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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAP Gene

protein-coding   GIFtS: 59
GCID: GC05M010679

Death-Associated Protein

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Death-Associated Protein1 2
DAP-12 3
Death-Associated Protein 12
DAP13

External Ids:    HGNC: 26721   Entrez Gene: 16112   Ensembl: ENSG000001129777   OMIM: 6009545   UniProtKB: P513973   

Export aliases for DAP gene to outside databases

Previous GC identifers: GC05M010790 GC05M010732


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DAP Gene:
This gene encodes a basic, proline-rich, 15-kD protein. The protein acts as a positive mediator of programmed cell
death that is induced by interferon-gamma. (provided by RefSeq, Jul 2008)

GeneCards Summary for DAP Gene: 
DAP (death-associated protein) is a protein-coding gene. Diseases associated with DAP include hepatitis b, and cerebritis, and among its related super-pathways are MIF Mediated Glucocorticoid Regulation and Rho Family GTPases. GO annotations related to this gene include death domain binding.

UniProtKB/Swiss-Prot: DAP1_HUMAN, P51397
Function: Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death

Gene Wiki entry for DAP Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_006576.16  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAP gene promoter:
         Nkx3-1   Nkx3-1 v4   p53   Nkx3-1 v1   Tal-1beta   LCR-F1   Nkx3-1 v2   Nkx3-1 v3   Sox9   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DAP promoter sequence
   Search SABiosciences Chromatin IP Primers for DAP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p15.2   Ensembl cytogenetic band:  5p15.2   HGNC cytogenetic band: 5p15.2

DAP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAP gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M010679:  view genomic region     (about GC identifiers)

Start:
10,679,342 bp from pter      End:
10,761,387 bp from pter
Size:
82,046 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DAP1_HUMAN, P51397 (See protein sequence)
Recommended Name: Death-associated protein 1  
Size: 102 amino acids; 11165 Da
Secondary accessions: Q6FGC3 Q9BUC9

Explore the universe of human proteins at neXtProt for DAP: NX_P51397

Explore proteomics data for DAP at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated. Phosphorylation by MTOR inhibits the suppressive activity of DAP toward autophagy
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P51397

  • DAP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DAP Protein Expression
    REFSEQ proteins: NP_004385.1  
    ENSEMBL proteins: 
     ENSP00000230895   ENSP00000394163  

    Human Recombinant Protein Products for DAP: 
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    OriGene MassSpec for DAP 
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    Novus Biologicals DAP Protein
    Novus Biologicals DAP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DAP 


    DAP Antibody Products: 
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    Assay Products for DAP: 
    EMD Millipore Kits and Assays for the Analysis of DAP
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DAP 
    Cloud-Clone Corp. CLIAs for DAP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR024130 DAP1/DAPL1

    Graphical View of Domain Structure for InterPro Entry P51397

    ProtoNet protein and cluster: P51397


    DAP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAP1_HUMAN, P51397
    Function: Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death

         Genatlas biochemistry entry for DAP:
    positive mediator of apoptosis,15kDa,triggered by interferon gamma,death associated protein 1

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0070513death domain binding IPI1087798
         
    DAP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DAP 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DAP

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DAP 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAP 

    miRNA
    Products:
        
    miRTarBase miRNAs that target DAP:
    hsa-mir-183 (MIRT005726)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAP
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate DAP (see all 9):
    hsa-miR-3910 hsa-miR-206 hsa-miR-1 hsa-miR-1184 hsa-miR-124 hsa-miR-550b hsa-miR-506 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidDAP 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DAP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAP

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of DAP

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DAP (see all 7)
    OriGene ORF clones in mouse, rat for DAP
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    Sino Biological Human cDNA Clone for DAP
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                         Customized lentivirus expression plasmids for stable overexpression of DAP 

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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DAP About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1PEDF Induced Signaling
    MIF Mediated Glucocorticoid Regulation0.94
    RAR-Gamma-RXR-Alpha Degradation0.62
    MIF Regulation of Innate Immune Cells0.94
    IL-6 Pathway0.61
    PEDF Induced Signaling0.73
    STAT3 Pathway0.47
    all-trans-Retinoic Acid Signaling in Brain0.71
    Endothelin-1 Signaling Pathway0.46
    2Rho Family GTPases
    Rho Family GTPases0.61
    Molecular Mechanisms of Cancer0.51
    ERK Signaling0.61
    3Akt Signaling
    Akt Signaling0.60
    p38 Signaling0.60
    4PAK Pathway
    PAK Pathway0.56
    Antioxidant Action of Vitamin-C0.56
    5TNF-alpha/NF-kB Signaling Pathway
    TNF-alpha/NF-kB Signaling Pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for DAP (see all 15)
        MIF Regulation of Innate Immune Cells
    STAT3 Pathway
    Endothelin-1 Signaling Pathway
    Molecular Mechanisms of Cancer
    Antioxidant Action of Vitamin-C

    1 Cell Signaling Technology (CST) Pathway for DAP
        Apoptosis and Autophagy

    1 BioSystems Pathway for DAP
        TNF-alpha/NF-kB Signaling Pathway




    DAP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 10)

    5/13 Interacting proteins for DAP (P513973 ENSP000002308954) via UniProtKB, MINT, STRING, and/or I2D (see all 13)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SETDB1Q150473I2D: score=4 
    MTORP423453I2D: score=1 
    TNFRSF1AP194383I2D: score=1 
    KRT33AENSP000000077354STRING: ENSP00000007735
    KIF4AENSP000003635244STRING: ENSP00000363524
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006914autophagy IEA--
    GO:0006915apoptotic process IGI7828849
    GO:0006919activation of cysteine-type endopeptidase activity involved in apoptotic process IMP1087798
    GO:0010507negative regulation of autophagy IMP--
    GO:0032088negative regulation of NF-kappaB transcription factor activity IMP1087798

    DAP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DAP (DAP1)

    Search CenterWatch for drugs/clinical trials and news about DAP / DAP1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DAP gene: 
    NM_004394.2  

    Unigene Cluster for DAP:

    Death-associated protein
    Hs.75189  [show with all ESTs]
    Unigene Representative Sequence: NM_004394
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000230895(uc003jez.4 uc011cmw.2) ENST00000432074 ENST00000514882
    ENST00000508253 ENST00000510546 ENST00000508646
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAP
    8/9 QIAGEN miScript miRNA Assays for microRNAs that regulate DAP (see all 9):
    hsa-miR-3910 hsa-miR-206 hsa-miR-1 hsa-miR-1184 hsa-miR-124 hsa-miR-550b hsa-miR-506 hsa-miR-613
    SwitchGear 3'UTR luciferase reporter plasmidDAP 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DAP
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAP
    Clone
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    OriGene clones in human, mouse for DAP (see all 7)
    OriGene ORF clones in mouse, rat for DAP
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DAP (NM_004394)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAP
    Sirion Biotech Customized lentivirus for stable overexpression of DAP 
                         Customized lentivirus expression plasmids for stable overexpression of DAP 
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DAP
    OriGene qSTAR qPCR primer pairs in human, mouse for DAP
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DAP
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAP

    Additional mRNA sequence: 

    AF056450.1 AK298670.1 AK311783.1 BC002726.2 BT006925.1 CR542184.1 X76105.1 

    18 DOTS entries:

    DT.100848796  DT.97786156  DT.75121046  DT.99982408  DT.100848786  DT.100848795  DT.100848787  DT.92449320 
    DT.100848785  DT.95372900  DT.100640726  DT.100848789  DT.92449311  DT.92449318  DT.95372894  DT.99942273 
    DT.100800411  DT.100848780 

    24/692 AceView cDNA sequences (see all 692):

    AI624309 CA943598 AI222783 AI222790 AL120966 CB161665 CA429360 CK903644 
    CR607455 CK725161 BG121970 BG403091 AA846770 AA974183 BM761744 AW182742 
    AA774142 CR542184 CA422913 AI079137 AA569000 AI951448 BM910386 BQ669882 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAP expression in normal human tissues (normalized intensities)      DAP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CATCTGTGAG
    DAP Expression
    About this image


    DAP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/6 selected tissues (see all 6) fully expand
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Thoracic Rib
             skeleton/cranium/viscerocranium   
     
     Cartilage (Muscoskeletal System)    fully expand to see all 2 entries
             Intervertebral Disc Nucleus Pulposus Cells Lumbar Intervertebral Disc
             skeleton/cranium/viscerocranium   
     
     Neural Crest (Gastrulation Derivatives)
             skeleton/cranium/viscerocranium   
     
     Pancreas (Endocrine System)
             visceral organ/gut/foregut-midgut junction   
     
     Primitive Streak (Early Embryonic Tissues)
             Notochord

    See DAP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAP

    SOURCE GeneReport for Unigene cluster: Hs.75189
        SABiosciences Expression via Pathway-Focused PCR Array including DAP: 
              Apoptosis 384HT in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DAP gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dap1 , 5 death-associated protein1, 5 86.6(n)1
    96.08(a)1
      15 (12.67 cM)5
    2234531  NM_146057.31  NP_666169.11 
     312243855 
    chicken
    (Gallus gallus)
    Aves DAP1 death-associated protein 79.74(n)
    83.33(a)
      420923  NM_001031003.1  NP_001026174.1 
    lizard
    (Anolis carolinensis)
    Reptilia DAP6
    Uncharacterized protein
    78(a)
    1 ↔ 1
    4(66392943-66465473)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.135812 Xenopus laevis, Similar to death-associated protein, more 77.47(n)    BC044126.1 
    zebrafish
    (Danio rerio)
    Actinopterygii BC049052.12   -- 74.67(n)   58093  BC049052.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG123846
    --
    45(a)
    1 ↔ 1
    2R(7245407-7246674)


    ENSEMBL Gene Tree for DAP (if available)
    TreeFam Gene Tree for DAP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DAP gene
    1 SIMAP similar gene for DAP using alignment to 3 protein entries:     DAP1_HUMAN (see all proteins):
    DAPL1

    DAP for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1909 SNPs in DAP are shown (see all 1909)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1894208251,2
    --10637226(+) TGGATG/TGCCAG 1 -- ds50010--------
    rs168851261,2
    C,F,H--10637449(+) CTGACA/GTTTTA 1 -- ds50017Minor allele frequency- G:0.00NA NS EA 560
    rs1810706591,2
    C--10637559(+) CTACTA/GAAACC 1 -- ds50010--------
    rs1170299711,2
    C,F--10637725(+) CTAAAG/CCTCAC 1 -- ut311Minor allele frequency- C:0.03EA 120
    rs57453051,2
    C--10637726(-) TGTGAG/ACTTTA 1 -- ut312Minor allele frequency- A:0.01NS NA 180
    rs587651261,2
    C--10637737(+) GATGC-/ATGCCA 1 -- ut310--------
    rs1844944681,2
    --10637761(+) GTACAC/TAAAAA 1 -- ut310--------
    rs1902425511,2
    --10637802(+) TGGCTA/GAAGAC 1 -- ut310--------
    rs57453041,2
    C,F,H--10637916(-) CCTTTC/TGGAGC 1 -- ut31 ese35Minor allele frequency- T:0.02NS EA 522
    rs79731,2
    C,F,A,H--10638028(-) CTGTCA/GCCACC 1 -- ut31 ese314Minor allele frequency- G:0.13NS MN EA NA CSA 2008

    HapMap Linkage Disequilibrium report for DAP (10679342 - 10761387 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/12 variations for DAP (see all 12):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2664774CNV Deletion23128226
    esv2464339CNV Deletion19546169
    esv2312126CNV Deletion18987734
    esv2729747CNV Deletion23290073
    esv2729746CNV Deletion23290073
    nsv819968CNV Loss19587683
    nsv521304CNV Loss19592680
    esv24449CNV Loss19812545
    esv22939CNV Loss19812545
    esv23832CNV Gain19812545

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DAP
    DNA2.0 Custom Variant and Variant Library Synthesis for DAP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 600954    OMIM disorders: --

    4 diseases for DAP:    About MalaCards
    hepatitis b    cerebritis    hepatitis    neuronitis


    DAP for disorders           About GeneDecksing

    Genetic Association Database (GAD): DAP
    Human Genome Epidemiology (HuGE) Navigator: DAP (30 documents)

    Export disorders for DAP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAP gene, integrated from 9 sources (see all 28):
    (articles sorted by number of sources associating them with DAP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. (PubMed id 7828849)1, 2, 3, 9 Deiss L.P....Kimchi A. (1995)
    2. Meta-analysis identifies 29 additional ulcerative col itis risk loci, increasing the number of confirmed associations to 47. (PubMed id 21297633)1, 4 Anderson C.A....Rioux J.D. (2011)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    5. Beyond linker histones and high mobility group proteins: global profiling of perchloric acid soluble proteins. (PubMed id 16602700)1, 2 Zougman A. and Wisniewski J.R. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Assignment of DAP1 and DAPK--genes that positively mediate programmed cell death triggered by IFN-gamma--to chromosome regions 5p12.2 and 9q34.1, respectively. (PubMed id 8530096)1, 3 Feinstein E....Huebner K. (1995)
    8. Death associated proteins (DAPs): from gene identification to the analysis of their apoptotic and tumor suppressive functions. (PubMed id 9916995)1, 9 Levy-Strumpf N. and Kimchi A. (1998)
    9. Host-microbe interactions have shaped the genetic arch itecture of inflammatory bowel disease. (PubMed id 23128233)1 Jostins L....Cho J.H. (2012)
    10. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1611 HGNC: 2672 AceView: DAP Ensembl:ENSG00000112977 euGenes: HUgn1611
    ECgene: DAP H-InvDB: DAP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DAP Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/dap/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DAP gene:
    Search GeneIP for patents involving DAP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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