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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAP3 Gene

protein-coding   GIFtS: 63
GCID: GC01P155657

Death Associated Protein 3

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Death Associated Protein 31 2     MRP-S292 3
Mitochondrial 28S Ribosomal Protein S291 2     MRPS292 3
Death-Associated Protein 32 3     S29mt2 3
Ionizing Radiation Resistance Conferring Protein2 3     28S Ribosomal Protein S29, Mitochondrial2
DAP-32 3     bMRP-102

External Ids:    HGNC: 26731   Entrez Gene: 78182   Ensembl: ENSG000001326767   OMIM: 6020745   UniProtKB: P513983   

Export aliases for DAP3 gene to outside databases

Previous GC identifers: GC01P153522 GC01P151406 GC01P152436 GC01P152875 GC01P152471 GC01P153925 GC01P127020


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DAP3 Gene:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit.
They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is
reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain
a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and
sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a
28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis
factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional
partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct
isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and
2q. (provided by RefSeq, Dec 2010)

GeneCards Summary for DAP3 Gene: 
DAP3 (death associated protein 3) is a protein-coding gene. Diseases associated with DAP3 include thymoma, and burkitt's lymphoma, and among its related super-pathways are TWEAK Pathway and FAS (CD95) signaling pathway. GO annotations related to this gene include protein binding.

UniProtKB/Swiss-Prot: RT29_HUMAN, P51398
Function: Involved in mediating interferon-gamma-induced cell death

Gene Wiki entry for DAP3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAP3 gene promoter:
         GR   GR-alpha   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DAP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

DAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155657:  view genomic region     (about GC identifiers)

Start:
155,657,751 bp from pter      End:
155,708,803 bp from pter
Size:
51,053 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: RT29_HUMAN, P51398 (See protein sequence)
Recommended Name: 28S ribosomal protein S29, mitochondrial precursor  
Size: 398 amino acids; 45566 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30
distinct proteins. Interacts with KIAA0141. Interacts with NOA1
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAA57443.1; Type=Frameshift; Positions=349;
Secondary accessions: B4DP59 B4DY62 E7EM60 Q13044 Q68CT7 Q96Q20
Alternative splicing: 3 isoforms:  P51398-1   P51398-2   P51398-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DAP3: NX_P51398

Explore proteomics data for DAP3 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51398

  • DAP3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DAP3 Protein Expression
    REFSEQ proteins (5 alternative transcripts): 
    NP_001186778.1  NP_001186779.1  NP_001186780.1  NP_004623.1  NP_387506.1  

    ENSEMBL proteins: 
     ENSP00000357320   ENSP00000341692   ENSP00000412605   ENSP00000445003  

    Human Recombinant Protein Products for DAP3: 
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    Novus Biologicals DAP3 Proteins
    Novus Biologicals DAP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DAP3 

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix ----
    GO:0005761mitochondrial ribosome IEA--

    DAP3 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    MRPS: Mitochondrial ribosomal proteins / small subunits

    2 InterPro protein domains:
     IPR008092 Ribosomal_S29_mit
     IPR019368 Ribosomal_S23/S29_mit

    Graphical View of Domain Structure for InterPro Entry P51398

    ProtoNet protein and cluster: P51398

    1 Blocks protein domain: IPB008092 Death associated protein 3 family signature


    DAP3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: RT29_HUMAN, P51398
    Function: Involved in mediating interferon-gamma-induced cell death

         Genatlas biochemistry entry for DAP3:
    death associated protein 3,ubiquitously expressed,involved in mediating interferon gamma induced apoptosis,and as
    well as TNF and TNFRSF6 induced cell death,acting upstream caspases

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19103604
         
    DAP3 for ontologies           About GeneDecksing


    Phenotypes:
         4 GenomeRNAi human phenotypes for DAP3:
     Decreased influenza A/WSN/33 r  Increased G2M DNA content  Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dap3):
     cellular  embryogenesis  growth/size  hematopoietic system  mortality/aging 

    DAP3 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DAP3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DAP3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DAP3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAP3 

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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DAP3:
    hsa-miR-548s hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidDAP3 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DAP3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    TRAIL Pathway0.40
    2TRAIL signaling pathway
    TRAIL signaling pathway0.30
    3all-trans-Retinoic Acid Mediated Apoptosis
    all-trans-Retinoic Acid Mediated Apoptosis

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DAP3
        TRAIL Pathway
    all-trans-Retinoic Acid Mediated Apoptosis

    1 BioSystems Pathway for DAP3
        TRAIL signaling pathway



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/281 Interacting proteins for DAP3 (P513981, 2, 3 ENSP000003416924) via UniProtKB, MINT, STRING, and/or I2D (see all 281)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K92, 3MINT-48164 I2D: score=2 
    NFKB2Q006532, 3MINT-48720 I2D: score=2 
    ICT1Q141972, 3, ENSP000003015854MINT-8079752 MINT-8079764 MINT-8079030 MINT-8079734 I2D: score=1 STRING: ENSP00000301585
    MRPL3P090012MINT-8079752 MINT-8079764 MINT-8079030 MINT-8079734
    NOA1Q8NC601, 2, ENSP000002642304EBI-355912,EBI-717871 MINT-8079030 STRING: ENSP00000264230
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008637apoptotic mitochondrial changes IEA--
    GO:0097190apoptotic signaling pathway TAS7499268

    DAP3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DAP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DAP3 (RT29)

    1 Novoseek inferred chemical compound relationship for DAP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 25.4 1 15908146 (1)

    Search CenterWatch for drugs/clinical trials and news about DAP3 / RT29

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DAP3 gene (5 alternative transcripts): 
    NM_001199849.1  NM_001199850.1  NM_001199851.1  NM_004632.3  NM_033657.2  

    Unigene Cluster for DAP3:

    Death associated protein 3
    Hs.516746  [show with all ESTs]
    Unigene Representative Sequence: NM_001199849
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000461479 ENST00000471642 ENST00000471214 ENST00000479076 ENST00000368336(uc001fls.3 uc001flr.3 uc010pgl.2 uc010pgm.2 uc001flq.3)
    ENST00000343043 ENST00000496863 ENST00000465375 ENST00000462002 ENST00000470830
    ENST00000463575 ENST00000497826 ENST00000471523 ENST00000479151 ENST00000466384
    ENST00000462978 ENST00000477394 ENST00000475056
    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DAP3:
    hsa-miR-548s hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmidDAP3 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector (see all 5): DAP3 (NM_033657)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAP3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAP3

    Additional mRNA sequence: 

    AK225869.1 AK293117.1 AK298201.1 AK302281.1 BC107487.1 BC107488.1 BT019494.1 CR749790.1 
    U18321.1 X83544.1 

    24/49 DOTS entries (see all 49):

    DT.91762257  DT.87042637  DT.121381390  DT.40273529  DT.91762240  DT.100681150  DT.100768038  DT.100681162 
    DT.100857371  DT.86996667  DT.92069518  DT.100681160  DT.121381419  DT.121381453  DT.121381397  DT.40263059 
    DT.92416344  DT.121381443  DT.121381441  DT.121381470  DT.87042635  DT.121381345  DT.121381435  DT.121381482 

    24/643 AceView cDNA sequences (see all 643):

    BM760714 CA446836 BU070625 BM969306 BU619274 BI092591 AA720995 BX336638 
    BI868360 BQ029418 AA338853 AA338852 BU620717 AA970858 BQ183744 BX365145 
    CR595833 N21403 AA789000 BG058521 CB528969 BM700527 BE159230 F12465 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DAP3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:        -                                                                           
    SP2:                                                                                    


    ECgene alternative splicing isoforms for DAP3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAP3 expression in normal human tissues (normalized intensities)      DAP3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGGAAGAC
    DAP3 Expression
    About this image


    DAP3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/2 selected tissues (see all 2) fully expand
     
     Brain (Nervous System)    fully expand to see all 7 entries
             Thalamus
             Olfactory Bulb   
     
     Oral Cavity (Gastrointestinal Tract)
             TONGUE   

     -- (Endocrine System)
             pituitary   

    See DAP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAP3

    SOURCE GeneReport for Unigene cluster: Hs.516746

    UniProtKB/Swiss-Prot: RT29_HUMAN, P51398
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including DAP3: 
              Apoptosis 384HT in human mouse rat

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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAP3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAP3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DAP3 gene from 7/17 species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dap31 , 5 death associated protein 31, 5 83.12(n)1
    82.1(a)1
      3 (39.01 cM)5
    651111  NM_022994.31  NP_075370.21 
     889208035 
    chicken
    (Gallus gallus)
    Aves DAP31 death associated protein 3 68.18(n)
    66.5(a)
      425065  XM_422859.3  XP_422859.2 
    lizard
    (Anolis carolinensis)
    Reptilia DAP36
    Uncharacterized protein
    68(a)
    1 ↔ 1
    GL343519.1(357140-363781)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.205202 Xenopus laevis transcribed sequence with weak similarity to protein refNP_387506.1 (H.sapiens) death associated protein 3; mitochondrial ribosomal protein S29; ionizing radiation resistance conferring protein; mitochondrial 28S ribosomal protein S29 [H less 76.82(n)    BQ730824.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.128772 Transcribed sequence with weak similarity to protein refNP_387506.1 (H.sapiens) death associated protein 3; mitochondrial ribosomal protein S29; ionizing radiation resistance conferring protein; mitochondrial 28S ribosomal protein S29 [Homo sapiens] less 75.87(n)    BI880333.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta mRpS291 , 3 protein biosynthesis structural
    constituent of ribosome less3
    mitochondrial ribosomal protein S291
    39(a)3
    51.09(n)1
    40.48(a)1
      58E13
    375631  NM_079087.31  NP_523811.11 
    worm
    (Caenorhabditis elegans)
    Secernentea dap-31 , 3 Protein DAP-31 33(a)3
    47.24(n)1
    34.71(a)1
      II(10581043-10582315)3
    1746311  NM_063879.41  NP_496280.11 


    ENSEMBL Gene Tree for DAP3 (if available)
    TreeFam Gene Tree for DAP3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DAP3 gene

    DAP3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DAP3
    PGOHUM00000245014 PGOHUM00000241015


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1036 SNPs in DAP3 are shown (see all 1036)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1165593451,2
    C,F--155661006(+) ACTATC/TGAACT 5 -- int11Minor allele frequency- T:0.03WA 118
    rs1919629391,2
    --155661039(+) CAAAAG/TAATCT 5 -- int10--------
    rs1499798101,2
    C--155661086(+) CCTCTC/G/TGCAAC 5 -- int10--------
    rs1832311391,2
    --155661436(+) TACCTG/TTTGAG 5 -- int10--------
    rs1882931541,2
    --155661490(+) CCTAAC/TAGCAA 5 -- int10--------
    rs112644021,2
    C,A,H--155661670(+) ggtggT/Cgacaa 5 -- int12Minor allele frequency- C:0.30NA EA 122
    rs1465545601,2
    --155661719(+) GGAGCC/TAGGGG 5 -- int10--------
    rs1412953671,2
    --155661823(+) CAGGGC/TGAAAC 5 -- int10--------
    rs1437368501,2
    C--155661834(+) AGTCAA/CAGGGA 5 -- int10--------
    rs1911325361,2
    --155661886(+) AGTGAA/CTCTCC 5 -- int10--------

    HapMap Linkage Disequilibrium report for DAP3 (155657751 - 155708803 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/11 variations for DAP3 (see all 11):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2662699CNV Deletion23128226
    esv2421343CNV Deletion20811451
    esv2718429CNV Deletion23290073
    nsv436522CNV Deletion17901297
    nsv3054CNV Loss18451855
    esv28903CNV Loss19812545
    nsv514012CNV Loss21397061
    nsv3065CNV Loss18451855
    esv33869CNV Loss17666407
    nsv428246CNV Gain18775914

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 602074    OMIM disorders: --

    14 diseases for DAP3:    About MalaCards
    thymoma    burkitt's lymphoma    esophageal cancer    acute lymphoblastic leukemia
    lymphoblastic leukemia    osteosarcoma    chronic lymphocytic leukemia    esophagitis
    asthma    glioblastoma    leukemia    thyroiditis
    prostatitis    breast cancer


    DAP3 for disorders           About GeneDecksing

    2 Novoseek inferred disease relationships for DAP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 9.11 2 9889192 (1)
    tumors 0 2 9889192 (1)

    Genetic Association Database (GAD): DAP3
    Human Genome Epidemiology (HuGE) Navigator: DAP3 (8 documents)

    Export disorders for DAP3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAP3 gene, integrated from 9 sources (see all 62):
    (articles sorted by number of sources associating them with DAP3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death. (PubMed id 7499268)1, 2, 3, 9 Kissil J.L....Kimchi A. (1995)
    2. Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma. (PubMed id 15179560)1, 4, 9 Hirota T....Tamari M. (2004)
    3. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. (PubMed id 19103604)1, 2, 9 Tang T....Farquhar M.G. (2009)
    4. A conserved N-terminal sequence targets human DAP3 to mitochondria. (PubMed id 11162496)1, 2, 9 Morgan C.J....Reynier P. (2001)
    5. Assignment of death associated protein 3 (DAP3) to human chromosome 1q21 by in situ hybridization. (PubMed id 9284927)1, 3, 9 Kissil J.L. and Kimchi A. (1997)
    6. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    7. Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction. (PubMed id 20563667)1, 2 Harada T....Miyazaki T. (2010)
    8. Polymorphisms in mitochondrial genes and prostate can cer risk. (PubMed id 19064571)1, 4 Wang L....Thibodeau S.N. (2008)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7818 HGNC: 2673 AceView: DAP3 Ensembl:ENSG00000132676 euGenes: HUgn7818
    ECgene: DAP3 H-InvDB: DAP3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DAP3 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DAP3 gene:
    Search GeneIP for patents involving DAP3

    Licensable Technologies for DAP3 gene:
    Weizmann Institute:DAP Kinase Gene Family: A Novel Target for Treatment of Neurodegenerative Disorders and Cancer
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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