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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAGLB Gene

protein-coding   GIFtS: 55
GCID: GC07M006416

Diacylglycerol Lipase, Beta

  Search for DAGLB
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Diacylglycerol Lipase, Beta1 2
DGL-beta2 3
KCCR13L2 3
DAGLBETA2
Sn1-Specific Diacylglycerol Lipase Beta2
EC 3.1.1.-3

External Ids:    HGNC: 289231   Entrez Gene: 2219552   Ensembl: ENSG000001645357   OMIM: 6140165   UniProtKB: Q8NCG73   

Export aliases for DAGLB gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for DAGLB Gene: 
DAGLB (diacylglycerol lipase, beta) is a protein-coding gene. Among its related super-pathways are Signaling by GPCR and Gastrin-CREB signalling pathway via PKC and MAPK. GO annotations related to this gene include triglyceride lipase activity and metal ion binding. An important paralog of this gene is DAGLA.

UniProtKB/Swiss-Prot: DGLB_HUMAN, Q8NCG7
Function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant
endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling
at mature synapses




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000007.13  NT_007819.17  NC_018918.2  NT_079592.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAGLB gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   E47   E2F   E2F-1   Hand1   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): DAGLB promoter sequence
   Search SABiosciences Chromatin IP Primers for DAGLB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAGLB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1   Ensembl cytogenetic band:  7p22.1   HGNC cytogenetic band: 7p22.1

DAGLB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAGLB gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M006416:  view genomic region     (about GC identifiers)

Start:
6,448,747 bp from pter      End:
6,523,821 bp from pter
Size:
75,075 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 6,495,031-6,533,770     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DGLB_HUMAN, Q8NCG7 (See protein sequence)
Recommended Name: Sn1-specific diacylglycerol lipase beta  
Size: 672 amino acids; 73732 Da
Cofactor: Calcium
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAB85017.1; Type=Erroneous initiation;
Secondary accessions: A4D2P3 B3KV90 B4DQU0 Q6PIX3 Q8N2N2 Q8N9S1 Q8TED3 Q8WXE6
Alternative splicing: 4 isoforms:  Q8NCG7-1   Q8NCG7-2   Q8NCG7-3   Q8NCG7-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DAGLB: NX_Q8NCG7

Explore proteomics data for DAGLB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8NCG7

  • DAGLB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DAGLB Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001136408.1  NP_631918.3  

    ENSEMBL proteins: 
     ENSP00000297056   ENSP00000391171   ENSP00000404785   ENSP00000411746   ENSP00000410787  
     ENSP00000416046   ENSP00000408928  
    Reactome Protein details: Q8NCG7
    Human Recombinant Protein Products for DAGLB: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals DAGLB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    DAGLB for ontologies           About GeneDecksing



    DAGLB Antibody Products: 
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    Abcam antibodies for DAGLB
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    LSBio Antibodies in human, mouse, rat for DAGLB 

    Assay Products for DAGLB: 
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    Browse ELISAs at Cloud-Clone Corp. 
    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Diacylglycerol lipase &beta 
    Endocannabinoid turnover

    1 InterPro protein domain:
     IPR002921 Lipase_3

    Graphical View of Domain Structure for InterPro Entry Q8NCG7

    ProtoNet protein and cluster: Q8NCG7

    UniProtKB/Swiss-Prot: DGLB_HUMAN, Q8NCG7
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family


    DAGLB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGLB_HUMAN, Q8NCG7
    Function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant
    endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling
    at mature synapses
    Enzyme regulation: Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by
    RHC80267, a drug that blocks 2-AG formation
    Biophysicochemical properties: Kinetic parameters: KM=74.1 uM for diacylglycerol; Vmax=3.45 nmol/min/mg enzyme; pH
    dependence: Optimum pH is 7.0;

         Enzyme Number (IUBMB): EC 3.1.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004806triglyceride lipase activity IEA--
    GO:0046872metal ion binding IEA--
         
    DAGLB for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DAGLB:
     Lamellipodia and high actin ra 

         3 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Daglb):
     cellular  homeostasis/metabolism  nervous system 

    DAGLB for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Daglbtm1.1Kano for DAGLB

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DAGLB 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DAGLB

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    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DAGLB About   (see all 10)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Development Dopamine D2 receptor transactivation of EGFR
    Development Alpha-2 adrenergic receptor activation of ERK0.66
    5Circadian entrainment
    Retrograde endocannabinoid signaling0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for DAGLB
        Development Alpha-2 adrenergic receptor activation of ERK


    2 Cell Signaling Technology (CST) Pathways for DAGLB
        Ca, cAMP and Lipid Signaling
    Neuroscience

    1 GeneGo (Thomson Reuters) Pathway for DAGLB
        Development Alpha-2 adrenergic receptor activation of ERK

    1 BioSystems Pathway for DAGLB
        N-cadherin signaling events

    5/9        Reactome Pathways for DAGLB (see all 9)
        GPCR downstream signaling
    Hemostasis
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    Arachidonate production from DAG


    1         Kegg Pathway  (Kegg details for DAGLB):
        Retrograde endocannabinoid signaling


    DAGLB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DAGLB

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for DAGLB (Q8NCG72, 3 ENSP000002970564) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    PISDQ9UG563, ENSP000002660954I2D: score=3 STRING: ENSP00000266095
    MGLLENSP000002650524STRING: ENSP00000265052
    UBCENSP000003448184STRING: ENSP00000344818
    --Q5THK32MINT-64527
    About this table

    Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0007405neuroblast proliferation IEA--
    GO:0007596blood coagulation TAS--
    GO:0016042lipid catabolic process IEA--
    GO:0019369arachidonic acid metabolic process IEA--

    DAGLB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for DAGLB:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DAGLB (DGLB)

    10/844 HMDB Compounds for DAGLB (see all 844)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----

    2 IUPHAR Ligands for DAGLB (Diacylglycerol lipase &beta)    About this table 
    LigandTypeActionAffinityPubmed IDs
    tetrahydrolipstatin
    Inhibitor714610053
    RHC80267
    InhibitorInhibition7--

    Search CenterWatch for drugs/clinical trials and news about DAGLB / DGLB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DAGLB gene (2 alternative transcripts): 
    NM_001142936.1  NM_139179.3  

    Unigene Cluster for DAGLB:

    Diacylglycerol lipase, beta
    Hs.487498  [show with all ESTs]
    Unigene Representative Sequence: NM_139179
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000462934(uc003spz.3) ENST00000297056(uc011jwt.2 uc003sqa.3 uc011jwu.2 uc003sqb.3 uc003sqc.3 uc011jwv.2 uc003sqd.4)
    ENST00000482149(uc003spy.3) ENST00000425398 ENST00000436575 ENST00000497308
    ENST00000454738 ENST00000432248 ENST00000479922 ENST00000483716 ENST00000428902
    ENST00000421761(uc011jww.1)
    miRNA
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    Inhib. RNA
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    Additional mRNA sequence: 

    AF450090.1 AK074210.1 AK074584.1 AK074744.1 AK075128.1 AK093958.1 AK122748.1 AK298910.1 
    AK298955.1 BC027603.1 

    16 DOTS entries:

    DT.454036  DT.100814741  DT.102843451  DT.100836425  DT.75151199  DT.100814740  DT.100814746  DT.91923629 
    DT.92427292  DT.100814750  DT.116253  DT.121063009  DT.121063053  DT.444718  DT.100814745  DT.102843452 

    24/842 AceView cDNA sequences (see all 842):

    CA413840 CB131841 BI832887 AU125417 F11015 AI092501 CB144429 AW469393 
    AI870655 AA486516 AA250896 N62663 BM826273 BM782282 BM857077 BM850351 
    BM542267 AA336368 T31683 AA961421 AU125682 AF450090 AA375407 AI224857 

    GeneLoc Exon Structure

    5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DAGLB (see all 12)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
    SP1:                                -                 -     -                                               -           -                                   -   
    SP2:                    -     -     -     -     -     -     -     -     -                                   -           -                                   -   
    SP3:                                -     -     -     -     -     -     -     -                             -           -                                   -   
    SP4:                                                                                                                    -                                   -   
    SP5:                                                                                                                                                        -   

    ExUns: 16 ^ 17
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for DAGLB

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAGLB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GTCTCAATGA
    DAGLB Expression
    About this image


    See DAGLB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAGLB

    SOURCE GeneReport for Unigene cluster: Hs.487498
        SABiosciences Custom PCR Arrays for DAGLB
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAGLB

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DAGLB gene from 6/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Daglb1 , 5 diacylglycerol lipase, beta1, 5 79.79(n)1
    79.34(a)1
      5 (82.19 cM)5
    2318711  NM_144915.31  NP_659164.21 
     1434729475 
    chicken
    (Gallus gallus)
    Aves DAGLB1 diacylglycerol lipase, beta 65.29(n)
    63.12(a)
      416625  NM_001030643.1  NP_001025814.1 
    lizard
    (Anolis carolinensis)
    Reptilia DAGLB6
    --
    Uncharacterized protein
    64(a)
    52(a)
    1 ↔ 1
    possible ortholog
    AAWZ02041552(815-5418)
    GL343507.1(89234-96389)
    zebrafish
    (Danio rerio)
    Actinopterygii daglb1 diacylglycerol lipase, beta 60(n)
    58.86(a)
      565287  XM_688567.5  XP_693659.5 
    mosquito
    (Anopheles gambiae)
    Insecta AgaP_AGAP0121711 AGAP012171-PA 44.69(n)
    32.81(a)
      1280514  XM_320362.4  XP_320362.4 
    worm
    (Caenorhabditis elegans)
    Secernentea F42G9.61 Protein F42G9.6 43.94(n)
    35.85(a)
      3565075  NM_171860.3  NP_741085.1 


    ENSEMBL Gene Tree for DAGLB (if available)
    TreeFam Gene Tree for DAGLB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DAGLB gene
    DAGLA2  
    1 SIMAP similar gene for DAGLB using alignment to 6 protein entries:     DGLB_HUMAN (see all proteins):
    DAGLA

    DAGLB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1379 SNPs in DAGLB are shown (see all 1379)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413915761,2
    --6448278(+) TCCTTC/GAAGAC 2 -- ds50010--------
    rs38135181,2
    C,F--6448359(-) CTGTCG/ATTTGC 2 -- ds50018Minor allele frequency- A:0.14NA WA CSA EA 367
    rs1167934861,2
    F--6448360(+) CAAACG/AACAGG 2 -- ds50011Minor allele frequency- A:0.01WA 118
    rs1504054111,2
    --6448444(+) GCCCAA/GGGTCT 2 -- ds50010--------
    rs38135171,2
    C,F,H--6448532(-) TGGGAA/GAAGAC 2 -- ds500120Minor allele frequency- G:0.05NS EA NA WA 2756
    rs1906655771,2
    --6448550(+) GGTCTC/TTGCTT 2 -- ds50010--------
    rs1436502441,2
    C--6448661(+) GGTTT-/AAAAAAAA 2 -- ds50010--------
    rs1831587581,2
    --6448677(+) GGAAAC/TATCAT 2 -- ds50010--------
    rs1872965131,2
    C--6448709(+) AGTAGC/TGCTAC 2 -- ds50010--------
    rs8365591,2
    C,F,O,H--6448763(-) GTCACG/CATAGT 2 -- ut31 ese336Minor allele frequency- C:0.24EA NA NS WA CSA 3400

    HapMap Linkage Disequilibrium report for DAGLB (6448747 - 6523821 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for DAGLB:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2733926CNV Deletion23290073
    esv2733927CNV Deletion23290073
    nsv436904CNV Insertion17901297
    nsv887428CNV Loss21882294
    esv1914954OTHER Inversion16254605
    nsv7392OTHER Inversion18451855

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DAGLB
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    DAGLB for disorders           About MalaCards
    OMIM gene information: 614016    OMIM disorders: --


    DAGLB for disorders           About GeneDecksing


    Export disorders for DAGLB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAGLB gene, integrated from 9 sources (see all 22):
    (articles sorted by number of sources associating them with DAGLB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)1, 2 Scherer S.W.... Tsui L.-C. (2003)
    5. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. (PubMed id 14610053)1, 2 Bisogno T.... Doherty P. (2003)
    6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (2012)
    7. Global landscape of HIV-human protein complexes. (PubMed id 22190034)1 Jager S....Krogan N.J. (2012)
    8. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    9. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    10. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221955 HGNC: 28923 AceView: KDELR2 Ensembl:ENSG00000164535 euGenes: HUgn221955
    ECgene: DAGLB Kegg: 221955 H-InvDB: DAGLB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAGLB Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DAGLB gene:
    Search GeneIP for patents involving DAGLB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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