DAOA Gene
protein-coding GIFtS : 47
GCID: GC13 P106118
D-amino acid oxidase activator
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Aliasesfor DAOA gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases D-Amino Acid Oxidase Activator 1 2 G72 Transcript2 G721 2 3 5 Schizophrenia- And Bipolar Disorder-Associated Protein G722 LG722 Protein G723 SG722
Export aliases for DAOA gene to outside databases Previous GC identifers: GC13P103816 GC13P104916 GC13P086708
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Summariesfor DAOA gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for DAOA : This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization. Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.(provided by RefSeq, Mar 2011) UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103 Function : Seems to activate D-amino acid oxidase
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Genomic Viewsfor DAOA gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000013.10 NC_018924.1 NT_009952.14 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DAOA gene promoter: GATA-3 Pbx1a MyoD CUTL1 GATA-2 GATA-1 Meis-1b S8 Meis-1a Meis-1 Other transcription factors Search SABiosciences Chromatin IP Primers for DAOA Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAOA
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 13q33.2|13q34 Ensembl cytogenetic band: 13q33.2 HGNC cytogenetic band: 13q33.2 DAOA Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 13 GeneLoc Exon Structure
GeneLoc location for GC13P106118: view genomic region
(about GC identifiers )
Start:
106,118,216 bp from pter
End:
106,143,383 bp from pter
Size:
25,168 bases
Orientation:
plus strand
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Proteinsfor DAOA gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103 (See
protein sequence )Recommended Name: D-amino acid oxidase activator Size : 153 amino acids; 18108 Da
Subunit : Associates with D-amino acid oxidase (DAAO)
Subcellular location : Golgi apparatus
Secondary accessions : A6NKG7 Q0VAE6 Q5VX59 Q86Y17 Q8IWM4Alternative splicing : 4 isoforms : P59103-1 P59103-2 P59103-3 P59103-4 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)Explore the universe of human proteins at neXtProt for DAOA: NX_P59103 DAOA Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (3 alternative transcripts):
NP_001155284.1 NP_001155286.1 NP_758958.3 ENSEMBL proteins: ENSP00000365103 ENSP00000329951 ENSP00000453831 Human Recombinant Protein Products: Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view) : About this table
DAOA for ontologies About GeneDecksing DAOA Antibody Products: Assay Products for DAOA:
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Protein
Domains / Familiesfor DAOA gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section ProtoNet protein and cluster: P59103
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Functionfor DAOA gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103 Function : Seems to activate D-amino acid oxidase
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DAOA (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DAOA (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): DAOA (NM_172370 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DAOA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DAOA
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAOA
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
DAOA for ontologies About GeneDecksing
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Pathways & Interactionsfor DAOA gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAOA STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)2 Interacting proteins for DAOA (P59103 2 , 3 ENSP00000365103 4 ) via UniProtKB, MINT, STRING , and/or I2D About this table Gene Ontology (GO): 2 biological process terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0043085 positive regulation of catalytic activity
IDA 12364586 GO:1900758 negative regulation of D-amino-acid oxidase activity
IDA --
DAOA for ontologies About GeneDecksing
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Drugs & Compoundsfor DAOA gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
DAOA for compounds About GeneDecksing Browse Tocris compounds for DAOA 5 Novoseek chemical compound relationships for DAOA gene About this table
Search CenterWatch for drugs/clinical trials and news about DAOA
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Transcriptsfor DAOA gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DAOA gene (3 alternative transcripts): NM_001161812.1 NM_001161814.1 NM_172370.3 Unigene Cluster for DAOA:
D-amino acid oxidase activator Hs.381382 Unigene Representative Sequence: DQ357223 7 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000489237 ENST00000473269 (uc001vqb.3 ) ENST00000488534 ENST00000375936 ENST00000329625 ENST00000471432 (uc001vqe.3 ) ENST00000559369 (uc010tjf.2 uc001vpz.3 uc010agd.3 uc010tjg.2 uc001vqc.3 )Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DAOA (see all 3 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DAOA (see all 3 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 3 ): DAOA (NM_172370 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DAOA Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DAOA
Additional cDNA sequence: AY138546.1 AY138547.1 AY170469.2 AY170470.2 AY170471.1 AY223901.1 BC121090.1 BC121091.1 DQ343761.1 DQ357223.1 DQ386869.1 DQ386870.1
4 DOTS entries : DT.100013795 DT.100013798
DT.100748476 DT.100748477 7 AceView cDNA sequences :
AY138547 AY223901 AY170469 AY170470 NM_172370 AY138546 AY170471 GeneLoc Exon Structure 4 Alternative Splicing Database (ASD) splice patterns (SP) for DAOA About this scheme ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b SP1 :     -           -   -         SP2 :               -   -         SP3 :                         SP4 :             -   -   -        
ECgene alternative splicing isoforms for DAOA
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Expression for DAOA gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DAOA expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCAAGAAACT
About this image See DAOA Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DAOA SOURCE GeneReport for Unigene cluster: Hs.381382 UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103 Tissue specificity : Expressed in amygdala, caudate nucleus, spinal cord and testis SABiosciences Custom PCR Arrays for DAOA Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DAOABrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat DAOA QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DAOA QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DAOA In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAOA
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Orthologsfor DAOA gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
--
ENSEMBL Gene Tree for DAOA (if available)TreeFam Gene Tree for DAOA (if available)
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Paralogsfor DAOA gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor DAOA gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 13 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DAOA (106118216 - 106143383 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DAOA: -- Human Gene Mutation Database (HGMD) : DAOA SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DAOA
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Disorders
/ Diseasesfor DAOA gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database , Novoseek ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DAOA for disorders About GeneDecksing OMIM gene information: 607408 OMIM disorders : 181500 8 diseases for DAOA : About MalaCards bipolar affective disorder schizophrenia bipolar disorder advanced sleep phase syndrome childhood-onset schizophrenia autism spectrum disorder mood disorder panic disorder 2 diseases from the University of Copenhagen DISEASES database for DAOA :Schizophrenia Schizoaffective disorder 6 Novoseek disease relationships for DAOA gene About this table
Disease
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia
78.4
98
16842973 (6), 19586533 (5), 19237267 (4), 19439994 (4) (see all 31 )
bipolar disorder
76.3
26
19689504 (5), 19586533 (4), 19194963 (2), 14966479 (2) (see all 9 )
hypofunction
67.1
1
12625025 (1)
psychotic
49.5
5
18466879 (1), 20009237 (1), 17890006 (1)
mood disorders
42.1
2
19089835 (1), 16365481 (1)
psychiatric disorder
24.9
6
19778423 (1), 14966479 (1)
Genetic Association Database (GAD): DAOA Human Genome Epidemiology (HuGE) Navigator: DAOA (63 documents) Export disorders for DAOA gene to outside databases
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Publicationsfor DAOA gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DAOA gene, integrated from 9 sources (see all 111 ): (articles sorted by number of sources associating them with DAOA) Utopia : connect your pdf to the dynamic world of online information
Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. (PubMed id 12364586) 1 , 2 , 3, 9 Chumakov I.... Cohen D. (2002) The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823) 1 , 2 , 3 Dunham A.... Ross M.T. (2004) Association of G72/G30 with schizophrenia in the Chinese population. (PubMed id 15194506) 1 , 4, 9 Wang X....He L. (2004) Genotype-phenotype studies in bipolar disorder showing association between the DAOA/G30 locus and persecutory delusions: a first step toward a molecular genetic classification of psychiatric phenotypes. (PubMed id 16263850) 1 , 4, 9 Schulze T.G....Rietschel M. (2005) Polymorphisms in the 13q33.2 gene G72/G30 are associated with childhood-onset schizophrenia and psychosis not otherwise specified. (PubMed id 15121480) 1 , 4, 9 Addington A.M....Rapoport J.L. (2004) Transmission disequilibrium and haplotype analyses of the G72/G30 locus: suggestive linkage to schizophrenia in Palestinian Arabs living in the North of Israel. (PubMed id 16082701) 1 , 4 Korostishevsky M....Navon R. (2006) An unappreciated role for RNA surveillance. (PubMed id 14759258) 1 , 2 Hillman R.T.... Brenner S.E. (2004) Is the G72/G30 locus associated with schizophrenia? single nucleotide polymorphisms, haplotypes, and gene expression analysis. (PubMed id 15271585) 1 , 4 Korostishevsky M....Navon R. (2004) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 1 , 2 Gerhard D.S....Malek J. (2004) Polymorphisms at the G72/G30 gene locus, on 13q33, are associated with bipolar disorder in two independent pedigree series. (PubMed id 12647258) 1 , 2 Hattori E.... Gershon E.S. (2003)
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External Searches for DAOA gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DAOA gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DAOA gene
(According to HUGE )
About This Section --
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Specialized Databases showing DAOA gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for DAOA Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for DAOA gene: Search GeneIP for patents involving DAOA GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DAOA gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for DAOA OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DAOA OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DAOA OriGene Protein Over-expression Lysate for DAOA Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DAOA Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DAOA OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DAOA Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DAOA OriGene Custom Protein Services for DAOA OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DAOA QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DAOA QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAOA QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DAOA QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DAOA QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DAOA
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DAOA Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAOA
ThermoFisher Antibody for DAOA
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DAOA
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Aliases for DAOA
Databases for DAOA
Disorders / Diseases for DAOA
Domains / Families for DAOA
Drugs / Compounds for DAOA
Expression for DAOA
Function for DAOA
Genomic Views for DAOA
Intellectual Property for DAOA
Orthologs for DAOA
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Pathways / Interactions for DAOA
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Variants for DAOA
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