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DAZ2 Gene

protein-coding   GIFtS: 48
GCID: GC0YP025365

Deleted In Azoospermia 2

  See DAZ2-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Deleted In Azoospermia 21 2
Deleted In Azoospermia Protein 22
pDP16782

External Ids:    HGNC: 159641   Entrez Gene: 570552   Ensembl: ENSG000002059447   OMIM: 4000265   UniProtKB: Q131173   

Export aliases for DAZ2 gene to outside databases

Previous GC identifers: GC0YP024520 GC0YP024210 GC0YP023703 GC0YP023775


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAZ2 Gene:
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor
(AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an
RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y
within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of
the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number
of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the
gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA
recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results
in multiple transcript variants encoding different isoforms. (provided by RefSeq, Jul 2008)

GeneCards Summary for DAZ2 Gene:
DAZ2 (deleted in azoospermia 2) is a protein-coding gene. Diseases associated with DAZ2 include persistent fetal circulation syndrome, and azoospermia. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is DAZ1.

UniProtKB/Swiss-Prot: DAZ2_HUMAN, Q13117
Function: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of
mRNAs and regulating their translation

Gene Wiki entry for DAZ2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000024.9  NT_011903.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAZ2 gene promoter:
         MEF-2A   SRY   p53   aMEF-2   RSRFC4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAZ2 promoter sequence
   Search Chromatin IP Primers for DAZ2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAZ2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yq11.223   Ensembl cytogenetic band:  Yq11.223   HGNC cytogenetic band: Yq11

DAZ2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAZ2 gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YP025365:  view genomic region     (about GC identifiers)

Start:
25,365,594 bp from pter      End:
25,437,503 bp from pter
Size:
71,910 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DAZ2_HUMAN, Q13117 (See protein sequence)
Recommended Name: Deleted in azoospermia protein 2  
Size: 558 amino acids; 63111 Da
Subunit: Forms a heterodimer with BOLL and DAZL. Interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and DZIP3
Miscellaneous: The DAZ proteins (DAZ, DAZ2, DAZ4 and DAZ4) are all encoded by a strongly repeated region of the Y
chromosome, in two clusters each comprising an inverted pair of DAZ genes. They are very similar, which gives
their indidual characterization difficult. Thus, most experiments do not discriminate between the different
members. One can therefore suppose that reported interactions with a DAZ protein involve all the 4 proteins
Secondary accessions: Q2KHN6 Q96P41 Q9NR91
Alternative splicing: 3 isoforms:  Q13117-1   Q13117-2   Q13117-3   

Explore the universe of human proteins at neXtProt for DAZ2: NX_Q13117

Explore proteomics data for DAZ2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DAZ2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001005785.1  NP_001005786.2  NP_065096.2  

    ENSEMBL proteins: 
     ENSP00000371887   ENSP00000371877   ENSP00000371870   ENSP00000371743   ENSP00000414113  
     ENSP00000371731   ENSP00000371861   ENSP00000383340   ENSP00000371868   ENSP00000371871  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q13117

    ProtoNet protein and cluster: Q13117

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: DAZ2_HUMAN, Q13117
    Domain: The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2
    Similarity: Belongs to the RRM DAZ family
    Similarity: Contains 15 DAZ-like domains
    Similarity: Contains 1 RRM (RNA recognition motif) domain


    Find genes that share domains with DAZ2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAZ2_HUMAN, Q13117
    Function: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of
    mRNAs and regulating their translation

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
         
    Find genes that share ontologies with DAZ2           About GenesLikeMe


    Animal Models:
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    hsa-miR-4307 hsa-miR-1288 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-500a hsa-miR-548a-3p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidDAZ2 3' UTR sequence
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DAZ2_HUMAN, Q13117: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide
    development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal
    gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1
    peroxisome1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DAZ2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DAZ2
    Interactions:

        Search GeneGlobe Interaction Network for DAZ2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for DAZ2 (ENSP000003718704) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DCTN1ENSP000003547914STRING: ENSP00000354791
    DCTN2ENSP000004089104STRING: ENSP00000408910
    DYNC1I1ENSP000003201304STRING: ENSP00000320130
    UBCENSP000003448184STRING: ENSP00000344818
    CRNKL1ENSP000003665574STRING: ENSP00000366557
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0007338single fertilization TAS8896558
    GO:0030154cell differentiation IEA--

    Find genes that share ontologies with DAZ2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAZ2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DAZ2 gene (3 alternative transcripts): 
    NM_001005785.2  NM_001005786.2  NM_020363.3  

    Unigene Cluster for DAZ2:

    Deleted in azoospermia 2
    Hs.592257  [show with all ESTs]
    Unigene Representative Sequence: AK302690
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000382449(uc004fvu.3 uc011nbo.2) ENST00000382440(uc022cok.1 uc022col.1 uc022con.1 uc022coo.1 uc004fvw.3 uc004fvr.3 uc004fvs.3 uc004fvt.3 uc011nbl.2 uc004fvq.3)
    ENST00000382433 ENST00000382306(uc022com.1) ENST00000449947 ENST00000382294
    ENST00000382424(uc010nxl.1) ENST00000400493 ENST00000382431 ENST00000382434

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    Selected qRT-PCR Assays for microRNAs that regulate DAZ2 (see all 26):
    hsa-miR-4307 hsa-miR-1288 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-500a hsa-miR-548a-3p hsa-miR-144
    SwitchGear 3'UTR luciferase reporter plasmidDAZ2 3' UTR sequence
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAZ2
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      QuantiFast Probe-based Assays in human, mouse, rat DAZ2

    Additional mRNA sequence: 

    AF248480.1 AF414184.1 AK302398.1 AK302690.1 BC036648.1 BC113006.1 U21663.1 

    8 DOTS entries:

    DT.100751936  DT.91652055  DT.101980951  DT.120653923  DT.95094558  DT.120651970  DT.120652050  DT.95094557 

    16 AceView cDNA sequences:

    BI561663 AA136143 U66077 BG771514 AF414184 AA128463 AL705202 NM_020364 
    AF248481 AA129915 BI562231 BC036648 AF248480 AA136029 NM_020363 BG724038 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAZ2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DAZ2 Expression
    About this image

    DAZ2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAZ2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.592257

    UniProtKB/Swiss-Prot: DAZ2_HUMAN, Q13117
    Tissue specificity: Testis specific

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DAZ2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dazl1 deleted in azoospermia-like 79.72(n)
    74.76(a)
      13164  NM_010021.5  NP_034151.3 
    chicken
    (Gallus gallus)
    Aves DAZL1 deleted in azoospermia-like 65.79(n)
    60.73(a)
      374054  NM_204218.1  NP_989549.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    45(a)
    1 → many
    6(34873464-34894381)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dazl1 deleted in azoospermia-like 61.59(n)
    59.15(a)
      394676  NM_203748.1  NP_989079.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dazl1 deleted in azoospermia-like 65.93(n)
    65.56(a)
      58039  NM_131524.1  NP_571599.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta bol6
    boule
    23(a)
    1 → many
    3L(9091208-9123452)
    worm
    (Caenorhabditis elegans)
    Secernentea daz-16
    Protein DAZ-1 (daz-1) mRNA, complete cds
    16(a)
    1 → many
    II(5456305-5458616) WBGene00000935


    ENSEMBL Gene Tree for DAZ2 (if available)
    TreeFam Gene Tree for DAZ2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAZ2 gene
    DAZ12  DAZL2  DAZ32  DAZ42  BOLL2  
    8 SIMAP similar genes for DAZ2 using alignment to 6 protein entries:     DAZ2_HUMAN (see all proteins):
    DAZ    DAZ1    DAZ4    DAZ3    DAZL    BOLL
    RBMY1A1    DKFZp666C074

    Find genes that share paralogs with DAZ2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    DAZ2_HUMAN, Q13117: The number as well as the precise structure of the DAZ proteins probably differs within the
    population


    Selected SNPs for DAZ2 (see all 20)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr Y posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs789787981,2
    C--25375741(+) TATTTC/TCAGGC 3 -- int10--------
    rs2004524561,2
    C--25375758(+) TGCTTA/TTCCAC 6 F Y mis10--------
    rs557416311,2
    C--25403039(+) TTTGTC/TGTTGT 3 -- int10--------
    rs790299441,2
    C--25429798(+) CTCTAA/GTACAA 3 -- int10--------
    rs2021883371,2
    ----25402868(+) TTTTTG/TTTTTT 3 -- int10--------
    rs2001859941,2
    ----25402986(+) TTTCCA/GTGTCA 3 -- int10--------
    rs40989411,2
    ----25395867(-) ATATAA/GAGAAT 3 -- int10--------
    rs1444114341,2
    ----25383779(+) TTATTG/TATTGA 3 -- int10--------
    rs3731568331,2
    ----25375759(+) GCTTAA/TCCACA 6 * Y stg10--------
    rs2002078481,2
    ----25379164(+) TTAATG/TTTTTT 3 -- int10--------

    HapMap Linkage Disequilibrium report for DAZ2 (25365594 - 25437503 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DAZ2 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv10034CNV Loss18304495
    nsv469766CNV Loss16826518
    nsv471613CNV Gain+Loss15918152
    nsv442825CNV CNV18776908
    nsv442826CNV CNV18776908
    essv10843CNV CNV17122850
    dgv2506e1CNV Complex17122850
    dgv2505e1CNV Complex17122850
    nsv515230CNV Complex21397061
    dgv2510e1CNV Complex17122850

    Human Gene Mutation Database (HGMD): DAZ2
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing DAZ2
    DNA2.0 Custom Variant and Variant Library Synthesis for DAZ2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 400026    OMIM disorders: --

    UniProtKB/Swiss-Prot: DAZ2_HUMAN, Q13117
  • Spermatogenic failure Y-linked 2 (SPGFY2) [MIM:415000]: A disorder resulting in the absence (azoospermia)
    or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. Note=The disease may be caused
    by mutations affecting the gene represented in this entry. AZFc deletions in the Yq11.23 region including the DAZ
    genes are the most common known genetic cause of human male infertility

  • 6 diseases for DAZ2:    
    About MalaCards
    persistent fetal circulation syndrome    azoospermia    oligospermia    y chromosome infertility
    spermatogenic failure, y-linked, 2    sertoli cell-only syndrome

    4 diseases from the University of Copenhagen DISEASES database for DAZ2:
    Azoospermia     Sertoli cell-only syndrome     Oligospermia     Infertility

    Find genes that share disorders with DAZ2           About GenesLikeMe

    Genetic Association Database (GAD): DAZ2
    Human Genome Epidemiology (HuGE) Navigator: DAZ2 (6 documents)

    Export disorders for DAZ2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAZ2 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with DAZ2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. (PubMed id 10936047)1, 2, 3 Saxena R.... Page D.C. (Genomics 2000)
    2. High frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermia. (PubMed id 11870237)1, 2, 9 Fernandes S.... Vogt P.H. (Mol. Hum. Reprod. 2002)
    3. DAZ1/DAZ2 cluster deletion mediated by gr/gr recombination per se may not be sufficient for spermatogenesis impairment: a study of Chinese normozoospermic men. (PubMed id 16491269)1, 4 Yang Y....Zhang S.X. (Asian J. Androl. 2006)
    4. A frequent partial AZFc deletion does not render an increased risk of spermatogenic impairment in East Asians. (PubMed id 16674553)1, 4 Zhang F....Jin L. (Ann. Hum. Genet. 2006)
    5. [Study on DAZ gene copy deletion in severe oligozoospermia sperm donor for ICSI]. (PubMed id 16963411)1, 4 A Z.C....Lin L. (Yi Chuan 2006)
    6. Preliminary study of the relationship between DAZ gene copy deletions and spermatogenic impairment in Chinese men. (PubMed id 16580401)1, 4 Yang Y....Zhang S. (Fertil. Steril. 2006)
    7. Partial DAZ deletions in a family with five infertile brothers. (PubMed id 12801575)1, 2 Gianotten J....van der Veen F. (Fertil. Steril. 2003)
    8. Human Pumilio-2 is expressed in embryonic stem cells and germ cells and interacts with DAZ (Deleted in AZoospermia) and DAZ-like proteins. (PubMed id 12511597)1, 2 Moore F.L.... Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2003)
    9. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. (PubMed id 12815422)1, 2 Skaletsky H.... Page D.C. (Nature 2003)
    10. Polymorphic DAZ gene family in polymorphic structure of AZFc locus: artwork or functional for human spermatogenesis? (PubMed id 12752250)1, 2 Vogt P.H. and Fernandes S. (APMIS 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57055 HGNC: 15964 AceView: DAZ Ensembl:ENSG00000205944 euGenes: HUgn57055
    ECgene: DAZ2 H-InvDB: DAZ2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DAZ2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DAZ2 gene:
    Search GeneIP for patents involving DAZ2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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