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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DARS Gene

protein-coding   GIFtS: 63
GCID: GC02M136686

aspartyl-tRNA synthetase
 Explore 7 diseases affiliated with
DARS via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DARS    

Aliases
for DARS gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Aspartyl-TRNA Synthetase1 2 3     Aspartate--TRNA Ligase, Cytoplasmic2
Cell Proliferation-Inducing Gene 40 Protein2 3     Aspartyl-TRNA Synthetase, Cytoplasmic2
EC 6.1.1.123 8     Cell Proliferation-Inducing Protein 402
AspRS3     AspRS3
Aspartate TRNA Ligase 1, Cytoplasmic2     

External Ids:    HGNC: 26781   Entrez Gene: 16152   Ensembl: ENSG000001158667   OMIM: 6030845   UniProtKB: P148683   

Export aliases for DARS gene to outside databases

Previous GC identifers: GC02M134319 GC02M134961 GC02M136875 GC02M136497 GC02M136380 GC02M128656


Summaries
for DARS gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DARS:
Aspartyl-tRNA synthetase (DARS) is part of a multienzyme complex of aminoacyl-tRNA synthetases. Aspartyl-tRNA
synthetase charges its cognate tRNA with aspartate during protein biosynthesis. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: SYDC_HUMAN, P14868
Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid
(AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA

Gene Wiki entry for DARS


Genomic Views
for DARS gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NC_018913.1  NT_022135.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DARS gene promoter:
         STAT5B   STAT1   STAT4   STAT6   STAT1beta   STAT5A   STAT1alpha   STAT2   STAT3   POU2F1c   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DARS promoter sequence
   Search SABiosciences Chromatin IP Primers for DARS

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DARS


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.3   Ensembl cytogenetic band:  2q21.3   HGNC cytogenetic band: 2q21.3

DARS Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DARS gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M136686:  view genomic region     (about GC identifiers)

Start:
 136,664,247 bp from pter      End:
 136,743,670 bp from pter
Size:
 79,424 bases      Orientation:
 minus strand

Proteins
for DARS gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: SYDC_HUMAN, P14868 (See protein sequence)
Recommended Name: Aspartate--tRNA ligase, cytoplasmic  
Size: 501 amino acids; 57136 Da
Subunit: Homodimer; also part of a multisubunit complex that groups AIMP1, AIMP2, EEF1A1 and tRNA ligases for Arg, Asp,
Glu, Gln, Ile, Leu, Lys, Met and Pro
Subcellular location: Cytoplasm
Secondary accessions: A8K3J2 D3DP77 Q2TNI3 Q32Q69 Q53HV4 Q53YC5 Q9BW52

Explore the universe of human proteins at neXtProt for DARS: NX_P14868

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P14868

    • 4/10 DME Specific Peptides for DARS (P14868) (see all 10)
     QSPQLYK  CFLVLRQ  DTRLDNR  FMRGEEI 

    DARS Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001340.2  
    ENSEMBL proteins: 
     ENSP00000264161   ENSP00000387508   ENSP00000389867   ENSP00000397616   ENSP00000388801  
     ENSP00000404445   ENSP00000444192  
    Reactome Protein details: P14868
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: DARS
    OriGene Protein Over-expression Lysate: DARS
    OriGene Custom Protein Services for DARS 
    GenScript Custom Purified and Recombinant Proteins Services for DARS
    Novus Biologicals DARS Proteins
    Novus Biologicals DARS Lysates
    Browse Sino Biological Recombinant Proteins
    ProSpec Recombinant Protein for DARS
    Uscn Proteins for DARS

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005625soluble fraction ----
    GO:0005737cytoplasm IDA--
    GO:0005829cytosol TAS--


    DARS for ontologies           About GeneDecksing



    DARS Antibody Products: 
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    Assay Products for DARS: 
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    Uscn ELISAs and CLIAs for DARS

    Protein Domains /
    Families
    for DARS gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DARS for domains           About GeneDecksing

    5/7 InterPro domains/families (see all 7):
     IPR004523 Asp-tRNA_synthase
     IPR006195 aa-tRNA-synth_II
     IPR004364 aa-tRNA-synt_II
     IPR012340 NA-bd_OB-fold
     IPR004365 NA-bd_OB_tRNA-helicase

    Graphical View of Domain Structure for InterPro Entry P14868

    ProtoNet protein and cluster: P14868

    3 Blocks protein families:
    IPB002312 Aspartyl-tRNA synthetase signature
    IPB004364 tRNA synthetase
    IPB004365 OB-fold nucleic acid binding domain


    UniProtKB/Swiss-Prot: SYDC_HUMAN, P14868
    Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family


    Function
    for DARS gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: SYDC_HUMAN, P14868
    Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid
    (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA
    Catalytic activity: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)

    Enzyme Number (IUBMB): EC 6.1.1.121 2

    miRNA
    Products:            		 OriGene 3'-UTR Clone: DARS
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DARS
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate DARS (see all 11):
    hsa-miR-3685 hsa-miR-448 hsa-miR-657 hsa-miR-3617 hsa-miR-4282 hsa-miR-374c hsa-miR-641 hsa-miR-655
    SwitchGear 3'UTR luciferase reporter plasmid: DARS 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DARS (see all 7)
    OriGene shRNA RFP: DARS
    OriGene siRNA: DARS
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DARS

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DARS

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DARS (see all 4)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DARS
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DARS (NM_001349)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DARS
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DARS 

    Cell Line
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    Search LifeMap BioReagents cell lines for DARS

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DARS

    Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0004046aminoacylase activity TAS8449960
    GO:0004815aspartate-tRNA ligase activity IEA--
    GO:0005515protein binding IPI19380743
    GO:0005524ATP binding IEA--


    DARS for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for DARS:
     Decreased POU5F1-GFP protein e  Decreased viability 


    Pathways & Interactions
    for DARS gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1tRNA Aminoacylation
    		tRNA Aminoacylation1.00
    		Aminoacyl-tRNA biosynthesis0.54
    		Cytosolic tRNA aminoacylation0.57
    2Generic Transcription Pathway
    		Gene Expression0.46
    3alanine degradation III
    		Alanine and aspartate metabolism0.08

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 BioSystems Pathway for DARS 
        Alanine and aspartate metabolism

    3        Reactome Pathways for DARS
        Cytosolic tRNA aminoacylation
    tRNA Aminoacylation
    Gene Expression


    1         Kegg Pathway  (Kegg details for DARS):
        Aminoacyl-tRNA biosynthesis


    DARS for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DARS

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/134 Interacting proteins for DARS (P148681, 2, 3 ENSP000002641614) via UniProtKB, MINT, STRING, and/or I2D (see all 134)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R3Q925692, 3MINT-8266194 I2D: score=2 
    AIMP2Q131552, 3, ENSP000002230294MINT-8258842 MINT-66813 I2D: score=5 STRING: ENSP00000223029
    GRB2P629931, 3, ENSP000003390074EBI-358730,EBI-401755 I2D: score=1 STRING: ENSP00000339007
    HSP90AA1P079002, 3, ENSP000003351534MINT-17656 I2D: score=4 STRING: ENSP00000335153
    EEF1A1P681043, ENSP000003300544I2D: score=4 STRING: ENSP00000330054
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006412translation TAS8449960
    GO:0006418tRNA aminoacylation for protein translation TAS--
    GO:0006422aspartyl-tRNA aminoacylation IEA--
    GO:0006461protein complex assembly TAS8449960
    GO:0010467gene expression TAS--


    DARS for ontologies           About GeneDecksing



    Drugs & Compounds
    for DARS gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DARS for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DARS

    6 HMDB Compounds for DARS    About this table
    CompoundSynonyms CAS #PubMed Ids
    Adenosine monophosphate5'-AMP (see all 28)61-19-8--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    L-Aspartic acid(+)-Aspartate (see all 41)56-84-8--
    Phosphoric acidacide phosphorique (FRENCH) (see all 20)7664-38-2--
    Pyrophosphate(4-)Diphosphoric acid ion (see all 10)14000-31-8--
    Ureidosuccinic acid2-Ureidobutanedioic acid (see all 16)13184-27-5--

    1 DrugBank Compound for DARS    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    L-Aspartic Acid(+)-Aspartic acid (see all 23)56-84-8target--16597625 10562565 17139284 17016423 8313877

    10 Novoseek chemical compound relationships for DARS gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    aspartyl adenylate 96.1 2 15582453 (1), 16574659 (1)
    aminoacyl-trna 90 3 9548745 (1), 15779907 (1), 9878398 (1)
    trna(asp) 89 6 8841554 (1), 17690095 (1), 16675303 (1), 12766171 (1)
    trna 79.7 51 16800632 (4), 19443655 (3), 8449960 (3), 7806521 (2) (see all 12)
    anticodon 65.4 1 12766171 (1)
    aspartate 57.8 8 17690095 (1), 9480772 (1), 17964262 (1), 16408313 (1)
    asparagine 43.6 4 9480772 (1), 17964262 (1), 16408313 (1)
    biotin 30.2 1 12821332 (1)
    magnesium 29.7 4 16774919 (3)
    atp 20.1 7 16408313 (2), 8841554 (1), 16774919 (1)

    Search CenterWatch for drugs/clinical trials and news about DARS / SYDC 

    Transcripts
    for DARS gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DARS gene: 
    NM_001349.2  

    Unigene Cluster for DARS:

    Aspartyl-tRNA synthetase
    Hs.503787  [show with all ESTs]
    Unigene Representative Sequence: NM_001349
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000264161(uc002tux.1 uc010fnj.1) ENST00000478212 ENST00000489964
    ENST00000422708 ENST00000491481 ENST00000441323 ENST00000456565 ENST00000449218
    ENST00000435076 ENST00000463008 ENST00000474184 ENST00000537273

    miRNA
    Products:             		 OriGene 3'-UTR Clone: DARS
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DARS
    8/11 QIAGEN miScript miRNA Assays for microRNAs that regulate DARS (see all 11):
    hsa-miR-3685 hsa-miR-448 hsa-miR-657 hsa-miR-3617 hsa-miR-4282 hsa-miR-374c hsa-miR-641 hsa-miR-655
    SwitchGear 3'UTR luciferase reporter plasmid: DARS 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DARS (see all 7)
    OriGene shRNA RFP: DARS
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AK129521.1 AK222476.1 AK290607.1 AY762100.1 BC000629.2 BC107749.1 BT006710.1 CR749809.1 
    J05032.1 

    22 DOTS entries:

    DT.40312213  DT.452634  DT.100681335  DT.120973165  DT.100681326  DT.95150459  DT.95150452  DT.120973169 
    DT.75141515  DT.86855627  DT.92448148  DT.92448153  DT.95153346  DT.120973163  DT.75158530  DT.95196519 
    DT.91743855  DT.95150457  DT.95150458  DT.100681332  DT.100682068  DT.97859714 

    24/401 AceView cDNA sequences (see all 401):

    CA865450 AU279963 CR619925 BQ215061 BG944720 BQ953818 W94645 BM450831 
    BM800514 BQ187424 BQ897750 BM667628 AU123430 AU119173 N24843 BM829046 
    CR598543 BG654591 BQ006775 BM836777 AU122896 BP378588 BU160733 AL047360 

    GeneLoc Exon Structure


    Expression
    for DARS gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DARS expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GAAAATTAAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DARS expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyMetanephric MesenchymeMetanephric Mesenchyme CellsKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DARS Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DARS

    SOURCE GeneReport for Unigene cluster: Hs.503787
        SABiosciences Custom PCR Arrays for DARS
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DARS

    Orthologs
    for DARS gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DARS gene from 9/40 species (see all 40)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DARS1 aspartyl-tRNA synthetase 82.17(n)
    89.82(a)    		   424296  NM_001006528.1  NP_001006528.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DARS6
    		 --
    		 90(a)
    		 1 ↔ 1
    		 1(96800055-96850914)
    African clawed frog
    (Xenopus laevis)    		 Amphibia dars-prov2 aspartyl-tRNA synthetase 79.7(n)    BC042227.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii wufc17a112 wufc17a11 77.56(n)   324025  CK400129.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Aats-asp1 , 3 aspartyl-tRNA aminoacylation aspartate-tRNA
    ligase3
    Aspartyl-tRNA synthetase1    		 68(a)3
    62.85(n)1
    67.67(a)1    		   49D73
    364201  NM_057261.31  NP_476609.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea drs-13
    dars-11    		 Aspartyl-tRNA synthetase3
    Protein DARS-11    		 63(a)3
    61.65(n)1
    63.65(a)1    		   III(9561037-9562925)3
    1763341  NM_066688.21  NP_499089.11 
    baker's yeast
    (Saccharomyces cerevisiae)    		 Saccharomycetes DPS1(YLL018C)4
    DPS11    		 Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric more4
    Dps1p1    		 57.74(n)1
    57.81(a)1    		   12(111575-109902)4
    8506431, 4  NP_013083.11, 4 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons AT4G311801 aspartyl-tRNA synthetase 55.85(n)
    52.98(a)    		   829246  NM_119268.4  NP_194847.3 
    rice
    (Oryza sativa)    		 Liliopsida Os.127162 Oryza sativa (japonica cultivar-group) cDNA cloneJ more 74.75(n)    AK100516.1 


    ENSEMBL Gene Tree for DARS (if available)
    TreeFam Gene Tree for DARS (if available) 

    Paralogs
    for DARS gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DARS gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1135 NCBI SNPs in DARS are shown (see all 1135)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 2 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1839827791,2
    		--136663782(+) CCCTCA/GTATTT 1 -- ds50010--------
    rs1891052211,2
    		--136663883(+) CAACAC/TTTGTA 1 -- ds50010--------
    rs1455944561,2
    		C,--136663892(+) TAATA-/ATCTAG
                AGGGA     		1 -- ds50010--------
    rs2010714341,2
    		--136663897(+) ATCTA-/GAGGGAAA 1 -- ds50010--------
    rs1451090491,2
    		--136663944(+) TTTGAC/TGGATA 1 -- ds50010--------
    rs1815573431,2
    		--136663945(+) TTGACA/GGATAA 1 -- ds50010--------
    rs1857487811,2
    		--136664229(+) TGGCCA/GCAAAG 1 -- ds50010--------
    rs1904388231,2
    		--136664269(+) TTTTAC/TTGAAA 1 -- ut310--------
    rs759901691,2
    		C,F,--136664349(+) ACATAA/GTTTCT 1 -- ut311Minor allele frequency- G:0.02WA 118
    rs1389993101,2
    		--136664454(+) CTTATA/CTCAAT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DARS (136664247 - 136743670 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DARS: --

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DARS
    DNA2.0 Custom Variant and Variant Library Synthesis for DARS

    Disorders / Diseases
    for DARS gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DARS for disorders           About GeneDecksing

    OMIM gene information: 603084    OMIM disorders: --

    7 diseases for DARS:    About MalaCards
    alpers syndrome    episodic ataxia    appendicitis    prostate cancer
    ataxia    prostatitis    malaria


    Export disorders for DARS gene to outside databases

    Publications
    for DARS gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DARS gene, integrated from 9 sources (see all 83):
    (articles sorted by number of sources associating them with DARS)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. cDNA sequence, predicted primary structure, and evolving amphiphilic helix of human aspartyl-tRNA synthetase. (PubMed id 2674137)1, 2, 3 Jacobo-Molina A.... Yang D.C.H. (1989)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Structure of the N-terminal extension of human aspartyl-tRNA synthetase: implications for its biological function. (PubMed id 12824064)1, 9 Cheong H.K....Cheong C. (2003)
    4. Expression of human aspartyl-tRNA synthetase in Escherichia coli. Functional analysis of the N-terminal putative amphiphilic helix. (PubMed id 8449960)1, 9 Escalante C. and Yang D.C. (1993)
    5. Lysyl-tRNA synthetase interacts with EF1alpha, aspartyl-tRNA synthetase and p38 in vitro. (PubMed id 18029264)2, 9 Guzzo C.M. and Yang D.C.H. (2008)
    6. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PubMed id 15779907)1, 9 Bonnefond L....Sissler M. (2005)
    7. Mechanisms of the transfer of aminoacyl-tRNA from aminoacyl-tRNA synthetase to the elongation factor 1 alpha. (PubMed id 7806521)1, 9 Reed V.S....Yang D.C. (1994)
    8. Loss of a primordial identity element for a mammalian mitochondrial aminoacylation system. (PubMed id 16597625)7, 9 Fender A....Sissler M. (2006)
    9. Genetic dissection of protein-protein interactions in multi-tRNA synthetase complex. (PubMed id 10200289)1, 9 Rho S.B....Shiba K. (1999)
    10. Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. (PubMed id 9878398)1, 9 Quevillon S.... Mirande M. (1999)

    External Searches for DARS gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DARS gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1615 HGNC: 2678 AceView: DARS Ensembl:ENSG00000115866 euGenes: HUgn1615
    ECgene: DARS Kegg: 1615 H-InvDB: DARS

    Other Databases showing DARS gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DARS gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DARS Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DARS gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DARS gene:
    Search GeneIP for patents involving DARS

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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