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DAP Gene

protein-coding   GIFtS: 58
GCID: GC05M010679

Death-Associated Protein

  Search for DAP
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Death-Associated Protein1 2
DAP-12 3
Death-Associated Protein 12
DAP13

External Ids:    HGNC: 26721   Entrez Gene: 16112   Ensembl: ENSG000001129777   OMIM: 6009545   UniProtKB: P513973   

Export aliases for DAP gene to outside databases

Previous GC identifers: GC05M010790 GC05M010732


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAP Gene:
This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell
death that is induced by interferon-gamma. (provided by RefSeq, Jul 2008)

GeneCards Summary for DAP Gene:
DAP (death-associated protein) is a protein-coding gene. GO annotations related to this gene include death domain binding.

UniProtKB/Swiss-Prot: DAP1_HUMAN, P51397
Function: Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death

Gene Wiki entry for DAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000005.9  NC_018916.2  NT_006576.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAP gene promoter:
         Nkx3-1   Nkx3-1 v4   p53   Nkx3-1 v1   Tal-1beta   LCR-F1   Nkx3-1 v2   Nkx3-1 v3   Sox9   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DAP promoter sequence
   Search Chromatin IP Primers for DAP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.2   Ensembl cytogenetic band:  5p15.2   HGNC cytogenetic band: 5p15.2

DAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M010679:  view genomic region     (about GC identifiers)

Start:
10,679,342 bp from pter      End:
10,761,387 bp from pter
Size:
82,046 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DAP1_HUMAN, P51397 (See protein sequence)
Recommended Name: Death-associated protein 1  
Size: 102 amino acids; 11165 Da
Secondary accessions: Q6FGC3 Q9BUC9

Explore the universe of human proteins at neXtProt for DAP: NX_P51397

Explore proteomics data for DAP at MOPED

Post-translational modifications: 

  • Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy1
  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DAP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004385.1  
    ENSEMBL proteins: 
     ENSP00000230895   ENSP00000394163  

    DAP Human Recombinant Protein Products:

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    Cloud-Clone Corp. Proteins for DAP

     
    Search eBioscience for Proteins for DAP 

    DAP Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DAP
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    DAP Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DAP
    Cloud-Clone Corp. CLIAs for DAP
    Search eBioscience for ELISAs for DAP 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR024130 DAP1/DAPL1

    Graphical View of Domain Structure for InterPro Entry P51397

    ProtoNet protein and cluster: P51397


    Find genes that share domains with DAP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAP1_HUMAN, P51397
    Function: Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death

         Genatlas biochemistry entry for DAP:
    positive mediator of apoptosis,15kDa,triggered by interferon gamma,death associated protein 1

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070513death domain binding IPI1087798
         
    Find genes that share ontologies with DAP           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DAP
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DAP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DAP
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAP

    miRNA
    Products:
        
    miRTarBase miRNAs that target DAP:
    hsa-mir-335-5p (MIRT018510), hsa-mir-183-5p (MIRT005726)

    Block miRNA regulation of human, mouse, rat DAP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAP (see all 9):
    hsa-miR-3910 hsa-miR-206 hsa-miR-1 hsa-miR-1184 hsa-miR-124 hsa-miR-550b hsa-miR-506 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidDAP 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DAP
    Predesigned siRNA for gene silencing in human, mouse, rat DAP

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DAP

    Clone
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    OriGene clones in human, mouse for DAP (see all 6)
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    GenScript: all cDNA clones in your preferred vector: DAP (NM_004394)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAP

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAP


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    mitochondrion1
    vacuole1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAP About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    MIF Regulation of Innate Immune Cells0.94
    RAR-Gamma-RXR-Alpha Degradation0.62
    MIF Mediated Glucocorticoid Regulation0.94
    IL-6 Pathway0.61
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2ERK Signaling
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    3Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    4PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway


    Find genes that share SuperPaths with DAP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DAP (see all 15)
        MIF Regulation of Innate Immune Cells
    STAT3 Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for DAP
        Apoptosis and Autophagy

    1 BioSystems Pathway for DAP
        TNF-alpha/NF-kB Signaling Pathway



        Pathway & Disease-focused RT2 Profiler PCR Array including DAP: 
              Apoptosis 384HT in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    Selected Interacting proteins for DAP (P513973 ENSP000002308954) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SETDB1Q150473I2D: score=4 
    MTORP423453I2D: score=1 
    TNFRSF1AP194383I2D: score=1 
    KRT33AENSP000000077354STRING: ENSP00000007735
    KIF4AENSP000003635244STRING: ENSP00000363524
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0006915apoptotic process IGI7828849
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IMP1087798
    GO:0010507negative regulation of autophagy IMP--
    GO:0032088negative regulation of NF-kappaB transcription factor activity IMP1087798

    Find genes that share ontologies with DAP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAP (DAP1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DAP gene: 
    NM_004394.2  

    Unigene Cluster for DAP:

    Death-associated protein
    Hs.75189  [show with all ESTs]
    Unigene Representative Sequence: NM_004394
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000230895(uc003jez.4 uc011cmw.2) ENST00000432074 ENST00000514882
    ENST00000508253 ENST00000510546 ENST00000508646
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DAP using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAP (see all 9):
    hsa-miR-3910 hsa-miR-206 hsa-miR-1 hsa-miR-1184 hsa-miR-124 hsa-miR-550b hsa-miR-506 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidDAP 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for DAP
    Predesigned siRNA for gene silencing in human, mouse, rat DAP
    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DAP (NM_004394)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAP
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DAP
    OriGene qSTAR qPCR primer pairs in human, mouse for DAP
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DAP
      QuantiTect SYBR Green Assays in human, mouse, rat DAP
      QuantiFast Probe-based Assays in human, mouse, rat DAP

    Additional mRNA sequence: 

    AF056450.1 AK298670.1 AK311783.1 BC002726.2 BT006925.1 CR542184.1 X76105.1 

    18 DOTS entries:

    DT.100848796  DT.97786156  DT.75121046  DT.99982408  DT.100848786  DT.100848795  DT.100848787  DT.92449320 
    DT.100848785  DT.95372900  DT.100640726  DT.100848789  DT.92449311  DT.92449318  DT.95372894  DT.99942273 
    DT.100800411  DT.100848780 

    Selected AceView cDNA sequences (see all 692):

    BC002726 CF131214 BQ010174 AI936818 CR607455 BM976833 BE880443 AA452931 
    BG121970 AI076261 BQ278819 BF969486 AA588036 BE328688 BM982452 AA992573 
    AI222790 CA422913 AI951448 AL120966 BI966875 AA292056 BI762556 BF589455 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCTGTGAG
    DAP Expression
    About this image


    DAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 18) fully expand
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Nucleus Pulposus
             Nucleus Pulposus
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived endothelial progenitor cells
     
     Primitive Streak (Early Embryonic Tissues)
             Notochord
     
     Bone (Muscoskeletal System)
             Rib
     
     Colon (Gastrointestinal Tract)
    DAP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.75189
        Pathway & Disease-focused RT2 Profiler PCR Array including DAP: 
              Apoptosis 384HT in human mouse rat

    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat DAP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DAP gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dap1 , 5 death-associated protein1, 5 86.6(n)1
    96.08(a)1
      15 (12.67 cM)5
    2234531  NM_146057.31  NP_666169.11 
     312243855 
    chicken
    (Gallus gallus)
    Aves DAP1 death-associated protein 79.74(n)
    83.33(a)
      420923  NM_001031003.1  NP_001026174.1 
    lizard
    (Anolis carolinensis)
    Reptilia DAP6
    death-associated protein
    78(a)
    1 ↔ 1
    4(66392943-66465473)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.135812 Xenopus laevis, Similar to death-associated protein, more 77.47(n)    BC044126.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC049052.12   -- 74.67(n)   58093  BC049052.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG123846
    --
    44(a)
    1 ↔ 1
    2R(7245407-7246674)


    ENSEMBL Gene Tree for DAP (if available)
    TreeFam Gene Tree for DAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAP gene
    1 SIMAP similar gene for DAP using alignment to 3 protein entries:     DAP1_HUMAN (see all proteins):
    DAPL1

    Find genes that share paralogs with DAP           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAP (see all 1909)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894208251,2
    --10637226(+) TGGATG/TGCCAG 1 -- ds50010--------
    rs168851261,2
    C,F,H--10637449(+) CTGACA/GTTTTA 1 -- ds50017Minor allele frequency- G:0.00NA NS EA 560
    rs1810706591,2
    C--10637559(+) CTACTA/GAAACC 1 -- ds50010--------
    rs1170299711,2
    C,F--10637725(+) CTAAAG/CCTCAC 1 -- ut311Minor allele frequency- C:0.03EA 120
    rs57453051,2
    C--10637726(-) TGTGAG/ACTTTA 1 -- ut312Minor allele frequency- A:0.01NS NA 180
    rs587651261,2
    C--10637737(+) GATGC-/ATGCCA 1 -- ut310--------
    rs1844944681,2
    --10637761(+) GTACAC/TAAAAA 1 -- ut310--------
    rs1902425511,2
    --10637802(+) TGGCTA/GAAGAC 1 -- ut310--------
    rs57453041,2
    C,F,H--10637916(-) CCTTTC/TGGAGC 1 -- ut31 ese35Minor allele frequency- T:0.02NS EA 522
    rs79731,2
    C,F,A,H--10638028(-) CTGTCA/GCCACC 1 -- ut31 ese314Minor allele frequency- G:0.13NS MN EA NA CSA 2008

    HapMap Linkage Disequilibrium report for DAP (10679342 - 10761387 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DAP (see all 12):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2664774CNV Deletion23128226
    esv2464339CNV Deletion19546169
    esv2312126CNV Deletion18987734
    esv2729747CNV Deletion23290073
    esv2729746CNV Deletion23290073
    nsv819968CNV Loss19587683
    nsv521304CNV Loss19592680
    esv24449CNV Loss19812545
    esv22939CNV Loss19812545
    esv23832CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DAP
    DNA2.0 Custom Variant and Variant Library Synthesis for DAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 600954    OMIM disorders: --


    Find genes that share disorders with DAP           About GenesLikeMe

    Genetic Association Database (GAD): DAP
    Human Genome Epidemiology (HuGE) Navigator: DAP (30 documents)

    Export disorders for DAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAP gene, integrated from 10 sources (see all 31):
    (articles sorted by number of sources associating them with DAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. (PubMed id 7828849)1, 2, 3, 9 Deiss L.P.... Kimchi A. (Genes Dev. 1995)
    2. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (Nat. Genet. 2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    4. DAP1, a novel substrate of mTOR, negatively regulates autophagy. (PubMed id 20537536)1, 2 Koren I.... Kimchi A. (Curr. Biol. 2010)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins. (PubMed id 16602700)1, 2 Zougman A. and Wisniewski J.R. (J. Proteome Res. 2006)
    7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    8. Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively. (PubMed id 8530096)1, 3 Feinstein E....Huebner K. (Genomics 1995)
    9. Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions. (PubMed id 9916995)1, 9 Levy-Strumpf N. and Kimchi A. (Oncogene 1998)
    10. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1611 HGNC: 2672 AceView: DAP Ensembl:ENSG00000112977 euGenes: HUgn1611
    ECgene: DAP H-InvDB: DAP

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DAP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DAP Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/dap/

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