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DAXX Gene

protein-coding   GIFtS: 61
GCID: GC06M033286

Death-Domain Associated Protein

(Previous name: death-associated protein 6)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Death-Domain Associated Protein1 2     ETS1-Associated Protein 12 3
Death-Associated Protein 61 2     CENP-C Binding Protein2
Fas Death Domain-Associated Protein2 3     Death Domain-Associated Protein 62
BING22 3     Fas-Binding Protein2
DAP62 3     Daxx3
EAP12 3     hDaxx3

External Ids:    HGNC: 26811   Entrez Gene: 16162   Ensembl: ENSG000002042097   OMIM: 6031865   UniProtKB: Q9UER73   
ORGUL members:         

Export aliases for DAXX gene to outside databases

Previous GC identifers: GC06M033298 GC06M033334 GC06M033336 GC06M033394 GC06M033027


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAXX Gene:
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the
cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and
transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions
as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be
relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This
protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to
regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational
modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Nov 2008)

GeneCards Summary for DAXX Gene:
DAXX (death-domain associated protein) is a protein-coding gene. GO annotations related to this gene include enzyme binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7
Function: Transcription corepressor known to repress transcriptional potential of several sumoylated transcription
factors. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2
ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2
self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53
ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is
disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53
stabilization. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to
signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5
and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis
may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may
influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as
a transcriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates
PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like
the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Shows
restriction activity towards human cytomegalovirus (HCMV)

Gene Wiki entry for DAXX (Death-associated protein 6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NT_167247.2  NT_167248.2  NC_018917.2  NT_113891.3  NT_167245.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAXX gene promoter:
         GR   p53   AP-1   ATF-2   E2F-2   E2F-1   E2F   STAT3   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAXX promoter sequence
   Search Chromatin IP Primers for DAXX

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAXX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

DAXX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAXX gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033286:  view genomic region     (about GC identifiers)

Start:
33,286,335 bp from pter      End:
33,297,046 bp from pter
Size:
10,712 bases      Orientation:
minus strand

4 alternative locations:
Chr6-,NT_167247 4,760,078-4,764,535      Chr6-,NT_167248 4,518,583-4,523,042      Chr6-,NT_113891.2 4,730,149-4,734,611     
Chr6-,NT_167245 4,567,658-4,572,120     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7 (See protein sequence)
Recommended Name: Death domain-associated protein 6  
Size: 740 amino acids; 81373 Da
Subunit: Homomultimer. Binds to the TNFRSF6 death domain via its C-terminus and to PAX5. Binds to SLC2A4/GLUT4,
MAP3K5, TGFBR2, phosphorylated dimeric HSPB1/HSP27, CENPC, ETS1, sumoylated PML, UBE2I and MCRS1. Is part of a
complex containing PAX5 and CREBBP. Interacts with HIPK2 and HIPK3 via its N-terminus. Interacts with HIPK1,
which induces translocation from PML/POD/ND10 nuclear bodies to chromatin and enhances association with HDAC1 (By
similarity). The non-phosphorylated form binds to PAX3, PAX7, DEK, HDAC1, HDAC2, HDAC3, acetylated histone H4 and
histones H2A, H2B, H3 and H4. Interacts with SPOP. Part of a complex consisting of DAXX, CUL3 and SPOP. Interacts
with CBP; the interaction is dependent the sumoylation of CBP and suppresses CBP transcriptional activity via
recruitment of HDAC2 directly in the complex with TP53 and HIPK2. Interacts with AXIN1; the interaction
stimulates the interaction of DAXX with TP53, stimulates 'Ser-46' phosphorylation of TP53 on and induces cell
death on UV irradiation. Interacts with HCMV tegument phosphoprotein pp71. Part of a complex with MDM2, DAXX,
RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7. Interacts (via N-terminus) with RASSF1 (via
C-terminus); the interaction is independent of MDM2 and TP53. Interacts with MDM2; the interaction is direct.
Interacts with USP7; the interaction is direct and independent of MDM2 and TP53. Interacts with TP53. Interacts
with human cytomegalovirus/HHV-5 protein UL123
Selected PDB 3D structures from and Proteopedia for DAXX (see all 10):
2KQS (3D)        2KZS (3D)        2KZU (3D)        4H9N (3D)        4H9O (3D)        4H9P (3D)    
Secondary accessions: B4E1I3 F5H082 O14747 O15141 O15208 Q5STK9 Q9BWI3
Alternative splicing: 3 isoforms:  Q9UER7-1   Q9UER7-2   Q9UER7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DAXX: NX_Q9UER7

Explore proteomics data for DAXX at MOPED

Post-translational modifications: 

  • Sumoylated with SUMO1 on multiple lysine residues1
  • Phosphorylated by HIPK1 upon glucose deprivation1
  • Polyubiquitinated; which is promoted by CUL3 and SPOP and results in proteasomal degradation. Ubiquitinated by
    MDM2; inducing its degradation. Deubiquitinated by USP7; leading to stabilize it1
  • Ubiquitination2 at Lys243, Lys277, Lys378, Lys385
  • Modification sites at PhosphoSitePlus

  • See DAXX Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001135441.1  NP_001135442.1  NP_001241646.1  NP_001341.1  

    ENSEMBL proteins: 
     ENSP00000266000   ENSP00000363668   ENSP00000406008   ENSP00000408499   ENSP00000390008  
     ENSP00000396876  

    DAXX Human Recombinant Protein Products:

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    Novus Biologicals DAXX Proteins
    Novus Biologicals DAXX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for DAXX 

     
    antibodies-online proteins for DAXX (7 products) 

     
    antibodies-online peptides for DAXX

    DAXX Antibody Products:

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    Abcam antibodies for DAXX
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    antibodies-online antibodies for DAXX (202 products) 

    DAXX Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for DAXX 
    antibodies-online kits for DAXX (29 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR005012 Daxx

    Graphical View of Domain Structure for InterPro Entry Q9UER7

    ProtoNet protein and cluster: Q9UER7

    1 Blocks protein domain: IPB005012 Daxx protein

    UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7
    Domain: The Sumo interaction motif mediates Sumo binding, and is required both for sumoylation and binding to
    sumoylated targets
    Similarity: Belongs to the DAXX family


    Find genes that share domains with DAXX           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAXX_HUMAN, Q9UER7
    Function: Transcription corepressor known to repress transcriptional potential of several sumoylated transcription
    factors. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2
    ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2
    self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53
    ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is
    disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53
    stabilization. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to
    signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5
    and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis
    may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may
    influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as
    a transcriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates
    PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like
    the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Shows
    restriction activity towards human cytomegalovirus (HCMV)
    Induction: Upon mitogenic stimulation by concanavalin-A

         Genatlas biochemistry entry for DAXX:
    murine Daxx homolog,120kDa,with a dominant transcript ubiquitously expressed,a truncated transcript in placenta
    and pancreas,and an extended transcript in heart and skeletal muscle,binding to FAS (APT1),enhancing Fas-mediated
    apoptosis through the JNK signal transduction pathway,alternatively,potential regulator of FAS-induced apoptosis
    from nuclear oncogenic domains PODs in which it colocalizes with PML.

         Gene Ontology (GO): Selected molecular function terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI16845383
    GO:0005057receptor signaling protein activity TAS9215629
    GO:0005515protein binding IPI10669754
    GO:0008134transcription factor binding IDA10698492
    GO:0019899enzyme binding IPI16845383
         
    Find genes that share ontologies with DAXX           About GenesLikeMe


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Daxx):
     cellular  embryogenesis  growth/size/body  mortality/aging  nervous system 
     normal 

    Find genes that share phenotypes with DAXX           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DAXX: Daxxtm1Led Daxxtm1Maul

       genOway: Develop your customized and physiologically relevant rodent model for DAXX

    miRNA
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    miRTarBase miRNAs that target DAXX:
    hsa-mir-222-3p (MIRT046750), hsa-mir-21-5p (MIRT005327)

    Block miRNA regulation of human, mouse, rat DAXX using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate DAXX:
    hsa-miR-21* hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidDAXX 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DAXX
    Predesigned siRNA for gene silencing in human, mouse, rat DAXX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DAXX

    Clone
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    OriGene ORF clones in mouse, rat for DAXX
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    GenScript: all cDNA clones in your preferred vector (see all 3): DAXX (NM_001141970)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAXX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAXX
    Addgene plasmids for DAXX 

    Cell Line
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAXX


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DAXX_HUMAN, Q9UER7: Cytoplasm. Nucleus, nucleoplasm. Nucleus, PML body. Nucleus, nucleolus. Chromosome,
    centromere. Note=Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli.
    Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres. Detected in
    cytoplasmic punctate structures. Translocates from the nucleus to the cytoplasm upon glucose deprivation or
    oxidative stress. Colocalizes with RASSF1 in the nucleus. Colocalizes with USP7 in nucleoplasma with accumulation
    in speckled structures
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): Selected cellular component terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000792heterochromatin IEA--
    GO:0005634nucleus IMP10698492
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm TAS15572661

    Find genes that share ontologies with DAXX           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAXX About   (see all 23)  
    See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    Apoptosis through Death Receptors0.42
    Apoptotic Pathways Triggered By HIV10.42
    Fas Signaling0.35
    2Amyotrophic lateral sclerosis (ALS)
    Amyotrophic lateral sclerosis (ALS)0.63
    Amyotrophic lateral sclerosis (ALS)0.63
    3MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    4Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    FAS pathway and Stress induction of HSP regulation0.44
    5TGF-Beta Pathway
    MAPK Family Pathway0.60
    JNK Pathway0.51


    Find genes that share SuperPaths with DAXX           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 R&D Systems Pathways for DAXX
        Apoptosis Signaling Pathways
    TGF-beta Signaling Pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DAXX (see all 9)
        Caspase Cascade
    JNK Pathway
    Fas Signaling
    MAPK Family Pathway
    Apoptosis through Death Receptors

    1 Cell Signaling Technology (CST) Pathway for DAXX
        Apoptosis and Autophagy

    4 GeneGo (Thomson Reuters) Pathways for DAXX
        Proteolysis Putative SUMO-1 pathway
    Apoptosis and survival FAS signaling cascades
    Signal transduction JNK pathway
    DNA damage Role of SUMO in p53 regulation

    Selected BioSystems Pathways for DAXX (see all 12)
        MAPK signaling pathway
    Apoptosis Modulation and Signaling
    FAS pathway and Stress induction of HSP regulation
    p38 MAPK Signaling Pathway
    Amyotrophic lateral sclerosis (ALS)


    3 Kegg Pathways  (Kegg details for DAXX):
        MAPK signaling pathway
    Amyotrophic lateral sclerosis (ALS)
    Herpes simplex infection

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DAXX: 
              Prostate Cancer in human mouse rat
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DAXX

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    Selected Interacting proteins for DAXX (Q9UER71, 2, 3 ENSP000003968764) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RASSF1Q9NS231, 2, 3EBI-77321,EBI-367363 MINT-6801600 MINT-6801769 MINT-6801621 MINT-6801754 MINT-6801643 MINT-6801545 MINT-6801679 MINT-6801730 MINT-6801578 I2D: score=3 
    HIST1H4AP628053I2D: score=5 
    HIST1H4BP628053I2D: score=5 
    HIST1H4CP628053I2D: score=5 
    HIST1H4DP628053I2D: score=5 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 13):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis IEA--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IDA15878163
    GO:0006915apoptotic process TAS15572661
    GO:0007257activation of JUN kinase activity TAS9215629

    Find genes that share ontologies with DAXX           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAXX

    8 Novoseek inferred chemical compound relationships for DAXX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 32.6 4 16475184 (1)
    arsenite 31.4 2 10545115 (1), 19690170 (1)
    sb 203580 20.1 1 12968034 (1)
    imatinib 11.1 1 15183120 (1)
    h2o2 3.07 4 16088932 (2), 14505347 (1)
    oligonucleotide 0 1 16088932 (1)
    glucose 0 19 12968034 (7), 15128734 (3), 14505347 (2), 18932217 (1) (see all 6)
    doxorubicin 0 3 15683733 (2)



    Find genes that share compounds with DAXX           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DAXX gene (4 alternative transcripts): 
    NM_001141969.1  NM_001141970.1  NM_001254717.1  NM_001350.4  

    Unigene Cluster for DAXX:

    Death-domain associated protein
    Hs.336916  [show with all ESTs]
    Unigene Representative Sequence: AB209493
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266000(uc021ywn.1 uc021ywo.1) ENST00000374542(uc003oec.3 uc011dre.2 uc003oed.3 uc011drd.2 uc010juw.2)
    ENST00000468536 ENST00000477162 ENST00000490173 ENST00000477370 ENST00000446403
    ENST00000453407 ENST00000498030 ENST00000446511 ENST00000494082 ENST00000414083

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      QuantiFast Probe-based Assays in human, mouse, rat DAXX

    Additional mRNA sequence: 

    AB209493.1 AF006041.1 AF015956.2 AF039136.1 AF050179.1 AF097742.1 AK223404.1 AK292187.1 
    AK303767.1 AK303854.1 AK313034.1 BC073776.1 BC109073.1 BC109074.1 CR457085.1 

    22 DOTS entries:

    DT.95315871  DT.418007  DT.100825272  DT.95250586  DT.121367046  DT.95340814  DT.100825267  DT.121367044 
    DT.100825274  DT.91657181  DT.91883192  DT.92449848  DT.100825275  DT.121367021  DT.92449851  DT.95340809 
    DT.100040497  DT.100042345  DT.100825271  DT.121367065  DT.92449856  DT.100825277 

    Selected AceView cDNA sequences (see all 396):

    BM553283 BM786433 CA308547 BM700093 AW248825 AU280019 AL549502 AA807723 
    AW173049 CB528735 AI078113 BM797072 AW247173 BU164799 CB132242 BG105701 
    AU121667 Z41479 AI433593 AU141157 AI272267 AI239560 CK725179 AA804768 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAXX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGGTGAC
    DAXX Expression
    About this image

    DAXX Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAXX Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.336916

    UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DAXX: 
              Prostate Cancer in human mouse rat
              Apoptosis 384HT in human mouse rat

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAXX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DAXX gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Daxx1 , 5 Fas death domain-associated protein1, 5 78.4(n)1
    72.9(a)1
      17 (17.98 cM)5
    131631  NM_001199733.11  NP_001186662.11 
     339094145 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.247962 Xenopus laevis transcribed sequence with weak similarity more 73.75(n)    BX852563.1 
    zebrafish
    (Danio rerio)
    Actinopterygii daxx6
    death-associated protein 6
    36(a)
    1 ↔ 1
    19(7636988-7656206) ENSDARG00000000729
    fruit fly
    (Drosophila melanogaster)
    Insecta DLP6
    Daxx-like protein
    8(a)
    1 ↔ 1
    2L(6480956-6487585)


    ENSEMBL Gene Tree for DAXX (if available)
    TreeFam Gene Tree for DAXX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAXX (see all 155)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012953121,2
    --33287746(+) CTAACA/GAAACA 4 -- int10--------
    rs2004161621,2
    --33287772(+) GAGAAC/TGTTCC 4 -- int10--------
    rs1463045581,2
    C,F--33287796(+) CTGCTG/CCTTCT 8 /A /G mis11Minor allele frequency- C:0.01NA 4538
    rs749865271,2
    C--33287819(+) TCCTCA/TTCATC 8 E D mis10--------
    rs2005678811,2
    C--33287881(+) CTGTG-/CCTCTCCT 4 A cds10--------
    rs1488607891,2
    C,F--33287936(+) TCATCG/ATCTTC 8 /D syn11Minor allele frequency- A:0.00NA 4552
    rs2016431131,2
    --33287980(+) CCCCTC/GGGATG 8 Q E mis10--------
    rs1397335401,2
    C--33288017(+) AAGAAA/GTTTCT 4 -- int10--------
    rs172216951,2
    C--33288021(+) AGTTTC/TTCTAA 4 -- int11Minor allele frequency- T:0.01MN 96
    rs2007532321,2
    --33288033(+) GAATCC/TCTTGC 4 -- int10--------

    HapMap Linkage Disequilibrium report for DAXX (33286335 - 33297046 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DAXX:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv830634CNV Loss17160897
    esv22635CNV Loss19812545
    nsv830635CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DAXX
    DNA2.0 Custom Variant and Variant Library Synthesis for DAXX

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603186    OMIM disorders: --


    Find genes that share disorders with DAXX           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DAXX gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 82 21 17942542 (2), 12953102 (2), 20097304 (1), 12186918 (1) (see all 13)
    alpha-thalassemia 41.1 1 16406523 (1)
    herpes simplex 31.6 1 16603511 (1)
    prostatic adenocarcinoma 22.2 1 12968034 (1)
    leukemia 15 7 17306074 (2), 11703323 (1), 16331268 (1), 16406523 (1) (see all 5)
    mental retardation 10.7 3 14990586 (1), 16406523 (1)
    tumors 8.65 7 16810318 (1), 19789334 (1), 14761963 (1), 16982744 (1) (see all 5)
    shock 1.38 2 17688194 (1)
    autoimmune diseases 0 1 9407001 (1)
    necrosis 0 3 19789334 (1), 14761963 (1), 19789335 (1)

    Genetic Association Database (GAD): DAXX
    Human Genome Epidemiology (HuGE) Navigator: DAXX (4 documents)

    Export disorders for DAXX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAXX gene, integrated from 10 sources (see all 273):
    (articles sorted by number of sources associating them with DAXX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. (PubMed id 9215629)1, 2, 3, 9 Yang X.... Baltimore D. (Cell 1997)
    2. Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region. (PubMed id 9407001)1, 2, 3, 9 Kiriakidou M.... Strauss J.F. III (DNA Cell Biol. 1997)
    3. Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. (PubMed id 12140263)1, 2, 9 Hollenbach A.D....Grosveld G. (J. Cell Sci. 2002)
    4. Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization. (PubMed id 12968034)1, 2, 9 Song J.J. and Lee Y.J. (J. Biol. Chem. 2003)
    5. Daxx is reciprocally regulated by Mdm2 and Hausp. (PubMed id 20153724)1, 2, 9 Tang J.... Yang X. (Biochem. Biophys. Res. Commun. 2010)
    6. Modification of Daxx by small ubiquitin-related modifier-1. (PubMed id 12150977)1, 2, 9 Jang M.-S.... Kim E. (Biochem. Biophys. Res. Commun. 2002)
    7. Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm. (PubMed id 11495919)1, 2, 9 Ko Y.-G.... Kim S. (J. Biol. Chem. 2001)
    8. BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. (PubMed id 16524876)1, 2, 9 Kwon J.E.... Chung C.H. (J. Biol. Chem. 2006)
    9. Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. (PubMed id 17081986)1, 2, 9 Lin D.Y.... Shih H.M. (Mol. Cell 2006)
    10. HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)- terminal kinase activation and apoptosis in human hepatoma cells. (PubMed id 14678985)1, 2, 9 Hofmann T.G.... Will H. (Cancer Res. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1616 HGNC: 2681 AceView: DAXX Ensembl:ENSG00000204209 euGenes: HUgn1616
    ECgene: DAXX Kegg: 1616 H-InvDB: DAXX

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DAXX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DAXX Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DAXX gene:
    Search GeneIP for patents involving DAXX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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