Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DAZ3 Gene

protein-coding   GIFtS: 43
GCID: GC0YM026909

Deleted In Azoospermia 3

  See DAZ3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Deleted In Azoospermia 31 2
Deleted In Azoospermia Protein 32
pDP16792

External Ids:    HGNC: 159651   Entrez Gene: 570542   Ensembl: ENSG000001871917   OMIM: 4000275   UniProtKB: Q9NR903   

Export aliases for DAZ3 gene to outside databases

Previous GC identifers: GC0YP026134 GC0YM026055 GC0YM024523 GC0YM025756 GC0YP024213 GC0YP023705 GC0YP023707 GC0YP023709 GC0YP023711 GC0YM025319


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DAZ3 Gene:
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor
(AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an
RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y
within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of
the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number
of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the
gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA
recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. (provided by RefSeq, Jul 2008)

GeneCards Summary for DAZ3 Gene:
DAZ3 (deleted in azoospermia 3) is a protein-coding gene. Diseases associated with DAZ3 include persistent fetal circulation syndrome, and spermatogenic failure, y-linked, 2. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is DAZ1.

UniProtKB/Swiss-Prot: DAZ3_HUMAN, Q9NR90
Function: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of
mRNAs and regulating their translation

Gene Wiki entry for DAZ3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the DAZ3 gene promoter:
         Max1   p53   POU6F1 (c2)   AREB6   MEF-2A   POU2F1   POU2F1a   aMEF-2   RSRFC4   c-Myc   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DAZ3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAZ3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yq11.223   Ensembl cytogenetic band:  Yq11.23   HGNC cytogenetic band: Yq11.223

DAZ3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAZ3 gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YM026909:  view genomic region     (about GC identifiers)

Start:
26,909,216 bp from pter      End:
26,959,639 bp from pter
Size:
50,424 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DAZ3_HUMAN, Q9NR90 (See protein sequence)
Recommended Name: Deleted in azoospermia protein 3  
Size: 486 amino acids; 54989 Da
Subunit: Forms a heterodimer with BOLL and DAZL. Interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and DZIP3
Miscellaneous: The DAZ proteins (DAZ, DAZ2, DAZ4 and DAZ4) are all encoded by a strongly repeated region of the Y
chromosome, in two clusters each comprising an inverted pair of DAZ genes. They are very similar, which gives
their indidual characterization difficult. Thus, most experiments do not discriminate between the different
members. One can therefore suppose that reported interactions with a DAZ protein involve all the 4 proteins
Secondary accessions: Q2KHN7
Alternative splicing: 2 isoforms:  Q9NR90-1   Q9NR90-2   

Explore the universe of human proteins at neXtProt for DAZ3: NX_Q9NR90

Explore proteomics data for DAZ3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DAZ3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065097.2  
    ENSEMBL proteins: 
     ENSP00000371802   ENSP00000401049   ENSP00000324965   ENSP00000383073   ENSP00000307537  

    DAZ3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DAZ3
    GenScript Custom Purified and Recombinant Proteins Services for DAZ3
    Novus Biologicals DAZ3 Protein
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DAZ3

     
    Search eBioscience for Proteins for DAZ3 

    DAZ3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DAZ3
    Novus Biologicals DAZ3 Antibodies
    Abcam antibodies for DAZ3
    Cloud-Clone Corp. Antibodies for DAZ3
    ThermoFisher Antibody for DAZ3
    LSBio Antibodies in human, mouse, rat for DAZ3

    DAZ3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DAZ3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DAZ3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DAZ3
    Cloud-Clone Corp. CLIAs for DAZ3
    Search eBioscience for ELISAs for DAZ3 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9NR90

    ProtoNet protein and cluster: Q9NR90

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: DAZ3_HUMAN, Q9NR90
    Domain: The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2
    Similarity: Belongs to the RRM DAZ family
    Similarity: Contains 12 DAZ-like domains
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with DAZ3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAZ3_HUMAN, Q9NR90
    Function: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of
    mRNAs and regulating their translation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
         
    Find genes that share ontologies with DAZ3           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DAZ3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DAZ3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DAZ3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAZ3

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DAZ3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAZ3 (see all 26):
    hsa-miR-4307 hsa-miR-1288 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-500a hsa-miR-548a-3p hsa-miR-144
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DAZ3
    Predesigned siRNA for gene silencing in human, mouse, rat DAZ3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DAZ3

    Clone
    Products:
         
    OriGene clones in human, mouse for DAZ3 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DAZ3 (NM_020364)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAZ3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAZ3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DAZ3
    Browse ESI BIO Cell Lines and PureStem Progenitors for DAZ3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAZ3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DAZ3_HUMAN, Q9NR90: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide
    development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal
    gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DAZ3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DAZ3
    Interactions:

        Search GeneGlobe Interaction Network for DAZ3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for DAZ3 (Q9NR903 ENSP000003718024) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PUM2Q8TB723, ENSP000003381734I2D: score=1 STRING: ENSP00000338173
    DCTN1ENSP000003547914STRING: ENSP00000354791
    DCTN2ENSP000004089104STRING: ENSP00000408910
    DYNC1I1ENSP000003201304STRING: ENSP00000320130
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with DAZ3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAZ3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DAZ3 gene: 
    NM_020364.3  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382365(uc004fwj.4 uc004fwk.3 uc004fwl.3) ENST00000446723
    ENST00000315357 ENST00000400212 ENST00000306737
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DAZ3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAZ3 (see all 26):
    hsa-miR-4307 hsa-miR-1288 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-500a hsa-miR-548a-3p hsa-miR-144
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DAZ3
    Predesigned siRNA for gene silencing in human, mouse, rat DAZ3
    Clone
    Products:
         
    OriGene clones in human, mouse for DAZ3 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DAZ3 (NM_020364)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAZ3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAZ3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DAZ3
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DAZ3
      QuantiTect SYBR Green Assays in human, mouse, rat DAZ3
      QuantiFast Probe-based Assays in human, mouse, rat DAZ3

    16 AceView cDNA sequences:

    AA128463 AA136143 AL705202 BI561663 BG771514 U66077 AF414184 AF248481 
    AA129915 NM_020364 BI562231 AA136029 BC036648 AF248480 NM_020363 BG724038 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DAZ3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DAZ3 Expression
    About this image

    DAZ3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAZ3 Protein Expression

    UniProtKB/Swiss-Prot: DAZ3_HUMAN, Q9NR90
    Tissue specificity: Testis specific

        Custom PCR Arrays for DAZ3
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DAZ3
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DAZ3
    QuantiTect SYBR Green Assays in human, mouse, rat DAZ3
    QuantiFast Probe-based Assays in human, mouse, rat DAZ3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAZ3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DAZ3 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia --
    Uncharacterized protein
    46(a)
    1 → many
    23(26194243-26213200)
    chicken
    (Gallus gallus)
    Aves DAZL6
    Gallus gallus deleted in azoospermia-like (DAZL), ...
    47(a)
    1 → many
    2(34939869-35003900)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    1 → many
    6(34873464-34894381)
    zebrafish
    (Danio rerio)
    Actinopterygii dazl6
    deleted in azoospermia-like
    36(a)
    1 → many
    19(20871401-20886168) ENSDARG00000036214
    fruit fly
    (Drosophila melanogaster)
    Insecta bol6
    boule
    23(a)
    1 → many
    3L(9091208-9123452)
    worm
    (Caenorhabditis elegans)
    Secernentea daz-16
    Protein DAZ-1 (daz-1) mRNA, complete cds
    15(a)
    1 → many
    II(5456305-5458616) WBGene00000935


    ENSEMBL Gene Tree for DAZ3 (if available)
    TreeFam Gene Tree for DAZ3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DAZ3 gene
    DAZ12  DAZL2  DAZ42  DAZ22  BOLL2  
    8 SIMAP similar genes for DAZ3 using alignment to 5 protein entries:     DAZ3_HUMAN (see all proteins):
    DAZ    DAZ1    DAZ4    DAZ2    DAZL    BOLL
    DKFZp666C074    RBMY1A1

    Find genes that share paralogs with DAZ3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    DAZ3_HUMAN, Q9NR90: The number as well as the precise structure of the DAZ proteins probably differs within the
    population


    Selected SNPs for DAZ3 (see all 24)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr Y posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs749977651,2
    C--26908744(+) TGAGGA/GGTTTC 1 -- ds50010--------
    rs560675951,2
    C--26921954(+) TCGGGC/TTAACA 1 -- int10--------
    rs562820771,2
    C--26942316(+) ATAATC/TCTGAA 1 -- int10--------
    rs755414791,2
    C--26951094(+) TCTTTC/TCCTAC 1 -- int10--------
    rs3676267651,2
    ----26922197(+) GTCTAC/TGCTCC 1 -- int10--------
    rs1995374831,2
    ----26935518(+) GTTCTA/CTAGAT 1 -- int10--------
    rs3737880901,2
    ----26928455(+) GGAGAA/CGAGGA 1 -- int10--------
    rs3729667981,2
    ----26942959(+) TCACTA/GTTATT 1 -- int10--------
    rs3708900461,2
    ----26922965(+) CTCAGC/TTAGAA 1 -- int10--------
    rs3717043441,2
    ----26942651(+) ATAGTC/TGACAG 1 -- int10--------

    HapMap Linkage Disequilibrium report for DAZ3 (26909216 - 26959639 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DAZ3 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv10034CNV Loss18304495
    nsv469766CNV Loss16826518
    nsv471613CNV Gain+Loss15918152
    nsv442825CNV CNV18776908
    nsv442826CNV CNV18776908
    essv10843CNV CNV17122850
    dgv2506e1CNV Complex17122850
    dgv2505e1CNV Complex17122850
    nsv515230CNV Complex21397061
    dgv2510e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DAZ3
    DNA2.0 Custom Variant and Variant Library Synthesis for DAZ3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 400027    OMIM disorders: --

    UniProtKB/Swiss-Prot: DAZ3_HUMAN, Q9NR90
  • Spermatogenic failure Y-linked 2 (SPGFY2) [MIM:415000]: A disorder resulting in the absence (azoospermia)
    or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. Note=The disease may be caused
    by mutations affecting the gene represented in this entry. AZFc deletions in the Yq11.23 region including the DAZ
    genes are the most common known genetic cause of human male infertility

  • 4 diseases for DAZ3:    
    About MalaCards
    persistent fetal circulation syndrome    spermatogenic failure, y-linked, 2    azoospermia    y chromosome infertility

    1 disease from the University of Copenhagen DISEASES database for DAZ3:
    Male infertility

    Find genes that share disorders with DAZ3           About GenesLikeMe

    Genetic Association Database (GAD): DAZ3
    Human Genome Epidemiology (HuGE) Navigator: DAZ3 (1 document)

    Export disorders for DAZ3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DAZ3 gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with DAZ3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. (PubMed id 10936047)1, 2, 3 Saxena R.... Page D.C. (Genomics 2000)
    2. [Study on DAZ gene copy deletion in severe oligozoospermia sperm donor for ICSI]. (PubMed id 16963411)1, 4 A Z.C....Lin L. (Yi Chuan 2006)
    3. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (Nature 2003)
    4. Polymorphic DAZ gene family in polymorphic structure of AZFc locus: artwork or functional for human spermatogenesis? (PubMed id 12752250)1, 2 Vogt P.H. and Fernandes S. (APMIS 2003)
    5. Partial DAZ deletions in a family with five infertile brothers. (PubMed id 12801575)1, 2 Gianotten J....van der Veen F. (Fertil. Steril. 2003)
    6. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)1, 2 Moore F.L.... Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    7. A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. (PubMed id 11390979)1, 2 Xu E.Y.... Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2001)
    8. Male infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome. (PubMed id 11095434)1, 2 Moro E.... Foresta C. (J. Clin. Endocrinol. Metab. 2000)
    9. Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PubMed id 10857750)1, 2 Tsui S.... Yen P.H. (Genomics 2000)
    10. In vivo and in vitro analysis of homodimerisation activity of the mouse Dazl1 protein. (PubMed id 10903443)1, 2 Ruggiu M. and Cooke H.J. (Gene 2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 57054 HGNC: 15965 AceView: DAZ Ensembl:ENSG00000187191 euGenes: HUgn57054
    ECgene: DAZ3 H-InvDB: DAZ3

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DAZ3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DAZ3 gene:
    Search GeneIP for patents involving DAZ3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DAZ3  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DAZ3  
     OriGene qSTAR qPCR primer pairs in human, mouse for DAZ3   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DAZ3   OriGene Custom Protein Services for DAZ3  

     
     
     Block miRNA regulation of human, mouse, rat DAZ3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DAZ3
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAZ3 Predesigned siRNA for gene silencing in human, mouse, rat DAZ3
     QuantiFast Probe-based Assays in human, mouse, rat DAZ3 QuantiTect SYBR Green Assays in human, mouse, rat DAZ3
     Custom PCR Arrays for DAZ3 Search Chromatin IP Primers for DAZ3
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat DAZ3 Search GeneGlobe Interaction Network for DAZ3
     Regulatory tfbs in DAZ3 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DAZ3 GenScript cDNA clones with any tag delivered in your preferred vector for DAZ3
     GenScript Custom Assay Services for DAZ3 GenScript Custom overexpressing Cell Line Services for DAZ3
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DAZ3
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DAZ3 antibodies
     DAZ3 proteins
     Antibodies for DAZ3
     See all of Abcam's Antibodies, Kits and Proteins for DAZ3
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DAZ3
     Antibodies for DAZ3
     ELISAs for DAZ3
     CLIAs for DAZ3



     Browse ESI BIO Cell Lines and PureStem Progenitors for DAZ3
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAZ3
     Browse SwitchGear 3'UTR luciferase reporter plasmids for DAZ3
     Browse SwitchGear Promoter luciferase reporter plasmids for DAZ3
     ThermoFisher Antibody for DAZ3
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAZ3
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DAZ3
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DAZ3
     LSBio Antibodies in human, mouse, rat for DAZ3
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DAZ3
      Search eBioscience for proteins for DAZ3
      Search eBioscience for elisas for DAZ3
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DAZ3 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4