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Aliases for DAOA Gene

Aliases for DAOA Gene

  • D-Amino Acid Oxidase Activator 2 3 5
  • G72 Transcript 2 3
  • Schizophrenia- And Bipolar Disorder-Associated Protein G72 3
  • Protein G72 4
  • LG72 3
  • SG72 3
  • G72 4

External Ids for DAOA Gene

Previous GeneCards Identifiers for DAOA Gene

  • GC13P103816
  • GC13P104916
  • GC13P106118
  • GC13P086708

Summaries for DAOA Gene

Entrez Gene Summary for DAOA Gene

  • This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011]

GeneCards Summary for DAOA Gene

DAOA (D-Amino Acid Oxidase Activator) is a Protein Coding gene. Diseases associated with DAOA include schizophrenia and childhood-onset schizophrenia. GO annotations related to this gene include enzyme binding and enzyme activator activity.

UniProtKB/Swiss-Prot for DAOA Gene

  • Seems to activate D-amino acid oxidase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAOA Gene

Genomics for DAOA Gene

Regulatory Elements for DAOA Gene

Genomic Location for DAOA Gene

Chromosome:
13
Start:
105,465,867 bp from pter
End:
105,491,034 bp from pter
Size:
25,168 bases
Orientation:
Plus strand

Genomic View for DAOA Gene

Genes around DAOA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAOA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAOA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAOA Gene

Proteins for DAOA Gene

  • Protein details for DAOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59103-DAOA_HUMAN
    Recommended name:
    D-amino acid oxidase activator
    Protein Accession:
    P59103
    Secondary Accessions:
    • A6NKG7
    • Q0VAE6
    • Q5VX59
    • Q86Y17
    • Q8IWM4

    Protein attributes for DAOA Gene

    Size:
    153 amino acids
    Molecular mass:
    18108 Da
    Quaternary structure:
    • Associates with D-amino acid oxidase (DAAO).

    Alternative splice isoforms for DAOA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAOA Gene

Proteomics data for DAOA Gene at MOPED

Post-translational modifications for DAOA Gene

No Post-translational modifications

Antibody Products

No data available for DME Specific Peptides for DAOA Gene

Domains & Families for DAOA Gene

Protein Domains for DAOA Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DAOA: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DAOA Gene

Function for DAOA Gene

Molecular function for DAOA Gene

UniProtKB/Swiss-Prot Function:
Seems to activate D-amino acid oxidase.

Phenotypes for DAOA Gene

genes like me logo Genes that share phenotypes with DAOA: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for DAOA Gene

Localization for DAOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAOA Gene

Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAOA Gene COMPARTMENTS Subcellular localization image for DAOA gene
Compartment Confidence
golgi apparatus 5
mitochondrion 5
nucleus 3
peroxisome 2

Gene Ontology (GO) - Cellular Components for DAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 21679769
GO:0048471 perinuclear region of cytoplasm IDA 21679769
genes like me logo Genes that share ontologies with DAOA: view

Pathways & Interactions for DAOA Gene

SuperPathways for DAOA Gene

No Data Available

Interacting Proteins for DAOA Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000365103%0d%0a9606.ENSP00000228476%0d%0a
Selected Interacting proteins: P59103-DAOA_HUMAN ENSP00000365103 for DAOA Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for DAOA Gene

None

No data available for Pathways by source and SIGNOR curated interactions for DAOA Gene

Drugs & Compounds for DAOA Gene

(5) Drugs for DAOA Gene - From: Novoseek and PharmGKB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Methamphetamine Approved, Illicit Pharma 169

(1) Additional Compounds for DAOA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with DAOA: view

Transcripts for DAOA Gene

mRNA/cDNA for DAOA Gene

(4) REFSEQ mRNAs :
(7) Selected AceView cDNA sequences:
(11) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for DAOA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: - -
SP3:
SP4: - - -

Relevant External Links for DAOA Gene

GeneLoc Exon Structure for
DAOA
ECgene alternative splicing isoforms for
DAOA

Expression for DAOA Gene

mRNA expression in normal human tissues for DAOA Gene

SOURCE GeneReport for Unigene cluster for DAOA Gene Hs.381382

mRNA Expression by UniProt/SwissProt for DAOA Gene

P59103-DAOA_HUMAN
Tissue specificity: Expressed in amygdala, caudate nucleus, spinal cord and testis.
genes like me logo Genes that share expression patterns with DAOA: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for DAOA Gene

Orthologs for DAOA Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DAOA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAOA 35
  • 92.86 (n)
  • 88.78 (a)
DAOA 36
  • 98 (a)
OneToOne
Species with no ortholog for DAOA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DAOA Gene

ENSEMBL:
Gene Tree for DAOA (if available)
TreeFam:
Gene Tree for DAOA (if available)

Paralogs for DAOA Gene

(1) SIMAP similar genes for DAOA Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DAOA: view

No data available for Paralogs for DAOA Gene

Variants for DAOA Gene

Sequence variations from dbSNP and Humsavar for DAOA Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type
VAR_014313 -
VAR_050943 -

Structural Variations from Database of Genomic Variants (DGV) for DAOA Gene

Variant ID Type Subtype PubMed ID
nsv519018 CNV Loss 19592680
esv275034 CNV Gain+Loss 21479260

Variation tolerance for DAOA Gene

Residual Variation Intolerance Score: 52% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.43; 77.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAOA Gene

HapMap Linkage Disequilibrium report
DAOA
Human Gene Mutation Database (HGMD)
DAOA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAOA Gene

Disorders for DAOA Gene

MalaCards: The human disease database

(5) MalaCards diseases for DAOA Gene - From: OMIM, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
schizophrenia
  • schizophrenia 12
childhood-onset schizophrenia
  • childhood schizophrenia
bipolar disorder
  • bipolar depression
psychotic disorder
  • mental or behavioural disorder
mood disorder
  • episodic mood disorder
- elite association - COSMIC cancer census association via MalaCards
Search DAOA in MalaCards View complete list of genes associated with diseases

Relevant External Links for DAOA

Genetic Association Database (GAD)
DAOA
Human Genome Epidemiology (HuGE) Navigator
DAOA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAOA
genes like me logo Genes that share disorders with DAOA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAOA Gene

Publications for DAOA Gene

  1. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. (PMID: 12364586) Chumakov I. … Cohen D. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 23 67
  2. Genetic variation in the G720/G30 gene locus (DAOA) influences the occurrence of psychotic symptoms in patients with Alzheimer's disease. (PMID: 20009237) Di Maria E. … Gennarelli M. (J. Alzheimers Dis. 2009) 3 23
  3. G72/G30 (DAOA) and juvenile-onset mood disorders. (PMID: 19089835) Gomez L. … Barr C.L. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23
  4. Common and rare variants of DAOA in bipolar disorder. (PMID: 19194963) Maheshwari M. … Gibbs R.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009) 3 23
  5. Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study. (PMID: 19237267) Ohi K. … Takeda M. (Schizophr. Res. 2009) 3 23

Products for DAOA Gene

Sources for DAOA Gene

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