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Aliases for DAND5 Gene

Aliases for DAND5 Gene

  • DAN Domain Family Member 5, BMP Antagonist 2 3
  • Cysteine Knot Superfamily 1, BMP Antagonist 3 3 4
  • DAN Domain Family, Member 5 2 3
  • Cerberus-Like Protein 2 3 4
  • Gremlin-3 3 4
  • CKTSF1B3 3 4
  • Cerl-2 3 4
  • GREM3 3 4
  • CER2 3 4
  • SP1 3 4
  • Cerberus-Like 2 3
  • Cerberus 2 3
  • CERL2 3
  • DANTE 3
  • CRL2 3
  • COCO 3

External Ids for DAND5 Gene

Previous GeneCards Identifiers for DAND5 Gene

  • GC19P012945
  • GC19P013081
  • GC19P012652

Summaries for DAND5 Gene

Entrez Gene Summary for DAND5 Gene

  • This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to bind Nodal and to inhibit the Nodal signaling pathway which patterns left/right body asymmetry. [provided by RefSeq, Jul 2008]

GeneCards Summary for DAND5 Gene

DAND5 (DAN Domain Family Member 5, BMP Antagonist) is a Protein Coding gene. Diseases associated with DAND5 include morpheaform basal cell carcinoma and infiltrative basal cell carcinoma. Among its related pathways are Signaling by GPCR and Akt Signaling. GO annotations related to this gene include morphogen activity. An important paralog of this gene is CER1.

UniProtKB/Swiss-Prot for DAND5 Gene

  • Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAND5 Gene

Genomics for DAND5 Gene

Regulatory Elements for DAND5 Gene

Genomic Location for DAND5 Gene

Chromosome:
19
Start:
12,965,159 bp from pter
End:
12,974,762 bp from pter
Size:
9,604 bases
Orientation:
Plus strand

Genomic View for DAND5 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAND5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAND5 Gene

Proteins for DAND5 Gene

  • Protein details for DAND5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N907-DAND5_HUMAN
    Recommended name:
    DAN domain family member 5
    Protein Accession:
    Q8N907

    Protein attributes for DAND5 Gene

    Size:
    189 amino acids
    Molecular mass:
    20180 Da
    Quaternary structure:
    No Data Available

neXtProt entry for DAND5 Gene

Proteomics data for DAND5 Gene at MOPED

Post-translational modifications for DAND5 Gene

  • Glycosylation at Asn 38
  • Modification sites at PhosphoSitePlus

Other Protein References for DAND5 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DAND5 Gene

Domains & Families for DAND5 Gene

Protein Domains for DAND5 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DAND5 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8N907

UniProtKB/Swiss-Prot:

DAND5_HUMAN :
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
  • Belongs to the DAN family.
Domain:
  • Contains 1 CTCK (C-terminal cystine knot-like) domain.
Family:
  • Belongs to the DAN family.
genes like me logo Genes that share domains with DAND5: view

No data available for Gene Families for DAND5 Gene

Function for DAND5 Gene

Molecular function for DAND5 Gene

UniProtKB/Swiss-Prot Function:
Seems to play a role in the correct specification of the left-right axis. May antagonize NODAL and BMP4 signaling. Cystine knot-containing proteins play important roles during development, organogenesis, tissue growth and differentiation (By similarity).

Gene Ontology (GO) - Molecular Function for DAND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0016015 morphogen activity ISS --
genes like me logo Genes that share ontologies with DAND5: view
genes like me logo Genes that share phenotypes with DAND5: view

Animal Model Products

Transcription Factor Targets for DAND5 Gene

Selected GeneGlobe predicted Target genes for DAND5

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAND5

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models and HOMER Transcription for DAND5 Gene

Localization for DAND5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAND5 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAND5 Gene COMPARTMENTS Subcellular localization image for DAND5 gene
Compartment Confidence
extracellular 4
cytoskeleton 1
mitochondrion 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for DAND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region NAS 15466485
genes like me logo Genes that share ontologies with DAND5: view

Pathways & Interactions for DAND5 Gene

genes like me logo Genes that share pathways with DAND5: view

Interacting Proteins for DAND5 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000323155%0d%0a9606.ENSP00000221496%0d%0a9606.ENSP00000247005%0d%0a9606.ENSP00000355785%0d%0a9606.ENSP00000363489%0d%0a
Selected Interacting proteins: ENSP00000323155 for DAND5 Gene via STRING

Gene Ontology (GO) - Biological Process for DAND5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003140 determination of left/right asymmetry in lateral mesoderm ISS --
GO:0003281 ventricular septum development ISS --
GO:0003283 atrial septum development ISS --
GO:0007368 determination of left/right symmetry --
GO:0017015 regulation of transforming growth factor beta receptor signaling pathway --
genes like me logo Genes that share ontologies with DAND5: view

No data available for SIGNOR curated interactions for DAND5 Gene

Drugs & Compounds for DAND5 Gene

(1) Drugs for DAND5 Gene - From: NovoSeek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
cysteine Nutra 143
genes like me logo Genes that share compounds with DAND5: view

Transcripts for DAND5 Gene

mRNA/cDNA for DAND5 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(5) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DAND5 Gene

DAN domain family member 5, BMP antagonist:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAND5

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAND5 Gene

No ASD Table

Relevant External Links for DAND5 Gene

GeneLoc Exon Structure for
DAND5
ECgene alternative splicing isoforms for
DAND5

Expression for DAND5 Gene

mRNA expression in normal human tissues for DAND5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAND5 Gene

This gene is overexpressed in Heart - Left Ventricle (x15.9) and Heart - Atrial Appendage (x13.2).

Protein differential expression in normal tissues from HIPED for DAND5 Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DAND5 Gene



SOURCE GeneReport for Unigene cluster for DAND5 Gene Hs.331981

genes like me logo Genes that share expression patterns with DAND5: view

Protein tissue co-expression partners for DAND5 Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DAND5 Gene

Orthologs for DAND5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DAND5 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DAND5 35
  • 77.43 (n)
  • 66.14 (a)
DAND5 36
  • 64 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dand5 35
  • 72.34 (n)
  • 64.29 (a)
Dand5 16
Dand5 36
  • 53 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DAND5 35
  • 99.47 (n)
  • 98.94 (a)
DAND5 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dand5 35
  • 72.89 (n)
  • 65.38 (a)
oppossum
(Monodelphis domestica)
Mammalia DAND5 36
  • 39 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAND5 36
  • 41 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dand5 36
  • 19 (a)
OneToMany
Species with no ortholog for DAND5:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DAND5 Gene

ENSEMBL:
Gene Tree for DAND5 (if available)
TreeFam:
Gene Tree for DAND5 (if available)

Paralogs for DAND5 Gene

Paralogs for DAND5 Gene

genes like me logo Genes that share paralogs with DAND5: view

Variants for DAND5 Gene

Sequence variations from dbSNP and Humsavar for DAND5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs4804745 -- 12,973,089(-) gtcag(C/G)agatc intron-variant
rs4804746 -- 12,973,069(-) CTGGC(C/T)AACAC intron-variant
rs5827168 -- 12,974,530(-) TTGGG(-/T)TTTTT utr-variant-3-prime
rs7248481 -- 12,973,153(+) CACCG(C/T)GCCCG intron-variant
rs7250142 -- 12,969,140(+) gtgcc(C/T)ggcca upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DAND5 Gene

Variant ID Type Subtype PubMed ID
nsv911082 CNV Loss 21882294
nsv833754 CNV Loss 17160897
nsv911085 CNV Loss 21882294
nsv911086 CNV Loss 21882294

Variation tolerance for DAND5 Gene

Residual Variation Intolerance Score: 55.96% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.58; 12.57% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAND5 Gene

HapMap Linkage Disequilibrium report
DAND5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAND5 Gene

Disorders for DAND5 Gene

MalaCards: The human disease database

(4) MalaCards diseases for DAND5 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
morpheaform basal cell carcinoma
  • cicatricial basal-cell carcinoma
infiltrative basal cell carcinoma
  • skin infiltrating basal cell carcinoma
norrie disease
  • anderson-warburg syndrome
malignant syringoma
  • microcystic adnexal carcinoma
- elite association
Search DAND5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DAND5

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAND5
genes like me logo Genes that share disorders with DAND5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAND5 Gene

Publications for DAND5 Gene

  1. Identification and characterization of human CKTSF1B2 and CKTSF1B3 genes in silico. (PMID: 15254711) Katoh M. … Katoh M. (Oncol. Rep. 2004) 2 23 67
  2. CER1 is a common target of WNT and NODAL signaling pathways in human embryonic stem cells. (PMID: 16596263) Katoh M. … Katoh M. (Int. J. Mol. Med. 2006) 23 67
  3. Comparative genomics on Norrie disease gene. (PMID: 15806314) Katoh M. … Katoh M. (Int. J. Mol. Med. 2005) 23 67
  4. Molecular cloning of cDNA for SPase, a monkey cathepsin L orthologue. (PMID: 16147867) Nishinaka T. … Chiu R. (DNA Seq. 2005) 23 67
  5. Collagen Ialpha1 Sp1 polymorphism, bone mass, and bone turnover in healthy French premenopausal women: the OFELY study. (PMID: 9610745) Garnero P. … Delmas P.D. (J. Bone Miner. Res. 1998) 23 67

Products for DAND5 Gene

Sources for DAND5 Gene

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