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DAK Gene

protein-coding   GIFtS: 56
GCID: GC11P061100

Dihydroxyacetone Kinase 2 Homolog (S. Cerevisiae)

(Previous name: dihydroxyacetone kinase 2 homolog (yeast))
  Search for DAK
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dihydroxyacetone Kinase 2 Homolog (S. Cerevisiae)1 2     DHA Kinase2
Dihydroxyacetone Kinase 2 Homolog (Yeast)1     Dha Kinase/FMN Cyclase2
NET452     FAD-AMP Lyase Cyclic FMN Forming2
ATP-Dependent Dihydroxyacetone Kinase2     FAD-AMP Lyase Cyclizing2
Bifunctional ATP-Dependent Dihydroxyacetone Kinase/FAD-AMP Lyase
(Cyclizing)2
     Glycerone Kinase2

External Ids:    HGNC: 245521   Entrez Gene: 260072   Ensembl: ENSG000001494767   UniProtKB: Q3LXA33   

Export aliases for DAK gene to outside databases

Previous GC identifers: GC11P060858 GC11P057428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAK Gene:
This gene is a member of the family of dihydroxyacetone kinases, which have a protein structure distinct from
other kinases. The product of this gene phosphorylates dihydroxyacetone, and also catalyzes the formation of
riboflavin 4',5'-phosphate (aka cyclin FMN) from FAD. Several alternatively spliced transcript variants have been
identified, but the full-length nature of only one has been determined. (provided by RefSeq, Jul 2008)

GeneCards Summary for DAK Gene:
DAK (dihydroxyacetone kinase 2 homolog (S. cerevisiae)) is a protein-coding gene. GO annotations related to this gene include triokinase activity and glycerone kinase activity.

UniProtKB/Swiss-Prot: DHAK_HUMAN, Q3LXA3
Function: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of
ribonucleoside diphosphate-X compounds among which FAD is the best substrate

Gene Wiki entry for DAK Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAK gene promoter:
         Tal-1   p53   CUTL1   Nkx2-5   Tal-1beta   E47   STAT3   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAK promoter sequence
   Search Chromatin IP Primers for DAK

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAK


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.2

DAK Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAK gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P061100:  view genomic region     (about GC identifiers)

Start:
61,100,654 bp from pter      End:
61,120,767 bp from pter
Size:
20,114 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DHAK_HUMAN, Q3LXA3 (See protein sequence)
Recommended Name: Bifunctional ATP-dependent dihydroxyacetone kinase/FAD-AMP lyase (cyclizing)  
Size: 575 amino acids; 58947 Da
Cofactor: Magnesium (By similarity)
Cofactor: Manganese or cobalt; for FAD-AMP lyase activity (By similarity)
Subunit: Homodimer (By similarity)
Secondary accessions: Q53EQ9 Q9BVA7 Q9H895

Explore the universe of human proteins at neXtProt for DAK: NX_Q3LXA3

Explore proteomics data for DAK at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys372, Lys522
  • Modification sites at PhosphoSitePlus

  • See DAK Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056348.2  
    ENSEMBL proteins: 
     ENSP00000378360   ENSP00000431844   ENSP00000434405   ENSP00000432539   ENSP00000459382  
    Reactome Protein details: Q3LXA3

    DAK Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR012734 DhaK_ATP
     IPR004006 Dak1
     IPR004007 DhaL_dom

    Graphical View of Domain Structure for InterPro Entry Q3LXA3

    ProtoNet protein and cluster: Q3LXA3

    2 Blocks protein domains:
    IPB004006 Dak kinase domain
    IPB004007 Dak phosphatase domain


    UniProtKB/Swiss-Prot: DHAK_HUMAN, Q3LXA3
    Similarity: Belongs to the dihydroxyacetone kinase (DAK) family
    Similarity: Contains 1 DhaK domain
    Similarity: Contains 1 DhaL domain


    Find genes that share domains with DAK           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DHAK_HUMAN, Q3LXA3
    Function: Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde, and the splitting of
    ribonucleoside diphosphate-X compounds among which FAD is the best substrate
    Catalytic activity: ATP + glycerone = ADP + glycerone phosphate
    Catalytic activity: ATP + D-glyceraldehyde = ADP + D-glyceraldehyde 3-phosphate
    Catalytic activity: FAD = AMP + riboflavin cyclic-4',5'-phosphate
    Enzyme regulation: Each activity is inhibited by the substrate(s) of the other
    Biophysicochemical properties: Kinetic parameters: KM=0.5 uM for dihydroxyacetone; KM=11 uM for glyceraldehyde; pH
    dependence: Optimum pH is 6.6;

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004371glycerone kinase activity IDA16289032
    GO:0005524ATP binding IEA--
    GO:0034012FAD-AMP lyase (cyclizing) activity IDA16289032
    GO:0046872metal ion binding IEA--
    GO:0050354triokinase activity IDA4688871
         
    Find genes that share ontologies with DAK           About GenesLikeMe


    Animal Models:
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    miRTarBase miRNAs that target DAK:
    hsa-mir-26b-5p (MIRT029269)

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    6 qRT-PCR Assays for microRNAs that regulate DAK:
    hsa-miR-3934 hsa-miR-3650 hsa-miR-1237 hsa-miR-513a-5p hsa-miR-29a* hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidDAK 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol4
    extracellular1
    mitochondrion1
    nucleus1
    peroxisome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005829cytosol TAS--
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with DAK           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAK About    
    See pathways by source

    SuperPathContained pathways About
    1RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways0.47
    RIG-I-like receptor signaling pathway0.47
    2Carbon metabolism
    Carbon metabolism0.38
    3Metabolism
    Metabolic pathways0.38
    4Glycerolipid metabolism
    Glycerolipid metabolism


    Find genes that share SuperPaths with DAK           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for DAK
        RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways


    4 Kegg Pathways  (Kegg details for DAK):
        Glycerolipid metabolism
    Metabolic pathways
    Carbon metabolism
    RIG-I-like receptor signaling pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including DAK: 
              Antiviral Response in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for DAK

    Selected Interacting proteins for DAK (Q3LXA33) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PIK3R4Q995703I2D: score=4 
    ADCK3Q8NI603I2D: score=1 
    ATICP319393I2D: score=1 
    ATP6V0D1P614213I2D: score=1 
    DLSTP369573I2D: score=1 
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006071glycerol metabolic process IEA--
    GO:0044262cellular carbohydrate metabolic process IDA16289032
    GO:0045087innate immune response TAS--
    GO:0045088regulation of innate immune response IDA16289032
    GO:0046835carbohydrate phosphorylation IDA4688871

    Find genes that share ontologies with DAK           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAK (DHAK)

    4 HMDB Compounds for DAK    About this table
    CompoundSynonyms CAS #PubMed Ids
    ADPadenosindiphosphorsaeure (see all 8)58-64-0--
    Adenosine triphosphate5'-(tetrahydrogen triphosphate) Adenosine (see all 24)56-65-5--
    Dihydroxyacetone1,3-Dihydroxy-2-propanone (see all 21)96-26-4--
    Dihydroxyacetone phosphate1,3-Dihydroxy-2-propanone phosphate (see all 17)57-04-5--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DAK gene: 
    NM_015533.3  

    Unigene Cluster for DAK:

    Dihydroxyacetone kinase 2 homolog (S. cerevisiae)
    Hs.6278  [show with all ESTs]
    Unigene Representative Sequence: NM_015533
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 21):
    ENST00000394900(uc001nre.3) ENST00000531820 ENST00000530456 ENST00000532173
    ENST00000530057 ENST00000525170 ENST00000529121 ENST00000529620 ENST00000533393
    ENST00000524968 ENST00000529479(uc009ynm.1) ENST00000529092 ENST00000533853
    ENST00000524953 ENST00000534134 ENST00000534370 ENST00000528061 ENST00000534084

    miRNA
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    6 qRT-PCR Assays for microRNAs that regulate DAK:
    hsa-miR-3934 hsa-miR-3650 hsa-miR-1237 hsa-miR-513a-5p hsa-miR-29a* hsa-miR-4294
    SwitchGear 3'UTR luciferase reporter plasmidDAK 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: DAK (NM_015533)
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      QuantiTect SYBR Green Assays in human, mouse, rat DAK
      QuantiFast Probe-based Assays in human, mouse, rat DAK

    Additional mRNA sequence: 

    AK023915.1 AK094516.1 AK223580.1 AK308553.1 AL110260.1 BC001341.1 BC120929.1 DQ138290.1 
    DQ344550.1 

    Selected DOTS entries (see all 31):

    DT.100887611  DT.95291946  DT.100794636  DT.100692202  DT.100794639  DT.409045  DT.100794632  DT.100794637 
    DT.95209797  DT.120694308  DT.91756060  DT.95306474  DT.100794635  DT.91770183  DT.120694277  DT.120694245 
    DT.91905992  DT.97848309  DT.100030287  DT.100794634  DT.100794640  DT.120694197  DT.120694199  DT.120694208 

    Selected AceView cDNA sequences (see all 279):

    BM561417 CR593561 BQ689581 BE278697 CD358913 BQ687295 BQ056528 BC001341 
    BQ691975 BM477294 BQ928939 BM820361 BQ927594 BG819948 BM820134 BM834565 
    BG120718 BQ006950 BP376283 BQ055300 BQ061010 NM_015533 AI367550 BP368274 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DAK (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b · 8c ^ 9a · 9b ^ 10a · 10b ^ 11a · 11b ·
    SP1:                          -     -     -     -     -     -           -     -                                                           -           -     -   
    SP2:                                      -     -     -     -           -     -                                                           -                     
    SP3:                          -     -     -     -     -     -           -     -                       -     -     -     -     -     -     -     -     -     -   
    SP4:                          -           -     -     -     -           -     -                                                                                 
    SP5:                          -     -     -     -     -     -                 -                                                                                 

    ExUns: 11c ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20 ^ 21a · 21b
    SP1:                    -     -                                                               
    SP2:                                                                                          
    SP3:  -     -     -     -     -     -     -     -     -     -                                 
    SP4:                                                                                          
    SP5:                                                                                          


    ECgene alternative splicing isoforms for DAK

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAK expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGCAAGAA
    DAK Expression
    About this image

    DAK Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAK Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.6278

    UniProtKB/Swiss-Prot: DHAK_HUMAN, Q3LXA3
    Tissue specificity: Detected in erythrocytes (at protein level)

        Pathway & Disease-focused RT2 Profiler PCR Array including DAK: 
              Antiviral Response in human mouse rat

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    QuantiFast Probe-based Assays in human, mouse, rat DAK
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAK

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DAK gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dak1 , 5 dihydroxyacetone kinase 2 homolog (yeast)1, 5 83.59(n)1
    85.39(a)1
      19 (6.60 cM)5
    2259131  NM_145496.11  NP_663471.11 
     105922005 
    chicken
    (Gallus gallus)
    Aves DAK1 dihydroxyacetone kinase 2 homolog (S. cerevisiae) 73.83(n)
    77.41(a)
      426629  XM_424258.4  XP_424258.4 
    lizard
    (Anolis carolinensis)
    Reptilia DAK6
    dihydroxyacetone kinase 2 homolog (S. cerevisiae)
    64(a)
    1 ↔ 1
    GL343235.1(784030-823242)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia dak1 dihydroxyacetone kinase 2 homolog 62.3(n)
    63.64(a)
      779584  XM_002937653.2  XP_002937699.2 
    zebrafish
    (Danio rerio)
    Actinopterygii dak1 dihydroxyacetone kinase 2 homolog (S. cerevisiae) 60.59(n)
    55.96(a)
      793926  NM_001076630.1  NP_001070098.1 
    worm
    (Caenorhabditis elegans)
    Secernentea W02H5.81 W02H5.8 49.38(n)
    43.49(a)
      178730  NM_071323.4  NP_503724.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes DAK26
    DAK16
    Dihydroxyacetone kinase, required for detoxificati...
    Dihydroxyacetone kinase, required for detoxificati...
    33(a)
    33(a)
    many → 1
    many → 1
    VI(23423-25198) YFL053W
    XIII(133475-135229) YML070W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons AT3G177701 AT3G17770 49.03(n)
    43.61(a)
      821045  NM_112658.3  NP_188404.1 
    rice
    (Oryza sativa)
    Liliopsida Os.460882 Oryza sativa (japonica cultivar-group) cDNA clone0 more 75.74(n)    AK119254.1 


    ENSEMBL Gene Tree for DAK (if available)
    TreeFam Gene Tree for DAK (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAK gene
    1 SIMAP similar gene for DAK using alignment to 7 protein entries:     DHAK_HUMAN (see all proteins):
    DKFZp586B1621

    Find genes that share paralogs with DAK           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAK (see all 400)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs127930991,2
    C,A--61102748(+) cttttC/Tcttca 1 -- int1 trp30--------
    rs1829301641,2
    --61102762(+) GCATTA/TTAAGG 1 -- int10--------
    rs1851864211,2
    --61102772(+) GCAAAG/TTAAGG 1 -- int10--------
    rs560466391,2
    C,F--61102882(+) ATAGCA/GCTGGT 1 -- int12Minor allele frequency- G:0.13WA 120
    rs1450724391,2
    --61102897(+) AAACCC/TTCTTC 1 -- int10--------
    rs1399902231,2
    --61103205(+) GCCTCA/TGTTTC 1 -- int10--------
    rs1902901651,2
    --61103301(+) TGCTCC/TTTTTG 1 -- int10--------
    rs1825172621,2
    --61103323(+) GTGCAA/GTGGCG 1 -- int10--------
    rs1871752511,2
    --61103480(+) AGGCTA/GGTCTC 1 -- int10--------
    rs1126300961,2
    F--61103486(+) GTCTCG/AAACTC 1 -- int11Minor allele frequency- A:0.50CSA 2

    HapMap Linkage Disequilibrium report for DAK (61100654 - 61120767 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DAK:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2744588CNV Deletion23290073
    esv2497950CNV Deletion19546169
    esv1969466CNV Deletion18987734
    esv3293CNV Deletion18987735
    esv1545620CNV Deletion17803354
    nsv832177CNV Loss17160897
    esv5881CNV Loss19470904
    nsv428259CNV Gain+Loss18775914

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DAK
    DNA2.0 Custom Variant and Variant Library Synthesis for DAK

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with DAK           About GenesLikeMe

    Genetic Association Database (GAD): DAK
    Human Genome Epidemiology (HuGE) Navigator: DAK (3 documents)

    Export disorders for DAK gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAK gene, integrated from 10 sources (see all 20):
    (articles sorted by number of sources associating them with DAK)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification of human and rat FAD-AMP lyase (cyclic FMN forming) as ATP-dependent dihydroxyacetone kinases. (PubMed id 16289032)1, 2, 9 Cabezas A.... Cameselle J.C. (Biochem. Biophys. Res. Commun. 2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Dihydroxyacetone metabolism by human erythrocytes: demonstration of triokinase activity and its characterization. (PubMed id 4688871)1, 2 Beutler E. and Guinto E. (Blood 1973)
    5. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    6. Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (amp 2012)
    7. A high-throughput approach for measuring temporal changes in the interactome. (PubMed id 22863883)1 Kristensen A.R....Foster L.J. (Nat. Methods 2012)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    9. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    10. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 26007 HGNC: 24552 AceView: DKFZP586B1621 Ensembl:ENSG00000149476 euGenes: HUgn26007
    ECgene: DAK Kegg: 26007 H-InvDB: DAK

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DAK Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DAK gene:
    Search GeneIP for patents involving DAK

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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