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DAPL1 Gene

protein-coding GIFtS: 37

GC02P159361

death associated protein-like 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
EEDA ^³

Descriptions
Early epithelial differentiation-associated protein ^³
death associated protein-like 1 ^²

External Ids
HGNC: 21490¹
Entrez Gene: 92196²
UniProtKB: A0PJW8³
Ensembl: ENSG00000163331⁷

Search outside databases for aliases for DAPL1 gene

Previous GC identifers: GC00U911651 GC02U900711

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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UniProtKB/Swiss-Prot: DAPL1_HUMAN, A0PJW8

Function: May play a role in the early stages of epithelial differentiation or in apoptosis (By

similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q24.1 Ensembl cytogenetic band: 2q24.1 HGNC cytogenetic band: 2q24

DAPL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P159361: (about GC identifiers)

Start:	159,360,075 bp from pter
End:	159,418,540 bp from pter
Size:	58,466 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DAPL1_HUMAN, A0PJW8 (See protein sequence)

Recommended Name: Death-associated protein-like 1

Size: 107 amino acids; 11880 Da

Secondary accessions: A0PJW9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001017920.2

ENSEMBL proteins:

ENSP00000386422 ENSP00000309538

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
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	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse Abcam for Recombinant Proteins
	Browse Abnova for Human Recombinant Proteins

OriGene Purified Recombinant Human Protein: DAPL1

Antibodies for DAPL1:

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	Search Novus for antibodies for DAPL1

Assays for DAPL1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: A0PJW8

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAPL1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001017920

Applied Biosystems Silencer® siRNAs for DAPL1

Sigma-Aldrich siRNA for DAPL1

Sigma-Aldrich shRNA for DAPL1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001017920
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001017920
untagged cDNA clone in CMV expression vector: NM_001017920

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001017920

UniProtKB/Swiss-Prot: DAPL1_HUMAN, A0PJW8

Function: May play a role in the early stages of epithelial differentiation or in apoptosis (By

similarity)

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptosis	IEA	--
GO:0030154	cell differentiation	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DAPL1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAPL1)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_001017920

Sigma-Aldrich siRNA for DAPL1

Sigma-Aldrich shRNA for DAPL1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001017920

REFSEQ mRNAs for DAPL1 gene:

NM_001017920.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001017920

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001017920
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001017920
                                 untagged cDNA clone in CMV expression vector: NM_001017920

Additional cDNA sequence:

AF086541.1 AY324399.1 BC127682.1 BC127683.1 BC140719.1

1 DOTS entry:

DT.212081

24/37 AceView cDNA sequences (see all 37 ):

AA365503 AA365801 C00396 AA453779 AA453863 BM129664 AA442475 BX117859

BG818506 CD675155 AI692575 BQ189090 CK299997 AA975337 BQ185417 AI632902

AA365504 AW131631 AA732993 AF086541 AA988869 BM129377 W96131 BM128924

Unigene Cluster for DAPL1:

Death associated protein-like 1

Hs.59761 [show with all ESTs]

Unigene Representative Sequence: EL950760

GeneLoc Exon Structure

2 Ensembl transcripts including schematic representations:

ENST00000409042 ENST00000309950

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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DAPL1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DAPL1

¹ / ²

3 probe-sets matching DAPL1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
46163_at²	U95-B	2	1.00	0.91	1.00	1.00	--	--	--	--	--
229290_at²	U133-B	2	1.00	0.95	--	--	--	--	--	--	--
229290_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCGCATCAAA

SOURCE GeneReport for Unigene cluster: Hs.59761
UniProtKB/Swiss-Prot: DAPL1_HUMAN, A0PJW8
Tissue specificity: Expressed in hair follicle (at protein level)

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DAPL1 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DAPL1¹	--	death associated protein-like 1	88.47(n) 81.31(a)	607792 XM_844590.1 XP_849683.1
chimpanzee (Pan troglodytes)	DAPL1¹	--	death associated protein-like 1	98.13(n) 97.2(a)	738215 XM_001147594.1 XP_001147594.1
cow (Bos taurus)	DAPL1¹	--	death associated protein-like 1	90.97(n) 85.98(a)	574085 NM_001025346.1 NP_001020517.1
rat (Rattus norvegicus)	Dapl1¹	--	death associated protein-like 1	84.11(n) 82.24(a)	362136 XM_342436.2 XP_342437.1
mouse (Mus musculus)	Dapl1^{1, 5}	2⁵	death associated protein-like 1^{1, 5}	83.18(n)¹ 82.24(a)¹	76747¹ NM_029723.2¹ NP_083999.1¹ AK009567⁵ AK133382⁵ (see all 11)

About this table Species with no ortholog for DAPL1

ENSEMBL Gene Tree for DAPL1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/140 NCBI SNPs in DAPL1 are shown (see all 140 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 78)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs10016^1,2	A,C,F,H,O	159380688(+)	`ATTAAG/ACAGCT`	1	--	ut3¹ ese³		14		EA MN NA EU WA	2674
	rs9869^1,2	A,C,F,H,O	159371845(-)	`CATCCG/AGTGTC`	1	P/L	mis¹ ese³		22		EA NS NA EU WA	3008
	rs10933505^1,2	A,C,F,H	159358554(+)	`ccattA/Taacgt`	1	--	ng5¹		8		EU EA WA	810
	rs4561615^1,2	C,F,H	159358632(+)	`cacaaT/Cctgtt`	1	--	ng5¹		7		EU EA WA NA	558
	rs11673825^1,2	C,F,H	159380872(+)	`AGCACT/CCTTCT`	1	--	ng3¹		11		NA EU EA WA	976
	rs925781^1,2	C,F,H	159359980(-)	`CTCTCC/TGGGAA`	1	--	ng5¹		15		EU EA WA NA	2940
	rs13401347^1,2	C,F,H	159359101(+)	`tgtctG/Actttc`	1	--	ng5¹ tfbs³		3		EU EA	272
	rs10497199^1,2	C,F,H	159371862(+)	`ATGACG/ACACTG`	1	T/A	mis¹ ese³		16		NS EU EA WA NA	1080
--	rs2356509^1,2	A,C	159358929(+)	`tttttC/Tttgtc`	1	--	ng5¹ trp³		0	--	--	--	--
	rs17810398^1,2	F,H	159369116(+)	`GGATTC/TGAGAA`	1	F/F	syn¹ ese³		7		NA EU EA WA	542

About this table

HapMap Linkage Disequilibrium images for DAPL1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

5 PubMed articles for DAPL1 gene:

EEDA: a protein associated with an early stage of stratified epithelial differentiation. (PubMed id 15920738)⁴ Sun L.... Lavker R.M. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)⁴ Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)
Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PubMed id 12107413)³ Wistow G.... Peterson K. (2002)
Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )⁴ Aoki H.... Hino O. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 92196	HGNC: 21490	AceView: OR7E28P	Ensembl:ENSG00000163331	euGenes: HUgn92196
ECgene: DAPL1	H-InvDB: DAPL1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Licensable Technologies for DAPL1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for DAPL1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DAPL1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DAPL1		Browse antibodies at Sigma-Aldrich
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	Lentivirus-delivered shRNAs for DAPL1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	shRNA in GFP-retroviral vector

Search Tocris compounds for DAPL1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

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DAPL1 Gene

protein-coding GIFtS: 37

Aliases &
Descriptions
for DAPL1

Summaries
for DAPL1

Genomic Location
for DAPL1

Proteins
for DAPL1

Protein Domains/
Families
for DAPL1

Gene Function
for DAPL1

Pathways & Interactions
for DAPL1

Drugs & Compounds
for DAPL1

Transcripts
for DAPL1

Expression
for DAPL1

Orthologs
for DAPL1

Paralogs
for DAPL1

SNPs/Variants
for DAPL1

Disorders & Mutations
for DAPL1

Medical News
for DAPL1

Publications
for DAPL1

Search for DAPL1

Genome Databases showing DAPL1

Other Databases showing DAPL1

Specialized Databases showing DAPL1

Licensable Technologies
for DAPL1

Services
for DAPL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DAPL1 Gene

protein-coding GIFtS: 37

Aliases & Descriptionsfor DAPL1

Summariesfor DAPL1

Genomic Locationfor DAPL1

Proteinsfor DAPL1

Protein Domains/Familiesfor DAPL1

Gene Functionfor DAPL1

Pathways & Interactionsfor DAPL1

Drugs & Compoundsfor DAPL1

Transcriptsfor DAPL1

Expression for DAPL1

Orthologsfor DAPL1

Paralogsfor DAPL1

SNPs/Variantsfor DAPL1

Disorders & Mutationsfor DAPL1

Medical Newsfor DAPL1

Publicationsfor DAPL1

Search for DAPL1

Genome Databases showing DAPL1

Other Databases showing DAPL1

Specialized Databases showing DAPL1

Licensable Technologiesfor DAPL1

Servicesfor DAPL1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DAPL1

Summaries
for DAPL1

Genomic Location
for DAPL1

Proteins
for DAPL1

Protein Domains/
Families
for DAPL1

Gene Function
for DAPL1

Pathways & Interactions
for DAPL1

Drugs & Compounds
for DAPL1

Transcripts
for DAPL1

Expression
for DAPL1

Orthologs
for DAPL1

Paralogs
for DAPL1

SNPs/Variants
for DAPL1

Disorders & Mutations
for DAPL1

Medical News
for DAPL1

Publications
for DAPL1

Licensable Technologies
for DAPL1

Services
for DAPL1