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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAO Gene

protein-coding   GIFtS: 64
GCID: GC12P109273

D-amino-acid oxidase
 Explore 15 diseases affiliated with
DAO via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DAO    

Aliases
for DAO gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
D-Amino-Acid Oxidase1 2     OXDA2
DAMOX1 2 3 5     D-Amino Acid Oxidase2
DAAO2 3     EC 1.4.38
EC 1.4.3.33 8     

External Ids:    HGNC: 26711   Entrez Gene: 16102   Ensembl: ENSG000001108877   OMIM: 1240505   UniProtKB: P149203   

Export aliases for DAO gene to outside databases

Previous GC identifers: GC12U990015 GC12P109154 GC12P107776 GC12P106338


Summaries
for DAO gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DAO:
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine
dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive
on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent
which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA
receptor. This gene may play a role in the pathophysiology of schizophrenia. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: OXDA_HUMAN, P14920
Function: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and
contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during
aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by
those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids




Genomic Views
for DAO gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.1  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAO gene promoter:
         GR   USF1   MAZR   USF-1   GR-beta   c-Myb   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DAO promoter sequence
   Search SABiosciences Chromatin IP Primers for DAO

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q24.11   HGNC chromosome: 12

DAO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAO gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P109273:  view genomic region     (about GC identifiers)

Start:
 109,252,708 bp from pter      End:
 109,294,819 bp from pter
Size:
 42,112 bases      Orientation:
 plus strand

Proteins
for DAO gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: OXDA_HUMAN, P14920 (See protein sequence)
Recommended Name: D-amino-acid oxidase  
Size: 347 amino acids; 39474 Da
Cofactor: FAD
Subunit: Homodimer
Subcellular location: Peroxisome
6/8 PDB 3D structures from and Proteopedia for DAO (see all 8):
2DU8 (3D)        2E48 (3D)        2E49 (3D)        2E4A (3D)        2E82 (3D)        2GNZ (3D)    
Secondary accessions: B2R7I5 Q16758 Q8N6R2

Explore the universe of human proteins at neXtProt for DAO: NX_P14920

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P14920

    • 4/10 DME Specific Peptides for DAO (P14920) (see all 10)
     YADRFTP  TGFRPVR  NCTGVWA  ERYHSVLQ 

    DAO Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001908.3  
    ENSEMBL proteins: 
     ENSP00000446853   ENSP00000228476   ENSP00000448095   ENSP00000449967   ENSP00000449248  
     ENSP00000447104  
    Reactome Protein details: P14920
    Human Recombinant Protein Products: 
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    ProSpec Recombinant Protein for DAO
    Uscn Proteins for DAO

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741colocalizes with mitochondrial outer membrane IDA--
    GO:0005777peroxisome IDA18544534
    GO:0005778peroxisomal membrane IDA--
    GO:0005782peroxisomal matrix TAS--
    GO:0005829cytosol IDA--


    DAO for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DAO

    Protein Domains /
    Families
    for DAO gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DAO for domains           About GeneDecksing

    3 InterPro domains/families:
     IPR006076 FAD-dep_OxRdtase
     IPR006181 D-amino_acid_oxidase_CS
     IPR023209 D-aa_oxidase

    Graphical View of Domain Structure for InterPro Entry P14920

    ProtoNet protein and cluster: P14920

    1 Blocks protein family: IPB006181 D-amino acid oxidase

    UniProtKB/Swiss-Prot: OXDA_HUMAN, P14920
    Similarity: Belongs to the DAMOX/DASOX family


    Function
    for DAO gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: OXDA_HUMAN, P14920
    Function: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and
    contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during
    aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by
    those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids
    Catalytic activity: A D-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2)
    Biophysicochemical properties: Kinetic parameters: KM=3.6 mM for D-serine; KM=1.7 mM for D-proline; KM=1.1 mM for
    D-tyrosine; KM=1.5 mM for D-DOPA; KM=1.2 mM for D-phenylalanine; KM=0.9 mM for D-alanine;

         Genatlas biochemistry entry for DAO:
    D-amino-oxidase,glycine oxidase catalyzing the synthesis of glyoxylate,peroxisomal

    Enzyme Numbers (IUBMB): EC 1.4.3.31 2 EC 1.4.32

    miRNA
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    3 QIAGEN miScript miRNA Assays for microRNAs that regulate DAO:
    hsa-miR-4303 hsa-miR-1286 hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmid: DAO 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: DAO
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    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DAO

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAO (see all 3)
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    In Situ Assay
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    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003884D-amino-acid oxidase activity TAS--
    GO:0005102receptor binding IPI--
    GO:0005515protein binding IPI--
    GO:0016641oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor ----


    DAO for ontologies           About GeneDecksing


    Animal Models:
         3 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dao):
     behavior/neurological  homeostasis/metabolism  nervous system 

    DAO for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DAO gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Metabolism
    		Metabolism1.00
    		Metabolic pathways0.38
    2Metabolism of amino acids and derivatives
    		Metabolism of amino acids and derivatives1.00
    3Peroxisome
    		Peroxisome1.00
    4D-Arginine and D-ornithine metabolism
    		D-Arginine and D-ornithine metabolism1.00
    5Arginine and proline metabolism
    		Arginine and proline metabolism1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    3        Reactome Pathways for DAO
        Glyoxylate metabolism
    Metabolism
    Metabolism of amino acids and derivatives


    5         Kegg Pathways  (Kegg details for DAO):
        Glycine, serine and threonine metabolism
    Arginine and proline metabolism
    D-Arginine and D-ornithine metabolism
    Metabolic pathways
    Peroxisome


    DAO for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 20)

    5/20 Interacting proteins for DAO (P149203 ENSP000002284764) via UniProtKB, MINT, STRING, and/or I2D (see all 20)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ABP1P198013, ENSP000003541934I2D: score=1 STRING: ENSP00000354193
    DAOAP591033, ENSP000003651034I2D: score=1 STRING: ENSP00000365103
    AGXTENSP000003026204STRING: ENSP00000302620
    GATMENSP000003798954STRING: ENSP00000379895
    GLDCENSP000003707374STRING: ENSP00000370737
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006551leucine metabolic process IEA--
    GO:0006562proline catabolic process IDA16616139
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0036088D-serine catabolic process IDA18544534
    GO:0042416dopamine biosynthetic process IDA17303072


    DAO for ontologies           About GeneDecksing



    Drugs & Compounds
    for DAO gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DAO for compounds           About GeneDecksing

    EMD Millipore small molecules for DAO:
    Small Molecule - inhibitor
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    Browse Tocris compounds for DAO

    10/16 HMDB Compounds for DAO (see all 16)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Pyrroline-2-carboxylic acid3,4-dihydro-2H-pyrrole-5-carboxylic acid (see all 7)2139-03-9--
    1-Pyrroline-4-hydroxy-2-carboxylate4-hydroxy-1-pyrroline-2-carboxylate (see all 2)9054-77-7--
    4-Hydroxy-L-prolineL-4-hydroxy-proline (see all 11)30724-02-8--
    5-Amino-2-oxopentanoic acid2-Oxo-5-amino-pentanoate (see all 9)----
    AmmoniaNH3 (see all 31)7664-41-7--
    D-AlanineD-2-Aminopropionic acid (see all 12)338-69-2--
    D-ArginineD-2-Amino-5-guanidinovalerate (see all 2)157-06-2--
    D-Ornithine(2R)-2,5-diaminopentanoate (see all 4)348-66-3--
    D-ProlineR-Proline (see all 8)344-25-2--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--

    8 DrugBank Compounds for DAO    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-Aminobenzoic Acid-- --target--17139284 17016423 10592235
    3,4-Dihydro-2h-Pyrrolium-5-Carboxylate-- --target--17139284 17016423 10592235
    Benzoic Acid-- 65-85-0target--17139284 17016423 10592235
    D-Tryptophan-- 153-94-6target--17139284 17016423 10592235
    Flavin-Adenine Dinucleotide-- 146-14-5target--17139284 17016423 10592235
    Flavin-Adenine Dinucleotide-N5-Isobutyl Ketone-- --target--17139284 17016423 10592235
    (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID-- --target--10592235
    Imino-Tryptophan-- --target--10592235

    10/43 Novoseek chemical compound relationships for DAO gene (see all 43)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutaryl-7-aminocephalosporanic acid 76.9 6 15269545 (2), 10972935 (1), 16809100 (1)
    7-aminocephalosporanic acid 76.7 11 15269545 (3), 12024974 (2), 10972935 (1), 16809100 (1)
    flavin 74.3 38 9153426 (3), 17088322 (3), 8690726 (3), 10716694 (2) (see all 14)
    cephalosporin c 70.2 6 15269545 (3), 16809100 (1)
    pipecolic acid 69 5 11330064 (3), 8892018 (1)
    serine 67 131 20091774 (7), 17880399 (6), 19088300 (5), 15953485 (3) (see all 36)
    nmda 66.9 41 19685198 (2), 12364586 (2), 18378121 (2), 17880399 (1) (see all 20)
    trigonelline 61.8 8 1975807 (3), 10920257 (1)
    alpha-ketoisovalerate 60.9 2 1682335 (1), 9153426 (1)
    cerium 59.9 4 1682047 (2), 1347269 (1), 7907383 (1)

    Search CenterWatch for drugs/clinical trials and news about DAO / OXDA 

    Transcripts
    for DAO gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DAO gene: 
    NM_001917.4  

    Unigene Cluster for DAO:

    D-amino-acid oxidase
    Hs.113227  [show with all ESTs]
    Unigene Representative Sequence: NM_001917
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548052(uc001tnp.1) ENST00000551281(uc001tnq.4) ENST00000228476(uc001tnr.4 uc009zvb.3 uc001tns.4)
    ENST00000547122 ENST00000547768 ENST00000549215 ENST00000547166 ENST00000546552


    miRNA
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    hsa-miR-4303 hsa-miR-1286 hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmid: DAO 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: DAO (NM_001917)
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    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAO

    Additional cDNA sequence: 

    AK312995.1 BC029057.1 BC074770.2 BX538210.1 

    4 DOTS entries:

    DT.406423  DT.101980700  DT.92419491  DT.95086560 

    24/38 AceView cDNA sequences (see all 38):

    AV727558 AX776479 AX776478 BE463940 BM717775 BX538210 AI478185 AX776480 
    BM685098 BC074770 BC029057 BF115205 AI791352 BX115127 AX786386 AI470939 
    AW779822 AA953563 BE463682 AW299997 BF592003 NM_001917 AI732956 BM679799 

    GeneLoc Exon Structure


    Expression
    for DAO gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: AGTCTTCAGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image
    See DAO Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAO

    SOURCE GeneReport for Unigene cluster: Hs.113227
        SABiosciences Expression via Pathway-Focused PCR Arrays including DAO: 
              Amino Acid Metabolism II in human mouse rat
              Amino Acid Metabolism I in human mouse rat

    Primer
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    In Situ
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    Orthologs
    for DAO gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DAO gene from 7/22 species (see all 22)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dao1 , 5 D-amino acid oxidase1, 5 82.13(n)1
    80.87(a)1    		   5 (55.93 cM)5
    131421  NM_010018.21  NP_034148.21 
     1140037035 
    chicken
    (Gallus gallus)    		 Aves DAO6
    		 Uncharacterized protein
    		 64(a)
    		 1 ↔ 1
    		 15(6753503-6758097)
    lizard
    (Anolis carolinensis)    		 Reptilia DAO6
    		 --
    		 67(a)
    		 1 ↔ 1
    		 AAWZ02038198(5162-6444)
    tropical clawed frog
    (Xenopus tropicalis)    		 Amphibia Str.120032 Transcribed sequence with weak similarity to protein more 79.2(n)    AL971101.2 
    zebrafish
    (Danio rerio)    		 Actinopterygii dao.16
    dao.26
    (see all 3)    		 D-amino-acid oxidase 2
    (see all 3)    		 59(a)
    59(a)
    (see all 3)    		 many → 1
    many → 1
    (see all 3)    		 5(21971766-21978678)
    5(21954288-21968993)
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG112363 D-aspartate oxidase 31(a)   27B1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea Y69A2AR.53   -- 34(a)   IV(2614205-2617036)   --


    ENSEMBL Gene Tree for DAO (if available)
    TreeFam Gene Tree for DAO (if available) 

    Paralogs
    for DAO gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DAO gene
    DDO2  
    3 SIMAP similar genes for DAO using alignment to 4 protein entries:     OXDA_HUMAN (see all proteins):
    DKFZp686F04272    DDO    ddo

    DAO for paralogs           About GeneDecksing



    Genomic Variants
    for DAO gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/539 NCBI SNPs in DAO are shown (see all 539)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 12 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs784228051,2
    		F,--106336486(+) GAAAAA/CAATAA 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs775214941,2
    		--106336552(+) CGTAAA/CTTATT 1 -- us2k10--------
    rs769452681,2
    		C,F,--106336760(+) TGAAGA/GAAAAA 1 -- us2k13Minor allele frequency- G:0.16WA 122
    rs765619941,2
    		F,--106336827(+) GGTGGG/AATGAT 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs788770991,2
    		F,--106336900(+) AGTAAG/ATAATT 1 -- us2k11Minor allele frequency- A:0.05WA 118
    rs1137291571,2
    		--106337427(+) TGTAGC/TCCAGG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs1125487601,2
    		F--106337659(+) TGTCAG/AAATTA 1 -- us2k11Minor allele frequency- A:0.01EA 286
    rs761180041,2
    		--106337691(+) AGCCGA/GCCCTC 1 -- us2k11Minor allele frequency- G:0.01EA 120
    rs734109441,2
    		C,--106337711(+) AGGAAA/GAAATA 1 -- us2k12Minor allele frequency- G:0.13WA 120
    rs764124001,2
    		--106337748(+) TTTCTC/TATTTC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DAO (109252708 - 109294819 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DAO
         1 CNV: 5312
    Human Gene Mutation Database (HGMD): DAO

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DAO
    DNA2.0 Custom Variant and Variant Library Synthesis for DAO

    Disorders / Diseases
    for DAO gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DAO for disorders           About GeneDecksing

    OMIM gene information: 124050   
    OMIM disorders: 181500  
    15 diseases for DAO:    About MalaCards
    schizophrenia    bipolar affective disorder    autism spectrum disorder    zellweger syndrome
    primary hyperoxaluria    amyotrophic lateral sclerosis    bipolar i disorder    lateral sclerosis
    bipolar disorder    crohn's disease    cholesterol    retinitis
    tuberculosis    neuronitis    mycobacterium tuberculosis

    2 diseases from the University of Copenhagen DISEASES database for DAO:
    Schizophrenia     Bipolar I disorder

    9 Novoseek disease relationships for DAO gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypofunction 74.6 2 12625025 (1), 18378121 (1)
    schizophrenia 74 164 17492767 (7), 18378121 (7), 16842973 (6), 19786963 (5) (see all 42)
    bipolar disorder 52.7 11 18165970 (3), 14966479 (2), 18378121 (2), 19586533 (1) (see all 6)
    zellweger syndrome 44.2 1 11330064 (1)
    tumors 5.51 2 19694805 (1), 14735461 (1)
    nephrotic syndrome 2.15 3 9582550 (2)
    psychiatric disorder 2.07 2 16183301 (1)
    renal disease 0 2 8496288 (1), 9582550 (1)
    cancer 0 4 19694805 (2), 15651667 (1), 12564842 (1)

    Genetic Association Database (GAD): DAO
    Human Genome Epidemiology (HuGE) Navigator: DAO (57 documents)

    Export disorders for DAO gene to outside databases

    Publications
    for DAO gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAO gene, integrated from 9 sources (see all 189):
    (articles sorted by number of sources associating them with DAO)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal localization of a human gene encoding D-amino-acid oxidase. (PubMed id 1356107)1, 2, 3, 9 Fukui K. and Miyake Y. (1992)
    2. Crystal structure of human D-amino acid oxidase: context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring. (PubMed id 17088322)1, 2, 9 Kawazoe T....Fukui K. (2006)
    3. Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis. (PubMed id 17303072)1, 2, 9 Kawazoe T.... Fukui K. (2007)
    4. Association of DAAO with schizophrenia in the Chinese population. (PubMed id 15464270)1, 4, 9 Liu X....He L. (2004)
    5. Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. (PubMed id 16380905)1, 4, 9 Fallin M.D....Pulver A.E. (2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. The human gene for diamine oxidase, an amiloride binding protein. Molecular cloning, sequencing, and characterization of the promoter. (PubMed id 8182053)1, 3 Chassande O.... Lazdunski M. (1994)
    8. Molecular cloning and sequence analysis of cDNA encoding human kidney D-amino acid oxidase. (PubMed id 2901986)1, 2 Momoi K.... Miyake Y. (1988)
    9. Potential pathophysiological role of D-amino acid oxi dase in schizophrenia: immunohistochemical and in situ hybridization study of t he expression in human and rat brain. (PubMed id 19685198)1, 9 Ono K....Fukui K. (2009)
    10. D-amino acid oxidase (DAO) genotype and mood symptomatology in schizophrenia. (PubMed id 17890006)1, 9 Corvin A....Gill M. (2007)

    External Searches for DAO gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DAO gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1610 HGNC: 2671 AceView: DAO Ensembl:ENSG00000110887 euGenes: HUgn1610
    ECgene: DAO Kegg: 1610 H-InvDB: DAO

    Other Databases showing DAO gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DAO gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAO Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DAO gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DAO gene:
    Search GeneIP for patents involving DAO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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