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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAND5 Gene

protein-coding   GIFtS: 45
GCID: GC19P013081

DAN domain family member 5, BMP antagonist

(Previous names: DAN domain family, member 5 )
 Explore 7 diseases affiliated with
DAND5 via our new
 Human Malady Compendium 
Biological research products
for DAND5
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
DAN Domain Family Member 5, BMP Antagonist1 2     CERL22
CER21 2 3     COCO2
CKTSF1B31 2 3     CRL22
GREM31 2 3     Cerberus 22
DANTE1 2     Cerberus-Like 22
DAN Domain Family, Member 51 2     Cerl-23
Cerberus-Like Protein 22 3     DAN Domain Family Member 52
Cysteine Knot Superfamily 1, BMP Antagonist 32 3     Gremlin-33
SP12 3     Cerl-23
DTE1     Gremlin-33
FLJ386071     

External Ids:    HGNC: 267801   Entrez Gene: 1996992   Ensembl: ENSG000001792847   OMIM: 6090685   UniProtKB: Q8N9073   

Export aliases for DAND5 gene to outside databases

Previous GC identifers: GC19P012945 GC19P012652


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DAND5:
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain
cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to
which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic
effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an
antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.
In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns
left/right body asymmetry. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: DAND5_HUMAN, Q8N907
Function: Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4
signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and
differentiation (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.1  NT_011295.11  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAND5 gene promoter:
         GATA-3   ATF-2   Lmo2   STAT5A   Ik-3   Tal-1beta   c-Jun   NF-kappaB1   ITF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAND5 promoter sequence
   Search SABiosciences Chromatin IP Primers for DAND5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAND5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.2   Ensembl cytogenetic band:  19p13.2   HGNC cytogenetic band: 19p13

DAND5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAND5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P013081:  view genomic region     (about GC identifiers)

Start:
13,075,973 bp from pter      End:
13,085,567 bp from pter
Size:
9,595 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DAND5_HUMAN, Q8N907 (See protein sequence)
Recommended Name: DAN domain family member 5 precursor  
Size: 189 amino acids; 20180 Da
Subcellular location: Secreted (Probable)

Explore the universe of human proteins at neXtProt for DAND5: NX_Q8N907

DAND5 Protein expression data from MOPED and PaxDb:    About this image 
DAND5 Protein Expression

REFSEQ proteins: NP_689867.1  
ENSEMBL proteins: 
 ENSP00000467806   ENSP00000323155  

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Uscn Proteins for DAND5

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region NAS15466485

DAND5 for ontologies           About GeneDecksing



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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DAND5 for domains           About GeneDecksing

2 InterPro domains/families:
 IPR016860 Cerberus
 IPR004133 DAN

Graphical View of Domain Structure for InterPro Entry Q8N907

ProtoNet protein and cluster: Q8N907

UniProtKB/Swiss-Prot: DAND5_HUMAN, Q8N907
Similarity: Belongs to the DAN family
Similarity: Contains 1 CTCK (C-terminal cystine knot-like) domain


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

     UniProtKB/Swiss-Prot Summary: DAND5_HUMAN, Q8N907
Function: Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4
signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and
differentiation (By similarity)

     Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005515protein binding ----
GO:0016015morphogen activity ISS--
     
DAND5 for ontologies           About GeneDecksing


Phenotypes:
     5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dand5):
 cardiovascular system  embryogenesis  growth/size  mortality/aging  respiratory system 

DAND5 for phenotypes           About GeneDecksing

Animal Models:
   inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DAND5 

miRNA
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miRTarBase miRNAs that target DAND5:
hsa-mir-124 (MIRT002660), hsa-mir-29b (MIRT000445), hsa-mir-218 (MIRT004246)

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SwitchGear 3'UTR luciferase reporter plasmidDAND5 3' UTR sequence
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In Situ Assay
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DAND5

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0003127detection of nodal flow ----
GO:0003140determination of left/right asymmetry in lateral mesoderm ISS--
GO:0003281ventricular septum development ISS--
GO:0003283atrial septum development ISS--
GO:0007368determination of left/right symmetry ----

DAND5 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

DAND5 for compounds           About GeneDecksing

Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DAND5
1 Novoseek chemical compound relationship for DAND5 gene    About this table
Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
cysteine 45.5 5 15254711 (2), 15806314 (1)

Search CenterWatch for drugs/clinical trials and news about DAND5 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DAND5 gene: 
NM_152654.2  

Unigene Cluster for DAND5:

DAN domain family, member 5
Hs.331981  [show with all ESTs]
Unigene Representative Sequence: BC025333
2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000585548 ENST00000317060(uc010dyz.1 uc002mwc.1)

miRNA
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hsa-miR-122 hsa-miR-218-2* hsa-miR-584 hsa-miR-646
SwitchGear 3'UTR luciferase reporter plasmidDAND5 3' UTR sequence
Inhib. RNA
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Clone
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAND5

Additional cDNA sequence: 

AB070695.1 AK095926.1 BC025333.1 BC101800.1 BC113476.1 

2 DOTS entries:

DT.100009965  DT.91954794 

5 AceView cDNA sequences:

AB070695 NM_152654 BC025333 AK095926 BG330085 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DAND5 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCATTCCACA
DAND5 Expression
About this image

DAND5 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell 
Tissue Anatomical Compartment CellCategory (developmental path)
Primitive StreakPrimitive NodePrimitive Node CellsEarly Embryo
Expression: Positive    Negative     Selective marker
Experimental details: Curated     Microarrays     In-situ hybridization

See DAND5 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DAND5

SOURCE GeneReport for Unigene cluster: Hs.331981
    SABiosciences Custom PCR Arrays for DAND5
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAND5

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for DAND5 gene from 2/7 species (see all 7)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dand51 , 5 DAN domain family, member 51, 5 72.34(n)1
64.29(a)1
  8 (41.17 cM)5
238631  NM_201227.31  NP_957679.11 
 848154055 
zebrafish
(Danio rerio)
Actinopterygii dand56
DAN domain family, member 5
20(a)
1 → many
1(52320998-52323243)


ENSEMBL Gene Tree for DAND5 (if available)
TreeFam Gene Tree for DAND5 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for DAND5 gene
CER12  

DAND5 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/161 NCBI SNPs in DAND5 are shown (see all 161    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1387991831,2
--13078436(+) ACCTGC/TTTTTC 1 -- us2k10--------
rs97494791,2
C,F--13078465(+) atagtG/Aagacc 1 -- us2k15Minor allele frequency- A:0.28WA CSA 126
rs1422517711,2
--13078548(+) ACTTTG/TGGAGG 1 -- us2k10--------
rs1928215141,2
--13078565(+) TGGGCG/TGATCG 1 -- us2k10--------
rs1852051091,2
--13078605(+) GCCAAC/TATAGT 1 -- us2k10--------
rs1483726621,2
C--13078638(+) GCTGG-/GCA   
   TAGTT
GCATA
1 -- us2k10--------
rs594027641,2
C,F--13078677(+) TGGGGG/AGCTGA 1 -- us2k12Minor allele frequency- A:0.50NA CSA 4
rs1133823501,2
C,F--13078712(+) GAGGCG/AGAGGT 1 -- us2k13Minor allele frequency- A:0.50WA CSA 6
rs2007736591,2
C--13078773(-) GTGTTC/TTTTTT 1 -- us2k10--------
rs1506618021,2
--13078866(+) AATTAC/TCTCCT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for DAND5 (13075973 - 13085567 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
      Database of Genomic Variants (DGV) variations for DAND5: --

SABiosciences Cancer Mutation PCR Assays
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DAND5 for disorders           About GeneDecksing

OMIM gene information: 609068    OMIM disorders: --

7 diseases for DAND5:    About MalaCards
syringoma    malignant syringoma    norrie disease    basal cell carcinoma
astigmatism    myopia    carcinoma

5 diseases from the University of Copenhagen DISEASES database for DAND5:
Malignant syringoma     Syringoma     Astigmatism     Myopia
Basal cell carcinoma

Export disorders for DAND5 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for DAND5 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with DAND5)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico. (PubMed id 15254711)1, 2, 3, 9 Katoh M. and Katoh M. (2004)
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  3. The BMP inhibitor Coco reactivates breast cancer cells at lung metastatic sites. (PubMed id 22901808)1 Gao H....Giancotti F.G. (2012)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  5. Comparative genomic analysis of the eight-membered ring cystine knot-containing bone morphogenetic protein antagonists. (PubMed id 14525956)1 Avsian-Kretchmer O. and Hsueh A.J. (2004)
  6. The activity of the Nodal antagonist Cerl-2 in the mouse node is required for correct L/R body axis. (PubMed id 15466485)1 Marques S....Belo J.A. (2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  8. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
  9. CER1 is a common target of WNT and NODAL signaling pathways in human embryonic stem cells. (PubMed id 16596263)9 Katoh M. and Katoh M. (2006)
  10. Comparative genomics on Norrie disease gene. (PubMed id 15806314)9 Katoh M. and Katoh M. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 199699 HGNC: 26780 AceView: FLJ38607 Ensembl:ENSG00000179284 euGenes: HUgn199699
ECgene: DAND5 H-InvDB: DAND5

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for DAND5 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for DAND5 gene:
Search GeneIP for patents involving DAND5

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

 
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Sirion Biotech Customized:
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GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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VWF
(GIFTS: 73)
von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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