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Aliases for DAPP1 Gene

Aliases for DAPP1 Gene

  • Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides 2 3
  • B Lymphocyte Adapter Protein Bam32 3 4
  • B-Cell Adapter Molecule Of 32 KDa 3 4
  • HDAPP1 3 4
  • BAM32 3 4

External Ids for DAPP1 Gene

Previous GeneCards Identifiers for DAPP1 Gene

  • GC04P100985
  • GC04P101130
  • GC04P101196
  • GC04P101095
  • GC04P100737
  • GC04P096476

Summaries for DAPP1 Gene

GeneCards Summary for DAPP1 Gene

DAPP1 (Dual Adaptor Of Phosphotyrosine And 3-Phosphoinositides) is a Protein Coding gene. Among its related pathways are Immune System and Downstream signaling events of B Cell Receptor (BCR). GO annotations related to this gene include phospholipid binding and phosphatidylinositol-3,4-bisphosphate binding.

UniProtKB/Swiss-Prot for DAPP1 Gene

  • May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.

Gene Wiki entry for DAPP1 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAPP1 Gene

Genomics for DAPP1 Gene

Regulatory Elements for DAPP1 Gene

Genomic Location for DAPP1 Gene

Chromosome:
4
Start:
99,816,824 bp from pter
End:
99,872,249 bp from pter
Size:
55,426 bases
Orientation:
Plus strand

Genomic View for DAPP1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAPP1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAPP1 Gene

Proteins for DAPP1 Gene

  • Protein details for DAPP1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UN19-DAPP1_HUMAN
    Recommended name:
    Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide
    Protein Accession:
    Q9UN19
    Secondary Accessions:
    • Q8TCK5
    • Q9UHF2

    Protein attributes for DAPP1 Gene

    Size:
    280 amino acids
    Molecular mass:
    32194 Da
    Quaternary structure:
    • Interacts with PtdIns(3,4,5)P3 and PLCG2. In vitro, interacts with PtdIns(3,4)P2.

    Three dimensional structures from OCA and Proteopedia for DAPP1 Gene

    Alternative splice isoforms for DAPP1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAPP1 Gene

Proteomics data for DAPP1 Gene at MOPED

Post-translational modifications for DAPP1 Gene

Other Protein References for DAPP1 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DAPP1 (DAPP1)

No data available for DME Specific Peptides for DAPP1 Gene

Domains & Families for DAPP1 Gene

Protein Domains for DAPP1 Gene

Suggested Antigen Peptide Sequences for DAPP1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UN19

UniProtKB/Swiss-Prot:

DAPP1_HUMAN :
  • Contains 1 PH domain.
Domain:
  • Contains 1 PH domain.
  • Contains 1 SH2 domain.
genes like me logo Genes that share domains with DAPP1: view

Function for DAPP1 Gene

Molecular function for DAPP1 Gene

UniProtKB/Swiss-Prot Function:
May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3K.
UniProtKB/Swiss-Prot Induction:
Upon B-cell activation

Gene Ontology (GO) - Molecular Function for DAPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25814554
GO:0005543 phospholipid binding NAS 10432293
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding IDA 11001876
GO:0043325 phosphatidylinositol-3,4-bisphosphate binding IDA 17823121
genes like me logo Genes that share ontologies with DAPP1: view
genes like me logo Genes that share phenotypes with DAPP1: view

Animal Models for DAPP1 Gene

MGI Knock Outs for DAPP1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targets and HOMER Transcription for DAPP1 Gene

Localization for DAPP1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAPP1 Gene

Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAPP1 Gene COMPARTMENTS Subcellular localization image for DAPP1 gene
Compartment Confidence
plasma membrane 5
cytosol 4

Gene Ontology (GO) - Cellular Components for DAPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane TAS --
genes like me logo Genes that share ontologies with DAPP1: view

Pathways & Interactions for DAPP1 Gene

genes like me logo Genes that share pathways with DAPP1: view

Pathways by source for DAPP1 Gene

Gene Ontology (GO) - Biological Process for DAPP1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006470 protein dephosphorylation NAS 10432293
GO:0007165 signal transduction TAS 10432293
genes like me logo Genes that share ontologies with DAPP1: view

No data available for SIGNOR curated interactions for DAPP1 Gene

Drugs & Compounds for DAPP1 Gene

(1) Drugs for DAPP1 Gene - From: DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
inositol 1,3,4,5-tetrakisphosphate Experimental Pharma Target 0

(1) Additional Compounds for DAPP1 Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Phosphatidylinositol
genes like me logo Genes that share compounds with DAPP1: view

Transcripts for DAPP1 Gene

Unigene Clusters for DAPP1 Gene

Dual adaptor of phosphotyrosine and 3-phosphoinositides:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAPP1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAPP1 Gene

No ASD Table

Relevant External Links for DAPP1 Gene

GeneLoc Exon Structure for
DAPP1
ECgene alternative splicing isoforms for
DAPP1

Expression for DAPP1 Gene

mRNA expression in normal human tissues for DAPP1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAPP1 Gene

This gene is overexpressed in Esophagus - Mucosa (x8.1) and Whole Blood (x7.9).

Protein differential expression in normal tissues from HIPED for DAPP1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (44.1) and Platelet (19.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DAPP1 Gene



SOURCE GeneReport for Unigene cluster for DAPP1 Gene Hs.436271

mRNA Expression by UniProt/SwissProt for DAPP1 Gene

Q9UN19-DAPP1_HUMAN
Tissue specificity: Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells.
genes like me logo Genes that share expression patterns with DAPP1: view

Protein tissue co-expression partners for DAPP1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for DAPP1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DAPP1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DAPP1 35
  • 91.19 (n)
  • 95.71 (a)
DAPP1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAPP1 35
  • 92.74 (n)
  • 97.5 (a)
DAPP1 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dapp1 35
  • 87.74 (n)
  • 93.21 (a)
Dapp1 16
Dapp1 36
  • 93 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DAPP1 35
  • 99.88 (n)
  • 100 (a)
DAPP1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dapp1 35
  • 85.9 (n)
  • 92.11 (a)
oppossum
(Monodelphis domestica)
Mammalia DAPP1 36
  • 85 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAPP1 36
  • 78 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAPP1 35
  • 75.58 (n)
  • 86.01 (a)
DAPP1 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DAPP1 36
  • 77 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dapp1 35
  • 73.87 (n)
  • 78.39 (a)
zebrafish
(Danio rerio)
Actinopterygii dapp1 35
  • 66.26 (n)
  • 72.84 (a)
dapp1 36
  • 70 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.8525 36
  • 50 (a)
OneToOne
Species with no ortholog for DAPP1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DAPP1 Gene

ENSEMBL:
Gene Tree for DAPP1 (if available)
TreeFam:
Gene Tree for DAPP1 (if available)

Paralogs for DAPP1 Gene

(2) SIMAP similar genes for DAPP1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DAPP1: view

No data available for Paralogs for DAPP1 Gene

Variants for DAPP1 Gene

Structural Variations from Database of Genomic Variants (DGV) for DAPP1 Gene

Variant ID Type Subtype PubMed ID
esv270372 CNV Insertion 20981092
nsv520074 CNV Loss 19592680

Variation tolerance for DAPP1 Gene

Residual Variation Intolerance Score: 38.39% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.37; 8.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAPP1 Gene

HapMap Linkage Disequilibrium report
DAPP1
Human Gene Mutation Database (HGMD)
DAPP1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for DAPP1 Gene

Disorders for DAPP1 Gene

Relevant External Links for DAPP1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAPP1
genes like me logo Genes that share disorders with DAPP1: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DAPP1 Gene

Publications for DAPP1 Gene

  1. Regulation of B-lymphocyte activation by the PH domain adaptor protein Bam32/DAPP1. (PMID: 17371232) Marshall A.J. … Al-Alwan M. (Biochem. Soc. Trans. 2007) 23 67
  2. Mechanistic basis of differential cellular responses of phosphatidylinositol 3,4-bisphosphate- and phosphatidylinositol 3,4,5-trisphosphate-binding pleckstrin homology domains. (PMID: 17823121) Manna D. … Cho W. (J. Biol. Chem. 2007) 23 67
  3. Regulation of phosphoinositide 3-kinase signaling by oxidants: hydrogen peroxide selectively enhances immunoreceptor-induced recruitment of phosphatidylinositol (3,4) bisphosphate-binding PH domain proteins. (PMID: 17215104) Cheung S.M. … Marshall A.J. (Cell. Signal. 2007) 23 67
  4. The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism. (PMID: 15247305) Allam A. … Marshall A.J. (J. Biol. Chem. 2004) 23 67
  5. A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3- kinase. (PMID: 10770799) Marshall A.J. … Clark E.A. (J. Exp. Med. 2000) 23 67

Products for DAPP1 Gene

Sources for DAPP1 Gene

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