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DAO Gene

protein-coding   GIFtS: 64
GCID: GC12P109273

D-Amino-Acid Oxidase

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
D-Amino-Acid Oxidase1 2     OXDA2
DAMOX2 3 5     D-Amino Acid Oxidase2
DAAO2 3     EC 1.4.38
EC 1.4.3.33 8     

External Ids:    HGNC: 26711   Entrez Gene: 16102   Ensembl: ENSG000001108877   OMIM: 1240505   UniProtKB: P149203   
ORGUL members:         

Export aliases for DAO gene to outside databases

Previous GC identifers: GC12U990015 GC12P109154 GC12P107776 GC12P106338


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAO Gene:
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin
adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but
it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a
detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a
co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. (provided by
RefSeq, Jul 2008)

GeneCards Summary for DAO Gene:
DAO (D-amino-acid oxidase) is a protein-coding gene. Diseases associated with DAO include bipolar i disorder, and primary hyperoxaluria. GO annotations related to this gene include cofactor binding and receptor binding. An important paralog of this gene is DDO.

UniProtKB/Swiss-Prot: OXDA_HUMAN, P14920
Function: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and
contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated
during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains
followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000012.12  NT_029419.13  NC_018923.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAO gene promoter:
         GR   USF1   MAZR   USF-1   GR-beta   c-Myb   GR-alpha   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAO promoter sequence
   Search Chromatin IP Primers for DAO

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAO


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q24   Ensembl cytogenetic band:  12q24.11   HGNC cytogenetic band: 12q24.11

DAO Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAO gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12P109273:  view genomic region     (about GC identifiers)

Start:
109,252,708 bp from pter      End:
109,294,819 bp from pter
Size:
42,112 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: OXDA_HUMAN, P14920 (See protein sequence)
Recommended Name: D-amino-acid oxidase  
Size: 347 amino acids; 39474 Da
Cofactor: FAD
Subunit: Homodimer
Selected PDB 3D structures from and Proteopedia for DAO (see all 15):
2DU8 (3D)        2E48 (3D)        2E49 (3D)        2E4A (3D)        2E82 (3D)        2GNZ (3D)    
Secondary accessions: B2R7I5 Q16758 Q8N6R2

Explore the universe of human proteins at neXtProt for DAO: NX_P14920

Explore proteomics data for DAO at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for DAO (P14920) (see all 10)
     YADRFTP  TGFRPVR  NCTGVWA  ERYHSVLQ 


    See DAO Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_001908.3  
    ENSEMBL proteins: 
     ENSP00000446853   ENSP00000228476   ENSP00000448095   ENSP00000449967   ENSP00000449248  
     ENSP00000447104  
    Reactome Protein details: P14920

    DAO Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for DAO
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    Novus Biologicals DAO Proteins
    Browse Sino Biological Recombinant Proteins
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    ProSpec Recombinant Protein for DAO
    Cloud-Clone Corp. Proteins for DAO

    DAO Antibody Products:

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    LSBio Antibodies in human, mouse, rat for DAO

    DAO Assay Products:

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    GenScript Custom Assay Services for DAO
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DAO
    Cloud-Clone Corp. CLIAs for DAO


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR006076 FAD-dep_OxRdtase
     IPR006181 D-amino_acid_oxidase_CS
     IPR023209 D-aa_oxidase

    Graphical View of Domain Structure for InterPro Entry P14920

    ProtoNet protein and cluster: P14920

    1 Blocks protein domain: IPB006181 D-amino acid oxidase

    UniProtKB/Swiss-Prot: OXDA_HUMAN, P14920
    Similarity: Belongs to the DAMOX/DASOX family


    DAO for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: OXDA_HUMAN, P14920
    Function: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and
    contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated
    during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains
    followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids
    Catalytic activity: A D-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2)
    Biophysicochemical properties: Kinetic parameters: KM=3.6 mM for D-serine; KM=1.7 mM for D-proline; KM=1.1 mM for
    D-tyrosine; KM=1.5 mM for D-DOPA; KM=1.2 mM for D-phenylalanine; KM=0.9 mM for D-alanine;

         Genatlas biochemistry entry for DAO:
    D-amino-oxidase,glycine oxidase catalyzing the synthesis of glyoxylate,peroxisomal

         Enzyme Numbers (IUBMB): EC 1.4.3.31 2 EC 1.4.32

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003884D-amino-acid oxidase activity TAS--
    GO:0005102receptor binding IPI--
    GO:0005515protein binding IPI12364586
    GO:0016491oxidoreductase activity ----
    GO:0016641oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor ----
         
    DAO for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dao):
     behavior/neurological  homeostasis/metabolism  nervous system 

    DAO for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DAO
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DAO

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DAO
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAO

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat DAO using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate DAO:
    hsa-miR-4303 hsa-miR-1286 hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidDAO 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DAO
    Predesigned siRNA for gene silencing in human, mouse, rat DAO

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DAO

    Clone
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    OriGene clones in human, mouse for DAO (see all 7)
    OriGene ORF clones in mouse, rat for DAO
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DAO (NM_001917)
    Sino Biological Human cDNA Clone for DAO
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAO

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DAO 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAO


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    OXDA_HUMAN, P14920: Peroxisome
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol5
    peroxisome5
    extracellular2
    endoplasmic reticulum1
    lysosome1
    mitochondrion1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741colocalizes with mitochondrial outer membrane IDA--
    GO:0005777peroxisome IDA18544534
    GO:0005778peroxisomal membrane IDA--
    GO:0005782peroxisomal matrix TAS--
    GO:0005829cytosol IDA--

    DAO for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAO About    
    See pathways by source

    SuperPathContained pathways About
    1Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    Glyoxylate metabolism0.00
    D-Arginine and D-ornithine metabolism0.00
    2Metabolism
    Metabolism0.38
    Metabolic pathways0.38
    3Peroxisome
    Peroxisome
    4Glycine, serine and threonine metabolism
    Glycine, serine and threonine metabolism
    5Arginine and proline metabolism
    Arginine and proline metabolism

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for DAO
        Glyoxylate metabolism


    5 Kegg Pathways  (Kegg details for DAO):
        Glycine, serine and threonine metabolism
    Arginine and proline metabolism
    D-Arginine and D-ornithine metabolism
    Metabolic pathways
    Peroxisome


    DAO for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including DAO: 
              Amino Acid Metabolism II in human mouse rat
              Amino Acid Metabolism I in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DAO

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    Selected Interacting proteins for DAO (P149203 ENSP000002284764) via UniProtKB, MINT, STRING, and/or I2D (see all 23)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    AOC1P198013, ENSP000003541934I2D: score=1 STRING: ENSP00000354193
    DAOAP591033, ENSP000003651034I2D: score=1 STRING: ENSP00000365103
    AGXTENSP000003026204STRING: ENSP00000302620
    GATMENSP000003798954STRING: ENSP00000379895
    GLDCENSP000003707374STRING: ENSP00000370737
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006551leucine metabolic process IEA--
    GO:0006562proline catabolic process IDA16616139
    GO:0034641cellular nitrogen compound metabolic process TAS--
    GO:0036088D-serine catabolic process IDA18544534
    GO:0042416dopamine biosynthetic process IDA17303072

    DAO for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAO (OXDA)

    Selected HMDB Compounds for DAO (see all 16)    About this table
    CompoundSynonyms CAS #PubMed Ids
    1-Pyrroline-2-carboxylic acid3,4-dihydro-2H-pyrrole-5-carboxylic acid (see all 7)2139-03-9--
    1-Pyrroline-4-hydroxy-2-carboxylate4-hydroxy-1-pyrroline-2-carboxylate (see all 2)9054-77-7--
    4-Hydroxy-L-prolineL-4-hydroxy-proline (see all 11)30724-02-8--
    5-Amino-2-oxopentanoic acid2-Oxo-5-amino-pentanoate (see all 9)----
    AmmoniaNH3 (see all 31)7664-41-7--
    D-AlanineD-2-Aminopropionic acid (see all 12)338-69-2--
    D-ArginineD-2-Amino-5-guanidinovalerate (see all 2)157-06-2--
    D-Ornithine(2R)-2,5-diaminopentanoate (see all 4)348-66-3--
    D-ProlineR-Proline (see all 8)344-25-2--
    FAD1H-Purin-6-amine flavin dinucleotide (see all 21)146-14-5--

    8 DrugBank Compounds for DAO    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    2-Aminobenzoic Acid-- --target--17139284 17016423 10592235
    3,4-Dihydro-2h-Pyrrolium-5-Carboxylate-- --target--17139284 17016423 10592235
    Benzoic Acid-- 65-85-0target--17139284 17016423 10592235
    D-Tryptophan-- 153-94-6target--17139284 17016423 10592235
    Flavin-Adenine Dinucleotide-- 146-14-5target--17139284 17016423 10592235
    Flavin-Adenine Dinucleotide-N5-Isobutyl Ketone-- --target--17139284 17016423 10592235
    (2E)-3-(3,4-DIHYDROXYPHENYL)-2-IMINOPROPANOIC ACID-- --target--10592235
    Imino-Tryptophan-- --target--10592235

    Selected Novoseek inferred chemical compound relationships for DAO gene (see all 43)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    glutaryl-7-aminocephalosporanic acid 76.9 6 15269545 (2), 10972935 (1), 16809100 (1)
    7-aminocephalosporanic acid 76.7 11 15269545 (3), 12024974 (2), 10972935 (1), 16809100 (1)
    flavin 74.3 38 9153426 (3), 17088322 (3), 8690726 (3), 10716694 (2) (see all 14)
    cephalosporin c 70.2 6 15269545 (3), 16809100 (1)
    pipecolic acid 69 5 11330064 (3), 8892018 (1)
    serine 67 131 20091774 (7), 17880399 (6), 19088300 (5), 15953485 (3) (see all 36)
    nmda 66.9 41 19685198 (2), 12364586 (2), 18378121 (2), 17880399 (1) (see all 20)
    trigonelline 61.8 8 1975807 (3), 10920257 (1)
    alpha-ketoisovalerate 60.9 2 1682335 (1), 9153426 (1)
    cerium 59.9 4 1682047 (2), 1347269 (1), 7907383 (1)



    DAO for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DAO gene: 
    NM_001917.4  

    Unigene Cluster for DAO:

    D-amino-acid oxidase
    Hs.113227  [show with all ESTs]
    Unigene Representative Sequence: NM_001917
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000548052(uc001tnp.1) ENST00000551281(uc001tnq.4) ENST00000228476(uc001tnr.4 uc009zvb.3 uc001tns.4)
    ENST00000547122 ENST00000547768 ENST00000549215 ENST00000547166 ENST00000546552

    miRNA
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    3 qRT-PCR Assays for microRNAs that regulate DAO:
    hsa-miR-4303 hsa-miR-1286 hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidDAO 3' UTR sequence
    Inhib. RNA
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    Clone
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    GenScript: all cDNA clones in your preferred vector: DAO (NM_001917)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAO
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAO
    Primer
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    OriGene qPCR primer pairs and template standards for DAO
    OriGene qSTAR qPCR primer pairs in human, mouse for DAO
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DAO
      QuantiTect SYBR Green Assays in human, mouse, rat DAO
      QuantiFast Probe-based Assays in human, mouse, rat DAO

    Additional mRNA sequence: 

    AK312995.1 BC029057.1 BC074770.2 BX538210.1 

    4 DOTS entries:

    DT.406423  DT.101980700  DT.92419491  DT.95086560 

    Selected AceView cDNA sequences (see all 38):

    BM717775 AI478185 BF115205 AX786386 AI470939 AV727558 BX115127 BX538210 
    AX776478 BE463940 BM685098 BC029057 AX776480 AX776479 BC074770 AI791352 
    BX488551 BF592003 AW299997 BE463682 AI732956 AW779822 BM679799 NM_001917 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    DAO expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AGTCTTCAGA
    DAO Expression
    About this image


    DAO expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Cerebellum
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Kidney (Urinary System)
             Metanephros
    DAO Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAO Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.113227
        Pathway & Disease-focused RT2 Profiler PCR Arrays including DAO: 
              Amino Acid Metabolism II in human mouse rat
              Amino Acid Metabolism I in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DAO
    OriGene qSTAR qPCR primer pairs in human, mouse for DAO
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DAO
    QuantiTect SYBR Green Assays in human, mouse, rat DAO
    QuantiFast Probe-based Assays in human, mouse, rat DAO
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAO

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for DAO gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dao1 , 5 D-amino acid oxidase1, 5 82.13(n)1
    80.87(a)1
      5 (55.93 cM)5
    131421  NM_001286396.11  NP_001273325.11 
     1140037035 
    lizard
    (Anolis carolinensis)
    Reptilia DAO6
    D-amino-acid oxidase
    67(a)
    1 ↔ 1
    AAWZ02038198(1792-12558)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.120032 Transcribed sequence with weak similarity to protein more 79.2(n)    AL971101.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dao.31 D-amino-acid oxidase, tandem duplicate 3 64(n)
    62.02(a)
      402994  NM_205694.1  NP_991257.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG112361 , 3 D-aspartate oxidase3
    CG112361
    31(a)3
    44.98(n)1
    33.33(a)1
      27B13
    339551  NM_135231.31  NP_609075.11 
    worm
    (Caenorhabditis elegans)
    Secernentea Y69A2AR.53   -- 34(a)   IV(2614205-2617036)   --
    K. lactis yeast
    (Kluyveromyces lactis)
    Saccharomycetes KLLA0A08492g1 KLLA0A08492g 38.46(n)
    28(a)
      2896313  XM_451375.1  XP_451375.1 


    ENSEMBL Gene Tree for DAO (if available)
    TreeFam Gene Tree for DAO (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAO gene
    DDO2  
    3 SIMAP similar genes for DAO using alignment to 4 protein entries:     OXDA_HUMAN (see all proteins):
    DKFZp686F04272    DDO    ddo

    DAO for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAO (see all 653)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs106899511,2
    C,F--106339015(+) CAAAT-/AACAACTT 1 -- cds12Minor allele frequency- AAC:0.50NA CSA 4
    rs3701434351,2
    C--106339017(+) AAATA-/AACACTTC 1 -- cds10--------
    rs784228051,2
    F--109113155(+) GAAAAA/CAATAA 1 -- us2k11Minor allele frequency- C:0.05WA 118
    rs108619731,2
    C,F,A,H--109113203(+) ACACCA/GCAATT 1 -- us2k122Minor allele frequency- G:0.40NS EA NA WA CSA 2344
    rs1144768601,2
    F--109113216(+) CAAAAC/TGTAAA 1 -- us2k11Minor allele frequency- T:0.02WA 118
    rs775214941,2
    C,F--109113221(+) CGTAAA/CTTATT 1 -- us2k10--------
    rs1493954821,2
    --109113310(+) ACACAA/GGGAAC 1 -- us2k10--------
    rs46239511,2
    C,F,A,H--109113326(+) AAGGGT/CCATAT 1 -- us2k127Minor allele frequency- C:0.26NS EA NA WA CSA 2545
    rs1851346681,2
    --109113336(+) TGTTAC/TATAAG 1 -- us2k10--------
    rs769452681,2
    C,F--109113429(+) TGAAGA/GAAAAA 1 -- us2k13Minor allele frequency- G:0.16WA 122

    HapMap Linkage Disequilibrium report for DAO (109252708 - 109294819 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DAO:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2197774CNV Deletion18987734
    esv2422361CNV Duplication17116639
    nsv455711CNV Loss19166990
    nsv524524CNV Gain19592680

    Human Gene Mutation Database (HGMD): DAO
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DAO
    DNA2.0 Custom Variant and Variant Library Synthesis for DAO

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 124050   
    OMIM disorders: 181500  
    14 diseases for DAO:    
    About MalaCards
    bipolar i disorder    primary hyperoxaluria    schizophrenia    amyotrophic lateral sclerosis
    bipolar disorder    zellweger syndrome    nephrotic syndrome    autism spectrum disorder
    lateral sclerosis    crohn's disease    tuberculosis    retinitis
    endotheliitis    neuronitis

    1 disease from the University of Copenhagen DISEASES database for DAO:
    Schizophrenia

    DAO for disorders           About GeneDecksing

    9 Novoseek inferred disease relationships for DAO gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    hypofunction 74.6 2 12625025 (1), 18378121 (1)
    schizophrenia 74 164 17492767 (7), 18378121 (7), 16842973 (6), 19786963 (5) (see all 42)
    bipolar disorder 52.7 11 18165970 (3), 14966479 (2), 18378121 (2), 19586533 (1) (see all 6)
    zellweger syndrome 44.2 1 11330064 (1)
    tumors 5.51 2 19694805 (1), 14735461 (1)
    nephrotic syndrome 2.15 3 9582550 (2)
    psychiatric disorder 2.07 2 16183301 (1)
    renal disease 0 2 8496288 (1), 9582550 (1)
    cancer 0 4 19694805 (2), 15651667 (1), 12564842 (1)

    Genetic Association Database (GAD): DAO
    Human Genome Epidemiology (HuGE) Navigator: DAO (57 documents)

    Export disorders for DAO gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAO gene, integrated from 10 sources (see all 197):
    (articles sorted by number of sources associating them with DAO)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning and chromosomal localization of a human gene encoding D-amino-acid oxidase. (PubMed id 1356107)1, 2, 3, 9 Fukui K. and Miyake Y. (J. Biol. Chem. 1992)
    2. D-amino acid oxidase (DAO) genotype and mood symptomatology in schizophrenia. (PubMed id 17890006)1, 4, 9 Corvin A....Gill M. (Neurosci. Lett. 2007)
    3. Crystal structure of human D-amino acid oxidase: context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring. (PubMed id 17088322)1, 2, 9 Kawazoe T.... Fukui K. (Protein Sci. 2006)
    4. Evidence for association and epistasis at the DAOA/G30 and D-amino acid oxidase loci in an Irish schizophrenia sample. (PubMed id 17492767)1, 4, 9 Corvin A....Gill M. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)
    5. Structural basis of D-DOPA oxidation by D-amino acid oxidase: alternative pathway for dopamine biosynthesis. (PubMed id 17303072)1, 2, 9 Kawazoe T.... Fukui K. (Biochem. Biophys. Res. Commun. 2007)
    6. Association analyses of the DAOA/G30 and D-amino-acid oxidase genes in schizophrenia: further evidence for a role in schizophrenia. (PubMed id 17627036)1, 4, 9 Shinkai T....Kennedy J.L. (Neuromolecular Med. 2007)
    7. Association of DAAO with schizophrenia in the Chinese population. (PubMed id 15464270)1, 4, 9 Liu X....He L. (Neurosci. Lett. 2004)
    8. DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. (PubMed id 19439994)1, 4, 9 JAPnsson E.G....Terenius L. (Neuropsychobiology 2009)
    9. Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia. (PubMed id 19586533)1, 4, 9 Bass N.J....Gurling H.M. (Behav Brain Funct 2009)
    10. Association of DAO and G72(DAOA)/G30 genes with bipolar affective disorder. (PubMed id 18165970)1, 4, 9 Prata D....Collier D. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1610 HGNC: 2671 AceView: DAO Ensembl:ENSG00000110887 euGenes: HUgn1610
    ECgene: DAO Kegg: 1610 H-InvDB: DAO

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DAO Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DAO gene:
    Search GeneIP for patents involving DAO

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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