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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DARC Gene

protein-coding   GIFtS: 60
GCID: GC01P159173

Duffy blood group, chemokine receptor

(Previous name: Duffy blood group )
(Previous symbol: FY)
 Explore 62 diseases affiliated with
DARC via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DARC    

Aliases
for DARC gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Duffy Blood Group, Chemokine Receptor1 2     GpFy2 3
FY1 2 3 5     Fy Glycoprotein2 3
GPD1 2 3 5     WBCQ12 5
CCBP11 2     Duffy Blood Group1
CD2341 2     Duffy Antigen/Chemokine Receptor2
Dfy1 2     Duffy Blood Group Antigen2
Glycoprotein D2 3     CD234 Antigen3
Plasmodium Vivax Receptor2 3     

External Ids:    HGNC: 40351   Entrez Gene: 25322   Ensembl: ENSG000002130887   OMIM: 6136655   UniProtKB: Q165703   

Export aliases for DARC gene to outside databases

Previous GC identifers: GC01P157409 GC01P157440 GC01P130531


Summaries
for DARC gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DARC:
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines.
The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi.
Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570
Function: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor
for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi

Gene Wiki entry for DARC (Duffy antigen system)


Genomic Views
for DARC gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DARC gene promoter:
         HEN1   MZF-1   LCR-F1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DARC promoter sequence
   Search SABiosciences Chromatin IP Primers for DARC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DARC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q21-q22

DARC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DARC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P159173:  view genomic region     (about GC identifiers)

Start:
 159,173,097 bp from pter      End:
 159,176,290 bp from pter
Size:
 3,194 bases      Orientation:
 plus strand

Proteins
for DARC gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570 (See protein sequence)
Recommended Name: Duffy antigen/chemokine receptor  
Size: 336 amino acids; 35553 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A8YPG5 O75898 Q16300 Q8WWE3 Q9UJP0 Q9UKZ5 Q9UKZ6 Q9UQE1
Alternative splicing: 2 isoforms:  Q16570-1   Q16570-2   

Explore the universe of human proteins at neXtProt for DARC: NX_Q16570

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q16570

    • DARC Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001116423.1  NP_002027.2  

    ENSEMBL proteins: 
     ENSP00000357104   ENSP00000398406   ENSP00000441985   ENSP00000352341   ENSP00000357103  
    Reactome Protein details: Q16570
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    OriGene Purified Protein: DARC
    OriGene Protein Over-expression Lysate (see all 2): DARC
    OriGene Custom Protein Services for DARC 
    GenScript Custom Purified and Recombinant Proteins Services for DARC
    Novus Biologicals DARC Proteins
    Novus Biologicals DARC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DARC

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--


    DARC for ontologies           About GeneDecksing



    DARC Antibody Products: 
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    Uscn Antibodies for DARC
    ThermoFisher Antibodies for DARC

    Assay Products for DARC: 
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    Uscn ELISAs and CLIAs for DARC

    Protein Domains /
    Families
    for DARC gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DARC for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR005384 Duffy_chemokine_rcpt

    Graphical View of Domain Structure for InterPro Entry Q16570

    ProtoNet protein and cluster: Q16570

    1 Blocks protein family: IPB005384 Duffy antigen/chemokine receptor signature

    UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570
    Similarity: Belongs to the G-protein coupled receptor Duffy family


    Function
    for DARC gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570
    Function: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the receptor
    for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi

         Genatlas biochemistry entry for DARC:
    Duffy antigen,receptor for chemokines and plasmodium vivax

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DARC
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DARC (see all 4)
    OriGene shRNA RFP: DARC
    OriGene siRNA: DARC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DARC

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DARC

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DARC (see all 3)
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    GenScript: all cDNA clones in your preferred vector (see all 2): DARC (NM_001122951)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DARC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DARC 

    Cell Line
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    Search LifeMap BioReagents cell lines for DARC

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DARC

    Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS7689250
    GO:0004888transmembrane signaling receptor activity TAS9058825
    GO:0004950chemokine receptor activity NAS--
    GO:0019957C-C chemokine binding IPI7517217


    DARC for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-outs for DARC: Darctm1Scp Darctm1Pogo Darctm1Skmz
         3 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Darc):
     homeostasis/metabolism  immune system  skeleton 

    DARC for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DARC gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Class A/1 (Rhodopsin-like receptors)
    		Class A/1 (Rhodopsin-like receptors)1.00
    		Peptide ligand-binding receptors0.61
    		GPCR ligand binding0.75
    2Signaling by GPCR
    		Signaling by GPCR1.00
    		Signal Transduction0.56
    3GPCRs, Other
    		GPCRs, Other1.00
    4Malaria
    		Malaria1.00
    5Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    		Peptide GPCRs0.46

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    2 BioSystems Pathways for DARC 
        GPCRs, Other
    Peptide GPCRs

    5        Reactome Pathways for DARC
        Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)


    1         Kegg Pathway  (Kegg details for DARC):
        Malaria


    DARC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DARC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for DARC (Q165703 ENSP000003571034) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL2P135003, ENSP000002258314I2D: score=4 STRING: ENSP00000225831
    IL8P101453, ENSP000003065124I2D: score=3 STRING: ENSP00000306512
    CCL7P800983, ENSP000002003074I2D: score=2 STRING: ENSP00000200307
    CXCL1P093413, ENSP000003791104I2D: score=3 STRING: ENSP00000379110
    CCL5P135013, ENSP000002932724I2D: score=4 STRING: ENSP00000293272
    About this table

    Gene Ontology (GO): 5 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response NAS10570183
    GO:0006954inflammatory response IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0032642regulation of chemokine production IEA--
    GO:0070098chemokine-mediated signaling pathway NAS--


    DARC for ontologies           About GeneDecksing



    Drugs & Compounds
    for DARC gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DARC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DARC
    8 Novoseek chemical compound relationships for DARC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monophosphoryl lipid a 52.4 4 14711338 (1), 19702506 (1)
    rantes 49.8 6 15572394 (2), 9195930 (1), 10925048 (1), 15720550 (1) (see all 5)
    mannose 6-phosphate 33.7 7 12021353 (1), 9525660 (1), 7745699 (1)
    glyceraldehyde 3-phosphate 3.17 2 1367405 (1), 16153028 (1)
    phenylalanine 0 3 15720550 (3)
    lipid 0 2 17299053 (1), 19786966 (1)
    tyrosine 0 1 7511603 (1)
    alanine 0 4 7744785 (2), 15720551 (1), 12956774 (1)

    Search CenterWatch for drugs/clinical trials and news about DARC / DUFFY 

    Transcripts
    for DARC gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DARC gene (2 alternative transcripts): 
    NM_001122951.2  NM_002036.3  

    Unigene Cluster for DARC:

    Duffy blood group, chemokine receptor
    Hs.153381  [show with all ESTs]
    Unigene Representative Sequence: NM_002036
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368122 ENST00000435307 ENST00000537147 ENST00000359381(uc001fto.3)
    ENST00000368121(uc001ftp.4)

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): DARC
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DARC
    Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DARC
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DARC (see all 4)
    OriGene shRNA RFP: DARC
    OriGene siRNA: DARC
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DARC
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DARC (see all 3)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DARC (see all 3)
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    GenScript: all cDNA clones in your preferred vector (see all 2): DARC (NM_001122951)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DARC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DARC 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DARC
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DARC
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DARC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DARC

    Additional cDNA sequence: 

    AF030521.1 AK291593.1 AK309521.1 AY167991.1 BC017817.1 BC095496.1 BX537430.1 HE572751.1 
    JX081310.1 U01839.1 

    6 DOTS entries:

    DT.421927  DT.100773431  DT.121396982  DT.92419466  DT.95130101  DT.95292525 

    24/264 AceView cDNA sequences (see all 264):

    BM708111 NM_002036 BM708988 BM713575 AI094929 AI564838 BU683321 CR601573 
    CR605082 CB154618 AU150243 BU739599 BP346568 T08949 CD676370 AI318397 
    BM671230 BQ640233 BM704393 CD673597 BQ898419 BM722566 N47613 AW157521 

    GeneLoc Exon Structure


    Expression
    for DARC gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DARC expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TCTGGCCCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DARC expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EyeInner Nuclear LayerGABAergic Amacrine CellsAmacrine, Retina
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 1 LifeMap Cell 
    NameCategory
    Posterior foregut-like cells (A scalable, suspensi...)

    See DARC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DARC

    SOURCE GeneReport for Unigene cluster: Hs.153381

    UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570
    Tissue specificity: Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is expressed
    along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and postcapillary venule
    endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express duffy in the bone marrow,
    however they do, in postcapillary venule endothelium

        SABiosciences Expression via Pathway-Focused PCR Arrays including DARC: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

    Primer
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DARC
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DARC

    Orthologs
    for DARC gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for DARC gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Darc1 , 5 Duffy blood group, chemokine receptor1, 5 71.07(n)1
    60.36(a)1    		   1 (80.33 cM)5
    133491  NM_010045.21  NP_034175.21 
     1733318865 
    lizard
    (Anolis carolinensis)    		 Reptilia DARC6
    		 --
    		 31(a)
    		 1 ↔ 1
    		 GL343640.1(19354-20184)


    ENSEMBL Gene Tree for DARC (if available)
    TreeFam Gene Tree for DARC (if available) 

    Paralogs
    for DARC gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    		  --

    Genomic Variants
    for DARC gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570
    Polymorphism: DARC is responsible for the Duffy blood group system (FY) [MIM:110700]. The molecular basis of the
    Fy(A)=Fy1/Fy(B)=Fy2 blood group antigens is a single variation in position 42; Gly-42 corresponds to Fy(A) and Asp-42
    to Fy(B). Individuals that do not produce the Duffy antigen (FY(A-B-)) are more resistant to infection by the malarial
    parasite Plasmodium vivax. This allele is found predominantly in population of African origin [MIM:611162]
    Polymorphism: Genetic variations in DARC define the white blood cell count quantitative trait locus 1 (WBCQ1)
    [MIM:611862]. Peripheral white blood cell count (WBC) is a common clinical measurement, used to determine evidence of
    acute infammation or infection. Peripheral WBC is the sum of several cell types including neutrophils and lymphocytes,
    which are the most common types of WBC, as well as less common cell types such as eosinophils, basophils, and
    monocytes. Elevated WBC has been associated with risk of coronary heart disease, cancer, and all-cause mortality.
    White blood cell levels have widespread clinical applications including assessment of patients undergoing chemotherapy
    and evaluation of infection


    10/323 NCBI SNPs in DARC are shown (see all 323)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs120751,2
    		C,F,A,H,non-pathogenic159175354(+) CTATGA/GTGCCA 4 D G mis136Minor allele frequency- G:0.38MN NA NS EA WA CSA EU 8963
    rs345990821,2
    		C,F,pathogenic135000280(-) CCAGCG/AGAAGA 4 /R /C mis15Minor allele frequency- A:0.01NA EU 5923
    rs413139081,2
    		C,F,--130529249(+) GAGTCC/TCCGGG 1 -- us2k14Minor allele frequency- T:0.09NA 126
    rs354322891,2
    		C,--130529433(+) CATAGT/GCTGTA 1 -- us2k11Minor allele frequency- G:0.00MN 22
    rs609253111,2
    		C,--130529715(+) CAGCCG/ACTGGT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs341906921,2
    		C,--130529907(+) TTGTAC/TGGGGG 1 -- us2k11Minor allele frequency- T:0.04MN 22
    rs27460471,2
    		--130530489(+) CTCTAC/TGAGGT 2 -- us2k10--------
    rs360035961,2
    		F--130530667(+) GACACG/ACCATG 2 -- us2k11Minor allele frequency- A:0.09MN 22
    rs362050301,2
    		C,--130530908(+) AGATGC/TCTGGC 2 -- us2k10--------
    rs562723431,2
    		C,--130530941(+) TTATG-/CCCCCC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DARC (159173097 - 159176290 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DARC: --
    Human Gene Mutation Database (HGMD): DARC

    Locus Specific Mutation Databases (LSDB): DARC
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for DARC gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DARC for disorders           About GeneDecksing

    OMIM gene information: 613665   
    OMIM disorders: 110700  611162  611862  
    20/62 diseases for DARC (see all 62):    About MalaCards
    malaria, vivax, protection against    charcot-marie-tooth disease    white blood cell count qtl    charcot-marie-tooth disease type 1
    plasmodium vivax malaria    genital herpes    patent ductus arteriosus    hiv/aids
    herpetic keratitis    drug dependence    dengue hemorrhagic fever    drug addiction
    motor peripheral neuropathy    food allergy    hemorrhagic fever    hereditary elliptocytosis
    tooth disease    crescentic glomerulonephritis    peripheral neuropathy    herpes simplex

    7 diseases from the University of Copenhagen DISEASES database for DARC:
    Herpes simplex     Malaria     Keratitis     Hereditary elliptocytosis
    Vaccinia     Rhinotracheitis     Encephalitis

    10/24 Novoseek disease relationships for DARC gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 83.4 75 8388365 (2), 12021353 (2), 7911177 (2), 12885915 (2) (see all 69)
    pseudorabies 67 2 11162814 (1), 15534229 (1)
    genital herpes 64.9 4 7911177 (2), 19702506 (1), 8158042 (1)
    malaria vivax 59.2 3 20162434 (3)
    viral shedding 56.5 1 8158042 (1)
    herpes 54 9 11162814 (1), 18468509 (1), 18358807 (1), 17390046 (1) (see all 6)
    malaria 40.5 7 18621004 (1), 10712211 (1), 15720550 (1), 10960522 (1) (see all 6)
    hemolytic disease 35.4 1 9531948 (1)
    drug addiction 35.1 7 11019561 (2), 17037343 (1), 15675365 (1), 16734277 (1)
    drug dependence 30.6 5 17037343 (3), 11019561 (1), 15160890 (1)

    Human Genome Epidemiology (HuGE) Navigator: DARC (35 documents)

    Export disorders for DARC gene to outside databases

    Publications
    for DARC gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DARC gene, integrated from 9 sources (see all 259):
    (articles sorted by number of sources associating them with DARC)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. (PubMed id 8248172)1, 2, 3, 9 Chaudhuri A....Pogo A. (1993)
    2. Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals. (PubMed id 7663520)1, 2, 3 Tournamille C....Le Van Kim C. (1995)
    3. Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue. (PubMed id 7833467)1, 2, 9 Iwamoto S.... Ikemoto S. (1995)
    4. Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals. (PubMed id 9731074)1, 2, 9 Tournamille C.... Colin Y. (1998)
    5. Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites. (PubMed id 12956774)1, 2, 9 Tournamille C.... Le Van Kim C. (2003)
    6. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    8. Emergence of FY*A(null) in a Plasmodium vivax-endemic region of Papua New Guinea. (PubMed id 10570183)1, 2 Zimmerman P.A....Kazura J.W. (1999)
    9. The Fy(x) phenotype is associated with a missense mutation in the Fy(b) allele predicting Arg89Cys in the Duffy glycoprotein. (PubMed id 9886340)1, 2 Olsson M.L.... Daniels G. (1998)
    10. A novel mutation in the coding sequence of the FY*B allele of the Duffy chemokine receptor gene is associated with an altered erythrocyte phenotype. (PubMed id 9746760)1, 2 Parasol N.... Kosower N.S. (1998)

    External Searches for DARC gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DARC gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2532 HGNC: 4035 AceView: FYandIGSF4B Ensembl:ENSG00000213088 euGenes: HUgn2532
    ECgene: DARC Kegg: 2532 H-InvDB: DARC

    Other Databases showing DARC gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DARC gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DARC Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=duffy
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DARC
    Wikipedia http://en.wikipedia.org/wiki/Duffy_antigen

    Intellectual Property
    for DARC gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DARC gene:
    Search GeneIP for patents involving DARC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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