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Aliases for DAGLB Gene

Aliases for DAGLB Gene

  • Diacylglycerol Lipase, Beta 2 3
  • DGL-Beta 3 4
  • KCCR13L 3 4
  • Sn1-Specific Diacylglycerol Lipase Beta 3
  • EC 3.1.1.- 4
  • DAGLBETA 3

External Ids for DAGLB Gene

Summaries for DAGLB Gene

GeneCards Summary for DAGLB Gene

DAGLB (Diacylglycerol Lipase, Beta) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include triglyceride lipase activity. An important paralog of this gene is DAGLA.

UniProtKB/Swiss-Prot for DAGLB Gene

  • Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAGLB Gene

Genomics for DAGLB Gene

Genomic Location for DAGLB Gene

Start:
6,409,116 bp from pter
End:
6,484,190 bp from pter
Size:
75,075 bases
Orientation:
Minus strand

Genomic View for DAGLB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAGLB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAGLB Gene

Regulatory Elements for DAGLB Gene

Proteins for DAGLB Gene

  • Protein details for DAGLB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NCG7-DGLB_HUMAN
    Recommended name:
    Sn1-specific diacylglycerol lipase beta
    Protein Accession:
    Q8NCG7
    Secondary Accessions:
    • A4D2P3
    • B3KV90
    • B4DQU0
    • Q6PIX3
    • Q8N2N2
    • Q8N9S1
    • Q8TED3
    • Q8WXE6

    Protein attributes for DAGLB Gene

    Size:
    672 amino acids
    Molecular mass:
    73732 Da
    Cofactor:
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB85017.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DAGLB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAGLB Gene

Proteomics data for DAGLB Gene at MOPED

Post-translational modifications for DAGLB Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAGLB Gene

No data available for DME Specific Peptides for DAGLB Gene

Domains for DAGLB Gene

Gene Families for DAGLB Gene

Protein Domains for DAGLB Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q8NCG7

UniProtKB/Swiss-Prot:

DGLB_HUMAN
Family:
  • Belongs to the AB hydrolase superfamily. Lipase family.:
    • Q8NCG7
genes like me logo Genes that share domains with DAGLB: view

Function for DAGLB Gene

Molecular function for DAGLB Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=74.1 uM for diacylglycerol {ECO:0000269 PubMed:14610053}; Vmax=3.45 nmol/min/mg enzyme {ECO:0000269 PubMed:14610053}; pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:14610053};
UniProtKB/Swiss-Prot EnzymeRegulation: Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.
UniProtKB/Swiss-Prot Function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

Enzyme Numbers (IUBMB) for DAGLB Gene

Gene Ontology (GO) - Molecular Function for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016298 lipase activity IBA --
GO:0016787 hydrolase activity --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with DAGLB: view

Phenotypes for DAGLB Gene

MGI mutant phenotypes for DAGLB:
inferred from 2 alleles
GenomeRNAi human phenotypes for DAGLB:
genes like me logo Genes that share phenotypes with DAGLB: view

Animal Models for DAGLB Gene

MGI Knock Outs for DAGLB:

miRNA for DAGLB Gene

miRTarBase miRNAs that target DAGLB

No data available for Transcription Factor Targeting and HOMER Transcription for DAGLB Gene

Localization for DAGLB Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAGLB Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAGLB Gene COMPARTMENTS Subcellular localization image for DAGLB gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0005886 plasma membrane TAS --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DAGLB: view

Pathways for DAGLB Gene

genes like me logo Genes that share pathways with DAGLB: view

Pathways by source for DAGLB Gene

1 GeneGo (Thomson Reuters) pathway for DAGLB Gene
2 Cell Signaling Technology pathways for DAGLB Gene
1 BioSystems pathway for DAGLB Gene

Interacting Proteins for DAGLB Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000297056%0d%0a9606.ENSP00000265052%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000266095%0d%0a
Selected Interacting proteins: Q8NCG7-DGLB_HUMAN ENSP00000297056 for DAGLB Gene via MINT STRING I2D

Gene Ontology (GO) - Biological Process for DAGLB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process --
GO:0007405 neuroblast proliferation IEA --
GO:0007596 blood coagulation TAS --
GO:0016042 lipid catabolic process IEA --
GO:0019369 arachidonic acid metabolic process IDA 14610053
genes like me logo Genes that share ontologies with DAGLB: view

Compounds for DAGLB Gene

(844) HMDB Compounds for DAGLB Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
DG(14:0/14:0/0:0)
  • DAG(14:0/14:0)
Not Available
DG(14:0/14:1(9Z)/0:0)
  • DAG(14:0/14:1)
Not Available
DG(14:0/15:0/0:0)
  • Diacylglycerol(29:0)
Not Available
DG(14:0/16:0/0:0)
  • DAG(30:0)
Not Available

(2) IUPHAR Ligand for DAGLB Gene

Ligand Type Action Affinity Pubmed IDs
tetrahydrolipstatin Inhibitor Inhibition 7.2
RHC80267 Inhibitor Inhibition
genes like me logo Genes that share compounds with DAGLB: view

Transcripts for DAGLB Gene

Unigene Clusters for DAGLB Gene

Diacylglycerol lipase, beta:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DAGLB Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c ^ 5 ^ 6a · 6b ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13a · 13b ^ 14 ^ 15a · 15b ^
SP1: - - - - - -
SP2: - - - - - - - - - - - -
SP3: - - - - - - - - - - -
SP4: - -
SP5: -
SP6: - - - - - - -
SP7: - - - -
SP8: - -
SP9: - - - - - - - - - -
SP10:
SP11: -
SP12:

ExUns: 16 ^ 17
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:

Relevant External Links for DAGLB Gene

GeneLoc Exon Structure for
DAGLB
ECgene alternative splicing isoforms for
DAGLB

Expression for DAGLB Gene

mRNA expression in normal human tissues for DAGLB Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DAGLB Gene

SOURCE GeneReport for Unigene cluster for DAGLB Gene Hs.487498

genes like me logo Genes that share expressions with DAGLB: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DAGLB Gene

Orthologs for DAGLB Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DAGLB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia LOC100612262 35
  • 99.57 (n)
  • 100 (a)
cow
(Bos Taurus)
Mammalia DAGLB 35
  • 81.27 (n)
  • 83.56 (a)
DAGLB 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAGLB 35
  • 83.68 (n)
  • 85.97 (a)
DAGLB 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Daglb 35
  • 79.79 (n)
  • 79.34 (a)
Daglb 16
Daglb 36
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DAGLB 36
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 24 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Daglb 35
  • 79.06 (n)
  • 78.11 (a)
chicken
(Gallus gallus)
Aves DAGLB 35
  • 64.96 (n)
  • 61.54 (a)
DAGLB 36
  • 62 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
-- 36
  • 56 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia daglb 35
  • 62.73 (n)
  • 60.97 (a)
zebrafish
(Danio rerio)
Actinopterygii daglb 35
  • 60 (n)
  • 58.86 (a)
daglb 36
  • 58 (a)
OneToMany
DAGLB (1 of 2) 36
  • 48 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012171 35
  • 44.09 (n)
  • 33.07 (a)
worm
(Caenorhabditis elegans)
Secernentea F42G9.6 35
  • 44.22 (n)
  • 35.33 (a)
F42G9.6 36
  • 28 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G05790 35
  • 38.57 (n)
  • 30.3 (a)
Species with no ortholog for DAGLB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAGLB Gene

ENSEMBL:
Gene Tree for DAGLB (if available)
TreeFam:
Gene Tree for DAGLB (if available)

Paralogs for DAGLB Gene

Paralogs for DAGLB Gene

Selected SIMAP similar genes for DAGLB Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with DAGLB: view

Variants for DAGLB Gene

Sequence variations from dbSNP and Humsavar for DAGLB Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs702485 -- 6,409,641(+) TGCTC(A/G)CTACT utr-variant-3-prime
rs702486 -- 6,417,345(+) CTGGA(A/G)CACAT intron-variant
rs836496 -- 6,413,162(+) TCTAA(A/G)GGGAG intron-variant
rs836497 -- 6,414,042(+) GTCTC(A/G)CTCTG intron-variant
rs836498 -- 6,414,068(+) tgcag(C/T)ggcac intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAGLB Gene

Variant ID Type Subtype PubMed ID
nsv436904 CNV Insertion 17901297
nsv7392 OTHER Inversion 18451855
esv1914954 OTHER Inversion 16254605
nsv887428 CNV Loss 21882294
esv2733926 CNV Deletion 23290073
esv2733927 CNV Deletion 23290073

Relevant External Links for DAGLB Gene

HapMap Linkage Disequilibrium report
DAGLB
Human Gene Mutation Database (HGMD)
DAGLB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAGLB Gene

Disorders for DAGLB Gene

No disorders were found for DAGLB Gene.

No data available for UniProtKB/Swiss-Prot for DAGLB Gene

Publications for DAGLB Gene

  1. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  2. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 4
  3. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. (PMID: 14610053) Bisogno T. … Doherty P. (J. Cell Biol. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for DAGLB Gene

Sources for DAGLB Gene

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