Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DARC Gene

protein-coding   GIFtS: 62
GCID: GC01P159173

Duffy Blood Group, Atypical Chemokine Receptor

(Previous names: Duffy blood group, Duffy blood group, chemokine receptor)
(Previous symbol: FY)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Duffy Blood Group, Atypical Chemokine Receptor1 2     Fy Glycoprotein2 3
FY1 2 3 5     WBCQ12 5
Atypical Chemokine Receptor 11 2 3     Duffy Blood Group1
GPD2 3 5     CCBP12
Duffy Blood Group, Chemokine Receptor1 2     CD2342
Glycoprotein D2 3     Dfy2
Plasmodium Vivax Receptor2 3     Duffy Antigen/Chemokine Receptor2
ACKR12 3     Duffy Blood Group Antigen2
GpFy2 3     CD234 Antigen3

External Ids:    HGNC: 40351   Entrez Gene: 25322   Ensembl: ENSG000002130887   OMIM: 6136655   UniProtKB: Q165703   

Export aliases for DARC gene to outside databases

Previous GC identifers: GC01P157409 GC01P157440 GC01P130531


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DARC Gene:
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several
chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium
knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DARC Gene:
DARC (Duffy blood group, atypical chemokine receptor) is a protein-coding gene. Diseases associated with DARC include genital herpes, and malaria, vivax, protection against. GO annotations related to this gene include receptor activity and chemokine receptor activity.

UniProtKB/Swiss-Prot: ACKR1_HUMAN, Q16570
Function: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine
binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine
sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or
chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile,
interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic
chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5,
CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May
regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when
expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines
and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood
reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine
levels

Gene Wiki entry for DARC (Duffy antigen system) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the DARC gene promoter:
         HEN1   MZF-1   LCR-F1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDARC promoter sequence
   Search Chromatin IP Primers for DARC

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DARC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q21-q22

DARC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DARC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P159173:  view genomic region     (about GC identifiers)

Start:
159,173,097 bp from pter      End:
159,176,290 bp from pter
Size:
3,194 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: ACKR1_HUMAN, Q16570 (See protein sequence)
Recommended Name: Duffy antigen/chemokine receptor  
Size: 336 amino acids; 35553 Da
Secondary accessions: A8YPG5 O75898 Q16300 Q8WWE3 Q9UJP0 Q9UKZ5 Q9UKZ6 Q9UQE1
Alternative splicing: 2 isoforms:  Q16570-1   Q16570-2   

Explore the universe of human proteins at neXtProt for DARC: NX_Q16570

Explore proteomics data for DARC at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn16, Asn33
  • Modification sites at PhosphoSitePlus

  • See DARC Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001116423.1  NP_002027.2  

    ENSEMBL proteins: 
     ENSP00000357104   ENSP00000398406   ENSP00000441985   ENSP00000357103  
    Reactome Protein details: Q16570

    DARC Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DARC
    OriGene Protein Over-expression Lysate for DARC
    OriGene MassSpec for DARC
    OriGene Custom Protein Services for DARC
    GenScript Custom Purified and Recombinant Proteins Services for DARC
    Novus Biologicals DARC Proteins
    Novus Biologicals DARC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DARC

    DARC Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DARC
    R&D Systems Antibodies for DARC
    OriGene Antibodies for DARC
    OriGene Custom Antibody Services for DARC
    Novus Biologicals DARC Antibodies
    Abcam antibodies for DARC
    Cloud-Clone Corp. Antibodies for DARC
    ThermoFisher Antibodies for DARC
    LSBio Antibodies in human, mouse, rat for DARC

    DARC Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DARC
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DARC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DARC
    Cloud-Clone Corp. CLIAs for DARC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    IUPHAR Guide to PHARMACOLOGY protein family classification: DARC
    Chemokine receptors

    1 InterPro protein domain:
     IPR005384 Duffy_chemokine_rcpt

    Graphical View of Domain Structure for InterPro Entry Q16570

    ProtoNet protein and cluster: Q16570

    1 Blocks protein domain: IPB005384 Duffy antigen/chemokine receptor signature

    UniProtKB/Swiss-Prot: ACKR1_HUMAN, Q16570
    Similarity: Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily


    DARC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: ACKR1_HUMAN, Q16570
    Function: Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine
    binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine
    sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or
    chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile,
    interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic
    chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5,
    CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P.vivax and P.knowlesi. May
    regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when
    expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines
    and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood
    reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine
    levels

         Genatlas biochemistry entry for DARC:
    Duffy antigen,receptor for chemokines and plasmodium vivax

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS7689250
    GO:0004888transmembrane signaling receptor activity TAS9058825
    GO:0004930G-protein coupled receptor activity IEA--
    GO:0004950chemokine receptor activity ----
    GO:0019956chemokine binding ----
         
    DARC for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Darc):
     homeostasis/metabolism  immune system  skeleton 

    DARC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DARC: Darctm1Scp Darctm1Pogo Darctm1Skmz

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DARC
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DARC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DARC
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DARC

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DARC using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DARC
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DARC
    Predesigned siRNA for gene silencing in human, mouse, rat DARC

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DARC

    Clone
    Products:
         
    OriGene clones in human, mouse for DARC (see all 12)
    OriGene ORF clones in mouse, rat for DARC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DARC (NM_001122951)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DARC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DARC

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DARC
    Browse ESI BIO Cell Lines and PureStem Progenitors for DARC 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DARC


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    ACKR1_HUMAN, Q16570: Early endosome. Recycling endosome. Membrane; Multi-pass membrane protein.
    Note=Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via
    caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the
    receptor is recycled back to the cell membrane
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane4
    cytoskeleton2
    extracellular2
    nucleus2
    cytosol1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005769early endosome IEA--
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--
    GO:0055037recycling endosome IEA--

    DARC for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DARC About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    3Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions
    Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions0.81
    4Neuropeptides signaling through G protein alpha i and G protein alpha q
    Peptide GPCRs0.46
    5Malaria
    Malaria

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DARC
        Chemokine Superfamily: Human/Mouse Ligand-Receptor Interactions


    2 BioSystems Pathways for DARC
        GPCRs, Other
    Peptide GPCRs

    1 Reactome Pathway for DARC
        Peptide ligand-binding receptors


    1 Kegg Pathway  (Kegg details for DARC):
        Malaria


    DARC for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DARC: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DARC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for DARC (Q165703 ENSP000003571034) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL2P135003, ENSP000002258314I2D: score=4 STRING: ENSP00000225831
    IL8P101453, ENSP000003065124I2D: score=3 STRING: ENSP00000306512
    CCL7P800983, ENSP000002003074I2D: score=2 STRING: ENSP00000200307
    CXCL1P093413, ENSP000003791104I2D: score=3 STRING: ENSP00000379110
    CCL5P135013, ENSP000002932724I2D: score=4 STRING: ENSP00000293272
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response NAS10570183
    GO:0006954inflammatory response IEA--
    GO:0032642regulation of chemokine production IEA--
    GO:0070098chemokine-mediated signaling pathway IEA--

    DARC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DARC (ACKR1)

    8 Novoseek inferred chemical compound relationships for DARC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monophosphoryl lipid a 52.4 4 14711338 (1), 19702506 (1)
    rantes 49.8 6 15572394 (2), 9195930 (1), 10925048 (1), 15720550 (1) (see all 5)
    mannose 6-phosphate 33.7 7 12021353 (1), 9525660 (1), 7745699 (1)
    glyceraldehyde 3-phosphate 3.17 2 1367405 (1), 16153028 (1)
    phenylalanine 0 3 15720550 (3)
    lipid 0 2 17299053 (1), 19786966 (1)
    tyrosine 0 1 7511603 (1)
    alanine 0 4 7744785 (2), 15720551 (1), 12956774 (1)



    DARC for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DARC gene (2 alternative transcripts): 
    NM_001122951.2  NM_002036.3  

    Unigene Cluster for DARC:

    Duffy blood group, chemokine receptor
    Hs.153381  [show with all ESTs]
    Unigene Representative Sequence: NM_002036
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368122 ENST00000435307 ENST00000537147 ENST00000368121(uc001ftp.4)

    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DARC using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate DARC
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DARC
    Predesigned siRNA for gene silencing in human, mouse, rat DARC
    Clone
    Products:
         
    OriGene clones in human, mouse for DARC (see all 12)
    OriGene ORF clones in mouse, rat for DARC
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DARC (NM_001122951)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DARC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DARC
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DARC
    OriGene qSTAR qPCR primer pairs in human, mouse for DARC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DARC
      QuantiTect SYBR Green Assays in human, mouse, rat DARC
      QuantiFast Probe-based Assays in human, mouse, rat DARC

    Additional mRNA sequence: 

    AF030521.1 AK291593.1 AK309521.1 AY167991.1 BC017817.1 BC095496.1 BX537430.1 HE572751.1 
    JX081310.1 U01839.1 

    6 DOTS entries:

    DT.421927  DT.100773431  DT.121396982  DT.92419466  DT.95130101  DT.95292525 

    Selected AceView cDNA sequences (see all 264):

    BU729842 AW294540 BU150151 CD673597 BM671230 BM998664 BU739599 T30476 
    BM697018 AW157521 AW170565 BE502006 BE467284 AI318397 AI955148 CD676370 
    CA425659 AI342121 BM704393 BU730550 AI366692 T08949 CB154618 BQ640233 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DARC expression in normal human tissues (normalized intensities)      DARC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGCCCAG
    DARC Expression
    About this image


    DARC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Proerythroblasts Hematopoietic Bone Marrow
     
     Neurons
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer
     
     Ovary (Reproductive System)
    DARC Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DARC Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.153381

    UniProtKB/Swiss-Prot: ACKR1_HUMAN, Q16570
    Tissue specificity: Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is
    expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and
    postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express
    duffy in the bone marrow, however they do, in postcapillary venule endothelium

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DARC: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DARC
    OriGene qSTAR qPCR primer pairs in human, mouse for DARC
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DARC
    QuantiTect SYBR Green Assays in human, mouse, rat DARC
    QuantiFast Probe-based Assays in human, mouse, rat DARC
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DARC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for DARC gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Darc1 , 5 Duffy blood group, chemokine receptor1, 5 71.07(n)1
    60.36(a)1
      1 (80.33 cM)5
    133491  NM_010045.21  NP_034175.21 
     1733318865 
    chicken
    (Gallus gallus)
    Aves DARC6
    Duffy blood group, atypical chemokine receptor
    29(a)
    1 ↔ 1
    25(1672509-1673429)


    ENSEMBL Gene Tree for DARC (if available)
    TreeFam Gene Tree for DARC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DARC gene
    2 SIMAP similar genes for DARC using alignment to 7 protein entries:     ACKR1_HUMAN (see all proteins):
    FY    DKFZp686D15198

    DARC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Polymorphic Variants from UniProtKB/Swiss-Prot
    ACKR1_HUMAN, Q16570: DARC is responsible for the Duffy blood group system (FY) [MIM:110700]. The molecular basis of the
    Fy(A)=Fy1/Fy(B)=Fy2 blood group antigens is a single variation in position 42; Gly-42 corresponds to Fy(A) and
    Asp-42 to Fy(B). Individuals that do not produce the Duffy antigen (FY(A-B-)) are more resistant to infection by
    the malarial parasite Plasmodium vivax. This allele is found predominantly in population of African origin
    [MIM:611162]
    ACKR1_HUMAN, Q16570: Genetic variations in DARC define the white blood cell count quantitative trait locus 1 (WBCQ1)
    [MIM:611862]. Peripheral white blood cell count (WBC) is a common clinical measurement, used to determine
    evidence of acute infammation or infection. Peripheral WBC is the sum of several cell types including neutrophils
    and lymphocytes, which are the most common types of WBC, as well as less common cell types such as eosinophils,
    basophils, and monocytes. Elevated WBC has been associated with risk of coronary heart disease, cancer, and
    all-cause mortality. White blood cell levels have widespread clinical applications including assessment of
    patients undergoing chemotherapy and evaluation of infection


    Selected SNPs for DARC (see all 361)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs120751,2,,4
    C,F,A,Hnon-pathogenic1165671735(+) CTATGA/GTGCCA 4 D G mis136Minor allele frequency- G:0.38MN NA NS EA WA CSA EU 8963
    rs345990821,2,,4
    C,Fpathogenic1165671875(-) CCAGCG/AGAAGA 4 /R /C mis15Minor allele frequency- A:0.01NA EU 5923
    rs413139081,2
    C,F--165668491(+) GAGTCC/TCCGGG 1 -- us2k14Minor allele frequency- T:0.09NA 126
    rs1818076631,2
    --165668609(+) CTATGC/TACCTC 1 -- us2k10--------
    rs354322891,2
    C,F--165668675(+) CATAGT/GCTGTA 1 -- us2k11Minor allele frequency- G:0.00MN 22
    rs1872763401,2
    --165668724(+) GATTTC/TCTGTC 1 -- us2k10--------
    rs1909283481,2
    --165668803(+) TGCCCC/TGCCTC 1 -- us2k10--------
    rs1495999571,2
    C--165668919(+) CACCCC/GCTTCA 1 -- us2k10--------
    rs609253111,2
    C,F--165668957(+) CAGCCG/ACTGGT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1400393731,2
    --165668993(+) CCCTCA/CCCTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DARC (159173097 - 159176290 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DARC: --
    Human Gene Mutation Database (HGMD): DARC
    Locus Specific Mutation Databases (LSDB): DARC

    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DARC
    DNA2.0 Custom Variant and Variant Library Synthesis for DARC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 613665   
    OMIM disorders: 110700  611162  611862  
    Selected diseases for DARC (see all 58):    About MalaCards
    genital herpes    malaria, vivax, protection against    plasmodium vivax malaria    neonatal herpes
    drug addiction    motor peripheral neuropathy    rhinotracheitis    meningoencephalitis
    drug dependence    crescentic glomerulonephritis    charcot-marie-tooth disease type 1    herpes simplex
    hereditary elliptocytosis    keratitis    malaria    food allergy
    hiv/aids    peripheral neuropathy    sickle cell anemia    patent ductus arteriosus

    7 diseases from the University of Copenhagen DISEASES database for DARC:
    Herpes simplex     Malaria     Keratitis     Rhinotracheitis
    Hereditary elliptocytosis     Vaccinia     Encephalitis

    DARC for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    Selected Novoseek inferred disease relationships for DARC gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 83.4 75 8388365 (2), 12021353 (2), 7911177 (2), 12885915 (2) (see all 69)
    pseudorabies 67 2 11162814 (1), 15534229 (1)
    genital herpes 64.9 4 7911177 (2), 19702506 (1), 8158042 (1)
    malaria vivax 59.2 3 20162434 (3)
    viral shedding 56.5 1 8158042 (1)
    herpes 54 9 11162814 (1), 18468509 (1), 18358807 (1), 17390046 (1) (see all 6)
    malaria 40.5 7 18621004 (1), 10712211 (1), 15720550 (1), 10960522 (1) (see all 6)
    hemolytic disease 35.4 1 9531948 (1)
    drug addiction 35.1 7 11019561 (2), 17037343 (1), 15675365 (1), 16734277 (1)
    drug dependence 30.6 5 17037343 (3), 11019561 (1), 15160890 (1)

    Genetic Association Database (GAD): DARC
    Human Genome Epidemiology (HuGE) Navigator: DARC (35 documents)

    Export disorders for DARC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DARC gene, integrated from 10 sources (see all 273):
    (articles sorted by number of sources associating them with DARC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. (PubMed id 8248172)1, 2, 3, 9 Chaudhuri A....Pogo A. (Proc. Natl. Acad. Sci. U.S.A. 1993)
    2. Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals. (PubMed id 7663520)1, 2, 3 Tournamille C.... Le van Kim C. (Nat. Genet. 1995)
    3. Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue. (PubMed id 7833467)1, 2, 9 Iwamoto S.... Ikemoto S. (Blood 1995)
    4. Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals. (PubMed id 9731074)1, 2, 9 Tournamille C.... Colin Y. (Blood 1998)
    5. FY polymorphisms and vivax malaria in inhabitants of Amazonas State, Brazil. (PubMed id 20162434)1, 4, 9 Albuquerque S.R....dos Santos M.C. (Parasitol. Res. 2010)
    6. Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean. (PubMed id 18710383)1, 4, 9 Grann V.R....Hershman D.L. (Br. J. Haematol. 2008)
    7. Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites. (PubMed id 12956774)1, 2, 9 Tournamille C.... Le Van Kim C. (Br. J. Haematol. 2003)
    8. The Duffy-null state is associated with a survival advantage in leukopenic HIV-infected persons of African ancestry. (PubMed id 19620399)1, 4, 9 Kulkarni H....Ahuja S.K. (Blood 2009)
    9. Genetic polymorphisms in TLR4, CR1 and Duffy genes are not associated with malaria resistance in patients from Baixo Amazonas region, Brazil. (PubMed id 19048480)1, 4, 9 Soares S.C....Silva W.A. (Genet. Mol. Res. 2008)
    10. Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease. (PubMed id 18248572)1, 4, 9 Afenyi-Annan A....Telen M.J. (Transfusion 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 2532 HGNC: 4035 AceView: FYandIGSF4B Ensembl:ENSG00000213088 euGenes: HUgn2532
    ECgene: DARC Kegg: 2532 H-InvDB: DARC

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DARC Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=duffy
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=DARC[genesymbol]
    Wikipedia http://en.wikipedia.org/wiki/Duffy_antigen

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DARC gene:
    Search GeneIP for patents involving DARC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of DARC
     Browse Purified and Recombinant Proteins at EMD Millipore
     
     EMD Millipore genomic analysis products

      
     Antibodies for DARC (DARC)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     cDNA Clones for DARC (DARC)   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DARC   OriGene RNAi products in human, mouse, rat for DARC  
     OriGene qPCR primer pairs and template standards for DARC   OriGene Protein Over-expression Lysate for DARC  
     OriGene MassSpec something-or-other for DARC   OriGene clones in human, mouse for DARC  
     OriGene qSTAR qPCR primer pairs in human, mouse for DARC   OriGene Purified Protein for DARC  
     OriGene ORF clones in mouse, rat for DARC   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DARC   OriGene Custom Protein Services for DARC  

     
     
     Block miRNA regulation of human, mouse, rat DARC using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DARC
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DARC Predesigned siRNA for gene silencing in human, mouse, rat DARC
     QuantiFast Probe-based Assays in human, mouse, rat DARC QuantiTect SYBR Green Assays in human, mouse, rat DARC
     PCR Arrays including human, mouse, rat DARC Search Chromatin IP Primers for DARC
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DARC  GeneGlobe Interaction Network for DARC
     Regulatory tfbs in DARC promoter
     GenScript Custom Purified and Recombinant Proteins Services for DARC GenScript cDNA clones with any tag delivered in your preferred vector for DARC
     GenScript Custom Assay Services for DARC GenScript Custom overexpressing Cell Line Services for DARC
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DARC (ACKR1)
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DARC antibodies
     DARC proteins
     DARC lysates
     Antibodies for DARC
     See all of Abcam's Antibodies, Kits and Proteins for DARC
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DARC
     Antibodies for DARC
     ELISAs for DARC
     CLIAs for DARC



     Browse ESI BIO Cell Lines and PureStem Progenitors for DARC
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DARC
     Browse SwitchGear 3'UTR luciferase reporter plasmids for DARC
     SwitchGear Promoter luciferase reporter plasmids for DARC
     ThermoFisher Antibodies for DARC
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DARC
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DARC
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DARC
     LSBio Antibodies in human, mouse, rat for DARC
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DARC gene at Home site.
    Version: 3.12.136 22 July 2014
    hostname: 356977-web1.xennexinc.com index build: 126 solr: 1.4