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Aliases &
Descriptions
for DAZ3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| MGC126441 2 | | OTTHUMP00000042590 2 | | pDP1679 2 |
| | | Descriptions |
|---|
| deleted in azoospermia 3 2 |
|
| |
Search outside databases for aliases for DAZ3 genePrevious GC identifers: GC0YP026134 GC0YM026055 GC0YM024523 GC0YM025756 GC0YP024213 GC0YP023705 GC0YP023707 GC0YP023709 GC0YP023711 |
Summaries
for DAZ3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for DAZ3:
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal
azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in
spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four
copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes
is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains
a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is
variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene
also contains a 10.8 kb region that may be amplified; this region includes five exons that encode
an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat.
[provided by RefSeq]
UniProtKB/Swiss-Prot: DAZ3_HUMAN, Q9NR90Function: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding
to the 3'-UTR of mRNAs and regulating their translationGene Wiki entry for DAZ3 |
Genomic Location
for DAZ3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the DAZ3 gene 
Entrez Gene cytogenetic band: Yq11.223 Ensembl cytogenetic band: Yq11.223 HGNC cytogenetic band: Yq11.223DAZ3 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome Y GeneLoc Exon Structure GeneLoc location for GC0YM025319:
(about GC identifiers)
Start:
|
25,318,604 bp from pter |
End:
|
25,369,014 bp from pter |
Size:
|
50,411 bases |
Orientation:
|
minus strand |
| Proteins
for DAZ3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: DAZ3_HUMAN, Q9NR90 (See
protein sequence)Recommended Name: Deleted in azoospermia protein 3 Size: 486 amino acids; 54989 Da
Subunit: Forms a heterodimer with BOLL and DAZL. Interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and
DZIP3
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of
spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide
differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the
cytoplasm during male meiosis
Miscellaneous: The DAZ proteins (DAZ, DAZ2, DAZ4 and DAZ4) are all encoded by a strongly repeated
region of the Y chromosome, in two clusters each comprising an inverted pair of DAZ genes. They
are very similar, which gives their indidual characterization difficult. Thus, most experiments do
not discriminate between the different members. One can therefore suppose that reported
interactions with a DAZ protein involve all the 4 proteinsREFSEQ proteins: NP_065097.2
ENSEMBL proteins: ENSP00000383073 ENSP00000371793 ENSP00000371802 ENSP00000302355 ENSP00000324965 ENSP00000307537
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
Antibodies for DAZ3:
Assays for DAZ3: | Protein
Domains/
Families
for DAZ3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9NR90
ProtoNet protein and cluster: Q9NR90 1 Blocks protein family: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)
UniProtKB/Swiss-Prot: DAZ3_HUMAN, Q9NR90Domain: The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2Similarity: Belongs to the RRM DAZ familySimilarity: Contains 12 DAZ-like domainsSimilarity: Contains 1 RRM (RNA recognition motif) domain | Gene Function
for DAZ3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020364
 Applied Biosystems Silencer® siRNAs for DAZ3
 Sigma-Aldrich siRNA for DAZ3
Sigma-Aldrich shRNA for DAZ3
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_020364
Myc/DDK tagged cDNA clone in CMV expression vector: NM_020364
untagged cDNA clone in CMV expression vector: NM_020364
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_020364
UniProtKB/Swiss-Prot: DAZ3_HUMAN, Q9NR90Function: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding
to the 3'-UTR of mRNAs and regulating their translation | Pathways & Interactions
for DAZ3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
-- |
Drugs & Compounds
for DAZ3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for DAZ3
|
Transcripts
for DAZ3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vector: NM_020364
Sigma-Aldrich siRNA for DAZ3
Sigma-Aldrich shRNA for DAZ3
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_020364 REFSEQ mRNAs for DAZ3 gene: NM_020364.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_020364
OriGene GFP tagged cDNA clone in CMV expression vector: NM_020364
Myc/DDK tagged cDNA clone in CMV expression vector: NM_020364
untagged cDNA clone in CMV expression vector: NM_020364
16 AceView cDNA sequences:U66077 BI561663 AA128463 AA136143 AF414184 AL705202 BG771514 NM_020364 BI562231 AF248481 AA129915 AF248480 BC036648 AA136029 NM_020363 BG724038
 highest scoring ESTs for DAZ3:AF248481 NM_020364
GeneLoc Exon Structure
6 Ensembl transcripts including schematic representations: ENST00000400212
ENST00000382356
ENST00000382365
ENST00000306944
ENST00000315357
ENST00000306737
|
Expression
for DAZ3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| DAZ3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for DAZ3
1 / 2 / 3 13 probe-sets matching DAZ3 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
UniProtKB/Swiss-Prot: DAZ3_HUMAN, Q9NR90Tissue specificity: Testis specific |
Orthologs
for DAZ3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DAZ3 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
chimpanzee
(Pan troglodytes) |
DAZ31 |
-- |
deleted in azoospermia 3 |
96.73(n)
93.38(a) |
738636 XM_001138461.1 XP_001138461.1 |
About this table Species with no ortholog for DAZ3
ENSEMBL Gene Tree for DAZ3 | Paralogs
for DAZ3(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for DAZ3 gene
- DAZL2 DAZ12 DAZ42 DAZ22 BOLL2
|
SNPs/Variants
for DAZ3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
| UniProtKB/Swiss-Prot: DAZ3_HUMAN, Q9NR90Polymorphism: The number as well as the precise structure of the DAZ proteins probably differs
within the population |
Disorders & Mutations
for DAZ3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 400027
UniProtKB/Swiss-Prot: DAZ3_HUMAN, Q9NR90
AZFc deletions in the Yq11.23 region, including the DAZ genes, are a cause of azoospermia
or oligospermia. They lead to male infertility due to impaired spermatogenesis and are found 2-10%
of azoospermic or severe oligospermic malesHuman Genome Epidemiology Navigator: DAZ3 (1 document)
|
Medical News
for DAZ3(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications
for DAZ3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/28 PubMed articles for DAZ3 gene (see all 28
):- Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. (PubMed id 10936047)2, 3, 4 Saxena R.... Page D.C. (2000)
- The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)3, 4 Skaletsky H....Page D.C. (2003)
- Polymorphic DAZ gene family in polymorphic structure of AZFc locus: artwork or functional for human spermatogenesis? (PubMed id 12752250)3, 4 Vogt P.H. and Fernandes S. (2003)
- Partial DAZ deletions in a family with five infertile brothers. (PubMed id 12801575)3, 4 Gianotten J....van der Veen F. (2003)
- Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)3, 4 Moore F.L....Pera R.A. (2003)
- A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. (PubMed id 11390979)3, 4 Xu E.Y.... Reijo Pera R.A. (2001)
- Male infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome. (PubMed id 11095434)3, 4 Moro E.... Foresta C. (2000)
- Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PubMed id 10857750)3, 4 Tsui S.... Yen P.H. (2000)
- In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein. (PubMed id 10903443)3, 4 Ruggiu M. and Cooke H.J. (2000)
- DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice. (PubMed id 11058556)3, 4 Reijo R.A.... Page D.C. (2000)
|
Search for DAZ3
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DAZ3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing DAZ3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DAZ3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| About This Section
| --
| Services
for DAZ3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for DAZ3:
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