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Aliases & Descriptions for DARS
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| AspRS 3 | | DKFZp781B11202 2 | | EC 6.1.1.12 3 | | MGC111579 2 |
| | | Descriptions |
|---|
| Aspartate--tRNA ligase 3 | | Cell proliferation-inducing gene 40 protein 3 | | aspartate tRNA ligase 1, cytoplasmic 2 | | aspartyl-tRNA synthetase 2 | | cell proliferation-inducing protein 40 2 |
|
| | Search outside databases for aliases for DARS genePrevious GC identifers: GC02M134319 GC02M134961 GC02M136686 GC02M136875 GC02M136497 |
Summaries for DARS(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for DARS: Aspartyl-tRNA synthetase (DARS) is part of a multienzyme complex of aminoacyl-tRNA synthetases. Aspartyl-tRNA synthetase charges its cognate tRNA with aspartate during protein biosynthesis. [provided by RefSeq] Gene Wiki entry for DARS |
Genomic Location for DARS
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the DARS gene 
Entrez Gene cytogenetic band: 2q21.3 Ensembl cytogenetic band: 2q21.3 HGNC cytogenetic band: 2q21.3DARS Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M136380:
(about GC identifiers)
Start:
|
136,380,724 bp from pter |
End:
|
136,459,692 bp from pter |
Size:
|
78,969 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000002.10 NT_022135.15
| Proteins for DARS
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: SYDC_HUMAN, P14868 (See
protein sequence)Recommended Name: Aspartyl-tRNA synthetase, cytoplasmic Size: 501 amino acids; 57136 Da
Subunit: Homodimer; also part of a multisubunit complex that groups tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro
Subcellular location: Cytoplasm
Secondary accessions: Q2TNI3 Q32Q69 Q53HV4 Q53YC5 Q9BW52Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001340.2
ENSEMBL proteins: ENSP00000264161
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for DARS: Assays for DARS: | Protein
Domains/ Families for DARS(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P14868
ProtoNet protein and cluster: P14868 3 Blocks protein families: IPB002312 Aspartyl-tRNA synthetase signature IPB004364 tRNA synthetase IPB004365 OB-fold nucleic acid binding domain
UniProtKB/Swiss-Prot: SYDC_HUMAN, P14868Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family | Gene Function for DARS
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001349
Applied Biosystems Silencer® siRNAs for DARS
Sigma-Aldrich siRNA for DARS  Sigma-Aldrich shRNA for DARS  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001349                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001349                                  untagged cDNA clone in CMV expression vector: NM_001349 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001349
UniProtKB/Swiss-Prot: SYDC_HUMAN, P14868Catalytic activity: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)Enzyme Number (IUBMB): EC 6.1.1.12 5/7 Gene Ontology (GO) molecular function terms (links to tree view) (see all 7
): About this table | Pathways & Interactions for DARS
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 3 Sigma-Aldrich "Your Favorite Gene" Pathways for DARS (Your Favorite Gene powered by Ingenuity) 
5/28 Interacting proteins for DARS (ENSP000002641613 P148681, 2) via UniProtKB, MINT, and/or STRING (see all 28
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for DARS(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for DARS 8 Novoseek chemical compound relationships for DARS gene
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| aspartyl adenylate |
95.69 |
2 |
15582453 (1), 16574659 (1) |
| trna(asp) |
89.57 |
6 |
8841554 (1), 17690095 (1), 16675303 (1), 12766171 (1) |
| aminoacyl-trna |
89.28 |
3 |
9548745 (1), 15779907 (1), 9878398 (1) |
| trna |
79.68 |
48 |
16800632 (4), 8449960 (3), 7806521 (2), 14729703 (2) (see all 11) |
| anticodon |
50.68 |
1 |
12766171 (1) |
| asparagine |
45.63 |
4 |
9480772 (1), 17964262 (1), 16408313 (1) |
| magnesium |
31.85 |
4 |
16774919 (3) |
| atp |
22.56 |
7 |
16408313 (2), 8841554 (1), 16774919 (1) |
About this table
|
Transcripts for DARS(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001349
Sigma-Aldrich siRNA for DARS  Sigma-Aldrich shRNA for DARS  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001349 REFSEQ mRNAs for DARS gene: NM_001349.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001349               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001349                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001349                                  untagged cDNA clone in CMV expression vector: NM_001349  Additional cDNA sequence: AK129521.1 AK222476.1 AK290607.1 AY762100.1 BC000629.2 BC107749.1 BT006710.1 CR598543.1 CR608647.1 CR619925.1 CR749809.1 J05032.1 22 DOTS entries: DT.40312213 DT.452634 DT.100681335 DT.120973165 DT.100681326 DT.95150459 DT.95150452 DT.120973169 DT.75141515 DT.86855627 DT.92448148 DT.95153346 DT.92448153 DT.120973163 DT.75158530 DT.95196519 DT.91743855 DT.95150457 DT.95150458 DT.100681332 DT.100682068 DT.97859714 24/401 AceView cDNA sequences (see all 401
):CB149392 BQ440736 BU196303 W94645 NM_001349 BQ670969 AU122896 BF797373 BQ215061 BM505379 CB151611 BQ638956 AK129521 CB141805 CB321795 BQ775537 W94607 BU167645 BI438834 BQ650959 BQ777748 CR608647 BQ049736 BQ897750
highest scoring ESTs for DARS:J05032 AI751951 AK129521 AL035868 AU120014 AU134609 AW860527 BC000629 BE540125 BE542878 Unigene Cluster for DARS: Aspartyl-tRNA synthetase Hs.503787 [show with all ESTs]Unigene Representative Sequence: NM_001349
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000264161
|
Expression for DARS
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| DARS expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for DARS
1 / 2 / 3 5 probe-sets matching DARS gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: GAAAATTAAC
SOURCE GeneReport for Unigene cluster: Hs.503787
Expression variation in blood from EXPOLDB for DARS |
Orthologs for DARS
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DARS gene from 5/25 species (see all 25
)
About this table Species with no ortholog for DARS
ENSEMBL Gene Tree for DARS | Paralogs for DARS(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for DARS gene
- NARS22 NARS2
|
SNPs/Variants for DARS(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for DARS (up to first 250kb)
|
Disorders & Mutations for DARS
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603084
1 PharmGKB disease relationship for DARS geneAbout this table
|
Medical News for DARS(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for DARS (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/50 PubMed articles for DARS gene (see all 50
):- cDNA sequence, predicted primary structure, and evolving amphiphilic helix of human aspartyl-tRNA synthetase. (PubMed id 2674137)2, 3, 4 Jacobo-Molina A.... Yang D.C.H. (1989)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Structure of the N-terminal extension of human aspartyl-tRNA synthetase: implications for its biological function. (PubMed id 12824064)1, 3 Cheong H.K....Cheong C. (2003)
- Expression of human aspartyl-tRNA synthetase in Escherichia coli. Functional analysis of the N-terminal putative amphiphilic helix. (PubMed id 8449960)1, 3 Escalante C. and Yang D.C. (1993)
- Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. (PubMed id 15779907)1, 3 Bonnefond L....Sissler M. (2005)
- Mechanisms of the transfer of aminoacyl-tRNA from aminoacyl-tRNA synthetase to the elongation factor 1 alpha. (PubMed id 7806521)1, 3 Reed V.S....Yang D.C. (1994)
- Genetic dissection of protein-protein interactions in multi-tRNA synthetase complex. (PubMed id 10200289)1, 3 Rho S.B....Shiba K. (1999)
- Macromolecular assemblage of aminoacyl-tRNA synthetases: identification of protein-protein interactions and characterization of a core protein. (PubMed id 9878398)1, 3 Quevillon S....Mirande M. (1999)
- Automated phosphoproteome analysis for cultured cancer cells by two- dimensional nanoLC-MS using a calcined titania/C18 biphasic column. (PubMed id 18187866)4 Imami K.... Ishihama Y. (2008)
- Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. (PubMed id 17220478)3 Tu L.C....Lin B. (2007)
|
Search for DARS
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DARS
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing DARS
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DARS(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for DARS(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for DARS:

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| | Recombinant Proteins (DARS) | | Antibodies (DARS) |
| | | Search Tocris compounds for DARS |
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Incremental update: 13 Oct 2009
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