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Aliases for DAPL1 Gene

Aliases for DAPL1 Gene

  • Death Associated Protein Like 1 2 3 5
  • Early Epithelial Differentiation-Associated Protein 4
  • Death Associated Protein-Like 1 2
  • EEDA 4

External Ids for DAPL1 Gene

Previous GeneCards Identifiers for DAPL1 Gene

  • GC00U911651
  • GC02U900711
  • GC02P159361
  • GC02P159651
  • GC02P151540

Summaries for DAPL1 Gene

GeneCards Summary for DAPL1 Gene

DAPL1 (Death Associated Protein Like 1) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for DAPL1 Gene

  • May play a role in the early stages of epithelial differentiation or in apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAPL1 Gene

Genomics for DAPL1 Gene

Regulatory Elements for DAPL1 Gene

Enhancers for DAPL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F158795 0.7 Ensembl 9.9 +0.2 184 0.6 PKNOX1 ZNF223 BACH1 MAFG ZNF316 MAFF SCRT2 NFE2L1 NFE2 MYC OR7E28P DAPL1 OR7E89P
GH02F158744 0.9 Ensembl ENCODE 7.7 -49.9 -49878 1.0 CTCF TFAP4 ZNF654 REST ZNF48 RAD21 GATA3 IKZF1 ZNF143 SMC3 OR7E28P DAPL1 GC02M158745 PKP4-AS1
GH02F158772 0.5 Ensembl ENCODE 12.1 -22.6 -22578 1.3 DAPL1 OR7E28P GC02M158745
GH02F158984 0.7 Ensembl 4.9 +189.6 189584 0.6 ZNF263 HLF CEBPB TSHZ1 ATF2 ZFHX2 ATF3 ZNF366 ZNF600 PRDM1 RNU2-21P TANC1 OR7E28P DAPL1 OR7E90P GC02P158993
GH02F158868 0.6 ENCODE 4.4 +73.3 73348 0.9 BCOR SMARCA5 ZNF146 ZNF280D TEAD3 ZNF580 KDM1A ZNF652 OR7E28P DAPL1 OR7E90P
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DAPL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for DAPL1 Gene

158,795,317 bp from pter
158,862,958 bp from pter
67,642 bases
Plus strand

Genomic View for DAPL1 Gene

Genes around DAPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAPL1 Gene

Proteins for DAPL1 Gene

  • Protein details for DAPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Death-associated protein-like 1
    Protein Accession:
    Secondary Accessions:
    • A0PJW9
    • B9EIK6

    Protein attributes for DAPL1 Gene

    107 amino acids
    Molecular mass:
    11880 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DAPL1 Gene

Post-translational modifications for DAPL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAPL1 Gene

No data available for DME Specific Peptides for DAPL1 Gene

Domains & Families for DAPL1 Gene

Protein Domains for DAPL1 Gene


Suggested Antigen Peptide Sequences for DAPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DAPL1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DAPL1 Gene

Function for DAPL1 Gene

Molecular function for DAPL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the early stages of epithelial differentiation or in apoptosis.

Gene Ontology (GO) - Molecular Function for DAPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070513 death domain binding IBA --
genes like me logo Genes that share ontologies with DAPL1: view
genes like me logo Genes that share phenotypes with DAPL1: view

Animal Model Products

miRNA for DAPL1 Gene

miRTarBase miRNAs that target DAPL1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DAPL1 Gene

Localization for DAPL1 Gene

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAPL1 gene
Compartment Confidence
plasma membrane 2
nucleus 2
cytosol 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DAPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DAPL1: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DAPL1 Gene

Pathways & Interactions for DAPL1 Gene

SuperPathways for DAPL1 Gene

No Data Available

Interacting Proteins for DAPL1 Gene

Gene Ontology (GO) - Biological Process for DAPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010507 negative regulation of autophagy IBA --
GO:0030154 cell differentiation IEA --
GO:0034198 cellular response to amino acid starvation IBA --
GO:0097190 apoptotic signaling pathway IBA --
genes like me logo Genes that share ontologies with DAPL1: view

No data available for Pathways by source and SIGNOR curated interactions for DAPL1 Gene

Transcripts for DAPL1 Gene

Unigene Clusters for DAPL1 Gene

Death associated protein-like 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAPL1 Gene

No ASD Table

Relevant External Links for DAPL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DAPL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DAPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAPL1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x14.2), Skin - Not Sun Exposed (Suprapubic) (x11.3), Esophagus - Mucosa (x10.4), and Vagina (x4.4).

Protein differential expression in normal tissues from HIPED for DAPL1 Gene

This gene is overexpressed in Serum (40.6) and Lung (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DAPL1 Gene

Protein tissue co-expression partners for DAPL1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DAPL1 Gene:


SOURCE GeneReport for Unigene cluster for DAPL1 Gene:


mRNA Expression by UniProt/SwissProt for DAPL1 Gene:

Tissue specificity: Expressed in hair follicle (at protein level).
genes like me logo Genes that share expression patterns with DAPL1: view

Primer Products

Orthologs for DAPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DAPL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia DAPL1 34 35
  • 98.75 (n)
(Bos Taurus)
Mammalia DAPL1 34 35
  • 90.34 (n)
(Canis familiaris)
Mammalia DAPL1 34 35
  • 87.85 (n)
(Rattus norvegicus)
Mammalia Dapl1 34
  • 83.49 (n)
(Mus musculus)
Mammalia Dapl1 34 16 35
  • 82.87 (n)
(Ornithorhynchus anatinus)
Mammalia DAPL1 35
  • 66 (a)
(Monodelphis domestica)
Mammalia DAPL1 35
  • 49 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dapl1 34
  • 64.49 (n)
Str.17117 34
Species where no ortholog for DAPL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DAPL1 Gene

Gene Tree for DAPL1 (if available)
Gene Tree for DAPL1 (if available)

Paralogs for DAPL1 Gene

No data available for Paralogs for DAPL1 Gene

Variants for DAPL1 Gene

Sequence variations from dbSNP and Humsavar for DAPL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10016 -- 158,815,930(+) ATTAA(A/G)CAGCT utr-variant-3-prime
rs10169705 -- 158,815,232(+) GACCT(G/T)AAAAA intron-variant
rs10188387 -- 158,808,201(+) GCAGC(C/T)AAAAT intron-variant
rs10203540 -- 158,814,892(+) CAAGA(A/C)CTAGC intron-variant
rs10207833 -- 158,807,179(+) CATGG(A/G)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAPL1 Gene

Variant ID Type Subtype PubMed ID
nsv834434 CNV gain 17160897
nsv583457 CNV loss 21841781
nsv583451 CNV loss 21841781
nsv583450 CNV loss 21841781
nsv583449 CNV gain 21841781
nsv213414 CNV deletion 16902084
nsv1127774 CNV deletion 24896259
nsv1001024 CNV gain 25217958
esv3593087 CNV loss 21293372
esv3593085 CNV gain 21293372
esv3593084 CNV gain 21293372
esv3593083 CNV loss 21293372
esv3584119 CNV loss 25503493
esv3560422 CNV deletion 23714750
esv2721022 CNV deletion 23290073
esv2676504 CNV deletion 23128226
esv23088 CNV loss 19812545
dgv7135n54 CNV loss 21841781
dgv7134n54 CNV loss 21841781
dgv7133n54 CNV loss 21841781
dgv478n27 CNV gain 19166990

Variation tolerance for DAPL1 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAPL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAPL1 Gene

Disorders for DAPL1 Gene

Relevant External Links for DAPL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DAPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DAPL1 Gene

Publications for DAPL1 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 46 64
  2. A Candidate Gene Association Study Identifies DAPL1 as a Female-Specific Susceptibility Locus for Age-Related Macular Degeneration (AMD). (PMID: 25680934) Grassmann F. … Weber B.H. (Neuromolecular Med. 2015) 3 64
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 64
  4. EEDA: a protein associated with an early stage of stratified epithelial differentiation. (PMID: 15920738) Sun L. … Lavker R.M. (J. Cell. Physiol. 2006) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for DAPL1 Gene

Sources for DAPL1 Gene

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