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Aliases for DAW1 Gene

Aliases for DAW1 Gene

  • Dynein Assembly Factor With WD Repeats 1 2 3 5
  • Outer Row Dynein Assembly Protein 16 Homolog 3 4
  • WD Repeat-Containing Protein 69 3 4
  • WD Repeat Domain 69 2 3
  • WDR69 3 4
  • Outer Row Dynein Assembly 16 Homolog (Chlamydomonas) 2
  • Dynein Assembly Factor With WDR Repeat Domains 1 3
  • Testis Tissue Sperm-Binding Protein Li 93mP 3
  • Outer Row Dynein Assembly 16 Homolog 3
  • ODA16 3

External Ids for DAW1 Gene

Previous HGNC Symbols for DAW1 Gene

  • WDR69

Previous GeneCards Identifiers for DAW1 Gene

  • GC02P228736

Summaries for DAW1 Gene

GeneCards Summary for DAW1 Gene

DAW1 (Dynein Assembly Factor With WD Repeats 1) is a Protein Coding gene. An important paralog of this gene is APAF1.

UniProtKB/Swiss-Prot for DAW1 Gene

  • May play a role in axonemal outer row dynein assembly.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAW1 Gene

Genomics for DAW1 Gene

Regulatory Elements for DAW1 Gene

Enhancers for DAW1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G227847 1.4 FANTOM5 ENCODE dbSUPER 22.6 -22.2 -22154 2.2 RELA EGR1 CBX5 EED ETV6 RELB IKZF2 CREM ZNF680 MTA2 DAW1 TDGF1P2 CCL20 GC02P227844 GC02M227848
GH02G227862 1.4 FANTOM5 Ensembl ENCODE 10.3 -7.6 -7607 2.5 CTCF SAP130 JUN CEBPG ZNF644 HBP1 RAD21 TEAD3 CTBP1 ZNF143 DAW1 GC02M227862 GC02M227848
GH02G227839 1.2 FANTOM5 Ensembl ENCODE 10.1 -31.2 -31171 0.6 KLF1 MTA2 NR2F1 NR3C1 GATAD2B EBF1 DPF2 RARA EED CEBPA CCL20 DAW1 AGFG1 GC02P227841 GC02P227817
GH02G227870 0.7 ENCODE 12.6 +0.0 6 2.0 JUN MAX RFX5 GATA2 POLR2A RCOR1 FOS RFX1 NRF1 CEBPB DAW1 ENSG00000272237
GH02G227875 0.6 ENCODE 12.3 +5.1 5076 1.5 JUN CEBPB SIN3A PLRG1 EP300 ATF2 JUND POLR3A TCF7L2 DAW1 CCL20 ENSG00000272237
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DAW1 on UCSC Golden Path with GeneCards custom track

Promoters for DAW1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000131489 546 401 HDAC2 RFX3 POLR2A GLIS1 NRF1 ZKSCAN8

Genomic Location for DAW1 Gene

227,871,054 bp from pter
227,924,347 bp from pter
53,294 bases
Plus strand

Genomic View for DAW1 Gene

Genes around DAW1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAW1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAW1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAW1 Gene

Proteins for DAW1 Gene

  • Protein details for DAW1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Dynein assembly factor with WDR repeat domains 1
    Protein Accession:
    Secondary Accessions:
    • Q6ZRY1
    • Q8N776

    Protein attributes for DAW1 Gene

    415 amino acids
    Molecular mass:
    45777 Da
    Quaternary structure:
    • Interacts with IFT46.

    Alternative splice isoforms for DAW1 Gene


neXtProt entry for DAW1 Gene

Post-translational modifications for DAW1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAW1 Gene

No data available for DME Specific Peptides for DAW1 Gene

Domains & Families for DAW1 Gene

Gene Families for DAW1 Gene

Suggested Antigen Peptide Sequences for DAW1 Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the WD repeat WDR69 family.
  • Belongs to the WD repeat WDR69 family.
genes like me logo Genes that share domains with DAW1: view

Function for DAW1 Gene

Molecular function for DAW1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in axonemal outer row dynein assembly.

Phenotypes for DAW1 Gene

genes like me logo Genes that share phenotypes with DAW1: view

Animal Model Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DAW1 Gene

Localization for DAW1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAW1 Gene

Cell projection, cilium.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAW1 gene
Compartment Confidence
nucleus 2
cytosol 2
cytoskeleton 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for DAW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005929 cilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with DAW1: view

Pathways & Interactions for DAW1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DAW1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007368 determination of left/right symmetry IEA --
GO:0007507 heart development IEA --
genes like me logo Genes that share ontologies with DAW1: view

No data available for Pathways by source and SIGNOR curated interactions for DAW1 Gene

Drugs & Compounds for DAW1 Gene

No Compound Related Data Available

Transcripts for DAW1 Gene

Unigene Clusters for DAW1 Gene

Dynein assembly factor with WDR repeat domains 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAW1 Gene

No ASD Table

Relevant External Links for DAW1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DAW1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DAW1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAW1 Gene

This gene is overexpressed in Testis (x20.1), Brain - Nucleus accumbens (basal ganglia) (x5.2), and Brain - Caudate (basal ganglia) (x4.4).

Protein differential expression in normal tissues from HIPED for DAW1 Gene

This gene is overexpressed in Testis (37.5) and Heart (21.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DAW1 Gene

Protein tissue co-expression partners for DAW1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DAW1 Gene:


SOURCE GeneReport for Unigene cluster for DAW1 Gene:

genes like me logo Genes that share expression patterns with DAW1: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAW1 Gene

Orthologs for DAW1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DAW1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia WDR69 34 35
  • 99.36 (n)
(Bos Taurus)
Mammalia DAW1 34 35
  • 90.36 (n)
(Canis familiaris)
Mammalia DAW1 34 35
  • 89.88 (n)
(Mus musculus)
Mammalia Daw1 35
  • 89 (a)
(Monodelphis domestica)
Mammalia DAW1 35
  • 86 (a)
(Rattus norvegicus)
Mammalia Daw1 34
  • 84.42 (n)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 84 (a)
-- 35
  • 84 (a)
(Gallus gallus)
Aves WDR69 34
  • 76.89 (n)
DAW1 35
  • 75 (a)
(Anolis carolinensis)
Reptilia DAW1 35
  • 74 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia daw1 34
  • 73.09 (n)
MGC76247 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.12681 34
(Danio rerio)
Actinopterygii daw1 34 35
  • 67.82 (n)
Dr.15604 34
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.2611 34
fruit fly
(Drosophila melanogaster)
Insecta CG7568 34 35
  • 51.49 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009574 34
  • 31.04 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes RSA4 35
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9620 35
  • 67 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4284 34
Species where no ortholog for DAW1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DAW1 Gene

Gene Tree for DAW1 (if available)
Gene Tree for DAW1 (if available)

Paralogs for DAW1 Gene

Variants for DAW1 Gene

Sequence variations from dbSNP and Humsavar for DAW1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs113776284 A breast cancer sample 227,893,863(+) GAACA(C/T)GCTGG nc-transcript-variant, reference, missense, utr-variant-5-prime
rs1000009704 -- 227,886,551(+) GGCAG(A/G)GGTTG intron-variant
rs1000049489 -- 227,891,342(+) ATTTT(C/T)AGCAG intron-variant
rs1000161202 -- 227,897,832(+) TTAAC(A/G)TAATT intron-variant
rs1000250164 -- 227,876,189(+) TAATT(G/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAW1 Gene

Variant ID Type Subtype PubMed ID
dgv2165n106 CNV duplication 24896259
nsv10221 CNV loss 18304495
nsv1076505 CNV duplication 25765185
nsv1149946 CNV duplication 26484159
nsv3192 CNV insertion 18451855
nsv518157 CNV loss 19592680
nsv834562 CNV gain 17160897

Variation tolerance for DAW1 Gene

Residual Variation Intolerance Score: 88.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.14; 84.67% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAW1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAW1 Gene

Disorders for DAW1 Gene

Relevant External Links for DAW1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DAW1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DAW1 Gene

Publications for DAW1 Gene

  1. A unified taxonomy for ciliary dyneins. (PMID: 21953912) Hom E.F. … King S.M. (Cytoskeleton (Hoboken) 2011) 2 3 64
  2. Oda16/Wdr69 is essential for axonemal dynein assembly and ciliary motility during zebrafish embryogenesis. (PMID: 20568242) Gao C. … Mitchell D.R. (Dev. Dyn. 2010) 2 3 64
  3. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for DAW1 Gene

Sources for DAW1 Gene

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