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Aliases for DAP Gene

Aliases for DAP Gene

  • Death-Associated Protein 2 3
  • DAP-1 3 4
  • Death-Associated Protein 1 3
  • DAP1 4

External Ids for DAP Gene

Previous GeneCards Identifiers for DAP Gene

  • GC05M010790
  • GC05M010732

Summaries for DAP Gene

Entrez Gene Summary for DAP Gene

  • This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell death that is induced by interferon-gamma. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

GeneCards Summary for DAP Gene

DAP (Death-Associated Protein) is a Protein Coding gene. Among its related pathways are Akt Signaling and Akt Signaling. GO annotations related to this gene include death domain binding.

UniProtKB/Swiss-Prot for DAP Gene

  • Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.

Gene Wiki entry for DAP Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAP Gene

Genomics for DAP Gene

Regulatory Elements for DAP Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DAP Gene

10,679,230 bp from pter
10,761,275 bp from pter
82,046 bases
Minus strand

Genomic View for DAP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAP Gene

Proteins for DAP Gene

  • Protein details for DAP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Death-associated protein 1
    Protein Accession:
    Secondary Accessions:
    • Q6FGC3
    • Q9BUC9

    Protein attributes for DAP Gene

    102 amino acids
    Molecular mass:
    11165 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DAP Gene

Proteomics data for DAP Gene at MOPED

Post-translational modifications for DAP Gene

  • Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAP Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DAP (DAP)

No data available for DME Specific Peptides for DAP Gene

Domains for DAP Gene

Protein Domains for DAP Gene


Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DAP: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DAP Gene

Function for DAP Gene

Molecular function for DAP Gene

GENATLAS Biochemistry:
positive mediator of apoptosis,15kDa,triggered by interferon gamma,death associated protein 1
UniProtKB/Swiss-Prot Function:
Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death.

Gene Ontology (GO) - Molecular Function for DAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070513 death domain binding IPI 1087798
genes like me logo Genes that share ontologies with DAP: view

miRNA for DAP Gene

miRTarBase miRNAs that target DAP

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for DAP Gene

Localization for DAP Gene

Subcellular locations from

Jensen Localization Image for DAP Gene COMPARTMENTS Subcellular localization image for DAP gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1
vacuole 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DAP Gene

Pathways for DAP Gene

genes like me logo Genes that share pathways with DAP: view

Pathways by source for DAP Gene

1 Cell Signaling Technology pathway for DAP Gene
1 BioSystems pathway for DAP Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DAP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006914 autophagy IEA --
GO:0006915 apoptotic process IGI 7828849
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IMP 1087798
GO:0010507 negative regulation of autophagy IMP 20537536
GO:0032088 negative regulation of NF-kappaB transcription factor activity IMP 1087798
genes like me logo Genes that share ontologies with DAP: view

Transcripts for DAP Gene

Unigene Clusters for DAP Gene

Death-associated protein:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAP

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAP Gene

No ASD Table

Relevant External Links for DAP Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DAP Gene

mRNA expression in normal human tissues for DAP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues for DAP Gene

This gene is overexpressed in Skin (16.0), Stomach (14.6), and Peripheral blood mononuclear cells (9.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DAP Gene

SOURCE GeneReport for Unigene cluster for DAP Gene Hs.75189

genes like me logo Genes that share expressions with DAP: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Expression partners for DAP Gene

Orthologs for DAP Gene

This gene was present in the common ancestor of animals.

Orthologs for DAP Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DAP 35
  • 88.56 (n)
  • 96.08 (a)
DAP 36
  • 96 (a)
(Canis familiaris)
Mammalia DAP 35
  • 88.56 (n)
  • 97.06 (a)
(Mus musculus)
Mammalia Dap 35
  • 86.6 (n)
  • 96.08 (a)
Dap 16
Dap 36
  • 96 (a)
(Pan troglodytes)
Mammalia DAP 35
  • 99.02 (n)
  • 98.04 (a)
(Rattus norvegicus)
Mammalia Dap 35
  • 85.62 (n)
  • 92.16 (a)
(Monodelphis domestica)
Mammalia DAP 36
  • 85 (a)
(Ornithorhynchus anatinus)
Mammalia DAP 36
  • 89 (a)
(Gallus gallus)
Aves DAP 35
  • 79.74 (n)
  • 83.33 (a)
DAP 36
  • 81 (a)
(Anolis carolinensis)
Reptilia DAP 36
  • 78 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dap 35
  • 72.55 (n)
  • 72.55 (a)
Str.15389 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.13581 35
(Danio rerio)
Actinopterygii -- 35
dap 35
  • 63.4 (n)
  • 62.75 (a)
dap 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12384 36
  • 44 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.826 36
  • 44 (a)
Species with no ortholog for DAP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DAP Gene

Gene Tree for DAP (if available)
Gene Tree for DAP (if available)

Paralogs for DAP Gene

(1) SIMAP similar genes for DAP Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DAP: view

No data available for Paralogs for DAP Gene

Variants for DAP Gene

Sequence variations from dbSNP and Humsavar for DAP Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs7973 -- 10,679,634(-) CTGTC(A/G)CCACC utr-variant-3-prime
rs9857 -- 10,680,435(+) TTCTT(C/T)GGCAT utr-variant-3-prime
rs10271 -- 10,680,637(-) AATCT(C/T)AACAC utr-variant-3-prime
rs60701 -- 10,733,664(+) AAACA(C/T)CTGCC intron-variant
rs93417 -- 10,731,085(-) TCAGT(A/C)CAGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAP Gene

Variant ID Type Subtype PubMed ID
nsv880520 CNV Gain 21882294
esv24449 CNV Loss 19812545
esv23832 CNV Gain 19812545
nsv521304 CNV Loss 19592680
nsv518038 CNV Gain 19592680
esv2464339 CNV Deletion 19546169
esv2312126 CNV Deletion 18987734
esv2729746 CNV Deletion 23290073
nsv819968 CNV Loss 19587683
esv2664774 CNV Deletion 23128226
esv2729747 CNV Deletion 23290073
esv22939 CNV Loss 19812545

Relevant External Links for DAP Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAP Gene

Disorders for DAP Gene

Relevant External Links for DAP

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator

No disorders were found for DAP Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DAP Gene

Publications for DAP Gene

  1. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. (PMID: 7828849) Deiss L.P. … Kimchi A. (Genes Dev. 1995) 2 3 4 23
  2. Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions. (PMID: 9916995) Levy-Strumpf N. … Kimchi A. (Oncogene 1998) 3 23
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  4. DAP1, a novel substrate of mTOR, negatively regulates autophagy. (PMID: 20537536) Koren I. … Kimchi A. (Curr. Biol. 2010) 3 4
  5. Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47. (PMID: 21297633) Anderson C.A. … Rioux J.D. (Nat. Genet. 2011) 3 48

Products for DAP Gene

Sources for DAP Gene

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