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Aliases for DAPP1 Gene

Aliases for DAPP1 Gene

  • Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides 2 3
  • BAM32 3 4 6
  • B Lymphocyte Adapter Protein Bam32 3 4
  • B-Cell Adapter Molecule Of 32 KDa 3 4
  • HDAPP1 3 4
  • Dual Adapter For Phosphotyrosine And 3-Phosphotyrosine And 3-Phosphoinositide 3

External Ids for DAPP1 Gene

Previous GeneCards Identifiers for DAPP1 Gene

  • GC04P100985
  • GC04P101130
  • GC04P101196
  • GC04P101095
  • GC04P100737
  • GC04P096476

Summaries for DAPP1 Gene

GeneCards Summary for DAPP1 Gene

DAPP1 (Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides) is a Protein Coding gene. Among its related pathways are Downstream Signaling Events Of B Cell Receptor (BCR) and Class I MHC mediated antigen processing and presentation. GO annotations related to this gene include phospholipid binding and phosphatidylinositol-3,4,5-trisphosphate binding.

UniProtKB/Swiss-Prot for DAPP1 Gene

  • May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.

Gene Wiki entry for DAPP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAPP1 Gene

Genomics for DAPP1 Gene

Regulatory Elements for DAPP1 Gene

Genomic Location for DAPP1 Gene

Start:
99,816,824 bp from pter
End:
99,870,190 bp from pter
Size:
53,367 bases
Orientation:
Plus strand

Genomic View for DAPP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAPP1 Gene

Proteins for DAPP1 Gene

  • Protein details for DAPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN19-DAPP1_HUMAN
    Recommended name:
    Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
    Protein Accession:
    Q9UN19
    Secondary Accessions:
    • Q8TCK5
    • Q9UHF2

    Protein attributes for DAPP1 Gene

    Size:
    280 amino acids
    Molecular mass:
    32194 Da
    Quaternary structure:
    • Interacts with PtdIns(3,4,5)P3 and PLCG2. In vitro, interacts with PtdIns(3,4)P2.

    Three dimensional structures from OCA and Proteopedia for DAPP1 Gene

    Alternative splice isoforms for DAPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAPP1 Gene

Proteomics data for DAPP1 Gene at MOPED

Post-translational modifications for DAPP1 Gene

Other Protein References for DAPP1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DAPP1 (DAPP1)

No data available for DME Specific Peptides for DAPP1 Gene

Domains for DAPP1 Gene

Gene Families for DAPP1 Gene

HGNC:
  • PLEKH :Pleckstrin homology (PH) domain containing
  • SH2D :SH2 domain containing

Protein Domains for DAPP1 Gene

Suggested Antigen Peptide Sequences for DAPP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UN19

UniProtKB/Swiss-Prot:

DAPP1_HUMAN :
  • Q9UN19
Domain:
  • Contains 1 PH domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with DAPP1: view

Function for DAPP1 Gene

Molecular function for DAPP1 Gene

UniProtKB/Swiss-Prot Function: May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
UniProtKB/Swiss-Prot Induction: Upon B-cell activation

Gene Ontology (GO) - Molecular Function for DAPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005543 phospholipid binding NAS 10432293
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 11001876
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA 17823121
genes like me logo Genes that share ontologies with DAPP1: view

Phenotypes for DAPP1 Gene

genes like me logo Genes that share phenotypes with DAPP1: view

Animal Models for DAPP1 Gene

MGI Knock Outs for DAPP1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DAPP1 Gene

Localization for DAPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAPP1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAPP1 Gene COMPARTMENTS Subcellular localization image for DAPP1 gene
Compartment Confidence
plasma membrane 5
cytosol 4
nucleus 2
cytoskeleton 1

Gene Ontology (GO) - Cellular Components for DAPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with DAPP1: view

Pathways for DAPP1 Gene

genes like me logo Genes that share pathways with DAPP1: view

Gene Ontology (GO) - Biological Process for DAPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation NAS 10432293
GO:0007165 signal transduction TAS 10432293
genes like me logo Genes that share ontologies with DAPP1: view

Compounds for DAPP1 Gene

(1) Drugbank Compounds for DAPP1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Inositol 1,3,4,5-Tetrakisphosphate
target

(1) Novoseek inferred chemical compound relationships for DAPP1 Gene

Compound -log(P) Hits PubMed IDs
phosphatidylinositol 55.4 1
genes like me logo Genes that share compounds with DAPP1: view

Transcripts for DAPP1 Gene

Unigene Clusters for DAPP1 Gene

Dual adaptor of phosphotyrosine and 3-phosphoinositides:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAPP1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAPP1 Gene

No ASD Table

Relevant External Links for DAPP1 Gene

GeneLoc Exon Structure for
DAPP1
ECgene alternative splicing isoforms for
DAPP1

Expression for DAPP1 Gene

mRNA expression in normal human tissues for DAPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAPP1 Gene

This gene is overexpressed in Esophagus - Mucosa (8.1) and Whole Blood (7.9).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DAPP1 Gene

SOURCE GeneReport for Unigene cluster for DAPP1 Gene Hs.436271

mRNA Expression by UniProt/SwissProt for DAPP1 Gene

Q9UN19-DAPP1_HUMAN
Tissue specificity: Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.
genes like me logo Genes that share expressions with DAPP1: view

In Situ Assay Products

Orthologs for DAPP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DAPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAPP1 35
  • 99.88 (n)
  • 100 (a)
DAPP1 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DAPP1 35
  • 91.19 (n)
  • 95.71 (a)
DAPP1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAPP1 35
  • 92.74 (n)
  • 97.5 (a)
DAPP1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dapp1 35
  • 87.74 (n)
  • 93.21 (a)
Dapp1 16
Dapp1 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DAPP1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAPP1 36
  • 78 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dapp1 35
  • 85.9 (n)
  • 92.11 (a)
chicken
(Gallus gallus)
Aves DAPP1 35
  • 75.58 (n)
  • 86.01 (a)
DAPP1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DAPP1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dapp1 35
  • 73.87 (n)
  • 78.39 (a)
zebrafish
(Danio rerio)
Actinopterygii dapp1 35
  • 66.26 (n)
  • 72.84 (a)
dapp1 36
  • 70 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8525 36
  • 50 (a)
OneToOne
Species with no ortholog for DAPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DAPP1 Gene

ENSEMBL:
Gene Tree for DAPP1 (if available)
TreeFam:
Gene Tree for DAPP1 (if available)

Paralogs for DAPP1 Gene

Selected SIMAP similar genes for DAPP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DAPP1: view

No data available for Paralogs for DAPP1 Gene

Variants for DAPP1 Gene

Sequence variations from dbSNP and Humsavar for DAPP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs12431 -- 99,869,383(+) AGATA(A/G)AAGTT utr-variant-3-prime
rs15924 -- 99,869,150(-) CAATG(C/T)GAGAT utr-variant-3-prime
rs767652 -- 99,870,648(-) CTGCC(A/G)TTGGC downstream-variant-500B
rs890485 -- 99,860,886(-) TAAGG(G/T)TGGAG intron-variant
rs890486 -- 99,860,880(-) TGGAG(A/G)ATTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAPP1 Gene

Variant ID Type Subtype PubMed ID
esv270372 CNV Insertion 20981092
nsv520074 CNV Loss 19592680

Relevant External Links for DAPP1 Gene

HapMap Linkage Disequilibrium report
DAPP1
Human Gene Mutation Database (HGMD)
DAPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAPP1 Gene

Disorders for DAPP1 Gene

No disorders were found for DAPP1 Gene.

No data available for UniProtKB/Swiss-Prot for DAPP1 Gene

Publications for DAPP1 Gene

  1. A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3- kinase. (PMID: 10770799) Marshall A.J. … Clark E.A. (J. Exp. Med. 2000) 3 4 23
  2. DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. (PMID: 10432293) Dowler S. … Alessi D.R. (Biochem. J. 1999) 2 3 4
  3. Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. (PMID: 10983984) Ferguson K.M. … Lemmon M.A. (Mol. Cell 2000) 3 4
  4. Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PMID: 11042152) Zhang Q.-H. … Chen Z. (Genome Res. 2000) 3 4
  5. The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism. (PMID: 15247305) Allam A. … Marshall A.J. (J. Biol. Chem. 2004) 3 23

Products for DAPP1 Gene

Sources for DAPP1 Gene

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