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DAPK3 Gene

protein-coding   GIFtS: 68
GCID: GC19M003958

Death-Associated Protein Kinase 3

  See DAPK3-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Death-Associated Protein Kinase 31 2     EC 2.7.11.13 8
ZIPK2 3 5     ZIP2
Zipper-Interacting Protein Kinase2 3     dlk2
ZIP-kinase2 3     ZIP Kinase Isoform2
DAP Kinase 32 3     Dlk3
DAP-Like Kinase2 3     EC 2.7.118
MYPT1 Kinase2 3     

External Ids:    HGNC: 26761   Entrez Gene: 16132   Ensembl: ENSG000001676577   OMIM: 6032895   UniProtKB: O432933   

Export aliases for DAPK3 gene to outside databases

Previous GC identifers: GC19M004050 GC19M003898 GC19M003909 GC19M003721


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAPK3 Gene:
Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in
mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. (provided by
RefSeq, Jul 2008)

GeneCards Summary for DAPK3 Gene:
DAPK3 (death-associated protein kinase 3) is a protein-coding gene. Diseases associated with DAPK3 include recessive dystrophic epidermolysis bullosa. GO annotations related to this gene include protein serine/threonine kinase activity and protein homodimerization activity. An important paralog of this gene is STK17B.

UniProtKB/Swiss-Prot: DAPK3_HUMAN, O43293
Function: Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription,
translation, actin cytoskeleton reorganization, cell motility, smooth muscle contraction, and mitosis,
particularly cytokinesis. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on
the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is
characterized by the accumulation of autophagic vesicles. Regulates myosin phosphorylation in both smooth muscle
and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or
through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A, and the
inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state.
Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates
STAT3 and enhances its transcriptional activity. Positively regulates the canonical Wnt/beta-catenin signaling
through interaction with NLK and TCF7L2. Can disrupt the NLK-TCF7L2 complex thereby influencing the
phosphorylation of TCF7L2 by NLK. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Involved
in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the
eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection. Phosphorylates RPL13A on
'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, its association with
the GAIT complex and its subsequent involvement in transcript-selective translation inhibition
Function: Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B

Gene Wiki entry for DAPK3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011295.12  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAPK3 gene promoter:
         Sp1   p53   NRSF form 1   c-Myb   STAT3   STAT5A   NRSF form 2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DAPK3 promoter sequence
   Search Chromatin IP Primers for DAPK3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAPK3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

DAPK3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAPK3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M003958:  view genomic region     (about GC identifiers)

Start:
3,958,451 bp from pter      End:
3,971,121 bp from pter
Size:
12,671 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DAPK3_HUMAN, O43293 (See protein sequence)
Recommended Name: Death-associated protein kinase 3  
Size: 454 amino acids; 52536 Da
Cofactor: Magnesium
Subunit: Monomer and homotrimer. Can also exist as homodimer or form heterodimers with ATF4. Homodimerization is
required for activation segment autophosphorylation Both interactions require an intact leucine zipper domain and
oligomerization is required for full enzymatic activity. Also binds to DAXX and PAWR, possibly in a ternary
complex which plays a role in caspase activation. According to PubMed:17953487, does not interact with PARW.
Interacts with AATF, CDC5L, UBE2D1, UBE2D2 AND UBE2D3. Interacts with AR and this interaction is enhanced by
AATF. Interacts (via leucine zipper) with TCP10L (via leucine zipper). Interacts (via kinase domain) with DAPK1
(via kinase domain). Interacts with STAT3, NLK and TCF7L2. Isoform 1 and isoform 2 can interact with myosin and
PPP1R12A
Miscellaneous: The murine DAPK3 protein differs from the human ortholog, losing an important phosphorylation site
and displaying distinct altered cellular localization. The murine protein localizes only to the nucleus while the
human protein shows both nuclear and cytoplasmic localization. A different protein interaction capacity, with an
important protein partner in the apoptosis pathway (PAWR), evolved in the murine system to maintain the basic
membrane blebbing function in the apoptosis pathway
4 PDB 3D structures from and Proteopedia for DAPK3:
1YRP (3D)        2J90 (3D)        3BHY (3D)        3BQR (3D)    
Secondary accessions: A0AVN4 B3KQE2 Q05JY4
Alternative splicing: 2 isoforms:  O43293-1   O43293-2   (The internal splice site between exon 8 and the 3' UTR, which yields this truncated isoform, is non-canonical)

Explore the universe of human proteins at neXtProt for DAPK3: NX_O43293

Explore proteomics data for DAPK3 at MOPED

Post-translational modifications: 

  • Ubiquitinated. Ubiquitination mediated by the UBE2D3 E3 ligase does not lead to proteasomal degradation, but
    influences promyelocytic leukemia protein nuclear bodies (PML-NBs) formation in the nucleus1
  • The phosphorylation status is critical for: its intracellular localization, ability to oligomerize and its
    activity. The phosphorylated form is anchored in the cytoplasm and/or prevented from being shuttled to the
    nucleus, whereas nuclear translocation or retention is maximal when it is not phosphorylated. Phosphorylation
    increases the trimeric form, and its dephosphorylation shifts the equilibrium towards the monomeric form.
    Phosphorylation at Thr-180, Thr-225 and Thr-265 is essential for activity. Phosphorylation at Thr-299 promotes
    cytoplasmic localization. A species-specific loss of a key phosphorylation site in murine DAPK3 seems to direct
    it to the nucleus, while the presence of the Thr-299 site in human DAPK3 correlates with cytoplasmic
    localization. Both isoform 1 and isoform 2 can undergo autophosphorylation1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DAPK3 (O43293) (see all 9)
     IRRLLVKD  GVITYILL  GTPEFVAPE  TSELAKDFIR 


    See DAPK3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001339.1  
    ENSEMBL proteins: 
     ENSP00000442973   ENSP00000470168   ENSP00000471154   ENSP00000472988   ENSP00000470115  
     ENSP00000301264  
    Reactome Protein details: O43293

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: death-associated protein kinase 3
    Death-associated kinase (DAPK) family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry O43293

    ProtoNet protein and cluster: O43293

    UniProtKB/Swiss-Prot: DAPK3_HUMAN, O43293
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    Find genes that share domains with DAPK3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAPK3_HUMAN, O43293
    Function: Serine/threonine kinase which is involved in the regulation of apoptosis, autophagy, transcription,
    translation, actin cytoskeleton reorganization, cell motility, smooth muscle contraction, and mitosis,
    particularly cytokinesis. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on
    the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is
    characterized by the accumulation of autophagic vesicles. Regulates myosin phosphorylation in both smooth muscle
    and non-muscle cells. In smooth muscle, regulates myosin either directly by phosphorylating MYL12B and MYL9 or
    through inhibition of smooth muscle myosin phosphatase (SMPP1M) via phosphorylation of PPP1R12A, and the
    inhibition of SMPP1M functions to enhance muscle responsiveness to Ca(2+) and promote a contractile state.
    Enhances transcription from AR-responsive promoters in a hormone- and kinase-dependent manner. Phosphorylates
    STAT3 and enhances its transcriptional activity. Positively regulates the canonical Wnt/beta-catenin signaling
    through interaction with NLK and TCF7L2. Can disrupt the NLK-TCF7L2 complex thereby influencing the
    phosphorylation of TCF7L2 by NLK. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosis. Involved
    in the formation of promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear domains in the
    eukaryotic cell nucleus, and which is involved in oncogenesis and viral infection. Phosphorylates RPL13A on
    'Ser-77' upon interferon-gamma activation which is causing RPL13A release from the ribosome, its association with
    the GAIT complex and its subsequent involvement in transcript-selective translation inhibition
    Function: Isoform 2 can phosphorylate myosin, PPP1R12A and MYL12B
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Inhibited by pyridone 6 (K00225), a potent, ATP-competitive inhibitor. Phosphorylation at
    Thr-180, Thr-225 and Thr-265 is essential for activity. Oligomerization is required for full enzymatic activity
    Biophysicochemical properties: Kinetic parameters: KM=12 uM for myosin (isoform 2); KM=6.2 uM for myosin (isoform
    1); KM=73 uM for MYL12B (isoform 2); KM=10.4 uM for MYL12B (isoform 1); Vmax=248 nmol/min/mg enzyme toward myosin
    (isoform 2); Vmax=120 nmol/min/mg enzyme toward myosin (isoform 1); Vmax=1.3 umol/min/mg enzyme toward MYL12B
    (isoform 2); Vmax=271 nmol/min/mg enzyme toward MYL12B (isoform 1);

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS16756490
    GO:0004683calmodulin-dependent protein kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
         
    Find genes that share ontologies with DAPK3           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DAPK3:
     Decreased focal adhesion (FA)   Decreased substrate adherent c 

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DAPK3

    miRNA
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    miRTarBase miRNAs that target DAPK3:
    hsa-mir-17-5p (MIRT051054), hsa-mir-93-5p (MIRT048888)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DAPK3_HUMAN, O43293: Nucleus. Cytoplasm. Nucleus, PML body. Chromosome, centromere. Cytoplasm, cytoskeleton,
    microtubule organizing center, centrosome. Note=The phosphorylated form is anchored in the cytoplasm and/or
    prevented from being shuttled to the nucleus, whereas nuclear translocation or retention is maximal when it is
    not phosphorylated. Phosphorylation at Thr-299 promotes cytoplasmic localization. Relocates to the cytoplasm on
    binding PAWR where the complex appears to interact with actin filaments. Localizes to promyelocytic leukemia
    protein nuclear bodies (PML-NBs). Associated: with the centrosomes throughout the mitotic cell cycle, with the
    centromeres from prophase to anaphase and with the contractile ring during cytokinesis
    DAPK3_HUMAN, O43293: Isoform 2: Nucleus. Cytoplasm
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    cytosol3

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000775chromosome, centromeric region IEA--
    GO:0005634nucleus ISS--
    GO:0005737cytoplasm IEA--
    GO:0005815microtubule organizing center IEA--
    GO:0016020membrane ----

    Find genes that share ontologies with DAPK3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAPK3 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of Apoptosis0.82
    Role of DCC in regulating apoptosis0.00
    Apoptosis0.38
    2Apoptotic Pathways in Synovial Fibroblasts
    Cellular Apoptosis Pathway0.85
    3TNF Signaling
    Death Receptor Signaling0.50
    4Glioma
    Bladder cancer0.31
    5Pathways in cancer
    Pathways in cancer


    Find genes that share SuperPaths with DAPK3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DAPK3
        Cellular Apoptosis Pathway

    1 Cell Signaling Technology (CST) Pathway for DAPK3
        Apoptosis and Autophagy

    1 Sino Biological Pathway for DAPK3
        Death Receptor Signaling

    1 Reactome Pathway for DAPK3
        Role of DCC in regulating apoptosis


    2 Kegg Pathways  (Kegg details for DAPK3):
        Pathways in cancer
    Bladder cancer

        Pathway & Disease-focused RT2 Profiler PCR Array including DAPK3: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DAPK3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DAPK3 (O432931, 3 ENSP000003012644) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DAXXQ9UER73, ENSP000003968764I2D: score=3 STRING: ENSP00000396876 STRING: ENSP00000266000
    ENSG00000206206Q9UER73I2D: score=3 
    ENSG00000206279Q9UER73I2D: score=3 
    ENSG00000227046Q9UER73I2D: score=3 
    ENSG00000231617Q9UER73I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 21):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis TAS--
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated TAS--
    GO:0006468protein phosphorylation IDA10356987
    GO:0006915apoptotic process IMP12917339

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    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAPK3

    3 HMDB Compounds for DAPK3    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    MagnesiumMagnesium (see all 2)7439-95-4--

    3 DrugBank Compounds for DAPK3    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    (4R)-7,8-dichloro-1',9-dimethyl-1-oxo-1,2,4,9-tetrahydrospiro[beta-carboline-3,4'-piperidine]-4-carbonitrile-- --target--10592235
    2-(1,1-DIMETHYLETHYL)9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLIN-7-ONE-- --target--10592235
    4-(6-{[(1R)-1-(hydroxymethyl)propyl]amino}imidazo[1,2-b]pyridazin-3-yl)benzoic acid-- --target--10592235

    3 Novoseek inferred chemical compound relationships for DAPK3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 64.4 13 9840928 (3), 9488481 (2), 10602474 (1), 11781833 (1) (see all 8)
    leucine 55.8 8 9488481 (3), 17126281 (2), 10602474 (1), 15207272 (1)
    serine 53.1 15 9840928 (3), 9488481 (2), 10602474 (1), 11781833 (1) (see all 9)



    Find genes that share compounds with DAPK3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DAPK3 gene: 
    NM_001348.1  

    Unigene Cluster for DAPK3:

    Death-associated protein kinase 3
    Hs.631844  [show with all ESTs]
    Unigene Representative Sequence: AK027590
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000545797(uc002lzd.1) ENST00000595279 ENST00000594894 ENST00000596311
    ENST00000601824 ENST00000593844 ENST00000301264(uc002lzb.1 uc002lzc.1)

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    Additional mRNA sequence: 

    AB007144.1 AB022341.1 AB265224.1 AK027590.1 AK074799.1 AK093792.1 AK097643.1 BC126430.1 
    BC126432.1 

    9 DOTS entries:

    DT.115342  DT.100780033  DT.100780036  DT.95270568  DT.121442910  DT.91763801  DT.95270565  DT.40228801 
    DT.95209019 

    Selected AceView cDNA sequences (see all 179):

    BM929559 AK097643 AI654829 AI468095 BF976537 AI566563 H50048 AI207294 
    CD676336 AI470975 BQ071271 AB022341 BM763093 BM980897 AI652896 AI990401 
    AW575746 AI198870 BM716829 BM930593 CD671566 AI499679 BM701458 BM931208 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for DAPK3    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9a · 9b
    SP1:                    -                                   -                           
    SP2:              -     -                                                               
    SP3:                                                                                    
    SP4:                                                                                    


    ECgene alternative splicing isoforms for DAPK3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAPK3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAGCATCG
    DAPK3 Expression
    About this image

    DAPK3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAPK3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.631844

    UniProtKB/Swiss-Prot: DAPK3_HUMAN, O43293
    Tissue specificity: Isoform 2 is expressed in the bladder smooth muscle

        Pathway & Disease-focused RT2 Profiler PCR Array including DAPK3: 
              Apoptosis 384HT in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DAPK3 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dapk31 , 5 death-associated protein kinase 31, 5 82.22(n)1
    85.04(a)1
      10 (39.72 cM)5
    131441  NM_001190474.11  NP_001177403.21 
     811830075 
    chicken
    (Gallus gallus)
    Aves DAPK31 death-associated protein kinase 3 81.94(n)
    83.8(a)
      101748881  XM_004948763.1  XP_004948820.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia BU906015.12   -- 77.43(n)    BU906015.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dapk31 death-associated protein kinase 3 74.92(n)
    82.21(a)
      562194  XM_685593.5  XP_690685.1 
    worm
    (Caenorhabditis elegans)
    Secernentea dapk-16
    Protein DAPK-1 (dapk-1) mRNA, complete cds
    12(a)
    1 → many
    I(1305575-1328228) WBGene00003400
    rice
    (Oryza sativa)
    Liliopsida NM_191016.12   -- 75.04(n)    NM_191016.1 


    ENSEMBL Gene Tree for DAPK3 (if available)
    TreeFam Gene Tree for DAPK3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAPK3 gene
    STK17B2  DAPK22  MYLK22  TTN2  STK17A2  MYLK32  OBSCN2  SPEG2  
    MYLK42  DAPK12  MYLK2  
    Selected SIMAP similar genes for DAPK3 using alignment to 4 protein entries:     DAPK3_HUMAN (see all proteins) (see all similar genes):
    DAPK1    DAPK2    BRSK2    STK17A    STK17B    KALRN
    BRSK1    HUNK    MYLK    MYLK3    RPS6KA4    MYLK4
    PHKG2    CAMK1    MARK4    PRKAA1    STK36    TTN

    Find genes that share paralogs with DAPK3           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAPK3 (see all 370)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0404384
    A colorectal adenocarcinoma sample4--see VAR_0404382 T M mis40--------
    VAR_0404404
    A lung neuroendocrine carcinoma sample4--see VAR_0404402 P S mis40--------
    VAR_0404394
    An ovarian mucinous carcinoma sample4--see VAR_0404392 D N mis40--------
    rs1440894431,2
    --3721245(+) AAAAA-/GCAAAAA 1 -- ds50010--------
    rs1927867321,2
    --3721276(+) GGACAA/GGGTCG 1 -- ds50010--------
    rs1171170781,2
    F--3721403(+) CATCCC/AGTAAG 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs1436614611,2
    --3721427(+) GGAAAC/TGCTTC 1 -- ds50010--------
    rs37459801,2
    C,F,A,H--3721553(+) TTTGTG/CCCCTC 1 -- ds500114Minor allele frequency- C:0.38EA NS NA WA CSA 1942
    rs1855201311,2
    --3721589(+) GAACAC/GAGAGA 1 -- ds50010--------
    rs72551231,2
    C,F,A,H--3721626(+) TCCCCG/AGTGGC 1 -- ds500122Minor allele frequency- A:0.19NS EA NA WA CSA 2352

    HapMap Linkage Disequilibrium report for DAPK3 (3958451 - 3971121 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for DAPK3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv910791CNV Loss21882294
    dgv3665n71CNV Loss21882294
    nsv910786CNV Loss21882294
    nsv910783CNV Loss21882294
    nsv910780CNV Loss21882294
    dgv3666n71CNV Loss21882294
    nsv833715CNV Loss17160897

    Human Gene Mutation Database (HGMD): DAPK3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DAPK3
    DNA2.0 Custom Variant and Variant Library Synthesis for DAPK3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603289    OMIM disorders: --

    1 disease for DAPK3:    
    About MalaCards
    recessive dystrophic epidermolysis bullosa


    Find genes that share disorders with DAPK3           About GenesLikeMe

    1 Novoseek inferred disease relationship for DAPK3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 3 15140235 (1), 19117059 (1)

    Genetic Association Database (GAD): DAPK3

    Export disorders for DAPK3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAPK3 gene, integrated from 10 sources (see all 64):
    (articles sorted by number of sources associating them with DAPK3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. (PubMed id 9488481)1, 2, 3, 9 Kawai T.... Akira S. (Mol. Cell. Biol. 1998)
    2. ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. (PubMed id 12917339)1, 2, 9 Kawai T.... Reed J.C. (Mol. Cell. Biol. 2003)
    3. ZIP kinase plays a crucial role in androgen receptor-mediated transcription. (PubMed id 18084323)1, 2, 9 Leister P.... Scheidtmann K.H. (Oncogene 2008)
    4. Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase. (PubMed id 12560483)1, 2, 9 Preuss U.... Scheidtmann K.H. (Nucleic Acids Res. 2003)
    5. Novel ZIP kinase isoform lacks leucine zipper. (PubMed id 17126281)1, 2, 9 Takamoto N.... Ikebe M. (Arch. Biochem. Biophys. 2006)
    6. TCP10L is expressed specifically in spermatogenic cells and binds to death associated protein kinase-3. (PubMed id 15910542)1, 2, 9 Yu H.... Yu L. (Int. J. Androl. 2005)
    7. ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells. (PubMed id 10356987)1, 2, 9 Murata-Hori M.... Hosoya H. (FEBS Lett. 1999)
    8. Zipper-interacting protein kinase (ZIPK) modulates canonical Wnt/beta-catenin signaling through interaction with Nemo-like kinase and T-cell factor 4 (NLK/TCF4). (PubMed id 21454679)1, 2 Togi S.... Matsuda T. (J. Biol. Chem. 2011)
    9. Phosphorylation-dependent control of ZIPK nuclear import is species specific. (PubMed id 20854903)1, 2 Weitzel D.H.... Haystead T.A. (Cell. Signal. 2011)
    10. DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. (PubMed id 18995835)1, 2 Mukhopadhyay R.... Fox P.L. (Mol. Cell 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1613 HGNC: 2676 AceView: DAPK3 Ensembl:ENSG00000167657 euGenes: HUgn1613
    ECgene: DAPK3 Kegg: 1613 H-InvDB: DAPK3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DAPK3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DAPK3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DAPK3 gene:
    Search GeneIP for patents involving DAPK3

    Licensable Technologies for DAPK3 gene:
    Weizmann Institute:DAP Kinase Gene Family: A Novel Target for Treatment of Neurodegenerative Disorders and Cancer
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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