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Aliases for DAZ2 Gene

Aliases for DAZ2 Gene

  • Deleted In Azoospermia 2 2 3 5
  • PDP1678 3

External Ids for DAZ2 Gene

Previous GeneCards Identifiers for DAZ2 Gene

  • GC0YP024520
  • GC0YP024210
  • GC0YP023703
  • GC0YP023775
  • GC0YP025365

Summaries for DAZ2 Gene

Entrez Gene Summary for DAZ2 Gene

  • This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for DAZ2 Gene

DAZ2 (Deleted In Azoospermia 2) is a Protein Coding gene. Diseases associated with DAZ2 include Azoospermia and Male Infertility. GO annotations related to this gene include nucleic acid binding and nucleotide binding. An important paralog of this gene is DAZL.

UniProtKB/Swiss-Prot for DAZ2 Gene

  • RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3-UTR of mRNAs and regulating their translation.

Gene Wiki entry for DAZ2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAZ2 Gene

Genomics for DAZ2 Gene

Regulatory Elements for DAZ2 Gene

Genomic Location for DAZ2 Gene

23,219,434 bp from pter
23,291,356 bp from pter
71,923 bases
Plus strand

Genomic View for DAZ2 Gene

Genes around DAZ2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAZ2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAZ2 Gene

Proteins for DAZ2 Gene

  • Protein details for DAZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Deleted in azoospermia protein 2
    Protein Accession:
    Secondary Accessions:
    • Q2KHN6
    • Q96P41
    • Q9NR91

    Protein attributes for DAZ2 Gene

    558 amino acids
    Molecular mass:
    63111 Da
    Quaternary structure:
    • Forms a heterodimer with BOLL and DAZL. Interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and DZIP3.
    • The DAZ proteins (DAZ, DAZ2, DAZ4 and DAZ4) are all encoded by a strongly repeated region of the Y chromosome, in two clusters each comprising an inverted pair of DAZ genes. They are very similar, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a DAZ protein involve all the 4 proteins.

    Alternative splice isoforms for DAZ2 Gene


neXtProt entry for DAZ2 Gene

Proteomics data for DAZ2 Gene at MOPED

Post-translational modifications for DAZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Abcam antibodies for DAZ2

No data available for DME Specific Peptides for DAZ2 Gene

Domains & Families for DAZ2 Gene

Gene Families for DAZ2 Gene

Protein Domains for DAZ2 Gene

Suggested Antigen Peptide Sequences for DAZ2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2.
  • Belongs to the RRM DAZ family.
  • The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2.
  • Contains 15 DAZ-like domains.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRM DAZ family.
genes like me logo Genes that share domains with DAZ2: view

Function for DAZ2 Gene

Molecular function for DAZ2 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3-UTR of mRNAs and regulating their translation.
genes like me logo Genes that share phenotypes with DAZ2: view

Human Phenotype Ontology for DAZ2 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DAZ2 Gene

MGI Knock Outs for DAZ2:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , miRNA , Transcription Factor Targets and HOMER Transcription for DAZ2 Gene

Localization for DAZ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAZ2 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.

Subcellular locations from

Jensen Localization Image for DAZ2 Gene COMPARTMENTS Subcellular localization image for DAZ2 gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for DAZ2 Gene

Pathways & Interactions for DAZ2 Gene

SuperPathways for DAZ2 Gene

No Data Available

Interacting Proteins for DAZ2 Gene

Gene Ontology (GO) - Biological Process for DAZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007338 single fertilization TAS 8896558
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with DAZ2: view

No data available for Pathways by source and SIGNOR curated interactions for DAZ2 Gene

Drugs & Compounds for DAZ2 Gene

No Compound Related Data Available

Transcripts for DAZ2 Gene

Unigene Clusters for DAZ2 Gene

Deleted in azoospermia 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DAZ2 Gene

No ASD Table

Relevant External Links for DAZ2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DAZ2 Gene

mRNA expression in normal human tissues for DAZ2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAZ2 Gene

This gene is overexpressed in Testis (x26.9), Stomach (x16.7), and Skin - Not Sun Exposed (Suprapubic) (x4.4).

SOURCE GeneReport for Unigene cluster for DAZ2 Gene Hs.592257

mRNA Expression by UniProt/SwissProt for DAZ2 Gene

Tissue specificity: Testis specific.
genes like me logo Genes that share expression patterns with DAZ2: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DAZ2 Gene

Orthologs for DAZ2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DAZ2 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Dazl 35
  • 79.72 (n)
  • 74.76 (a)
Dazl 16
(Pan troglodytes)
Mammalia DAZ2 35
  • 94.88 (n)
  • 89.51 (a)
DAZ 36
  • 86 (a)
DAZ 36
  • 91 (a)
DAZ 36
  • 90 (a)
DAZ 36
  • 48 (a)
(Rattus norvegicus)
Mammalia Dazl 35
  • 80.45 (n)
  • 74.52 (a)
(Bos Taurus)
Mammalia DAZL 36
  • 58 (a)
(Canis familiaris)
Mammalia -- 36
  • 45 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
(Gallus gallus)
Aves DAZL 35
  • 65.79 (n)
  • 60.73 (a)
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dazl 35
  • 61.59 (n)
  • 59.15 (a)
(Danio rerio)
Actinopterygii dazl 35
  • 65.93 (n)
  • 65.56 (a)
dazl 36
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta bol 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea daz-1 36
  • 16 (a)
Species with no ortholog for DAZ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAZ2 Gene

Gene Tree for DAZ2 (if available)
Gene Tree for DAZ2 (if available)

Paralogs for DAZ2 Gene

Paralogs for DAZ2 Gene

(8) SIMAP similar genes for DAZ2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DAZ2: view

Variants for DAZ2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for DAZ2 Gene

The number as well as the precise structure of the DAZ proteins probably differs within the population.

Sequence variations from dbSNP and Humsavar for DAZ2 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type
rs150405 -- 23,283,662(+) CAGAG(C/T)TGCTG intron-variant
rs1273620 -- 23,261,764(+) gaatc(G/T)tggtg intron-variant
rs1273621 -- 23,261,863(+) tcttt(C/T)gatct intron-variant
rs4053670 -- 23,263,022(+) aactt(A/C/G/T)tttgc intron-variant
rs4090454 -- 23,275,379(+) ATTTG(A/C/G/T)ATAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAZ2 Gene

Variant ID Type Subtype PubMed ID
dgv2505e1 CNV Complex 17122850
dgv2506e1 CNV Complex 17122850
nsv10034 CNV Loss 18304495
essv10843 CNV CNV 17122850
dgv2507e1 CNV Complex 17122850
nsv442825 CNV CNV 18776908
dgv2509e1 CNV Complex 17122850
dgv2510e1 CNV Complex 17122850
nsv515230 CNV Complex 21397061
dgv2511e1 CNV Complex 17122850
dgv2512e1 CNV Complex 17122850
nsv469766 CNV Loss 16826518
nsv471613 CNV Gain+Loss 15918152
nsv442826 CNV CNV 18776908

Relevant External Links for DAZ2 Gene

Human Gene Mutation Database (HGMD)

No data available for Variation tolerance for DAZ2 Gene

Disorders for DAZ2 Gene

MalaCards: The human disease database

(7) MalaCards diseases for DAZ2 Gene - From: Orphanet, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
  • spermatogenic failure
male infertility
  • infertility male
spermatogenic failure, y-linked, 2
  • spermatogenic failure y-linked 2
partial deletion of y
  • partial deletion of chromosome y
male reproductive system disease
  • genital diseases, male
- elite association - COSMIC cancer census association via MalaCards
Search DAZ2 in MalaCards View complete list of genes associated with diseases


  • Spermatogenic failure Y-linked 2 (SPGFY2) [MIM:415000]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. {ECO:0000269 PubMed:11095434, ECO:0000269 PubMed:11870237, ECO:0000269 PubMed:12801575}. Note=The disease may be caused by mutations affecting the gene represented in this entry. AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility.

Relevant External Links for DAZ2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DAZ2: view

No data available for Genatlas for DAZ2 Gene

Publications for DAZ2 Gene

  1. Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. (PMID: 10936047) Saxena R. … Page D.C. (Genomics 2000) 2 3 4 67
  2. High frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermia. (PMID: 11870237) Fernandes S. … Vogt P.H. (Mol. Hum. Reprod. 2002) 3 23
  3. Impact of partial DAZ1/2 deletion and partial DAZ3/4 deletion on male infertility. (PMID: 26232607) Zhang Y. … Yang X. (Gene 2015) 3
  4. Combined deletion of DAZ2 and DAZ4 copies of Y chromosome DAZ gene is associated with male infertility in Tunisian men. (PMID: 24878370) Ghorbel M. … Ammar-Keskes L. (Gene 2014) 3
  5. Association of DAZ1/DAZ2 deletion with spermatogenic impairment and male infertility in the South Chinese population. (PMID: 23512232) Li Q. … Yin C.J. (World J Urol 2013) 3

Products for DAZ2 Gene

Sources for DAZ2 Gene