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Aliases for DAO Gene

Aliases for DAO Gene

  • D-Amino-Acid Oxidase 2 3
  • DAMOX 3 4 6
  • EC 1.4.3.3 4 63
  • DAAO 3 4
  • D-Amino Acid Oxidase 3
  • EC 1.4.3 63
  • OXDA 3

External Ids for DAO Gene

Previous GeneCards Identifiers for DAO Gene

  • GC12U990015
  • GC12P109154
  • GC12P107776
  • GC12P109273
  • GC12P106338

Summaries for DAO Gene

Entrez Gene Summary for DAO Gene

  • This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]

GeneCards Summary for DAO Gene

DAO (D-Amino-Acid Oxidase) is a Protein Coding gene. Diseases associated with DAO include schizophrenia and primary hyperoxaluria. Among its related pathways are Metabolism and Arginine and proline metabolism. GO annotations related to this gene include receptor binding and cofactor binding. An important paralog of this gene is DDO.

UniProtKB/Swiss-Prot for DAO Gene

  • Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAO Gene

Genomics for DAO Gene

Regulatory Elements for DAO Gene

Genomic Location for DAO Gene

Start:
108,858,932 bp from pter
End:
108,901,043 bp from pter
Size:
42,112 bases
Orientation:
Plus strand

Genomic View for DAO Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAO Gene

Proteins for DAO Gene

  • Protein details for DAO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14920-OXDA_HUMAN
    Recommended name:
    D-amino-acid oxidase
    Protein Accession:
    P14920
    Secondary Accessions:
    • B2R7I5
    • Q16758
    • Q8N6R2

    Protein attributes for DAO Gene

    Size:
    347 amino acids
    Molecular mass:
    39474 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DAO Gene

neXtProt entry for DAO Gene

Proteomics data for DAO Gene at MOPED

Post-translational modifications for DAO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAO Gene

Domains for DAO Gene

Protein Domains for DAO Gene

Suggested Antigen Peptide Sequences for DAO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14920

UniProtKB/Swiss-Prot:

OXDA_HUMAN :
  • P14920
Family:
  • Belongs to the DAMOX/DASOX family.
genes like me logo Genes that share domains with DAO: view

No data available for Gene Families for DAO Gene

Function for DAO Gene

Molecular function for DAO Gene

GENATLAS Biochemistry: D-amino-oxidase,glycine oxidase catalyzing the synthesis of glyoxylate,peroxisomal
UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=3.6 mM for D-serine {ECO:0000269 PubMed:17088322, ECO:0000269 PubMed:17303072}; KM=1.7 mM for D-proline {ECO:0000269 PubMed:17088322, ECO:0000269 PubMed:17303072}; KM=1.1 mM for D-tyrosine {ECO:0000269 PubMed:17088322, ECO:0000269 PubMed:17303072}; KM=1.5 mM for D-DOPA {ECO:0000269 PubMed:17088322, ECO:0000269 PubMed:17303072}; KM=1.2 mM for D-phenylalanine {ECO:0000269 PubMed:17088322, ECO:0000269 PubMed:17303072}; KM=0.9 mM for D-alanine {ECO:0000269 PubMed:17088322, ECO:0000269 PubMed:17303072};
UniProtKB/Swiss-Prot CatalyticActivity: A D-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2).
UniProtKB/Swiss-Prot Function: Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

Enzyme Numbers (IUBMB) for DAO Gene

Gene Ontology (GO) - Molecular Function for DAO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003884 D-amino-acid oxidase activity TAS --
GO:0005102 receptor binding IPI 20178365
GO:0005515 protein binding IPI 12364586
GO:0016491 oxidoreductase activity --
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor --
genes like me logo Genes that share ontologies with DAO: view
genes like me logo Genes that share phenotypes with DAO: view

Animal Model Products

CRISPR Products

No data available for Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for DAO Gene

Localization for DAO Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAO Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAO Gene COMPARTMENTS Subcellular localization image for DAO gene
Compartment Confidence
cytosol 5
peroxisome 5
extracellular 2
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DAO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 colocalizes_with mitochondrial outer membrane IDA 21679769
GO:0005777 peroxisome IDA 18544534
GO:0005778 peroxisomal membrane IDA 21679769
GO:0005782 peroxisomal matrix TAS --
GO:0005829 cytosol IDA 21679769
genes like me logo Genes that share ontologies with DAO: view

Pathways for DAO Gene

genes like me logo Genes that share pathways with DAO: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DAO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006551 leucine metabolic process IEA --
GO:0006562 proline catabolic process IDA 16616139
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0036088 D-serine catabolic process IDA 18544534
GO:0042416 dopamine biosynthetic process IDA 17303072
genes like me logo Genes that share ontologies with DAO: view

Compounds for DAO Gene

(16) HMDB Compounds for DAO Gene

Compound Synonyms Cas Number PubMed IDs
1-Pyrroline-2-carboxylic acid
  • 3,4-dihydro-2H-pyrrole-5-carboxylic acid
2139-03-9
1-Pyrroline-4-hydroxy-2-carboxylate
  • 4-hydroxy-1-pyrroline-2-carboxylate
9054-77-7
4-Hydroxy-L-proline
  • L-4-hydroxy-proline
30724-02-8
5-Amino-2-oxopentanoic acid
  • 2-Oxo-5-amino-pentanoate
Not Available
Ammonia
  • NH3
7664-41-7

(8) Drugbank Compounds for DAO Gene

(43) Novoseek inferred chemical compound relationships for DAO Gene

Compound -log(P) Hits PubMed IDs
glutaryl-7-aminocephalosporanic acid 76.9 4
7-aminocephalosporanic acid 76.7 7
flavin 74.3 24
cephalosporin c 70.2 4
pipecolic acid 69 4
genes like me logo Genes that share compounds with DAO: view

Transcripts for DAO Gene

Unigene Clusters for DAO Gene

D-amino-acid oxidase:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAO

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAO Gene

No ASD Table

Relevant External Links for DAO Gene

GeneLoc Exon Structure for
DAO
ECgene alternative splicing isoforms for
DAO

Expression for DAO Gene

mRNA expression in normal human tissues for DAO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAO Gene

This gene is overexpressed in Liver (15.7), Brain - Cerebellum (10.8), Brain - Spinal cord (cervical c-1) (8.9), Brain - Cerebellar Hemisphere (6.6), and Kidney - Cortex (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DAO Gene

SOURCE GeneReport for Unigene cluster for DAO Gene Hs.113227

genes like me logo Genes that share expressions with DAO: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DAO Gene

Orthologs for DAO Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DAO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAO 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DAO 35
  • 87.8 (n)
  • 83.29 (a)
DAO 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAO 35
  • 87.13 (n)
  • 83.29 (a)
DAO 36
  • 76 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dao 35
  • 82.13 (n)
  • 80.87 (a)
Dao 16
Dao 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DAO 36
  • 54 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAO 36
  • 70 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dao 35
  • 82.47 (n)
  • 80.64 (a)
lizard
(Anolis carolinensis)
Reptilia DAO 36
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dao 35
  • 64.36 (n)
  • 62.25 (a)
Str.12003 35
zebrafish
(Danio rerio)
Actinopterygii dao.1 36
  • 59 (a)
OneToMany
dao.2 36
  • 59 (a)
OneToMany
dao.3 35
  • 64 (n)
  • 62.02 (a)
dao.3 36
  • 59 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001116 35
  • 47.44 (n)
  • 37.3 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11236 35
  • 44.98 (n)
  • 33.33 (a)
CG12338 36
  • 35 (a)
OneToMany
CG11236 37
  • 31 (a)
worm
(Caenorhabditis elegans)
Secernentea daao-1 36
  • 36 (a)
ManyToMany
Y69A2AR.5 37
  • 34 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08492g 35
  • 38.46 (n)
  • 28 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 23 (a)
OneToOne
Species with no ortholog for DAO:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAO Gene

ENSEMBL:
Gene Tree for DAO (if available)
TreeFam:
Gene Tree for DAO (if available)

Paralogs for DAO Gene

Paralogs for DAO Gene

Selected SIMAP similar genes for DAO Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DAO: view

Variants for DAO Gene

Sequence variations from dbSNP and Humsavar for DAO Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs762451 -- 108,880,258(+) GGACA(A/G)GGGTT intron-variant, upstream-variant-2KB
rs1053875 -- 108,900,815(+) AGAAA(A/G)TCAAA utr-variant-3-prime
rs1808351 -- 108,882,438(+) aaccc(A/G)ggagg intron-variant
rs2070585 -- 108,880,270(+) GGAGA(A/G)GGGAG intron-variant, upstream-variant-2KB
rs2070586 -- 108,883,944(+) TCTGC(A/G)GGAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAO Gene

Variant ID Type Subtype PubMed ID
esv2422361 CNV Duplication 17116639
nsv524524 CNV Gain 19592680
esv2197774 CNV Deletion 18987734
nsv455711 CNV Loss 19166990

Relevant External Links for DAO Gene

HapMap Linkage Disequilibrium report
DAO
Human Gene Mutation Database (HGMD)
DAO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAO Gene

Disorders for DAO Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for DAO Gene including...

Search for DAO Gene in MalaCards »

(1) OMIM Diseases for DAO Gene (124050)

(1) University of Copenhagen DISEASES for DAO Gene

(9) Novoseek inferred disease relationships for DAO Gene

Disease -log(P) Hits PubMed IDs
hypofunction 74.6 2
schizophrenia 74 103
bipolar disorder 52.7 10
zellweger syndrome 44.2 1
tumors 5.51 2

Relevant External Links for DAO

Genetic Association Database (GAD)
DAO
Human Genome Epidemiology (HuGE) Navigator
DAO
genes like me logo Genes that share disorders with DAO: view

No data available for UniProtKB/Swiss-Prot for DAO Gene

Publications for DAO Gene

  1. Molecular cloning and chromosomal localization of a human gene encoding D-amino-acid oxidase. (PMID: 1356107) Fukui K. … Miyake Y. (J. Biol. Chem. 1992) 2 3 4 23
  2. Association of DAAO with schizophrenia in the Chinese population. (PMID: 15464270) Liu X. … He L. (Neurosci. Lett. 2004) 3 23 48
  3. Bipolar I disorder and schizophrenia: a 440-single-nucleotide polymorphism screen of 64 candidate genes among Ashkenazi Jewish case-parent trios. (PMID: 16380905) Fallin M.D. … Pulver A.E. (Am. J. Hum. Genet. 2005) 3 23 48
  4. Crystal structure of human D-amino acid oxidase: context-dependent variability of the backbone conformation of the VAAGL hydrophobic stretch located at the si-face of the flavin ring. (PMID: 17088322) Kawazoe T. … Fukui K. (Protein Sci. 2006) 3 4 23
  5. Association of schizophrenia with DTNBP1 but not with DAO, DAOA, NRG1 and RGS4 nor their genetic interaction. (PMID: 17408693) Vilella E. … Torres M. (J Psychiatr Res 2008) 3 23 48

Products for DAO Gene

Sources for DAO Gene

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