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Aliases for DAGLB Gene

Aliases for DAGLB Gene

  • Diacylglycerol Lipase Beta 2 3 5
  • DGL-Beta 3 4
  • KCCR13L 3 4
  • Sn1-Specific Diacylglycerol Lipase Beta 3
  • Diacylglycerol Lipase, Beta 2
  • EC 3.1.1.- 4
  • DAGLBETA 3

External Ids for DAGLB Gene

Summaries for DAGLB Gene

GeneCards Summary for DAGLB Gene

DAGLB (Diacylglycerol Lipase Beta) is a Protein Coding gene. Diseases associated with DAGLB include Hallucinogen Dependence. Among its related pathways are Signaling by GPCR and Effects of PIP2 hydrolysis. GO annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is DAGLA.

UniProtKB/Swiss-Prot for DAGLB Gene

  • Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAGLB Gene

Genomics for DAGLB Gene

Regulatory Elements for DAGLB Gene

Enhancers for DAGLB Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07F006380 1.6 FANTOM5 Ensembl ENCODE 41.4 +99.4 99426 8.7 HDGF ATF1 ARID4B SIN3A FEZF1 SLC30A9 ZNF121 FOS ZNF263 ZHX2 DAGLB ANKRD61 ZNF316 C7orf26 KDELR2 FAM220A USP42 RAC1 CCZ1 ZDHHC4
GH07F006446 1.2 ENCODE 54.3 +35.4 35406 4.4 PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 SLC30A9 DAGLB ZNF316 ENSG00000198580 C7orf26 ENSG00000228010 ANKRD61 KDELR2 USP42 RAC1 ZDHHC4
GH07F006433 1.4 FANTOM5 Ensembl ENCODE 45.3 +47.5 47472 6.2 ELF3 CTCF SAP130 ARID4B MAX RAD21 ZNF316 FOXK2 POLR2A PATZ1 DAGLB RAC1 ZNF815P ZDHHC4 GC07M006436 PIR51766 GC07M006445
GH07F006391 1.3 Ensembl ENCODE 41.1 +90.1 90102 5.8 HDGF ATF1 SIN3A ARID4B GLIS2 GATA2 ZNF143 FOS KLF13 DEK DAGLB RAC1 ZDHHC4 PIR50924 GC07M006427
GH07F006441 1.3 Ensembl ENCODE 37.9 +40.4 40430 3.8 ATF1 CREB3L1 ARID4B SIN3A DMAP1 YY1 GLIS2 GATA2 ZNF143 FOS DAGLB KDELR2 RAC1 ZNF815P ZDHHC4 GC07M006445 PIR51766 GC07M006436
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DAGLB on UCSC Golden Path with GeneCards custom track

Promoters for DAGLB Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001557141 690 2201 ATF1 CREB3L1 ARID4B SIN3A DMAP1 GTF3C2 GLIS2 GATA2 ZNF143 FOS

Genomic Location for DAGLB Gene

Chromosome:
7
Start:
6,409,116 bp from pter
End:
6,484,190 bp from pter
Size:
75,075 bases
Orientation:
Minus strand

Genomic View for DAGLB Gene

Genes around DAGLB on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAGLB Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAGLB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAGLB Gene

Proteins for DAGLB Gene

  • Protein details for DAGLB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCG7-DGLB_HUMAN
    Recommended name:
    Sn1-specific diacylglycerol lipase beta
    Protein Accession:
    Q8NCG7
    Secondary Accessions:
    • A4D2P3
    • B3KV90
    • B4DQU0
    • Q6PIX3
    • Q8N2N2
    • Q8N9S1
    • Q8TED3
    • Q8WXE6

    Protein attributes for DAGLB Gene

    Size:
    672 amino acids
    Molecular mass:
    73732 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85017.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DAGLB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAGLB Gene

Post-translational modifications for DAGLB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAGLB Gene

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DAGLB (DAGLBETA)

No data available for DME Specific Peptides for DAGLB Gene

Domains & Families for DAGLB Gene

Gene Families for DAGLB Gene

Protein Domains for DAGLB Gene

Graphical View of Domain Structure for InterPro Entry

Q8NCG7

UniProtKB/Swiss-Prot:

DGLB_HUMAN :
  • Belongs to the AB hydrolase superfamily. Lipase family.
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with DAGLB: view

Function for DAGLB Gene

Molecular function for DAGLB Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=74.1 uM for diacylglycerol {ECO:0000269 PubMed:14610053}; Vmax=3.45 nmol/min/mg enzyme {ECO:0000269 PubMed:14610053}; pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:14610053};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

Enzyme Numbers (IUBMB) for DAGLB Gene

Gene Ontology (GO) - Molecular Function for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0046872 metal ion binding IEA --
GO:0047372 acylglycerol lipase activity TAS --
genes like me logo Genes that share ontologies with DAGLB: view

Phenotypes for DAGLB Gene

genes like me logo Genes that share phenotypes with DAGLB: view

Animal Models for DAGLB Gene

MGI Knock Outs for DAGLB:

Animal Model Products

  • Taconic Biosciences Mouse Models for DAGLB

miRNA for DAGLB Gene

miRTarBase miRNAs that target DAGLB

Inhibitory RNA Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAGLB Gene

Localization for DAGLB Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAGLB Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAGLB gene
Compartment Confidence
plasma membrane 5
lysosome 5
nucleus 4

Gene Ontology (GO) - Cellular Components for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DAGLB: view

Pathways & Interactions for DAGLB Gene

genes like me logo Genes that share pathways with DAGLB: view

Pathways by source for DAGLB Gene

Interacting Proteins for DAGLB Gene

Gene Ontology (GO) - Biological Process for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0007405 neuroblast proliferation IEA --
GO:0016042 lipid catabolic process IEA --
GO:0019369 arachidonic acid metabolic process IDA 14610053
GO:0022008 neurogenesis IEA --
genes like me logo Genes that share ontologies with DAGLB: view

No data available for SIGNOR curated interactions for DAGLB Gene

Drugs & Compounds for DAGLB Gene

(4) Drugs for DAGLB Gene - From: ApexBio, DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor Lipase inhibitor for obesity treatment, Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 52
RHC80267 Pharma Inhibition, Inhibitor 0
RHC 80267 Pharma diacylglycerol lipase inhibitor, Diacylglycerol lipase inhibitor 0
calcium Nutra 0

(5) Additional Compounds for DAGLB Gene - From: IUPHAR and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
tetrahydrolipstatin
Inhibition, Inhibitor
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)

(1) ApexBio Compounds for DAGLB Gene

Compound Action Cas Number
RHC 80267 diacylglycerol lipase inhibitor 83654-05-1
genes like me logo Genes that share compounds with DAGLB: view

Transcripts for DAGLB Gene

Unigene Clusters for DAGLB Gene

Diacylglycerol lipase, beta:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAGLB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: -
SP6: - - - - - - -
SP7: - - - -
SP8: - -
SP9: - - - - - - - - - -
SP10:
SP11: -
SP12:

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for DAGLB Gene

GeneLoc Exon Structure for
DAGLB
ECgene alternative splicing isoforms for
DAGLB

Expression for DAGLB Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DAGLB Gene

Protein differential expression in normal tissues from HIPED for DAGLB Gene

This gene is overexpressed in NK cells (35.8), Breast (11.3), Peripheral blood mononuclear cells (9.1), and Liver (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DAGLB Gene



Protein tissue co-expression partners for DAGLB Gene

NURSA nuclear receptor signaling pathways regulating expression of DAGLB Gene:

DAGLB

SOURCE GeneReport for Unigene cluster for DAGLB Gene:

Hs.487498
genes like me logo Genes that share expression patterns with DAGLB: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DAGLB Gene

Orthologs for DAGLB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DAGLB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100612262 34
  • 99.57 (n)
dog
(Canis familiaris)
Mammalia DAGLB 34 35
  • 83.68 (n)
cow
(Bos Taurus)
Mammalia DAGLB 34 35
  • 81.27 (n)
mouse
(Mus musculus)
Mammalia Daglb 34 16 35
  • 79.79 (n)
rat
(Rattus norvegicus)
Mammalia Daglb 34
  • 79.06 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 79 (a)
OneToMany
-- 35
  • 62 (a)
OneToMany
-- 35
  • 24 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia DAGLB 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAGLB 34 35
  • 64.96 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
OneToMany
-- 35
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia daglb 34
  • 62.73 (n)
zebrafish
(Danio rerio)
Actinopterygii daglb 34 35
  • 60 (n)
DAGLB (1 of 2) 35
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012171 34
  • 44.09 (n)
worm
(Caenorhabditis elegans)
Secernentea F42G9.6 34 35
  • 44.22 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G05790 34
  • 38.57 (n)
Species where no ortholog for DAGLB was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAGLB Gene

ENSEMBL:
Gene Tree for DAGLB (if available)
TreeFam:
Gene Tree for DAGLB (if available)

Paralogs for DAGLB Gene

Paralogs for DAGLB Gene

(1) SIMAP similar genes for DAGLB Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DAGLB: view

Variants for DAGLB Gene

Sequence variations from dbSNP and Humsavar for DAGLB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs10225406 -- 6,440,492(+) ACATC(G/T)TGTGA intron-variant
rs10226017 -- 6,449,955(+) TTCTA(A/C)ATTCT upstream-variant-2KB
rs10230345 -- 6,421,040(+) gctca(C/T)gcccg intron-variant
rs10237734 -- 6,445,881(+) gaatt(A/G)tatgg intron-variant
rs10239689 -- 6,441,457(+) ctgtc(A/G)tccag intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAGLB Gene

Variant ID Type Subtype PubMed ID
esv1914954 OTHER inversion 16254605
esv2733926 CNV deletion 23290073
esv2733927 CNV deletion 23290073
esv3541121 CNV deletion 23714750
nsv1020236 CNV gain