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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAOA Gene

protein-coding   GIFtS: 47
GCID: GC13P106118

D-amino acid oxidase activator

 Explore 8 diseases affiliated with
DAOA via our new
 Human Malady Compendium 
Biological research products
for DAOA
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
D-Amino Acid Oxidase Activator1 2     G72 Transcript2
G721 2 3 5     Schizophrenia- And Bipolar Disorder-Associated Protein G722
LG722     Protein G723
SG722     

External Ids:    HGNC: 211911   Entrez Gene: 2670122   Ensembl: ENSG000001823467   OMIM: 6074085   UniProtKB: P591033   

Export aliases for DAOA gene to outside databases

Previous GC identifers: GC13P103816 GC13P104916 GC13P086708


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DAOA:
This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the
gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also
suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms
in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively
spliced transcript variants encoding different isoforms have been identified.(provided by RefSeq, Mar 2011)

UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103
Function: Seems to activate D-amino acid oxidase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.1  NT_009952.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAOA gene promoter:
         GATA-3   Pbx1a   MyoD   CUTL1   GATA-2   GATA-1   Meis-1b   S8   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAOA promoter sequence
   Search SABiosciences Chromatin IP Primers for DAOA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAOA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q33.2|13q34   Ensembl cytogenetic band:  13q33.2   HGNC cytogenetic band: 13q33.2

DAOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAOA gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P106118:  view genomic region     (about GC identifiers)

Start:
106,118,216 bp from pter      End:
106,143,383 bp from pter
Size:
25,168 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103 (See protein sequence)
Recommended Name: D-amino acid oxidase activator  
Size: 153 amino acids; 18108 Da
Subunit: Associates with D-amino acid oxidase (DAAO)
Subcellular location: Golgi apparatus
Secondary accessions: A6NKG7 Q0VAE6 Q5VX59 Q86Y17 Q8IWM4
Alternative splicing: 4 isoforms:  P59103-1   P59103-2   P59103-3   P59103-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DAOA: NX_P59103

DAOA Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins (3 alternative transcripts): 
NP_001155284.1  NP_001155286.1  NP_758958.3  

ENSEMBL proteins: 
 ENSP00000365103   ENSP00000329951   ENSP00000453831  

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Uscn Proteins for DAOA

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA--
GO:0005794Golgi apparatus IDA12364586
GO:0048471perinuclear region of cytoplasm IDA--


DAOA for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: P59103


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

     UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103
Function: Seems to activate D-amino acid oxidase

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Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008047enzyme activator activity IDA12364586
GO:0019899enzyme binding IPI--


DAOA for ontologies           About GeneDecksing



(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAOA

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for DAOA (P591032, 3 ENSP000003651034) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
DAOP149203, ENSP000002284764I2D: score=1 STRING: ENSP00000228476
--O350782MINT-8204583
About this table

Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0043085positive regulation of catalytic activity IDA12364586
GO:1900758negative regulation of D-amino-acid oxidase activity IDA--


DAOA for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DAOA for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DAOA
5 Novoseek chemical compound relationships for DAOA gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nmda 61.8 25 16554747 (2), 17152404 (1), 17492767 (1), 16842973 (1) (see all 13)
glutamate 45.1 10 17250995 (2), 19482054 (1), 17890006 (1), 19439994 (1) (see all 6)
serine 43.5 12 17250995 (2), 19482054 (1), 19591808 (1), 18628682 (1) (see all 8)
dopamine 34.7 1 18988532 (1)
proline 15.5 1 17197372 (1)

Search CenterWatch for drugs/clinical trials and news about DAOA 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DAOA gene (3 alternative transcripts): 
NM_001161812.1  NM_001161814.1  NM_172370.3  

Unigene Cluster for DAOA:

D-amino acid oxidase activator
Hs.381382
Unigene Representative Sequence: DQ357223
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000489237 ENST00000473269(uc001vqb.3) ENST00000488534 ENST00000375936
ENST00000329625 ENST00000471432(uc001vqe.3) ENST00000559369(uc010tjf.2 uc001vpz.3 uc010agd.3 uc010tjg.2 uc001vqc.3)


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hsa-miR-374a* hsa-miR-34c-3p hsa-miR-2115
SwitchGear 3'UTR luciferase reporter plasmidDAOA 3' UTR sequence
Inhib. RNA
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Clone
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Additional cDNA sequence: 

AY138546.1 AY138547.1 AY170469.2 AY170470.2 AY170471.1 AY223901.1 BC121090.1 BC121091.1 
DQ343761.1 DQ357223.1 DQ386869.1 DQ386870.1 

4 DOTS entries:

DT.100013795  DT.100013798  DT.100748476  DT.100748477 

7 AceView cDNA sequences:

AY138547 AY223901 AY170469 AY170470 NM_172370 AY138546 AY170471 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for DAOA    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1:              -                             -     -                     
SP2:                                            -     -                     
SP3:                                                                        
SP4:                                      -     -     -                     


ECgene alternative splicing isoforms for DAOA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DAOA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCAAGAAACT

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See DAOA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DAOA

SOURCE GeneReport for Unigene cluster: Hs.381382

UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103
Tissue specificity: Expressed in amygdala, caudate nucleus, spinal cord and testis

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAOA

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for DAOA (if available)
TreeFam Gene Tree for DAOA (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/658 NCBI SNPs in DAOA are shown (see all 658    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 13 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs169666781,2
C,F,H,--86707119(+) TGGACA/GTGGGT 2 -- us2k1 tfbs38Minor allele frequency- G:0.03NA NS EA WA 678
rs1153117221,2
C,F,--86708114(+) CAGTCT/CCNNNN 3 -- us2k11Minor allele frequency- C:0.04WA 118
rs1121032641,2
C,F,--86708136(+) CTCCAT/CGTGGA 3 -- us2k11Minor allele frequency- C:0.01EA 300
rs1112703581,2
F--86709201(+) TGTATA/CTGATG 3 -- int1 ut51 us2k11Minor allele frequency- G:0.01EA 296
rs1131492951,2
F--86709472(+) AGCCCA/CGTATA 3 -- int11Minor allele frequency- C:0.14EA 248
rs1119058101,2
F--86709570(+) CCCTCA/CCCTAT 3 -- int11Minor allele frequency- C:0.10EA 248
rs1136921011,2
F--86709614(+) AATCCA/CCAGCA 3 -- int11Minor allele frequency- C:0.09EA 248
rs1125504681,2
F--86709667(+) CCATCT/CGCCTG 3 -- int11Minor allele frequency- C:0.12EA 248
rs1117652901,2
C,F--86709721(+) ACTGGG/AATAAC 3 -- int12Minor allele frequency- A:0.00EA 492
rs725494671,2
C,F,--86709817(+) AGTGAA/CCTCTC 3 -- int11Minor allele frequency- C:0.03WA 118

HapMap Linkage Disequilibrium report for DAOA (106118216 - 106143383 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for DAOA: --
Human Gene Mutation Database (HGMD): DAOA

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DAOA for disorders           About GeneDecksing

OMIM gene information: 607408   
OMIM disorders: 181500  
8 diseases for DAOA:    About MalaCards
bipolar affective disorder    schizophrenia    bipolar disorder    advanced sleep phase syndrome
childhood-onset schizophrenia    autism spectrum disorder    mood disorder    panic disorder

2 diseases from the University of Copenhagen DISEASES database for DAOA:
Schizophrenia     Schizoaffective disorder

6 Novoseek disease relationships for DAOA gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia 78.4 98 16842973 (6), 19586533 (5), 19237267 (4), 19439994 (4) (see all 31)
bipolar disorder 76.3 26 19689504 (5), 19586533 (4), 19194963 (2), 14966479 (2) (see all 9)
hypofunction 67.1 1 12625025 (1)
psychotic 49.5 5 18466879 (1), 20009237 (1), 17890006 (1)
mood disorders 42.1 2 19089835 (1), 16365481 (1)
psychiatric disorder 24.9 6 19778423 (1), 14966479 (1)

Genetic Association Database (GAD): DAOA
Human Genome Epidemiology (HuGE) Navigator: DAOA (63 documents)

Export disorders for DAOA gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for DAOA gene, integrated from 9 sources (see all 111):
(articles sorted by number of sources associating them with DAOA)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. (PubMed id 12364586)1, 2, 3, 9 Chumakov I.... Cohen D. (2002)
  2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2, 3 Dunham A.... Ross M.T. (2004)
  3. Association of G72/G30 with schizophrenia in the Chinese population. (PubMed id 15194506)1, 4, 9 Wang X....He L. (2004)
  4. Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes. (PubMed id 16263850)1, 4, 9 Schulze T.G....Rietschel M. (2005)
  5. Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified. (PubMed id 15121480)1, 4, 9 Addington A.M....Rapoport J.L. (2004)
  6. Transmission disequilibrium and haplotype analyses of the G72/G30 locus: suggestive linkage to schizophrenia in Palestinian Arabs living in the North of Israel. (PubMed id 16082701)1, 4 Korostishevsky M....Navon R. (2006)
  7. An unappreciated role for RNA surveillance. (PubMed id 14759258)1, 2 Hillman R.T.... Brenner S.E. (2004)
  8. Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis. (PubMed id 15271585)1, 4 Korostishevsky M....Navon R. (2004)
  9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
  10. Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. (PubMed id 12647258)1, 2 Hattori E.... Gershon E.S. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 267012 HGNC: 21191 AceView: DAOA Ensembl:ENSG00000182346 euGenes: HUgn267012
ECgene: DAOA H-InvDB: DAOA

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for DAOA Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for DAOA gene:
Search GeneIP for patents involving DAOA

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

 
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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VWF
(GIFTS: 73)
von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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