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Aliases for DAP3 Gene

Aliases for DAP3 Gene

  • Death Associated Protein 3 2 3 5
  • Ionizing Radiation Resistance Conferring Protein 3 4
  • Mitochondrial 28S Ribosomal Protein S29 2 3
  • Death-Associated Protein 3 3 4
  • MRP-S29 3 4
  • MRPS29 3 4
  • DAP-3 3 4
  • S29mt 3 4
  • 28S Ribosomal Protein S29, Mitochondrial 3
  • BMRP-10 3

External Ids for DAP3 Gene

Previous GeneCards Identifiers for DAP3 Gene

  • GC01P153522
  • GC01P151406
  • GC01P152436
  • GC01P152875
  • GC01P152471
  • GC01P153925
  • GC01P127020

Summaries for DAP3 Gene

Entrez Gene Summary for DAP3 Gene

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that also participates in apoptotic pathways which are initiated by tumor necrosis factor-alpha, Fas ligand, and gamma interferon. This protein potentially binds ATP/GTP and might be a functional partner of the mitoribosomal protein S27. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. Pseudogenes corresponding to this gene are found on chromosomes 1q and 2q. [provided by RefSeq, Dec 2010]

GeneCards Summary for DAP3 Gene

DAP3 (Death Associated Protein 3) is a Protein Coding gene. Among its related pathways are CASP8 activity is inhibited and Mitochondrial translation. GO annotations related to this gene include poly(A) RNA binding.

UniProtKB/Swiss-Prot for DAP3 Gene

  • Involved in mediating interferon-gamma-induced cell death.

Gene Wiki entry for DAP3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAP3 Gene

Genomics for DAP3 Gene

Regulatory Elements for DAP3 Gene

Enhancers for DAP3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around DAP3 on UCSC Golden Path with GeneCards custom track

Promoters for DAP3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the DAP3 gene promoter:

Genomic Location for DAP3 Gene

Chromosome:
1
Start:
155,687,960 bp from pter
End:
155,739,010 bp from pter
Size:
51,051 bases
Orientation:
Plus strand

Genomic View for DAP3 Gene

Genes around DAP3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAP3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAP3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAP3 Gene

Proteins for DAP3 Gene

  • Protein details for DAP3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P51398-RT29_HUMAN
    Recommended name:
    28S ribosomal protein S29, mitochondrial
    Protein Accession:
    P51398
    Secondary Accessions:
    • B4DP59
    • B4DY62
    • E7EM60
    • Q13044
    • Q68CT7
    • Q96Q20

    Protein attributes for DAP3 Gene

    Size:
    398 amino acids
    Molecular mass:
    45566 Da
    Quaternary structure:
    • Component of the mitochondrial ribosome small subunit (28S) which comprises a 12S rRNA and about 30 distinct proteins. Interacts with KIAA0141. Interacts with NOA1.
    SequenceCaution:
    • Sequence=AAA57443.1; Type=Frameshift; Positions=349; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DAP3 Gene

    Alternative splice isoforms for DAP3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAP3 Gene

Post-translational modifications for DAP3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

No data available for DME Specific Peptides for DAP3 Gene

Domains & Families for DAP3 Gene

Gene Families for DAP3 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DAP3: view

No data available for UniProtKB/Swiss-Prot for DAP3 Gene

Function for DAP3 Gene

Molecular function for DAP3 Gene

GENATLAS Biochemistry:
death associated protein 3,ubiquitously expressed,involved in mediating interferon gamma induced apoptosis,and as well as TNF and TNFRSF6 induced cell death,acting upstream caspases
UniProtKB/Swiss-Prot Function:
Involved in mediating interferon-gamma-induced cell death.

Gene Ontology (GO) - Molecular Function for DAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003735 structural constituent of ribosome IBA --
GO:0005515 protein binding IPI 19103604
GO:0044822 poly(A) RNA binding IDA 22658674
genes like me logo Genes that share ontologies with DAP3: view
genes like me logo Genes that share phenotypes with DAP3: view

Animal Model Products

  • Taconic Biosciences Mouse Models for DAP3

CRISPR Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DAP3 Gene

Localization for DAP3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAP3 Gene

Mitochondrion.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAP3 Gene COMPARTMENTS Subcellular localization image for DAP3 gene
Compartment Confidence
mitochondrion 5
nucleus 5

Gene Ontology (GO) - Cellular Components for DAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion IDA 20563667
GO:0005743 mitochondrial inner membrane TAS --
GO:0005763 mitochondrial small ribosomal subunit IBA --
genes like me logo Genes that share ontologies with DAP3: view

Pathways & Interactions for DAP3 Gene

genes like me logo Genes that share pathways with DAP3: view

SIGNOR curated interactions for DAP3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for DAP3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070125 mitochondrial translational elongation TAS --
GO:0070126 mitochondrial translational termination TAS --
GO:0097190 apoptotic signaling pathway TAS 7499268
genes like me logo Genes that share ontologies with DAP3: view

Drugs & Compounds for DAP3 Gene

(1) Additional Compounds for DAP3 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DAP3: view

Transcripts for DAP3 Gene

Unigene Clusters for DAP3 Gene

Death associated protein 3:
Representative Sequences:

CRISPR Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAP3 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: -
SP2:

Relevant External Links for DAP3 Gene

GeneLoc Exon Structure for
DAP3
ECgene alternative splicing isoforms for
DAP3

Expression for DAP3 Gene

mRNA expression in normal human tissues for DAP3 Gene

Protein differential expression in normal tissues from HIPED for DAP3 Gene

This gene is overexpressed in Bone (24.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DAP3 Gene



Protein tissue co-expression partners for DAP3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DAP3 Gene:

DAP3

SOURCE GeneReport for Unigene cluster for DAP3 Gene:

Hs.516746

mRNA Expression by UniProt/SwissProt for DAP3 Gene:

P51398-RT29_HUMAN
Tissue specificity: Ubiquitous.
genes like me logo Genes that share expression patterns with DAP3: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DAP3 Gene

Orthologs for DAP3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DAP3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DAP3 34
  • 89.84 (n)
  • 87.66 (a)
DAP3 35
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAP3 34
  • 85.5 (n)
  • 84.22 (a)
DAP3 35
  • 78 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dap3 34
  • 83.03 (n)
  • 82.1 (a)
Dap3 16
Dap3 35
  • 81 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dap3 34
  • 82.78 (n)
  • 83.12 (a)
oppossum
(Monodelphis domestica)
Mammalia DAP3 35
  • 78 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAP3 35
  • 64 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DAP3 35
  • 100 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAP3 34
  • 68.26 (n)
  • 66.75 (a)
DAP3 35
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DAP3 35
  • 68 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dap3 34
  • 64.51 (n)
  • 63.2 (a)
Str.16215 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.20520 34
zebrafish
(Danio rerio)
Actinopterygii dap3 34
  • 62.31 (n)
  • 61.36 (a)
Dr.12877 34
dap3 35
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.1108 34
fruit fly
(Drosophila melanogaster)
Insecta mRpS29 36
  • 39 (a)
mRpS29 34
  • 51.47 (n)
  • 40.59 (a)
mRpS29 35
  • 37 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000890 34
  • 47.4 (n)
  • 38.73 (a)
worm
(Caenorhabditis elegans)
Secernentea dap-3 36
  • 33 (a)
dap-3 34
  • 47.24 (n)
  • 34.71 (a)
dap-3 35
  • 31 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToOne
Species where no ortholog for DAP3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAP3 Gene

ENSEMBL:
Gene Tree for DAP3 (if available)
TreeFam:
Gene Tree for DAP3 (if available)

Paralogs for DAP3 Gene

Pseudogenes.org Pseudogenes for DAP3 Gene

genes like me logo Genes that share paralogs with DAP3: view

No data available for Paralogs for DAP3 Gene

Variants for DAP3 Gene

Sequence variations from dbSNP and Humsavar for DAP3 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs57692591 - 155,729,241(+) ATGCA(G/T)TTGGA reference, missense
rs4933 -- 155,729,327(+) GCTCT(A/C/G/T)TGGGG reference, synonymous-codon
rs168342 -- 155,713,021(-) CACAT(A/G)CACAC intron-variant
rs168343 -- 155,710,276(-) ctcca(A/G)cctgg intron-variant
rs171166 -- 155,713,062(-) AAGCC(G/T)TTTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAP3 Gene

Variant ID Type Subtype PubMed ID
esv2421343 CNV deletion 20811451
esv2662699 CNV deletion 23128226
esv2718429 CNV deletion 23290073
esv28903 CNV loss 19812545
esv33869 CNV loss 17666407
esv3578199 CNV loss 25503493
esv3587627 CNV loss 21293372
esv3587628 CNV gain 21293372
esv3587631 CNV loss 21293372
esv3587632 CNV loss 21293372
nsv1161728 OTHER complex 26073780
nsv3054 CNV deletion 18451855
nsv3065 CNV deletion 18451855
nsv428246 CNV gain 18775914
nsv436522 CNV deletion 17901297
nsv442072 CNV loss 18776908
nsv472921 CNV novel sequence insertion 20440878
nsv514012 CNV loss 21397061
nsv547965 CNV gain 21841781
nsv547966 CNV loss 21841781
nsv946421 CNV duplication 23825009

Variation tolerance for DAP3 Gene

Residual Variation Intolerance Score: 40.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.23; 52.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAP3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAP3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAP3 Gene

Disorders for DAP3 Gene

Relevant External Links for DAP3

Genetic Association Database (GAD)
DAP3
Human Genome Epidemiology (HuGE) Navigator
DAP3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAP3

No disorders were found for DAP3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DAP3 Gene

Publications for DAP3 Gene

  1. Isolation of DAP3, a novel mediator of interferon-gamma-induced cell death. (PMID: 7499268) Kissil J.L. … Kimchi A. (J. Biol. Chem. 1995) 2 3 4 22 65
  2. hNOA1 interacts with complex I and DAP3 and regulates mitochondrial respiration and apoptosis. (PMID: 19103604) Tang T. … Farquhar M.G. (J. Biol. Chem. 2009) 3 4 22 65
  3. Association between genetic variation in the gene for death-associated protein-3 (DAP3) and adult asthma. (PMID: 15179560) Hirota T. … Tamari M. (J. Hum. Genet. 2004) 3 22 46 65
  4. A conserved N-terminal sequence targets human DAP3 to mitochondria. (PMID: 11162496) Morgan C.J. … Reynier P. (Biochem. Biophys. Res. Commun. 2001) 3 4 22 65
  5. Assignment of death associated protein 3 (DAP3) to human chromosome 1q21 by in situ hybridization. (PMID: 9284927) Kissil J.L. … Kimchi A. (Cytogenet. Cell Genet. 1997) 2 3 22 65

Products for DAP3 Gene

Sources for DAP3 Gene

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