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Aliases for DAO Gene

Aliases for DAO Gene

  • D-Amino Acid Oxidase 2 3 5
  • EC 1.4.3.3 4 61
  • DAMOX 3 4
  • DAAO 3 4
  • D-Amino-Acid Oxidase 3
  • EC 1.4.3 61
  • OXDA 3

External Ids for DAO Gene

Previous GeneCards Identifiers for DAO Gene

  • GC12U990015
  • GC12P109154
  • GC12P107776
  • GC12P109273
  • GC12P106338

Summaries for DAO Gene

Entrez Gene Summary for DAO Gene

  • This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]

GeneCards Summary for DAO Gene

DAO (D-Amino Acid Oxidase) is a Protein Coding gene. Diseases associated with DAO include Amyotrophic Lateral Sclerosis 1 and Schizophrenia. Among its related pathways are Glyoxylate metabolism and glycine degradation and Peroxisome. GO annotations related to this gene include receptor binding and protein dimerization activity. An important paralog of this gene is DDO.

UniProtKB/Swiss-Prot for DAO Gene

  • Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAO Gene

Genomics for DAO Gene

Regulatory Elements for DAO Gene

Enhancers for DAO Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12G108906 1.3 FANTOM5 Ensembl ENCODE 4 +48.9 48940 2.6 CTCF KLF1 PKNOX1 ZSCAN26 TEAD4 ZMYM3 NFXL1 TEAD3 ZFHX2 GATA3 ALKBH2 SART3 USP30 DAO SVOP GC12M108908 PIR41002 GC12M108869
GH12G108117 1 ENCODE 4.6 -741.4 -741378 0.5 HDGF PKNOX1 ATF1 ARNT ZNF766 FOS KLF13 CAVIN1 GTF2B JUNB PWP1 DAO WSCD2 GC12P108090
GH12G109109 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.4 +254.7 254678 8.5 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT AGO1 ARID4B SIN3A DMAP1 ACACB MYO1H ALKBH2 UNG DAO ENSG00000256139 LOC105369974
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DAO on UCSC Golden Path with GeneCards custom track

Promoters for DAO Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000057118 -1632 2201 HDGF ARNT WRNIP1 ARID4B SIN3A FEZF1 ZBTB7B ZNF766 ZNF143 FOS

Genomic Location for DAO Gene

Chromosome:
12
Start:
108,858,932 bp from pter
End:
108,901,043 bp from pter
Size:
42,112 bases
Orientation:
Plus strand

Genomic View for DAO Gene

Genes around DAO on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAO Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAO Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAO Gene

Proteins for DAO Gene

  • Protein details for DAO Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P14920-OXDA_HUMAN
    Recommended name:
    D-amino-acid oxidase
    Protein Accession:
    P14920
    Secondary Accessions:
    • B2R7I5
    • Q16758
    • Q8N6R2

    Protein attributes for DAO Gene

    Size:
    347 amino acids
    Molecular mass:
    39474 Da
    Cofactor:
    Name=FAD; Xref=ChEBI:CHEBI:57692;
    Quaternary structure:
    • Homodimer.

    Three dimensional structures from OCA and Proteopedia for DAO Gene

neXtProt entry for DAO Gene

Selected DME Specific Peptides for DAO Gene

P14920:
  • ERYHSVLQ
  • NCTGVWA
  • VIGAGVIGLSTALCIHERYH
  • GVIGLSTA
  • TGFRPVR
  • VTLGGIFQ
  • LEPTLKNA
  • WLTERLTERGVK
  • EVIHNYGHGGYGLTIHWGCA
  • YADRFTP

Post-translational modifications for DAO Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Domains & Families for DAO Gene

Protein Domains for DAO Gene

Suggested Antigen Peptide Sequences for DAO Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P14920

UniProtKB/Swiss-Prot:

OXDA_HUMAN :
  • Belongs to the DAMOX/DASOX family.
Family:
  • Belongs to the DAMOX/DASOX family.
genes like me logo Genes that share domains with DAO: view

No data available for Gene Families for DAO Gene

Function for DAO Gene

Molecular function for DAO Gene

GENATLAS Biochemistry:
D-amino-oxidase,glycine oxidase catalyzing the synthesis of glyoxylate,peroxisomal
UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=3.6 mM for D-serine {ECO:0000269 PubMed:17088322, ECO:0000269 PubMed:17303072}; KM=1.7 mM for D-proline {ECO:0000269 PubMed:17088322, ECO:0000269 PubMed:17303072}; KM=1.1 mM for D-tyrosine {ECO:0000269 PubMed:17088322, ECO:0000269 PubMed:17303072}; KM=1.5 mM for D-DOPA {ECO:0000269 PubMed:17088322, ECO:0000269 PubMed:17303072}; KM=1.2 mM for D-phenylalanine {ECO:0000269 PubMed:17088322, ECO:0000269 PubMed:17303072}; KM=0.9 mM for D-alanine {ECO:0000269 PubMed:17088322, ECO:0000269 PubMed:17303072};
UniProtKB/Swiss-Prot CatalyticActivity:
A D-amino acid + H(2)O + O(2) = a 2-oxo acid + NH(3) + H(2)O(2).
UniProtKB/Swiss-Prot Function:
Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D-amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

Enzyme Numbers (IUBMB) for DAO Gene

Gene Ontology (GO) - Molecular Function for DAO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003884 D-amino-acid oxidase activity TAS --
GO:0005102 receptor binding IPI 20178365
GO:0005515 protein binding IPI 12364586
GO:0016491 oxidoreductase activity IEA --
GO:0046983 protein dimerization activity IDA 16616139
genes like me logo Genes that share ontologies with DAO: view
genes like me logo Genes that share phenotypes with DAO: view

Human Phenotype Ontology for DAO Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DAO Gene

MGI Knock Outs for DAO:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for DAO Gene

Localization for DAO Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAO Gene

Peroxisome.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAO gene
Compartment Confidence
peroxisome 5
cytosol 5
extracellular 2
nucleus 2
mitochondrion 1
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for DAO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005741 colocalizes_with mitochondrial outer membrane IDA 21679769
GO:0005777 peroxisome IDA,IEA 18544534
GO:0005778 peroxisomal membrane IDA 21679769
GO:0005782 peroxisomal matrix TAS --
GO:0005829 cytosol IDA 21679769
genes like me logo Genes that share ontologies with DAO: view

Pathways & Interactions for DAO Gene

genes like me logo Genes that share pathways with DAO: view

Gene Ontology (GO) - Biological Process for DAO Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006562 proline catabolic process IDA 16616139
GO:0034641 cellular nitrogen compound metabolic process TAS --
GO:0036088 D-serine catabolic process IDA 18544534
GO:0042416 dopamine biosynthetic process IDA 17303072
GO:0046416 D-amino acid metabolic process IEA --
genes like me logo Genes that share ontologies with DAO: view

No data available for SIGNOR curated interactions for DAO Gene

Drugs & Compounds for DAO Gene

(36) Drugs for DAO Gene - From: DrugBank, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
FAD Approved Pharma Target 0
Oxygen Approved, Vet_approved Pharma 0
Benzoic Acid Approved Pharma Target 8
Water Approved Pharma 0
Glycine Approved, Vet_approved Nutra Full agonist, Agonist 232

(30) Additional Compounds for DAO Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(7R)-7-(5-Carboxy-5-oxopentanoyl)aminocephalosporinate
1-Pyrroline-2-carboxylic acid
  • 1-Pyrroline-2-carboxylate
  • 3,4-Dihydro-2H-pyrrole-5-carboxylate
  • 3,4-Dihydro-2H-pyrrole-5-carboxylic acid
  • D1-Pyrroline 2-carboxylate
  • D1-Pyrroline 2-carboxylic acid
2139-03-9
1-Pyrroline-4-hydroxy-2-carboxylate
  • 4-Hydroxy-1-pyrroline-2-carboxylate
  • 4-Hydroxy-1-pyrroline-2-carboxylic acid
9054-77-7
4-Hydroxy-L-proline
  • (2S)-4-hydroxypyrrolidine-2-carboxylic acid
  • (4S)-4-hydroxy-L-Proline
  • 4-Hydroxy-L-Proline
  • Allo-4-Hydroxy-L-proline
  • Allo-4-Hydroxyproline
30724-02-8
5-Amino-2-oxopentanoic acid
  • 2-Oxo-5-amino-pentanoate
  • 2-Oxo-5-amino-pentanoic acid
  • 2-Oxo-5-aminopentanoate
  • 2-Oxo-5-aminopentanoic acid
  • 2-Oxo-5-aminovalerate
genes like me logo Genes that share compounds with DAO: view

Transcripts for DAO Gene

Unigene Clusters for DAO Gene

D-amino-acid oxidase:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAO Gene

No ASD Table

Relevant External Links for DAO Gene

GeneLoc Exon Structure for
DAO
ECgene alternative splicing isoforms for
DAO

Expression for DAO Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DAO Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAO Gene

This gene is overexpressed in Liver (x15.7), Brain - Cerebellum (x10.8), Brain - Spinal cord (cervical c-1) (x8.9), Brain - Cerebellar Hemisphere (x6.6), and Kidney - Cortex (x6.5).

Protein differential expression in normal tissues from HIPED for DAO Gene

This gene is overexpressed in Spinal cord (19.0), Liver (17.0), Gallbladder (15.8), and Kidney (11.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DAO Gene



Protein tissue co-expression partners for DAO Gene

NURSA nuclear receptor signaling pathways regulating expression of DAO Gene:

DAO

SOURCE GeneReport for Unigene cluster for DAO Gene:

Hs.113227

Evidence on tissue expression from TISSUES for DAO Gene

  • Kidney(4.7)
  • Liver(4.6)
  • Nervous system(4.6)
  • Intestine(4)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DAO Gene

Germ Layers:
  • ectoderm
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
  • nervous
  • respiratory
  • skeletal muscle
  • skeleton
Organs:
Head and neck:
  • brain
  • cerebellum
  • cranial nerve
  • ear
  • epiglottis
  • face
  • head
  • jaw
  • larynx
  • mandible
  • maxilla
  • mouth
  • neck
  • nose
  • pharynx
  • skull
  • tongue
  • vocal cord
Thorax:
  • bronchus
  • clavicle
  • esophagus
  • heart
  • lung
  • scapula
  • trachea
Abdomen:
  • biliary tract
  • liver
  • stomach
Limb:
  • arm
  • digit
  • finger
  • foot
  • forearm
  • hand
  • humerus
  • lower limb
  • shin
  • shoulder
  • thigh
  • toe
  • upper limb
General:
  • blood vessel
  • peripheral nerve
  • peripheral nervous system
  • spinal cord
genes like me logo Genes that share expression patterns with DAO: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for DAO Gene

Orthologs for DAO Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for DAO Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAO 35
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DAO 34 35
  • 87.8 (n)
dog
(Canis familiaris)
Mammalia DAO 34 35
  • 87.13 (n)
rat
(Rattus norvegicus)
Mammalia Dao 34
  • 82.47 (n)
mouse
(Mus musculus)
Mammalia Dao 34 16 35
  • 82.13 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DAO 35
  • 70 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DAO 35
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DAO 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dao 34
  • 64.36 (n)
Str.12003 34
zebrafish
(Danio rerio)
Actinopterygii dao.3 34 35
  • 64 (n)
dao.1 35
  • 59 (a)
OneToMany
dao.2 35
  • 59 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001116 34
  • 47.44 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG11236 36 34
  • 44.98 (n)
CG12338 35
  • 35 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea daao-1 35
  • 36 (a)
ManyToMany
Y69A2AR.5 36
  • 34 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0A08492g 34
  • 38.46 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 23 (a)
OneToOne
Species where no ortholog for DAO was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAO Gene

ENSEMBL:
Gene Tree for DAO (if available)
TreeFam:
Gene Tree for DAO (if available)

Paralogs for DAO Gene

Paralogs for DAO Gene

(3) SIMAP similar genes for DAO Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with DAO: view

Variants for DAO Gene

Sequence variations from dbSNP and Humsavar for DAO Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1000026799 -- 108,895,570(+) TGTGT(A/G/T)CGCAT intron-variant
rs1000215365 -- 108,879,094(+) CTCCA(C/T)CCACC upstream-variant-2KB
rs1000295499 -- 108,882,623(+) CTGCA(A/T)CCTGG intron-variant
rs1000539784 -- 108,901,178(+) CAGCT(A/T)TTCAC downstream-variant-500B
rs1000648028 -- 108,879,994(+) GCGAG(G/T)TCTCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DAO Gene

Variant ID Type Subtype PubMed ID
esv2197774 CNV deletion 18987734
esv2422361 CNV duplication 17116639
nsv455711 CNV loss 19166990
nsv480209 CNV novel sequence insertion 20440878
nsv524524 CNV gain 19592680
nsv560115 CNV loss 21841781

Variation tolerance for DAO Gene

Residual Variation Intolerance Score: 72.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.80% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAO Gene

Human Gene Mutation Database (HGMD)
DAO
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAO

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAO Gene

Disorders for DAO Gene

MalaCards: The human disease database

(11) MalaCards diseases for DAO Gene - From: OMIM, Orphanet, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
amyotrophic lateral sclerosis 1
  • amyotrophic lateral sclerosis
schizophrenia
  • schizophrenia 12
amyotrophic lateral sclerosis 11
  • amyotrophic lateral sclerosis type 11
amyotrophic lateral sclerosis 7
  • amyotrophic lateral sclerosis type 7
amyotrophic lateral sclerosis 6, with or without frontotemporal dementia
  • amyotrophic lateral sclerosis type 6
- elite association - COSMIC cancer census association via MalaCards
Search DAO in MalaCards View complete list of genes associated with diseases

Relevant External Links for DAO

Genetic Association Database (GAD)
DAO
Human Genome Epidemiology (HuGE) Navigator
DAO
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAO
genes like me logo Genes that share disorders with DAO: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAO Gene

Publications for DAO Gene

  1. Molecular cloning and chromosomal localization of a human gene encoding D-amino-acid oxidase. (PMID: 1356107) Fukui K. … Miyake Y. (J. Biol. Chem. 1992) 2 3 4 22 64
  2. DTNBP1, NRG1, DAOA, DAO and GRM3 polymorphisms and schizophrenia: an association study. (PMID: 19439994) JAPnsson E.G. … Terenius L. (Neuropsychobiology 2009) 3 22 46 64
  3. Evidence for the association of the DAOA (G72) gene with schizophrenia and bipolar disorder but not for the association of the DAO gene with schizophrenia. (PMID: 19586533) Bass N.J. … Gurling H.M. (Behav Brain Funct 2009) 3 22 46 64
  4. Association analysis of glycine- and serine-related genes in a Japanese population of patients with schizophrenia. (PMID: 19223009) Ohnuma T. … Arai H. (Prog. Neuropsychopharmacol. Biol. Psychiatry 2009) 3 22 46 64
  5. Dysbindin and d-amino-acid-oxidase gene polymorphisms associated with positive and negative symptoms in schizophrenia. (PMID: 19729970) Wirgenes K.V. … Andreassen O.A. (Neuropsychobiology 2009) 3 22 46 64

Products for DAO Gene

Sources for DAO Gene

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