DAPK2 Gene
protein-coding GIFtS: 57
GCID: GC15M064199
|
|
death-associated protein kinase 2
| |
Aliases
for DAPK2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Death-Associated Protein Kinase 21 2 | | DRP12 | | DRP-11 2 3 | | DAP-Kinase-Related Protein 1 Beta Isoform2 | | DAP Kinase 22 3 | | DAP-Kinase-Related Protein 13 | | EC 2.7.11.13 8 | | EC 2.7.118 | | MGC1193121 | | |
Export aliases for DAPK2 gene to outside databasesPrevious GC identifers: GC15M059986 GC15M057358 GC15M061778 GC15M061915 GC15M061986 GC15M041023 |
Summaries
for DAPK2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for DAPK2:
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains aN-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to thatof death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of thisgene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: DAPK2_HUMAN, Q9UIK4Function: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways thattrigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deathssignal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independentand is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor ofbeta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocyticmaturationFunction: Isoform 2 can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell death
Gene Wiki entry for DAPK2
|
Genomic Views
for DAPK2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000015.9 NC_018926.1 NT_010194.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the DAPK2 gene promoter:
AhR MyoD Roaz Arnt C/EBPalpha CREB POU2F1 POU2F1a ZID Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for DAPK2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAPK2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 15q22.31 Ensembl cytogenetic band: 15q22.31 HGNC cytogenetic band: 15q22.1DAPK2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 15 GeneLoc Exon Structure GeneLoc location for GC15M064199: view genomic region
(about GC identifiers)
Start:
|
64,199,235 bp from pter |
End:
|
64,364,232 bp from pter |
Size:
|
164,998 bases |
Orientation:
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minus strand |
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Proteins
for DAPK2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: DAPK2_HUMAN, Q9UIK4 (See
protein sequence)Recommended Name: Death-associated protein kinase 2 Size: 370 amino acids; 42898 Da
Cofactor: Magnesium
Subunit: Homodimer in its autoinhibited state. Active as monomer (By similarity). Isoform 2 but not isoform 1 caninteract with ATF4
Subcellular location: Cytoplasm. Cytoplasmic vesicle, autophagosome lumen
6/8 PDB 3D structures from  and Proteopedia  for DAPK2 (see all 8):1WMK (3D)
1WRZ (3D)
1Z9X (3D)
1ZUZ (3D)
1ZWS (3D)
2A27 (3D)
Secondary accessions: O75892 Q24JS1Alternative splicing: 2 isoforms: Q9UIK4-1 Q9UIK4-2 Explore the universe of human proteins at neXtProt for DAPK2: NX_Q9UIK4
Post-translational modifications:
Autophosphorylation at Ser-318 inhibits its catalytic activity. Dephosphorylated at Ser-318 in response to activatedFas and TNF-alpha receptors1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9UIK4
4/8 DME Specific Peptides for DAPK2 (Q9UIK4) (see all 8)
DAPK2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_055141.2
ENSEMBL proteins: ENSP00000453639 ENSP00000408277 ENSP00000453101 ENSP00000453235 ENSP00000453284 ENSP00000452970 ENSP00000261891 Reactome Protein details: Q9UIK4
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
DAPK2 for ontologies About GeneDecksing
DAPK2 Antibody Products:
Assay Products for DAPK2: |
Protein
Domains /
Families
for DAPK2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
DAPK2 for domains About GeneDecksing
5/6 InterPro domains/families (see all 6):Graphical View of Domain Structure for InterPro Entry Q9UIK4ProtoNet protein and cluster: Q9UIK4 UniProtKB/Swiss-Prot: DAPK2_HUMAN, Q9UIK4Domain: The autoinhibitory domain sterically blocks the substrate peptide-binding site by making both hydrophobic andelectrostatic contacts with the kinase core (By similarity)Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamilySimilarity: Contains 1 protein kinase domain |
Function
for DAPK2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: DAPK2_HUMAN, Q9UIK4Function: Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways thattrigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deathssignal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independentand is characterized by the accumulation of autophagic vesicles. Acts as a mediator of anoikis and a suppressor ofbeta-catenin-dependent anchorage-independent growth of malignant epithelial cells. May play a role in granulocyticmaturationFunction: Isoform 2 can phosphorylate MYL9. It can induce membrane blebbing and autophagic cell deathCatalytic activity: ATP + a protein = ADP + a phosphoproteinEnzyme regulation: Activated by Ca(2+)/calmodulin. Regulated by a double locking mechanism, involvingautophosphorylation at Ser-318, calmodulin binding, and dimerization. In the inactive state, Ser-318 isphosphorylated, and the kinase is dimeric. Activation involves: dephosphorylation at Ser-318,release-of-autoinhibition mechanism where calmodulin binding induces a conformational change that relieves the stericblock of the active site by the autoinhibitory domain, and generation of the monomeric active form of the kinaseInduction: Up-regulated during granulocytic maturationEnzyme Numbers (IUBMB): EC 2.7.11.11 2 EC 2.7.112
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAPK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DAPK2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for DAPK2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAPK2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAPK2 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
DAPK2 for ontologies About GeneDecksing
4 GenomeRNAi human phenotypes for DAPK2:
Animal Models:
1 MGI phenotypic allele  for Dapk2 (no phenotypes)
DAPK2 for phenotypes About GeneDecksing
|
Pathways & Interactions
for DAPK2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Ubiquitinated Orc1 is degraded by the proteasome | | | 2 | Role of DCC in regulating apoptosis | | | 3 | Bladder cancer | | | 4 | Pathways in cancer | |
Pathway sources
See GeneCards unified pathways
Show all pathways
3 
Reactome Pathways for DAPK2
2 
Kegg Pathways (Kegg details for DAPK2):
DAPK2 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DAPK2
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5/10 Interacting proteins for DAPK2 (Q9UIK41, 3 ENSP000002618914) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
DAPK2 for ontologies About GeneDecksing
|
Drugs & Compounds
for DAPK2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
DAPK2 for compounds About GeneDecksing
 Browse Tocris compounds for DAPK2
4 HMDB Compounds for DAPK2 About this table
2 Novoseek chemical compound relationships for DAPK2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| threonine |
61.4 |
2 |
11230133 (1), 17139808 (1) |
| serine |
49.8 |
2 |
11230133 (1), 17139808 (1) |
Search CenterWatch for drugs/clinical trials and news about DAPK2
|
Transcripts
for DAPK2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for DAPK2 gene: NM_014326.3 Unigene Cluster for DAPK2: Death-associated protein kinase 2 Hs.237886 [show with all ESTs]Unigene Representative Sequence: BC11495112 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000559007(uc010uim.2) ENST00000457488 ENST00000559731 ENST00000558064
ENST00000557867 ENST00000558069 ENST00000558076 ENST00000558482(uc010bgu.1)
ENST00000559897 ENST00000561162 ENST00000559306 ENST00000261891(uc002amr.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAPK2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DAPK2
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: DAPK2 (NM_014326) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DAPK2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAPK2 |
Additional cDNA sequence: AB018001.1 AF052941.1 AK026801.1 AK094290.1 AK310967.1 BC114506.1 BC114951.1 GU056176.1 4 DOTS entries: DT.304225 DT.75141877 DT.91684430 DT.95161584 24/31 AceView cDNA sequences (see all 31): AI362933 AA327032 AA989377 CB153964 NM_014326 BP345940 AB018001 AA858002 AW058406 AI499351 AI764982 AA594637 AK026801 BX644667 BU687995 AI138960 AW004707 AF052941 BI464915 AW022329 AU100378 BE883503 AA952879 BI491627
GeneLoc Exon Structure
|
Expression
for DAPK2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| DAPK2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See DAPK2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DAPK2
SOURCE GeneReport for Unigene cluster: Hs.237886
UniProtKB/Swiss-Prot: DAPK2_HUMAN, Q9UIK4Tissue specificity: Isoform 2 is expressed in embryonic stem cells (at protein level). Isoform 1 is ubiquitouslyexpressed in all tissue types examined with high levels in heart, lung and skeletal muscle. It is expressed abundantlyin cells differentiated toward granulocytes and low in undifferentiated, normal and leukemic hematopoietic cells andmonocytes/macrophages
SABiosciences Expression via Pathway-Focused PCR Array including DAPK2:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DAPK2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DAPK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAPK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAPK2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAPK2 |
Orthologs
for DAPK2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for DAPK2 gene from 5/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
chicken
(Gallus gallus) |
Aves |
DAPK21 |
death-associated protein kinase 2 |
78.3(n)
85.6(a) |
|
100857587 XM_003641874.1 XP_003641922.1 |
tropical clawed frog
(Xenopus tropicalis) |
Amphibia |
1420194212 |
-- |
79.29(n) |
|
142019421 |
zebrafish
(Danio rerio) |
Actinopterygii |
im:71629651 |
im:7162965 |
72.74(n)
76.42(a) |
|
556756 XM_679634.4 XP_684726.4 |
honey bee
(Apis mellifera) |
Insecta |
-- |
-- |
52(a) |
1 → many |
GroupUn.7053(7765-8871) |
worm
(Caenorhabditis elegans) |
Secernentea |
dapk-16 |
Death-associated protein kinase dapk-1 |
12(a) |
1 → many |
I(1305577-1328230) |
ENSEMBL Gene Tree for DAPK2 (if available)
TreeFam Gene Tree for DAPK2 (if available) |
Paralogs
for DAPK2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for DAPK2 gene
- STK17B2 MYLK22 TTN2 MYLK32 STK17A2 OBSCN2 DAPK32 SPEG2
- MYLK42 DAPK12 MYLK2 OBSL12
18/132 SIMAP similar genes for DAPK2 using alignment to 7 protein entries: DAPK2_HUMAN (see all proteins)
(see all similar genes):LRRC36 SUN3 THADA DAPK1 NUSAP1 HKR1
IFT122 SCLT1 BUB1B MTA3 UTY WDR6
CES4A COX7A2 DAPK3 KLHDC1 ARV1 C19orf25
DAPK2 for paralogs About GeneDecksing
|
Genomic Variants
for DAPK2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 15 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for DAPK2 (64199235 - 64364232 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DAPK2: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DAPK2 |
|
Disorders
/ Diseases
for DAPK2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Novoseek,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
DAPK2 for disorders About GeneDecksing
5  diseases for DAPK2: About MalaCardsurinary bladder cancer gastric cancer nasopharyngitis neuronitis
carcinoma
2 Novoseek disease relationships for DAPK2 gene About this table
| Disease |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| necrosis |
6.8 |
2 |
11230133 (1), 11980920 (1) |
| tumors |
0 |
1 |
11980920 (1) |
Export disorders for DAPK2 gene to outside databases
|
Publications
for DAPK2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for DAPK2 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with DAPK2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Death-associated protein kinase 2 is a new calcium/calmodulin- dependent protein kinase that signals apoptosis through its catalytic activity. (PubMed id 10376525)1, 2, 3 Kawai T.... Akira S. (1999)
- Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis. (PubMed id 10629061)1, 2, 9 Inbal B.... Kimchi A. (2000)
- DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death. (PubMed id 11980920)1, 2, 9 Inbal B....Kimchi A. (2002)
- Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding. (PubMed id 11230133)1, 2, 9 Shani G.... Kimchi A. (2001)
- New modularity of DAP-kinases: alternative splicing o f the DRP-1 gene produces a ZIPk-like isoform. (PubMed id 21408167)1, 2 Shoval Y....Pietrokovski S. (2011)
- Down-regulation of death-associated protein kinase-2 is required for beta-catenin-induced anoikis resistance of malignant epithelial cells. (PubMed id 18957423)1, 2 Li H....Rosen K.V. (2009)
- The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells. (PubMed id 17347302)1, 2 Rizzi M....Tobler A. (2007)
- The death-associated protein kinases: structure, func tion, and beyond. (PubMed id 16756490)1, 2 Bialik S. and Kimchi A. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Sodium butyrate-induced DAPK-mediated apoptosis in hum an gastric cancer cells. (PubMed id 22160140)1 Shin H....Lee Y.C. (2012)
|
External Searches for DAPK2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing DAPK2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing DAPK2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DAPK2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for DAPK2 gene:
Search GeneIP for patents involving DAPK2
Licensable Technologies for DAPK2 gene:GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for DAPK2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for DAPK2 | | OriGene shRNA RFP for DAPK2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAPK2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DAPK2 | | | OriGene Protein Over-expression Lysate for DAPK2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for DAPK2 | | OriGene 3'-UTR Clone for DAPK2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DAPK2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAPK2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for DAPK2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for DAPK2 | | OriGene Custom Protein Services for DAPK2 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DAPK2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DAPK2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAPK2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAPK2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAPK2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAPK2 |
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| | | | Search Tocris compounds for DAPK2 |
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 | | | DAPK2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAPK2 |
|  |  |  | | | | ThermoFisher Antibodies for DAPK2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAPK2 |
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