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DAOA Gene

protein-coding   GIFtS: 50
GCID: GC13P106118

D-Amino Acid Oxidase Activator

  See DAOA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
D-Amino Acid Oxidase Activator1 2     SG722
G72 Transcript1 2     Schizophrenia- And Bipolar Disorder-Associated Protein G722
G723 5     Protein G723
LG722     

External Ids:    HGNC: 211911   Entrez Gene: 2670122   Ensembl: ENSG000001823467   OMIM: 6074085   UniProtKB: P591033   

Export aliases for DAOA gene to outside databases

Previous GC identifers: GC13P103816 GC13P104916 GC13P086708


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAOA Gene:
This gene encodes a protein that may function as an activator of D-amino acid oxidase, which degrades the
gliotransmitter D-serine, a potent activator of N-methyl-D-aspartate (NMDA) type glutamate receptors. Studies
also suggest that one encoded isoform may play a role in mitochondrial function and dendritic arborization.
Polymorphisms in this gene have been implicated in susceptibility to schizophrenia and bipolar affective
disorder. Alternatively spliced transcript variants encoding different isoforms have been identified.(provided by
RefSeq, Mar 2011)

GeneCards Summary for DAOA Gene:
DAOA (D-amino acid oxidase activator) is a protein-coding gene. Diseases associated with DAOA include childhood-onset schizophrenia, and bipolar disorder. GO annotations related to this gene include enzyme activator activity and enzyme binding.

UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103
Function: Seems to activate D-amino acid oxidase




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NT_009952.15  NC_018924.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAOA gene promoter:
         GATA-3   Pbx1a   MyoD   CUTL1   GATA-2   GATA-1   Meis-1b   S8   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAOA promoter sequence
   Search Chromatin IP Primers for DAOA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAOA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q33.2|13q34   Ensembl cytogenetic band:  13q33.2   HGNC cytogenetic band: 13q33.2

DAOA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAOA gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13P106118:  view genomic region     (about GC identifiers)

Start:
106,118,216 bp from pter      End:
106,143,383 bp from pter
Size:
25,168 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103 (See protein sequence)
Recommended Name: D-amino acid oxidase activator  
Size: 153 amino acids; 18108 Da
Subunit: Associates with D-amino acid oxidase (DAAO)
Secondary accessions: A6NKG7 Q0VAE6 Q5VX59 Q86Y17 Q8IWM4
Alternative splicing: 4 isoforms:  P59103-1   P59103-2   P59103-3   P59103-4   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DAOA: NX_P59103

Explore proteomics data for DAOA at MOPED


See DAOA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001155284.1  NP_001155286.1  NP_758958.3  

ENSEMBL proteins: 
 ENSP00000453831   ENSP00000472260   ENSP00000470244   ENSP00000471091   ENSP00000365103  
 ENSP00000472676   ENSP00000329951   ENSP00000471306   ENSP00000469539   ENSP00000472857  

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antibodies-online peptides for DAOA

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antibodies-online kits for DAOA (4 products) 


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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1 InterPro protein domain:
 IPR027929 DAOA

Graphical View of Domain Structure for InterPro Entry P59103

ProtoNet protein and cluster: P59103


Find genes that share domains with DAOA           About GenesLikeMe


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DAOA_HUMAN, P59103
Function: Seems to activate D-amino acid oxidase

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0008047enzyme activator activity IDA12364586
GO:0019899enzyme binding IPI12364586
     
Find genes that share ontologies with DAOA           About GenesLikeMe


Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for DAOA

miRNA
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3 qRT-PCR Assays for microRNAs that regulate DAOA:
hsa-miR-374a* hsa-miR-34c-3p hsa-miR-2115
SwitchGear 3'UTR luciferase reporter plasmidDAOA 3' UTR sequence
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAOA


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DAOA_HUMAN, P59103: Golgi apparatus
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
golgi apparatus5
mitochondrion5
nucleus3
peroxisome1

Gene Ontology (GO): 3 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005739mitochondrion IDA--
GO:0005794Golgi apparatus IDA12364586
GO:0048471perinuclear region of cytoplasm IDA--

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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DAOA
Interactions:

    GeneGlobe Interaction Network for DAOA

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for DAOA (P591032, 3 ENSP000003651034) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
DAOP149203, ENSP000002284764I2D: score=1 STRING: ENSP00000228476
--O350782MINT-8204583
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Gene Ontology (GO): 2 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0043085positive regulation of catalytic activity IDA12364586
GO:1900758negative regulation of D-amino-acid oxidase activity IDA--

Find genes that share ontologies with DAOA           About GenesLikeMe



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DAOA

5 Novoseek inferred chemical compound relationships for DAOA gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
nmda 61.8 25 16554747 (2), 17152404 (1), 17492767 (1), 16842973 (1) (see all 13)
glutamate 45.1 10 17250995 (2), 19482054 (1), 17890006 (1), 19439994 (1) (see all 6)
serine 43.5 12 17250995 (2), 19482054 (1), 19591808 (1), 18628682 (1) (see all 8)
dopamine 34.7 1 18988532 (1)
proline 15.5 1 17197372 (1)



Find genes that share compounds with DAOA           About GenesLikeMe



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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REFSEQ mRNAs for DAOA gene (3 alternative transcripts): 
NM_001161812.1  NM_001161814.1  NM_172370.4  

Unigene Cluster for DAOA:

D-amino acid oxidase activator
Hs.381382
Unigene Representative Sequence: DQ357223
10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000559369(uc010tjf.2 uc001vpz.3 uc010agd.3 uc010tjg.2 uc001vqc.3)
ENST00000600388 ENST00000473269(uc001vqb.3) ENST00000488534 ENST00000375936
ENST00000489237 ENST00000329625 ENST00000601240 ENST00000595812 ENST00000471432(uc001vqe.3)

miRNA
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3 qRT-PCR Assays for microRNAs that regulate DAOA:
hsa-miR-374a* hsa-miR-34c-3p hsa-miR-2115
SwitchGear 3'UTR luciferase reporter plasmidDAOA 3' UTR sequence
Inhib. RNA
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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAOA
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  QuantiTect SYBR Green Assays in human, mouse, rat DAOA
  QuantiFast Probe-based Assays in human, mouse, rat DAOA

Additional mRNA sequence: 

AY138546.1 AY138547.1 AY170469.2 AY170470.2 AY170471.1 AY223901.1 BC121090.1 BC121091.1 
DQ343761.1 DQ357223.1 DQ386869.1 DQ386870.1 

4 DOTS entries:

DT.100013795  DT.100013798  DT.100748476  DT.100748477 

7 AceView cDNA sequences:

AY170470 AY170469 AY223901 AY138547 AY138546 AY170471 NM_172370 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for DAOA    About this scheme

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b
SP1:              -                             -     -                     
SP2:                                            -     -                     
SP3:                                                                        
SP4:                                      -     -     -                     


ECgene alternative splicing isoforms for DAOA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DAOA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCAAGAAACT
DAOA Expression
About this image

DAOA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DAOA Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.381382

UniProtKB/Swiss-Prot: DAOA_HUMAN, P59103
Tissue specificity: Expressed in amygdala, caudate nucleus, spinal cord and testis

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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAOA

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and chimp.

Orthologs for DAOA gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chimpanzee
(Pan troglodytes)
Mammalia DAOA1 D-amino acid oxidase activator 92.86(n)
88.78(a)
  100608938  XM_003954418.1  XP_003954467.1 


ENSEMBL Gene Tree for DAOA (if available)
TreeFam Gene Tree for DAOA (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DAOA gene
1 SIMAP similar gene for DAOA using alignment to 5 protein entries:     DAOA_HUMAN (see all proteins):
G72

Find genes that share paralogs with DAOA           About GenesLikeMe



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DAOA (see all 740)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 13 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs23911911,2,,4
C,F,O,Huntested187045225(+) TCAAAA/GGAGCA 4 K R mis1 ut51 ese3111Minor allele frequency- N:0.00NS EA NA PA EU CA WA 9033
rs344608361,2
C--86719514(+) AAAAA-/A/AAA 
        
TTACA
6 -- int1 cds10--------
rs95551741,2
C,H--86729632(+) TCTTTT/CTTTTT 3 -- int1 trp36Minor allele frequency- C:0.00NA WA 12
rs676731551,2
C--86729632(+) TCTTT-/C/CT  
        
TTTTT
3 -- int10--------
rs799035361,2
C,F--87042017(+) TTTACC/TTTCTT 1 -- us2k13Minor allele frequency- T:0.06EA NA 540
rs1884095391,2
--87042025(+) CTTTCC/TTCTCC 1 -- us2k10--------
rs1462210071,2
--87042119(+) GAGTTC/TCAGGA 1 -- us2k10--------
rs1484207451,2
C--87042170(+) TTACTC/TCAGTG 2 -- us2k10--------
rs1172924181,2
F--87042217(+) AGACTC/ATGATT 2 -- us2k11Minor allele frequency- A:0.01NA 120
rs1164403411,2
F--87042229(+) ATTATG/ACAAGA 2 -- us2k11Minor allele frequency- A:0.01WA 118

HapMap Linkage Disequilibrium report for DAOA (106118216 - 106143383 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for DAOA:    About this table    
Variant IDTypeSubtypePubMed ID
nsv519018CNV Loss19592680
esv275034CNV Gain+Loss21479260

Human Gene Mutation Database (HGMD): DAOA
Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DAOA
DNA2.0 Custom Variant and Variant Library Synthesis for DAOA

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 607408   
OMIM disorders: 181500  
3 diseases for DAOA:    
About MalaCards
childhood-onset schizophrenia    bipolar disorder    schizophrenia

2 diseases from the University of Copenhagen DISEASES database for DAOA:
Schizophrenia     Schizoaffective disorder

Find genes that share disorders with DAOA           About GenesLikeMe

6 Novoseek inferred disease relationships for DAOA gene    About this table

Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
schizophrenia 78.4 98 16842973 (6), 19586533 (5), 19237267 (4), 19439994 (4) (see all 31)
bipolar disorder 76.3 26 19689504 (5), 19586533 (4), 19194963 (2), 14966479 (2) (see all 9)
hypofunction 67.1 1 12625025 (1)
psychotic 49.5 5 18466879 (1), 20009237 (1), 17890006 (1)
mood disorders 42.1 2 19089835 (1), 16365481 (1)
psychiatric disorder 24.9 6 19778423 (1), 14966479 (1)

Genetic Association Database (GAD): DAOA
Human Genome Epidemiology (HuGE) Navigator: DAOA (63 documents)

Export disorders for DAOA gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DAOA gene, integrated from 10 sources (see all 126):
(articles sorted by number of sources associating them with DAOA)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Genetic and physiological data implicating the new human gene G72 and the gene for D-amino acid oxidase in schizophrenia. (PubMed id 12364586)1, 2, 3, 9 Chumakov I.... Cohen D. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  2. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2, 3 Dunham A.... Ross M.T. (Nature 2004)
  3. Effect of the G72 (DAOA) putative risk haplotype on cognitive functions in healthy subjects. (PubMed id 19778423)1, 4, 9 Jansen A....Kircher T. (BMC Psychiatry 2009)
  4. Genetic variation in the DAOA (G72) gene modulates hippocampal function in subjects at high risk of schizophrenia. (PubMed id 18423426)1, 4, 9 Hall J....Johnstone E.C. (Biol. Psychiatry 2008)
  5. Common and rare variants of DAOA in bipolar disorder. (PubMed id 19194963)1, 4, 9 Maheshwari M....Gibbs R.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2009)
  6. Association study of the G72 gene with schizophrenia in a Japanese population: a multicenter study. (PubMed id 19237267)1, 4, 9 Ohi K....Takeda M. (Schizophr. Res. 2009)
  7. Genetic variation in the G72 (DAOA) gene affects temporal lobe and amygdala structure in subjects affected by bipolar disorder. (PubMed id 19689504)1, 4, 9 Zuliani R....McIntosh A.M. (Bipolar Disord 2009)
  8. Genetic variation in the DAOA gene complex: impact on susceptibility for schizophrenia and on cognitive performance. (PubMed id 18541412)1, 4, 9 Opgen-Rhein C....Malhotra A.K. (Schizophr. Res. 2008)
  9. G72 gene is associated with susceptibility to methamphetamine psychosis. (PubMed id 19482054)1, 4, 9 Kotaka T....Kuroda S. (amp 2009)
  10. No association of G72 and D-amino acid oxidase genes with schizophrenia. (PubMed id 16842973)1, 4, 9 Liu Y.L....Hwu H.G. (Schizophr. Res. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Disorders
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 267012 HGNC: 21191 AceView: DAOA Ensembl:ENSG00000182346 euGenes: HUgn267012
ECgene: DAOA H-InvDB: DAOA

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DAOA Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DAOA gene:
Search GeneIP for patents involving DAOA

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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