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DAPK2 Gene

protein-coding   GIFtS: 60
GCID: GC15M064199

Death-Associated Protein Kinase 2

  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Death-Associated Protein Kinase 21 2     DRP12
DRP-12 3     DAP-Kinase-Related Protein 1 Beta Isoform2
DAP Kinase 22 3     DAP-Kinase-Related Protein 13
EC 2.7.11.13 8     EC 2.7.118

External Ids:    HGNC: 26751   Entrez Gene: 236042   Ensembl: ENSG000000356647   UniProtKB: Q9UIK43   

Export aliases for DAPK2 gene to outside databases

Previous GC identifers: GC15M059986 GC15M057358 GC15M061778 GC15M061915 GC15M061986 GC15M041023


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAPK2 Gene:
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a
N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to
that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression
of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. (provided by RefSeq, Jul
2008)

GeneCards Summary for DAPK2 Gene:
DAPK2 (death-associated protein kinase 2) is a protein-coding gene. Diseases associated with DAPK2 include nasopharyngitis. GO annotations related to this gene include calmodulin binding and identical protein binding. An important paralog of this gene is STK17B.

UniProtKB/Swiss-Prot: DAPK2_HUMAN, Q9UIK4
Function: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways
that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell
deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is
caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of
anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells.
May play a role in granulocytic maturation
Function: Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and
autophagic cell death

Gene Wiki entry for DAPK2 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000015.10  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAPK2 gene promoter:
         AhR   MyoD   Roaz   Arnt   C/EBPalpha   CREB   POU2F1   POU2F1a   ZID   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAPK2 promoter sequence
   Search Chromatin IP Primers for DAPK2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAPK2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q22.31   Ensembl cytogenetic band:  15q22.31   HGNC cytogenetic band: 15q22.1

DAPK2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAPK2 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15M064199:  view genomic region     (about GC identifiers)

Start:
64,199,235 bp from pter      End:
64,364,232 bp from pter
Size:
164,998 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DAPK2_HUMAN, Q9UIK4 (See protein sequence)
Recommended Name: Death-associated protein kinase 2  
Size: 370 amino acids; 42898 Da
Cofactor: Magnesium
Subunit: Homodimer in its autoinhibited state. Active as monomer (By similarity). Isoform 2 but not isoform 1 can
interact with ATF4
Selected PDB 3D structures from and Proteopedia for DAPK2 (see all 8):
1WMK (3D)        1WRZ (3D)        1Z9X (3D)        1ZUZ (3D)        1ZWS (3D)        2A27 (3D)    
Secondary accessions: E9JGM7 O75892 Q24JS1
Alternative splicing: 2 isoforms:  Q9UIK4-1   Q9UIK4-2   (Contains a leucine zipper at positions 434-451)

Explore the universe of human proteins at neXtProt for DAPK2: NX_Q9UIK4

Explore proteomics data for DAPK2 at MOPED

Post-translational modifications: 

  • Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to
    activated Fas and TNF-alpha receptors1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DAPK2 (Q9UIK4) (see all 8)
     GDTKQET  GVITYILL  GTPEFVAPE  GEELGSGQFA 


    See DAPK2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_055141.2  
    ENSEMBL proteins: 
     ENSP00000453639   ENSP00000408277   ENSP00000453101   ENSP00000453235   ENSP00000453284  
     ENSP00000452970   ENSP00000261891  
    Reactome Protein details: Q9UIK4

    DAPK2 Human Recombinant Protein Products:

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    DAPK2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for DAPK2
    Cloud-Clone Corp. CLIAs for DAPK2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: death-associated protein kinase 2
    Death-associated kinase (DAPK) family

    Selected InterPro protein domains (see all 6):
     IPR017441 Protein_kinase_ATP_BS
     IPR002290 Ser/Thr_dual-sp_kinase_dom
     IPR011009 Kinase-like_dom
     IPR008271 Ser/Thr_kinase_AS
     IPR000719 Prot_kinase_dom

    Graphical View of Domain Structure for InterPro Entry Q9UIK4

    ProtoNet protein and cluster: Q9UIK4

    UniProtKB/Swiss-Prot: DAPK2_HUMAN, Q9UIK4
    Domain: The autoinhibitory domain sterically blocks the substrate peptide-binding site by making both hydrophobic
    and electrostatic contacts with the kinase core (By similarity)
    Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily
    Similarity: Contains 1 protein kinase domain


    DAPK2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAPK2_HUMAN, Q9UIK4
    Function: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways
    that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell
    deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is
    caspase-independent and is characterized by the accumulation of autophagic vesicles. Acts as a mediator of
    anoikis and a suppressor of beta-catenin-dependent anchorage-independent growth of malignant epithelial cells.
    May play a role in granulocytic maturation
    Function: Isoform 2 is not regulated by calmodulin. It can phosphorylate MYL9. It can induce membrane blebbing and
    autophagic cell death
    Catalytic activity: ATP + a protein = ADP + a phosphoprotein
    Enzyme regulation: Activated by Ca(2+)/calmodulin. Regulated by a double locking mechanism, involving
    autophosphorylation at Ser-318, calmodulin binding, and dimerization. In the inactive state, Ser-318 is
    phosphorylated, and the kinase is dimeric. Activation involves: dephosphorylation at Ser-318,
    release-of-autoinhibition mechanism where calmodulin binding induces a conformational change that relieves the
    steric block of the active site by the autoinhibitory domain, and generation of the monomeric active form of the
    kinase
    Induction: Up-regulated during granulocytic maturation

         Enzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112

         Gene Ontology (GO): Selected molecular function terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003824catalytic activity ----
    GO:0004672protein kinase activity ----
    GO:0004674protein serine/threonine kinase activity TAS16756490
    GO:0004683calmodulin-dependent protein kinase activity IBA--
    GO:0004713protein tyrosine kinase activity ----
         
    DAPK2 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for DAPK2:
     Decreased focal adhesion (FA)   Decreased substrate adherent c  G0/1 arrest  Increased G1 DNA content 

         1 MGI phenotypic allele for Dapk2 (no phenotypes)

    DAPK2 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DAPK2
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DAPK2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAPK2

    miRNA
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    miRTarBase miRNAs that target DAPK2:
    hsa-mir-335-5p (MIRT016960)

    Block miRNA regulation of human, mouse, rat DAPK2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAPK2 (see all 24):
    hsa-miR-513a-5p hsa-miR-106a hsa-miR-4314 hsa-miR-133a hsa-miR-93 hsa-miR-3662 hsa-miR-520g hsa-miR-526b*
    SwitchGear 3'UTR luciferase reporter plasmidDAPK2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DAPK2
    Predesigned siRNA for gene silencing in human, mouse, rat DAPK2

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: DAPK2 (NM_014326)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAPK2

    Cell Line
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAPK2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DAPK2_HUMAN, Q9UIK4: Cytoplasm. Cytoplasmic vesicle, autophagosome lumen
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    vacuole5
    cytosol3
    nucleus2
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA10376525
    GO:0031410cytoplasmic vesicle IEA--
    GO:0034423autophagic vacuole lumen IEA--

    DAPK2 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAPK2 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1CDK-mediated phosphorylation and removal of Cdc6
    Regulation of Apoptosis0.82
    Role of DCC in regulating apoptosis0.00
    Apoptosis0.38
    2Glioma
    Bladder cancer0.31
    3Pathways in cancer
    Pathways in cancer

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for DAPK2
        Role of DCC in regulating apoptosis


    2 Kegg Pathways  (Kegg details for DAPK2):
        Pathways in cancer
    Bladder cancer


    DAPK2 for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Array including DAPK2: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DAPK2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 13)

    Selected Interacting proteins for DAPK2 (Q9UIK41, 3 ENSP000002618914) via UniProtKB, MINT, STRING, and/or I2D (see all 18)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MLC1Q150493, ENSP000003103754I2D: score=1 STRING: ENSP00000310375
    TGFBR1P368973, ENSP000003641334I2D: score=3 STRING: ENSP00000364133
    CSNK1A1P487293I2D: score=1 
    CSNK1EP496743I2D: score=1 
    NKD1Q969G93I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006468protein phosphorylation IDA10376525
    GO:0006915apoptotic process TAS10629061
    GO:0010506regulation of autophagy TAS16756490
    GO:0035556intracellular signal transduction IDA10376525
    GO:0042981regulation of apoptotic process TAS16756490

    DAPK2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAPK2

    4 HMDB Compounds for DAPK2    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    CalciumCa (see all 2)7440-70-2--
    MagnesiumMagnesium (see all 2)7439-95-4--

    2 Novoseek inferred chemical compound relationships for DAPK2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    threonine 61.4 2 11230133 (1), 17139808 (1)
    serine 49.8 2 11230133 (1), 17139808 (1)



    DAPK2 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DAPK2 gene: 
    NM_014326.3  

    Unigene Cluster for DAPK2:

    Death-associated protein kinase 2
    Hs.237886  [show with all ESTs]
    Unigene Representative Sequence: BC114951
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559007(uc010uim.2) ENST00000457488 ENST00000559731 ENST00000558064
    ENST00000557867 ENST00000558069 ENST00000558076 ENST00000558482(uc010bgu.1)
    ENST00000559897 ENST00000561162 ENST00000559306 ENST00000261891(uc002amr.3)

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    hsa-miR-513a-5p hsa-miR-106a hsa-miR-4314 hsa-miR-133a hsa-miR-93 hsa-miR-3662 hsa-miR-520g hsa-miR-526b*
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      QuantiFast Probe-based Assays in human, mouse, rat DAPK2

    Additional mRNA sequence: 

    AB018001.1 AF052941.1 AK026801.1 AK094290.1 AK310967.1 BC114506.1 BC114951.1 GU056176.1 

    4 DOTS entries:

    DT.304225  DT.75141877  DT.91684430  DT.95161584 

    Selected AceView cDNA sequences (see all 31):

    NM_014326 AB018001 AA327032 AI362933 CB153964 BP345940 AA989377 AW004707 
    AI138960 AW058406 AF052941 AI764982 AI499351 BX644667 BU687995 AA594637 
    AK026801 AA858002 BI464915 AW022329 AU100378 AA952879 BE883503 AA937590 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAPK2 expression in normal human tissues (normalized intensities)      DAPK2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DAPK2 Expression
    About this image


    DAPK2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Blood (Hematopoietic System)
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)
             Myelinating Oligodendrocyte Cells Forebrain White Matter
     
     Colon (Gastrointestinal Tract)
    DAPK2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAPK2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.237886

    UniProtKB/Swiss-Prot: DAPK2_HUMAN, Q9UIK4
    Tissue specificity: Isoform 2 is expressed in embryonic stem cells (at protein level). Isoform 1 is ubiquitously
    expressed in all tissue types examined with high levels in heart, lung and skeletal muscle. It is expressed
    abundantly in cells differentiated toward granulocytes and low in undifferentiated, normal and leukemic
    hematopoietic cells and monocytes/macrophages

        Pathway & Disease-focused RT2 Profiler PCR Array including DAPK2: 
              Apoptosis 384HT in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat DAPK2
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAPK2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DAPK2 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dapk21 , 5 death-associated protein kinase 21, 5 91.8(n)1
    97.3(a)1
      9 (35.75 cM)5
    131431  NM_010019.31  NP_034149.21 
     661582235 
    chicken
    (Gallus gallus)
    Aves DAPK26
    death-associated protein kinase 2
    54(a)
    1 ↔ 1
    10(3366148-3406151)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    57(a)
    many ↔ many
    GL343637.1(101470-110594)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia 1420194212   -- 79.29(n)    142019421 
    zebrafish
    (Danio rerio)
    Actinopterygii im:71629651 im:7162965 72.58(n)
    77.01(a)
      556756  XM_679634.5  XP_684726.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta bt6
    bent
    2(a)
    many ↔ many
    4(745030-796707)
    worm
    (Caenorhabditis elegans)
    Secernentea dapk-16
    Protein DAPK-1 (dapk-1) mRNA, complete cds
    11(a)
    1 → many
    I(1305575-1328228) WBGene00003400
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons PEPKR21 PEPKR2 47.66(n)
    38.67(a)
      837824  NM_101138.3  NP_172728.1 
    rice
    (Oryza sativa)
    Liliopsida Os09g04669001 Os09g0466900 47.34(n)
    36.58(a)
      4347317  NM_001069956.1  NP_001063421.2 


    ENSEMBL Gene Tree for DAPK2 (if available)
    TreeFam Gene Tree for DAPK2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAPK2 gene
    STK17B2  MYLK22  TTN2  STK17A2  MYLK32  OBSCN2  DAPK32  SPEG2  
    MYLK42  DAPK12  MYLK2  
    Selected SIMAP similar genes for DAPK2 using alignment to 6 protein entries:     DAPK2_HUMAN (see all proteins) (see all similar genes):
    ZNF480    LRRC36    SUN3    THADA    NUSAP1    DAPK1
    HKR1    IFT122    SCLT1    DAPK3    BUB1B    MTA3
    UTY    WDR6    CES4A    COX7A2    KLHDC1    ARV1

    DAPK2 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAPK2 (see all 2940)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs596462991,2
    C--41150119(+) GGGGA-/GGGGGA
            
    AGGGG
    1 -- int11Minor allele frequency- GGGGGA:0.00NA 2
    rs564112491,2
    C--44368261(+) AAAAA-/A/A   
       A
    /AAA
    CATTC
    2 -- int1 cds11NA 2
    rs15506591,2
    C,F,O,A,H--64199073(-) CCCCTC/TCGGTG 1 -- ds500122Minor allele frequency- N:0.00MN NS EA NA WA CSA 1454
    rs64944521,2
    C,F,A,H--64199208(+) gggccG/Accata 1 -- ds500119Minor allele frequency- A:0.18NS EA NA WA 2140
    rs1157944271,2
    C,F--64199269(+) ACAATT/GTTTGA 1 -- ut311Minor allele frequency- G:0.05WA 118
    rs589548291,2
    C,F--64199323(+) TGAGGC/ACCCCT 1 -- ut311Minor allele frequency- A:0.50WA 2
    rs1826340501,2
    --64199338(+) TTGTCA/GATGGC 1 -- ut310--------
    rs1395836731,2
    C--64199440(+) GGCCCA/GTATCA 1 -- ut310--------
    rs1455202251,2
    --64199703(+) AGCCTC/TGACCT 1 -- ut310--------
    rs1150652831,2
    C,F--64199812(+) ACTGCG/ATTTTG 1 -- ut312Minor allele frequency- A:0.03WA NA 238

    HapMap Linkage Disequilibrium report for DAPK2 (64199235 - 64364232 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DAPK2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv1568CNV Insertion18451855
    esv1414761CNV Insertion17803354
    nsv1569CNV Loss18451855
    nsv1567CNV Loss18451855

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DAPK2
    DNA2.0 Custom Variant and Variant Library Synthesis for DAPK2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for DAPK2:    About MalaCards
    nasopharyngitis


    DAPK2 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for DAPK2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 6.8 2 11230133 (1), 11980920 (1)
    tumors 0 1 11980920 (1)


    Export disorders for DAPK2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAPK2 gene, integrated from 10 sources (see all 32):
    (articles sorted by number of sources associating them with DAPK2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Death-associated protein kinase 2 is a new calcium/calmodulin- dependent protein kinase that signals apoptosis through its catalytic activity. (PubMed id 10376525)1, 2, 3 Kawai T.... Akira S. (Oncogene 1999)
    2. Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis. (PubMed id 10629061)1, 2, 9 Inbal B.... Kimchi A. (Mol. Cell. Biol. 2000)
    3. DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. (PubMed id 11980920)1, 2, 9 Inbal B.... Kimchi A. (J. Cell Biol. 2002)
    4. Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding. (PubMed id 11230133)1, 2, 9 Shani G.... Kimchi A. (EMBO J. 2001)
    5. New modularity of DAP-kinases: alternative splicing of the DRP-1 gene produces a ZIPk-like isoform. (PubMed id 21408167)1, 2 Shoval Y.... Pietrokovski S. (PLoS ONE 2011)
    6. Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells. (PubMed id 18957423)1, 2 Li H.... Rosen K.V. (J. Biol. Chem. 2009)
    7. The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells. (PubMed id 17347302)1, 2 Rizzi M.... Tobler A. (J. Leukoc. Biol. 2007)
    8. The death-associated protein kinases: structure, function, and beyond. (PubMed id 16756490)1, 2 Bialik S. and Kimchi A. (Annu. Rev. Biochem. 2006)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. The tumor suppressor gene DAPK2 is induced by the myeloid transcription factors PU.1 and C/EBPI+ during granulocytic differentiation but repressed by PML-RARI+ in APL. (PubMed id 24038216)1 Humbert M....Tschan M.P. (J. Leukoc. Biol. 2014)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23604 HGNC: 2675 AceView: DAPK2 Ensembl:ENSG00000035664 euGenes: HUgn23604
    ECgene: DAPK2 Kegg: 23604 H-InvDB: DAPK2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DAPK2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DAPK2 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DAPK2 gene:
    Search GeneIP for patents involving DAPK2

    Licensable Technologies for DAPK2 gene:
    Weizmann Institute:DAP Kinase Gene Family: A Novel Target for Treatment of Neurodegenerative Disorders and Cancer
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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