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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DARC Gene

protein-coding   GIFtS: 62
GCID: GC01P159173

Duffy Blood Group, Atypical Chemokine Receptor

(Previous names: Duffy blood group, Duffy blood group, chemokine receptor)
(Previous symbol: FY)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Duffy Blood Group, Atypical Chemokine Receptor1 2     WBCQ12 5
FY1 2 3 5     Duffy Blood Group1
GPD2 3 5     ACKR12
Duffy Blood Group, Chemokine Receptor1 2     CCBP12
Atypical Chemokine Receptor 11 2     CD2342
Glycoprotein D2 3     Dfy2
Plasmodium Vivax Receptor2 3     Duffy Antigen/Chemokine Receptor2
GpFy2 3     Duffy Blood Group Antigen2
Fy Glycoprotein2 3     CD234 Antigen3

External Ids:    HGNC: 40351   Entrez Gene: 25322   Ensembl: ENSG000002130887   OMIM: 6136655   UniProtKB: Q165703   

Export aliases for DARC gene to outside databases

Previous GC identifers: GC01P157409 GC01P157440 GC01P130531


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DARC Gene:
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several
chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium
knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for DARC Gene: 
DARC (Duffy blood group, atypical chemokine receptor) is a protein-coding gene. Diseases associated with DARC include genital herpes, and plasmodium vivax malaria, and among its related super-pathways are GPCR ligand binding and GPCR downstream signaling. GO annotations related to this gene include receptor activity and chemokine receptor activity.

UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570
Function: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the
receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi

Gene Wiki entry for DARC (Duffy antigen system) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DARC gene promoter:
         HEN1   MZF-1   LCR-F1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDARC promoter sequence
   Search SABiosciences Chromatin IP Primers for DARC

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DARC


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21-q22   Ensembl cytogenetic band:  1q23.2   HGNC cytogenetic band: 1q21-q22

DARC Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DARC gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P159173:  view genomic region     (about GC identifiers)

Start:
159,173,097 bp from pter      End:
159,176,290 bp from pter
Size:
3,194 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570 (See protein sequence)
Recommended Name: Duffy antigen/chemokine receptor  
Size: 336 amino acids; 35553 Da
Subcellular location: Membrane; Multi-pass membrane protein
Secondary accessions: A8YPG5 O75898 Q16300 Q8WWE3 Q9UJP0 Q9UKZ5 Q9UKZ6 Q9UQE1
Alternative splicing: 2 isoforms:  Q16570-1   Q16570-2   

Explore the universe of human proteins at neXtProt for DARC: NX_Q16570

Explore proteomics data for DARC at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q16570

  • DARC Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DARC Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001116423.1  NP_002027.2  

    ENSEMBL proteins: 
     ENSP00000357104   ENSP00000398406   ENSP00000441985   ENSP00000357103  
    Reactome Protein details: Q16570
    Human Recombinant Protein Products for DARC: 
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    OriGene Protein Over-expression Lysate for DARC
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    Novus Biologicals DARC Proteins
    Novus Biologicals DARC Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DARC 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    DARC for ontologies           About GeneDecksing



    DARC Antibody Products: 
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    Novus Biologicals DARC Antibodies
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    Cloud-Clone Corp. Antibodies for DARC 
    ThermoFisher Antibodies for DARC
    LSBio Antibodies in human, mouse, rat for DARC 

    Assay Products for DARC: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for DARC
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DARC 
    Cloud-Clone Corp. CLIAs for DARC


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CD: CD molecules
    bloodgroup: Blood group antigens
    ACKR: GPCR / Class A : Chemokine receptors : Atypical

    IUPHAR Guide to PHARMACOLOGY protein family classification: DARC 
    Chemokine receptors

    1 InterPro protein domain:
     IPR005384 Duffy_chemokine_rcpt

    Graphical View of Domain Structure for InterPro Entry Q16570

    ProtoNet protein and cluster: Q16570

    1 Blocks protein domain: IPB005384 Duffy antigen/chemokine receptor signature

    UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570
    Similarity: Belongs to the G-protein coupled receptor Duffy family


    DARC for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DUFFY_HUMAN, Q16570
    Function: Non-specific receptor for many chemokines such as IL-8, GRO, RANTES, MCP-1 and TARC. It is also the
    receptor for the human malaria parasites Plasmodium vivax and Plasmodium knowlesi

         Genatlas biochemistry entry for DARC:
    Duffy antigen,receptor for chemokines and plasmodium vivax

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004872receptor activity TAS7689250
    GO:0004888transmembrane signaling receptor activity TAS9058825
    GO:0004950chemokine receptor activity NAS--
    GO:0019956chemokine binding ----
    GO:0019957C-C chemokine binding IPI7517217
         
    DARC for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Darc):
     homeostasis/metabolism  immune system  skeleton 

    DARC for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DARC: Darctm1Scp Darctm1Pogo Darctm1Skmz

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DARC 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DARC

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DARC 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DARC 

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    Inhib. RNA
    Products:
        
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    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DARC

    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): DARC (NM_001122951)
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                         Customized lentivirus expression plasmids for stable overexpression of DARC 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DARC


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DARC About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Class A/1 (Rhodopsin-like receptors)
    Class A/1 (Rhodopsin-like receptors)0.71
    Peptide ligand-binding receptors0.60
    GPCR ligand binding0.71
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    3Neuropeptides signaling through G-protein alpha-i & G-protein alpha-q
    Peptide GPCRs0.46
    4Malaria
    Malaria
    5GPCRs, Other
    GPCRs, Other

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 BioSystems Pathways for DARC
        GPCRs, Other
    Peptide GPCRs

    5        Reactome Pathways for DARC
        Peptide ligand-binding receptors
    Signal Transduction
    Signaling by GPCR
    GPCR ligand binding
    Class A/1 (Rhodopsin-like receptors)


    1         Kegg Pathway  (Kegg details for DARC):
        Malaria


    DARC for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DARC

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    5/10 Interacting proteins for DARC (Q165703 ENSP000003571034) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CCL2P135003, ENSP000002258314I2D: score=4 STRING: ENSP00000225831
    IL8P101453, ENSP000003065124I2D: score=3 STRING: ENSP00000306512
    CCL7P800983, ENSP000002003074I2D: score=2 STRING: ENSP00000200307
    CXCL1P093413, ENSP000003791104I2D: score=3 STRING: ENSP00000379110
    CCL5P135013, ENSP000002932724I2D: score=4 STRING: ENSP00000293272
    About this table

    Gene Ontology (GO): 4 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006952defense response NAS10570183
    GO:0006954inflammatory response IEA--
    GO:0032642regulation of chemokine production IEA--
    GO:0070098chemokine-mediated signaling pathway ----

    DARC for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DARC for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DARC (DUFFY)

    8 Novoseek inferred chemical compound relationships for DARC gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    monophosphoryl lipid a 52.4 4 14711338 (1), 19702506 (1)
    rantes 49.8 6 15572394 (2), 9195930 (1), 10925048 (1), 15720550 (1) (see all 5)
    mannose 6-phosphate 33.7 7 12021353 (1), 9525660 (1), 7745699 (1)
    glyceraldehyde 3-phosphate 3.17 2 1367405 (1), 16153028 (1)
    phenylalanine 0 3 15720550 (3)
    lipid 0 2 17299053 (1), 19786966 (1)
    tyrosine 0 1 7511603 (1)
    alanine 0 4 7744785 (2), 15720551 (1), 12956774 (1)

    Search CenterWatch for drugs/clinical trials and news about DARC / DUFFY

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DARC gene (2 alternative transcripts): 
    NM_001122951.2  NM_002036.3  

    Unigene Cluster for DARC:

    Duffy blood group, chemokine receptor
    Hs.153381  [show with all ESTs]
    Unigene Representative Sequence: NM_002036
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000368122 ENST00000435307 ENST00000537147 ENST00000368121(uc001ftp.4)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    GenScript: all cDNA clones in your preferred vector (see all 2): DARC (NM_001122951)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DARC
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DARC
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DARC
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DARC

    Additional mRNA sequence: 

    AF030521.1 AK291593.1 AK309521.1 AY167991.1 BC017817.1 BC095496.1 BX537430.1 HE572751.1 
    JX081310.1 U01839.1 

    6 DOTS entries:

    DT.421927  DT.100773431  DT.121396982  DT.92419466  DT.95130101  DT.95292525 

    24/264 AceView cDNA sequences (see all 264):

    BU729842 CR605082 BU683321 BU150151 CB154618 BX281058 AW157521 AI318397 
    BM671230 BM972973 AU150243 BM713575 AI564838 CD673597 AY046418 AW170565 
    CR601573 NM_002036 BM704393 AW294540 AF363367 CD676370 BE502006 N47613 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DARC expression in normal human tissues (normalized intensities)      DARC embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCTGGCCCAG
    DARC Expression
    About this image


    DARC expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Proerythroblasts Hematopoietic Bone Marrow
             Bone Marrow CD105+ Cells   
     
     Colon (Gastrointestinal Tract)
             Appendix   
     
     Peripheral Nervous System (Nervous System)
             autonomic/parasympathetic   
     
     Neural Tube (Nervous System)
             Primitive Spinal Cord
     
     Eye (Sensory Organs)
             GABAergic Amacrine Cells Inner Nuclear Layer

    See DARC Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DARC

    SOURCE GeneReport for Unigene cluster: Hs.153381

    UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570
    Tissue specificity: Found in adult kidney, adult spleen, bone marrow and fetal liver. In particular, it is
    expressed along postcapillary venules throughout the body, except in the adult liver. Erythroid cells and
    postcapillary venule endothelium are the principle tissues expressing duffy. Fy(-A-B) individuals do not express
    duffy in the bone marrow, however they do, in postcapillary venule endothelium

        SABiosciences Expression via Pathway-Focused PCR Arrays including DARC: 
              G Protein Coupled Receptors 384HT in human mouse rat
              Chemokines & Receptors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DARC

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DARC gene from 2/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Darc1 , 5 Duffy blood group, chemokine receptor1, 5 71.07(n)1
    60.36(a)1
      1 (80.33 cM)5
    133491  NM_010045.21  NP_034175.21 
     1733318865 
    chicken
    (Gallus gallus)
    Aves DARC6
    Duffy blood group, chemokine receptor
    27(a)
    1 ↔ 1
    25(1672509-1673429)


    ENSEMBL Gene Tree for DARC (if available)
    TreeFam Gene Tree for DARC (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DARC gene
    2 SIMAP similar genes for DARC using alignment to 6 protein entries:     DUFFY_HUMAN (see all proteins):
    FY    DKFZp686D15198

    DARC for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: DUFFY_HUMAN, Q16570
    Polymorphism: DARC is responsible for the Duffy blood group system (FY) [MIM:110700]. The molecular basis of the
    Fy(A)=Fy1/Fy(B)=Fy2 blood group antigens is a single variation in position 42; Gly-42 corresponds to Fy(A) and
    Asp-42 to Fy(B). Individuals that do not produce the Duffy antigen (FY(A-B-)) are more resistant to infection by
    the malarial parasite Plasmodium vivax. This allele is found predominantly in population of African origin
    [MIM:611162]
    Polymorphism: Genetic variations in DARC define the white blood cell count quantitative trait locus 1 (WBCQ1)
    [MIM:611862]. Peripheral white blood cell count (WBC) is a common clinical measurement, used to determine
    evidence of acute infammation or infection. Peripheral WBC is the sum of several cell types including neutrophils
    and lymphocytes, which are the most common types of WBC, as well as less common cell types such as eosinophils,
    basophils, and monocytes. Elevated WBC has been associated with risk of coronary heart disease, cancer, and
    all-cause mortality. White blood cell levels have widespread clinical applications including assessment of
    patients undergoing chemotherapy and evaluation of infection


    10/361 SNPs in DARC are shown (see all 361)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs120751,2,4
    C,F,A,Hnon-pathogenic1165671735(+) CTATGA/GTGCCA 4 D G mis136Minor allele frequency- G:0.38MN NA NS EA WA CSA EU 8963
    rs345990821,2,4
    C,Fpathogenic1165671875(-) CCAGCG/AGAAGA 4 /R /C mis15Minor allele frequency- A:0.01NA EU 5923
    rs413139081,2
    C,F--165668491(+) GAGTCC/TCCGGG 1 -- us2k14Minor allele frequency- T:0.09NA 126
    rs1818076631,2
    --165668609(+) CTATGC/TACCTC 1 -- us2k10--------
    rs354322891,2
    C,F--165668675(+) CATAGT/GCTGTA 1 -- us2k11Minor allele frequency- G:0.00MN 22
    rs1872763401,2
    --165668724(+) GATTTC/TCTGTC 1 -- us2k10--------
    rs1909283481,2
    --165668803(+) TGCCCC/TGCCTC 1 -- us2k10--------
    rs1495999571,2
    C--165668919(+) CACCCC/GCTTCA 1 -- us2k10--------
    rs609253111,2
    C,F--165668957(+) CAGCCG/ACTGGT 1 -- us2k11Minor allele frequency- A:0.50WA 2
    rs1400393731,2
    --165668993(+) CCCTCA/CCCTAA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DARC (159173097 - 159176290 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DARC: --

    Human Gene Mutation Database (HGMD): DARC

    Locus Specific Mutation Databases (LSDB): DARC
    Blood Group Antigen Gene Mutation Database (BGMUT) blood group system
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DARC
    DNA2.0 Custom Variant and Variant Library Synthesis for DARC

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 613665   
    OMIM disorders: 110700  611162  611862  
    20/58 diseases for DARC (see all 58):    About MalaCards
    genital herpes    plasmodium vivax malaria    neonatal herpes    malaria, resistance to
    malaria, vivax, protection against    motor peripheral neuropathy    drug dependence    herpetic keratitis
    meningoencephalitis    rhinotracheitis    herpes simplex    keratitis
    crescentic glomerulonephritis    charcot-marie-tooth disease type 1    hereditary elliptocytosis    hiv/aids
    food allergy    malaria    sickle cell anemia    peripheral neuropathy

    7 diseases from the University of Copenhagen DISEASES database for DARC:
    Herpes simplex     Malaria     Keratitis     Rhinotracheitis
    Hereditary elliptocytosis     Vaccinia     Encephalitis

    DARC for disorders           About GeneDecksing

    10/24 Novoseek inferred disease relationships for DARC gene (see all 24)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    herpes simplex 83.4 75 8388365 (2), 12021353 (2), 7911177 (2), 12885915 (2) (see all 69)
    pseudorabies 67 2 11162814 (1), 15534229 (1)
    genital herpes 64.9 4 7911177 (2), 19702506 (1), 8158042 (1)
    malaria vivax 59.2 3 20162434 (3)
    viral shedding 56.5 1 8158042 (1)
    herpes 54 9 11162814 (1), 18468509 (1), 18358807 (1), 17390046 (1) (see all 6)
    malaria 40.5 7 18621004 (1), 10712211 (1), 15720550 (1), 10960522 (1) (see all 6)
    hemolytic disease 35.4 1 9531948 (1)
    drug addiction 35.1 7 11019561 (2), 17037343 (1), 15675365 (1), 16734277 (1)
    drug dependence 30.6 5 17037343 (3), 11019561 (1), 15160890 (1)

    Genetic Association Database (GAD): DARC
    Human Genome Epidemiology (HuGE) Navigator: DARC (35 documents)

    Export disorders for DARC gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DARC gene, integrated from 9 sources (see all 269):
    (articles sorted by number of sources associating them with DARC)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite. (PubMed id 8248172)1, 2, 3, 9 Chaudhuri A....Pogo A. (1993)
    2. Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals. (PubMed id 7663520)1, 2, 3 Tournamille C....Le Van Kim C. (1995)
    3. Genomic organization of the glycoprotein D gene: Duffy blood group Fya/Fyb alloantigen system is associated with a polymorphism at the 44-amino acid residue. (PubMed id 7833467)1, 2, 9 Iwamoto S.... Ikemoto S. (1995)
    4. Arg89Cys substitution results in very low membrane expression of the Duffy antigen/receptor for chemokines in Fy(x) individuals. (PubMed id 9731074)1, 2, 9 Tournamille C.... Colin Y. (1998)
    5. FY polymorphisms and vivax malaria in inhabitants of Amazonas State, Brazil. (PubMed id 20162434)1, 4, 9 Albuquerque S.R....dos Santos M.C. (2010)
    6. Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean. (PubMed id 18710383)1, 4, 9 Grann V.R....Hershman D.L. (2008)
    7. Structure-function analysis of the extracellular domains of the Duffy antigen/receptor for chemokines: characterization of antibody and chemokine binding sites. (PubMed id 12956774)1, 2, 9 Tournamille C.... Le Van Kim C. (2003)
    8. The Duffy-null state is associated with a survival ad vantage in leukopenic HIV-infected persons of African ancestry. (PubMed id 19620399)1, 4, 9 Kulkarni H....Ahuja S.K. (2009)
    9. Genetic polymorphisms in TLR4, CR1 and Duffy genes are not associated with malaria resistance in patients from Baixo Amazonas region, Brazil. (PubMed id 19048480)1, 4, 9 Soares S.C....Silva W.A. (2008)
    10. Lack of Duffy antigen expression is associated with organ damage in patients with sickle cell disease. (PubMed id 18248572)1, 4, 9 Afenyi-Annan A....Telen M.J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 2532 HGNC: 4035 AceView: FYandIGSF4B Ensembl:ENSG00000213088 euGenes: HUgn2532
    ECgene: DARC Kegg: 2532 H-InvDB: DARC

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DARC Pharmacogenomics, SNPs, Pathways
    dbRBC/BGMUThttp://www.ncbi.nlm.nih.gov/gv/mhc/xslcgi.cgi?cmd=bgmut/systems_info&system=duffy
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DARC
    Wikipedia http://en.wikipedia.org/wiki/Duffy_antigen

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DARC gene:
    Search GeneIP for patents involving DARC

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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