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Aliases for DAGLB Gene

Aliases for DAGLB Gene

  • Diacylglycerol Lipase Beta 2 3
  • Diacylglycerol Lipase, Beta 2 5
  • DGL-Beta 3 4
  • KCCR13L 3 4
  • EC 3.1.1.- 4
  • DAGLBETA 3

External Ids for DAGLB Gene

Summaries for DAGLB Gene

GeneCards Summary for DAGLB Gene

DAGLB (Diacylglycerol Lipase Beta) is a Protein Coding gene. Diseases associated with DAGLB include hallucinogen dependence. Among its related pathways are Platelet activation, signaling and aggregation and Signaling by GPCR. GO annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is DAGLA.

UniProtKB/Swiss-Prot for DAGLB Gene

  • Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAGLB Gene

Genomics for DAGLB Gene

Regulatory Elements for DAGLB Gene

Promoters for DAGLB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DAGLB on UCSC Golden Path with GeneCards custom track

Genomic Location for DAGLB Gene

Chromosome:
7
Start:
6,409,116 bp from pter
End:
6,484,190 bp from pter
Size:
75,075 bases
Orientation:
Minus strand

Genomic View for DAGLB Gene

Genes around DAGLB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAGLB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAGLB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAGLB Gene

Proteins for DAGLB Gene

  • Protein details for DAGLB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCG7-DGLB_HUMAN
    Recommended name:
    Sn1-specific diacylglycerol lipase beta
    Protein Accession:
    Q8NCG7
    Secondary Accessions:
    • A4D2P3
    • B3KV90
    • B4DQU0
    • Q6PIX3
    • Q8N2N2
    • Q8N9S1
    • Q8TED3
    • Q8WXE6

    Protein attributes for DAGLB Gene

    Size:
    672 amino acids
    Molecular mass:
    73732 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85017.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DAGLB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAGLB Gene

Proteomics data for DAGLB Gene at MOPED

Post-translational modifications for DAGLB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAGLB Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DAGLB (DAGLBETA)

No data available for DME Specific Peptides for DAGLB Gene

Domains & Families for DAGLB Gene

Gene Families for DAGLB Gene

Protein Domains for DAGLB Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NCG7

UniProtKB/Swiss-Prot:

DGLB_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with DAGLB: view

Function for DAGLB Gene

Molecular function for DAGLB Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=74.1 uM for diacylglycerol {ECO:0000269 PubMed:14610053}; Vmax=3.45 nmol/min/mg enzyme {ECO:0000269 PubMed:14610053}; pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:14610053};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

Enzyme Numbers (IUBMB) for DAGLB Gene

Phenotypes for DAGLB Gene

genes like me logo Genes that share phenotypes with DAGLB: view

Animal Models for DAGLB Gene

MGI Knock Outs for DAGLB:

Animal Model Products

miRNA for DAGLB Gene

miRTarBase miRNAs that target DAGLB

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAGLB Gene

Localization for DAGLB Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAGLB Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAGLB Gene COMPARTMENTS Subcellular localization image for DAGLB gene
Compartment Confidence
lysosome 5
plasma membrane 5
vacuole 5

No data available for Gene Ontology (GO) - Cellular Components for DAGLB Gene

Pathways & Interactions for DAGLB Gene

genes like me logo Genes that share pathways with DAGLB: view

Pathways by source for DAGLB Gene

Interacting Proteins for DAGLB Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000297056%0d%0a9606.ENSP00000265052%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000266095%0d%0a
Selected Interacting proteins: Q8NCG7-DGLB_HUMAN ENSP00000297056 for DAGLB Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007596 blood coagulation TAS --
GO:0030168 platelet activation TAS --
genes like me logo Genes that share ontologies with DAGLB: view

No data available for SIGNOR curated interactions for DAGLB Gene

Drugs & Compounds for DAGLB Gene

(3) Drugs for DAGLB Gene - From: IUPHAR, DGIdb, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 52
RHC80267 Pharma Inhibition, Inhibitor 0
calcium Nutra 0

(5) Additional Compounds for DAGLB Gene - From: IUPHAR and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
tetrahydrolipstatin
Inhibition, Inhibitor
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with DAGLB: view

Transcripts for DAGLB Gene

Unigene Clusters for DAGLB Gene

Diacylglycerol lipase, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DAGLB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: -
SP6: - - - - - - -
SP7: - - - -
SP8: - -
SP9: - - - - - - - - - -
SP10:
SP11: -
SP12:

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for DAGLB Gene

GeneLoc Exon Structure for
DAGLB
ECgene alternative splicing isoforms for
DAGLB

Expression for DAGLB Gene

mRNA expression in normal human tissues for DAGLB Gene

Protein differential expression in normal tissues from HIPED for DAGLB Gene

This gene is overexpressed in NK cells (35.8), Breast (11.3), Peripheral blood mononuclear cells (9.1), and Liver (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for DAGLB Gene



SOURCE GeneReport for Unigene cluster for DAGLB Gene Hs.487498

genes like me logo Genes that share expression patterns with DAGLB: view

Protein tissue co-expression partners for DAGLB Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DAGLB Gene

Orthologs for DAGLB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DAGLB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DAGLB 35
  • 81.27 (n)
  • 83.56 (a)
DAGLB 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAGLB 35
  • 83.68 (n)
  • 85.97 (a)
DAGLB 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Daglb 35
  • 79.79 (n)
  • 79.34 (a)
Daglb 16
Daglb 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia LOC100612262 35
  • 99.57 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Daglb 35
  • 79.06 (n)
  • 78.11 (a)
oppossum
(Monodelphis domestica)
Mammalia DAGLB 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves DAGLB 35
  • 64.96 (n)
  • 61.54 (a)
DAGLB 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia daglb 35
  • 62.73 (n)
  • 60.97 (a)
zebrafish
(Danio rerio)
Actinopterygii daglb 35
  • 60 (n)
  • 58.86 (a)
daglb 36
  • 58 (a)
OneToMany
DAGLB (1 of 2) 36
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012171 35
  • 44.09 (n)
  • 33.07 (a)
worm
(Caenorhabditis elegans)
Secernentea F42G9.6 35
  • 44.22 (n)
  • 35.33 (a)
F42G9.6 36
  • 28 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G05790 35
  • 38.57 (n)
  • 30.3 (a)
Species with no ortholog for DAGLB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAGLB Gene

ENSEMBL:
Gene Tree for DAGLB (if available)
TreeFam:
Gene Tree for DAGLB (if available)

Paralogs for DAGLB Gene

Paralogs for DAGLB Gene

(1) SIMAP similar genes for DAGLB Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DAGLB: view

Variants for DAGLB Gene

Sequence variations from dbSNP and Humsavar for DAGLB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs2303361 - 6,409,865(+) CCCCT(C/T)GTGCT reference, missense
rs836496 -- 6,413,162(+) TCTAA(A/G)GGGAG intron-variant
rs836497 -- 6,414,042(+) GTCTC(A/G)CTCTG intron-variant
rs836498 -- 6,414,068(+) tgcag(C/T)ggcac intron-variant
rs836499 -- 6,414,389(+) ctcac(G/T)gcaac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAGLB Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv7392 OTHER Inversion 18451855
esv1914954 OTHER Inversion 16254605
nsv887428 CNV Loss 21882294
esv2733926 CNV Deletion 23290073
esv2733927 CNV Deletion 23290073

Variation tolerance for DAGLB Gene

Residual Variation Intolerance Score: 61.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.47; 71.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAGLB Gene

HapMap Linkage Disequilibrium report
DAGLB
Human Gene Mutation Database (HGMD)
DAGLB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAGLB Gene

Disorders for DAGLB Gene

MalaCards: The human disease database

(1) MalaCards diseases for DAGLB Gene - From: DISEASES

Disorder Aliases PubMed IDs
hallucinogen dependence
- elite association - COSMIC cancer census association via MalaCards
Search DAGLB in MalaCards View complete list of genes associated with diseases

Relevant External Links for DAGLB

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAGLB
genes like me logo Genes that share disorders with DAGLB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAGLB Gene

Publications for DAGLB Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Discovery and refinement of loci associated with lipid levels. (PMID: 24097068) . … Abecasis G.R. (Nat. Genet. 2013) 3
  4. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3
  5. Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects. (PMID: 16806233) Ma J. … Liew C.C. (Atherosclerosis 2007) 3

Products for DAGLB Gene

Sources for DAGLB Gene

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