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Aliases for DAPL1 Gene

Aliases for DAPL1 Gene

  • Death Associated Protein Like 1 2 3 5
  • Early Epithelial Differentiation-Associated Protein 4
  • Death Associated Protein-Like 1 2
  • EEDA 4

External Ids for DAPL1 Gene

Previous GeneCards Identifiers for DAPL1 Gene

  • GC00U911651
  • GC02U900711
  • GC02P159361
  • GC02P159651
  • GC02P151540

Summaries for DAPL1 Gene

GeneCards Summary for DAPL1 Gene

DAPL1 (Death Associated Protein Like 1) is a Protein Coding gene. GO annotations related to this gene include G-protein coupled receptor activity.

UniProtKB/Swiss-Prot for DAPL1 Gene

  • May play a role in the early stages of epithelial differentiation or in apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAPL1 Gene

Genomics for DAPL1 Gene

Regulatory Elements for DAPL1 Gene

Genomic Location for DAPL1 Gene

158,795,317 bp from pter
158,862,958 bp from pter
67,642 bases
Plus strand

Genomic View for DAPL1 Gene

Genes around DAPL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAPL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAPL1 Gene

Proteins for DAPL1 Gene

  • Protein details for DAPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Death-associated protein-like 1
    Protein Accession:
    Secondary Accessions:
    • A0PJW9
    • B9EIK6

    Protein attributes for DAPL1 Gene

    107 amino acids
    Molecular mass:
    11880 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DAPL1 Gene

Proteomics data for DAPL1 Gene at MOPED

Post-translational modifications for DAPL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAPL1 Gene

No data available for DME Specific Peptides for DAPL1 Gene

Domains & Families for DAPL1 Gene

Protein Domains for DAPL1 Gene


Suggested Antigen Peptide Sequences for DAPL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DAPL1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DAPL1 Gene

Function for DAPL1 Gene

Molecular function for DAPL1 Gene

UniProtKB/Swiss-Prot Function:
May play a role in the early stages of epithelial differentiation or in apoptosis.
genes like me logo Genes that share phenotypes with DAPL1: view

Animal Model Products

miRNA for DAPL1 Gene

miRTarBase miRNAs that target DAPL1

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DAPL1 Gene

Localization for DAPL1 Gene

Subcellular locations from

Jensen Localization Image for DAPL1 Gene COMPARTMENTS Subcellular localization image for DAPL1 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
extracellular 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DAPL1 Gene

Pathways & Interactions for DAPL1 Gene

SuperPathways for DAPL1 Gene

No Data Available

Interacting Proteins for DAPL1 Gene

Gene Ontology (GO) - Biological Process for DAPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007186 G-protein coupled receptor signaling pathway IEA --
GO:0010507 negative regulation of autophagy IBA --
GO:0097190 apoptotic signaling pathway IBA --
genes like me logo Genes that share ontologies with DAPL1: view

No data available for Pathways by source and SIGNOR curated interactions for DAPL1 Gene

Drugs & Compounds for DAPL1 Gene

No Compound Related Data Available

Transcripts for DAPL1 Gene

Unigene Clusters for DAPL1 Gene

Death associated protein-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DAPL1 Gene

No ASD Table

Relevant External Links for DAPL1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DAPL1 Gene

mRNA expression in normal human tissues for DAPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAPL1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (x14.2), Skin - Not Sun Exposed (Suprapubic) (x11.3), Esophagus - Mucosa (x10.4), and Vagina (x4.4).

Protein differential expression in normal tissues from HIPED for DAPL1 Gene

This gene is overexpressed in Serum (40.6) and Lung (20.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DAPL1 Gene

SOURCE GeneReport for Unigene cluster for DAPL1 Gene Hs.59761

mRNA Expression by UniProt/SwissProt for DAPL1 Gene

Tissue specificity: Expressed in hair follicle (at protein level).
genes like me logo Genes that share expression patterns with DAPL1: view

Protein tissue co-expression partners for DAPL1 Gene

Primer Products

In Situ Assay Products

Orthologs for DAPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DAPL1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DAPL1 35
  • 90.34 (n)
  • 85.05 (a)
DAPL1 36
  • 86 (a)
(Canis familiaris)
Mammalia DAPL1 35
  • 87.85 (n)
  • 80.37 (a)
DAPL1 36
  • 80 (a)
(Mus musculus)
Mammalia Dapl1 35
  • 82.87 (n)
  • 81.31 (a)
Dapl1 16
Dapl1 36
  • 81 (a)
(Pan troglodytes)
Mammalia DAPL1 35
  • 98.75 (n)
  • 98.13 (a)
DAPL1 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Dapl1 35
  • 83.49 (n)
  • 81.31 (a)
(Monodelphis domestica)
Mammalia DAPL1 36
  • 49 (a)
(Ornithorhynchus anatinus)
Mammalia DAPL1 36
  • 66 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dapl1 35
  • 64.49 (n)
  • 52.34 (a)
Str.17117 35
Species with no ortholog for DAPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DAPL1 Gene

Gene Tree for DAPL1 (if available)
Gene Tree for DAPL1 (if available)

Paralogs for DAPL1 Gene Pseudogenes for DAPL1 Gene

genes like me logo Genes that share paralogs with DAPL1: view

No data available for Paralogs for DAPL1 Gene

Variants for DAPL1 Gene

Sequence variations from dbSNP and Humsavar for DAPL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs9869 - 158,807,087(-) CATCC(A/G)GTGTC reference, missense
VAR_038403 -
rs10016 -- 158,815,930(+) ATTAA(A/G)CAGCT intron-variant, utr-variant-3-prime
rs12535 -- 158,807,104(-) CAGTG(A/C/T)GTCAT reference, missense
rs925780 -- 158,798,591(-) CGTTC(A/G)CTCTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAPL1 Gene

Variant ID Type Subtype PubMed ID
nsv834434 CNV Gain 17160897
dgv478n27 CNV Gain 19166990
esv23088 CNV Loss 19812545
esv2721022 CNV Deletion 23290073
esv2676504 CNV Deletion 23128226
nsv213414 CNV Loss 16902084

Variation tolerance for DAPL1 Gene

Residual Variation Intolerance Score: 82.4% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAPL1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAPL1 Gene

Disorders for DAPL1 Gene

Relevant External Links for DAPL1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for DAPL1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DAPL1 Gene

Publications for DAPL1 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 48 67
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  3. Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107413) Wistow G. … Peterson K. (Mol. Vis. 2002) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for DAPL1 Gene

Sources for DAPL1 Gene

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