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DAND5 Gene

protein-coding   GIFtS: 47
GCID: GC19P013081

DAN Domain Family Member 5, BMP Antagonist

(Previous names: DAN domain family, member 5)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
DAN Domain Family Member 5, BMP Antagonist1 2     DANTE2 5
CER22 3 5     CRL22
DAN Domain Family, Member 51 2     Cerberus 22
Cerberus-Like Protein 22 3     Cerberus-Like 22
Cysteine Knot Superfamily 1, BMP Antagonist 32 3     cerl-22
CKTSF1B32 3     DAN Domain Family Member 52
GREM32 3     gremlin-32
SP12 3     Cerl-23
CERL22 5     Gremlin-33
COCO2 5     

External Ids:    HGNC: 267801   Entrez Gene: 1996992   Ensembl: ENSG000001792847   OMIM: 6090685   UniProtKB: Q8N9073   

Export aliases for DAND5 gene to outside databases

Previous GC identifers: GC19P012945 GC19P012652


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAND5 Gene:
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists
contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP
antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered
ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to
BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning,
and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal
signaling pathway which patterns left/right body asymmetry. (provided by RefSeq, Jul 2008)

GeneCards Summary for DAND5 Gene:
DAND5 (DAN domain family member 5, BMP antagonist) is a protein-coding gene. Diseases associated with DAND5 include malignant syringoma, and syringoma. GO annotations related to this gene include morphogen activity. An important paralog of this gene is CER1.

UniProtKB/Swiss-Prot: DAND5_HUMAN, Q8N907
Function: Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4
signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth
and differentiation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAND5 gene promoter:
         GATA-3   ATF-2   Lmo2   STAT5A   Ik-3   Tal-1beta   c-Jun   NF-kappaB1   ITF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAND5 promoter sequence
   Search Chromatin IP Primers for DAND5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAND5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13

DAND5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAND5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013081:  view genomic region     (about GC identifiers)

Start:
13,075,973 bp from pter      End:
13,085,567 bp from pter
Size:
9,595 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DAND5_HUMAN, Q8N907 (See protein sequence)
Recommended Name: DAN domain family member 5 precursor  
Size: 189 amino acids; 20180 Da

Explore the universe of human proteins at neXtProt for DAND5: NX_Q8N907

Explore proteomics data for DAND5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn38

  • See DAND5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_689867.1  
    ENSEMBL proteins: 
     ENSP00000467806   ENSP00000323155  

    DAND5 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for DAND5 (COCO)
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    OriGene Protein Over-expression Lysate for DAND5
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    Novus Biologicals DAND5 Protein
    Novus Biologicals DAND5 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DAND5

    DAND5 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DAND5 (COCO)
    OriGene Antibodies for DAND5
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    Novus Biologicals DAND5 Antibodies
    Abcam antibodies for DAND5
    Cloud-Clone Corp. Antibodies for DAND5
    Search ThermoFisher Antibodies for DAND5
    LSBio Antibodies in human, mouse, rat for DAND5

    DAND5 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DAND5
    R&D Systems ELISAs for DAND5 (COCO)
    GenScript Custom Assay Services for DAND5
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DAND5
    Cloud-Clone Corp. CLIAs for DAND5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR016860 Cerberus
     IPR004133 DAN

    Graphical View of Domain Structure for InterPro Entry Q8N907

    ProtoNet protein and cluster: Q8N907

    UniProtKB/Swiss-Prot: DAND5_HUMAN, Q8N907
    Similarity: Belongs to the DAN family
    Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain


    DAND5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAND5_HUMAN, Q8N907
    Function: Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4
    signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth
    and differentiation (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0016015morphogen activity ISS--
         
    DAND5 for ontologies           About GeneDecksing


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dand5):
     cardiovascular system  embryogenesis  growth/size/body  mortality/aging  respiratory system 

    DAND5 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DAND5
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DAND5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DAND5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAND5

    Transcription Factor Targeting: 
    Selected GeneGlobe predicted Target genes for DAND5 (see all 996):
    ABCA1,  ABCA7,  ABCB9,  ABCC10,  ABCC3,  ABCC4,  ABCC6,  ABCC6P1,  ABCC6P2,  ABCC8

    miRNA
    Products:
        
    miRTarBase miRNAs that target DAND5:
    hsa-mir-186-5p (MIRT045067), hsa-mir-1 (MIRT035536), hsa-let-7a-5p (MIRT052453), hsa-mir-16-5p (MIRT031577), hsa-let-7b-5p (MIRT052264), hsa-mir-29b-3p (MIRT000445), hsa-mir-22-3p (MIRT007329), hsa-mir-124-3p (MIRT002660), hsa-mir-335-5p (MIRT017513), hsa-let-7f-5p (MIRT051372), hsa-mir-218-5p (MIRT004246), hsa-mir-149-5p (MIRT007014), hsa-mir-99b-5p (MIRT044192), hsa-mir-21-5p (MIRT006236), hsa-mir-133a-3p (MIRT035537), hsa-mir-125a-5p (MIRT045732), hsa-mir-625-5p (MIRT039599), hsa-mir-27a-3p (MIRT002403)

    Block miRNA regulation of human, mouse, rat DAND5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate DAND5:
    hsa-miR-122 hsa-miR-218-2* hsa-miR-584 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidDAND5 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DAND5
    Predesigned siRNA for gene silencing in human, mouse, rat DAND5

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DAND5

    Clone
    Products:
         
    OriGene clones in human, mouse for DAND5 (see all 5)
    OriGene ORF clones in mouse, rat for DAND5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DAND5 (NM_152654)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAND5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAND5

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DAND5
    Browse ESI BIO Cell Lines and PureStem Progenitors for DAND5 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAND5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DAND5_HUMAN, Q8N907: Secreted (Probable)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular4
    cytoskeleton1
    mitochondrion1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS15466485

    DAND5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DAND5 (see all 11)
        ErbB2-ErbB3 Heterodimers
    HMGB1 Pathway
    JAK-STAT Pathway
    Estrogen Pathway
    Signaling in Gap Junctions


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DAND5
    Interactions:

        Search GeneGlobe Interaction Network for DAND5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for DAND5 (ENSP000003231554) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NODALENSP000002871394STRING: ENSP00000287139
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003140determination of left/right asymmetry in lateral mesoderm ISS--
    GO:0003281ventricular septum development ISS--
    GO:0003283atrial septum development ISS--
    GO:0007368determination of left/right symmetry ----
    GO:0017015regulation of transforming growth factor beta receptor signaling pathway ----

    DAND5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAND5

    1 Novoseek inferred chemical compound relationship for DAND5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cysteine 45.5 5 15254711 (2), 15806314 (1)



    DAND5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DAND5 gene: 
    NM_152654.2  

    Unigene Cluster for DAND5:

    DAN domain family member 5, BMP antagonist
    Hs.331981  [show with all ESTs]
    Unigene Representative Sequence: BC025333
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000585548 ENST00000317060(uc010dyz.1 uc002mwc.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DAND5 using miScript Target Protectors
    4 qRT-PCR Assays for microRNAs that regulate DAND5:
    hsa-miR-122 hsa-miR-218-2* hsa-miR-584 hsa-miR-646
    SwitchGear 3'UTR luciferase reporter plasmidDAND5 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DAND5
    Predesigned siRNA for gene silencing in human, mouse, rat DAND5
    Clone
    Products:
         
    OriGene clones in human, mouse for DAND5 (see all 5)
    OriGene ORF clones in mouse, rat for DAND5
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DAND5 (NM_152654)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAND5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAND5
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DAND5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DAND5
      QuantiTect SYBR Green Assays in human, mouse, rat DAND5
      QuantiFast Probe-based Assays in human, mouse, rat DAND5

    Additional mRNA sequence: 

    AB070695.1 AK095926.1 BC025333.1 BC101800.1 BC113476.1 

    2 DOTS entries:

    DT.100009965  DT.91954794 

    5 AceView cDNA sequences:

    AB070695 BG330085 AK095926 NM_152654 BC025333 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAND5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GCATTCCACA
    DAND5 Expression
    About this image


    DAND5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive Node Cells Primitive Node
     
     Epiblast (Early Embryo)
             Primitive Node Cells Primitive Node
     
     Testis (Reproductive System)
    DAND5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAND5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.331981
        Custom PCR Arrays for DAND5
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DAND5
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DAND5
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    QuantiFast Probe-based Assays in human, mouse, rat DAND5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAND5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DAND5 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dand51 , 5 DAN domain family, member 51, 5 72.34(n)1
    64.29(a)1
      8 (41.17 cM)5
    238631  NM_201227.31  NP_957679.11 
     848154055 
    zebrafish
    (Danio rerio)
    Actinopterygii dand56
    DAN domain family, member 5
    19(a)
    1 → many
    1(52320998-52323243) ENSDARG00000036471


    ENSEMBL Gene Tree for DAND5 (if available)
    TreeFam Gene Tree for DAND5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAND5 gene
    CER12  

    DAND5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAND5 (see all 215)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1387991831,2
    --13078436(+) ACCTGC/TTTTTC 1 -- us2k10--------
    rs97494791,2
    C,F--13078465(+) atagtG/Aagacc 1 -- us2k15Minor allele frequency- A:0.28WA CSA 126
    rs1422517711,2
    --13078548(+) ACTTTG/TGGAGG 1 -- us2k10--------
    rs1928215141,2
    --13078565(+) TGGGCG/TGATCG 1 -- us2k10--------
    rs1852051091,2
    --13078605(+) GCCAAC/TATAGT 1 -- us2k10--------
    rs1483726621,2
    C--13078638(+) GCTGG-/GCA   
       TAGTT
    GCATA
    1 -- us2k10--------
    rs594027641,2
    C,F--13078677(+) TGGGGG/AGCTGA 1 -- us2k12Minor allele frequency- A:0.50NA CSA 4
    rs1133823501,2
    C,F--13078712(+) GAGGCG/AGAGGT 1 -- us2k13Minor allele frequency- A:0.50WA CSA 6
    rs2007736591,2
    C--13078773(-) GTGTTC/TTTTTT 1 -- us2k10--------
    rs1506618021,2
    --13078866(+) AATTAC/TCTCCT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DAND5 (13075973 - 13085567 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DAND5:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv911082CNV Loss21882294
    nsv911085CNV Loss21882294
    nsv911086CNV Loss21882294
    nsv833754CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DAND5
    DNA2.0 Custom Variant and Variant Library Synthesis for DAND5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609068    OMIM disorders: --

    7 diseases for DAND5:    
    About MalaCards
    malignant syringoma    syringoma    norrie disease    astigmatism
    myopia    basal cell carcinoma    breast cancer

    5 diseases from the University of Copenhagen DISEASES database for DAND5:
    Malignant syringoma     Syringoma     Astigmatism     Basal cell carcinoma
    Myopia

    DAND5 for disorders           About GeneDecksing


    Export disorders for DAND5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAND5 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with DAND5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico. (PubMed id 15254711)1, 2, 3, 9 Katoh M. and Katoh M. (Oncol. Rep. 2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. (PubMed id 22901808)1 Gao H....Giancotti F.G. (Cell 2012)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists. (PubMed id 14525956)1 Avsian-Kretchmer O. and Hsueh A.J. (Mol. Endocrinol. 2004)
    6. The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. (PubMed id 15466485)1 Marques S....Belo J.A. (amp 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. (PubMed id )2 
    9. CER1 is a common target of WNT and NODAL signaling pathways in human embryonic stem cells. (PubMed id 16596263)9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2006)
    10. Comparative genomics on Norrie disease gene. (PubMed id 15806314)9 Katoh M. and Katoh M. (Int. J. Mol. Med. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 199699 HGNC: 26780 AceView: FLJ38607 Ensembl:ENSG00000179284 euGenes: HUgn199699
    ECgene: DAND5 H-InvDB: DAND5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DAND5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DAND5 gene:
    Search GeneIP for patents involving DAND5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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