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DANCR Gene

RNA gene   GIFtS: 23
GCID: GC04P053588

Differentiation Antagonizing Non-Protein Coding RNA

(Previous names: KIAA0114, small nucleolar RNA host gene 13 (non-protein...)
(Previous symbols: KIAA0114, SNHG13)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Subcategory (RNA class): processed_transcript

Quality score for this RNA gene is 3

Aliases
Differentiation Antagonizing Non-Protein Coding RNA1 2 3     Anti-Differentiation NcRNA1
KIAA01141 2 3 5     Small Nucleolar RNA Host Gene 13 (Non-Protein Coding)1
SNHG131 2 3     AGU22
ANCR2 3 5     Anti-Differentiation NcRNA Protein3
Adipogenesis Up-Regulated Transcript 21     Small Nucleolar RNA Host Gene Protein 133

External Ids:    HGNC: 289641   Entrez Gene: 572912   Ensembl: ENSG000002269507   OMIM: 6146255   UniProtKB: P0C8643   

Export aliases for DANCR gene to outside databases

Previous GC identifers: GC04P053582 GC04P053584


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DANCR Gene:
DANCR (differentiation antagonizing non-protein coding RNA) is an RNA gene, and is affiliated with the processed_transcript RNA class.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Search for regulatory transcription factor binding sites for DANCR
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for DANCR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DANCR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 4q12   Ensembl cytogenetic band:  4q12   HGNC cytogenetic band: 4q12

DANCR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DANCR gene location

GeneLoc information about chromosome 4         GeneLoc Exon Structure

GeneLoc location for GC04P053588:  view genomic region     (about GC identifiers)

Start:
53,578,597 bp from pter      End:
53,586,518 bp from pter
Size:
7,922 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for DANCR

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DANCR_HUMAN, P0C864 (See protein sequence)
Recommended Name: Putative uncharacterized protein DANCR  
Size: 163 amino acids; 16785 Da
Caution: Product of a dubious CDS prediction. May be a non-coding RNA (PubMed:22302877)

Explore the universe of human proteins at neXtProt for DANCR: NX_P0C864

Explore proteomics data for DANCR at MOPED


See DANCR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB


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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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HGNC Gene Families:
LNCRNA: Long non-coding RNAs

ProtoNet protein and cluster: P0C864


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Phenotypes:
     1 GenomeRNAi human phenotype for DANCR:
 Increased gamma-H2AX phosphory 

Animal Models:
   genOway: Develop your customized and physiologically relevant rodent model for DANCR

miRNA
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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DANCR
Interactions:

    Search GeneGlobe Interaction Network for DANCR

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000411630(processed_transcript) ENST00000441504(processed_transcript) ENST00000425653(processed_transcript) ENST00000444958(processed_transcript)
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GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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Expression evidence for DANCR:none

DANCR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: AGATTATATG
DANCR Expression
About this image

DANCR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DANCR Protein Expression

UniProtKB/Swiss-Prot: DANCR_HUMAN, P0C864
Tissue specificity: Expressed in keratinocytes

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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for DANCR gene from 1 species (see representative species )    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dancr5 RIKEN cDNA 2700023E23 gene   --   5 (39.38 cM) 74093060 


ENSEMBL Gene Tree for DANCR (if available)
TreeFam Gene Tree for DANCR (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DANCR (see all 13)    About this table                                 

Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 4 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1437145841,2
--53576644(+) TCATTC/GAATTG 1 -- us2k10--------
rs1462390751,2
--53576712(+) ACACAA/TATATA 1 -- us2k10--------
rs1161273901,2
C,F--53576803(+) TGCTAG/AGTTGC 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1501846311,2
--53580058(+) GACTTA/GCTACA 1 -- nc-transcript-variant0--------
rs100332181,2
C,F--53580194(+) TGACTA/GACAAC 1 -- nc-transcript-variant1Minor allele frequency- G:0.05EA 120
rs1931366301,2
--53580291(+) ATAAAC/TTTACT 1 -- nc-transcript-variant0--------
rs1846174591,2
--53580341(+) CCTTAC/TAGATT 1 -- ds50010--------
rs1882367491,2
--53580379(+) ATGGAA/TTAGTG 1 -- ds50010--------
rs801018251,2
F--53580595(+) GAGCCT/CAAGAA 1 -- ds50011Minor allele frequency- C:0.02WA 118
rs1388317121,2
--53580661(+) GTGTGA/TCTATG 1 -- ds50010--------

HapMap Linkage Disequilibrium report for DANCR (53578597 - 53586518 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for DANCR: --
Site Specific Mutation Identification with PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing DANCR
DNA2.0 Custom Variant and Variant Library Synthesis for DANCR

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 614625    OMIM disorders: --


Find genes that share disorders with DANCR           About GenesLikeMe


Export disorders for DANCR gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DANCR gene integrated from 10 sources:
(articles sorted by number of sources associating them with DANCR)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Suppression of progenitor differentiation requires the long noncoding RNA ANCR. (PubMed id 22302877)1, 2, 3 Kretz M.... Khavari P.A. (Genes Dev. 2012)
  2. Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1. (PubMed id 7788527)1, 2, 3 Nagase T.... Nomura N. (DNA Res. 1995)
  3. Transcripts of unknown function in multiple-signaling pathways involved in human stem cell differentiation. (PubMed id 19531736)1, 3 Kikuchi K.... Aizawa Y. (Nucleic Acids Res. 2009)
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  5. Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. (PubMed id 11752456)1, 2 Xu X.R.... Han Z.G. (Proc. Natl. Acad. Sci. U.S.A. 2001)
  6. Downregulated LncRNA-ANCR promotes osteoblast differentiation by targeting EZH2 and regulating Runx2 expression. (PubMed id 23438432)1 Zhu L. and Xu P.C. (Biochem. Biophys. Res. Commun. 2013)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  8. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 57291 HGNC: 28964 Ensembl:ENSG00000226950 euGenes: HUgn57291 ECgene: DANCR
H-InvDB: DANCR

(According to HUGE)
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HUGE: KIAA0114

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DANCR Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DANCR gene:
Search GeneIP for patents involving DANCR

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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