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Aliases & Descriptions for DAPP1
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| BAM32 1, 2, 3, 5 | | DKFZp667E0716 2 | | hDAPP1 3 |
| | | Descriptions |
|---|
| B lymphocyte adapter protein Bam32 3 | | B-cell adapter molecule of 32 kDa 3 | | dual adaptor of phosphotyrosine and 3-phosphoinositides 2 |
|
| | Search outside databases for aliases for DAPP1 genePrevious GC identifers: GC04P101130 GC04P101196 GC04P101095 |
Summaries for DAPP1(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: DAPP1_HUMAN, Q9UN19Function: May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3KGene Wiki entry for DAPP1 |
Genomic Location for DAPP1
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the DAPP1 gene 
Entrez Gene cytogenetic band: 4q25-q27 Ensembl cytogenetic band: 4q23 HGNC cytogenetic band: 4q25-q27DAPP1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P100985:
(about GC identifiers)
Start:
|
100,957,004 bp from pter |
End:
|
101,010,367 bp from pter |
Size:
|
53,364 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000004.10 NT_016354.18
| Proteins for DAPP1
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: DAPP1_HUMAN, Q9UN19 (See
protein sequence)Recommended Name: Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide Size: 280 amino acids; 32194 Da
Subunit: Interacts with PtdIns(3,4,5)P3 and PLCG2. In vitro, interacts with PtdIns(3,4)P2
Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Note=Membrane-associated after cell stimulation leading to its translocation
PDB structure from and Proteopedia :1FAO (3D)
 1FB8 (3D)
 
Secondary accessions: Q8TCK5 Q9UHF2Alternative splicing: 2 isoforms: Q9UN19-1 Q9UN19-2 Post-translational modifications:
Phosphorylated on tyrosine residues1
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_055210.2
ENSEMBL proteins: ENSP00000296414
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: DAPP1 
3 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for DAPP1: Assays for DAPP1: | Protein
Domains/ Families for DAPP1(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry Q9UN19
ProtoNet protein and cluster: Q9UN19 2 Blocks protein families: IPB000980 SH2 domain signature IPB001849 Pleckstrin-like
UniProtKB/Swiss-Prot: DAPP1_HUMAN, Q9UN19Similarity: Contains 1 PH domainSimilarity: Contains 1 SH2 domain | Gene Function for DAPP1
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014395
Applied Biosystems Silencer® siRNAs for DAPP1
Sigma-Aldrich siRNA and siRNA Panels for DAPP1  Sigma-Aldrich shRNA Panels and shRNA for DAPP1  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_014395                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014395                                  untagged cDNA clone in CMV expression vector: NM_014395 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_014395
UniProtKB/Swiss-Prot: DAPP1_HUMAN, Q9UN19Function: May act as a B-cell-associated adapter that regulates B-cell antigen receptor (BCR)-signaling downstream of PI3KInduction: Upon B-cell activation2 MGI mutant phenotypes (inferred from 2 alleles ) (MGI details for Dapp1):
3 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for DAPP1
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| 1 Sigma-Aldrich "Your Favorite Gene" Pathway for DAPP1 (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for DAPP1 
5/18 Interacting proteins for DAPP1 (ENSP000002964143 Q9UN192) via UniProtKB, MINT, and/or STRING (see all 18
)About this table
2 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for DAPP1(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for DAPP1 1 Novoseek chemical compound relationship for DAPP1 gene
About this table
|
Transcripts for DAPP1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_014395
Sigma-Aldrich siRNA and siRNA Panels for DAPP1  Sigma-Aldrich shRNA Panels and shRNA for DAPP1  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_014395 REFSEQ mRNAs for DAPP1 gene: NM_014395.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_014395               OriGene GFP tagged cDNA clone in CMV expression vector: NM_014395                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_014395                                  untagged cDNA clone in CMV expression vector: NM_014395  Additional cDNA sequence: AF161551.1 AF163254.1 AF178987.1 AF186022.1 AK301355.1 AL713793.1 BC012924.1 5 DOTS entries: DT.115326 DT.95371754 DT.109581 DT.100713958 DT.99936868 24/98 AceView cDNA sequences (see all 98
):AI128099 AF178987 AA934575 AI494139 CA428013 BI224992 CD365738 AI499165 AA418849 AF150266 AI376097 AA251556 AI632216 Z41202 BF516578 AA806554 AA459342 AI206889 AA809680 AI285859 BX118264 BM922611 BG288385 AA459123
highest scoring ESTs for DAPP1:AF150266 AA035041 AA035552 AA043834 AA043835 AA058872 AA149488 AA149813 AA149834 AA149861 Unigene Cluster for DAPP1: Dual adaptor of phosphotyrosine and 3-phosphoinositides Hs.436271 [show with all ESTs]Unigene Representative Sequence: NM_014395
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000296414
|
Expression for DAPP1
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| DAPP1 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for DAPP1
1 / 2 / 3 7 probe-sets matching DAPP1 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: AACGACGCTC
SOURCE GeneReport for Unigene cluster: Hs.436271 UniProtKB/Swiss-Prot: DAPP1_HUMAN, Q9UN19Tissue specificity: Highly expressed in placenta and lung, followed by brain, heart, kidney, liver, pancreas and skeletal muscle. Expressed by B-lymphocytes, but not T-lymphocytes or nonhematopoietic cells |
Orthologs for DAPP1
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DAPP1 gene from 5/7 species (see all 7
)
About this table Species with no ortholog for DAPP1
ENSEMBL Gene Tree for DAPP1 | Paralogs for DAPP1(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for DAPP1(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for DAPP1 (up to first 250kb)
|
Disorders & Mutations for DAPP1
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 605768
|
Medical News for DAPP1(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for DAPP1 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/20 PubMed articles for DAPP1 gene (see all 20
):- DAPP1: a dual adaptor for phosphotyrosine and 3-phosphoinositides. (PubMed id 10432293)2, 3, 4 Dowler S.... Alessi D.R. (1999)
- A novel B lymphocyte-associated adaptor protein, Bam32, regulates antigen receptor signaling downstream of phosphatidylinositol 3- kinase. (PubMed id 10770799)1, 3, 4 Marshall A.J.... Clark E.A. (2000)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. (PubMed id 11042152)3, 4 Zhang Q.H....Chen Z. (2000)
- Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains. (PubMed id 10983984)3, 4 Ferguson K.M.... Lemmon M.A. (2000)
- The adaptor protein Bam32 regulates Rac1 activation and actin remodeling through a phosphorylation-dependent mechanism. (PubMed id 15247305)1, 3 Allam A....Marshall A.J. (2004)
- Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer. (PubMed id 18083107)4 Rikova K....Comb M.J. (2007)
- The full-ORF clone resource of the German cDNA Consortium. (PubMed id 17974005)4 Bechtel S....Schupp I. (2007)
- The B lymphocyte adaptor molecule of 32 kilodaltons (Bam32) regulates B cell antigen receptor internalization. (PubMed id 15494510)3 Niiro H....Clark E.A. (2004)
- Bam32 links the B cell receptor to ERK and JNK and mediates B cell proliferation but not survival. (PubMed id 14563325)3 Han A....Nussenzweig M.C. (2003)
|
Search for DAPP1
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DAPP1
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing DAPP1
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DAPP1(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| --
| Services for DAPP1(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
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Incremental update: 13 Oct 2009
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