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DAPK1 Gene

protein-coding GIFtS: 72

GC09P089301

death-associated protein kinase 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
DAPK ^¹, ², ³
DKFZp781I035 ^²
EC 2.7.11.1 ^³

Descriptions
DAP kinase 1 ^³
death-associated protein kinase 1 ^²

External Ids
HGNC: 2674¹
Entrez Gene: 1612²
UniProtKB: P53355³
Ensembl: ENSG00000196730⁷

Search outside databases for aliases for DAPK1 gene

Previous GC identifers: GC09P081156 GC09P081966 GC09P083667 GC09P085569 GC09P087342

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DAPK1:

Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed

cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine

kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor

suppressor candidate. [provided by RefSeq]

UniProtKB/Swiss-Prot: DAPK1_HUMAN, P53355

Function: Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator

of apoptosis

Gene Wiki entry for DAPK1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DAPK1 gene

Entrez Gene cytogenetic band: 9q34.1 Ensembl cytogenetic band: 9q21.33 HGNC cytogenetic band: 9q34.1

DAPK1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P089301: (about GC identifiers)

Start:	89,302,576 bp from pter
End:	89,513,369 bp from pter
Size:	210,794 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_023935.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DAPK1_HUMAN, P53355 (See protein sequence)

Recommended Name: Death-associated protein kinase 1

Size: 1430 amino acids; 160073 Da

Cofactor: Magnesium

Subcellular location: Cytoplasm. Note=Colocalizes with the actin filament system

Sequence caution: Sequence=CAA53712.1; Type=Frameshift; Positions=462, 464;

PDB structures from and Proteopedia :

1IG1 (3D)

1JKK (3D)

1JKL (3D)

1JKS (3D)

1JKT (3D)

1P4F (3D)

1WVW (3D)

1WVX (3D)

1WVY (3D)

1YR5 (3D)

3EH9 (3D)

3EHA (3D)

3F5G (3D)

3F5U (3D)

Secondary accessions: Q14CQ7 Q68CP8 Q9BTL8

Alternative splicing: 2 isoforms: P53355-1 P53355-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004929.2

ENSEMBL proteins:

ENSP00000350785 ENSP00000386135

Human Recombinant Proteins

	Invitrogen human recombinant proteins for DAPK1
	Millipore Purified and/or Recombinant DAPK1 Protein
	Sigma-Aldrich Proteins for DAPK1
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DAP Kinase 1)
	Human Recombinant Proteins from Abnova (DAPK1)

OriGene Purified Recombinant Human Protein: DAPK1

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IEA	--
GO:0015629	actin cytoskeleton	IDA	10629061

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Antibodies for DAPK1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of DAPK1
	Sigma-Aldrich Antibody Arrays and Antibodies for DAPK1
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for DAPK1 (DAPK1 Kinase)
	Antibodies from Abcam (DAP Kinase 1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DAPK1)
	Novus Biologicals Antibodies for DAPK1

Assays for DAPK1:

	Invitrogen Assays for DAPK1
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P53355

ProtoNet protein and cluster: P53355

1 Blocks protein family: IPB000488 Death domain

UniProtKB/Swiss-Prot: DAPK1_HUMAN, P53355

Similarity: Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP

kinase subfamily

Similarity: Contains 10 ANK repeats

Similarity: Contains 1 death domain

Similarity: Contains 1 protein kinase domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAPK1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DAPK1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004938

Applied Biosystems Silencer® siRNAs for DAPK1

Sigma-Aldrich siRNA and siRNA Panels for DAPK1

Sigma-Aldrich shRNA Panels and shRNA for DAPK1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004938
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004938
untagged cDNA clones in CMV expression vector (see all 2): NM_004938

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004938

UniProtKB/Swiss-Prot: DAPK1_HUMAN, P53355

Function: Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator

of apoptosis

Catalytic activity: ATP + a protein = ADP + a phosphoprotein

Enzyme regulation: Negatively regulated by autophosphorylation on Ser-308

Induction: Up-regulated following treatment with interferon-gamma

Enzyme Number (IUBMB): EC 2.7.11.1

Genatlas biochemistry entry for DAPK1:

DAP kinase,160kDa,coupling the control of apoptosis to metastasis,triggered by IFNG,localized to

the actin microfilament network

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dapk1):

cellular

renal/urinary system

5 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0004674	protein serine/threonine kinase activity	IEA	--
GO:0005516	calmodulin binding	IDA	10629061
GO:0005524	ATP binding	IDA	10629061
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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3 Sigma-Aldrich "Your Favorite Gene" Pathways for DAPK1 (Your Favorite Gene powered by Ingenuity)

Nicotinate and Nicotinamide Metabolism
Inositol Phosphate Metabolism
Bladder Cancer Signaling

GeneDecks DAPK1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for DAPK1

5/6 Interacting proteins for DAPK1 (P53355^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 6 )
Interactant Interaction Details
GeneCard External ID(s)
MAPK3 P27361¹ EBI-358616, EBI-73995
PDCD6 O75340¹ EBI-358616, EBI-352915
BECN1 Q14457² MINT-7014496 MINT-7014569 MINT-7014553 MINT-7014531
BCL2 P10415² MINT-7014531
DAPK1 P53355² MINT-7014515
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5 Gene Ontology (GO) biological process terms (links to tree view):
GO ID Qualified GO term Evidence PubMed IDs
GO:0006468 protein amino acid phosphorylation IDA 10629061
GO:0006916 anti-apoptosis IEA --
GO:0007165 signal transduction IEA --
GO:0007243 protein kinase cascade IDA 10629061
GO:0008624 induction of apoptosis by extracellular signals TAS 7828849
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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DAPK1
6 Novoseek chemical compound relationships for DAPK1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
o6-methylguanine	68.31	5	12845678 (1), 15068392 (1), 16870044 (1), 15197802 (1) (see all 5)
threonine	49.44	16	18583991 (1), 16204252 (1), 16476779 (1), 17803936 (1) (see all 15)
crcs	36.47	1	16819711 (1)
5-methylcytosine	33.99	1	12154064 (1)
calcium	0.00	8	16204252 (2), 14505650 (1), 16213824 (1), 19022289 (1) (see all 5)
methionine	0.00	1	15589597 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAPK1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DAPK1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004938

Sigma-Aldrich siRNA and siRNA Panels for DAPK1

Sigma-Aldrich shRNA Panels and shRNA for DAPK1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004938

REFSEQ mRNAs for DAPK1 gene:

NM_004938.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004938

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004938
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004938
                                 untagged cDNA clones in CMV expression vector (see all 2): NM_004938

Additional cDNA sequence: EF090258.1

14 DOTS entries:

DT.449320 DT.92433148 DT.40121399 DT.95229766 DT.75124125 DT.97813727 DT.97810796 DT.121189199

DT.91839838 DT.91862442 DT.97773110 DT.100658969 DT.102839048 DT.92433149

24/217 AceView cDNA sequences (see all 217 ):

BX337929 AI678988 BQ645922 T29354 BE502994 AL531618 AI378628 BX096066

CK904559 BM682968 W60210 AW674416 AW072599 AW304956 T17329 AI375765

AL708910 AI679983 BF110628 AW663351 AL707694 CB121221 BE302335 AI242189

highest scoring ESTs for DAPK1:

X76104 AA024655 AA025275 AA333288 AA337408 AA367971 AA455492 AA455493 AA846231 AA912826

Unigene Clusters for DAPK1:

Death-associated protein kinase 1

Hs.380277 [show with all ESTs], Hs.693441

Unigene Representative Sequences: NM_004938, EF090258

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DAPK1 (see all 8 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7	^	8	^	9	^	10	^	11	^	12	^	13	^	14	^	15	^	16a	·	16b	^	17	^	18	^	19	^	20	^	21	^
SP1:							-				-		-																										-
SP2:
SP3:											-		-
SP4:
SP5:							-				-

ExUns:	22a	·	22b	^	23	^	24	^	25	^	26a	·	26b	^	27a	·	27b	^	28	^	29
SP1:			-		-						-
SP2:
SP3:
SP4:									-		-
SP5:

About this scheme

ECgene alternative splicing isoforms for DAPK1

2 Ensembl transcripts including schematic representations:

ENST00000358077 ENST00000408954

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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DAPK1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DAPK1

¹ / ² / ³

6 probe-sets matching DAPK1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
40049_at²^{, 3}	U95-A	1	1.00	1.00	0.91	1.07	X76104	1.00	1.00	1.00	1
48214_at²^{, 3}	U95-B	1	0.75	1.00	-0.04	0.95	N23367	0.60	1.00	0.82	1
211214_s_at²	U133-A	1	1.00	1.00	--	--	--	--	--	--	--
203139_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004938	0.60	1.00	0.82	1
211214_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
203139_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks DAPK1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TATGGAATCC

SOURCE GeneReport for Unigene clusters: Hs.380277 Hs.693441
Expression variation in blood from EXPOLDB for DAPK1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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Orthologs for DAPK1 gene from 5/10 species (see all 10 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DAPK1¹	--	death-associated protein kinase 1	89.81(n) 95.52(a)	484142 XM_541259.2 XP_541259.2
chimpanzee (Pan troglodytes)	DAPK1¹	--	death-associated protein kinase 1	99.21(n) 99.86(a)	464571 XM_001140200.1 XP_001140200.1
cow (Bos taurus)	DAPK1¹	--	death-associated protein kinase 1	91.76(n) 96.62(a)	540873 XM_613544.3 XP_613544.3
rat (Rattus norvegicus)	Dapk1¹	--	death associated protein kinase 1	87.6(n) 95.03(a)	306722 XM_225138.3 XP_225138.3
mouse (Mus musculus)	Dapk1^{1, 5}	13 (40.00 cM)⁵	death associated protein kinase 1^{1, 5}	87.67(n)¹ 95.1(a)¹	69635¹ NM_134062.1¹ NP_598823.1¹ AI507519⁵ AI642003⁵ (see all 24)

About this table Species with no ortholog for DAPK1

ENSEMBL Gene Tree for DAPK1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for DAPK1 gene

DAPK2² DAPK3² MYLK²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/1938 NCBI SNPs in DAPK1 are shown (see all 1938 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 561)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1056719^1,2	A,C,F,H,O	89511843(+)	`CACCAA/GTAACG`	1	S/N	mis¹ ese³		17	MN EA NA EU WA NS	1538
--	rs1329600^1,2	A,C,F,H,O	89302273(-)	`TTCTTT/CCGTCC`	1	--	ng5¹		6	MN EU EA WA NS	616
	rs13283425^1,2	A,C,F,H	89513040(+)	`CCCTTA/GTAATT`	1	--	ut3¹ ese³		5	NS EU EA WA	446
	rs7868357^1,2	A,C,F,H	89512789(+)	`TGTTTT/CGTTTG`	1	--	ut3¹		8	NA EU EA WA NS	590
	rs7028853^1,2	A,C,F,H	89513407(+)	`TTTTAC/TTTGTT`	1	--	ng3¹		5	EU EA WA NS	440
--	rs1964911^1,2	A,C,F,H	89300645(-)	`ATCCTA/CGTCTT`	1	--	ng5¹		4	EU EA WA	418
	rs7028878^1,2	C,F,H	89513479(+)	`TACACC/TTCAAC`	1	--	ng3¹		5	EU EA WA NS	442
	rs12343465^1,2	C,F,H	89452055(+)	`ATGCCG/ATCTAC`	1	I/V	mis¹ ese³		9	EU EA WA NS	868
	rs2302791^1,2	C,F	89302713(-)	`ATCCCT/CCCCAG`	1	--	ut5¹		2	EA NS	1512
	rs9410941^1,2	F,H	89513624(+)	`AAAAAC/ACAAAC`	1	--	ng3¹		4	EU EA WA	418

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HapMap Linkage Disequilibrium images for DAPK1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 600831

10/51 Novoseek disease relationships for DAPK1 gene (see all 51 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	58.22	133	16476779 (6), 15099958 (4), 16094112 (4), 17803936 (3) (see all 67)
cancer	52.46	30	16256792 (2), 16142356 (2), 16928264 (2), 16043258 (1) (see all 19)
nsclc	51.70	18	17606310 (2), 15797047 (2), 15542809 (2), 14737938 (2) (see all 10)
primary tumor	49.61	5	12684406 (2), 17570703 (1), 11309270 (1), 12684420 (1)
cervical squamous cell carcinoma	49.22	3	18799028 (1), 16142356 (1)
bladder cancer	47.74	8	11839665 (2), 15569975 (2), 18070176 (1), 11751381 (1) (see all 5)
cervical cancer	44.66	25	18425396 (5), 18799028 (4), 16803511 (4), 16928264 (3) (see all 8)
pleural effusion malignant	40.49	4	17285579 (1), 17696735 (1)
cancer lung	37.89	12	12912953 (4), 15709192 (1), 12684406 (1), 16870044 (1) (see all 8)
microsatellite instability	37.41	1	16819711 (1)

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1 PharmGKB disease relationship for DAPK1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

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Human Gene Mutation Database: DAPK1
Genetic Association Database: DAPK1
Human Genome Epidemiology Navigator: DAPK1 (6 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/253 PubMed articles for DAPK1 gene (see all 253 ):

The pro-apoptotic function of death-associated protein kinase is controlled by a unique inhibitory autophosphorylation-based mechanism. (PubMed id 11579085)^{3, 4} Shohat G.... Kimchi A. (2001)
Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis. (PubMed id 10629061)^{3, 4} Inbal B.... Kimchi A. (2000)
Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. (PubMed id 7828849)^{3, 4} Deiss L.P....Kimchi A. (1995)
Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively. (PubMed id 8530096)^{2, 3} Feinstein E....Huebner K. (1995)
Promoter methylation of death-associated protein kinase and its role in irradiation response in cervical cancer. (PubMed id 18425396)^{1, 3} Leung R.C....Ngan H.Y. (2008)
Promoter methylation and down-regulation of DAPK is associated with gastric atrophy. (PubMed id 14612952)^{1, 3} Kim W.S....Park C. (2003)
The tumor suppressor death-associated protein kinase targets to TCR-stimulated NF-kappaB activation. (PubMed id 18292548)^{1, 3} Chuang Y.T....Lai M.Z. (2008)
Bidirectional signals transduced by DAPK-ERK interaction promote the apoptotic effect of DAPK. (PubMed id 15616583)^{1, 3} Chen C.H....Chen R.H. (2005)
Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes. (PubMed id 17324930)^{1, 3} Zhang L....Gallagher P.J. (2007)
Reduced expression of death-associated protein kinase in human uterine and ovarian carcinoma cells. (PubMed id 14767518)^{1, 3} Bai T....Umesaki N. (2004)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1612	HGNC: 2674	AceView: DAPK1	Ensembl:ENSG00000196730	euGenes: HUgn1612
ECgene: DAPK1	H-InvDB: DAPK1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for DAPK1	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for DAPK1
(Available from WIS Yeda, Salk, Tufts)

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Licensable Technologies for DAPK1 gene:

Weizmann Institute:

DAP Kinase Gene Family: A Novel Target for Treatment of Neurodegenerative Disorders and Cancer

(see all 2)

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for DAPK1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DAPK1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DAPK1		Antibodies for DAPK1
	Explore super-pooled esiRNAs		Proteins for DAPK1
	Lentivirus-delivered shRNAs for DAPK1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (DAPK1)
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	Custom Service for Rabbit Pab from Full-length Protein

Antibodies & Assays for DAPK1 (DAPK1 Kinase)

	Recombinant Proteins (DAP Kinase 1)
	Antibodies (DAP Kinase 1)

	Tagged/untagged cDNA clones
	Validated SYBR primer pairs
	Purified proteins from HEK293T cells
	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for DAPK1

Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies

Antibodies for DAPK1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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DAPK1 Gene at Home site.
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DAPK1 Gene

protein-coding GIFtS: 72

Aliases &
Descriptions
for DAPK1

Summaries
for DAPK1

Genomic Location
for DAPK1

Proteins
for DAPK1

Protein Domains/
Families
for DAPK1

Gene Function
for DAPK1

Pathways & Interactions
for DAPK1

Drugs & Compounds
for DAPK1

Transcripts
for DAPK1

Expression
for DAPK1

Orthologs
for DAPK1

Paralogs
for DAPK1

SNPs/Variants
for DAPK1

Disorders & Mutations
for DAPK1

Medical News
for DAPK1

Publications
for DAPK1

Search for DAPK1

Genome Databases showing DAPK1

Other Databases showing DAPK1

Specialized Databases showing DAPK1

Licensable Technologies
for DAPK1

Services
for DAPK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DAPK1 Gene

protein-coding GIFtS: 72

Aliases & Descriptionsfor DAPK1

Summariesfor DAPK1

Genomic Locationfor DAPK1

Proteinsfor DAPK1

Protein Domains/Familiesfor DAPK1

Gene Functionfor DAPK1

Pathways & Interactionsfor DAPK1

Drugs & Compoundsfor DAPK1

Transcriptsfor DAPK1

Expression for DAPK1

Orthologsfor DAPK1

Paralogsfor DAPK1

SNPs/Variantsfor DAPK1

Disorders & Mutationsfor DAPK1

Medical Newsfor DAPK1

Publicationsfor DAPK1

Search for DAPK1

Genome Databases showing DAPK1

Other Databases showing DAPK1

Specialized Databases showing DAPK1

Licensable Technologiesfor DAPK1

Servicesfor DAPK1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DAPK1

Summaries
for DAPK1

Genomic Location
for DAPK1

Proteins
for DAPK1

Protein Domains/
Families
for DAPK1

Gene Function
for DAPK1

Pathways & Interactions
for DAPK1

Drugs & Compounds
for DAPK1

Transcripts
for DAPK1

Expression
for DAPK1

Orthologs
for DAPK1

Paralogs
for DAPK1

SNPs/Variants
for DAPK1

Disorders & Mutations
for DAPK1

Medical News
for DAPK1

Publications
for DAPK1

Licensable Technologies
for DAPK1

Services
for DAPK1