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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAXX Gene

protein-coding   GIFtS: 61
GCID: GC06M033286

Death-Domain Associated Protein

(Previous name: death-associated protein 6)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Death-Domain Associated Protein1 2     ETS1-Associated Protein 12 3
Death-Associated Protein 61 2     CENP-C Binding Protein2
Fas Death Domain-Associated Protein2 3     Death Domain-Associated Protein 62
BING22 3     Fas-Binding Protein2
DAP62 3     Daxx3
EAP12 3     hDaxx3

External Ids:    HGNC: 26811   Entrez Gene: 16162   Ensembl: ENSG000002042097   OMIM: 6031865   UniProtKB: Q9UER73   
ORGUL members:         
NONCODE14:n407018      

Export aliases for DAXX gene to outside databases

Previous GC identifers: GC06M033298 GC06M033334 GC06M033336 GC06M033394 GC06M033027


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DAXX Gene:
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and in the
cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas, centromere protein C, and
transcription factor erythroblastosis virus E26 oncogene homolog 1. In the nucleus, the encoded protein functions
as a potent transcription repressor that binds to sumoylated transcription factors. Its repression can be
relieved by the sequestration of this protein into promyelocytic leukemia nuclear bodies or nucleoli. This
protein also associates with centromeres in G2 phase. In the cytoplasm, the encoded protein may function to
regulate apoptosis. The subcellular localization and function of this protein are modulated by post-translational
modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing results in
multiple transcript variants. (provided by RefSeq, Nov 2008)

GeneCards Summary for DAXX Gene: 
DAXX (death-domain associated protein) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with DAXX include alpha thalassemia, and cytomegalovirus infection, and among its related super-pathways are HIV-1 Nef- Negative effector of Fas and TNF-alpha and MAPK signaling pathway. GO annotations related to this gene include enzyme binding and protein homodimerization activity.

UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7
Function: Transcription corepressor known to repress transcriptional potential of several sumoylated transcription
factors. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2
ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2
self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53
ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is
disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53
stabilization. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to
signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5
and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis
may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may
influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as
a transcriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates
PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like
the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Shows
restriction activity towards human cytomegalovirus (HCMV)

Gene Wiki entry for DAXX (Death-associated protein 6) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_007592.15  NT_113891.2  NT_167245.1  NT_167247.1  NT_167248.1  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAXX gene promoter:
         GR   p53   AP-1   ATF-2   E2F-2   E2F-1   E2F   STAT3   c-Jun   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAXX promoter sequence
   Search SABiosciences Chromatin IP Primers for DAXX

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAXX


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

DAXX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAXX gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033286:  view genomic region     (about GC identifiers)

Start:
33,286,335 bp from pter      End:
33,297,046 bp from pter
Size:
10,712 bases      Orientation:
minus strand

4 alternative locations:
Chr6-,NT_113891.2 4,730,149-4,734,611      Chr6-,NT_167247 4,760,078-4,764,535      Chr6-,NT_167245 4,567,658-4,572,120     
Chr6-,NT_167248 4,518,583-4,523,042     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7 (See protein sequence)
Recommended Name: Death domain-associated protein 6  
Size: 740 amino acids; 81373 Da
Subunit: Homomultimer. Binds to the TNFRSF6 death domain via its C-terminus and to PAX5. Binds to SLC2A4/GLUT4,
MAP3K5, TGFBR2, phosphorylated dimeric HSPB1/HSP27, CENPC1, ETS1, sumoylated PML, UBE2I and MCRS1. Is part of a
complex containing PAX5 and CREBBP. Interacts with HIPK2 and HIPK3 via its N-terminus. Interacts with HIPK1,
which induces translocation from PML/POD/ND10 nuclear bodies to chromatin and enhances association with HDAC1 (By
similarity). The non-phosphorylated form binds to PAX3, PAX7, DEK, HDAC1, HDAC2, HDAC3, acetylated histone H4 and
histones H2A, H2B, H3 and H4. Interacts with SPOP. Part of a complex consisting of DAXX, CUL3 and SPOP. Interacts
with CBP; the interaction is dependent the sumoylation of CBP and suppresses CBP transcriptional activity via
recruitment of HDAC2 directly in the complex with TP53 and HIPK2. Interacts with AXIN1; the interaction
stimulates the interaction of DAXX with TP53, stimulates 'Ser-46' phosphorylation of TP53 on and induces cell
death on UV irradiation. Interacts with HCMV tegument phosphoprotein pp71. Part of a complex with MDM2, DAXX,
RASSF1 and USP7. Part of a complex with DAXX, MDM2 and USP7. Interacts (via N-terminus) with RASSF1 (via
C-terminus); the interaction is independent of MDM2 and TP53. Interacts with MDM2; the interaction is direct.
Interacts with USP7; the interaction is direct and independent of MDM2 and TP53. Interacts with TP53. Interacts
with human cytomegalovirus/HHV-5 protein UL123
Subcellular location: Cytoplasm. Nucleus, nucleoplasm. Nucleus, PML body. Nucleus, nucleolus. Chromosome,
centromere. Note=Dispersed throughout the nucleoplasm, in PML/POD/ND10 nuclear bodies, and in nucleoli.
Colocalizes with a subset of interphase centromeres, but is absent from mitotic centromeres. Detected in
cytoplasmic punctate structures. Translocates from the nucleus to the cytoplasm upon glucose deprivation or
oxidative stress. Colocalizes with RASSF1 in the nucleus. Colocalizes with USP7 in nucleoplasma with accumulation
in speckled structures
6/10 PDB 3D structures from and Proteopedia for DAXX (see all 10):
2KQS (3D)        2KZS (3D)        2KZU (3D)        4H9N (3D)        4H9O (3D)        4H9P (3D)    
Secondary accessions: B4E1I3 F5H082 O14747 O15141 O15208 Q5STK9 Q9BWI3
Alternative splicing: 3 isoforms:  Q9UER7-1   Q9UER7-2   Q9UER7-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DAXX: NX_Q9UER7

Explore proteomics data for DAXX at MOPED 

Post-translational modifications:

  • UniProtKB: Sumoylated with SUMO1 on multiple lysine residues
  • UniProtKB: Phosphorylated by HIPK1 upon glucose deprivation
  • UniProtKB: Polyubiquitinated; which is promoted by CUL3 and SPOP and results in proteasomal degradation. Ubiquitinated by
    MDM2; inducing its degradation. Deubiquitinated by USP7; leading to stabilize it
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UER7

  • DAXX Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DAXX Protein Expression
    REFSEQ proteins (4 alternative transcripts): 
    NP_001135441.1  NP_001135442.1  NP_001241646.1  NP_001341.1  

    ENSEMBL proteins: 
     ENSP00000266000   ENSP00000363668   ENSP00000406008   ENSP00000408499   ENSP00000390008  
     ENSP00000396876  

    Human Recombinant Protein Products for DAXX: 
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    OriGene Purified Proteins for DAXX
    OriGene Protein Over-expression Lysate for DAXX
    OriGene MassSpec for DAXX 
    OriGene Custom Protein Services for DAXX
    GenScript Custom Purified and Recombinant Proteins Services for DAXX
    Novus Biologicals DAXX Proteins
    Novus Biologicals DAXX Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0000792heterochromatin IEA--
    GO:0005634nucleus IMP10698492
    GO:0005730nucleolus IEA--
    GO:0005737cytoplasm TAS15572661

    DAXX for ontologies           About GeneDecksing



    DAXX Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of DAXX
    R&D Systems Antibodies for DAXX
    Cell Signaling Technology (CST) Antibodies for DAXX 
    OriGene Antibodies for DAXX
    OriGene Custom Antibody Services for DAXX
    GenScript Superior Antibodies for DAXX
    Novus Biologicals DAXX Antibodies
    Abcam antibodies for DAXX
    Browse Antibodies at Cloud-Clone Corp. 
    ThermoFisher Antibody for DAXX
    LSBio Antibodies in human, mouse, rat for DAXX 

    Assay Products for DAXX: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DAXX
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DAXX
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR005012 Daxx

    Graphical View of Domain Structure for InterPro Entry Q9UER7

    ProtoNet protein and cluster: Q9UER7

    1 Blocks protein domain: IPB005012 Daxx protein

    UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7
    Domain: The Sumo interaction motif mediates Sumo binding, and is required both for sumoylation and binding to
    sumoylated targets
    Similarity: Belongs to the DAXX family


    DAXX for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAXX_HUMAN, Q9UER7
    Function: Transcription corepressor known to repress transcriptional potential of several sumoylated transcription
    factors. Acts as an adapter protein in a MDM2-DAXX-USP7 complex by regulating the RING-finger E3 ligase MDM2
    ubiquitination activity. Under non-stress condition, in association with the deubiquitinating USP7, prevents MDM2
    self-ubiquitination and enhances the intrinsic E3 ligase activity of MDM2 towards TP53, thereby promoting TP53
    ubiquitination and subsequent proteasomal degradation. Upon DNA damage, its association with MDM2 and USP7 is
    disrupted, resulting in increased MDM2 autoubiquitination and consequently, MDM2 degradation, which leads to TP53
    stabilization. Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to
    signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with TNFRSF6 and MAP3K5
    and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC activation and TNFRSF6-mediated apoptosis
    may not involve DAXX. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may
    influence TNFRSF6-dependent apoptosis thereby. Down-regulates basal and activated transcription. Seems to act as
    a transcriptional corepressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates
    PAX5 activity. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like
    the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Shows
    restriction activity towards human cytomegalovirus (HCMV)
    Induction: Upon mitogenic stimulation by concanavalin-A

         Genatlas biochemistry entry for DAXX:
    murine Daxx homolog,120kDa,with a dominant transcript ubiquitously expressed,a truncated transcript in placenta
    and pancreas,and an extended transcript in heart and skeletal muscle,binding to FAS (APT1),enhancing Fas-mediated
    apoptosis through the JNK signal transduction pathway,alternatively,potential regulator of FAS-induced apoptosis
    from nuclear oncogenic domains PODs in which it colocalizes with PML.

         Gene Ontology (GO): 5/10 molecular function terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002039p53 binding IPI16845383
    GO:0005057receptor signaling protein activity TAS9215629
    GO:0005515protein binding IPI10669754
    GO:0008134transcription factor binding IDA10698492
    GO:0019899enzyme binding IPI16845383
         
    DAXX for ontologies           About GeneDecksing


    Phenotypes:
         6 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Daxx):
     cellular  embryogenesis  growth/size  mortality/aging  nervous system 
     normal 

    DAXX for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DAXX: Daxxtm1Led Daxxtm1Maul

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DAXX 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DAXX

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DAXX 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAXX 

    miRNA
    Products:
        
    miRTarBase miRNAs that target DAXX:
    hsa-mir-21 (MIRT005327)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAXX
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DAXX:
    hsa-miR-21* hsa-miR-3133
    SwitchGear 3'UTR luciferase reporter plasmidDAXX 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DAXX
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAXX

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DAXX
    Sirion Biotech Customized adenovirus for overexpression of DAXX

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DAXX (see all 19)
    OriGene ORF clones in mouse, rat for DAXX
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DAXX (NM_001141970)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAXX
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAXX
    Sirion Biotech Customized lentivirus for stable overexpression of DAXX 
                         Customized lentivirus expression plasmids for stable overexpression of DAXX 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DAXX
    Search LifeMap BioReagents cell lines for DAXX
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAXX


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DAXX About   (see all 23)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    Apoptosis through Death Receptors0.42
    Apoptotic Pathways Triggered By HIV10.42
    Fas Signaling0.35
    2MAPK signaling pathway
    MAPK signaling pathway0.50
    MAPK signaling pathway0.50
    3Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    FAS pathway and Stress induction of HSP regulation0.44
    4TGF-Beta Pathway
    MAPK Family Pathway0.60
    JNK Pathway0.51
    5DNA damage Role of SUMO in p53 regulation
    Proteolysis Putative SUMO-1 pathway0.33
    DNA damage Role of SUMO in p53 regulation0.33

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    4 EMD Millipore Pathways for DAXX
        Proteolysis Putative SUMO-1 pathway
    Apoptosis and survival FAS signaling cascades
    Signal transduction JNK pathway
    DNA damage Role of SUMO in p53 regulation

    2 R&D Systems Pathways for DAXX
        Apoptosis Signaling Pathways
    TGF-beta Signaling Pathways

    5/9 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DAXX (see all 9)
        Caspase Cascade
    JNK Pathway
    Fas Signaling
    MAPK Family Pathway
    Apoptosis through Death Receptors

    1 Cell Signaling Technology (CST) Pathway for DAXX
        Apoptosis and Autophagy

    4 GeneGo (Thomson Reuters) Pathways for DAXX
        Proteolysis Putative SUMO-1 pathway
    Apoptosis and survival FAS signaling cascades
    Signal transduction JNK pathway
    DNA damage Role of SUMO in p53 regulation

    5/11 BioSystems Pathways for DAXX (see all 11)
        MAPK signaling pathway
    Apoptosis Modulation and Signaling
    p38 MAPK Signaling Pathway
    FAS pathway and Stress induction of HSP regulation
    TGF-beta Receptor Signaling Pathway


    3         Kegg Pathways  (Kegg details for DAXX):
        MAPK signaling pathway
    Amyotrophic lateral sclerosis (ALS)
    Herpes simplex infection


    DAXX for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAXX

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5/132 Interacting proteins for DAXX (Q9UER71, 2, 3 ENSP000003968764) via UniProtKB, MINT, STRING, and/or I2D (see all 132)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RASSF1Q9NS232, 3MINT-6801600 MINT-6801769 MINT-6801621 MINT-6801754 MINT-6801643 MINT-6801545 MINT-6801679 MINT-6801730 MINT-6801578 I2D: score=3 
    HIST1H4AP628053I2D: score=5 
    HIST1H4BP628053I2D: score=5 
    HIST1H4CP628053I2D: score=5 
    HIST1H4DP628053I2D: score=5 
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281mitotic cytokinesis IEA--
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IDA15878163
    GO:0006915apoptotic process TAS15572661
    GO:0007257activation of JUN kinase activity TAS9215629

    DAXX for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DAXX for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DAXX

    8 Novoseek inferred chemical compound relationships for DAXX gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 32.6 4 16475184 (1)
    arsenite 31.4 2 10545115 (1), 19690170 (1)
    sb 203580 20.1 1 12968034 (1)
    imatinib 11.1 1 15183120 (1)
    h2o2 3.07 4 16088932 (2), 14505347 (1)
    oligonucleotide 0 1 16088932 (1)
    glucose 0 19 12968034 (7), 15128734 (3), 14505347 (2), 18932217 (1) (see all 6)
    doxorubicin 0 3 15683733 (2)

    Search CenterWatch for drugs/clinical trials and news about DAXX

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DAXX gene (4 alternative transcripts): 
    NM_001141969.1  NM_001141970.1  NM_001254717.1  NM_001350.4  

    Unigene Cluster for DAXX:

    Death-domain associated protein
    Hs.336916  [show with all ESTs]
    Unigene Representative Sequence: AB209493
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000266000(uc021ywn.1 uc021ywo.1) ENST00000374542(uc003oec.3 uc011dre.2 uc003oed.3 uc011drd.2 uc010juw.2)
    ENST00000468536 ENST00000477162 ENST00000490173 ENST00000477370 ENST00000446403
    ENST00000453407 ENST00000498030 ENST00000446511 ENST00000494082 ENST00000414083

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DAXX:
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    SwitchGear 3'UTR luciferase reporter plasmidDAXX 3' UTR sequence
    Inhib. RNA
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    Additional mRNA sequence: 

    AB209493.1 AF006041.1 AF015956.2 AF039136.1 AF050179.1 AF097742.1 AK223404.1 AK292187.1 
    AK303767.1 AK303854.1 AK313034.1 BC073776.1 BC109073.1 BC109074.1 CR457085.1 

    22 DOTS entries:

    DT.95315871  DT.418007  DT.100825272  DT.95250586  DT.121367046  DT.95340814  DT.100825267  DT.121367044 
    DT.100825274  DT.91657181  DT.91883192  DT.92449848  DT.100825275  DT.121367021  DT.92449851  DT.95340809 
    DT.100040497  DT.100042345  DT.100825271  DT.121367065  DT.92449856  DT.100825277 

    24/396 AceView cDNA sequences (see all 396):

    BM743789 AW247173 AI744369 AI277657 BU180713 BU506941 BQ639481 BM700093 
    BM705276 CK725179 AW513420 BM742836 CB156098 BQ064324 AI186376 BM787247 
    BG287523 BM786433 BM710492 AI753509 AW151830 CB132242 BM700146 BG105701 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAXX expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCCTGGTGAC
    DAXX Expression
    About this image


    See DAXX Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAXX

    SOURCE GeneReport for Unigene cluster: Hs.336916

    UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Arrays including DAXX: 
              Prostate Cancer in human mouse rat
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DAXX gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Daxx1 , 5 Fas death domain-associated protein1, 5 78.87(n)1
    73.51(a)1
      17 (17.98 cM)5
    131631  NM_007829.41  NP_031855.31 
     339094145 
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.247962 Xenopus laevis transcribed sequence with weak similarity more 73.75(n)    BX852563.1 
    zebrafish
    (Danio rerio)
    Actinopterygii daxx1 death-associated protein 6 49.8(n)
    41.84(a)
      561006  NM_001044949.1  NP_001038414.1 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0094321 AGAP009432-PA 42.69(n)
    28.89(a)
      5668164  XM_001687769.1  XP_001687821.1 


    ENSEMBL Gene Tree for DAXX (if available)
    TreeFam Gene Tree for DAXX (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/155 SNPs in DAXX are shown (see all 155)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2012953121,2
    --33287746(+) CTAACA/GAAACA 4 -- int10--------
    rs2004161621,2
    --33287772(+) GAGAAC/TGTTCC 4 -- int10--------
    rs1463045581,2
    C,F--33287796(+) CTGCTG/CCTTCT 8 /A /G mis11Minor allele frequency- C:0.01NA 4538
    rs749865271,2
    C--33287819(+) TCCTCA/TTCATC 8 E D mis10--------
    rs2005678811,2
    C--33287881(+) CTGTG-/CCTCTCCT 4 A cds10--------
    rs1488607891,2
    C,F--33287936(+) TCATCG/ATCTTC 8 /D syn11Minor allele frequency- A:0.00NA 4552
    rs2016431131,2
    --33287980(+) CCCCTC/GGGATG 8 Q E mis10--------
    rs1397335401,2
    C--33288017(+) AAGAAA/GTTTCT 4 -- int10--------
    rs172216951,2
    C--33288021(+) AGTTTC/TTCTAA 4 -- int11Minor allele frequency- T:0.01MN 96
    rs2007532321,2
    --33288033(+) GAATCC/TCTTGC 4 -- int10--------

    HapMap Linkage Disequilibrium report for DAXX (33286335 - 33297046 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DAXX:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv830634CNV Loss17160897
    esv22635CNV Loss19812545
    nsv830635CNV Loss17160897

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603186    OMIM disorders: --

    20/31 diseases for DAXX (see all 31):    About MalaCards
    alpha thalassemia    cytomegalovirus infection    thalassemia    herpes simplex
    neuroendocrine tumor    lateral sclerosis    amyotrophic lateral sclerosis    leukemia
    kaposi's sarcoma    prostate adenocarcinoma    fanconi's anemia    acute leukemia
    acute lymphoblastic leukemia    mental retardation    lymphoblastic leukemia    anemia
    sarcoma    type 1 diabetes    systemic lupus erythematosus    lupus erythematosus


    DAXX for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    10/12 Novoseek inferred disease relationships for DAXX gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 82 21 17942542 (2), 12953102 (2), 20097304 (1), 12186918 (1) (see all 13)
    alpha-thalassemia 41.1 1 16406523 (1)
    herpes simplex 31.6 1 16603511 (1)
    prostatic adenocarcinoma 22.2 1 12968034 (1)
    leukemia 15 7 17306074 (2), 11703323 (1), 16331268 (1), 16406523 (1) (see all 5)
    mental retardation 10.7 3 14990586 (1), 16406523 (1)
    tumors 8.65 7 16810318 (1), 19789334 (1), 14761963 (1), 16982744 (1) (see all 5)
    shock 1.38 2 17688194 (1)
    autoimmune diseases 0 1 9407001 (1)
    necrosis 0 3 19789334 (1), 14761963 (1), 19789335 (1)

    Genetic Association Database (GAD): DAXX
    Human Genome Epidemiology (HuGE) Navigator: DAXX (4 documents)

    Export disorders for DAXX gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAXX gene, integrated from 9 sources (see all 267):
    (articles sorted by number of sources associating them with DAXX)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Daxx, a novel Fas-binding protein that activates JNK and apoptosis. (PubMed id 9215629)1, 2, 3, 9 Yang X.... Baltimore D. (1997)
    2. Cloning and expression of primate Daxx cDNAs and mapping of the human gene to chromosome 6p21.3 in the MHC region. (PubMed id 9407001)1, 2, 3, 9 Kiriakidou M.... Strauss J.F. III (1997)
    3. Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek. (PubMed id 12140263)1, 2, 9 Hollenbach A.D....Grosveld G. (2002)
    4. Role of the ASK1-SEK1-JNK1-HIPK1 signal in Daxx trafficking and ASK1 oligomerization. (PubMed id 12968034)1, 2, 9 Song J.J. and Lee Y.J. (2003)
    5. Daxx is reciprocally regulated by Mdm2 and Hausp. (PubMed id 20153724)1, 2, 9 Tang J....Yang X. (2010)
    6. Modification of Daxx by small ubiquitin-related modifier-1. (PubMed id 12150977)1, 2, 9 Jang M.-S.... Kim E. (2002)
    7. Apoptosis signal-regulating kinase 1 controls the proapoptotic function of death-associated protein (Daxx) in the cytoplasm. (PubMed id 11495919)1, 2, 9 Ko Y.-G.... Kim S. (2001)
    8. BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase. (PubMed id 16524876)1, 2, 9 Kwon J.E.... Chung C.H. (2006)
    9. Role of SUMO-interacting motif in Daxx SUMO modification, subnuclear localization, and repression of sumoylated transcription factors. (PubMed id 17081986)1, 2, 9 Lin D.Y....Shih H.M. (2006)
    10. HIPK2 regulates transforming growth factor-beta-induced c-Jun NH(2)- terminal kinase activation and apoptosis in human hepatoma cells. (PubMed id 14678985)1, 2, 9 Hofmann T.G.... Will H. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1616 HGNC: 2681 AceView: DAXX Ensembl:ENSG00000204209 euGenes: HUgn1616
    ECgene: DAXX Kegg: 1616 H-InvDB: DAXX

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAXX Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DAXX Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DAXX gene:
    Search GeneIP for patents involving DAXX

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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