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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAP3 Gene

protein-coding   GIFtS: 60
GCID: GC01P155657

death associated protein 3
 Explore 14 diseases affiliated with
DAP3 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DAP3    

Aliases
for DAP3 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Death Associated Protein 31 2     S29mt2 3
DAP-31 2 3     DKFZp686G121591
MRP-S291 2 3     MGC1260581
MRPS291 2 3     MGC1260591
BMRP-101     28S Ribosomal Protein S29, Mitochondrial2
Death-Associated Protein 32 3     Mitochondrial 28S Ribosomal Protein S292
Ionizing Radiation Resistance Conferring Protein2 3     

External Ids:    HGNC: 26731   Entrez Gene: 78182   Ensembl: ENSG000001326767   OMIM: 6020745   UniProtKB: P513983   

Export aliases for DAP3 gene to outside databases

Previous GC identifers: GC01P153522 GC01P151406 GC01P152436 GC01P152875 GC01P152471 GC01P153925 GC01P127020


Summaries
for DAP3 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DAP3:
Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the
mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They
have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed.
Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA.
Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in
biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein
that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma
interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27.
Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.
Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. (provided by RefSeq, Dec 2010)

UniProtKB/Swiss-Prot: RT29_HUMAN, P51398
Function: Involved in mediating interferon-gamma-induced cell death

Gene Wiki entry for DAP3


Genomic Views
for DAP3 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAP3 gene promoter:
         GR   GR-alpha   YY1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DAP3 promoter sequence
   Search SABiosciences Chromatin IP Primers for DAP3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAP3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q22   Ensembl cytogenetic band:  1q22   HGNC cytogenetic band: 1q22

DAP3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAP3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P155657:  view genomic region     (about GC identifiers)

Start:
 155,657,751 bp from pter      End:
 155,708,803 bp from pter
Size:
 51,053 bases      Orientation:
 plus strand

Proteins
for DAP3 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: RT29_HUMAN, P51398 (See protein sequence)
Recommended Name: 28S ribosomal protein S29, mitochondrial precursor  
Size: 398 amino acids; 45566 Da
Subunit: Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct
proteins. Interacts with KIAA0141. Interacts with NOA1
Subcellular location: Mitochondrion
Sequence caution: Sequence=AAA57443.1; Type=Frameshift; Positions=349;
Secondary accessions: B4DP59 B4DY62 E7EM60 Q13044 Q68CT7 Q96Q20
Alternative splicing: 3 isoforms:  P51398-1   P51398-2   P51398-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DAP3: NX_P51398

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P51398

    • DAP3 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (5 alternative transcripts): 
    NP_001186778.1  NP_001186779.1  NP_001186780.1  NP_004623.1  NP_387506.1  

    ENSEMBL proteins: 
     ENSP00000357320   ENSP00000341692   ENSP00000412605   ENSP00000445003  

    Human Recombinant Protein Products: 
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    Novus Biologicals DAP3 Proteins
    Novus Biologicals DAP3 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DAP3

    Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005739mitochondrion IDA--
    GO:0005759mitochondrial matrix ----
    GO:0005761mitochondrial ribosome IEA--


    DAP3 for ontologies           About GeneDecksing



    DAP3 Antibody Products: 
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    Uscn Antibodies for DAP3
    ThermoFisher Antibodies for DAP3

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    Uscn ELISAs and CLIAs for DAP3

    Protein Domains /
    Families
    for DAP3 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DAP3 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR008092 Ribosomal_S29_mit
     IPR019368 Ribosomal_S23/S29_mit

    Graphical View of Domain Structure for InterPro Entry P51398

    ProtoNet protein and cluster: P51398

    1 Blocks protein family: IPB008092 Death associated protein 3 family signature


    Function
    for DAP3 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: RT29_HUMAN, P51398
    Function: Involved in mediating interferon-gamma-induced cell death

         Genatlas biochemistry entry for DAP3:
    death associated protein 3,ubiquitously expressed,involved in mediating interferon gamma induced apoptosis,and as well
    as TNF and TNFRSF6 induced cell death,acting upstream caspases

    miRNA
    Products:            		 OriGene 3'-UTR Clone (see all 2): DAP3
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAP3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DAP3:
    hsa-miR-548s hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmid: DAP3 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAP3 (see all 7)
    OriGene shRNA RFP: DAP3
    OriGene siRNA: DAP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAP3

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DAP3

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAP3 (see all 5)
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    GenScript: all cDNA clones in your preferred vector (see all 5): DAP3 (NM_033657)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAP3 

    Cell Line
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    Search LifeMap BioReagents cell lines for DAP3

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAP3

    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI19103604


    DAP3 for ontologies           About GeneDecksing


    4 GenomeRNAi human phenotypes for DAP3:
     Decreased influenza A/WSN/33 r  Increased G2M DNA content  Increased cell death HMECs cel  Increased gamma-H2AX phosphory 

    Animal Models:
         5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dap3):
     cellular  embryogenesis  growth/size  hematopoietic system  mortality/aging 

    DAP3 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DAP3 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1all-trans-Retinoic Acid Mediated Apoptosis
    		all-trans-Retinoic Acid Mediated Apoptosis1.00
    2TRAIL signaling pathway
    		TRAIL signaling pathway1.00
    3TWEAK Pathway
    		TRAIL Pathway0.40

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DAP3
        TRAIL Pathway
    all-trans-Retinoic Acid Mediated Apoptosis

    1 BioSystems Pathway for DAP3 
        TRAIL signaling pathway


    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAP3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/267 Interacting proteins for DAP3 (P513981, 2, 3 ENSP000003416924) via UniProtKB, MINT, STRING, and/or I2D (see all 267)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IKBKGQ9Y6K92, 3MINT-48164 I2D: score=2 
    NFKB2Q006532, 3MINT-48720 I2D: score=2 
    ICT1Q141972, 3, ENSP000003015854MINT-8079752 MINT-8079764 MINT-8079030 MINT-8079734 I2D: score=1 STRING: ENSP00000301585
    MRPL3P090012MINT-8079752 MINT-8079764 MINT-8079030 MINT-8079734
    NOA1Q8NC601, 2, ENSP000002642304EBI-355912,EBI-717871 MINT-8079030 STRING: ENSP00000264230
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0008637apoptotic mitochondrial changes IEA--
    GO:0097190apoptotic signaling pathway TAS7499268


    DAP3 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DAP3 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DAP3 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DAP3
    1 Novoseek chemical compound relationship for DAP3 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    gtp 25.4 1 15908146 (1)

    Search CenterWatch for drugs/clinical trials and news about DAP3 / RT29 

    Transcripts
    for DAP3 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DAP3 gene (5 alternative transcripts): 
    NM_001199849.1  NM_001199850.1  NM_001199851.1  NM_004632.3  NM_033657.2  

    Unigene Cluster for DAP3:

    Death associated protein 3
    Hs.516746  [show with all ESTs]
    Unigene Representative Sequence: NM_001199849
    18/25 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 25):
    ENST00000461479 ENST00000471642 ENST00000471214 ENST00000479076 ENST00000368336(uc001fls.3 uc001flr.3 uc010pgl.2 uc010pgm.2 uc001flq.3)
    ENST00000343043 ENST00000496863 ENST00000465375 ENST00000462002 ENST00000470830
    ENST00000497826 ENST00000463575 ENST00000471523 ENST00000479151 ENST00000466384
    ENST00000462978 ENST00000477394 ENST00000475056

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAP3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate DAP3:
    hsa-miR-548s hsa-miR-548aa
    SwitchGear 3'UTR luciferase reporter plasmid: DAP3 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAP3 (see all 7)
    OriGene shRNA RFP: DAP3
    OriGene siRNA: DAP3
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAP3
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAP3 (see all 5)
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    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 5): DAP3 (NM_033657)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAP3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAP3 
    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DAP3
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAP3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAP3

    Additional cDNA sequence: 

    AK225869.1 AK293117.1 AK298201.1 AK302281.1 BC107487.1 BC107488.1 BT019494.1 CR749790.1 
    U18321.1 X83544.1 

    24/49 DOTS entries (see all 49):

    DT.91762257  DT.87042637  DT.121381390  DT.40273529  DT.91762240  DT.100681150  DT.100768038  DT.100681162 
    DT.100857371  DT.86996667  DT.92069518  DT.100681160  DT.121381419  DT.121381453  DT.121381397  DT.40263059 
    DT.92416344  DT.121381443  DT.121381435  DT.121381441  DT.121381470  DT.87042635  DT.121381345  DT.121381482 

    24/643 AceView cDNA sequences (see all 643):

    AA443721 BX365145 AI161244 AI498121 AI921164 AI052314 CD365011 CR617063 
    CR594396 BU620717 BQ932255 AI360964 BI909719 CB528969 BI871337 AI288811 
    AI702515 BI258903 BQ019546 BQ028486 CR624311 AI025888 CR624714 BG389548 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for DAP3    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:        -                                                                           
    SP2:                                                                                    


    ECgene alternative splicing isoforms for DAP3

    Expression
    for DAP3 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAP3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAGGAAGAC

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See DAP3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAP3

    SOURCE GeneReport for Unigene cluster: Hs.516746

    UniProtKB/Swiss-Prot: RT29_HUMAN, P51398
    Tissue specificity: Ubiquitous

        SABiosciences Expression via Pathway-Focused PCR Array including DAP3: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAP3

    Orthologs
    for DAP3 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DAP3 gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dap31 , 5 death associated protein 31, 5 83.12(n)1
    82.1(a)1    		   3 (39.01 cM)5
    651111  NM_022994.31  NP_075370.21 
     889208035 
    chicken
    (Gallus gallus)    		 Aves DAP31 death associated protein 3 68.18(n)
    66.5(a)    		   425065  XM_422859.3  XP_422859.2 
    lizard
    (Anolis carolinensis)    		 Reptilia DAP36
    		 --
    		 68(a)
    		 1 ↔ 1
    		 GL343519.1(357140-363781)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.205202 Xenopus laevis transcribed sequence with weak similarity to protein refNP_387506.1 (H.sapiens) death associated protein 3; mitochondrial ribosomal protein S29; ionizing radiation resistance conferring protein; mitochondrial 28S ribosomal protein S29 [H less 76.82(n)    BQ730824.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.128772 Transcribed sequence with weak similarity to protein refNP_387506.1 (H.sapiens) death associated protein 3; mitochondrial ribosomal protein S29; ionizing radiation resistance conferring protein; mitochondrial 28S ribosomal protein S29 [Homo sapiens] less 75.87(n)    BI880333.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta mRpS291 , 3 protein biosynthesis structural constituent
    of ribosome less3
    mitochondrial ribosomal protein S291    		 39(a)3
    51.09(n)1
    40.48(a)1    		   58E13
    375631  NM_079087.31  NP_523811.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea dap-31 , 3 Protein DAP-31 33(a)3
    47.24(n)1
    34.71(a)1    		   II(10581043-10582315)3
    1746311  NM_063879.41  NP_496280.11 


    ENSEMBL Gene Tree for DAP3 (if available)
    TreeFam Gene Tree for DAP3 (if available) 

    Paralogs
    for DAP3 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DAP3 gene

    DAP3 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for DAP3
    PGOHUM00000245014 PGOHUM00000241015


    Genomic Variants
    for DAP3 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/862 NCBI SNPs in DAP3 are shown (see all 862)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1878622371,2
    		--155656898(+) GAAACC/TGAAAG 16 -- int1 us2k10--------
    rs752567831,2
    		C,--155656942(+) AACCCA/GCGACA 16 -- int1 us2k10--------
    rs1927166491,2
    		--155657804(+) CCCAGG/TATTCA 16 -- int1 us2k10--------
    rs1841331331,2
    		C,--155657841(+) ATGCCG/TGCCCA 16 -- us2k1 int10--------
    rs2011638531,2
    		C,--155657845(+) CGGCCA/CAAATC 16 -- us2k1 int10--------
    rs412649471,2
    		C--155658270(+) ACGTCA/CGCCCG 16 -- int1 ut51 us2k11Minor allele frequency- C:0.01EU 189
    rs6781571,2
    		C,F,A,H,--155658341(-) CTCGCG/AGGACG 16 -- int1 us2k1 ut5110Minor allele frequency- A:0.43NS EA NA CSA WA 784
    rs1891419631,2
    		--155658358(+) ATCCCA/GTACGC 16 -- us2k1 int1 ut510--------
    rs283626351,2
    		C,F,H--155658439(+) AGGCCC/TTCACG 16 -- int1 us2k1 ut513Minor allele frequency- T:0.09NS 682
    rs2002479441,2
    		C--155658501(+) CCCCCC/TCCCTC 16 -- us2k1 ut51 int10--------

    HapMap Linkage Disequilibrium report for DAP3 (155657751 - 155708803 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 15 variations for DAP3
         15 CNVs: 38770 74734 74735 74738 84599 84596 84595 34722 74737 84598 34721 84597 65021 74736 6789

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    Disorders / Diseases
    for DAP3 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DAP3 for disorders           About GeneDecksing

    OMIM gene information: 602074    OMIM disorders: --

    14 diseases for DAP3:    About MalaCards
    acute lymphoblastic leukemia    chronic lymphocytic leukemia    lymphoblastic leukemia    lymphocytic leukemia
    burkitt's lymphoma    thymoma    leukemia    esophageal cancer
    esophagitis    osteosarcoma    asthma    glioblastoma
    thyroiditis    prostatitis

    2 Novoseek disease relationships for DAP3 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 9.11 2 9889192 (1)
    tumors 0 2 9889192 (1)

    Genetic Association Database (GAD): DAP3
    Human Genome Epidemiology (HuGE) Navigator: DAP3 (8 documents)

    Export disorders for DAP3 gene to outside databases

    Publications
    for DAP3 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAP3 gene, integrated from 9 sources (see all 58):
    (articles sorted by number of sources associating them with DAP3)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death. (PubMed id 7499268)1, 2, 3, 9 Kissil J.L....Kimchi A. (1995)
    2. Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma. (PubMed id 15179560)1, 4, 9 Hirota T....Tamari M. (2004)
    3. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. (PubMed id 19103604)1, 2, 9 Tang T....Farquhar M.G. (2009)
    4. A conserved N-terminal sequence targets human DAP3 to mitochondria. (PubMed id 11162496)1, 2, 9 Morgan C.J....Reynier P. (2001)
    5. Assignment of death associated protein 3 (DAP3) to human chromosome 1q21 by in situ hybridization. (PubMed id 9284927)1, 3, 9 Kissil J.L. and Kimchi A. (1997)
    6. Identification of DELE, a novel DAP3-binding protein which is crucial for death receptor-mediated apoptosis induction. (PubMed id 20563667)1, 2 Harada T....Miyazaki T. (2010)
    7. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    8. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    9. The human mitochondrial ribosomal protein genes: mapping of 54 genes to the chromosomes and implications for human disorders. (PubMed id 11543634)1, 2 Kenmochi N....Tanaka T. (2001)
    10. The small subunit of the mammalian mitochondrial ribosome: identification of the full complement of ribosomal proteins present. (PubMed id 11279123)1, 2 Koc E.C.... Spremulli L.L. (2001)

    External Searches for DAP3 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DAP3 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 7818 HGNC: 2673 AceView: DAP3 Ensembl:ENSG00000132676 euGenes: HUgn7818
    ECgene: DAP3 H-InvDB: DAP3

    Other Databases showing DAP3 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DAP3 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAP3 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DAP3 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DAP3 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DAP3 gene:
    Search GeneIP for patents involving DAP3

    Licensable Technologies for DAP3 gene:
    Weizmann Institute:DAP Kinase Gene Family: A Novel Target for Treatment of Neurodegenerative Disorders and Cancer
    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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