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Aliases for DARS Gene

Aliases for DARS Gene

  • Aspartyl-TRNA Synthetase 2 3 4 5
  • Cell Proliferation-Inducing Gene 40 Protein 3 4
  • EC 6.1.1.12 4 63
  • AspRS 3 4
  • Aspartyl-TRNA Synthetase, Cytoplasmic 3
  • Aspartate TRNA Ligase 1, Cytoplasmic 3
  • Testicular Tissue Protein Li 192 3
  • Aspartate TRNA Ligase 1 2
  • Cytoplasmic 2
  • HBSL 3

External Ids for DARS Gene

Previous GeneCards Identifiers for DARS Gene

  • GC02M134319
  • GC02M134961
  • GC02M136686
  • GC02M136875
  • GC02M136497
  • GC02M136380
  • GC02M128656

Summaries for DARS Gene

Entrez Gene Summary for DARS Gene

  • This gene encodes a member of a multienzyme complex that functions in mediating the attachment of amino acids to their cognate tRNAs. The encoded protein ligates L-aspartate to tRNA(Asp). Mutations in this gene have been found in patients showing hypomyelination with brainstem and spinal cord involvement and leg spasticity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]

GeneCards Summary for DARS Gene

DARS (Aspartyl-TRNA Synthetase) is a Protein Coding gene. Diseases associated with DARS include hypomyelination with brainstem and spinal cord involvement and leg spasticity and spasticity. Among its related pathways are Gene Expression and Metabolism. GO annotations related to this gene include nucleic acid binding and nucleotide binding.

UniProtKB/Swiss-Prot for DARS Gene

  • Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

Gene Wiki entry for DARS Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DARS Gene

Genomics for DARS Gene

Regulatory Elements for DARS Gene

Promoters for DARS Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DARS on UCSC Golden Path with GeneCards custom track

Genomic Location for DARS Gene

Chromosome:
2
Start:
135,905,881 bp from pter
End:
135,986,100 bp from pter
Size:
80,220 bases
Orientation:
Minus strand

Genomic View for DARS Gene

Genes around DARS on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DARS Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DARS Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DARS Gene

Proteins for DARS Gene

  • Protein details for DARS Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14868-SYDC_HUMAN
    Recommended name:
    Aspartate--tRNA ligase, cytoplasmic
    Protein Accession:
    P14868
    Secondary Accessions:
    • A8K3J2
    • D3DP77
    • Q2TNI3
    • Q32Q69
    • Q53HV4
    • Q53YC5
    • Q68CR9
    • Q9BW52

    Protein attributes for DARS Gene

    Size:
    501 amino acids
    Molecular mass:
    57136 Da
    Quaternary structure:
    • Homodimer; also part of a multisubunit complex that groups AIMP1, AIMP2, EEF1A1 and tRNA ligases for Arg, Asp, Glu, Gln, Ile, Leu, Lys, Met and Pro.

    Three dimensional structures from OCA and Proteopedia for DARS Gene

    Alternative splice isoforms for DARS Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DARS Gene

Proteomics data for DARS Gene at MOPED

Post-translational modifications for DARS Gene

  • Ubiquitination at Lys 330
  • Modification sites at PhosphoSitePlus

Other Protein References for DARS Gene

Antibody Products

Domains & Families for DARS Gene

Gene Families for DARS Gene

Suggested Antigen Peptide Sequences for DARS Gene

Graphical View of Domain Structure for InterPro Entry

P14868

UniProtKB/Swiss-Prot:

SYDC_HUMAN :
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
Family:
  • Belongs to the class-II aminoacyl-tRNA synthetase family.
genes like me logo Genes that share domains with DARS: view

Function for DARS Gene

Molecular function for DARS Gene

UniProtKB/Swiss-Prot CatalyticActivity:
ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp).
UniProtKB/Swiss-Prot Function:
Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA.

Enzyme Numbers (IUBMB) for DARS Gene

Gene Ontology (GO) - Molecular Function for DARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004046 aminoacylase activity TAS 8449960
GO:0004815 aspartate-tRNA ligase activity IEA --
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DARS: view
genes like me logo Genes that share phenotypes with DARS: view

Human Phenotype Ontology for DARS Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for DARS Gene

Localization for DARS Gene

Subcellular locations from UniProtKB/Swiss-Prot for DARS Gene

Cytoplasm.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DARS Gene COMPARTMENTS Subcellular localization image for DARS gene
Compartment Confidence
cytosol 5
extracellular 5
nucleus 2

Gene Ontology (GO) - Cellular Components for DARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
genes like me logo Genes that share ontologies with DARS: view

Pathways & Interactions for DARS Gene

genes like me logo Genes that share pathways with DARS: view

Pathways by source for DARS Gene

Gene Ontology (GO) - Biological Process for DARS Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006422 aspartyl-tRNA aminoacylation IEA --
GO:0006461 protein complex assembly TAS 8449960
genes like me logo Genes that share ontologies with DARS: view

No data available for SIGNOR curated interactions for DARS Gene

Drugs & Compounds for DARS Gene

(9) Drugs for DARS Gene - From: Novoseek, HMDB, and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Aspartic acid Approved Nutra Target NMDA agonist 0
Adenosine monophosphate Approved Nutra 0
Adenosine triphosphate Approved Nutra 0
Diphosphate Experimental Pharma 0
Ureidosuccinic acid Experimental Pharma 0

(7) Additional Compounds for DARS Gene - From: Novoseek and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
phosphoric acid
  • Acide phosphorique (FRENCH)
  • Acido fosforico [Italian]
  • Acidum phosphoricum
  • Diphosphate tetrasodium
  • Fosforzuuroplossingen [Dutch]
7664-38-2
genes like me logo Genes that share compounds with DARS: view

Transcripts for DARS Gene

Unigene Clusters for DARS Gene

Aspartyl-tRNA synthetase:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DARS Gene

No ASD Table

Relevant External Links for DARS Gene

GeneLoc Exon Structure for
DARS
ECgene alternative splicing isoforms for
DARS

Expression for DARS Gene

mRNA expression in normal human tissues for DARS Gene

Protein differential expression in normal tissues from HIPED for DARS Gene

This gene is overexpressed in Lymph node (8.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DARS Gene



SOURCE GeneReport for Unigene cluster for DARS Gene Hs.503787

mRNA Expression by UniProt/SwissProt for DARS Gene

P14868-SYDC_HUMAN
Tissue specificity: Expression in the developing and adult brain shows similar patterns. Highly expressed in the ventricular and subventricular zones, including hippocampal subfields, the midlateral temporaal cortex and the frontal polar cortex. The cerebellum, cereral cortex, hippocampus, and lateral ventricle show preferential neuronal expression. Expression in the peripheral neurons is evident in the colon.
genes like me logo Genes that share expression patterns with DARS: view

Protein tissue co-expression partners for DARS Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DARS Gene

Orthologs for DARS Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DARS Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DARS 35
  • 93.21 (n)
  • 96.01 (a)
DARS 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DARS 35
  • 93.88 (n)
  • 97.41 (a)
DARS 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dars 35
  • 91.75 (n)
  • 96.01 (a)
Dars 16
Dars 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DARS 35
  • 99.73 (n)
  • 99.6 (a)
DARS 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dars 35
  • 90.95 (n)
  • 95.61 (a)
oppossum
(Monodelphis domestica)
Mammalia DARS 36
  • 95 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DARS 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves DARS 35
  • 82.17 (n)
  • 89.82 (a)
DARS 36
  • 89 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DARS 36
  • 85 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dars 35
  • 77.71 (n)
  • 91.04 (a)
MGC76305 35
African clawed frog
(Xenopus laevis)
Amphibia dars-prov 35
zebrafish
(Danio rerio)
Actinopterygii dars 35
  • 76.6 (n)
  • 85.63 (a)
wufc17a11 35
dars 36
  • 78 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Aats-asp 37
  • 68 (a)
Aats-asp 35
  • 62.92 (n)
  • 67.67 (a)
Aats-asp 36
  • 63 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005576 35
  • 60.13 (n)
  • 68.68 (a)
worm
(Caenorhabditis elegans)
Secernentea drs-1 37
  • 63 (a)
dars-1 35
  • 62.57 (n)
  • 64.58 (a)
dars-1 36
  • 60 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_ADL039C 35
  • 55.47 (n)
  • 55.53 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0D03839g 35
  • 58.18 (n)
  • 57.64 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes DPS1 35
  • 57.74 (n)
  • 57.81 (a)
DPS1 36
  • 52 (a)
OneToOne
DPS1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT4G31180 35
  • 55.85 (n)
  • 52.98 (a)
soybean
(Glycine max)
eudicotyledons Gma.1067 35
Alicante grape
(Vitis vinifera)
eudicotyledons Vvi.10065 35
barley
(Hordeum vulgare)
Liliopsida Hv.2597 35
rice
(Oryza sativa)
Liliopsida Os.12716 35
Os02g0686400 35
  • 55.71 (n)
  • 53.96 (a)
wheat
(Triticum aestivum)
Liliopsida Ta.14416 35
corn
(Zea mays)
Liliopsida Zm.3547 35
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6166 35
bread mold
(Neurospora crassa)
Ascomycetes NCU07082 35
  • 50.07 (n)
  • 45.29 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes drs1 35
  • 56.19 (n)
  • 53.55 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9554 36
  • 76 (a)
OneToOne
Species with no ortholog for DARS:
  • Actinobacteria (Mycobacterium tuberculosis)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)

Evolution for DARS Gene

ENSEMBL:
Gene Tree for DARS (if available)
TreeFam:
Gene Tree for DARS (if available)

Paralogs for DARS Gene

genes like me logo Genes that share paralogs with DARS: view

No data available for Paralogs for DARS Gene

Variants for DARS Gene

Sequence variations from dbSNP and Humsavar for DARS Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1803165 - 135,911,446(-) ATATT(G/T)TCAGG reference, missense
VAR_070038 Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)
VAR_070039 Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)
VAR_070040 Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)
VAR_070041 Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL)

Variation tolerance for DARS Gene

Residual Variation Intolerance Score: 28.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.16; 39.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DARS Gene

HapMap Linkage Disequilibrium report
DARS
Human Gene Mutation Database (HGMD)
DARS

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DARS Gene

Disorders for DARS Gene

MalaCards: The human disease database

(2) MalaCards diseases for DARS Gene - From: OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, and GeneCards

Disorder Aliases PubMed IDs
hypomyelination with brainstem and spinal cord involvement and leg spasticity
  • hypomyelination with brain stem and spinal cord involvement and leg spasticity
spasticity
- elite association - COSMIC cancer census association via MalaCards
Search DARS in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

SYDC_HUMAN
  • Hypomyelination with brainstem and spinal cord involvement and leg spasticity (HBSL) [MIM:615281]: An autosomal recessive leukoencephalopathy characterized by onset in the first year of life of severe spasticity, mainly affecting the lower limbs and resulting in an inability to achieve independent ambulation. Affected individuals show delayed motor development and nystagmus; some may have mild mental retardation. Brain MRI shows hypomyelination and white matter lesions in the cerebrum, brainstem, cerebellum, and spinal cord. {ECO:0000269 PubMed:23643384}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for DARS

Genetic Association Database (GAD)
DARS
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DARS
genes like me logo Genes that share disorders with DARS: view

No data available for Genatlas for DARS Gene

Publications for DARS Gene

  1. cDNA sequence, predicted primary structure, and evolving amphiphilic helix of human aspartyl-tRNA synthetase. (PMID: 2674137) Jacobo-Molina A. … Yang D.C.H. (J. Biol. Chem. 1989) 2 3 4 67
  2. Loss of a primordial identity element for a mammalian mitochondrial aminoacylation system. (PMID: 16597625) Fender A. … Sissler M. (J. Biol. Chem. 2006) 23 25 26
  3. Lysyl-tRNA synthetase interacts with EF1alpha, aspartyl-tRNA synthetase and p38 in vitro. (PMID: 18029264) Guzzo C.M. … Yang D.C.H. (Biochem. Biophys. Res. Commun. 2008) 3 23
  4. Drugs, their targets and the nature and number of drug targets. (PMID: 17016423) Imming P. … Meyer A. (Nat Rev Drug Discov 2006) 25 26
  5. How many drug targets are there? (PMID: 17139284) Overington J.P. … Hopkins A.L. (Nat Rev Drug Discov 2006) 25 26

Products for DARS Gene

Sources for DARS Gene

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