DAND5 Gene
protein-coding GIFtS : 45
GCID: GC19 P013081
DAN domain family member 5, BMP antagonist (Previous names: DAN domain family, member 5 )
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Aliasesfor DAND5 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases DAN Domain Family Member 5, BMP Antagonist 1 2 CERL22 CER21 2 3 COCO2 CKTSF1B31 2 3 CRL22 GREM31 2 3 Cerberus 22 DANTE1 2 Cerberus-Like 22 DAN Domain Family, Member 51 2 Cerl-23 Cerberus-Like Protein 22 3 DAN Domain Family Member 52 Cysteine Knot Superfamily 1, BMP Antagonist 32 3 Gremlin-33 SP12 3 Cerl-23 DTE1 Gremlin-33 FLJ386071
Export aliases for DAND5 gene to outside databases Previous GC identifers: GC19P012945 GC19P012652
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Summariesfor DAND5 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section Entrez Gene summary for DAND5 : This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. (provided by RefSeq, Jul 2008) UniProtKB/Swiss-Prot: DAND5_HUMAN, Q8N907 Function : Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity)
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Genomic Viewsfor DAND5 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000019.9 NC_018930.1 NT_011295.11 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the DAND5 gene promoter: GATA-3 ATF-2 Lmo2 STAT5A Ik-3 Tal-1beta c-Jun NF-kappaB1 ITF-2 Ik-1 Other transcription factors Search SABiosciences Chromatin IP Primers for DAND5 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAND5
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13 DAND5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 19 GeneLoc Exon Structure
GeneLoc location for GC19P013081: view genomic region
(about GC identifiers )
Start:
13,075,973 bp from pter
End:
13,085,567 bp from pter
Size:
9,595 bases
Orientation:
plus strand
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Proteinsfor DAND5 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: DAND5_HUMAN, Q8N907 (See
protein sequence )Recommended Name: DAN domain family member 5 precursor Size : 189 amino acids; 20180 Da
Subcellular location : Secreted (Probable)Explore the universe of human proteins at neXtProt for DAND5: NX_Q8N907 DAND5 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins: NP_689867.1 ENSEMBL proteins: ENSP00000467806 ENSP00000323155 Human Recombinant Protein Products for DAND5: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
DAND5 for ontologies About GeneDecksing DAND5 Antibody Products: Assay Products for DAND5:
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Protein
Domains / Familiesfor DAND5 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
DAND5 for domains About GeneDecksing 2 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q8N907 ProtoNet protein and cluster: Q8N907
UniProtKB/Swiss-Prot: DAND5_HUMAN, Q8N907 Similarity : Belongs to the DAN familySimilarity : Contains 1 CTCK (C-terminal cystine knot-like) domain
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Functionfor DAND5 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Molecular Function: UniProtKB/Swiss-Prot Summary: DAND5_HUMAN, Q8N907 Function : Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity)
Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005515 protein binding
-- -- GO:0016015 morphogen activity
ISS --
DAND5 for ontologies About GeneDecksing Phenotypes: 5 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Dand5) :
DAND5 for phenotypes About GeneDecksing Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DAND5 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DAND5OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DAND5 (NM_152654 ) Sino Biological Human cDNA Clone for DAND5 DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DAND5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DAND5
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAND5
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Pathways & Interactionsfor DAND5 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DAND5 Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12 ): About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0003127 detection of nodal flow
-- -- GO:0003140 determination of left/right asymmetry in lateral mesoderm
ISS -- GO:0003281 ventricular septum development
ISS -- GO:0003283 atrial septum development
ISS -- GO:0007368 determination of left/right symmetry
-- --
DAND5 for ontologies About GeneDecksing
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Drugs & Compoundsfor DAND5 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section
DAND5 for compounds About GeneDecksing Browse Tocris compounds for DAND5 1 Novoseek chemical compound relationship for DAND5 gene About this table
Compound
-log (P-Val)
Hits
PubMed IDs for Articles with Shared Sentences (# sentences)
cysteine
45.5
5
15254711 (2), 15806314 (1)
Search CenterWatch for drugs/clinical trials and news about DAND5
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Transcriptsfor DAND5 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for DAND5 gene: NM_152654.2 Unigene Cluster for DAND5:
DAN domain family, member 5 Hs.331981 [show with all ESTs ] Unigene Representative Sequence: BC025333 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000585548 ENST00000317060 (uc010dyz.1 uc002mwc.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DAND5 (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DAND5OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector: DAND5 (NM_152654 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for DAND5 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DAND5
Additional cDNA sequence: AB070695.1 AK095926.1 BC025333.1 BC101800.1 BC113476.1
2 DOTS entries : DT.100009965 DT.91954794
5 AceView cDNA sequences :
AB070695 NM_152654 BC025333 AK095926 BG330085 GeneLoc Exon Structure
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Expression for DAND5 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section DAND5 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: GCATTCCACAAbout this image DAND5 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
1 LifeMap In Vivo Development Anatomical Compartment/Cell Tissue Anatomical Compartment
Cell Category (developmental path) Primitive Streak Primitive Node Primitive Node Cells Early Embryo Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
See DAND5 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for DAND5 SOURCE GeneReport for Unigene cluster: Hs.331981 SABiosciences Custom PCR Arrays for DAND5 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DAND5Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat DAND5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DAND5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DAND5 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAND5
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Orthologsfor DAND5 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for DAND5 gene from 2/7 species (see all 7 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
mouse (Mus musculus)
Mammalia
Dand51 , 5
DAN domain family, member 51, 5
72.34(n) 1 64.29(a) 1
 
8 (41.17 cM) 5 23863 1 NM_201227.3 1 NP_957679.1 1 84815405 5
zebrafish (Danio rerio)
Actinopterygii
dand56
DAN domain family, member 5
20(a)
1 → many
1(52320998-52323243)
ENSEMBL Gene Tree for DAND5 (if available)TreeFam Gene Tree for DAND5 (if available)
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Paralogsfor DAND5 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for DAND5 gene CER1 2
DAND5 for paralogs About GeneDecksing
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Genomic Variantsfor DAND5 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 19 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for DAND5 (13075973 - 13085567 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for DAND5: --
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DAND5
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Disorders
/ Diseasesfor DAND5 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
DAND5 for disorders About GeneDecksing
OMIM gene information: 609068
OMIM disorders : --7 diseases for DAND5 : About MalaCards syringoma malignant syringoma norrie disease basal cell carcinoma astigmatism myopia carcinoma 5 diseases from the University of Copenhagen DISEASES database for DAND5 :Malignant syringoma Syringoma Astigmatism Myopia Basal cell carcinoma Export disorders for DAND5 gene to outside databases
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Publicationsfor DAND5 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for DAND5 gene, integrated from 9 sources (see all 12 ): (articles sorted by number of sources associating them with DAND5) Utopia : connect your pdf to the dynamic world of online information
Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico. (PubMed id 15254711) 1 , 2 , 3, 9 Katoh M. and Katoh M. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 1 , 2 Ota T.... Sugano S. (2004) The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. (PubMed id 22901808) 1 Gao H....Giancotti F.G. (2012) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists. (PubMed id 14525956) 1 Avsian-Kretchmer O. and Hsueh A.J. (2004) The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. (PubMed id 15466485) 1 Marques S....Belo J.A. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id ) 2 Aoki H.... Hino O. (2000) CER1 is a common target of WNT and NODAL signaling pathways in human embryonic stem cells. (PubMed id 16596263) 9 Katoh M. and Katoh M. (2006) Comparative genomics on Norrie disease gene. (PubMed id 15806314) 9 Katoh M. and Katoh M. (2005)
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External Searches for DAND5 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DAND5 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing DAND5 gene
(According to HUGE )
About This Section --
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Specialized Databases showing DAND5 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for DAND5 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for DAND5 gene: Search GeneIP for patents involving DAND5 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor DAND5 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
OriGene Antibodies for DAND5 OriGene shRNA RFP for DAND5 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for DAND5 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for DAND5 OriGene Protein Over-expression Lysate for DAND5 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for DAND5 Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for DAND5 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for DAND5 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for DAND5 OriGene Custom Protein Services for DAND5 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DAND5 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing DAND5 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAND5 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat DAND5 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat DAND5 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat DAND5
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DAND5 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAND5
Search ThermoFisher Antibodies for DAND5
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat DAND5
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Aliases for DAND5
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Disorders / Diseases for DAND5
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Expression for DAND5
Function for DAND5
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