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DAOA Gene

protein-coding GIFtS: 43

GC13P104916

D-amino acid oxidase activator
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
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Aliases
G72 ^¹, ², ³, ⁵
LG72 ^²
OTTHUMP00000038758 ^²
SG72 ^²

Descriptions
D-amino acid oxidase activator ^²
Protein G72 ^³
schizophrenia- and bipolar disorder-associated protein G72 ^²

External Ids
HGNC: 21191¹
Entrez Gene: 267012²
UniProtKB: P59103³
Ensembl: ENSG00000182346⁷

Search outside databases for aliases for DAOA gene

Previous GC identifer: GC13P103816

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for DAOA:

This gene encodes a protein that is an activator of the FAD-dependent enzyme D-amino acid oxidase,

which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA)

type glutamate receptors. Polymorphisms in this gene have been implicated in susceptibility to

schizophrenia and bipolar affective disorder, possibly due to decreased levels of D-serine and

decreased NMDA receptor functioning. Alternatively spliced transcript variants of this gene have

been described, but their biological validity has not been determined. [provided by RefSeq]

UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103

Function: Seems to activate D-amino acid oxidase

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DAOA gene

Entrez Gene cytogenetic band: 13q33.2|13q34 Ensembl cytogenetic band: 13q33.2 HGNC cytogenetic band: 13q33.2

DAOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13P104916: (about GC identifiers)

Start:	104,916,365 bp from pter
End:	104,941,384 bp from pter
Size:	25,020 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000013.9 NT_009952.14

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103 (See protein sequence)

Recommended Name: D-amino acid oxidase activator

Size: 153 amino acids; 18108 Da

Subunit: Associates with D-amino acid oxidase (DAAO)

Subcellular location: Golgi apparatus

Secondary accessions: Q0VAE6 Q5VX59

Alternative splicing: 2 isoforms: P59103-1 P59103-2

REFSEQ proteins: NP_758958.3

ENSEMBL proteins:

ENSP00000365103 ENSP00000329951

Human Recombinant Proteins

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Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

1 Gene Ontology (GO) cellular component term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005794	Golgi apparatus	IEA	--

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Antibodies for DAOA:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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	Search for antibodies at Abcam and the World's Antibody Gateway (free search engine of over 150 antibody companies)
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for DAOA

Assays for DAOA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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ProtoNet protein and cluster: P59103

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAOA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_172370

Applied Biosystems Silencer® siRNAs for DAOA

Sigma-Aldrich siRNA for DAOA

Sigma-Aldrich shRNA for DAOA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_172370
Myc/DDK tagged cDNA clone in CMV expression vector: NM_172370
untagged cDNA clone in CMV expression vector: NM_172370

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_172370

UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103

Function: Seems to activate D-amino acid oxidase

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Gene Network Central^TM Interacting Genes and Proteins Network for DAOA

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DAOA
1 Novoseek chemical compound relationship for DAOA gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
proline	19.98	1	17197372 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAOA)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_172370

Sigma-Aldrich siRNA for DAOA

Sigma-Aldrich shRNA for DAOA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_172370

REFSEQ mRNAs for DAOA gene:

NM_172370.3

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_172370

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_172370
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_172370
                                 untagged cDNA clone in CMV expression vector: NM_172370

Additional cDNA sequence:

AY138546.1 AY138547.1 AY170469.2 AY170470.2 AY170471.1 AY223901.1 BC121090.1 BC121091.1

DQ343761.1 DQ357223.1 DQ386869.1 DQ386870.1

4 DOTS entries:

DT.100013795 DT.100013798 DT.100748476 DT.100748477

7 AceView cDNA sequences:

AY170469 AY170470 AY223901 AY138547 AY170471 NM_172370 AY138546

highest scoring ESTs for DAOA:

AY138546 AY138547 AY170469 AY170471 AY170470 AY223901 NM_172370 BC121090 BC121091 DQ343761

Unigene Cluster for DAOA:

D-amino acid oxidase activator

Hs.381382

Unigene Representative Sequence: DQ357223

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for DAOA

ExUns:	1a	·	1b	^	2a	·	2b	^	3a	·	3b	^	4	^	5	^	6a	·	6b	^	7a	·	7b
SP1:					-										-		-
SP2:															-		-
SP3:
SP4:													-		-		-

About this scheme

ECgene alternative splicing isoforms for DAOA

2 Ensembl transcripts including schematic representations:

ENST00000375936 ENST00000329625

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DAOA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DAOA

¹ / ²

2 probe-sets matching DAOA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1555662_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
1555640_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GCAAGAAACT

SOURCE GeneReport for Unigene cluster: Hs.381382
UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103
Tissue specificity: Expressed in amygdala, caudate nucleus, spinal cord and testis

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
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ENSEMBL Gene Tree for DAOA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/242 NCBI SNPs in DAOA are shown (see all 242 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 129)

AB	SNP ID	Valid	Chr 13 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1341403^1,2	A,C,F,H,O	104914808(+)	`GTCTGC/AAATAG`	1	--	ng5¹ tfbs³		7		EU EA WA NA	556
	rs3916967^1,2	A,C,F,H	104915349(-)	`CAATTA/GTGATA`	1	--	ng5¹		8		NA EU EA WA	1036
	rs2391191^1,2	C,F,H,O	104917447(+)	`TCAAAA/GGAGCA`	1	R/K	mis¹ ese³		18		NS EU EA WA NA	1634
	rs12864685^1,2	C,F,H	104941856(+)	`CTCAGC/TTTTGT`	1	--	ng3¹		11		NA EU EA WA	960
	rs9558562^1,2	C,F,H	104922938(+)	`GATGGA/GAGAGA`	1	K/E	mis¹ trp³		4		EU EA WA	406
	rs16966678^1,2	F,H	104914463(+)	`TGGACA/GTGGGT`	1	--	ng5¹ tfbs³		7		NA EU EA WA	560
	rs9586857^1,2	F,H	104916208(+)	`TATCCA/GCAAAA`	1	--	ng5¹		4		EU EA WA	420
--	rs45476401^1,2	F	104916613(+)	`AATGCC/TGATGA`	1	--	ut5¹		1		EA	592
	rs1361562^1,2	C	104915993(+)	`ATACAA/GATATA`	1	--	ng5¹ tfbs³		0	--	--	--	--
	rs2893229^1,2	A,C,F,H,O	104929201(+)	`GGCAAA/GTAGCA`	1	--	int¹		11		EU EA WA NA	976

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HapMap Linkage Disequilibrium images for DAOA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 607408 disorders: 181500

UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103

May be implicated in schizophrenia

6 Novoseek disease relationships for DAOA gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia	78.38	78	16842973 (6), 19237267 (4), 14966479 (4), 19077230 (4) (see all 27)
bipolar disorder	75.72	9	14966479 (2), 18466879 (1), 16263850 (1), 17684499 (1) (see all 6)
hypofunction	70.13	1	12625025 (1)
psychotic	49.40	4	18466879 (1), 17890006 (1)
mood disorders	40.23	1	16365481 (1)
psychiatric disorder	22.94	1	14966479 (1)

About this table

Human Gene Mutation Database: DAOA
Genetic Association Database: DAOA
Human Genome Epidemiology Navigator: DAOA (40 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/76 PubMed articles for DAOA gene (see all 76 ):

Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. (PubMed id 12364586)^{1, 2, 3, 4} Chumakov I.... Cohen D. (2002)
Association of G72/G30 with schizophrenia in the Chinese population. (PubMed id 15194506)^{1, 3, 6} Wang X....He L. (2004)
Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes. (PubMed id 16263850)^{1, 3, 6} Schulze T.G....Rietschel M. (2005)
Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified. (PubMed id 15121480)^{1, 3, 6} Addington A.M....Rapoport J.L. (2004)
Transmission disequilibrium and haplotype analyses of the G72/G30 locus: suggestive linkage to schizophrenia in Palestinian Arabs living in the North of Israel. (PubMed id 16082701)^{3, 6} Korostishevsky M....Navon R. (2006)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{3, 4} Hillman R.T.... Brenner S.E. (2004)
Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis. (PubMed id 15271585)^{3, 6} Korostishevsky M....Navon R. (2004)
The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{3, 4} Dunham A.... Ross M.T. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Investigation of G72 (DAOA) expression in the human brain. (PubMed id 19077230)^{1, 3} Benzel I....Maycox P.R. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 267012	HGNC: 21191	AceView: DAOA	Ensembl:ENSG00000182346	euGenes: HUgn267012
ECgene: DAOA	H-InvDB: DAOA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Licensable Technologies for DAOA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for DAOA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DAOA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DAOA		Browse antibodies at Sigma-Aldrich
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DAOA Gene

protein-coding GIFtS: 43

Aliases &
Descriptions
for DAOA

Summaries
for DAOA

Genomic Location
for DAOA

Proteins
for DAOA

Protein Domains/
Families
for DAOA

Gene Function
for DAOA

Pathways & Interactions
for DAOA

Drugs & Compounds
for DAOA

Transcripts
for DAOA

Expression
for DAOA

Orthologs
for DAOA

Paralogs
for DAOA

SNPs/Variants
for DAOA

Disorders & Mutations
for DAOA

Medical News
for DAOA

Publications
for DAOA

Search for DAOA

Genome Databases showing DAOA

Other Databases showing DAOA

Specialized Databases showing DAOA

Licensable Technologies
for DAOA

Services
for DAOA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DAOA Gene

protein-coding GIFtS: 43

Aliases & Descriptionsfor DAOA

Summariesfor DAOA

Genomic Locationfor DAOA

Proteinsfor DAOA

Protein Domains/Familiesfor DAOA

Gene Functionfor DAOA

Pathways & Interactionsfor DAOA

Drugs & Compoundsfor DAOA

Transcriptsfor DAOA

Expression for DAOA

Orthologsfor DAOA

Paralogsfor DAOA

SNPs/Variantsfor DAOA

Disorders & Mutationsfor DAOA

Medical Newsfor DAOA

Publicationsfor DAOA

Search for DAOA

Genome Databases showing DAOA

Other Databases showing DAOA

Specialized Databases showing DAOA

Licensable Technologiesfor DAOA

Servicesfor DAOA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DAOA

Summaries
for DAOA

Genomic Location
for DAOA

Proteins
for DAOA

Protein Domains/
Families
for DAOA

Gene Function
for DAOA

Pathways & Interactions
for DAOA

Drugs & Compounds
for DAOA

Transcripts
for DAOA

Expression
for DAOA

Orthologs
for DAOA

Paralogs
for DAOA

SNPs/Variants
for DAOA

Disorders & Mutations
for DAOA

Medical News
for DAOA

Publications
for DAOA

Licensable Technologies
for DAOA

Services
for DAOA