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Aliases for DARS Gene

Aliases for DARS Gene

  • Aspartyl-TRNA Synthetase 4 2 3
  • Cell Proliferation-Inducing Gene 40 Protein 3 4
  • EC 6.1.1.12 4 63
  • ASPRS 3 4
  • HBSL 3 6
  • Aspartyl-TRNA Synthetase, Cytoplasmic 3
  • Aspartate TRNA Ligase 1, Cytoplasmic 3
  • Aspartate--TRNA Ligase, Cytoplasmic 3
  • Aspartate TRNA Ligase 1 2
  • Cytoplasmic 2

External Ids for DARS Gene

Previous GeneCards Identifiers for DARS Gene

  • GC02M134319
  • GC02M134961
  • GC02M136686
  • GC02M136875
  • GC02M136497
  • GC02M136380
  • GC02M128656

Summaries for DARS Gene

Entrez Gene Summary for DARS Gene

  • This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for DARS Gene

DARS (Aspartyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with DARS include hypomyelination with brainstem and spinal cord involvement and leg spasticity and spasticity. Among its related pathways are Gene Expression and tRNA Aminoacylation. GO annotations related to this gene include nucleic acid binding and aspartate-tRNA ligase activity.

UniProtKB/Swiss-Prot for DARS Gene

  • Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA

Gene Wiki entry for DARS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DARS Gene

Genomics for DARS Gene

Regulatory Elements for DARS Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DARS Gene

Start:
135,906,677 bp from pter
End:
135,986,100 bp from pter
Size:
79,424 bases
Orientation:
Minus strand

Genomic View for DARS Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DARS Gene

Proteins for DARS Gene

  • Protein details for DARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14868-SYDC_HUMAN
    Recommended name:
    Aspartate--tRNA ligase, cytoplasmic
    Protein Accession:
    P14868
    Secondary Accessions:
    • A8K3J2
    • D3DP77
    • Q2TNI3
    • Q32Q69
    • Q53HV4
    • Q53YC5
    • Q68CR9
    • Q9BW52

    Protein attributes for DARS Gene

    Size:
    501 amino acids
    Molecular mass:
    57136 Da
    Quaternary structure:
    • Homodimer; also part of a multisubunit complex that groups AIMP1, AIMP2, EEF1A1 and tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro

    Three dimensional structures from OCA and Proteopedia for DARS Gene

    Alternative splice isoforms for DARS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DARS Gene

Proteomics data for DARS Gene at MOPED

Post-translational modifications for DARS Gene

  • Ubiquitination at Lys103 and Lys330
  • Modification sites at PhosphoSitePlus

Other Protein References for DARS Gene

Domains for DARS Gene

Gene Families for DARS Gene

HGNC:
  • aaRS2 :Aminoacyl tRNA synthetases / Class II

Suggested Antigen Peptide Sequences for DARS Gene

Graphical View of Domain Structure for InterPro Entry

P14868

UniProtKB/Swiss-Prot:

SYDC_HUMAN :
  • P14868
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with DARS: view

Function for DARS Gene

Molecular function for DARS Gene

UniProtKB/Swiss-Prot CatalyticActivity: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)
UniProtKB/Swiss-Prot Function: Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA

Enzyme Numbers (IUBMB) for DARS Gene

Gene Ontology (GO) - Molecular Function for DARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003676 nucleic acid binding --
GO:0004046 aminoacylase activity TAS 8449960
GO:0004812 aminoacyl-tRNA ligase activity --
GO:0004815 aspartate-tRNA ligase activity IEA --
genes like me logo Genes that share ontologies with DARS: view

Phenotypes for DARS Gene

GenomeRNAi human phenotypes for DARS:
genes like me logo Genes that share phenotypes with DARS: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DARS Gene

Localization for DARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for DARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DARS Gene COMPARTMENTS Subcellular localization image for DARS gene
Compartment Confidence
cytosol 4
nucleus 2

Gene Ontology (GO) - Cellular Components for DARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0016020 membrane IDA 19946888
GO:0070062 extracellular exosome IDA 20458337
genes like me logo Genes that share ontologies with DARS: view

Pathways for DARS Gene

genes like me logo Genes that share pathways with DARS: view

Pathways by source for DARS Gene

1 BioSystems pathway for DARS Gene
1 KEGG pathway for DARS Gene

Gene Ontology (GO) - Biological Process for DARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006412 translation TAS 8449960
GO:0006418 tRNA aminoacylation for protein translation TAS --
GO:0006422 aspartyl-tRNA aminoacylation IEA --
GO:0006461 protein complex assembly TAS 8449960
GO:0010467 gene expression TAS --
genes like me logo Genes that share ontologies with DARS: view

Compounds for DARS Gene

(6) HMDB Compounds for DARS Gene

Compound Synonyms Cas Number PubMed IDs
Adenosine monophosphate
  • 5'-AMP
61-19-8
Adenosine triphosphate
  • 5'-(tetrahydrogen triphosphate) Adenosine
56-65-5
L-Aspartic acid
  • (+)-Aspartate
56-84-8
Phosphoric acid
  • acide phosphorique (FRENCH)
7664-38-2
Pyrophosphate
  • (4-)Diphosphoric acid ion
14000-31-8

(1) Drugbank Compounds for DARS Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
L-Aspartic Acid
  • (+)-Aspartic acid
56-84-8 target

(10) Novoseek inferred chemical compound relationships for DARS Gene

Compound -log(P) Hits PubMed IDs
aspartyl adenylate 96.1 2
aminoacyl-trna 90 3
trna(asp) 89 4
trna 79.7 22
anticodon 65.4 1
genes like me logo Genes that share compounds with DARS: view

Transcripts for DARS Gene

Unigene Clusters for DARS Gene

Aspartyl-tRNA synthetase:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DARS

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DARS Gene

No ASD Table

Relevant External Links for DARS Gene

GeneLoc Exon Structure for
DARS
ECgene alternative splicing isoforms for
DARS

Expression for DARS Gene

mRNA expression in normal human tissues for DARS Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DARS Gene

SOURCE GeneReport for Unigene cluster for DARS Gene Hs.503787

mRNA Expression by UniProt/SwissProt for DARS Gene

P14868-SYDC_HUMAN
Tissue specificity: Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporaal cortex and the frontal polar cortex. The cerebellum, cereral cortex, hippocampus, and lateral ventricle show preferential neuronal expression. Expression in the peripheral neurons is evident in the colon.
genes like me logo Genes that share expressions with DARS: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DARS Gene

Orthologs for DARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DARS Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DARS 35
  • 99.73 (n)
  • 99.6 (a)
DARS 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DARS 35
  • 93.21 (n)
  • 96.01 (a)
DARS 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DARS 35
  • 93.88 (n)
  • 97.41 (a)
DARS 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dars 35
  • 91.75 (n)
  • 96.01 (a)
Dars 16
Dars 36
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DARS 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DARS 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dars 35
  • 90.95 (n)
  • 95.61 (a)
chicken
(Gallus gallus)
Aves DARS 35
  • 82.17 (n)
  • 89.82 (a)
DARS 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DARS 36
  • 85 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia dars-prov 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dars 35
  • 77.71 (n)
  • 91.04 (a)
MGC76305 35
zebrafish
(Danio rerio)
Actinopterygii dars 35
  • 76.6 (n)
  • 85.63 (a)
dars 36
  • 78 (a)
OneToOne
wufc17a11 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005576 35
  • 60.13 (n)
  • 68.68 (a)
fruit fly
(Drosophila melanogaster)
Insecta Aats-asp 35
  • 62.92 (n)
  • 67.67 (a)
Aats-asp 36
  • 63 (a)
OneToOne
Aats-asp 37
  • 68 (a)
worm
(Caenorhabditis elegans)
Secernentea dars-1 35
  • 62.57 (n)
  • 64.58 (a)
dars-1 36
  • 60 (a)
OneToOne
drs-1 37
  • 63 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL039C 35
  • 55.47 (n)
  • 55.53 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPS1 35
  • 57.74 (n)
  • 57.81 (a)
DPS1 36
  • 52 (a)
OneToOne
DPS1 38
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03839g 35
  • 58.18 (n)
  • 57.64 (a)
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10065 35
soybean
(Glycine max)
eudicotyledons Gma.1067 35
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G31180 35
  • 55.85 (n)
  • 52.98 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.2597 35
corn
(Zea mays)
Liliopsida Zm.3547 35
rice
(Oryza sativa)
Liliopsida Os.12716 35
Os02g0686400 35
  • 55.71 (n)
  • 53.96 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14416 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07082 35
  • 50.07 (n)
  • 45.29 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes drs1 35
  • 56.19 (n)
  • 53.55 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6166 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9554 36
  • 76 (a)
OneToOne
Species with no ortholog for DARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DARS Gene

ENSEMBL:
Gene Tree for DARS (if available)
TreeFam:
Gene Tree for DARS (if available)

Paralogs for DARS Gene

Selected SIMAP similar genes for DARS Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with DARS: view

No data available for Paralogs for DARS Gene

Variants for DARS Gene

Sequence variations from dbSNP and Humsavar for DARS Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs14934 -- 135,906,907(-) AACTT(A/T)TTTTT utr-variant-3-prime
rs167442 -- 135,947,838(-) TTTTT(G/T)GTTTT intron-variant
rs177917 -- 135,928,823(-) CGTCT(C/T)TACTT intron-variant
rs192822 -- 135,924,704(-) GAAAT(A/T)CCTTT intron-variant
rs309112 -- 135,978,935(+) CACTC(G/T)TCACT intron-variant

Relevant External Links for DARS Gene

HapMap Linkage Disequilibrium report
DARS
Human Gene Mutation Database (HGMD)
DARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DARS Gene

Disorders for DARS Gene

(1) OMIM Diseases for DARS Gene (603084)

UniProtKB/Swiss-Prot

SYDC_HUMAN
  • Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL) [MIM:615281]: An autosomal recessive leukoencephalopathy characterized by onset in the first year of life of severe spasticity, mainly affecting the lower limbs and resulting in an inability to achieve independent ambulation. Affected individuals show delayed motor development and nystagmus; some may have mild mental retardation. Brain MRI shows hypomyelination and white matter lesions in the cerebrum, brainstem, cerebellum, and spinal cord. {ECO:0000269 PubMed:23643384}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DARS

Genetic Association Database (GAD)
DARS
genes like me logo Genes that share disorders with DARS: view

Publications for DARS Gene

  1. Lysyl-tRNA synthetase interacts with EF1alpha, aspartyl-tRNA synthetase and p38 in vitro. (PMID: 18029264) Guzzo C.M. … Yang D.C.H. (Biochem. Biophys. Res. Commun. 2008) 3 4 23
  2. cDNA sequence, predicted primary structure, and evolving amphiphilic helix of human aspartyl-tRNA synthetase. (PMID: 2674137) Jacobo-Molina A. … Yang D.C.H. (J. Biol. Chem. 1989) 2 3 4
  3. Genetic dissection of protein-protein interactions in multi-tRNA synthetase complex. (PMID: 10200289) Rho S.B. … Shiba K. (Proc. Natl. Acad. Sci. U.S.A. 1999) 3 23
  4. Structure of the N-terminal extension of human aspartyl-tRNA synthetase: implications for its biological function. (PMID: 12824064) Cheong H.K. … Cheong C. (Int. J. Biochem. Cell Biol. 2003) 3 23
  5. Expression of human aspartyl-tRNA synthetase in Escherichia coli. Functional analysis of the N-terminal putative amphiphilic helix. (PMID: 8449960) Escalante C. … Yang D.C. (J. Biol. Chem. 1993) 3 23

Products for DARS Gene

Sources for DARS Gene

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