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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAZ1 Gene

protein-coding   GIFtS: 55
GCID: GC0YM025275

Deleted In Azoospermia 1

(Previous name: deleted in azoospermia)
(Previous symbol: DAZ)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Deleted In Azoospermia 11 2
DAZ1 2 3 5
SPGY2 3
Deleted In Azoospermia1
Deleted In Azoospermia Protein 12

External Ids:    HGNC: 26821   Entrez Gene: 16172   Ensembl: ENSG000001881207   OMIM: 4000035   UniProtKB: Q9NQZ33   

Export aliases for DAZ1 gene to outside databases

Previous GC identifers: GC0YP023708 GC0YP023710 GC0YP023712 GC0YM023684


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DAZ1 Gene:
This gene is a member of the DAZ gene family and is a candidate for the human Y-chromosomal azoospermia factor
(AZF). Its expression is restricted to premeiotic germ cells, particularly in spermatogonia. It encodes an
RNA-binding protein that is important for spermatogenesis. Four copies of this gene are found on chromosome Y
within palindromic duplications; one pair of genes is part of the P2 palindrome and the second pair is part of
the P1 palindrome. Each gene contains a 2.4 kb repeat including a 72-bp exon, called the DAZ repeat; the number
of DAZ repeats is variable and there are several variations in the sequence of the DAZ repeat. Each copy of the
gene also contains a 10.8 kb region that may be amplified; this region includes five exons that encode an RNA
recognition motif (RRM) domain. This gene contains three copies of the 10.8 kb repeat. However, no transcripts
containing three copies of the RRM domain have been described; thus the RefSeq for this gene contains only two
RRM domains. (provided by RefSeq, Jul 2008)

GeneCards Summary for DAZ1 Gene: 
DAZ1 (deleted in azoospermia 1) is a protein-coding gene. Diseases associated with DAZ1 include azoospermia, and y chromosome infertility. GO annotations related to this gene include RNA binding and translation activator activity. An important paralog of this gene is DAZL.

UniProtKB/Swiss-Prot: DAZ1_HUMAN, Q9NQZ3
Function: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of
mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ
cells

Gene Wiki entry for DAZ1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000024.9  NT_011903.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAZ1 gene promoter:
         Max1   p53   MEF-2A   SRY   POU2F1   POU2F1a   FOXO4   aMEF-2   c-Myc   RSRFC4   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for DAZ1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAZ1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Yq11.223   Ensembl cytogenetic band:  Yq11.223   HGNC cytogenetic band: Yq11.223

DAZ1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAZ1 gene location

GeneLoc information about chromosome Y         GeneLoc Exon Structure

GeneLoc location for GC0YM025275:  view genomic region     (about GC identifiers)

Start:
25,275,502 bp from pter      End:
25,345,241 bp from pter
Size:
69,740 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DAZ1_HUMAN, Q9NQZ3 (See protein sequence)
Recommended Name: Deleted in azoospermia protein 1  
Size: 744 amino acids; 82764 Da
Subunit: Forms a heterodimer with BOLL and DAZL. Interacts with PUM2, DAZAP1, DAZAP2, DZIP1 and DZIP3
Subcellular location: Cytoplasm. Nucleus. Note=Predominantly cytoplasmic. Nuclear at some stages of spermatozoide
development. Localizes both to the nuclei and cytoplasm of spermatozoide differentiation. Nuclear in fetal
gonocytes and in spermatogonial nuclei. It then relocates to the cytoplasm during male meiosis
Miscellaneous: DAZ genes are prone to deletions but also to duplications. In a population of infertile men, DAZ
genes deletions are associated with oligozoospermia but an increased number of DAZ genes is not a significant
risk factor for spermatogenic failure
Miscellaneous: The DAZ proteins (DAZ, DAZ2, DAZ4 and DAZ4) are all encoded by a strongly repeated region of the Y
chromosome, in two clusters each comprising an inverted pair of DAZ genes. They are very similar, which gives
their indidual characterization difficult. Thus, most experiments do not discriminate between the different
members. One can therefore suppose that reported interactions with a DAZ protein involve all the 4 proteins
Secondary accessions: Q9NQZ4

Explore the universe of human proteins at neXtProt for DAZ1: NX_Q9NQZ3

Explore proteomics data for DAZ1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NQZ3

  • DAZ1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DAZ1 Protein Expression
    REFSEQ proteins: NP_004072.3  
    ENSEMBL proteins: 
     ENSP00000384573   ENSP00000371950   ENSP00000400716   ENSP00000444407  

    Human Recombinant Protein Products for DAZ1: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DAZ1 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IEA--

    DAZ1 for ontologies           About GeneDecksing



    DAZ1 Antibody Products: 
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    Assay Products for DAZ1: 
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    Cloud-Clone Corp. ELISAs for DAZ1 
    Cloud-Clone Corp. CLIAs for DAZ1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    RBM: RNA binding motif (RRM) containing

    2 InterPro protein domains:
     IPR012677 Nucleotide-bd_a/b_plait
     IPR000504 RRM_dom

    Graphical View of Domain Structure for InterPro Entry Q9NQZ3

    ProtoNet protein and cluster: Q9NQZ3

    1 Blocks protein domain: IPB000504 RNA-binding region RNP-1 (RNA recognition motif)

    UniProtKB/Swiss-Prot: DAZ1_HUMAN, Q9NQZ3
    Domain: The DAZ-like repeats are essential and mediate the interaction with DAZAP1 and DAZAP2
    Similarity: Belongs to the RRM DAZ family
    Similarity: Contains 9 DAZ-like domains
    Similarity: Contains 3 RRM (RNA recognition motif) domains


    DAZ1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAZ1_HUMAN, Q9NQZ3
    Function: RNA-binding protein that plays an essential role in spermatogenesis. May act by binding to the 3'-UTR of
    mRNAs and regulating their translation. Promotes germ-cell progression to meiosis and formation of haploid germ
    cells

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003676nucleic acid binding ----
    GO:0003723RNA binding IEA--
    GO:0005515protein binding IPI12511597
    GO:0008494translation activator activity IDA16001084
         
    DAZ1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DAZ1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DAZ1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DAZ1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAZ1 

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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAZ1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DAZ1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Translational Control
    Translational Control

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for DAZ1
        Translational Control



    DAZ1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAZ1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 11)

    5/14 Interacting proteins for DAZ1 (Q9NQZ31, 2, 3 ENSP000003845734) via UniProtKB, MINT, STRING, and/or I2D (see all 14)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PUM2Q8TB721, 2, 3, ENSP000003381734EBI-997955,EBI-311190 MINT-61576 MINT-45963 MINT-61575 I2D: score=3 STRING: ENSP00000338173
    DAZAP1Q96EP53, ENSP000002330784I2D: score=2 STRING: ENSP00000233078
    DAZLQ929043, ENSP000003823734I2D: score=3 STRING: ENSP00000382373
    BOLLQ8N9W63, ENSP000003147924I2D: score=2 STRING: ENSP00000314792
    DZIP1Q86YF93, ENSP000002573124I2D: score=2 STRING: ENSP00000257312
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0007283spermatogenesis IEA--
    GO:0030154cell differentiation IEA--
    GO:0045948positive regulation of translational initiation IDA16001084

    DAZ1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DAZ1 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DAZ1

    1 Novoseek inferred chemical compound relationship for DAZ1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    testosterone 14 1 11532470 (1)

    Search CenterWatch for drugs/clinical trials and news about DAZ1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DAZ1 gene: 
    NM_004081.5  

    Unigene Clusters for DAZ1:

    Deleted in azoospermia 1
    Hs.70936  [show with all ESTs], Hs.522868  [show with all ESTs]
    Unigene Representative Sequences: NM_001005375, NM_004081
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000405239(uc004fvl.3 uc004fvm.3 uc004fvn.3 uc004fvo.3)
    ENST00000466332(uc004fvk.2) ENST00000382510 ENST00000426000 ENST00000540248

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAZ1
    8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate DAZ1 (see all 26):
    hsa-miR-4307 hsa-miR-1288 hsa-miR-488 hsa-miR-181a-2* hsa-miR-507 hsa-miR-500a hsa-miR-548a-3p hsa-miR-144
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DAZ1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAZ1
    Clone
    Products:
         
    OriGene clones in human, mouse for DAZ1 (see all 7)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DAZ1 (NM_004081)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAZ1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAZ1
    Sirion Biotech Customized lentivirus for stable overexpression of DAZ1 
                         Customized lentivirus expression plasmids for stable overexpression of DAZ1 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAZ1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAZ1

    Additional mRNA sequence: 

    AK310133.1 BC114927.1 U66077.1 

    16 DOTS entries:

    DT.120652058  DT.113441  DT.120653923  DT.95094557  DT.120651970  DT.120653918  DT.100751936  DT.120653754 
    DT.101980951  DT.91652055  DT.100014718  DT.120652060  DT.120652050  DT.120653919  DT.95094558  DT.120651967 

    16 AceView cDNA sequences:

    AA136143 AA128463 BI561663 U66077 AF414184 AL705202 BG771514 AF248481 
    BI562231 AA129915 NM_020364 BC036648 AA136029 AF248480 NM_020363 BG724038 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAZ1 expression in normal human tissues (normalized intensities)      DAZ1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACTTTGTCCA
    DAZ1 Expression
    About this image


    DAZ1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Intestine (Gastrointestinal Tract)    fully expand to see all 2 entries
             small intestine ; glandular cells   
     
     Testis (Reproductive System)
             testis ; cells in seminiferus ducts   
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Kidney (Urinary System)
             kidney ; cells in tubules   
     
     Lower Urinary Tract (Urinary System)
             bladder   

    See DAZ1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAZ1

    SOURCE GeneReport for Unigene clusters: Hs.70936 Hs.522868

    UniProtKB/Swiss-Prot: DAZ1_HUMAN, Q9NQZ3
    Tissue specificity: Testis-specific. Expression restricted to premeiotic germ cells, particularly in spermatogonia
    (at protein level)

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAZ1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DAZ1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves DAZL6
    deleted in azoospermia-like
    44(a)
    1 → many
    2(34939869-35003900)
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    44(a)
    1 → many
    6(34873464-34894381)
    zebrafish
    (Danio rerio)
    Actinopterygii dazl6
    deleted in azoospermia-like
    35(a)
    1 → many
    19(20871401-20886168)
    fruit fly
    (Drosophila melanogaster)
    Insecta bol6
    boule
    19(a)
    1 → many
    3L(9091208-9123452)
    worm
    (Caenorhabditis elegans)
    Secernentea daz-11 Protein DAZ-1 46.59(n)
    34.41(a)
      173931  NM_062635.3  NP_495036.3 
            Species with no ortholog for DAZ1

    ENSEMBL Gene Tree for DAZ1 (if available)
    TreeFam Gene Tree for DAZ1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DAZ1 gene
    DAZ41 2  DAZL2  DAZ32  DAZ22  BOLL2  
    5 SIMAP similar genes for DAZ1 using alignment to 4 protein entries:     DAZ1_HUMAN (see all proteins):
    DAZ    DAZ4    DAZ3    DAZ2    DAZL

    DAZ1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: DAZ1_HUMAN, Q9NQZ3
    Polymorphism: The number as well as the precise structure of the DAZ proteins probably differs within the
    population


    10/12 SNPs in DAZ1 are shown (see all 12)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr Y posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs750323431,2
    C--25312132(+) GAGTAA/GTTAAC 1 -- int10--------
    rs2019448481,2
    C--25334556(+) ATTATC/TGGTCA 1 -- int10--------
    rs3745608231,2
    ----25297209(+) AGTAAC/TGGCTC 1 -- int10--------
    rs3683712331,2
    ----25333988(+) AAAAGC/TTACTG 1 -- int10--------
    rs3710809121,2
    ----25309974(+) ACAACA/GCAAAA 1 -- int10--------
    rs2011691881,2
    ----25301798(+) ATAGTC/TTGACA 1 -- int10--------

    HapMap Linkage Disequilibrium report for DAZ1 (25275502 - 25345241 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DAZ1:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv10034CNV Loss18304495
    essv10843CNV CNV17122850
    dgv2506e1CNV Complex17122850
    dgv2505e1CNV Complex17122850
    dgv2504e1CNV Complex17122850


    Human Gene Mutation Database (HGMD): DAZ1
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 400003    OMIM disorders: --

    UniProtKB/Swiss-Prot: DAZ1_HUMAN, Q9NQZ3
  • Spermatogenic failure Y-linked 2 (SPGFY2) [MIM:415000]: A disorder resulting in the absence (azoospermia)
    or reduction (oligozoospermia) of sperm in the semen, leading to male infertility. Note=The disease may be caused
    by mutations affecting the gene represented in this entry. AZFc deletions in the Yq11.23 region including the DAZ
    genes are the most common known genetic cause of human male infertility

  • 8 diseases for DAZ1:    About MalaCards
    azoospermia    y chromosome infertility    cryptorchidism    oligospermia
    sertoli cell-only syndrome    male infertility    infertility    turner syndrome

    4 diseases from the University of Copenhagen DISEASES database for DAZ1:
    Azoospermia     Sertoli cell-only syndrome     Infertility     Oligospermia

    DAZ1 for disorders           About GeneDecksing

    7 Novoseek inferred disease relationships for DAZ1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    azoospermia 95 84 9695355 (4), 10469697 (3), 9239708 (3), 9557839 (3) (see all 52)
    oligozoospermia 92.7 25 16963411 (3), 9695355 (3), 9091344 (2), 9391878 (1) (see all 16)
    infertility male 89 21 9294855 (2), 9321470 (2), 16078663 (2), 10819768 (1) (see all 16)
    chromosome deletion 76.8 2 9391878 (1), 10402373 (1)
    infertility 69.3 7 16777954 (2), 11390979 (1), 9091344 (1), 16275261 (1) (see all 6)
    chromosomal aberrations 36 5 16078663 (2)
    cryptorchidism 24.3 1 15066457 (1)

    GeneTests: DAZ1
    GeneReviews: DAZ1
    Genetic Association Database (GAD): DAZ1
    Human Genome Epidemiology (HuGE) Navigator: DAZ1 (13 documents)

    Export disorders for DAZ1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAZ1 gene, integrated from 9 sources (see all 139):
    (articles sorted by number of sources associating them with DAZ1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. High frequency of DAZ1/DAZ2 gene deletions in patients with severe oligozoospermia. (PubMed id 11870237)1, 2, 4, 9 Fernandes S.... Vogt P.H. (2002)
    2. Restricted expression of the human DAZ protein in premeiotic germ cells. (PubMed id 18385127)1, 2, 9 Huang W.J....Yen P.H. (2008)
    3. [Study on DAZ gene copy deletion in severe oligozoospermia sperm donor for ICSI] (PubMed id 16963411)1, 4, 9 A Z.C....Lin L. (2006)
    4. Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. (PubMed id 10936047)1, 2, 9 Saxena R.... Page D.C. (2000)
    5. No partial DAZ deletions but frequent gene conversion events on the Y chromosome of fertile men. (PubMed id 16021857)1, 4, 9 Lepretre A.C....Bienvenu T. (2005)
    6. Copy number of DAZ genes in Slovenian and Bosnian general population. (PubMed id 15571102)1, 4, 9 Writzl K....Peterlin B. (2004)
    7. Identification of two novel proteins that interact with germ-cell- specific RNA-binding proteins DAZ and DAZL1. (PubMed id 10857750)1, 2, 9 Tsui S.... Yen P.H. (2000)
    8. [Important genetic etiology of infertile Chinese males: chromosome abnormality and deletion of DAZ gene copy in the AZFc region of Y chromosome] (PubMed id 16078663)1, 4, 9 Yang Y....Lin L. (2005)
    9. A gene family required for human germ cell development evolved from an ancient meiotic gene conserved in metazoans. (PubMed id 11390979)1, 2, 9 Xu E.Y.... Reijo Pera R.A. (2001)
    10. Male infertility caused by a de novo partial deletion of the DAZ cluster on the Y chromosome. (PubMed id 11095434)1, 2, 9 Moro E.... Foresta C. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1617 HGNC: 2682 AceView: DAZ Ensembl:ENSG00000188120 euGenes: HUgn1617
    ECgene: DAZ1 H-InvDB: DAZ1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAZ1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DAZ1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DAZ1 gene:
    Search GeneIP for patents involving DAZ1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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