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DARC Gene

protein-coding GIFtS: 54

GC01P157440

Duffy blood group, chemokine receptor
(Previous name: Duffy blood group )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: FY)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CCBP1 ^¹, ²
CD234 ^¹, ²
Dfy ^¹, ²
FY ^², ³
GPD ^¹, ², ³
GpFy ^², ³
OTTHUMP00000035293 ^²
OTTHUMP00000060081 ^²
WBCQ1 ^²

Descriptions
CD234 antigen ^³
Duffy blood group ^¹
Duffy blood group antigen ^²
Duffy blood group, chemokine receptor ^²
Fy glycoprotein ^², ³
Glycoprotein D ^², ³
Plasmodium vivax receptor ^³

External Ids
HGNC: 4035¹
Entrez Gene: 2532²
UniProtKB: Q16570³
Ensembl: ENSG00000213088⁷

Search outside databases for aliases for DARC gene

Previous GC identifer: GC01P157409

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DARC:

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for

several chemokines. The encoded protein is the receptor for the human malarial parasites

Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy

blood group system. Two transcript variants encoding different isoforms have been found for this

gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570

Function: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It

is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi

Gene Wiki entry for DARC

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DARC gene

Entrez Gene cytogenetic band: 1q21-q22 Ensembl cytogenetic band: 1q23.2 HGNC cytogenetic band: 1q21-q22

DARC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 1 GeneLoc Exon Structure

GeneLoc location for GC01P157440: (about GC identifiers)

Start:	157,439,721 bp from pter
End:	157,442,914 bp from pter
Size:	3,194 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000001.9 NT_004487.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570 (See protein sequence)

Recommended Name: Duffy antigen/chemokine receptor

Size: 336 amino acids; 35553 Da

Subcellular location: Membrane; Multi-pass membrane protein

Secondary accessions: A8YPG5 O75898 Q16300 Q8WWE3 Q9UJP0 Q9UKZ5 Q9UKZ6 Q9UQE1

Alternative splicing: 2 isoforms: Q16570-1 Q16570-2

REFSEQ proteins (2 alternative transcripts):

NP_001116423.1 NP_002027.2

ENSEMBL proteins:

ENSP00000352341 ENSP00000357104 ENSP00000357103

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DARC)
	Human Recombinant Proteins from Abnova (FY)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	7689250
GO:0016021	integral to membrane	IEA	--

About this table

Antibodies for DARC:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for DARC
	R&D Systems Antibodies for DARC
	Antibodies from Abcam (DARC), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (FY)
	Novus Biologicals Antibodies for DARC

Assays for DARC:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry Q16570

ProtoNet protein and cluster: Q16570

1 Blocks protein family: IPB005384 Duffy antigen/chemokine receptor signature

UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570

Similarity: Belongs to the G-protein coupled receptor Duffy family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DARC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FY)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001122951

Applied Biosystems Silencer® siRNAs for DARC

Sigma-Aldrich siRNA for DARC

Sigma-Aldrich shRNA Panels and shRNA for DARC

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DARC
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001122951
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001122951
untagged cDNA clones in CMV expression vector (see all 3): NM_001122951

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001122951

UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570

Function: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It

is also the receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi

Genatlas biochemistry entry for DARC:

Duffy antigen,receptor for chemokines and plasmodium vivax

3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Darc):

homeostasis/metabolism

immune system

skeleton

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004930	G-protein coupled receptor activity	IEA	--
GO:0004950	chemokine receptor activity	NAS	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for DARC

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006952	defense response	NAS	10570183
GO:0007165	signal transduction	IEA	--
GO:0007186	G-protein coupled receptor protein signaling pathway	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DARC
7 Novoseek chemical compound relationships for DARC gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
rantes	48.72	6	15572394 (2), 9195930 (1), 10925048 (1), 15720550 (1) (see all 5)
monophosphoryl lipid a	43.88	1	14711338 (1)
mannose 6-phosphate	35.68	7	12021353 (1), 9525660 (1), 7745699 (1)
glyceraldehyde 3-phosphate	5.77	2	1367405 (1), 16153028 (1)
phenylalanine	0.00	3	15720550 (3)
lipid	0.00	1	17299053 (1)
tyrosine	0.00	1	7511603 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DARC)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (FY)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001122951

Sigma-Aldrich siRNA for DARC

Sigma-Aldrich shRNA Panels and shRNA for DARC

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001122951 NM_002036

REFSEQ mRNAs for DARC gene (2 alternative transcripts):

NM_001122951.1 NM_002036.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001122951 NM_002036

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_001122951
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_001122951
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001122951

Additional cDNA sequence:

AF030521.1 AK291593.1 AK309521.1 AY167991.1 BC017817.1 BC095496.1 BX537430.1 U01839.1

5 DOTS entries:

DT.421927 DT.100773431 DT.121396982 DT.92419466 DT.95130101

24/264 AceView cDNA sequences (see all 264 ):

AI955148 AW294540 AW296169 CR605082 NM_002036 BU150151 BQ898419 N47613

BQ640233 BM671230 AI366692 BM972973 AY046418 AI564838 BM998664 BX281058

AI094929 BM697018 AI318397 AU150243 CB154618 T30476 CD676370 CD673597

highest scoring ESTs for DARC:

AA284947 AA285100 AA480120 AA482092 AA724903 AA855034 AA916897 AF030521 AI031548 AI092154

Unigene Cluster for DARC:

Duffy blood group, chemokine receptor

Hs.153381 [show with all ESTs]

Unigene Representative Sequence: AK291593

GeneLoc Exon Structure

3 Ensembl transcripts including schematic representations:

ENST00000359381 ENST00000368122 ENST00000368121

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DARC expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DARC

¹ / ² / ³

3 probe-sets matching DARC gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
33295_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	X85785	0.20	1.00	0.72	1
208335_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_002036	0.60	0.83	0.73	1
208335_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks DARC for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TCTGGCCCAG

SOURCE GeneReport for Unigene cluster: Hs.153381
UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570
Tissue specificity: Found in adult kidney, adult spleen, bone marrow and fetal liver. In
particular, it is expressed along postcapillary venules throughout the body, except in the adult
liver. Erythroid cells and postcapillary venule endothelium are the principle tissues expressing
duffy. Fy(-A-B) individuals do not express duffy in the bone marrow, however they do, in
postcapillary venule endothelium

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DARC gene from 4 species

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DARC¹	--	Duffy blood group, chemokine receptor	74.14(n) 65.15(a)	478969 XM_536127.2 XP_536127.2
chimpanzee (Pan troglodytes)	DARC¹	--	Duffy blood group, chemokine receptor	99.4(n) 99.11(a)	745985 XM_001170565.1 XP_001170565.1
cow (Bos taurus)	DARC¹	--	Duffy blood group, chemokine receptor	74.95(n) 64.24(a)	528076 NM_001015634.1 NP_001015634.1
mouse (Mus musculus)	Darc^{1, 5}	1 (94.00 cM)⁵	Duffy blood group, chemokine receptor^{1, 5}	71.07(n)¹ 60.36(a)¹	13349¹ NM_010045.2¹ NP_034175.2¹ AA162249⁵ AB039074⁵ (see all 21)

About this table Species with no ortholog for DARC

ENSEMBL Gene Tree for DARC

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570

Polymorphism: DARC is responsible for the Duffy blood group system. The molecular basis of the

Fy(A)=Fy1/Fy(B)=Fy2 blood group antigens is a single variation in position 42; Gly-42 corresponds

to Fy(A) and Asp-42 to Fy(B)

Polymorphism: Genetic variation in DARC is associated with white blood cell count quantitative

trait locus type 1 (WBCQ1) [MIM:611862]. Peripheral white blood cell count (WBC) is a common

clinical measurement, used to determine evidence of acute infammation or infection. Peripheral WBC

is the sum of several cell types including neutrophils and lymphocytes, which are the most common

types of WBC, as well as less common cell types such as eosinophils, basophils, and monocytes.

Elevated WBC has been associated with risk of coronary heart disease, cancer, and all-cause

mortality. White blood cell levels have widespread clinical applications including assessment of

patients undergoing chemotherapy and evaluation of infection

10/259 NCBI SNPs in DARC are shown (see all 259 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 125)

AB	SNP ID	Valid	Chr 1 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs13962^1,2	A,C,F,H	157442151(+)	`TCCTGG/ACACAG`	2	T/A	mis¹		7	MN EU EA WA NA	666
	rs3027012^1,2	A,C,F,H	157440747(+)	`GCAAAC/TGTACA`	1	--	ng5¹		9	MN EU EA WA	860
	rs12075^1,2	A,C,F,H	157441978(+)	`CTATGG/ATGCCA`	2	D/G	mis¹		16	MN EU EA WA NA	1692
	rs3027009^1,2	C,F,H	157440511(+)	`AGCCTG/ACTTTA`	1	--	ng5¹		4	EU EA WA	420
	rs2814778^1,2	A,C,F	157441307(-)	`CCAAGA/GTAAGA`	1	--	ut5¹		12	CSA EU CSAM NA MN	876
--	rs6676002^1,2	C,F	157439768(+)	`CTTTCC/TAGAGA`	1	--	ng5¹		1	MN	22
--	rs12042349^1,2	C,F	157443114(+)	`GGAACC/TAGAGC`	1	--	ng3¹		1	MN	22
	rs3027008^1,2	C,F	157440163(+)	`GCTCAC/TCGCTC`	1	--	ng5¹		1	MN	22
	rs3027018^1,2	H	157442097(+)	`TCTTCA/CTGCTT`	2	M/L	mis¹		4	EU EA WA	406
--	rs36003596^1,2	F	157440152(+)	`GACACG/ACCATG`	1	--	ng5¹		1	MN	22

About this table

HapMap Linkage Disequilibrium images for DARC (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 110700

UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570

Individuals that do not produce the Duffy antigen (FY(A-B-)) are more resistant to vivax

malaria. This allele is found predominantly in population of African origin

10/21 Novoseek disease relationships for DARC gene (see all 21 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
herpes simplex	83.92	72	8388365 (2), 12021353 (2), 7911177 (2), 12885915 (2) (see all 66)
pseudorabies	68.28	2	11162814 (1), 15534229 (1)
genital herpes	64.02	3	7911177 (2), 8158042 (1)
herpes	53.58	6	11162814 (1), 18468509 (1), 18358807 (1), 17390046 (1) (see all 5)
viral shedding	49.00	1	8158042 (1)
hemolytic disease	37.95	1	9531948 (1)
drug addiction	37.94	7	11019561 (2), 17037343 (1), 15675365 (1), 16734277 (1)
malaria	34.76	6	18621004 (1), 10712211 (1), 15720550 (1), 10960522 (1) (see all 5)
drug dependence	33.07	5	17037343 (3), 11019561 (1), 15160890 (1)
virus infection	29.84	3	8388365 (1), 2164044 (1), 12885915 (1)

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Blood Group Antigen Gene Mutation Database (BGMUT) Duffy blood group system

Human Gene Mutation Database: DARC
Human Genome Epidemiology Navigator: DARC (21 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/209 PubMed articles for DARC gene (see all 209 ):

Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. (PubMed id 8248172)^{1, 2, 3, 4} Chaudhuri A....Pogo A. (1993)
Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals. (PubMed id 7663520)^{2, 3, 4} Tournamille C....Le Van Kim C. (1995)
Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue. (PubMed id 7833467)^{1, 3, 4} Iwamoto S.... Ikemoto S. (1995)
Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals. (PubMed id 9731074)^{1, 3, 4} Tournamille C.... Colin Y. (1998)
Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites. (PubMed id 12956774)^{1, 3, 4} Tournamille C.... Le Van Kim C. (2003)
Molecular basis and PCR-DNA typing of the Fya/fyb blood group polymorphism. (PubMed id 7705836)^{1, 3, 4} Tournamille C.... Colin Y. (1995)
The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)^{3, 4} Gregory S.G.... Bentley D.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea. (PubMed id 10570183)^{3, 4} Zimmerman P.A....Kazura J.W. (1999)
The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein. (PubMed id 9886340)^{3, 4} Olsson M.L.... Daniels G. (1998)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 2532	HGNC: 4035	AceView: FYandIGSF4B	Ensembl:ENSG00000213088	euGenes: HUgn2532
ECgene: DARC	H-InvDB: DARC

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
dbRBC/BGMUT	http://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=duffy
GeneReviews	http://www.genetests.org/query?gene=DARC
Wikipedia	http://en.wikipedia.org/wiki/Duffy_antigen

Licensable Technologies for DARC
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for DARC:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DARC-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DARC		Antibodies for DARC
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DARC		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

	Recombinant Proteins (FY)
	Antibodies (FY)
	Chimera RNAi (FY)
	Custom Service for Mouse Mab
	Custom Service for Rabbit Pab from Full-length Protein

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DARC Gene

protein-coding GIFtS: 54

Aliases &
Descriptions
for DARC

Summaries
for DARC

Genomic Location
for DARC

Proteins
for DARC

Protein Domains/
Families
for DARC

Gene Function
for DARC

Pathways & Interactions
for DARC

Drugs & Compounds
for DARC

Transcripts
for DARC

Expression
for DARC

Orthologs
for DARC

Paralogs
for DARC

SNPs/Variants
for DARC

Disorders & Mutations
for DARC

Medical News
for DARC

Publications
for DARC

Search for DARC

Genome Databases showing DARC

Other Databases showing DARC

Specialized Databases showing DARC

Licensable Technologies
for DARC

Services
for DARC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DARC Gene

protein-coding GIFtS: 54

Aliases & Descriptionsfor DARC

Summariesfor DARC

Genomic Locationfor DARC

Proteinsfor DARC

Protein Domains/Familiesfor DARC

Gene Functionfor DARC

Pathways & Interactionsfor DARC

Drugs & Compoundsfor DARC

Transcriptsfor DARC

Expression for DARC

Orthologsfor DARC

Paralogsfor DARC

SNPs/Variantsfor DARC

Disorders & Mutationsfor DARC

Medical Newsfor DARC

Publicationsfor DARC

Search for DARC

Genome Databases showing DARC

Other Databases showing DARC

Specialized Databases showing DARC

Licensable Technologiesfor DARC

Servicesfor DARC

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DARC

Summaries
for DARC

Genomic Location
for DARC

Proteins
for DARC

Protein Domains/
Families
for DARC

Gene Function
for DARC

Pathways & Interactions
for DARC

Drugs & Compounds
for DARC

Transcripts
for DARC

Expression
for DARC

Orthologs
for DARC

Paralogs
for DARC

SNPs/Variants
for DARC

Disorders & Mutations
for DARC

Medical News
for DARC

Publications
for DARC

Licensable Technologies
for DARC

Services
for DARC