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Aliases for DAOA Gene

Aliases for DAOA Gene

  • D-Amino Acid Oxidase Activator 2 3
  • G72 Transcript 2 3
  • G72 4 6
  • Schizophrenia- And Bipolar Disorder-Associated Protein G72 3
  • Protein G72 4
  • LG72 3
  • SG72 3

External Ids for DAOA Gene

Previous GeneCards Identifiers for DAOA Gene

  • GC13P103816
  • GC13P104916
  • GC13P106118
  • GC13P086708

Summaries for DAOA Gene

Entrez Gene Summary for DAOA Gene

  • This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Mar 2011]

GeneCards Summary for DAOA Gene

DAOA (D-Amino Acid Oxidase Activator) is a Protein Coding gene. Diseases associated with DAOA include childhood-onset schizophrenia and bipolar disorder. GO annotations related to this gene include enzyme binding and enzyme activator activity.

UniProtKB/Swiss-Prot for DAOA Gene

  • Seems to activate D-amino acid oxidase

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAOA Gene

Genomics for DAOA Gene

Regulatory Elements for DAOA Gene

Genomic Location for DAOA Gene

Start:
105,465,867 bp from pter
End:
105,491,034 bp from pter
Size:
25,168 bases
Orientation:
Plus strand

Genomic View for DAOA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAOA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAOA Gene

Proteins for DAOA Gene

  • Protein details for DAOA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P59103-DAOA_HUMAN
    Recommended name:
    D-amino acid oxidase activator
    Protein Accession:
    P59103
    Secondary Accessions:
    • A6NKG7
    • Q0VAE6
    • Q5VX59
    • Q86Y17
    • Q8IWM4

    Protein attributes for DAOA Gene

    Size:
    153 amino acids
    Molecular mass:
    18108 Da
    Quaternary structure:
    • Associates with D-amino acid oxidase (DAAO)

    Alternative splice isoforms for DAOA Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAOA Gene

Proteomics data for DAOA Gene at MOPED

Post-translational modifications for DAOA Gene

No Post-translational modifications

No data available for DME Specific Peptides for DAOA Gene

Domains for DAOA Gene

Protein Domains for DAOA Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DAOA Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DAOA: view

No data available for Gene Families and UniProtKB/Swiss-Prot for DAOA Gene

Function for DAOA Gene

Molecular function for DAOA Gene

UniProtKB/Swiss-Prot Function: Seems to activate D-amino acid oxidase

Gene Ontology (GO) - Molecular Function for DAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008047 enzyme activator activity IDA 12364586
GO:0019899 enzyme binding IPI 12364586
genes like me logo Genes that share ontologies with DAOA: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DAOA Gene

Localization for DAOA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAOA Gene

Golgi apparatus.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAOA Gene COMPARTMENTS Subcellular localization image for DAOA gene
Compartment Confidence
golgi apparatus 5
mitochondrion 5
nucleus 3
peroxisome 1

Gene Ontology (GO) - Cellular Components for DAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA 21679769
GO:0005794 Golgi apparatus IDA 12364586
GO:0048471 perinuclear region of cytoplasm IDA 21679769
genes like me logo Genes that share ontologies with DAOA: view

Pathways for DAOA Gene

SuperPathways for DAOA Gene

No Data Available

Interacting Proteins for DAOA Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000365103%0d%0a9606.ENSP00000228476%0d%0a
Selected Interacting proteins: P59103-DAOA_HUMAN ENSP00000365103 for DAOA Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for DAOA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043085 positive regulation of catalytic activity IDA 12364586
GO:1900758 negative regulation of D-amino-acid oxidase activity IDA 21679769
genes like me logo Genes that share ontologies with DAOA: view

No data available for Pathways by source for DAOA Gene

Compounds for DAOA Gene

(5) Novoseek inferred chemical compound relationships for DAOA Gene

Compound -log(P) Hits PubMed IDs
nmda 61.8 14
glutamate 45.1 7
serine 43.5 9
dopamine 34.7 1
proline 15.5 1
genes like me logo Genes that share compounds with DAOA: view

Transcripts for DAOA Gene

mRNA/cDNA for DAOA Gene

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAOA

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAOA Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1: - - -
SP2: - -
SP3:
SP4: - - -

Relevant External Links for DAOA Gene

GeneLoc Exon Structure for
DAOA
ECgene alternative splicing isoforms for
DAOA

Expression for DAOA Gene

mRNA expression in normal human tissues for DAOA Gene

SOURCE GeneReport for Unigene cluster for DAOA Gene Hs.381382

mRNA Expression by UniProt/SwissProt for DAOA Gene

P59103-DAOA_HUMAN
Tissue specificity: Expressed in amygdala, caudate nucleus, spinal cord and testis
genes like me logo Genes that share expressions with DAOA: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for DAOA Gene

Orthologs for DAOA Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for DAOA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAOA 35
  • 92.86 (n)
  • 88.78 (a)
DAOA 36
  • 98 (a)
OneToOne
Species with no ortholog for DAOA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for DAOA Gene

ENSEMBL:
Gene Tree for DAOA (if available)
TreeFam:
Gene Tree for DAOA (if available)

Paralogs for DAOA Gene

Selected SIMAP similar genes for DAOA Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DAOA: view

No data available for Paralogs for DAOA Gene

Variants for DAOA Gene

Sequence variations from dbSNP and Humsavar for DAOA Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
VAR_014313 -
VAR_050943 -

Structural Variations from Database of Genomic Variants (DGV) for DAOA Gene

Variant ID Type Subtype PubMed ID
nsv519018 CNV Loss 19592680
esv275034 CNV Gain+Loss 21479260

Relevant External Links for DAOA Gene

HapMap Linkage Disequilibrium report
DAOA
Human Gene Mutation Database (HGMD)
DAOA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAOA Gene

Disorders for DAOA Gene

MalaCards: The human disease database

MalaCards: The human disease database. (3) Diseases for DAOA Gene including...

Search for DAOA Gene in MalaCards »

(1) OMIM Diseases for DAOA Gene (607408)

(2) University of Copenhagen DISEASES for DAOA Gene

(6) Novoseek inferred disease relationships for DAOA Gene

Disease -log(P) Hits PubMed IDs
schizophrenia 78.4 69
bipolar disorder 76.3 18
hypofunction 67.1 1
psychotic 49.5 3
mood disorders 42.1 2

Relevant External Links for DAOA

Genetic Association Database (GAD)
DAOA
Human Genome Epidemiology (HuGE) Navigator
DAOA
genes like me logo Genes that share disorders with DAOA: view

No data available for UniProtKB/Swiss-Prot for DAOA Gene

Publications for DAOA Gene

  1. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. (PMID: 12364586) Chumakov I. … Cohen D. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 4 23
  2. Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified. (PMID: 15121480) Addington A.M. … Rapoport J.L. (Biol. Psychiatry 2004) 3 23 48
  3. Association of G72/G30 with schizophrenia in the Chinese population. (PMID: 15194506) Wang X. … He L. (Biochem. Biophys. Res. Commun. 2004) 3 23 48
  4. Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations. (PMID: 16402132) Ma J. … He L. (Mol. Psychiatry 2006) 3 23 48
  5. The G72/G30 gene complex and cognitive abnormalities in schizophrenia. (PMID: 16554747) Goldberg T.E. … Weinberger D.R. (Neuropsychopharmacology 2006) 3 23 48

Products for DAOA Gene

Sources for DAOA Gene

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