DAXX Gene
protein-coding GIFtS: 62
GCID: GC06M033286
|
|
death-domain associated protein(Previous name: death-associated protein 6 )
| |
Aliases
for DAXX gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Death-Domain Associated Protein1 2 | | ETS1-Associated Protein 12 3 | | DAP61 2 3 | | CENP-C Binding Protein2 | | Death-Associated Protein 61 2 | | Death Domain-Associated Protein 62 | | Fas Death Domain-Associated Protein2 3 | | Fas-Binding Protein2 | | BING22 3 | | Daxx3 | | EAP12 3 | | HDaxx1 |
Export aliases for DAXX gene to outside databasesPrevious GC identifers: GC06M033298 GC06M033334 GC06M033336 GC06M033394 GC06M033027 |
Summaries
for DAXX gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DAXX:
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the cytoplasm. Itinteracts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and transcriptionfactor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions as a potenttranscription repressor that binds to sumoylated transcription factors. Its repression can be relieved by thesequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associateswith centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis. Thesubcellular localization and function of this protein are modulated by post-translational modifications, includingsumoylation, phosphorylation and polyubiquitination. Alternative splicing results in multiple transcript variants.(provided by RefSeq, Nov 2008)
UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7Function: Transcription corepressor known to repress transcriptional potential of several sumoylated transcriptionfactors. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 isdisrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53stabilization. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signalingfrom TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and blockDAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involveDAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influenceTNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as atranscriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates PAX5activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like thenucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively
Gene Wiki entry for DAXX (Death-associated protein 6)
|
Genomic Views
for DAXX gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NC_018917.1 NT_007592.15 NT_113891.2 NT_167245.1 NT_167247.1 NT_167248.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DAXX gene promoter:
GR p53 AP-1 ATF-2 E2F-2 E2F-1 E2F STAT3 c-Jun GR-alpha
Other transcription factors
Search SABiosciences Chromatin IP Primers for DAXX
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAXX |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6p21.3 Ensembl cytogenetic band: 6p21.32 HGNC cytogenetic band: 6p21.3DAXX Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M033286: view genomic region
(about GC identifiers)
Start:
|
33,286,335 bp from pter |
End:
|
33,297,046 bp from pter |
Size:
|
10,712 bases |
Orientation:
|
minus strand |
4 alternative locations:
| Chr6-,ALT_REF_LOCI_3 33,264,261-33,279,761 | Chr6-,ALT_REF_LOCI_5 33,371,501-33,375,958 | Chr6-,ALT_REF_LOCI_2 33,207,945-33,251,595 | | Chr6-,ALT_REF_LOCI_6 33,215,186-33,255,226 |
|
Proteins
for DAXX gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7 (See
protein sequence)Recommended Name: Death domain-associated protein 6 Size: 740 amino acids; 81373 Da
Subunit: Homomultimer. Binds to the TNFRSF6 death domain via its C-terminus and to PAX5. Binds to SLC2A4/GLUT4, MAP3K5,TGFBR2, phosphorylated dimeric HSPB1/HSP27, CENPC1, ETS1, sumoylated PML, UBE2I and MCRS1. Is part of a complexcontaining PAX5 and CREBBP. Interacts with HIPK2 and HIPK3 via its N-terminus. Interacts with HIPK1, which inducestranslocation from PML/POD/ND10 nuclear bodies to chromatin and enhances association with HDAC1 (By similarity). Thenon-phosphorylated form binds to PAX3, PAX7, DEK, HDAC1, HDAC2, HDAC3, acetylated histone H4 and histones H2A, H2B, H3and H4. Interacts with SPOP. Part of a complex consisting of DAXX, CUL3 and SPOP. Interacts with CBP; the interactionis dependent the sumoylation of CBP and suppresses CBP transcriptional activity via recruitment of HDAC2 directly inthe complex with TP53 and HIPK2. Interacts with AXIN1; the interaction stimulates the interaction of DAXX with TP53,stimulates 'Ser-46' phosphorylation of TP53 on and induces cell death on UV irradiation. Interacts with HCMV tegumentphosphoprotein pp71. Part of a complex with MDM2, DAXX, RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7.Interacts (via N-terminus) with RASSF1 (via C-terminus); the interaction is independent of MDM2 and TP53. Interactswith MDM2; the interaction is direct. Interacts with USP7; the interaction is direct and independent of MDM2 and TP53.Interacts with TP53. Interacts with human cytomegalovirus/HHV-5 protein UL123
Subcellular location: Cytoplasm. Nucleus, nucleoplasm. Nucleus, PML body. Nucleus, nucleolus. Chromosome, centromere.Note=Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli. Colocalizes with a subsetof interphase centromeres, but is absent from mitotic centromeres. Detected in cytoplasmic punctate structures.Translocates from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress. Colocalizes with RASSF1in the nucleus. Colocalizes with USP7 in nucleoplasma with accumulation in speckled structures
6/10 PDB 3D structures from  and Proteopedia  for DAXX (see all 10):2KQS (3D)
2KZS (3D)
2KZU (3D)
4H9N (3D)
4H9O (3D)
4H9P (3D)
Secondary accessions: B4E1I3 F5H082 O14747 O15141 O15208 Q5STK9 Q9BWI3Alternative splicing: 3 isoforms: Q9UER7-1 Q9UER7-2 Q9UER7-3 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for DAXX: NX_Q9UER7
Post-translational modifications:
Sumoylated with SUMO1 on multiple lysine residues1
Phosphorylated by HIPK1 upon glucose deprivation1
Polyubiquitinated; which is promoted by CUL3 and SPOP and results in proteasomal degradation. Ubiquitinated by MDM2;inducing its degradation. Deubiquitinated by USP7; leading to stabilize it1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UER7
DAXX Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001135441.1 NP_001135442.1 NP_001241646.1 NP_001341.1
ENSEMBL proteins: ENSP00000266000 ENSP00000363668 ENSP00000406008 ENSP00000408499 ENSP00000390008 ENSP00000396876
Human Recombinant Protein Products for DAXX:
Gene Ontology (GO): 5/10 cellular component terms (GO ID links to tree view) (see all 10): About this table
DAXX for ontologies About GeneDecksing
DAXX Antibody Products:
Assay Products for DAXX: |
Protein
Domains /
Families
for DAXX gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DAXX for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9UER7ProtoNet protein and cluster: Q9UER7 1 Blocks protein family: IPB005012 Daxx protein
UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7Domain: The Sumo interaction motif mediates Sumo binding, and is required both for sumoylation and binding tosumoylated targetsSimilarity: Belongs to the DAXX family |
Function
for DAXX gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: DAXX_HUMAN, Q9UER7Function: Transcription corepressor known to repress transcriptional potential of several sumoylated transcriptionfactors. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 isdisrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53stabilization. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to signalingfrom TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5 and blockDAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis may not involveDAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influenceTNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as atranscriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates PAX5activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like thenucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectivelyInduction: Upon mitogenic stimulation by concanavalin-A Genatlas biochemistry entry for DAXX:murine Daxx homolog,120kDa,with a dominant transcript ubiquitously expressed,a truncated transcript in placenta andpancreas,and an extended transcript in heart and skeletal muscle,binding to FAS (APT1),enhancing Fas-mediatedapoptosis through the JNK signal transduction pathway,alternatively,potential regulator of FAS-induced apoptosis fromnuclear oncogenic domains PODs in which it colocalizes with PML.
Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10): About this table
DAXX for ontologies About GeneDecksing
Phenotypes:
6 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Daxx):
DAXX for phenotypes About GeneDecksing
Animal Models:
Mouse knock-outs for DAXX: Daxxtm1Led Daxxtm1Maul
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAXX (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DAXX (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): DAXX (NM_001141970) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DAXX | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAXX |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAXX |
|
Pathways & Interactions
for DAXX gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/23 super-pathways (see all 23) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | TWEAK Pathway | | | 2 | Apoptosis and survival_Caspase cascade | | | 3 | Signal transduction_JNK pathway | | | 4 | Proteolysis Putative SUMO-1 pathway | | | 5 | DNA damage Role of SUMO in p53 regulation | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 EMD Millipore Pathways for DAXX
2  R&D Systems Pathways for DAXX
5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DAXX (see all 9)
1 
Cell Signaling Technology (CST) Pathway for DAXX
4  GeneGo (Thomson Reuters) Pathways for DAXX
5/12  BioSystems Pathways for DAXX (see all 12)
2 
Kegg Pathways (Kegg details for DAXX):
DAXX for pathways About GeneDecksing
Interactions:
SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAXX
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
5/132 Interacting proteins for DAXX (Q9UER71, 2, 3 ENSP000003968764) via UniProtKB, MINT, STRING, and/or I2D (see all 132)About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
DAXX for ontologies About GeneDecksing
|
Drugs & Compounds
for DAXX gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DAXX for compounds About GeneDecksing
 Browse Tocris compounds for DAXX
8 Novoseek chemical compound relationships for DAXX gene About this table
Search CenterWatch for drugs/clinical trials and news about DAXX
|
Transcripts
for DAXX gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DAXX gene (4 alternative transcripts): NM_001141969.1 NM_001141970.1 NM_001254717.1 NM_001350.4 Unigene Cluster for DAXX: Death-domain associated protein Hs.336916 [show with all ESTs]Unigene Representative Sequence: AB20949312 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000266000(uc021ywn.1 uc021ywo.1) ENST00000374542(uc003oec.3 uc011dre.2 uc003oed.3 uc011drd.2 uc010juw.2)
ENST00000468536 ENST00000477162 ENST00000490173 ENST00000477370 ENST00000446403
ENST00000453407 ENST00000498030 ENST00000446511 ENST00000494082 ENST00000414083
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAXX (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DAXX (see all 3)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): DAXX (NM_001141970) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DAXX | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAXX |
Additional cDNA sequence: AB209493.1 AF006041.1 AF015956.2 AF039136.1 AF050179.1 AF097742.1 AK223404.1 AK292187.1 AK303767.1 AK303854.1 AK313034.1 BC073776.1 BC109073.1 BC109074.1 CR457085.1 22 DOTS entries: DT.95315871 DT.418007 DT.100825272 DT.95250586 DT.121367046 DT.95340814 DT.100825267 DT.121367044 DT.100825274 DT.91657181 DT.91883192 DT.92449848 DT.100825275 DT.121367021 DT.92449851 DT.95340809 DT.100040497 DT.100042345 DT.100825271 DT.121367065 DT.92449856 DT.100825277 24/396 AceView cDNA sequences (see all 396): BG287523 AI186376 AW574800 AW173049 AU280019 CD369638 AA804768 AA988524 AF050179 AW247173 BM724308 AA807723 CR457085 AL549502 AU141157 AA669990 BM710492 CK725179 AA613090 BU506941 AW248825 CD368592 Z41479 Z45843
GeneLoc Exon Structure
|
Expression
for DAXX gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DAXX expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTGGTGAC
About this image
See DAXX Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DAXX
SOURCE GeneReport for Unigene cluster: Hs.336916
UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7Tissue specificity: Ubiquitous
SABiosciences Expression via Pathway-Focused PCR Arrays including DAXX:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DAXX
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DAXX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAXX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAXX | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAXX |
Orthologs
for DAXX gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DAXX gene from 4/18 species (see all 18) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
mouse
(Mus musculus) |
Mammalia |
Daxx1 , 5 |
Fas death domain-associated protein1, 5 |
78.87(n)1
73.51(a)1 |
|
17 (17.98 cM)5
131631 NM_007829.41 NP_031855.31
339094145 |
African clawed frog
(Xenopus laevis) |
Amphibia |
Xl.247962 |
Xenopus laevis transcribed sequence with weak similarity more |
73.75(n) |
|
BX852563.1 |
zebrafish
(Danio rerio) |
Actinopterygii |
daxx1 |
death-associated protein 6 |
49.8(n)
41.84(a) |
|
561006 NM_001044949.1 NP_001038414.1 |
fruit fly
(Drosophila melanogaster) |
Insecta |
DLP6 |
Daxx-like protein |
7(a) |
1 ↔ 1 |
2L(6480956-6487585) |
ENSEMBL Gene Tree for DAXX (if available)
TreeFam Gene Tree for DAXX (if available) |
Paralogs
for DAXX gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for DAXX gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DAXX (33286335 - 33297046 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DAXX
1 CNV: 69481 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DAXX |
|
Disorders
/ Diseases
for DAXX gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DAXX for disorders About GeneDecksing
OMIM gene information: 603186
OMIM disorders: --
20/27  diseases for DAXX (see all 27): About MalaCardsamyotrophic lateral sclerosis (als) leukemia alpha thalassemia amyotrophic lateral sclerosis
lateral sclerosis herpes simplex systemic lupus erythematosus thalassemia
lupus erythematosus cytomegalovirus infection acute lymphoblastic leukemia lymphoblastic leukemia
fanconi's anemia kaposi's sarcoma neuroendocrine tumor rheumatoid arthritis
acute leukemia anemia sarcoma prostatitis
10/12 Novoseek disease relationships for DAXX gene (see all 12) About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| promyelocytic leukemia |
82 |
21 |
17942542 (2), 12953102 (2), 20097304 (1), 12186918 (1) (see all 13) |
| alpha-thalassemia |
41.1 |
1 |
16406523 (1) |
| herpes simplex |
31.6 |
1 |
16603511 (1) |
| prostatic adenocarcinoma |
22.2 |
1 |
12968034 (1) |
| leukemia |
15 |
7 |
17306074 (2), 11703323 (1), 16331268 (1), 16406523 (1) (see all 5) |
| mental retardation |
10.7 |
3 |
14990586 (1), 16406523 (1) |
| tumors |
8.65 |
7 |
16810318 (1), 19789334 (1), 14761963 (1), 16982744 (1) (see all 5) |
| shock |
1.38 |
2 |
17688194 (1) |
| autoimmune diseases |
0 |
1 |
9407001 (1) |
| necrosis |
0 |
3 |
19789334 (1), 14761963 (1), 19789335 (1) |
Human Genome Epidemiology (HuGE) Navigator: DAXX (4 documents)
Export disorders for DAXX gene to outside databases
|
Publications
for DAXX gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DAXX gene, integrated from 9 sources (see all 241):
(articles sorted by number of sources associating them with DAXX) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Daxx, a novel Fas-binding protein that activates JNK and apoptosis. (PubMed id 9215629)1, 2, 3, 9 Yang X.... Baltimore D. (1997)
- Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region. (PubMed id 9407001)1, 2, 3, 9 Kiriakidou M.... Strauss J.F. III (1997)
- Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. (PubMed id 12140263)1, 2, 9 Hollenbach A.D....Grosveld G. (2002)
- Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization. (PubMed id 12968034)1, 2, 9 Song J.J. and Lee Y.J. (2003)
- Daxx is reciprocally regulated by Mdm2 and Hausp. (PubMed id 20153724)1, 2, 9 Tang J....Yang X. (2010)
- Modification of Daxx by small ubiquitin-related modifier-1. (PubMed id 12150977)1, 2, 9 Jang M.-S.... Kim E. (2002)
- Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm. (PubMed id 11495919)1, 2, 9 Ko Y.-G.... Kim S. (2001)
- BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. (PubMed id 16524876)1, 2, 9 Kwon J.E.... Chung C.H. (2006)
- Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. (PubMed id 17081986)1, 2, 9 Lin D.Y....Shih H.M. (2006)
- HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)- terminal kinase activation and apoptosis in human hepatoma cells. (PubMed id 14678985)1, 2, 9 Hofmann T.G.... Will H. (2003)
|
External Searches for DAXX gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DAXX gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DAXX gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DAXX gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DAXX gene:
Search GeneIP for patents involving DAXX
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DAXX gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for DAXX | | OriGene shRNA RFP for DAXX | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAXX | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DAXX | | | OriGene Protein Over-expression Lysate for DAXX | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DAXX | | OriGene 3'-UTR Clone for DAXX | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DAXX | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAXX | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DAXX | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DAXX | | OriGene Custom Protein Services for DAXX | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DAXX | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DAXX | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAXX | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAXX | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAXX | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAXX |
| |
 |  |  |  | |
| | Antibodies & Assays for DAXX |
| | | | Search Tocris compounds for DAXX |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | DAXX Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAXX |
|  |  |  |  | | | | ThermoFisher Antibody for DAXX |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAXX |
| |  | |
|
|
|
