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Aliases for DAZ2 Gene

Aliases for DAZ2 Gene

  • Deleted In Azoospermia 2 2 3
  • Deleted In Azoospermia Protein 2 3
  • PDP1678 3

External Ids for DAZ2 Gene

Previous GeneCards Identifiers for DAZ2 Gene

  • GC0YP024520
  • GC0YP024210
  • GC0YP023703
  • GC0YP023775
  • GC0YP025365

Summaries for DAZ2 Gene

Entrez Gene Summary for DAZ2 Gene

  • This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor (AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA recognition motif (RRM) domain. This gene contains one copy of the 10.8 kb repeat. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]

GeneCards Summary for DAZ2 Gene

DAZ2 (Deleted In Azoospermia 2) is a Protein Coding gene. Diseases associated with DAZ2 include partial deletion of y and oligospermia. GO annotations related to this gene include RNA binding and nucleotide binding. An important paralog of this gene is DAZL.

UniProtKB/Swiss-Prot for DAZ2 Gene

  • RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3-UTR of mRNAs and regulating their translation

Gene Wiki entry for DAZ2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAZ2 Gene

Genomics for DAZ2 Gene

Regulatory Elements for DAZ2 Gene

Genomic Location for DAZ2 Gene

23,219,434 bp from pter
23,291,356 bp from pter
71,923 bases
Plus strand

Genomic View for DAZ2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAZ2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAZ2 Gene

Proteins for DAZ2 Gene

  • Protein details for DAZ2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Deleted in azoospermia protein 2
    Protein Accession:
    Secondary Accessions:
    • Q2KHN6
    • Q96P41
    • Q9NR91

    Protein attributes for DAZ2 Gene

    558 amino acids
    Molecular mass:
    63111 Da
    Quaternary structure:
    • Forms a heterodimer with BOLL and DAZL. Interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and DZIP3.
    • The DAZ proteins (DAZ, DAZ2, DAZ4 and DAZ4) are all encoded by a strongly repeated region of the Y chromosome, in two clusters each comprising an inverted pair of DAZ genes. They are very similar, which gives their indidual characterization difficult. Thus, most experiments do not discriminate between the different members. One can therefore suppose that reported interactions with a DAZ protein involve all the 4 proteins

    Alternative splice isoforms for DAZ2 Gene


neXtProt entry for DAZ2 Gene

Proteomics data for DAZ2 Gene at MOPED

Post-translational modifications for DAZ2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DAZ2 Gene

Domains for DAZ2 Gene

Gene Families for DAZ2 Gene

Protein Domains for DAZ2 Gene

Suggested Antigen Peptide Sequences for DAZ2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2
  • Belongs to the RRM DAZ family.
  • The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2
  • Contains 15 DAZ-like domains.
  • Contains 1 RRM (RNA recognition motif) domain.
  • Belongs to the RRM DAZ family.
genes like me logo Genes that share domains with DAZ2: view

Function for DAZ2 Gene

Molecular function for DAZ2 Gene

UniProtKB/Swiss-Prot Function:
RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3-UTR of mRNAs and regulating their translation

Gene Ontology (GO) - Molecular Function for DAZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding IEA --
GO:0003676 nucleic acid binding --
GO:0003723 RNA binding IEA --
genes like me logo Genes that share ontologies with DAZ2: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAZ2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DAZ2 Gene

Localization for DAZ2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAZ2 Gene

Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis.

Subcellular locations from

Jensen Localization Image for DAZ2 Gene COMPARTMENTS Subcellular localization image for DAZ2 gene
Compartment Confidence
nucleus 5
cytosol 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DAZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DAZ2: view

Pathways for DAZ2 Gene

SuperPathways for DAZ2 Gene

No Data Available

Interacting Proteins for DAZ2 Gene

Gene Ontology (GO) - Biological Process for DAZ2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
GO:0007283 spermatogenesis IEA --
GO:0007338 single fertilization TAS 8896558
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with DAZ2: view

No data available for Pathways by source for DAZ2 Gene

Transcripts for DAZ2 Gene

Unigene Clusters for DAZ2 Gene

Deleted in azoospermia 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAZ2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAZ2 Gene

No ASD Table

Relevant External Links for DAZ2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DAZ2 Gene

mRNA expression in normal human tissues for DAZ2 Gene

mRNA differential expression in normal tissues according to GTEx for DAZ2 Gene

This gene is overexpressed in Testis (26.9), Stomach (16.7), and Skin - Not Sun Exposed (Suprapubic) (4.4).

SOURCE GeneReport for Unigene cluster for DAZ2 Gene Hs.592257

mRNA Expression by UniProt/SwissProt for DAZ2 Gene

Tissue specificity: Testis specific.
genes like me logo Genes that share expressions with DAZ2: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Expression partners for DAZ2 Gene

Orthologs for DAZ2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DAZ2 Gene

Organism Taxonomy Gene Similarity Type Details
(Mus musculus)
Mammalia Dazl 35
  • 79.72 (n)
  • 74.76 (a)
(Pan troglodytes)
Mammalia DAZ2 35
  • 94.88 (n)
  • 89.51 (a)
DAZ 36
  • 86 (a)
DAZ 36
  • 91 (a)
DAZ 36
  • 90 (a)
DAZ 36
  • 48 (a)
(Rattus norvegicus)
Mammalia Dazl 35
  • 80.45 (n)
  • 74.52 (a)
(Bos Taurus)
Mammalia DAZL 36
  • 58 (a)
(Canis familiaris)
Mammalia -- 36
  • 45 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 55 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 43 (a)
(Gallus gallus)
Aves DAZL 35
  • 65.79 (n)
  • 60.73 (a)
  • 46 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dazl 35
  • 61.59 (n)
  • 59.15 (a)
(Danio rerio)
Actinopterygii dazl 35
  • 65.93 (n)
  • 65.56 (a)
dazl 36
  • 36 (a)
fruit fly
(Drosophila melanogaster)
Insecta bol 36
  • 23 (a)
(Caenorhabditis elegans)
Secernentea daz-1 36
  • 16 (a)
Species with no ortholog for DAZ2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAZ2 Gene

Gene Tree for DAZ2 (if available)
Gene Tree for DAZ2 (if available)

Paralogs for DAZ2 Gene

Paralogs for DAZ2 Gene

(8) SIMAP similar genes for DAZ2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DAZ2: view

Variants for DAZ2 Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for DAZ2 Gene

The number as well as the precise structure of the DAZ proteins probably differs within the population

Sequence variations from dbSNP and Humsavar for DAZ2 Gene

SNP ID Clin Chr 0Y pos Sequence Context AA Info Type MAF
rs150405 -- 23,283,662(+) CAGAG(C/T)TGCTG intron-variant
rs1273620 -- 23,261,764(+) gaatc(G/T)tggtg intron-variant
rs1273621 -- 23,261,863(+) tcttt(C/T)gatct intron-variant
rs4090454 -- 23,275,379(+) ATTTG(A/C/T)ATAAA intron-variant
rs4098941 -- 23,249,720(-) ATATA(A/G)AGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAZ2 Gene

Variant ID Type Subtype PubMed ID
dgv2505e1 CNV Complex 17122850
dgv2506e1 CNV Complex 17122850
nsv10034 CNV Loss 18304495
essv10843 CNV CNV 17122850
dgv2507e1 CNV Complex 17122850
nsv442825 CNV CNV 18776908
dgv2509e1 CNV Complex 17122850
dgv2510e1 CNV Complex 17122850
nsv515230 CNV Complex 21397061
dgv2511e1 CNV Complex 17122850
dgv2512e1 CNV Complex 17122850
nsv469766 CNV Loss 16826518
nsv471613 CNV Gain+Loss 15918152
nsv442826 CNV CNV 18776908

Relevant External Links for DAZ2 Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

Disorders for DAZ2 Gene


  • Spermatogenic failure Y-linked 2 (SPGFY2) [MIM:415000]: A disorder resulting in the absence (azoospermia) or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. {ECO:0000269 PubMed:11095434, ECO:0000269 PubMed:11870237, ECO:0000269 PubMed:12801575}. Note=The disease may be caused by mutations affecting the gene represented in this entry. AZFc deletions in the Yq11.23 region including the DAZ genes are the most common known genetic cause of human male infertility.

(4) University of Copenhagen DISEASES for DAZ2 Gene

Relevant External Links for DAZ2

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DAZ2: view

No data available for OMIM , Novoseek inferred disease relationships and Genatlas for DAZ2 Gene

Publications for DAZ2 Gene

  1. High frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermia. (PMID: 11870237) Fernandes S. … Vogt P.H. (Mol. Hum. Reprod. 2002) 3 4 23
  2. Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. (PMID: 10936047) Saxena R. … Page D.C. (Genomics 2000) 2 3 4
  3. DAZ family proteins exist throughout male germ cell development and transit from nucleus to cytoplasm at meiosis in humans and mice. (PMID: 11058556) Reijo R.A. … Page D.C. (Biol. Reprod. 2000) 3 4
  4. Male infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome. (PMID: 11095434) Moro E. … Foresta C. (J. Clin. Endocrinol. Metab. 2000) 3 4
  5. A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. (PMID: 11390979) Xu E.Y. … Reijo Pera R.A. (Proc. Natl. Acad. Sci. U.S.A. 2001) 3 4

Products for DAZ2 Gene

Sources for DAZ2 Gene

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