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Aliases for DAPP1 Gene

Aliases for DAPP1 Gene

  • Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides 1 2 3 5
  • B Lymphocyte Adapter Protein Bam32 3 4
  • B-Cell Adapter Molecule Of 32 KDa 3 4
  • HDAPP1 3 4
  • BAM32 3 4
  • Dual Adapter For Phosphotyrosine And 3-Phosphotyrosine And 3-Phosphoinositide 3

External Ids for DAPP1 Gene

Previous GeneCards Identifiers for DAPP1 Gene

  • GC04P100985
  • GC04P101130
  • GC04P101196
  • GC04P101095
  • GC04P100737
  • GC04P096476

Summaries for DAPP1 Gene

GeneCards Summary for DAPP1 Gene

DAPP1 (Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides 1) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I PI3K signaling events. GO annotations related to this gene include phospholipid binding and phosphatidylinositol-3,4-bisphosphate binding.

UniProtKB/Swiss-Prot for DAPP1 Gene

  • May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.

Gene Wiki entry for DAPP1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAPP1 Gene

Genomics for DAPP1 Gene

Regulatory Elements for DAPP1 Gene

Enhancers for DAPP1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G099845 1.7 FANTOM5 Ensembl ENCODE dbSUPER 22.9 +29.8 29810 3.3 HDGF TBL1XR1 WRNIP1 BMI1 RCOR1 ETV6 RELB IKZF2 CREM CBFB DAPP1 TRMT10A MTTP LAMTOR3 DNAJB14 ENSG00000279913
GH04G099841 0.7 FANTOM5 dbSUPER 32.5 +24.6 24609 0.3 MEF2D DAPP1 TRMT10A MTTP LAMTOR3 ENSG00000279913 LOC285556
GH04G099819 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.7 +4.6 4608 3.2 TBP CTCF CBX3 TAL1 RAD21 CBX5 EED FOS ETV6 TRIM24 DNAJB14 TRMT10A DAPP1 H2AFZ MTTP LOC256880 LAMTOR3 DDIT4L LOC285556
GH04G099814 1.4 FANTOM5 ENCODE dbSUPER 14.3 +0.1 105 4.1 HDGF TBP PKNOX1 FOXA2 TBL1XR1 WRNIP1 SIN3A RAD21 ZBTB40 YY1 DAPP1 TRMT10A MTTP DNAJB14 H2AFZ LOC256880 LAMTOR3 LOC285556
GH04G099842 1.3 ENCODE dbSUPER 11.7 +25.8 25849 1.3 PKNOX1 ATF1 CREB3L1 ARNT E2F7 TCF12 ZNF766 ELK1 GATA2 NCOA1 DAPP1 MTTP TRMT10A DNAJB14 ENSG00000279913 LOC285556
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DAPP1 on UCSC Golden Path with GeneCards custom track

Promoters for DAPP1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000171115 376 801 HDGF TBP PKNOX1 TBL1XR1 WRNIP1 SIN3A RAD21 GATA2 ZNF143 RCOR1

Genomic Location for DAPP1 Gene

Chromosome:
4
Start:
99,816,824 bp from pter
End:
99,872,249 bp from pter
Size:
55,426 bases
Orientation:
Plus strand

Genomic View for DAPP1 Gene

Genes around DAPP1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAPP1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAPP1 Gene

Proteins for DAPP1 Gene

  • Protein details for DAPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN19-DAPP1_HUMAN
    Recommended name:
    Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
    Protein Accession:
    Q9UN19
    Secondary Accessions:
    • Q8TCK5
    • Q9UHF2

    Protein attributes for DAPP1 Gene

    Size:
    280 amino acids
    Molecular mass:
    32194 Da
    Quaternary structure:
    • Interacts with PtdIns(3,4,5)P3 and PLCG2. In vitro, interacts with PtdIns(3,4)P2.

    Three dimensional structures from OCA and Proteopedia for DAPP1 Gene

    Alternative splice isoforms for DAPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAPP1 Gene

Post-translational modifications for DAPP1 Gene

Other Protein References for DAPP1 Gene

No data available for DME Specific Peptides for DAPP1 Gene

Domains & Families for DAPP1 Gene

Protein Domains for DAPP1 Gene

Suggested Antigen Peptide Sequences for DAPP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DAPP1: view

No data available for UniProtKB/Swiss-Prot for DAPP1 Gene

Function for DAPP1 Gene

Molecular function for DAPP1 Gene

UniProtKB/Swiss-Prot Function:
May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
UniProtKB/Swiss-Prot Induction:
Upon B-cell activation.

Gene Ontology (GO) - Molecular Function for DAPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25814554
GO:0005543 phospholipid binding NAS 10432293
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 11001876
GO:0030165 PDZ domain binding IBA --
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA 17823121
genes like me logo Genes that share ontologies with DAPP1: view
genes like me logo Genes that share phenotypes with DAPP1: view

Animal Models for DAPP1 Gene

MGI Knock Outs for DAPP1:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for DAPP1 Gene

Localization for DAPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAPP1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAPP1 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 2

Gene Ontology (GO) - Cellular Components for DAPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with DAPP1: view

Pathways & Interactions for DAPP1 Gene

genes like me logo Genes that share pathways with DAPP1: view

Pathways by source for DAPP1 Gene

Gene Ontology (GO) - Biological Process for DAPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation NAS 10432293
GO:0007165 signal transduction TAS 10432293
genes like me logo Genes that share ontologies with DAPP1: view

No data available for SIGNOR curated interactions for DAPP1 Gene

Drugs & Compounds for DAPP1 Gene

(1) Drugs for DAPP1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
inositol 1,3,4,5-tetrakisphosphate Experimental Pharma Target 0

(1) Additional Compounds for DAPP1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DAPP1: view

Transcripts for DAPP1 Gene

Unigene Clusters for DAPP1 Gene

Dual adaptor of phosphotyrosine and 3-phosphoinositides:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DAPP1 Gene

No ASD Table

Relevant External Links for DAPP1 Gene

GeneLoc Exon Structure for
DAPP1
ECgene alternative splicing isoforms for
DAPP1

Expression for DAPP1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DAPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAPP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x8.1) and Whole Blood (x7.9).

Protein differential expression in normal tissues from HIPED for DAPP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (44.1) and Platelet (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DAPP1 Gene



Protein tissue co-expression partners for DAPP1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DAPP1 Gene:

DAPP1

SOURCE GeneReport for Unigene cluster for DAPP1 Gene:

Hs.436271

mRNA Expression by UniProt/SwissProt for DAPP1 Gene:

Q9UN19-DAPP1_HUMAN
Tissue specificity: Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.

Evidence on tissue expression from TISSUES for DAPP1 Gene

  • Blood(4.4)
  • Lymph node(4.4)
genes like me logo Genes that share expression patterns with DAPP1: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for DAPP1 Gene

Orthologs for DAPP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DAPP1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAPP1 34 35
  • 99.88 (n)
dog
(Canis familiaris)
Mammalia DAPP1 34 35
  • 92.74 (n)
cow
(Bos Taurus)
Mammalia DAPP1 34 35
  • 91.19 (n)
mouse
(Mus musculus)
Mammalia Dapp1 34 16 35
  • 87.74 (n)
rat
(Rattus norvegicus)
Mammalia Dapp1 34
  • 85.9 (n)
oppossum
(Monodelphis domestica)
Mammalia DAPP1 35
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAPP1 35
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAPP1 34 35
  • 75.58 (n)
lizard
(Anolis carolinensis)
Reptilia DAPP1 35
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dapp1 34
  • 73.87 (n)
zebrafish
(Danio rerio)
Actinopterygii dapp1 34 35
  • 66.26 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8525 35
  • 50 (a)
OneToOne
Species where no ortholog for DAPP1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DAPP1 Gene

ENSEMBL:
Gene Tree for DAPP1 (if available)
TreeFam:
Gene Tree for DAPP1 (if available)

Paralogs for DAPP1 Gene

(2) SIMAP similar genes for DAPP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DAPP1: view

No data available for Paralogs for DAPP1 Gene

Variants for DAPP1 Gene

Sequence variations from dbSNP and Humsavar for DAPP1 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000076478 -- 99,824,383(+) TGATG(A/G)TGTAC intron-variant
rs1000169571 -- 99,861,702(+) CTTGA(C/T)AGTTT intron-variant
rs1000178676 -- 99,819,469(+) GATAC(A/C)TTTTT intron-variant
rs1000255127 -- 99,853,690(+) GCATG(-/CA)CACCT intron-variant
rs1000273184 -- 99,855,164(+) CAATT(C/G)TTGTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAPP1 Gene

Variant ID Type Subtype PubMed ID
dgv2865n106 CNV tandem duplication 24896259
esv3306095 CNV mobile element insertion 20981092
esv3357480 CNV insertion 20981092
nsv1136895 CNV deletion 24896259
nsv520074 CNV loss 19592680

Variation tolerance for DAPP1 Gene

Residual Variation Intolerance Score: 38.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAPP1 Gene

Human Gene Mutation Database (HGMD)
DAPP1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAPP1 Gene

Disorders for DAPP1 Gene

Relevant External Links for DAPP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAPP1

No disorders were found for DAPP1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DAPP1 Gene

Publications for DAPP1 Gene

  1. A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3- kinase. (PMID: 10770799) Marshall A.J. … Clark E.A. (J. Exp. Med. 2000) 3 4 22 64
  2. DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. (PMID: 10432293) Dowler S. … Alessi D.R. (Biochem. J. 1999) 2 3 4 64
  3. Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains. (PMID: 17823121) Manna D. … Cho W. (J. Biol. Chem. 2007) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism. (PMID: 15247305) Allam A. … Marshall A.J. (J. Biol. Chem. 2004) 3 22 64

Products for DAPP1 Gene

Sources for DAPP1 Gene

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