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Aliases & Descriptions for DAPK3
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| Dlk 3 | | EC 2.7.11.1 3 | | FLJ36473 2 | | ZIP 1, 2 | | ZIP-kinase 3 | | ZIPK 1, 2, 3 |
| | | Descriptions |
|---|
| DAP kinase 3 3 | | DAP-like kinase 3 | | ZIP kinase isoform 2 | | death-associated protein kinase 3 2 |
|
| | Search outside databases for aliases for DAPK3 genePrevious GC identifers: GC19M004050 GC19M003898 |
Summaries for DAPK3(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for DAPK3: Death-associated protein kinase 3 (DAPK3) induces morphological changes in apoptosis when overexpressed in mammalian cells. These results suggest that DAPK3 may play a role in the induction of apoptosis. [provided by RefSeq] UniProtKB/Swiss-Prot: DAPK3_HUMAN, O43293Function: Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosisGene Wiki entry for DAPK3 |
Genomic Location for DAPK3
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the DAPK3 gene 
Entrez Gene cytogenetic band: 19p13.3 Ensembl cytogenetic band: 19p13.3 HGNC cytogenetic band: 19p13.3DAPK3 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M003909:
(about GC identifiers)
Start:
|
3,909,452 bp from pter |
End:
|
3,920,826 bp from pter |
Size:
|
11,375 bases |
Orientation:
|
minus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011255.14
| Proteins for DAPK3
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: DAPK3_HUMAN, O43293 (See
protein sequence)Recommended Name: Death-associated protein kinase 3 Size: 454 amino acids; 52536 Da
Cofactor: Magnesium
Subunit: Homodimer or forms heterodimers with ATF4. Both interactions require an intact leucine zipper domain and oligomerization is required for full enzymatic activity. Also binds to DAXX and PAWR, possibly in a ternary complex which plays a role in caspase activation. Interacts with AATF and CDC5L
Subcellular location: Nucleus. Cytoplasm (By similarity). Note=Relocates to the cytoplasm on binding PAWR where the complex appears to interact with actin filaments (By similarity). Associates to centromeres from prophase to anaphase
PDB structures from and Proteopedia :1YRP (3D)
 2J90 (3D)
 3BHY (3D)
 3BQR (3D)
 
Secondary accessions: A0AVN4 B3KQE2Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_001339.1
ENSEMBL proteins: ENSP00000301264
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
2 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for DAPK3: Assays for DAPK3: | Protein
Domains/ Families for DAPK3(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry O43293
ProtoNet protein and cluster: O43293 UniProtKB/Swiss-Prot: DAPK3_HUMAN, O43293Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamilySimilarity: Contains 1 protein kinase domain | Gene Function for DAPK3
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001348
Applied Biosystems Silencer® siRNAs for DAPK3
Sigma-Aldrich siRNA and siRNA Panels for DAPK3  Sigma-Aldrich shRNA Panels and shRNA for DAPK3  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001348                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001348                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001348 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_001348
UniProtKB/Swiss-Prot: DAPK3_HUMAN, O43293Function: Serine/threonine kinase which acts as a positive regulator of apoptosis. Phosphorylates histone H3 on 'Thr-11' at centromeres during mitosisCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme Number (IUBMB): EC 2.7.11.1 5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for DAPK3
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
Gene Network CentralTM Interacting Genes and Proteins Network for DAPK3 
5/34 Interacting proteins for DAPK3 (O432931 ENSP000003012643) via UniProtKB, MINT, and/or STRING (see all 34
)About this table
5 Gene Ontology (GO) biological process terms (links to tree view): About this table
|
Drugs & Compounds for DAPK3(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for DAPK3 2 Novoseek chemical compound relationships for DAPK3 gene
About this table
|
Transcripts for DAPK3(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001348
Sigma-Aldrich siRNA and siRNA Panels for DAPK3  Sigma-Aldrich shRNA Panels and shRNA for DAPK3  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_001348 REFSEQ mRNAs for DAPK3 gene: NM_001348.1
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001348               OriGene GFP tagged cDNA clone in CMV expression vector: NM_001348                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_001348                                  untagged cDNA clones in CMV expression vector (see all 2): NM_001348  Additional cDNA sequence: AB007144.1 AB022341.1 AB265224.1 AK027590.1 AK074799.1 AK093792.1 AK097643.1 BC126430.1 BC126432.1 9 DOTS entries: DT.115342 DT.100780033 DT.100780036 DT.95270568 DT.121442910 DT.91763801 DT.95270565 DT.95209019 DT.40228801 24/179 AceView cDNA sequences (see all 179
):AB007144 AI814754 CD671566 BQ071749 BQ641366 AI765867 N23936 AW575746 AI656314 BM556428 AW009524 BM810947 NM_001348 BF976537 BQ187532 CD672363 AI468095 AI207294 CD672768 AI870742 AI652896 AI651663 CD676336 AI151467
highest scoring ESTs for DAPK3:AB007144 BE263312 BE713094 BG006550 BG421646 CB144331 AB022341 AK027590 AK074799 AA568989 Unigene Cluster for DAPK3: Death-associated protein kinase 3 Hs.631844 [show with all ESTs]Unigene Representative Sequence: AK027590
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for DAPK3
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2a | · | 2b | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8 | ^ | 9a | · | 9b | |
| SP1: | |   | |   | |   | - |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP4: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for DAPK3
1 Ensembl transcript including schematic representation: ENST00000301264
|
Expression for DAPK3
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| DAPK3 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for DAPK3
1 / 2 / 3 5 probe-sets matching DAPK3 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: TGGAGCATCG
SOURCE GeneReport for Unigene cluster: Hs.631844
Expression variation in blood from EXPOLDB for DAPK3 |
Orthologs for DAPK3
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DAPK3 gene from 5/8 species (see all 8
)
About this table Species with no ortholog for DAPK3
ENSEMBL Gene Tree for DAPK3 | Paralogs for DAPK3(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for DAPK3 gene
- DAPK22 DAPK12 MYLK2
|
SNPs/Variants for DAPK3(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for DAPK3 (up to first 250kb)
|
Disorders & Mutations for DAPK3
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 603289
1 Novoseek disease relationship for DAPK3 gene
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| tumors |
0.00 |
3 |
15140235 (1), 19117059 (1) |
About this table
|
Medical News for DAPK3(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for DAPK3 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/42 PubMed articles for DAPK3 gene (see all 42
):- ZIP kinase, a novel serine/threonine kinase which mediates apoptosis. (PubMed id 9488481)1, 2, 3, 4 Kawai T.... Akira S. (1998)
- ZIP kinase triggers apoptosis from nuclear PML oncogenic domains. (PubMed id 12917339)1, 3, 4 Kawai T.... Reed J.C. (2003)
- Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase. (PubMed id 12560483)1, 3, 4 Preuss U.... Scheidtmann K.H. (2003)
- ZIP kinase identified as a novel myosin regulatory light chain kinase in HeLa cells. (PubMed id 10356987)1, 3, 4 Murata-Hori M.... Hosoya H. (1999)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)3, 4 Ota T....Sugano S. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)3, 4 Gerhard D.S....Malek J. (2004)
- Phage-peptide display identifies the interferon-responsive, death-activated protein kinase family as a novel modifier of MDM2 and p21WAF1. (PubMed id 15001356)1, 3 Burch L.R....Hupp T. (2004)
- ZIP kinase plays a crucial role in androgen receptor-mediated transcription. (PubMed id 18084323)1, 3 Leister P....Scheidtmann K.H. (2008)
- Downregulation of ZIP kinase is associated with tumor invasion, metastasis and poor prognosis in gastric cancer. (PubMed id 19117059)1, 3 Bi J....Guan X.Y. (2009)
- Novel ZIP kinase isoform lacks leucine zipper. (PubMed id 17126281)1, 3 Takamoto N.... Ikebe M. (2006)
|
Search for DAPK3
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing DAPK3
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing DAPK3
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DAPK3(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| About This Section
| Licensable Technologies for DAPK3 gene:
| Services for DAPK3(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for DAPK3:

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| | | | Search Tocris compounds for DAPK3 |
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Incremental update: 13 Oct 2009
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