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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DAP Gene

protein-coding GIFtS: 57
GCID: GC05M010679

death-associated protein

Explore 4 diseases affiliated with
DAP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Death-Associated Protein¹ ²
DAP-1² ³
Death-Associated Protein 1²
DAP1³

External Ids:	HGNC: 2672¹	Entrez Gene: 1611²	Ensembl: ENSG00000112977⁷	OMIM: 600954⁵	UniProtKB: P51397³

Export aliases for DAP gene to outside databases

Previous GC identifers: GC05M010790 GC05M010732

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DAP:

This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell

death that is induced by interferon-gamma. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DAP1_HUMAN, P51397

Function: Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death

Gene Wiki entry for DAP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006576.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DAP gene promoter:
Nkx3-1 Nkx3-1 v4 p53 Nkx3-1 v1 Tal-1beta LCR-F1 Nkx3-1 v2 Nkx3-1 v3 Sox9 ITF-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DAP promoter sequence

Search SABiosciences Chromatin IP Primers for DAP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.2 Ensembl cytogenetic band: 5p15.2 HGNC cytogenetic band: 5p15.2

DAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAP gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M010679: view genomic region (about GC identifiers)

Start:	10,679,342 bp from pter	End:	10,761,387 bp from pter
Size:	82,046 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DAP1_HUMAN, P51397 (See protein sequence)

Recommended Name: Death-associated protein 1

Size: 102 amino acids; 11165 Da

Secondary accessions: Q6FGC3 Q9BUC9

Explore the universe of human proteins at neXtProt for DAP: NX_P51397

Post-translational modifications:

Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P51397

DAP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004385.1

ENSEMBL proteins:

ENSP00000230895 ENSP00000394163

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: DAP OriGene Protein Over-expression Lysate: DAP OriGene Custom Protein Services for DAP
	GenScript Custom Purified and Recombinant Proteins Services for DAP
	Novus Biologicals DAP Protein Novus Biologicals DAP Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DAP

DAP Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of DAP
	Browse R&D Systems for Antibodies
	Cell Signaling Technology (CST) Antibodies for DAP
	OriGene Antibodies: DAP OriGene Custom Antibody Services for DAP
	GenScript Superior Antibodies for DAP
	Novus Biologicals DAP Antibodies
	Abcam antibodies for DAP
	Uscn Antibodies for DAP
	ThermoFisher Antibodies for DAP

Assay Products for DAP:

	EMD Millipore Kits and Assays for the Analysis of DAP
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for DAP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for DAP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DAP for domains About GeneDecksing

1 InterPro domain/family:

IPR024130 DAP1/DAPL1

Graphical View of Domain Structure for InterPro Entry P51397

ProtoNet protein and cluster: P51397

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DAP1_HUMAN, P51397

Function: Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death

Genatlas biochemistry entry for DAP:

positive mediator of apoptosis,15kDa,triggered by interferon gamma,death associated protein 1

miRNA Products:		miRTarBase miRNAs that target DAP: hsa-mir-183 (MIRT005726)

		OriGene 3'-UTR Clone: DAP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAP
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate DAP (see all 9):
		hsa-miR-3910 hsa-miR-206 hsa-miR-1 hsa-miR-1184 hsa-miR-124 hsa-miR-550b hsa-miR-506 hsa-miR-613

		SwitchGear 3'UTR luciferase reporter plasmid: DAP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAP (see all 7) OriGene shRNA RFP: DAP OriGene siRNA: DAP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAP

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for DAP

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DAP OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DAP (NM_004394)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DAP
		Search LifeMap BioReagents cell lines for DAP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAP

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0070513	death domain binding	IPI	1087798

DAP for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/6 super-pathways (see all 6) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

PEDF Induced Signaling

PEDF Induced Signaling	1.00	all-trans-Retinoic Acid Signaling in Brain	0.59
MIF Mediated Glucocorticoid Regulation	0.73	RAR-Gamma-RXR-Alpha Degradation	0.54
MIF Regulation of Innate Immune Cells	0.71	STAT3 Pathway	0.47
IL-6 Pathway	0.61	Endothelin-1 Signaling Pathway	0.44

Rho Family GTPases

	Rho Family GTPases	1.00			Molecular Mechanisms of Cancer	0.51
	ERK Signaling	0.61

PAK Pathway

PAK Pathway

1.00

Antioxidant Action of Vitamin-C

0.56

Akt Signaling

Akt Signaling

1.00

p38 Signaling

0.60

Apoptosis and Autophagy

Apoptosis and Autophagy

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DAP (see all 15)

	MIF Regulation of Innate Immune Cells
	STAT3 Pathway
	Endothelin-1 Signaling Pathway
	Molecular Mechanisms of Cancer
	Antioxidant Action of Vitamin-C

1 Cell Signaling Technology (CST) Pathway for DAP

Apoptosis and Autophagy

1 BioSystems Pathway for DAP

TNF-alpha/NF-kB Signaling Pathway

DAP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DAP

STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

5/13 Interacting proteins for DAP (P51397³ ENSP00000230895⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 13)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
SETDB1	Q15047³	I2D: score=4
MTOR	P42345³	I2D: score=1
TNFRSF1A	P19438³	I2D: score=1
KRT33A	ENSP00000007735⁴	STRING: ENSP00000007735
KIF4A	ENSP00000363524⁴	STRING: ENSP00000363524

About this table

Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006914	autophagy	IEA	--
GO:0006915	apoptotic process	IGI	7828849
GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	IMP	1087798
GO:0010507	negative regulation of autophagy	IMP	--
GO:0032088	negative regulation of NF-kappaB transcription factor activity	IMP	1087798

DAP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DAP
Search CenterWatch for drugs/clinical trials and news about DAP / DAP1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DAP gene:

NM_004394.2

Unigene Cluster for DAP:

Death-associated protein

Hs.75189 [show with all ESTs]

Unigene Representative Sequence: NM_004394

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000230895(uc003jez.4 uc011cmw.2) ENST00000432074 ENST00000514882

ENST00000508253 ENST00000510546 ENST00000508646

miRNA Products:		OriGene 3'-UTR Clone: DAP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAP
		8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate DAP (see all 9):
		hsa-miR-3910 hsa-miR-206 hsa-miR-1 hsa-miR-1184 hsa-miR-124 hsa-miR-550b hsa-miR-506 hsa-miR-613

		SwitchGear 3'UTR luciferase reporter plasmid: DAP 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAP (see all 7) OriGene shRNA RFP: DAP OriGene siRNA: DAP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAP

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAP (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DAP OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DAP (NM_004394)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAP
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DAP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DAP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAP

Additional cDNA sequence:

AF056450.1 AK298670.1 AK311783.1 BC002726.2 BT006925.1 CR542184.1 X76105.1

18 DOTS entries:

DT.100848796 DT.97786156 DT.75121046 DT.99982408 DT.100848786 DT.100848795 DT.100848787 DT.92449320

DT.100848785 DT.95372900 DT.100640726 DT.100848789 DT.92449311 DT.92449318 DT.95372894 DT.99942273

DT.100800411 DT.100848780

24/692 AceView cDNA sequences (see all 692):

AI928579 AA223229 AA729859 AA393278 BU542579 BE389087 CK903644 BE465596

BX355779 AI884944 BQ671764 BI090726 AI076261 BQ669882 CR607145 CF131214

BF589455 BQ010174 BG120072 BU623943 BM761744 BU619674 CB163602 CA415699

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DAP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CATCTGTGAG

About this image

DAP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Cartilage

Lumbar Intervertebral Disc

Intervertebral Disc Nucleus Pulposus Cells

Cartilage

Bone

Primitive Streak

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See DAP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DAP

SOURCE GeneReport for Unigene cluster: Hs.75189

SABiosciences Expression via Pathway-Focused PCR Array including DAP:

Apoptosis 384HT in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DAP Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat DAP
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAP

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DAP gene from 6/18 species (see all 18) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Dap^{1 , 5}	death-associated protein^{1, 5}	86.6(n)¹ 96.08(a)¹		15 (12.67 cM)⁵ 223453¹ NM_146057.3¹ NP_666169.1¹ 31224385⁵
chicken (Gallus gallus)	Aves	DAP¹	death-associated protein	79.74(n) 83.33(a)		420923 NM_001031003.1 NP_001026174.1
lizard (Anolis carolinensis)	Reptilia	DAP⁶	--	78(a)	1 ↔ 1	4(66393790-66463816)
African clawed frog (Xenopus laevis)	Amphibia	Xl.13581²	Xenopus laevis, Similar to death-associated protein, more	77.47(n)		BC044126.1
zebrafish (Danio rerio)	Actinopterygii	BC049052.1²	--	74.67(n)		58093 BC049052.1
fruit fly (Drosophila melanogaster)	Insecta	CG12384⁶	--	46(a)	1 ↔ 1	2R(7245407-7246674)

ENSEMBL Gene Tree for DAP (if available)
TreeFam Gene Tree for DAP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs16885126^1,2	C,F,H,	--	10662519(+)	`CTGACA/GTTTTA`	1	--	ds500¹		7		NA NS EA	560
rs5745305^1,2	C	--	10662796(-)	`TGTGAG/ACTTTA`	1	--	ut3¹		2		NS NA	180
rs58765126^1,2	C,	--	10662807(+)	`GATGC-/ATGCCA`	1	--	ut3¹		0	--	--	--	--
rs5745304^1,2	C,F,H,	--	10662986(-)	`CCTTTC/TGGAGC`	1	--	ut3¹ ese³		5		NS EA	522
rs7973^1,2	C,F,A,H,	--	10663098(-)	`CTGTCA/GCCACC`	1	--	ut3¹ ese³		14		NS MN EA NA CSA	2008
rs79983010^1,2	C,	--	10663102(-)	`AGGCC-/CTGTCA`	2	--	ut3¹		0	--	--	--	--
rs5745302^1,2	C,F,H,	--	10663124(-)	`GAAGCC/TGGCAT`	1	--	ut3¹ ese³		7		NS NA	1032
rs5745301^1,2	C,F,H,	--	10663125(-)	`GGAAGC/TCGGCA`	1	--	ut3¹ ese³		13		NS EA NA WA CSA	1488
rs3797110^1,2	C,H,	--	10663177(+)	`TGTGAG/AGCTGT`	1	--	ut3¹		5		NS EA	534
rs200167999^1,2	C	--	10663335(-)	`CACCCA/CCAGCC`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DAP (10679342 - 10761387 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 7 variations for DAP
2 CNVs: 69006 99059
5 Indels: 59221 64119 40734 69007 46745

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DAP

DNA2.0 Custom Variant and Variant Library Synthesis for DAP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DAP for disorders           About GeneDecksing

OMIM gene information: 600954    OMIM disorders: --

4 diseases for DAP:    About MalaCards

hepatitis b hepatitis cerebritis neuronitis

Human Genome Epidemiology (HuGE) Navigator: DAP (30 documents)

Export disorders for DAP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DAP gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with DAP)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. (PubMed id 7828849)^{1, 2, 3, 9} Deiss L.P....Kimchi A. (1995)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins. (PubMed id 16602700)^{1, 2} Zougman A. and Wisniewski J.R. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively. (PubMed id 8530096)^{1, 3} Feinstein E....Huebner K. (1995)
Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions. (PubMed id 9916995)^{1, 9} Levy-Strumpf N. and Kimchi A. (1998)
Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)¹ Kim W....Gygi S.P. (2011)
Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)¹ Anderson C.A....Rioux J.D. (2011)
System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)² Rigbolt K.T....Blagoev B. (2011)
New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)¹ Davila S....Seielstad M. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1611	HGNC: 2672	AceView: DAP	Ensembl:ENSG00000112977	euGenes: HUgn1611
ECgene: DAP	H-InvDB: DAP

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DAP	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for DAP	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/dap/

Intellectual Property for DAP gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DAP gene:
Search GeneIP for patents involving DAP

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
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	EMD Millipore Kits and Assays for the Analysis of DAP
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of DAP
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	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
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	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Browse Recombinant/Natural Proteins

	OriGene Antibodies for DAP		OriGene shRNA RFP for DAP
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAP		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DAP
	OriGene Protein Over-expression Lysate for DAP		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for DAP		OriGene 3'-UTR Clone for DAP
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DAP
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DAP
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAP
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAP
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	GenScript Custom Purified and Recombinant Proteins Services for DAP		GenScript cDNA clones with any tag delivered in your preferred vector for DAP
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	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
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Antibodies & Assays for DAP

	Regulatory tfbs in DAP promoter
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	RT² qPCR Primer Assay in human, mouse, rat DAP
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Search Tocris compounds for DAP

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	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
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Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	DAP antibodies
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	See all of Abcam's Antibodies, Kits and Proteins for DAP
	Custom Antibody / Protein Production Service
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	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

DAP Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for DAP

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAP

	SwitchGear 3'UTR luciferase reporter plasmids for DAP
	SwitchGear Promoter luciferase reporter plasmids for DAP

ThermoFisher Antibodies for DAP

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAP

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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death-associated protein

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DAP Gene

death-associated protein

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