders with DAZ4           About GenesLikeMe

    6 Novoseek inferred disease relationships for DAZ4 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azoospermia 91.2 30 10202890 (2), 15081113 (2), 10527983 (1), 14666162 (1) (see all 22)
    klinefelters syndrome 67.8 3 10202890 (3)
    infertility male 60.7 1 11604102 (1)
    karyotype abnormal 56.2 1 9880685 (1)
    oligozoospermia 56.1 1 12200456 (1)
    infertility 50.5 3 9880685 (1), 17526644 (1), 9490306 (1)

    Genetic Association Database (GAD): DAZ4
    Human Genome Epidemiology (HuGE) Navigator: DAZ4 (1 document)

    Export disorders for DAZ4 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAZ4 gene, integrated from 10 sources (see all 56):
    (articles sorted by number of sources associating them with DAZ4)
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    1. Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. (PubMed id 10936047)1, 2, 3 Saxena R.... Page D.C. (Genomics 2000)
    2. Partial DAZ deletions in a family with five infertile brothers. (PubMed id 12801575)1, 2, 9 Gianotten J....van der Veen F. (Fertil. Steril. 2003)
    3. Polymorphic expression of DAZ proteins in the human testis. (PubMed id 19223287)1, 2 Kim B.... Paick J.S. (Hum. Reprod. 2009)
    4. [Study on DAZ gene copy deletion in severe oligozoospermia sperm donor for ICSI]. (PubMed id 16963411)1, 4 A Z.C....Lin L. (Yi Chuan 2006)
    5. A large AZFc deletion removes DAZ3/DAZ4 and nearby genes from men in Y haplogroup N. (PubMed id 14639527)1, 3 Fernandes S....Vogt P.H. (Am. J. Hum. Genet. 2004)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)1, 2 Moore F.L.... Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    8. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (Nature 2003)
    9. Polymorphic DAZ gene family in polymorphic structure of AZFc locus: artwork or functional for human spermatogenesis? (PubMed id 12752250)1, 2 Vogt P.H. and Fernandes S. (APMIS 2003)
    10. A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. (PubMed id 11390979)1, 2 Xu E.Y.... Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57135 HGNC: 15966 AceView: DAZ.2 Ensembl:ENSG00000205916 euGenes: HUgn57135
    ECgene: DAZ4 H-InvDB: DAZ4

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DAZ4 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DAZ4 gene:
    Search GeneIP for patents involving DAZ4

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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