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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DAGLB Gene

protein-coding GIFtS: 52
GCID: GC07M006416

diacylglycerol lipase, beta

Search for DAGLB
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Diacylglycerol Lipase, Beta¹ ²
KCCR13L¹ ² ³
DAGLBETA¹ ²
DGL-Beta¹
Sn1-Specific Diacylglycerol Lipase Beta²
EC 3.1.1.-³

External Ids:	HGNC: 28923¹	Entrez Gene: 221955²	Ensembl: ENSG00000164535⁷	OMIM: 614016⁵	UniProtKB: Q8NCG7³

Export aliases for DAGLB gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DGLB_HUMAN, Q8NCG7

Function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant

endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at

mature synapses

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DAGLB gene promoter:
E2F-4 E2F-3a E2F-5 E2F-2 E47 E2F E2F-1 Hand1 En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 4): DAGLB promoter sequence

Search SABiosciences Chromatin IP Primers for DAGLB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAGLB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.1 Ensembl cytogenetic band: 7p22.1 HGNC cytogenetic band: 7p22.1

DAGLB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAGLB gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M006416: view genomic region (about GC identifiers)

Start:	6,448,747 bp from pter	End:	6,523,821 bp from pter
Size:	75,075 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 6,495,031-6,533,770

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DGLB_HUMAN, Q8NCG7 (See protein sequence)

Recommended Name: Sn1-specific diacylglycerol lipase beta

Size: 672 amino acids; 73732 Da

Cofactor: Calcium

Subcellular location: Cell membrane; Multi-pass membrane protein

Sequence caution: Sequence=BAB85017.1; Type=Erroneous initiation;

Secondary accessions: A4D2P3 B3KV90 B4DQU0 Q6PIX3 Q8N2N2 Q8N9S1 Q8TED3 Q8WXE6

Alternative splicing: 4 isoforms: Q8NCG7-1 Q8NCG7-2 Q8NCG7-3 Q8NCG7-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DAGLB: NX_Q8NCG7

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q8NCG7

DAGLB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001136408.1 NP_631918.3

ENSEMBL proteins:

ENSP00000297056 ENSP00000391171 ENSP00000404785 ENSP00000411746 ENSP00000410787

ENSP00000416046 ENSP00000408928

Reactome Protein details: Q8NCG7
Human Recombinant Protein Products for DAGLB:

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	Browse Sino Biological Recombinant Proteins
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	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005886	plasma membrane	TAS	--
GO:0016021	integral to membrane	IEA	--

DAGLB for ontologies About GeneDecksing

DAGLB Antibody Products:

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Assay Products for DAGLB:

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	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DAGLB for domains About GeneDecksing

1 InterPro domain/family:

IPR002921 Lipase_3

Graphical View of Domain Structure for InterPro Entry Q8NCG7

ProtoNet protein and cluster: Q8NCG7

UniProtKB/Swiss-Prot: DGLB_HUMAN, Q8NCG7

Similarity: Belongs to the AB hydrolase superfamily. Lipase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DGLB_HUMAN, Q8NCG7

Function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant

endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at

mature synapses

Enzyme regulation: Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a

drug that blocks 2-AG formation

Biophysicochemical properties: Kinetic parameters: KM=74.1 uM for diacylglycerol; Vmax=3.45 nmol/min/mg enzyme; pH

dependence: Optimum pH is 7.0;

Enzyme Number (IUBMB): EC 3.1.1.-¹

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004806	triglyceride lipase activity	IEA	--
GO:0046872	metal ion binding	IEA	--

DAGLB for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for DAGLB:

Lamellipodia and high actin ra

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Daglb):

cellular

homeostasis/metabolism

nervous system

DAGLB for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Daglb^tm1.1Kano for DAGLB

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DAGLB

miRNA Products:		OriGene 3'-UTR Clone (see all 2): DAGLB Browse MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAGLB (see all 7) OriGene shRNA RFP: DAGLB OriGene siRNA: DAGLB
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAGLB (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DAGLB (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAGLB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

G alpha (q) signalling events

G alpha (q) signalling events

1.00

Gastrin-CREB signalling pathway via PKC and MAPK

0.90

Development_Dopamine D2 receptor transactivation of EGFR

Development_Alpha-2 adrenergic receptor activation of ERK

0.66

Development Alpha-2 adrenergic receptor activation of ERK

0.66

Effects of PIP2 hydrolysis

Effects of PIP2 hydrolysis

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for DAGLB

Development Alpha-2 adrenergic receptor activation of ERK

1 GeneGo (Thomson Reuters) Pathway for DAGLB

Development Alpha-2 adrenergic receptor activation of ERK

1 BioSystems Pathway for DAGLB

N-cadherin signaling events

5/9 Reactome Pathways for DAGLB (see all 9)

	GPCR downstream signaling
	Hemostasis
	Gastrin-CREB signalling pathway via PKC and MAPK
	Signaling by GPCR
	Arachidonate production from DAG

DAGLB for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DAGLB

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

4 Interacting proteins for DAGLB (Q8NCG7^{2, 3} ENSP00000297056⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
PISD	Q9UG56³, ENSP00000266095⁴	I2D: score=3 STRING: ENSP00000266095
MGLL	ENSP00000265052⁴	STRING: ENSP00000265052
UBC	ENSP00000344818⁴	STRING: ENSP00000344818
--	Q5THK3²	MINT-64527

About this table

Gene Ontology (GO): 4 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	--	--
GO:0007596	blood coagulation	TAS	--
GO:0016042	lipid catabolic process	IEA	--
GO:0030168	platelet activation	TAS	--

DAGLB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

EMD Millipore small molecules for DAGLB:
Small Molecule - inhibitor

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DAGLB

10/844 HMDB Compounds for DAGLB (see all 844) About this table

Compound	Synonyms	CAS #	PubMed Ids
DG(16:0e/18:0/0:0)	2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)	--	12486725
Calcium	Ca (see all 2)	7440-70-2	--
DG(14:0/14:0/0:0)	DAG(14:0/14:0) (see all 9)	--	--
DG(14:0/14:1(9Z)/0:0)	DAG(14:0/14:1) (see all 15)	--	--
DG(14:0/15:0/0:0)	Diacylglycerol(29:0) (see all 9)	--	--
DG(14:0/16:0/0:0)	DAG(30:0) (see all 9)	--	--
DG(14:0/16:1(9Z)/0:0)	DG(30:1) (see all 15)	--	--
DG(14:0/18:0/0:0)	DG(14:0/18:0) (see all 9)	--	--
DG(14:0/18:1(11Z)/0:0)	Diacylglycerol (see all 15)	--	--
DG(14:0/18:1(9Z)/0:0)	1-myristoyl-2-oleoyl-sn-glycerol (see all 15)	--	--

Search CenterWatch for drugs/clinical trials and news about DAGLB / DGLB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DAGLB gene (2 alternative transcripts):

NM_001142936.1 NM_139179.3

Unigene Cluster for DAGLB:

Diacylglycerol lipase, beta

Hs.487498 [show with all ESTs]

Unigene Representative Sequence: NM_139179

12 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000462934(uc003spz.3) ENST00000297056(uc011jwt.2 uc003sqa.3 uc011jwu.2 uc003sqb.3 uc003sqc.3 uc011jwv.2 uc003sqd.4)

ENST00000482149(uc003spy.3) ENST00000425398 ENST00000436575 ENST00000497308

ENST00000454738 ENST00000432248 ENST00000479922 ENST00000483716 ENST00000428902

ENST00000421761(uc011jww.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAGLB
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DAGLB
		SwitchGear 3'UTR luciferase reporter plasmid: DAGLB 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAGLB (see all 7) OriGene shRNA RFP: DAGLB OriGene siRNA: DAGLB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAGLB
		Sirion Biotech Custom design and validation of potent shRNA sequences against DAGLB

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAGLB (see all 4) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DAGLB (see all 2) OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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Additional cDNA sequence:

AF450090.1 AK074210.1 AK074584.1 AK074744.1 AK075128.1 AK093958.1 AK122748.1 AK298910.1

AK298955.1 BC027603.1

16 DOTS entries:

DT.454036 DT.100814741 DT.102843451 DT.100836425 DT.75151199 DT.100814740 DT.100814746 DT.91923629

DT.92427292 DT.100814750 DT.116253 DT.121063009 DT.121063053 DT.444718 DT.100814745 DT.102843452

24/842 AceView cDNA sequences (see all 842):

CK429644 CD672698 AI224857 AA988515 CB242880 BQ019744 AI278571 AA250896

BQ447192 BI832887 F11015 AW205904 BP383428 AA682659 BI260540 AA337260

BM663251 CB131841 AW301244 N22130 BE502100 CR607926 BM762319 AW469393

GeneLoc Exon Structure

5/12 Alternative Splicing Database (ASD) splice patterns (SP) for DAGLB (see all 12) About this scheme

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	^	3	^	4a	·	4b	·	4c	^	5	^	6a	·	6b	^	7	^	8a	·	8b	^	9	^	10	^	11a	·	11b	^	12a	·	12b	^	13a	·	13b	^	14	^	15a	·	15b	^
SP1:											-						-		-																-				-												-
SP2:							-		-		-		-		-		-		-		-		-												-				-												-
SP3:											-		-		-		-		-		-		-		-										-				-												-
SP4:																																							-												-
SP5:																																																			-

ExUns:	16	^	17
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for DAGLB

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DAGLB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTCTCAATGA

About this image
See DAGLB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DAGLB

SOURCE GeneReport for Unigene cluster: Hs.487498
SABiosciences Custom PCR Arrays for DAGLB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DAGLB Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAGLB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAGLB

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAGLB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DAGLB gene from 8/23 species (see all 23) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Daglb^{1 , 5}	diacylglycerol lipase, beta^{1, 5}	79.79(n)¹ 79.34(a)¹		5 (82.19 cM)⁵ 231871¹ NM_144915.3¹ NP_659164.2¹ 143472947⁵
chicken (Gallus gallus)	Aves	DAGLB¹	diacylglycerol lipase, beta	65.29(n) 63.12(a)		416625 NM_001030643.1 NP_001025814.1
lizard (Anolis carolinensis)	Reptilia	DAGLB⁶ --	--	63(a) 60(a)	many → 1 many → 1	AAWZ02041552(1062-5418) GL343507.1(90807-95928)
zebrafish (Danio rerio)	Actinopterygii	daglb¹	diacylglycerol lipase, beta	60(n) 58.86(a)		565287 XM_688567.5 XP_693659.5
mosquito (Anopheles gambiae)	Insecta	AgaP_AGAP012171¹	AGAP012171-PA	44.69(n) 32.81(a)		1280514 XM_320362.4 XP_320362.4
worm (Caenorhabditis elegans)	Secernentea	F42G9.6¹	Protein F42G9.6	43.94(n) 35.85(a)		3565075 NM_171860.3 NP_741085.1
thale cress (Arabidopsis thaliana)	eudicotyledons	AT2G42450⁶ AT3G14075⁶ (see all 3)	lipase class 3 family protein (see all 3)	17(a) 12(a) (see all 3)	many ↔ many many ↔ many (see all 3)	2(17672253-17675019) 3(4663569-4667079)
rice (Oryza sativa)	Liliopsida	-- -- (see all 6)	lipase, putative, expressed lipase class 3 family protein, putative, expressed... (see all 6)	16(a) 14(a) (see all 6)	many ↔ many many ↔ many (see all 6)	9(22810710-22813586) 1(11617309-11621509)

ENSEMBL Gene Tree for DAGLB (if available)
TreeFam Gene Tree for DAGLB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DAGLB gene

DAGLA²

1 SIMAP similar gene for DAGLB using alignment to 6 protein entries: DGLB_HUMAN (see all proteins):

DAGLA

DAGLB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs141391576^1,2		--	6448278(+)	`TCCTTC/GAAGAC`	2	--	ds500¹		0	--	--	--	--
rs3813518^1,2	C,F	--	6448359(-)	`CTGTCG/ATTTGC`	2	--	ds500¹		8		NA WA CSA EA	367
rs116793486^1,2		--	6448360(+)	`CAAACG/AACAGG`	2	--	ds500¹		1		WA	118
rs150405411^1,2		--	6448444(+)	`GCCCAA/GGGTCT`	2	--	ds500¹		0	--	--	--	--
rs3813517^1,2	C,F,H	--	6448532(-)	`TGGGAA/GAAGAC`	2	--	ds500¹		20		NS EA NA WA	2756
rs190665577^1,2		--	6448550(+)	`GGTCTC/TTGCTT`	2	--	ds500¹		0	--	--	--	--
rs143650244^1,2	C	--	6448661(+)	`GGTTT-/AAAAAAAA`	2	--	ds500¹		0	--	--	--	--
rs183158758^1,2		--	6448677(+)	`GGAAAC/TATCAT`	2	--	ds500¹		0	--	--	--	--
rs187296513^1,2		--	6448709(+)	`AGTAGC/TGCTAC`	2	--	ds500¹		0	--	--	--	--
rs836559^1,2	C,F,O,H	--	6448763(-)	`GTCACG/CATAGT`	2	--	ut3¹ ese³		36		EA NA NS WA CSA	3400

HapMap Linkage Disequilibrium report for DAGLB (6448747 - 6523821 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for DAGLB
1 Inversion: 37290

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DAGLB for disorders About MalaCards

DAGLB for disorders About GeneDecksing

OMIM gene information: 614016 OMIM disorders: --

Export disorders for DAGLB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DAGLB gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with DAGLB)

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Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)^{1, 2} Scherer S.W.... Tsui L.-C. (2003)
Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. (PubMed id 14610053)^{1, 2} Bisogno T.... Doherty P. (2003)
Global landscape of HIV-human protein complexes. (PubMed id 22190034)¹ Jager S....Krogan N.J. (2012)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)² Olsen J.V....Mann M. (2010)
Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PubMed id 19690332)² Mayya V.... Han D.K. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 221955	HGNC: 28923	AceView: KDELR2	Ensembl:ENSG00000164535	euGenes: HUgn221955
ECgene: DAGLB	H-InvDB: DAGLB

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DAGLB	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DAGLB gene
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Patent Information for DAGLB gene:
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diacylglycerol lipase, beta

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diacylglycerol lipase, beta

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