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Aliases for DAP3 Gene

Aliases for DAP3 Gene

  • Death Associated Protein 3 2 3
  • Ionizing Radiation Resistance Conferring Protein 3 4
  • Mitochondrial 28S Ribosomal Protein S29 2 3
  • Death-Associated Protein 3 3 4
  • MRP-S29 3 4
  • MRPS29 3 4
  • DAP-3 3 4
  • S29mt 3 4
  • 28S Ribosomal Protein S29, Mitochondrial 3
  • BMRP-10 3

External Ids for DAP3 Gene

Previous GeneCards Identifiers for DAP3 Gene

  • GC01P153522
  • GC01P151406
  • GC01P152436
  • GC01P152875
  • GC01P152471
  • GC01P153925
  • GC01P127020

Summaries for DAP3 Gene

Entrez Gene Summary for DAP3 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]

GeneCards Summary for DAP3 Gene

DAP3 (Death Associated Protein 3) is a Protein Coding gene. Among its related pathways are FAS (CD95) signaling pathway and TWEAK Pathway.

UniProtKB/Swiss-Prot for DAP3 Gene

  • Involved in mediating interferon-gamma-induced cell death

Gene Wiki entry for DAP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAP3 Gene

Genomics for DAP3 Gene

Regulatory Elements for DAP3 Gene

Transcription factor binding sites by QIAGEN in the DAP3 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DAP3 Gene

155,687,960 bp from pter
155,739,010 bp from pter
51,051 bases
Plus strand

Genomic View for DAP3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAP3 Gene

Proteins for DAP3 Gene

  • Protein details for DAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    28S ribosomal protein S29, mitochondrial
    Protein Accession:
    Secondary Accessions:
    • B4DP59
    • B4DY62
    • E7EM60
    • Q13044
    • Q68CT7
    • Q96Q20

    Protein attributes for DAP3 Gene

    398 amino acids
    Molecular mass:
    45566 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with KIAA0141. Interacts with NOA1.
    • Sequence=AAA57443.1; Type=Frameshift; Positions=349; Evidence={ECO:0000305};

    Alternative splice isoforms for DAP3 Gene


neXtProt entry for DAP3 Gene

Proteomics data for DAP3 Gene at MOPED

Post-translational modifications for DAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for DAP3 Gene

Domains for DAP3 Gene

Gene Families for DAP3 Gene

  • MRPS :Mitochondrial ribosomal proteins / small subunits

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DAP3: view

No data available for UniProtKB/Swiss-Prot for DAP3 Gene

Function for DAP3 Gene

Molecular function for DAP3 Gene

GENATLAS Biochemistry:
death associated protein 3,ubiquitously expressed,involved in mediating interferon gamma induced apoptosis,and as well as TNF and TNFRSF6 induced cell death,acting upstream caspases
UniProtKB/Swiss-Prot Function:
Involved in mediating interferon-gamma-induced cell death

Gene Ontology (GO) - Molecular Function for DAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 19103604
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DAP3: view
genes like me logo Genes that share phenotypes with DAP3: view

Animal Model Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAP3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DAP3 Gene

Localization for DAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAP3 Gene


Subcellular locations from

Jensen Localization Image for DAP3 Gene COMPARTMENTS Subcellular localization image for DAP3 gene
Compartment Confidence
mitochondrion 5
nucleus 4

Gene Ontology (GO) - Cellular Components for DAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005730 nucleolus IDA --
GO:0005739 mitochondrion IDA --
GO:0005743 mitochondrial inner membrane TAS --
genes like me logo Genes that share ontologies with DAP3: view

Pathways for DAP3 Gene

genes like me logo Genes that share pathways with DAP3: view

Pathways by source for DAP3 Gene

1 BioSystems pathway for DAP3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process --
GO:0006996 organelle organization TAS --
GO:0008637 apoptotic mitochondrial changes IEA --
GO:0032543 mitochondrial translation TAS --
GO:0070124 mitochondrial translational initiation TAS --
genes like me logo Genes that share ontologies with DAP3: view

Compounds for DAP3 Gene

(1) Novoseek inferred chemical compound relationships for DAP3 Gene

Compound -log(P) Hits PubMed IDs
gtp 25.4 1
genes like me logo Genes that share compounds with DAP3: view

Transcripts for DAP3 Gene

Unigene Clusters for DAP3 Gene

Death associated protein 3:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAP3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -

Relevant External Links for DAP3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DAP3 Gene

mRNA expression in normal human tissues for DAP3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DAP3 Gene

This gene is overexpressed in Bone (24.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DAP3 Gene

SOURCE GeneReport for Unigene cluster for DAP3 Gene Hs.516746

mRNA Expression by UniProt/SwissProt for DAP3 Gene

Tissue specificity: Ubiquitous
genes like me logo Genes that share expressions with DAP3: view

Expression partners for DAP3 Gene

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for DAP3 Gene

Orthologs for DAP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DAP3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DAP3 35
  • 89.84 (n)
  • 87.66 (a)
DAP3 36
  • 88 (a)
(Canis familiaris)
Mammalia DAP3 35
  • 85.5 (n)
  • 84.22 (a)
DAP3 36
  • 78 (a)
(Mus musculus)
Mammalia Dap3 35
  • 83.03 (n)
  • 82.1 (a)
Dap3 16
Dap3 36
  • 81 (a)
(Rattus norvegicus)
Mammalia Dap3 35
  • 82.78 (n)
  • 83.12 (a)
(Monodelphis domestica)
Mammalia DAP3 36
  • 78 (a)
(Ornithorhynchus anatinus)
Mammalia DAP3 36
  • 64 (a)
(Pan troglodytes)
Mammalia DAP3 36
  • 100 (a)
(Gallus gallus)
Aves DAP3 35
  • 68.26 (n)
  • 66.75 (a)
DAP3 36
  • 67 (a)
(Anolis carolinensis)
Reptilia DAP3 36
  • 68 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dap3 35
  • 64.51 (n)
  • 63.2 (a)
Str.16215 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.20520 35
(Danio rerio)
Actinopterygii dap3 35
  • 62.31 (n)
  • 61.36 (a)
Dr.12877 35
dap3 36
  • 56 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1108 35
fruit fly
(Drosophila melanogaster)
Insecta mRpS29 37
  • 39 (a)
mRpS29 35
  • 51.47 (n)
  • 40.59 (a)
mRpS29 36
  • 37 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000890 35
  • 47.4 (n)
  • 38.73 (a)
(Caenorhabditis elegans)
Secernentea dap-3 37
  • 33 (a)
dap-3 35
  • 47.24 (n)
  • 34.71 (a)
dap-3 36
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 36 (a)
Species with no ortholog for DAP3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAP3 Gene

Gene Tree for DAP3 (if available)
Gene Tree for DAP3 (if available)

Paralogs for DAP3 Gene Pseudogenes for DAP3 Gene

genes like me logo Genes that share paralogs with DAP3: view

No data available for Paralogs for DAP3 Gene

Variants for DAP3 Gene

Sequence variations from dbSNP and Humsavar for DAP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs4933 -- 155,729,327(+) GCTCT(A/C/G/T)TGGGG synonymous-codon, reference
rs168342 -- 155,713,021(-) CACAT(A/G)CACAC intron-variant
rs168343 -- 155,710,276(-) ctcca(A/G)cctgg intron-variant
rs171166 -- 155,713,062(-) AAGCC(G/T)TTTTG intron-variant
rs171167 -- 155,711,804(-) tgaag(A/G)ctgca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAP3 Gene

Variant ID Type Subtype PubMed ID
esv33869 CNV Loss 17666407
nsv428246 CNV Gain 18775914
nsv436522 CNV Deletion 17901297
esv2718429 CNV Deletion 23290073
nsv3054 CNV Loss 18451855
esv28903 CNV Loss 19812545
esv2662699 CNV Deletion 23128226
nsv514012 CNV Loss 21397061
esv2421343 CNV Deletion 20811451
nsv442072 CNV CNV 18776908
nsv3065 CNV Loss 18451855

Relevant External Links for DAP3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAP3 Gene

Disorders for DAP3 Gene

(2) Novoseek inferred disease relationships for DAP3 Gene

Disease -log(P) Hits PubMed IDs
necrosis 9.11 1
tumors 0 1

Relevant External Links for DAP3

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with DAP3: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for DAP3 Gene

Publications for DAP3 Gene

  1. Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death. (PMID: 7499268) Kissil J.L. … Kimchi A. (J. Biol. Chem. 1995) 2 3 4 23
  2. Assignment of death associated protein 3 (DAP3) to human chromosome 1q21 by in situ hybridization. (PMID: 9284927) Kissil J.L. … Kimchi A. (Cytogenet. Cell Genet. 1997) 2 3 23
  3. A conserved N-terminal sequence targets human DAP3 to mitochondria. (PMID: 11162496) Morgan C.J. … Reynier P. (Biochem. Biophys. Res. Commun. 2001) 3 4 23
  4. Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma. (PMID: 15179560) Hirota T. … Tamari M. (J. Hum. Genet. 2004) 3 23 48
  5. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. (PMID: 19103604) Tang T. … Farquhar M.G. (J. Biol. Chem. 2009) 3 4 23

Products for DAP3 Gene

Sources for DAP3 Gene

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