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Aliases for DAZ3 Gene

Aliases for DAZ3 Gene

  • Deleted In Azoospermia 3 2 3 5
  • PDP1679 3

External Ids for DAZ3 Gene

Previous GeneCards Identifiers for DAZ3 Gene

  • GC0YP026134
  • GC0YM026055
  • GC0YM024523
  • GC0YM025756
  • GC0YP024213
  • GC0YP023705
  • GC0YP023707
  • GC0YP023709
  • GC0YP023711
  • GC0YM025319
  • GC0YM026909

Summaries for DAZ3 Gene

Entrez Gene Summary for DAZ3 Gene

  • This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. [provided by RefSeq, Jul 2008]

GeneCards Summary for DAZ3 Gene

DAZ3 (Deleted In Azoospermia 3) is a Protein Coding gene. Diseases associated with DAZ3 include Azoospermia and Partial Deletion Of Y. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is DAZL.

UniProtKB/Swiss-Prot for DAZ3 Gene

  • RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3-UTR of mRNAs and regulating their translation.

Gene Wiki entry for DAZ3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAZ3 Gene

Genomics for DAZ3 Gene

Regulatory Elements for DAZ3 Gene

Genomic Location for DAZ3 Gene

24,763,069 bp from pter
24,813,505 bp from pter
50,437 bases
Minus strand

Genomic View for DAZ3 Gene

Genes around DAZ3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAZ3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAZ3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAZ3 Gene

Proteins for DAZ3 Gene

  • Protein details for DAZ3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Deleted in azoospermia protein 3
    Protein Accession:
    Secondary Accessions:
    • Q2KHN7

    Protein attributes for DAZ3 Gene

    486 amino acids
    Molecular mass:
    54989 Da
    Quaternary structure:
    • Forms a heterodimer with BOLL and DAZL. Interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and DZIP3.
    • The DAZ proteins (DAZ, DAZ2, DAZ4 and DAZ4) are all encoded by a strongly repeated region of the Y chromosome, in two clusters each comprising an inverted pair of DAZ genes. They are very similar, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a DAZ protein involve all the 4 proteins.

    Alternative splice isoforms for DAZ3 Gene


neXtProt entry for DAZ3 Gene

Proteomics data for DAZ3 Gene at MOPED

Post-translational modifications for DAZ3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAZ3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Abcam antibodies for DAZ3

No data available for DME Specific Peptides for DAZ3 Gene

Domains & Families for DAZ3 Gene

Gene Families for DAZ3 Gene

Protein Domains for DAZ3 Gene

Suggested Antigen Peptide Sequences for DAZ3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2.
  • Belongs to the RRM DAZ family.
  • The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2.
  • Contains 12 DAZ-like domains.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRM DAZ family.
genes like me logo Genes that share domains with DAZ3: view

Function for DAZ3 Gene

Molecular function for DAZ3 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3-UTR of mRNAs and regulating their translation.
genes like me logo Genes that share phenotypes with DAZ3: view

Human Phenotype Ontology for DAZ3 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DAZ3 Gene

Localization for DAZ3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAZ3 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.

Subcellular locations from

Jensen Localization Image for DAZ3 Gene COMPARTMENTS Subcellular localization image for DAZ3 gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DAZ3 Gene

Pathways & Interactions for DAZ3 Gene

SuperPathways for DAZ3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DAZ3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with DAZ3: view

No data available for Pathways by source and SIGNOR curated interactions for DAZ3 Gene

Drugs & Compounds for DAZ3 Gene

No Compound Related Data Available

Transcripts for DAZ3 Gene

mRNA/cDNA for DAZ3 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for DAZ3 Gene

No ASD Table

Relevant External Links for DAZ3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DAZ3 Gene

mRNA expression in normal human tissues for DAZ3 Gene

mRNA differential expression in normal tissues according to GTEx for DAZ3 Gene

This gene is overexpressed in Testis (x24.9), Skin - Not Sun Exposed (Suprapubic) (x9.8), Stomach (x8.2), and Skin - Sun Exposed (Lower leg) (x7.2).

mRNA Expression by UniProt/SwissProt for DAZ3 Gene

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with DAZ3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DAZ3 Gene

Orthologs for DAZ3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DAZ3 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DAZ3 35
  • 96.73 (n)
  • 93.38 (a)
DAZ 36
  • 73 (a)
DAZ 36
  • 93 (a)
DAZ 36
  • 93 (a)
DAZ 36
  • 47 (a)
(Bos Taurus)
Mammalia DAZL 36
  • 57 (a)
(Canis familiaris)
Mammalia -- 36
  • 46 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 54 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
(Gallus gallus)
Aves DAZL 36
  • 47 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
(Danio rerio)
Actinopterygii dazl 36
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta bol 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea daz-1 36
  • 15 (a)
Species with no ortholog for DAZ3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DAZ3 Gene

Gene Tree for DAZ3 (if available)
Gene Tree for DAZ3 (if available)

Paralogs for DAZ3 Gene

Paralogs for DAZ3 Gene

(8) SIMAP similar genes for DAZ3 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DAZ3: view

Variants for DAZ3 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for DAZ3 Gene

The number as well as the precise structure of the DAZ proteins probably differs within the population.

Sequence variations from dbSNP and Humsavar for DAZ3 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs1152100 -- 24,804,923(-) TGACC(C/T)GTGTA intron-variant
rs1273625 -- 24,776,050(-) gagct(A/G)tagac intron-variant
rs36183266 -- 24,777,531(+) CCACA(A/C/G)AGATA intron-variant
rs56067595 -- 24,775,807(+) TCGGG(C/T)TAACA intron-variant
rs56282077 -- 24,796,169(+) ATAAT(C/T)CTGAA intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DAZ3 Gene

Variant ID Type Subtype PubMed ID
dgv2505e1 CNV Complex 17122850
dgv2506e1 CNV Complex 17122850
nsv10034 CNV Loss 18304495
essv10843 CNV CNV 17122850
dgv2507e1 CNV Complex 17122850
nsv442825 CNV CNV 18776908
dgv2509e1 CNV Complex 17122850
dgv2510e1 CNV Complex 17122850
nsv515230 CNV Complex 21397061
dgv2511e1 CNV Complex 17122850
dgv2512e1 CNV Complex 17122850
nsv469766 CNV Loss 16826518
nsv471613 CNV Gain+Loss 15918152
nsv442826 CNV CNV 18776908

No data available for Variation tolerance and Relevant External Links for DAZ3 Gene

Disorders for DAZ3 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DAZ3 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • spermatogenic failure
partial deletion of y
  • partial deletion of chromosome y
male infertility
  • infertility male
spermatogenic failure, y-linked, 2
  • spermatogenic failure y-linked 2
- elite association - COSMIC cancer census association via MalaCards
Search DAZ3 in MalaCards View complete list of genes associated with diseases


  • Spermatogenic failure Y-linked 2 (SPGFY2) [MIM:415000]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. {ECO:0000269 PubMed:11095434, ECO:0000269 PubMed:12801575}. Note=The disease may be caused by mutations affecting the gene represented in this entry. AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility.

Relevant External Links for DAZ3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DAZ3: view

No data available for Genatlas for DAZ3 Gene

Publications for DAZ3 Gene

  1. Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. (PMID: 10936047) Saxena R. … Page D.C. (Genomics 2000) 2 3 4 67
  2. Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility. (PMID: 26232607) Zhang Y. … Yang X. (Gene 2015) 3
  3. Polymorphic expression of DAZ proteins in the human testis. (PMID: 19223287) Kim B. … Paick J.S. (Hum. Reprod. 2009) 3
  4. AZFc partial deletions in Chilean men with severe spermatogenic failure. (PMID: 17416365) Lardone M.C. … Castro A. (Fertil. Steril. 2007) 3
  5. [Study on DAZ gene copy deletion in severe oligozoospermia sperm donor for ICSI]. (PMID: 16963411) A Z.C. … Lin L. (Yi Chuan 2006) 3

Products for DAZ3 Gene

Sources for DAZ3 Gene