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DAP3 Gene

protein-coding   GIFtS: 64
GCID: GC01P155657

Death Associated Protein 3

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Death Associated Protein 31 2     MRP-S292 3
Mitochondrial 28S Ribosomal Protein S291 2     MRPS292 3
Death-Associated Protein 32 3     S29mt2 3
Ionizing Radiation Resistance Conferring Protein2 3     28S Ribosomal Protein S29, Mitochondrial2
DAP-32 3     bMRP-102

External Ids:    HGNC: 26731   Entrez Gene: 78182   Ensembl: ENSG000001326767   OMIM: 6020745   UniProtKB: P513983   
ORGUL members:         

Export aliases for DAP3 gene to outside databases

Previous GC identifers: GC01P153522 GC01P151406 GC01P152436 GC01P152875 GC01P152471 GC01P153925 GC01P127020


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAP3 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis
factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional
partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct
isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and
2q. (provided by RefSeq, Dec 2010)

GeneCards Summary for DAP3 Gene:
DAP3 (death associated protein 3) is a protein-coding gene.

UniProtKB/Swiss-Prot: RT29_HUMAN, P51398
Function: Involved in mediating interferon-gamma-induced cell death

Gene Wiki entry for DAP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAP3 gene promoter:
         GR   GR-alpha   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAP3 promoter sequence
   Search Chromatin IP Primers for DAP3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

DAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155657:  view genomic region     (about GC identifiers)

Start:
155,657,751 bp from pter      End:
155,708,801 bp from pter
Size:
51,051 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: RT29_HUMAN, P51398 (See protein sequence)
Recommended Name: 28S ribosomal protein S29, mitochondrial precursor  
Size: 398 amino acids; 45566 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins. Interacts with KIAA0141. Interacts with NOA1
Sequence caution: Sequence=AAA57443.1; Type=Frameshift; Positions=349;
Secondary accessions: B4DP59 B4DY62 E7EM60 Q13044 Q68CT7 Q96Q20
Alternative splicing: 3 isoforms:  P51398-1   P51398-2   P51398-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DAP3: NX_P51398

Explore proteomics data for DAP3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DAP3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (5 alternative transcripts): 
    NP_001186778.1  NP_001186779.1  NP_001186780.1  NP_004623.1  NP_387506.1  

    ENSEMBL proteins: 
     ENSP00000476592   ENSP00000476899   ENSP00000357320   ENSP00000341692   ENSP00000412605  
     ENSP00000476889   ENSP00000476816   ENSP00000476291   ENSP00000476840   ENSP00000477025  
     ENSP00000477265   ENSP00000476558   ENSP00000476624   ENSP00000477139   ENSP00000477453  
     ENSP00000476706   ENSP00000445003  

    DAP3 Human Recombinant Protein Products:

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    Novus Biologicals DAP3 Proteins
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    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DAP3

     
    Search eBioscience for Proteins for DAP3 

     
    antibodies-online proteins for DAP3 (7 products) 

     
    antibodies-online peptides for DAP3

    DAP3 Antibody Products:

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    antibodies-online antibodies for DAP3 (46 products) 

    DAP3 Assay Products:

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    antibodies-online kits for DAP3 (3 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    MRPS: Mitochondrial ribosomal proteins / small subunits

    3 InterPro protein domains:
     IPR008092 Ribosomal_S29_mit
     IPR019368 Ribosomal_S23/S29_mit
     IPR027417 P-loop_NTPase

    Graphical View of Domain Structure for InterPro Entry P51398

    ProtoNet protein and cluster: P51398

    1 Blocks protein domain: IPB008092 Death associated protein 3 family signature


    Find genes that share domains with DAP3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RT29_HUMAN, P51398
    Function: Involved in mediating interferon-gamma-induced cell death

         Genatlas biochemistry entry for DAP3:
    death associated protein 3,ubiquitously expressed,involved in mediating interferon gamma induced apoptosis,and as
    well as TNF and TNFRSF6 induced cell death,acting upstream caspases

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19103604
    GO:0044822poly(A) RNA binding IDA--
         
    Find genes that share ontologies with DAP3           About GenesLikeMe


    Phenotypes:
         4 GenomeRNAi human phenotypes for DAP3:
     Decreased influenza A/WSN/33 r  Increased G2M DNA content  Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dap3):
     cellular  embryogenesis  growth/size/body  hematopoietic system  mortality/aging 

    Find genes that share phenotypes with DAP3           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DAP3

    miRNA
    Products:
        
    miRTarBase miRNAs that target DAP3:
    hsa-mir-324-5p (MIRT043117), hsa-mir-615-3p (MIRT040466), hsa-mir-106b-5p (MIRT044320), hsa-mir-16-5p (MIRT031739), hsa-mir-1296-5p (MIRT036140)

    Block miRNA regulation of human, mouse, rat DAP3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate DAP3:
    hsa-miR-548s hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidDAP3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DAP3
    Predesigned siRNA for gene silencing in human, mouse, rat DAP3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DAP3

    Clone
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    OriGene clones in human, mouse for DAP3 (see all 11)
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    GenScript: all cDNA clones in your preferred vector (see all 5): DAP3 (NM_033657)
    Sino Biological Human cDNA Clone for DAP3
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAP3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for DAP3
    Browse ESI BIO Cell Lines and PureStem Progenitors for DAP3 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAP3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    RT29_HUMAN, P51398: Mitochondrion
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion5
    nucleus4

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix ----
    GO:0005761mitochondrial ribosome IEA--

    Find genes that share ontologies with DAP3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAP3 About    
    See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    TRAIL Pathway0.40
    2FAS (CD95) signaling pathway
    TRAIL signaling pathway0.30
    3all-trans-Retinoic Acid Mediated Apoptosis
    all-trans-Retinoic Acid Mediated Apoptosis

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DAP3
        TRAIL Pathway
    all-trans-Retinoic Acid Mediated Apoptosis

    1 BioSystems Pathway for DAP3
        TRAIL signaling pathway



        Pathway & Disease-focused RT2 Profiler PCR Array including DAP3: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DAP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DAP3 (P513981, 2, 3 ENSP000003416924) via UniProtKB, MINT, STRING, and/or I2D (see all 294)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K92, 3MINT-48164 I2D: score=2 
    NFKB2Q006532, 3MINT-48720 I2D: score=2 
    ICT1Q141972, 3, ENSP000003015854MINT-8079752 MINT-8079764 MINT-8079030 MINT-8079734 I2D: score=1 STRING: ENSP00000301585
    MRPL3P090012MINT-8079752 MINT-8079764 MINT-8079030 MINT-8079734
    NOA1Q8NC601, 2, ENSP000002642304EBI-355912,EBI-717871 MINT-8079030 STRING: ENSP00000264230
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008637apoptotic mitochondrial changes IEA--
    GO:0097190apoptotic signaling pathway TAS7499268

    Find genes that share ontologies with DAP3           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAP3 (RT29)

    1 Novoseek inferred chemical compound relationship for DAP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 25.4 1 15908146 (1)



    Find genes that share compounds with DAP3           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DAP3 gene (5 alternative transcripts): 
    NM_001199849.1  NM_001199850.1  NM_001199851.1  NM_004632.3  NM_033657.2  

    Unigene Cluster for DAP3:

    Death associated protein 3
    Hs.516746  [show with all ESTs]
    Unigene Representative Sequence: NM_001199849
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000461479 ENST00000471642 ENST00000471214 ENST00000479076 ENST00000368336(uc001fls.3 uc001flr.3 uc010pgl.2 uc010pgm.2 uc001flq.3)
    ENST00000343043 ENST00000496863 ENST00000421487 ENST00000465375 ENST00000462002
    ENST00000470830 ENST00000463575 ENST00000497826 ENST00000471523 ENST00000608852
    ENST00000479151 ENST00000466384 ENST00000462978
    miRNA
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    Block miRNA regulation of human, mouse, rat DAP3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate DAP3:
    hsa-miR-548s hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidDAP3 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DAP3
    Predesigned siRNA for gene silencing in human, mouse, rat DAP3
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    OriGene ORF clones in mouse, rat for DAP3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 5): DAP3 (NM_033657)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAP3
    Primer
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    OriGene qPCR primer pairs and template standards for DAP3
    OriGene qSTAR qPCR primer pairs in human, mouse for DAP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DAP3
      QuantiTect SYBR Green Assays in human, mouse, rat DAP3
      QuantiFast Probe-based Assays in human, mouse, rat DAP3

    Additional mRNA sequence: 

    AK225869.1 AK293117.1 AK298201.1 AK302281.1 BC107487.1 BC107488.1 BT019494.1 CR749790.1 
    U18321.1 X83544.1 

    Selected DOTS entries (see all 49):

    DT.91762257  DT.87042637  DT.121381390  DT.40273529  DT.91762240  DT.100681150  DT.100768038  DT.100681162 
    DT.100857371  DT.86996667  DT.92069518  DT.100681160  DT.121381419  DT.121381453  DT.121381397  DT.40263059 
    DT.92416344  DT.121381443  DT.121381441  DT.121381470  DT.87042635  DT.121381345  DT.121381435  DT.121381482 

    Selected AceView cDNA sequences (see all 643):

    BQ420939 CB528969 BI258903 BX333060 BQ028486 BQ050301 BM762514 AA931558 
    AI702515 AI127527 BU620717 CF128802 CA445490 CR617063 AA431933 AI498121 
    BG388761 AI635263 CK724938 BX090311 BQ019546 BQ932255 BI871337 AI921164 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DAP3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:        -                                                                           
    SP2:                                                                                    


    ECgene alternative splicing isoforms for DAP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGGAAGAC
    DAP3 Expression
    About this image


    DAP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 16) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Ovary (Reproductive System)
             Oviduct
    DAP3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAP3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.516746

    UniProtKB/Swiss-Prot: RT29_HUMAN, P51398
    Tissue specificity: Ubiquitous

        Pathway & Disease-focused RT2 Profiler PCR Array including DAP3: 
              Apoptosis 384HT in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DAP3
    OriGene qSTAR qPCR primer pairs in human, mouse for DAP3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DAP3
    QuantiTect SYBR Green Assays in human, mouse, rat DAP3
    QuantiFast Probe-based Assays in human, mouse, rat DAP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DAP3 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dap31 , 5 death associated protein 31, 5 83.03(n)1
    82.1(a)1
      3 (39.01 cM)5
    651111  NM_022994.31  NP_075370.21 
     889208035 
    chicken
    (Gallus gallus)
    Aves DAP31 death associated protein 3 68.26(n)
    66.75(a)
      425065  XM_004948286.1  XP_004948343.1 
    lizard
    (Anolis carolinensis)
    Reptilia DAP36
    death associated protein 3
    68(a)
    1 ↔ 1
    GL343519.1(357140-363781)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.205202 Xenopus laevis transcribed sequence with weak similarity to protein refNP_387506.1 (H.sapiens) death associated protein 3; mitochondrial ribosomal protein S29; ionizing radiation resistance conferring protein; mitochondrial 28S ribosomal protein S29 [H less 76.82(n)    BQ730824.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.128772 Transcribed sequence with weak similarity to protein refNP_387506.1 (H.sapiens) death associated protein 3; mitochondrial ribosomal protein S29; ionizing radiation resistance conferring protein; mitochondrial 28S ribosomal protein S29 [Homo sapiens] less 75.87(n)    BI880333.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS291 , 3 protein biosynthesis structural
    constituent of ribosome less3
    mitochondrial ribosomal protein S291
    39(a)3
    51.47(n)1
    40.59(a)1
      58E13
    375631  NM_079087.31  NP_523811.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dap-31 , 3 dap-31 33(a)3
    47.24(n)1
    34.71(a)1
      II(10581043-10582315)3
    1746311  NM_063879.51  NP_496280.11 


    ENSEMBL Gene Tree for DAP3 (if available)
    TreeFam Gene Tree for DAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAP3 gene

    Find genes that share paralogs with DAP3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for DAP3
    PGOHUM00000245014 PGOHUM00000241015


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAP3 (see all 1036)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1165593451,2
    C,F--155661006(+) ACTATC/TGAACT 5 -- int11Minor allele frequency- T:0.03WA 118
    rs1919629391,2
    --155661039(+) CAAAAG/TAATCT 5 -- int10--------
    rs1499798101,2
    C--155661086(+) CCTCTC/G/TGCAAC 5 -- int10--------
    rs1832311391,2
    --155661436(+) TACCTG/TTTGAG 5 -- int10--------
    rs1882931541,2
    --155661490(+) CCTAAC/TAGCAA 5 -- int10--------
    rs112644021,2
    C,A,H--155661670(+) ggtggT/Cgacaa 5 -- int12Minor allele frequency- C:0.30NA EA 122
    rs1465545601,2
    --155661719(+) GGAGCC/TAGGGG 5 -- int10--------
    rs1412953671,2
    --155661823(+) CAGGGC/TGAAAC 5 -- int10--------
    rs1437368501,2
    C--155661834(+) AGTCAA/CAGGGA 5 -- int10--------
    rs1911325361,2
    --155661886(+) AGTGAA/CTCTCC 5 -- int10--------

    HapMap Linkage Disequilibrium report for DAP3 (155657751 - 155708801 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DAP3 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2662699CNV Deletion23128226
    esv2421343CNV Deletion20811451
    esv2718429CNV Deletion23290073
    nsv436522CNV Deletion17901297
    nsv3054CNV Loss18451855
    esv28903CNV Loss19812545
    nsv514012CNV Loss21397061
    nsv3065CNV Loss18451855
    esv33869CNV Loss17666407
    nsv428246CNV Gain18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DAP3
    DNA2.0 Custom Variant and Variant Library Synthesis for DAP3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 602074    OMIM disorders: --


    Find genes that share disorders with DAP3           About GenesLikeMe

    2 Novoseek inferred disease relationships for DAP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 9.11 2 9889192 (1)
    tumors 0 2 9889192 (1)

    Genetic Association Database (GAD): DAP3
    Human Genome Epidemiology (HuGE) Navigator: DAP3 (8 documents)

    Export disorders for DAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAP3 gene, integrated from 10 sources (see all 65):
    (articles sorted by number of sources associating them with DAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death. (PubMed id 7499268)1, 2, 3, 9 Kissil J.L....Kimchi A. (J. Biol. Chem. 1995)
    2. Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma. (PubMed id 15179560)1, 4, 9 Hirota T....Tamari M. (J. Hum. Genet. 2004)
    3. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. (PubMed id 19103604)1, 2, 9 Tang T....Farquhar M.G. (J. Biol. Chem. 2009)
    4. A conserved N-terminal sequence targets human DAP3 to mitochondria. (PubMed id 11162496)1, 2, 9 Morgan C.J.... Reynier P. (Biochem. Biophys. Res. Commun. 2001)
    5. Assignment of death associated protein 3 (DAP3) to human chromosome 1q21 by in situ hybridization. (PubMed id 9284927)1, 3, 9 Kissil J.L. and Kimchi A. (Cytogenet. Cell Genet. 1997)
    6. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    7. Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction. (PubMed id 20563667)1, 2 Harada T.... Miyazaki T. (Apoptosis 2010)
    8. Polymorphisms in mitochondrial genes and prostate cancer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (amp 2008)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 7818 HGNC: 2673 AceView: DAP3 Ensembl:ENSG00000132676 euGenes: HUgn7818
    ECgene: DAP3 H-InvDB: DAP3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DAP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DAP3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DAP3 gene:
    Search GeneIP for patents involving DAP3

    Licensable Technologies for DAP3 gene:
    Weizmann Institute:DAP Kinase Gene Family: A Novel Target for Treatment of Neurodegenerative Disorders and Cancer
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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