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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAPL1 Gene

protein-coding   GIFtS: 44
GCID: GC02P159651

Death Associated Protein-Like 1

  Search for DAPL1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Death Associated Protein-Like 11 2
Early Epithelial Differentiation-Associated Protein2 3
Death-Associated Protein-Like 12
EEDA3

External Ids:    HGNC: 214901   Entrez Gene: 921962   Ensembl: ENSG000001633317   UniProtKB: A0PJW83   

Export aliases for DAPL1 gene to outside databases

Previous GC identifers: GC00U911651 GC02U900711 GC02P159361 GC02P151540


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DAPL1 Gene: 
DAPL1 (death associated protein-like 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: DAPL1_HUMAN, A0PJW8
Function: May play a role in the early stages of epithelial differentiation or in apoptosis (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAPL1 gene promoter:
         GR   p53   GR-beta   POU3F1   MIF-1   Evi-1   COMP1   FOXO1a   GR-alpha   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAPL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DAPL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAPL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.1   Ensembl cytogenetic band:  2q24.1   HGNC cytogenetic band: 2q24

DAPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAPL1 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P159651:  view genomic region     (about GC identifiers)

Start:
159,651,829 bp from pter      End:
159,719,293 bp from pter
Size:
67,465 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DAPL1_HUMAN, A0PJW8 (See protein sequence)
Recommended Name: Death-associated protein-like 1  
Size: 107 amino acids; 11880 Da
Secondary accessions: A0PJW9 B9EIK6

Explore the universe of human proteins at neXtProt for DAPL1: NX_A0PJW8

Explore proteomics data for DAPL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A0PJW8

  • DAPL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DAPL1 Protein Expression
    REFSEQ proteins: NP_001017920.2  
    ENSEMBL proteins: 
     ENSP00000309538   ENSP00000386422   ENSP00000385306  

    Human Recombinant Protein Products for DAPL1: 
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    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane ----

    DAPL1 for ontologies           About GeneDecksing



    DAPL1 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR024130 DAP1/DAPL1

    Graphical View of Domain Structure for InterPro Entry A0PJW8

    ProtoNet protein and cluster: A0PJW8


    DAPL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAPL1_HUMAN, A0PJW8
    Function: May play a role in the early stages of epithelial differentiation or in apoptosis (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004930G-protein coupled receptor activity ----
         
    DAPL1 for ontologies           About GeneDecksing


    Phenotypes:
         3 GenomeRNAi human phenotypes for DAPL1:
     Increased S DNA content  Increased cell size  S arrest 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DAPL1 
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    Inhib. RNA
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAPL1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DAPL1

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process IEA--
    GO:0007186G-protein coupled receptor signaling pathway ----
    GO:0030154cell differentiation IEA--

    DAPL1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DAPL1

    Search CenterWatch for drugs/clinical trials and news about DAPL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DAPL1 gene: 
    NM_001017920.2  

    Unigene Cluster for DAPL1:

    Death associated protein-like 1
    Hs.59761  [show with all ESTs]
    Unigene Representative Sequence: HQ179937
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000309950(uc002uaf.3) ENST00000409042 ENST00000343761
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidDAPL1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DAPL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAPL1
    Clone
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    OriGene clones in human, mouse for DAPL1 (see all 6)
    OriGene ORF clones in mouse, rat for DAPL1
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    GenScript: all cDNA clones in your preferred vector: DAPL1 (NM_001017920)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAPL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAPL1
    Sirion Biotech Customized lentivirus for stable overexpression of DAPL1 
                         Customized lentivirus expression plasmids for stable overexpression of DAPL1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DAPL1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DAPL1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAPL1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAPL1

    Additional mRNA sequence: 

    AF086541.1 AY324399.1 BC127682.1 BC127683.1 BC140719.1 HQ179934.1 HQ179935.1 HQ179936.1 
    HQ179937.1 HQ179938.1 HQ179939.1 

    2 DOTS entries:

    DT.212081  DT.99935740 

    24/37 AceView cDNA sequences (see all 37):

    C00396 AA365503 AA365801 AA453863 AI692575 AA732993 BG818506 BM129664 
    AI632902 AA365504 AW131631 AF086541 AA975337 AA442475 BX117859 BQ189090 
    CD675155 AA453779 CK299997 BQ185417 BQ186911 W96131 AA988869 BM129377 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAPL1 expression in normal human tissues (normalized intensities)      DAPL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCGCATCAAA
    DAPL1 Expression
    About this image


    DAPL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/5 selected tissues (see all 5) fully expand
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human Lens Epithelial Cells (HLEpiC)   
     
     Epithelium (Uncategorized)    fully expand to see all 2 entries
             Human Lens Epithelial Cells (HLEpiC)   
     
     Adipose (Muscoskeletal System)
             Body Subcutaneous White Adipose
     
     Gonad
             Primordial Germ Cells Allantois
     
     Placenta (Extraembryonic Tissues)
             Primordial Germ Cells Allantois

    See DAPL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAPL1

    SOURCE GeneReport for Unigene cluster: Hs.59761

    UniProtKB/Swiss-Prot: DAPL1_HUMAN, A0PJW8
    Tissue specificity: Expressed in hair follicle (at protein level)

        SABiosciences Custom PCR Arrays for DAPL1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAPL1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAPL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DAPL1 gene from 4/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dapl11 , 5 death associated protein-like 11, 5 82.87(n)1
    81.31(a)1
      2 (33.81 cM)5
    767471  NM_029723.31  NP_083999.11 
     594846535 
    chicken
    (Gallus gallus)
    Aves DAPL16
    Uncharacterized protein
    39(a)
    1 ↔ 1
    7(35944238-35948751)
    African clawed frog
    (Xenopus laevis)
    Amphibia CB559023.12   -- 79.95(n)    CB559023.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dap1b6
    dap1b6
    death associated protein 1b
    40(a)
    40(a)
    many → 1
    many → 1
    9(54130194-54133678)
    9(53975568-53979084)


    ENSEMBL Gene Tree for DAPL1 (if available)
    TreeFam Gene Tree for DAPL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DAPL1 gene
    18/63 SIMAP similar genes for DAPL1 using alignment to 9 protein entries:     DAPL1_HUMAN (see all proteins) (see all similar genes):
    FOPNL    OR7E5P    AURA2    DCTN5    UTY    OR1D5
    SHANK2    APOD    TMEM14B    LYRM4    NSRP1    ZNF585B
    DNMT1    FKBP3    LOC441453    OR1F12    OR2J4P    DYM

    DAPL1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DAPL1
    PGOHUM00000234488


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/520 SNPs in DAPL1 are shown (see all 520)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0384034
    ----see VAR_0384032 A T mis40--------
    rs1483274701,2
    C--159649935(+) AGAAGA/GTTTAA 1 -- us2k10--------
    rs1823291841,2
    --159649965(+) CCACCC/TACAGA 1 -- us2k10--------
    rs1862261991,2
    --159649973(+) AGAATA/GCCACT 1 -- us2k10--------
    rs1906345341,2
    --159650224(+) TTTCTA/GTTCCT 1 -- us2k10--------
    rs1828118981,2
    --159650283(+) GTAGCA/TTTTTT 1 -- us2k10--------
    rs109335051,2
    C,F,A,H--159650308(+) ccattA/Taacgt 1 -- us2k127Minor allele frequency- T:0.41NS EA NA CSA WA 2768
    rs45616151,2
    C,F,H--159650386(+) cacaaT/Cctgtt 1 -- us2k119Minor allele frequency- C:0.08NS EA NA WA CSA 2033
    rs744987701,2
    C,F--159650400(+) CCATTC/ATACAG 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1855695961,2
    --159650427(+) TTTCTA/CACTTT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DAPL1 (159651829 - 159719293 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DAPL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676504CNV Deletion23128226
    esv2721022CNV Deletion23290073
    nsv213414CNV Loss16902084
    esv23088CNV Loss19812545
    dgv478n27CNV Gain19166990
    nsv834434CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DAPL1 for disorders           About MalaCards

    DAPL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DAPL1
    Human Genome Epidemiology (HuGE) Navigator: DAPL1 (1 document)

    Export disorders for DAPL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAPL1 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with DAPL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Investigation of genetic susceptibility factors for h uman longevity - A targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (2010)
    2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
    3. EEDA: a protein associated with an early stage of stratified epithelial differentiation. (PubMed id 15920738)2 Sun L.... Lavker R.M. (2006)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    6. Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107413)1 Wistow G.... Peterson K. (2002)
    7. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 92196 HGNC: 21490 AceView: OR7E28P Ensembl:ENSG00000163331 euGenes: HUgn92196
    ECgene: DAPL1 H-InvDB: DAPL1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAPL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DAPL1 gene:
    Search GeneIP for patents involving DAPL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
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     Regulatory tfbs in DAPL1 promoter
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     Search LifeMap BioReagents cell lines for DAPL1
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     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAPL1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DAPL1
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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