V3 here soon-try beta now
Gene Search (GeneCards Home) | GeneCards Guide | User Feedback | Terms of Use | Notice about third-party sites
 

DAXX Gene

protein-coding   GIFtS: 66

GC06M033394
death-domain associated protein
(Previous name: death-associated protein 6 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    

Aliases &
Descriptions
for DAXX

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
BING2 2, 3
DAP6 1, 2, 3
Daxx 3
EAP1 2, 3
MGC126245 2
MGC126246 2
OTTHUMP00000029289 2
OTTHUMP00000029290 2
hDaxx 3
Descriptions
CENP-C binding protein 2
ETS1-associated protein 1 2, 3
Fas death domain-associated protein 3
Fas-binding protein 2
death-associated protein 6 1, 2
death-domain associated protein 2
External Ids
HGNC: 26811
Entrez Gene: 16162
UniProtKB: Q9UER73
Ensembl: ENSG000002042097
Search outside databases for aliases for DAXX gene

Previous GC identifers: GC06M033298 GC06M033334 GC06M033336

Summaries
for DAXX

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

 EntrezGene summary for DAXX:
This gene encodes a multifunctional protein that resides in multiple locations in the nucleus and
in the cytoplasm. It interacts with a wide variety of proteins, such as apoptosis antigen Fas,
centromere protein C, and transcription factor erythroblastosis virus E26 oncogene homolog 1. In
the nucleus, the encoded protein functions as a potent transcription repressor that binds to
sumoylated transcription factors. Its repression can be relieved by the sequestration of this
protein into promyelocytic leukemia nuclear bodies or nucleoli. This protein also associates with
centromeres in G2 phase. In the cytoplasm, the encoded protein may function to regulate apoptosis.
The subcellular localization and function of this protein are modulated by post-translational
modifications, including sumoylation, phosphorylation and polyubiquitination. Alternative splicing
results in multiple transcript variants. [provided by RefSeq]

UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7
Function: Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to
signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with
TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC
activation and TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in
PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis
thereby. Down-regulates basal and activated transcription. Seems to act as a transcriptional
co-repressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates PAX5
activity. Its transcription repressor activity is modulated by recruiting it to subnuclear
compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and
PML, respectively

Gene Wiki entry for DAXX (Death_associated_protein_6)

Genomic Location
for DAXX

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the DAXX gene  

Entrez Gene cytogenetic band: 6p21.3   Ensembl cytogenetic band:  6p21.32   HGNC cytogenetic band: 6p21.3

DAXX Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M033394:     (about GC identifiers)

Start:
 33,394,313 bp from pter
End:
 33,398,765 bp from pter
Size:
 4,453 bases
Orientation:
 minus strand

2 alternative locations:
Chr6-,c6_COX 33,355,073-33,359,392      Chr6-,c6_QBL 33,358,093-33,362,409     
RefSeq DNA sequence:
NC_000006.10  NT_007592.14  NT_113891.1  NT_113897.1  

Proteins
for DAXX

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

 UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7 (See protein sequence)
Recommended Name: Death domain-associated protein 6  
Size: 740 amino acids; 81373 Da
Subunit: Homomultimer. Binds to the TNFRSF6 death domain via its C-terminus and to PAX5. Binds to
SLC2A4/GLUT4, MAP3K5, TGFBR2, phosphorylated dimeric HSPB1/HSP27, CENPC1, ETS1, sumoylated PML,
UBE2I and MCRS1. Is part of a complex containing PAX5 and CREBBP. Interacts with HIPK2 and HIPK3
via its N-terminus. Interacts with HIPK1, which induces translocation from PML/POD/ND10 nuclear
bodies to chromatin and enhances association with HDAC1 (By similarity). The non-phosphorylated
form binds to PAX3, PAX7, DEK, HDAC1, HDAC2, HDAC3, acetylated histone H4 and histones H2A, H2B,
H3 and H4. Interacts with SPOP. Part of a complex consisting of DAXX, CUL3 and SPOP. Interacts
with CBP; the interaction is dependent the sumoylation of CBP and suppresses CBP transcriptional
activity via recruitment of HDAC2 (By similarity). Interacts with HCMV tegument phosphoprotein
pp71
Subcellular location: Nucleus. Cytoplasm. Note=Dispersed throughout the nucleoplasm, in
PML/POD/ND10 nuclear bodies, and in nucleoli. Colocalizes with a subset of interphase centromeres,
but is absent from mitotic centromeres. Detected in cytoplasmic punctate structures. Translocates
from the nucleus to the cytoplasm upon glucose deprivation or oxidative stress
Secondary accessions: O14747 O15141 O15208 Q9BWI3
Alternative splicing: 2 isoforms:  Q9UER7-1   Q9UER7-2   

Post-translational modifications:

  • Sumoylated1
  • Phosphorylated upon DNA damage, probably by ATM or ATR. Phosphorylated by HIPK1 upon glucose
    deprivation1
  • Polyubiquitinated; which is promoted by CUL3 and SPOP and results in proteasomal degradation1
  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins (3 alternative transcripts): 
    NP_001135441.1  NP_001135442.1  NP_001341.1  


    ENSEMBL proteins: 
    ENSP00000266000 ENSP00000363668 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Daxx)
    Human Recombinant Proteins from Abnova (DAXX)
                  OriGene Purified Recombinant Human Protein: DAXX 

    4 Gene Ontology (GO) cellular component terms (links to tree view):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000792 heterochromatin IEA--
    GO:0005634 nucleus IDA15572661
    GO:0005737 cytoplasm TAS15572661
    GO:0016605 PML body IEA--
    About this table

    Antibodies for DAXX: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of DAXX
    Sigma-Aldrich Antibody Arrays and Antibodies for DAXX
    R&D Systems Antibodies for DAXX
    Cell Signaling Technology (CST) Antibodies for DAXX 
    Antibodies from Abcam (Daxx), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (DAXX)
    Novus Biologicals Antibodies for DAXX

    Assays for DAXX: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for DAXX

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro domain/family:
     IPR005012 Daxx


       GeneDecks  DAXX for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry Q9UER7

    ProtoNet protein and cluster: Q9UER7

    1 Blocks protein family: IPB005012 Daxx protein

    UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7
    Similarity: Belongs to the DAXX family

    Gene Function
    for DAXX

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (DAXX)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (DAXX)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NR_024517

                  Applied Biosystems Silencer® siRNAs for DAXX

                  Sigma-Aldrich siRNA for DAXX  
                         Sigma-Aldrich shRNA Panels and shRNA for DAXX  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001141969
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001141969
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001141969 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_001141970

    UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7
    Function: Proposed to mediate activation of the JNK pathway and apoptosis via MAP3K5 in response to
    signaling from TNFRSF6 and TGFBR2. Interaction with HSPB1/HSP27 may prevent interaction with
    TNFRSF6 and MAP3K5 and block DAXX-mediated apoptosis. In contrast, in lymphoid cells JNC
    activation and TNFRSF6-mediated apoptosis may not involve DAXX. Seems to regulate transcription in
    PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis
    thereby. Down-regulates basal and activated transcription. Seems to act as a transcriptional
    co-repressor and inhibits PAX3 and ETS1 through direct protein-protein interaction. Modulates PAX5
    activity. Its transcription repressor activity is modulated by recruiting it to subnuclear
    compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and
    PML, respectively
    Induction: Upon mitogenic stimulation by concanavalin A

    Genatlas biochemistry entry for DAXX:
    murine Daxx homolog,120kDa,with a dominant transcript ubiquitously expressed,a truncated transcript
    in placenta and pancreas,and an extended transcript in heart and skeletal muscle,binding to FAS
    (APT1),enhancing Fas-mediated apoptosis through the JNK signal transduction
    pathway,alternatively,potential regulator of FAS-induced apoptosis from nuclear oncogenic domains
    PODs in which it colocalizes with PML.

    6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Daxx):

    cellularembryogenesisgrowth/sizelethality-prenatal/perinatalnervous system
    normal

    5/6 Gene Ontology (GO) molecular function terms (links to tree view) (see all 6 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005057 receptor signaling protein activity TAS9215629
    GO:0016564 transcription repressor activity IEA--
    GO:0031072 heat shock protein binding TAS15572661
    GO:0042802 identical protein binding IPI10698492
    GO:0047485 protein N-terminus binding IPI15572661
    About this table

    Pathways & Interactions
    for DAXX

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    4 Invitrogen iPath™ Online BioAtlas - Pathways for DAXX (Maps provided by GeneGo):
     Cytoplasm/mitochondrial transport of proapoptotic proteins Bid, Bmf and Bim
     Putative SUMO-1 pathway
     FAS signaling cascades. Part 1
     JNK pathway

       GeneDecks  DAXX for the pathways selected above  
    About GeneDecksing

    4 Millipore Pathways for DAXX
     Proteolysis Putative SUMO-1 pathway
     Apoptosis and survival FAS signaling cascades
     Signal transduction JNK pathway
     DNA damage Role of SUMO in p53 regulation

       GeneDecks  DAXX for the pathways selected above  
    About GeneDecksing

    5 Sigma-Aldrich "Your Favorite Gene" Pathways for  DAXX  (Your Favorite Gene powered by Ingenuity) 
     Induction of Apoptosis by HIV1
     Death Receptor Signaling
     Molecular Mechanisms of Cancer
     p38 MAPK Signaling
     SAPK/JNK Signaling

       GeneDecks  DAXX for the pathways selected above  
    About GeneDecksing

    2 Cell Signaling Technology (CST) Pathways for DAXX: 
     Death Receptor Signaling
     SAPK/JNK Signaling Cascades

       GeneDecks  DAXX for the pathways selected above  
    About GeneDecksing

    2 Kegg Pathways  (Kegg details for DAXX):
     hsa04010 MAPK signaling pathway
     hsa05014 Amyotrophic lateral sclerosis (ALS)

       GeneDecks  DAXX for the pathways selected above  
    About GeneDecksing
     Gene Network CentralTM Interacting Genes and Proteins Network for  DAXX 


    5/63 Interacting proteins for DAXX (ENSP000003636683 Q9UER71, 2) via UniProtKB, MINT, and/or STRING (see all 63 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    RASSF1Q9NS232STRING (score=.854) MINT-6801600 MINT-6801769 MINT-6801621 MINT-6801754 MINT-6801643 MINT-6801545 MINT-6801679 MINT-6801730 MINT-6801578
    FASP254451STRING (score=.987) EBI-77321, EBI-494743
    HDAC1Q135471STRING (score=.854) EBI-77321, EBI-301834
    HDAC2Q927691STRING (score=.857) EBI-77321, EBI-301821
    MAP3K5Q996831STRING (score=.978) EBI-77321, EBI-476263
    About this table

    5/8 Gene Ontology (GO) biological process terms (links to tree view) (see all 8 ):

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000281 cytokinesis after mitosis IEA--
    GO:0006350 transcription IEA--
    GO:0006915 apoptosis TAS15572661
    GO:0007257 activation of JUN kinase activity TAS9215629
    GO:0008625 induction of apoptosis via death domain receptors TAS9215629
    About this table

    Drugs & Compounds
    for DAXX

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for DAXX
    3 Novoseek chemical compound relationships for DAXX gene
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    lysine 30.65 4 16475184 (1)
    oligonucleotide 0.08 1 16088932 (1)
    glucose 0.00 19 12968034 (7), 15128734 (3), 14505347 (2), 18932217 (1) (see all 6)
    About this table


    Transcripts
    for DAXX

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (DAXX)
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (DAXX)
                   OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 4): NR_024517

                  Sigma-Aldrich siRNA for DAXX  
                         Sigma-Aldrich shRNA Panels and shRNA for DAXX  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_001141969  NM_001141970  NM_001350  

    REFSEQ mRNAs for DAXX gene (3 alternative transcripts): 

    NM_001141969.1   NM_001141970.1   NM_001350.4   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_001141969  NM_001141970  NM_001350  

                   OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001141969
                                     Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001141969
                                     untagged cDNA clones in CMV expression vector (see all 3): NM_001141969 

    Additional cDNA sequence: 

    AB209493.1 AF006041.1 AF015956.2 AF039136.1 AF050179.1 AF097742.1 AK223404.1 AK292187.1 
    AK303767.1 AK303854.1 AK313034.1 BC073776.1 BC109073.1 BC109074.1 CR457085.1 

    22 DOTS entries:

    DT.95315871  DT.418007  DT.100825272  DT.95250586  DT.121367046  DT.95340814  DT.100825267  DT.121367044 
    DT.100825274  DT.91657181  DT.92449848  DT.100825275  DT.121367021  DT.91883192  DT.92449851  DT.95340809 
    DT.100040497  DT.100042345  DT.100825271  DT.121367065  DT.92449856  DT.100825277 

    24/396 AceView cDNA sequences (see all 396 ):

    CR457085 AA807723 AU280019 AI277657 BM787247 BG105701 T36090 BU736840 
    AI186376 AW173049 AA383223 AW248825 AA962584 BM786433 BM997178 Z41479 
    CA426182 AW513420 AA308321 AI753509 CB160445 AI272267 BU164799 BQ420609 

    highest scoring ESTs for DAXX:

    AB015051 AA085057 AA312767 AA356615 AF006041 AF039136 AF050179 AI879303 AL048781 AL517256 

    Unigene Cluster for DAXX:

    Death-domain associated protein
    Hs.336916  [show with all ESTs]
    Unigene Representative Sequence: AB209493


    GeneLoc Exon Structure

    2 Ensembl transcripts including schematic representations:
    ENST00000266000  ENST00000374542  

    Expression
    for DAXX

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    DAXX expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for DAXX

    1 / 2 / 3

    6 probe-sets matching DAXX gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    41161_at2, 3 U95-A 3 1.00 0.33 0.96 1.11 AB015051 1.00 1.00 1.00 1
    1754_at2, 3 U95-A 3 1.00 0.33 0.85 0.89 AF006041 0.80 1.00 0.91 1

    		201763_s_at2, 3 U133-A 3 1.00 0.33 -- -- NM_001350 0.60 1.00 0.82 1

    		216038_x_at2, 3 U133-A 3 0.64 0.43 -- -- BE965715 0.20 1.00 0.72 1

    		201763_s_at2 U133Plus2 3 1.00 0.33 -- -- -- -- -- -- --

    		216038_x_at2 U133Plus2 3 0.64 0.43 -- -- -- -- -- -- --
    GeneDecks  DAXX for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: GCCTGGTGAC

    SOURCE GeneReport for Unigene cluster: Hs.336916

    Expression variation in blood from EXPOLDB for DAXX

    UniProtKB/Swiss-Prot: DAXX_HUMAN, Q9UER7
    Tissue specificity: Ubiquitous

    Orthologs
    for DAXX

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for DAXX gene from 5/8 species (see all 8 )
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    dog
    (Canis familiaris)    		 DAXX1   -- death-domain associated protein 90.54(n)
    90.59(a)    		 474873  XM_532108.2  XP_532108.2 
    chimpanzee
    (Pan troglodytes)    		 DAXX1   -- death-domain associated protein 99.86(n)
    99.86(a)    		 462613  XM_001170797.1  XP_001170797.1 
    cow
    (Bos taurus)    		 DAXX1   -- death-domain associated protein 88.57(n)
    86.34(a)    		 504336  NM_001075155.1  NP_001068623.1 
    rat
    (Rattus norvegicus)    		 Daxx1   -- death-domain associated protein 78.01(n)
    74.9(a)    		 140926  NM_080891.1  NP_543167.1 
    mouse
    (Mus musculus)    		 Daxx1, 5 17 (17.00 cM)5
    		 Fas death domain-associated protein1, 5 78.93(n)1
    73.42(a)1    		 131631  NM_007829.31  NP_031855.31 
     AF0060405  AF1009565  (see all 25)
    About this table        Species with no ortholog for DAXX

    ENSEMBL Gene Tree for DAXX

    Paralogs
    for DAXX

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    		  --

    SNPs/Variants
    for DAXX

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/15 NCBI SNPs in DAXX are shown (see all 15 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 44)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 6 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs10592311,2
    		A,C,F,H33396249(-) AAATAT/CGCAAT 1 Y/Y syn114Minor allele frequency- C:0.25EA EU WA NS MN NA 2964
    rs22398391,2
    		A,C,F,H33396053(-) TGGGGG/TAGCAT 1 -- int110Minor allele frequency- T:0.20EU EA WA NS MN 1096
    rs31300181,2
    		A,C33398380(-) CGGTGC/TGGGGG 1 -- int10--------
    rs69022911,2
    		A,C33398249(+) CCATAG/TTTCAC 1 -- int10--------
    rs22696101,2
    		C33397913(-) CCCCCC/GCCCAC 1 -- int1 trp30--------
    rs617376941,2
    		--33396263(+) GATGAA/GCTCAT 2 V/L V/F mis10--------
    --
    rs617572021,2
    		--33397121(+) TGAGTA/GGGCCT 1 H/Y mis10--------
    --
    rs344360301,2
    		--33396924(+) GCCGG-/TATCTC 1 I/N fra10--------
    --
    rs127200951,2
    		--33397224(-) GCCTCA/GGCGGA 1 S/S syn1 ese30--------
    --
    rs617485921,2
    		--33395482(+) AGTAAC/TGATGG 1 S/S syn10--------
    About this table

    HapMap Linkage Disequilibrium images for DAXX (up to first 250kb)

    Disorders & Mutations
    for DAXX

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 603186

    10/12 Novoseek disease relationships for DAXX gene (see all 12 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    promyelocytic leukemia 80.22 13 17942542 (2), 12953102 (2), 12186918 (1), 14990586 (1) (see all 9)
    alpha-thalassemia 43.74 1 16406523 (1)
    prostatic adenocarcinoma 24.70 1 12968034 (1)
    herpes simplex 23.76 1 16603511 (1)
    leukemia 17.81 7 17306074 (2), 11703323 (1), 16331268 (1), 16406523 (1) (see all 5)
    mental retardation 13.55 3 14990586 (1), 16406523 (1)
    tumors 8.74 5 16810318 (1), 14761963 (1), 16982744 (1)
    shock 4.58 2 17688194 (1)
    necrosis 0.00 1 14761963 (1)
    cancer 0.00 1 17938171 (1)
    About this table

    1 PharmGKB disease relationship for DAXX gene
    Disease PharmGKB Relations PubMed IDs for articles supporting these relationships
    Leukemia, Lymphocytic, Acute, L1FA  GN  12086872
    About this table

    Human Genome Epidemiology Navigator: DAXX (1 document)

    Medical News
    for DAXX

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for DAXX

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		10/169 PubMed articles for DAXX gene (see all 169 ):

    Search for DAXX

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DAXX

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 1616 HGNC: 2681 AceView: DAXX Ensembl:ENSG00000204209 euGenes: HUgn1616
    ECgene: DAXX H-InvDB: DAXX

    Other Databases showing DAXX

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing DAXX

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    ATLAS Chromosomes in Cancer entry for DAXX Genetics and Cytogenetics in Oncology and Haematology

    Licensable Technologies
    for DAXX

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for DAXX

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for DAXX:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for DAXX-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for DAXX Antibodies for DAXX
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for DAXX Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
     Antibodies   Primer Pairs  
     Cell Culture Products   ELISAs  
     Flow Cytometry Kits   Protease Activity Assays & Reagents  
     Cell Selection/Detection Kits & Reagents   ELISA/Assay Development Kits & Reagents  
     Multiplex/Array Assay Kits & Reagents   ELISpot Kits & Development Modules  
     Recombinant & Natural Proteins  

     Recombinant Proteins (DAXX)
     Antibodies (DAXX)
     Chimera RNAi (DAXX)
     Custom Service for Mouse Mab
     Custom Service for Rabbit Pab from Full-length Protein
      
     Antibodies & Assays for DAXX 

     Recombinant Proteins
    (Daxx)
     Antibodies (Daxx)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for DAXX




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Antibodies for DAXX

    GeneCards Homepage    -    Last full update: 2 Jul 2009        Incremental update: 13 Oct 2009

    Random Gene From GIFtS : about GIFtS

    Gene Index:   3   5   A   B   C   D   E   F   G   H   I   J   K   L   M   N   O   P   Q   R   S   T   U   V   W   X   Y   Z

    Developed at the Crown Human Genome Center & Weizmann Institute of Science



    The GeneCards Human Gene Database: Copyright © 1996-2009, Weizmann Institute of Science. All Rights Reserved.
    DAXX Gene at Home site.
    Version 2.41.1
    server5.xennexinc.com