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Aliases for DAPL1 Gene

Aliases for DAPL1 Gene

  • Death Associated Protein-Like 1 2 3
  • Early Epithelial Differentiation-Associated Protein 4
  • EEDA 4

External Ids for DAPL1 Gene

Summaries for DAPL1 Gene

GeneCards Summary for DAPL1 Gene

DAPL1 (Death Associated Protein-Like 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for DAPL1 Gene

  • May play a role in the early stages of epithelial differentiation or in apoptosis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAPL1 Gene

Genomics for DAPL1 Gene

Genomic Location for DAPL1 Gene

Start:
158,795,317 bp from pter
End:
158,862,958 bp from pter
Size:
67,642 bases
Orientation:
Plus strand

Genomic View for DAPL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAPL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAPL1 Gene

Regulatory Elements for DAPL1 Gene

Proteins for DAPL1 Gene

  • Protein details for DAPL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A0PJW8-DAPL1_HUMAN
    Recommended name:
    Death-associated protein-like 1
    Protein Accession:
    A0PJW8
    Secondary Accessions:
    • A0PJW9
    • B9EIK6

    Protein attributes for DAPL1 Gene

    Size:
    107 amino acids
    Molecular mass:
    11880 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DAPL1 Gene

Proteomics data for DAPL1 Gene at MOPED

Post-translational modifications for DAPL1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAPL1 Gene

No data available for DME Specific Peptides for DAPL1 Gene

Domains for DAPL1 Gene

Protein Domains for DAPL1 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with DAPL1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DAPL1 Gene

Function for DAPL1 Gene

Molecular function for DAPL1 Gene

UniProtKB/Swiss-Prot Function: May play a role in the early stages of epithelial differentiation or in apoptosis.

Gene Ontology (GO) - Molecular Function for DAPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004930 G-protein coupled receptor activity --
genes like me logo Genes that share ontologies with DAPL1: view

Phenotypes for DAPL1 Gene

GenomeRNAi human phenotypes for DAPL1:
genes like me logo Genes that share phenotypes with DAPL1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DAPL1 Gene

Localization for DAPL1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAPL1 Gene COMPARTMENTS Subcellular localization image for DAPL1 gene
Compartment Confidence
cytosol 2
nucleus 2
plasma membrane 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DAPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane --
genes like me logo Genes that share ontologies with DAPL1: view

Pathways for DAPL1 Gene

SuperPathways for DAPL1 Gene

No Data Available

Interacting Proteins for DAPL1 Gene

Gene Ontology (GO) - Biological Process for DAPL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process IEA --
GO:0007186 G-protein coupled receptor signaling pathway --
GO:0030154 cell differentiation IEA --
genes like me logo Genes that share ontologies with DAPL1: view

No data available for Pathways by source for DAPL1 Gene

Transcripts for DAPL1 Gene

Unigene Clusters for DAPL1 Gene

Death associated protein-like 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DAPL1 Gene

No ASD Table

Relevant External Links for DAPL1 Gene

GeneLoc Exon Structure for
DAPL1
ECgene alternative splicing isoforms for
DAPL1

Expression for DAPL1 Gene

mRNA expression in normal human tissues for DAPL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAPL1 Gene

This gene is overexpressed in Skin - Sun Exposed (Lower leg) (14.2), Skin - Not Sun Exposed (Suprapubic) (11.3), Esophagus - Mucosa (10.4), and Vagina (4.4).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for DAPL1 Gene

SOURCE GeneReport for Unigene cluster for DAPL1 Gene Hs.59761

mRNA Expression by UniProt/SwissProt for DAPL1 Gene

A0PJW8-DAPL1_HUMAN
Tissue specificity: Expressed in hair follicle (at protein level).
genes like me logo Genes that share expressions with DAPL1: view

Orthologs for DAPL1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DAPL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAPL1 36
  • 98.75 (n)
  • 98.13 (a)
DAPL1 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DAPL1 36
  • 90.34 (n)
  • 85.05 (a)
DAPL1 37
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAPL1 36
  • 87.85 (n)
  • 80.37 (a)
DAPL1 37
  • 80 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dapl1 36
  • 82.87 (n)
  • 81.31 (a)
Dapl1 16
Dapl1 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DAPL1 37
  • 49 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAPL1 37
  • 66 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dapl1 36
  • 83.49 (n)
  • 81.31 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dapl1 36
  • 64.49 (n)
  • 52.34 (a)
Str.17117 36
Species with no ortholog for DAPL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DAPL1 Gene

ENSEMBL:
Gene Tree for DAPL1 (if available)
TreeFam:
Gene Tree for DAPL1 (if available)

Paralogs for DAPL1 Gene

Pseudogenes.org Pseudogenes for DAPL1 Gene

genes like me logo Genes that share paralogs with DAPL1: view

No data available for Paralogs for DAPL1 Gene

Variants for DAPL1 Gene

Sequence variations from dbSNP and Humsavar for DAPL1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9869 - 158,807,087(-) CATCC(A/G)GTGTC missense, reference
rs10016 -- 158,815,930(+) ATTAA(A/G)CAGCT utr-variant-3-prime
rs12535 -- 158,807,104(-) CAGTG(C/T)GTCAT missense, reference
rs908402 -- 158,811,219(-) CTCCC(C/T)CAGGA intron-variant
rs908403 -- 158,810,785(-) ATGTC(A/T)TGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAPL1 Gene

Variant ID Type Subtype PubMed ID
nsv834434 CNV Gain 17160897
dgv478n27 CNV Gain 19166990
esv23088 CNV Loss 19812545
esv2721022 CNV Deletion 23290073
esv2676504 CNV Deletion 23128226
nsv213414 CNV Loss 16902084

Relevant External Links for DAPL1 Gene

HapMap Linkage Disequilibrium report
DAPL1

Disorders for DAPL1 Gene

Relevant External Links for DAPL1

Genetic Association Database (GAD)
DAPL1
Human Genome Epidemiology (HuGE) Navigator
DAPL1
genes like me logo Genes that share disorders with DAPL1: view

No data available for UniProtKB/Swiss-Prot for DAPL1 Gene

Publications for DAPL1 Gene

  1. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PMID: 20800603) Flachsbart F. … Nebel A. (Mutat. Res. 2010) 3 49
  2. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. EEDA: a protein associated with an early stage of stratified epithelial differentiation. (PMID: 15920738) Sun L. … Lavker R.M. (J. Cell. Physiol. 2006) 4
  5. Expressed sequence tag analysis of adult human lens for the NEIBank project: over 2000 non-redundant transcripts, novel genes and splice variants. (PMID: 12107413) Wistow G. … Peterson K. (Mol. Vis. 2002) 3

Products for DAPL1 Gene

Sources for DAPL1 Gene

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