DAPK1 Gene
protein-coding GIFtS : 74 GCID: GC09 P090112
death-associated protein kinase 1
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Aliasesfor DAPK1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Death-Associated Protein Kinase 1 1 2 DAPK1 2 3 DAP Kinase 12 3 EC 2.7.11.13 8 EC 2.7.118
Export aliases for DAPK1 gene to outside databases Previous GC identifers: GC09P081156 GC09P081966 GC09P083667 GC09P085569 GC09P087342 GC09P089301 GC09P059938
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Summariesfor DAPK1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for DAPK1 : Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: DAPK1_HUMAN, P53355 Function : Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways thattrigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition Function : Isoform 2 cannot induce apoptosis but can induce membrane blebbingsummary
for DAPK1 : Death associated protein kinase (DAPk) is a serine/threonine kinase involved in numerous mechanisms andpathways linked to cell death and autophagy. Loss of expression of the gene encoding DAPk has been observedin multiple tumor types, and it has consequently been of interest in cancer research. Gene Wiki entry for DAPK1
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Genomic Viewsfor DAPK1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,miRBase ,UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000009.11 NC_018920.1 NT_008470.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DAPK1 gene promoter:AhR AML1a MyoD AP-2gamma Egr-4 Arnt Gfi-1 AP-2beta Other transcription factors Search SABiosciences Chromatin IP Primers for DAPK1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 9q21.33 Ensembl cytogenetic band: 9q21.33 HGNC cytogenetic band: 9q34.1 DAPK1 Gene in genomic location: bands according to Ensembl, locations according to
Entrez Gene Ensembl GeneLoc information about chromosome 9 GeneLoc Exon Structure
GeneLoc location for GC09P090112: view genomic region
(about GC identifiers )
Start: 90,112,143 bp from pter End:
90,323,549 bp from pter
Size: 211,407 bases Orientation:
plus strand
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Proteinsfor DAPK1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DAPK1_HUMAN, P53355 See
protein sequence )Recommended Name: Size : 1430 amino acids; 160046 DaCofactor : MagnesiumSubunit : Interacts with KLHL20. Interacts (via death domain) with MAPK1 and MAPK3. Interacts with MAP1B (viaN-terminus). Interacts (via death domain) with UNC5B (via death domain). Interacts with PRKD1 in an oxidative stress-regulated manner. Interacts with PIN1, PDCD6, BECN1, GRINB, TSC2 and STX1A. Interacts (via kinase domain) with DAPK3 (via kinase domain)
Subcellular location : Isoform 1: Cytoplasm. Cytoplasm, cytoskeleton. Note=Colocalizes with MAP1B in the microtubulesand cortical actin fibers
Subcellular location : Isoform 2: Cytoplasm. Cytoplasm, cytoskeletonSequence caution : Sequence=AAP35581.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknownorigin in the C-terminal part; Sequence=CAA53712.1; Type=Frameshift; Positions=462, 464;
6/32 PDB 3D structures from (see all 32 ):1IG1 (3D) 1JKK (3D) 1JKL (3D) 1JKS (3D) 1JKT (3D) 1P4F (3D) Secondary accessions : B7ZLD2 Q14CQ7 Q1W5W0 Q68CP8 Q6ZRZ3 Q9BTL8Alternative splicing : 3 isoforms : P53355-1 P53355-2 P53355-3 Explore the universe of human proteins at neXtProt for DAPK1: NX_P53355 Post-translational modifications:
Ubiquitinated by the BCR(KLHL20) E3 ubiquitin ligase complex, leading to its degradation by the proteasome1 Removal of the C-terminal tail of isoform 2 (corresponding to amino acids 296-337 of isoform 2) by proteolytic cleavage stimulates maximally its membrane-blebbing function1
In response to mitogenic stimulation (PMA or EGF), phosphorylated at Ser-289; phosphorylation suppresses DAPK1 pro-apoptotic function. Autophosphorylation at Ser-308 inhibits its catalytic activity. Phosphorylation at Ser-734 by MAPK1 increases its catalytic activity and promotes cytoplasmic retention of MAPK1. Endoplasmic-stress can cause dephosphorylation at Ser-3081
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_P53355 4/9 DME Specific Peptides for DAPK1 (P53355 ) (see all 9 )DAPK1 Protein expression data from MOPED and PaxDb : About this image REFSEQ proteins: NP_004929.2 ENSEMBL proteins: ENSP00000350785 ENSP00000417076 ENSP00000386135 ENSP00000419026 ENSP00000417746 ENSP00000418885 Reactome Protein details: P53355 Human Recombinant Protein Products for DAPK1: Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view) : About this table
About GeneDecksing DAPK1 Antibody Products: Assay Products for DAPK1:
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Protein
Domains /for DAPK1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section About GeneDecksing 5/11 InterPro domains/families (see all 11 ):
Graphical View of Domain Structure for InterPro Entry P53355 ProtoNet protein and cluster: P53355
1 Blocks protein family : IPB000488 UniProtKB/Swiss-Prot: DAPK1_HUMAN, P53355 Domain : The autoinhibitory domain sterically blocks the substrate peptide-binding site by making both hydrophobic andelectrostatic contacts with the kinase core Similarity : Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamilySimilarity : Contains 10 ANK repeatsSimilarity : Contains 1 death domainSimilarity : Contains 1 protein kinase domain
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Functionfor DAPK1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: DAPK1_HUMAN, P53355 Function : Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways thattrigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress fiber formation in endothelial cells. Phosphorylates STX1A and significantly decreases its binding to STXBP1. Phosphorylates PRKD1 and regulates JNK signaling by binding and activating PRKD1 under oxidative stress. Phosphorylates BECN1, reducing its interaction with BCL2 and BCL2L1 and promoting the induction of autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex and stimulating mTORC1 activity in a growth factor-dependent pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling amplifier of NMDA receptors at extrasynaptic sites for mediating brain damage in stroke. Cerebral ischemia recruits DAPK1 into the NMDA receptor complex and it phosphorylates GRINB at Ser-1303 inducing injurious Ca(2+) influx through NMDA receptor channels, resulting in an irreversible neuronal death. Required together with DAPK3 for phosphorylation of RPL13A upon interferon-gamma activation which is causing RPL13A involvement in transcript-selective translation inhibition Function : Isoform 2 cannot induce apoptosis but can induce membrane blebbingCatalytic activity : ATP + a protein = ADP + a phosphoproteinEnzyme regulation : Activated by Ca(2+)/calmodulin. Regulated by a locking mechanism, involving autophosphorylation atSer-308 and calmodulin binding. In the inactive state, Ser-308 is phosphorylated. Activation involves its dephosphorylation and a release-of-autoinhibition mechanism where binding of calmodulin induces a conformational change that relieves the steric block of the active site by the autoinhibitory domain. Activity is modulated by UNC5B and NTN1. UNC5B activates it by inhibiting the phosphorylation at Ser-308, whereas NTN1 inhibits UNC5B-mediated activation of DAPK1. Endoplasmic-stress activates by causing Ser-308 dephosphorylation Induction : Up-regulated following treatment with IFNG/IFN-gamma
Genatlas biochemistry entry for DAPK1 DAP kinase,160kDa,coupling the control of apoptosis to metastasis,triggered by IFNG,localized to the actin microfilament network Enzyme Numbers (IUBMB): EC 2.7.11.1 1 2 EC 2.7.11 2 Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6 ): About this table
About GeneDecksing Phenotypes: 5 GenomeRNAi human phenotypes for DAPK1 :4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dapk1) :About GeneDecksing Animal Models: Dapk1 tm1Yuk Dapk1 tm1Akc Clone Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DAPK1 (NM_004938 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DAPK1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DAPK1
In Situ AssayAdvanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAPK1
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Pathways & Interactionsfor DAPK1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Unified GeneCards pathways - 5/9 super-pathways (see all 9 ) About this table See pathways by source Super-pathway contained gene-specific pathways 1 Ubiquitinated Orc1 is degraded by the proteasome 2 Apoptosis and Autophagy 3 Role of DCC in regulating apoptosis 4 Selected targets of p53 5 Selected targets of C/EBPbeta
Pathway sources See GeneCards unified pathways Show all pathways 2 1 1 1 3 2 (Kegg details for DAPK1) :About GeneDecksing Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAPK1 STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)5/48 Interacting proteins for DAPK1 (P53355 1 , 2 , 3 ENSP00000350785 4 via UniProtKB, MINT, STRING , and/or I2D (see all 48 )Interactant Interaction Details GeneCard External ID(s) TSC2 P49815 2 , 3 ENSP00000219476 4 MINT-8057232 MINT-8057213 I2D:
score=2 STRING: ENSP00000219476 DAPK1 P53355 1 , 2 EBI-358616,EBI-358616 MINT-7014515 MINT-8204891 MINT-8204873 MAPK3 P27361 1 , 3 ENSP00000263025 4 EBI-358616,EBI-73995 I2D:
score=5 STRING: ENSP00000263025 CUL3 Q13618 2 , 3 ENSP00000264414 4 MINT-7900697 I2D:
score=2 STRING: ENSP00000264414 RIPK3 Q9Y572 2 , 3 MINT-49138 I2D:
score=2
About this table Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14 ): About this table
About GeneDecksing
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Drugs & Compoundsfor DAPK1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section About GeneDecksing Compounds for DAPK1 available from Tocris Bioscience About this table Compound Action
CAS
# TC-DAPK 6 Potent and selective inhibitor of DAPK1 [315694-89-4]
2 HMDB Compounds for DAPK1 About this table 3 DrugBank Compounds for DAPK1 About this table 10/11 Novoseek chemical compound relationships for DAPK1 gene (see all 11 ) About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
o6-methylguanine
70.4
7
12845678 (1), 19513524 (1), 19302404 (1), 15068392 (1) (see all 7 )
5-aza-2'deoxycytidine
68
12
19778817 (3), 16094112 (1), 12912953 (1), 16520653 (1) (see all 5 )
sodium bisulfite
63.9
2
17898258 (1), 18026971 (1)
threonine
53.3
21
18583991 (1), 19878310 (1), 20206532 (1), 16204252 (1) (see all 20 )
serine
37.1
18
18583991 (1), 20206532 (1), 16204252 (1), 16476779 (1) (see all 17 )
retinoic acid
36.6
14
12845678 (1), 17285579 (1), 17696735 (1), 15797047 (1) (see all 12 )
crcs
31.4
1
16819711 (1)
5-methylcytosine
30.3
1
12154064 (1)
calcium
0
8
16204252 (2), 14505650 (1), 16213824 (1), 19022289 (1) (see all 5 )
methionine
0
1
15589597 (1)
DAPK1
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Transcriptsfor DAPK1 gene (Secondary structures according to
fRNAdb ,Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC , GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,EMD Millipore ,
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DAPK1 gene: NM_004938.2 Unigene Clusters for DAPK1:
Death-associated protein kinase 1 Hs.380277 [show with all ESTs ] , Hs.693441 Unigene Representative Sequences: NM_004938 , EF090258 18 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000358077 ENST00000472284 (uc004apc.3 ) ENST00000469067 (uc004ape.3 )ENST00000495182 ENST00000408954 ENST00000470267 ENST00000496522 ENST00000472344 ENST00000491893 (uc004apf.1 ) ENST00000489291 ENST00000463069 ENST00000475804 ENST00000495281 ENST00000494010 ENST00000466188 ENST00000497743 ENST00000468482 ENST00000469640 (uc004apd.3 uc011ltg.2 uc011lth.2 ) Clone OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat see all 4 )human mouse rat see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DAPK1 (NM_004938 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DAPK1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DAPK1
Additional cDNA sequence: EF090258.1
14 DOTS entries : DT.449320 DT.92433148
DT.40121399 DT.95229766 DT.75124125 DT.97813727 DT.97810796 DT.121189199 DT.91839838 DT.91862442 DT.97773110 DT.100658969 DT.102839048 DT.92433149 24/217 AceView cDNA sequences (see all 217 ):
BE302335 CK904559 AI969709 CR605555 AW513135 AW118366 F04423 BE018772 T17486 AA455493 BE502994 AI655412 BG413577 T29354 BI711145 BM682968 AL531618 AI242189 BF110628 CB121221 AL707694 AW304956 BX337929 BX096066 GeneLoc Exon Structure 5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DAPK1 (see all 8 ) About this scheme ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ SP1 : - - - - SP2 : SP3 : - - SP4 : SP5 : - -
ExUns: 22a · 22b ^ 23 ^ 24 ^ 25 ^ 26a · 26b ^ 27a · 27b ^ 28 ^ 29 SP1 : - - - SP2 : SP3 : SP4 : - - SP5 :
ECgene alternative splicing isoforms for DAPK1
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Expression for DAPK1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DAPK1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TAATGTTAATAbout this image DAPK1 expression in embryonic tissues and stem cells About this table
See DAPK1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DAPK1 SOURCE GeneReport for Unigene clusters: Hs.380277 Hs.693441 UniProtKB/Swiss-Prot: DAPK1_HUMAN, P53355 Tissue specificity : Isoform 2 is expressed in normal intestinal tissue as well as in colorectal carcinomasSABiosciences Expression via Pathway-Focused PCR Arrays including DAPK1 (see all 7 ): Primer OriGene genome-wide validated SYBR primer pairs in human mouse rat Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat In Situ Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAPK1
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Orthologsfor DAPK1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section Orthologs for DAPK1 gene from 5/19 species (see all 19 ) About this table
Organism
Taxonomic
Gene
Description
Human
Orthology
Details
chicken Aves DAPK11
death-associated protein kinase 1
79.92(n) 91.02(a)
431670 NM_001031613.1 NP_001026784.1
lizard Reptilia DAPK16
--
88(a)
1 ↔ 1
2(40965160-41045807)
zebrafish Actinopterygii dapk11
death-associated protein kinase 1
69.4(n) 75.26(a)
558314 NM_001099990.2 NP_001093460.1
honey bee Insecta --
--
54(a)
1 → many
GroupUn.7053(7765-8871)
worm Secernentea ZC373.43 1
calcium/calmodulin dependent protein kinase3 1
38(a) 3 46.1(n) 1 35.91(a) 1
X(10098022-10105019)3 187322 1 NM_058439.3 1 NP_490840.2 1
ENSEMBL Gene Tree for DAPK1 (if available)TreeFam Gene Tree for DAPK1 (if available)
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Paralogsfor DAPK1 gene (Paralogs according to
1 HomoloGene ,2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DAPK1 gene STK17B 2 DAPK2 2 MYLK2 2 TTN 2 MYLK3 2 STK17A 2 OBSCN 2 DAPK3 2 SPEG 2 MYLK4 2 MYLK 2 OBSL1 2 18/83 SIMAP similar genes for DAPK1 using alignment to 5 protein entries: DAPK1_HUMAN (see all proteins )
(see all similar genes ):DAPK3 DAPK2 STK17A BRSK2 RPS6KA4 STK17B MYLK4 NUAK1 PRKAA1 PHKG2 KIAA0999 MARK4 STK36 RPS6KA1 CAMKV PNCK STK32A TTN About GeneDecksing 1 Pseudogenes.org Pseudogene for DAPK1 PGOHUM00000236238
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Genomic Variantsfor DAPK1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical Chr 9 pos Sequence # AA Type More # Allele Pop Total More
HapMap Linkage Disequilibrium report for DAPK1 (90112143 - 90323549 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 10 variations for DAPK1 4 CNVs 70755 0129 3775 70754 6 Indels 29204 29202 33479 29203 70753 34350 Human Gene Mutation Database (HGMD) : DAPK1 SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human mouse rat
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Disorders
/ Diseasesfor DAPK1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section About GeneDecksing OMIM gene information: 600831
OMIM disorders : --20/87 (see all 87 ): About MalaCards central nervous system lymphoma diffuse large b-cell lymphoma familial adenomatous polyposis choroid plexus papilloma b-cell lymphomas temporal lobe epilepsy cervical squamous cell carcinoma squamous cell carcinoma urinary bladder cancer pilocytic astrocytoma adenoid cystic carcinoma oral squamous cell carcinoma lymphoblastic leukemia malt lymphoma myeloid leukemia benign tumors pediatric lymphoma adenoiditis carcinoma ependymoma 1 disease from the University of Copenhagen DISEASES database for DAPK1 :Carcinoma 10/56 Novoseek disease relationships for DAPK1 gene (see all 56 ) About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
tumors
59.8
161
16476779 (6), 15099958 (4), 16094112 (4), 17803936 (3) (see all 79 )
cancer
54.8
39
19878310 (3), 16256792 (2), 16142356 (2), 16928264 (2) (see all 23 )
nsclc
51.9
30
19926549 (3), 19795445 (3), 19653236 (2), 15797047 (2) (see all 13 )
bladder cancer
48
14
19778817 (5), 11839665 (2), 15569975 (2), 18070176 (1) (see all 6 )
cervical cancer
47.9
29
18425396 (5), 18799028 (4), 16803511 (4), 16928264 (3) (see all 12 )
primary tumor
47.5
5
12684406 (2), 17570703 (1), 11309270 (1), 12684420 (1)
cervical squamous cell carcinoma
45.8
3
18799028 (1), 16142356 (1)
carcinoma squamous cell
41.2
6
19926549 (1), 15099958 (1), 16142356 (1), 11448914 (1) (see all 6 )
cancer lung
40
25
20360646 (6), 12912953 (4), 19781081 (2), 15709192 (1) (see all 10 )
pleural effusion malignant
37.1
4
17285579 (1), 17696735 (1)
Genetic Association Database (GAD): DAPK1 Human Genome Epidemiology (HuGE) Navigator: DAPK1 (14 documents) Export disorders for DAPK1 gene to outside databases
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Publicationsfor DAPK1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DAPK1 gene, integrated from 9 sources (see all 367 ):(articles sorted by number of sources associating them with DAPK1) Utopia : connect your pdf to the dynamic
The Cullin 3 substrate adaptor KLHL20 mediates DAPK ubiquitination to control interferon responses. (PubMed id 20389280) 1 , 2 , 9(2010) Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK. (PubMed id 15616583) 1 , 2 , 9(2005) Control of death-associated protein kinase (DAPK) activity by phosphorylation and proteasomal degradation. (PubMed id 17056602) 1 , 2 , 9(2006) An alternative transcript from the death-associated protein kinase 1 locus encoding a small protein selectively mediates membrane blebbing. (PubMed id 18422656) 1 , 2 , 9(2008) The tumor suppressor DAP kinase is a target of RSK-mediated survival signaling. (PubMed id 16213824) 1 , 2 , 9(2005) DAP-kinase-mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl-XL and induction of autophagy. (PubMed id 19180116) 1 , 2 , 9(2009) DAPK-ZIPK-L13a axis constitutes a negative-feedback module regulating inflammatory gene expression. (PubMed id 18995835) 1 , 2 , 9(2008) Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. (PubMed id 21497122) 1 , 2 (2011) Peptide combinatorial libraries identify TSC2 as a death-associated protein kinase (DAPK) death domain-binding protein and reveal a stimulatory role for DAPK in mTORC1 signaling. (PubMed id 18974095) 1 , 2 (2009) DAPK-1 binding to a linear peptide motif in MAP1B stimulates autophagy and membrane blebbing. (PubMed id 18195017) 1 , 2 (2008)
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External Searches for DAPK1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DAPK1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DAPK1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DAPK1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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About This Section Patent Information for DAPK1 gene: DAPK1 Licensable Technologies for DAPK1 gene: GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DAPK1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
OriGene Antibodies for DAPK1 OriGene shRNA RFP for DAPK1 OriGene 29mer shRNA kits in GFP-retroviral vector in human mouse rat OriGene genome-wide validated SYBR primer pairs in human mouse rat OriGene Protein Over-expression Lysate for DAPK1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DAPK1 OriGene 3'-UTR Clone for DAPK1 OriGene untagged cDNA clones in CMV expression vector in human mouse rat OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human mouse rat Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for DAPK1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DAPK1 OriGene Custom Protein Services for DAPK1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DAPK1 QIAGEN SeqTarget long-range PCR primers in human mouse rat QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human mouse rat QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human mouse rat QIAGEN QuantiFast Probe-based Assays in human mouse rat QIAGEN QuantiTect SYBR Green Assays in human mouse rat
Antibodies & Assays for DAPK1
Tocris compounds for DAPK1
DAPK1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAPK1
ThermoFisher Antibodies for DAPK1
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DAPK1
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summary
for 
and Proteopedia 
for DAPK1 (
BioSystems Pathway for DAPK1 
Kegg Pathways 
Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine 
Negative
Selective marker
Curated
In-situ hybridization
