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Aliases for DALRD3 Gene

Aliases for DALRD3 Gene

  • DALR Anticodon Binding Domain Containing 3 2 3 5

External Ids for DALRD3 Gene

Previous GeneCards Identifiers for DALRD3 Gene

  • GC03M049029
  • GC03M049055
  • GC03M049059
  • GC03M049062
  • GC03M049063
  • GC03M049064
  • GC03M049065
  • GC03M049066
  • GC03M049068
  • GC03M049073
  • GC03M049076

Summaries for DALRD3 Gene

Entrez Gene Summary for DALRD3 Gene

  • The exact function of this gene is not known. It encodes a protein with a DALR anticodon binding domain similar to that of class Ia aminoacyl tRNA synthetases. This gene is located in a cluster of genes (with a complex sense-anti-sense genome architecture) on chromosome 3, and contains two micro RNA (miRNA) precursors (mir-425 and mir-191) in one of its introns. Preferential expression of this gene (the miRNAs and other genes in the cluster) in testis suggests a role of this gene in spermatogenesis (PMID:19906709). [provided by RefSeq, Feb 2013]

GeneCards Summary for DALRD3 Gene

DALRD3 (DALR Anticodon Binding Domain Containing 3) is a Protein Coding gene. GO annotations related to this gene include nucleotide binding and arginine-tRNA ligase activity.

Additional gene information for DALRD3 Gene

No data available for CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DALRD3 Gene

Genomics for DALRD3 Gene

Regulatory Elements for DALRD3 Gene

Enhancers for DALRD3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH03H049338 1.9 FANTOM5 ENCODE dbSUPER 25.6 -323.8 -323757 14.7 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 AMT QRICH1 ATRIP ENSG00000235236 WDR6 RBM6 BSN-AS1 DALRD3 RBM5 IP6K2
GH03H049409 1.6 Ensembl ENCODE dbSUPER 12.1 -391.5 -391514 8.9 HDGF PKNOX1 FOXA2 ARNT ARID4B SIN3A DMAP1 YY1 SLC30A9 ZNF766 AMT QRICH1 CCDC71 ATRIP WDR6 SEMA3F-AS1 DALRD3 FAM212A RBM5 DAG1
GH03H048085 1.8 FANTOM5 ENCODE dbSUPER 9.8 +934.4 934393 5.3 FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC MEF2D SSRP1 ATRIP DHX30 ENSG00000235236 SETD2 ZNF589 PTPN23 TMEM89 KLHL18 ENSG00000260236 BOLA2P2
GH03H049484 1.4 Ensembl ENCODE dbSUPER 11.2 -462.9 -462944 1.9 FOXA2 MLX ZFP64 ARID4B THRB RARA CREM THAP11 HMG20B ZNF680 AMT ENSG00000235236 ENSG00000230454 WDR6 ENSG00000223343 BSN-AS2 P4HTM RBM6 IP6K2 RBM5
GH03H049016 1.4 ENCODE dbSUPER 10.5 +2.0 2033 6.8 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B YY1 WDR6 ENSG00000235236 NICN1 FCF1P2 QRICH1 RBM6 ZNF589 ENSG00000223343 P4HTM AMT
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DALRD3 on UCSC Golden Path with GeneCards custom track

Promoters for DALRD3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000303946 693 2801 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A FEZF1 ZNF2 ZBTB7B

Genomic Locations for DALRD3 Gene

Genomic Locations for DALRD3 Gene
chr3:49,015,488-49,022,293
(GRCh38/hg38)
Size:
6,806 bases
Orientation:
Minus strand
chr3:49,052,435-49,059,726
(GRCh37/hg19)

Genomic View for DALRD3 Gene

Genes around DALRD3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DALRD3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DALRD3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DALRD3 Gene

Proteins for DALRD3 Gene

  • Protein details for DALRD3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5D0E6-DALD3_HUMAN
    Recommended name:
    DALR anticodon-binding domain-containing protein 3
    Protein Accession:
    Q5D0E6
    Secondary Accessions:
    • Q7Z5S7
    • Q86WY1
    • Q8N105
    • Q8NA89
    • Q9NVU8

    Protein attributes for DALRD3 Gene

    Size:
    543 amino acids
    Molecular mass:
    59363 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for DALRD3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DALRD3 Gene

Post-translational modifications for DALRD3 Gene

  • Ubiquitination at posLast=219219
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for DALRD3 Gene

Domains & Families for DALRD3 Gene

Gene Families for DALRD3 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for DALRD3 Gene

Suggested Antigen Peptide Sequences for DALRD3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with DALRD3: view

No data available for UniProtKB/Swiss-Prot for DALRD3 Gene

Function for DALRD3 Gene

Phenotypes From GWAS Catalog for DALRD3 Gene

Gene Ontology (GO) - Molecular Function for DALRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004812 aminoacyl-tRNA ligase activity IEA --
GO:0004814 arginine-tRNA ligase activity IEA --
GO:0005515 protein binding IPI 25416956
GO:0005524 ATP binding IEA --
genes like me logo Genes that share ontologies with DALRD3: view

Phenotypes for DALRD3 Gene

GenomeRNAi human phenotypes for DALRD3:
genes like me logo Genes that share phenotypes with DALRD3: view

miRNA for DALRD3 Gene

miRTarBase miRNAs that target DALRD3

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for DALRD3 Gene

Localization for DALRD3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DALRD3 gene
Compartment Confidence
nucleus 3
cytosol 3
extracellular 1
mitochondrion 1
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (2)
  • Nuclear bodies (2)
  • Nucleoplasm (2)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DALRD3 Gene

Pathways & Interactions for DALRD3 Gene

SuperPathways for DALRD3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DALRD3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006418 tRNA aminoacylation for protein translation IEA --
GO:0006420 arginyl-tRNA aminoacylation IEA --
genes like me logo Genes that share ontologies with DALRD3: view

No data available for Pathways by source and SIGNOR curated interactions for DALRD3 Gene

Drugs & Compounds for DALRD3 Gene

No Compound Related Data Available

Transcripts for DALRD3 Gene

Unigene Clusters for DALRD3 Gene

DALR anticodon binding domain containing 3:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DALRD3 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b · 4c ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11a · 11b · 11c ^ 12a · 12b ^ 13
SP1:
SP2: -
SP3: - -
SP4: -
SP5:
SP6: -
SP7:

Relevant External Links for DALRD3 Gene

GeneLoc Exon Structure for
DALRD3
ECgene alternative splicing isoforms for
DALRD3

Expression for DALRD3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DALRD3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DALRD3 Gene

This gene is overexpressed in Plasma (64.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DALRD3 Gene



Protein tissue co-expression partners for DALRD3 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DALRD3 Gene:

DALRD3

SOURCE GeneReport for Unigene cluster for DALRD3 Gene:

Hs.708076

Evidence on tissue expression from TISSUES for DALRD3 Gene

  • Nervous system(4.6)
  • Blood(4)
genes like me logo Genes that share expression patterns with DALRD3: view

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DALRD3 Gene

Orthologs for DALRD3 Gene

This gene was present in the common ancestor of animals.

Orthologs for DALRD3 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia DALRD3 33 34
  • 83.03 (n)
cow
(Bos Taurus)
Mammalia DALRD3 33 34
  • 81.1 (n)
mouse
(Mus musculus)
Mammalia Dalrd3 33 16 34
  • 79.8 (n)
rat
(Rattus norvegicus)
Mammalia Dalrd3 33
  • 79.62 (n)
oppossum
(Monodelphis domestica)
Mammalia DALRD3 34
  • 57 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DALRD3 34
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves DALRD3 33 34
  • 62.82 (n)
lizard
(Anolis carolinensis)
Reptilia DALRD3 34
  • 45 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dalrd3 33 34
  • 53.35 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG8097 34
  • 22 (a)
OneToOne
Species where no ortholog for DALRD3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DALRD3 Gene

ENSEMBL:
Gene Tree for DALRD3 (if available)
TreeFam:
Gene Tree for DALRD3 (if available)

Paralogs for DALRD3 Gene

No data available for Paralogs for DALRD3 Gene

Variants for DALRD3 Gene

Sequence variations from dbSNP and Humsavar for DALRD3 Gene

SNP ID Clin Chr 03 pos Sequence Context AA Info Type
rs121918134 Pathogenic 49,022,497(+) TGCTC(A/C/G)GCCCC upstream-variant-2KB, reference, missense
rs121918135 Pathogenic 49,022,903(+) AGACC(C/G)GACCG upstream-variant-2KB, reference, missense
rs121918136 Pathogenic 49,022,146(+) AGCCA(C/T)GGCCA intron-variant, upstream-variant-2KB, reference, missense
rs567032648 Likely pathogenic 49,022,175(+) GCTTG(C/G/T)ACCGA intron-variant, upstream-variant-2KB, reference, missense
rs746835381 Likely pathogenic 49,023,106(+) GTAAC(-/TG)GAGCT upstream-variant-2KB, reference, frameshift-variant

Structural Variations from Database of Genomic Variants (DGV) for DALRD3 Gene

Variant ID Type Subtype PubMed ID
nsv954488 CNV deletion 24416366

Variation tolerance for DALRD3 Gene

Residual Variation Intolerance Score: 20.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.73; 15.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DALRD3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DALRD3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DALRD3 Gene

Disorders for DALRD3 Gene

Relevant External Links for DALRD3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DALRD3

No disorders were found for DALRD3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DALRD3 Gene

Publications for DALRD3 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland SL … Hayden MR (Human molecular genetics 2014) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for DALRD3 Gene

Sources for DALRD3 Gene

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