Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DAGLA Gene

Aliases for DAGLA Gene

  • Diacylglycerol Lipase Alpha 2 3
  • Neural Stem Cell-Derived Dendrite Regulator 2 3 4
  • Diacylglycerol Lipase, Alpha 2 5
  • DGL-Alpha 3 4
  • C11orf11 3 4
  • NSDDR 3 4
  • Chromosome 11 Open Reading Frame 11 2
  • EC 3.1.1.- 4
  • KIAA0659 4

External Ids for DAGLA Gene

Previous HGNC Symbols for DAGLA Gene

  • C11orf11

Previous GeneCards Identifiers for DAGLA Gene

  • GC11P061205
  • GC11P061447
  • GC11P057776

Summaries for DAGLA Gene

Entrez Gene Summary for DAGLA Gene

  • This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the endocannabinoid 2-arachidonoyl-glycerol.[provided by RefSeq, Nov 2010]

GeneCards Summary for DAGLA Gene

DAGLA (Diacylglycerol Lipase Alpha) is a Protein Coding gene. Diseases associated with DAGLA include Spinocerebellar Ataxia 20 and Spasmodic Dysphonia. Among its related pathways are Interleukin-3, 5 and GM-CSF signaling and Signaling by GPCR. GO annotations related to this gene include hydrolase activity and lipase activity. An important paralog of this gene is DAGLB.

UniProtKB/Swiss-Prot for DAGLA Gene

  • Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAGLA Gene

Genomics for DAGLA Gene

Regulatory Elements for DAGLA Gene

Enhancers for DAGLA Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DAGLA on UCSC Golden Path with GeneCards custom track

Promoters for DAGLA Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DAGLA on UCSC Golden Path with GeneCards custom track

Genomic Location for DAGLA Gene

61,680,433 bp from pter
61,747,002 bp from pter
66,570 bases
Plus strand

Genomic View for DAGLA Gene

Genes around DAGLA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAGLA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAGLA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAGLA Gene

Proteins for DAGLA Gene

  • Protein details for DAGLA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Sn1-specific diacylglycerol lipase alpha
    Protein Accession:
    Secondary Accessions:
    • A7E233
    • Q6WQJ0

    Protein attributes for DAGLA Gene

    1042 amino acids
    Molecular mass:
    114952 Da
    Name=Ca(2+); Xref=ChEBI:CHEBI:29108;
    Quaternary structure:
    No Data Available
    • Sequence=BAA31634.2; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for DAGLA Gene

Proteomics data for DAGLA Gene at MOPED

Post-translational modifications for DAGLA Gene

  • Glycosylation at Asn 133
  • Modification sites at PhosphoSitePlus

Other Protein References for DAGLA Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for DAGLA (NSDDR)

No data available for DME Specific Peptides for DAGLA Gene

Domains & Families for DAGLA Gene

Gene Families for DAGLA Gene

Protein Domains for DAGLA Gene


Suggested Antigen Peptide Sequences for DAGLA Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the AB hydrolase superfamily. Lipase family.
  • Belongs to the AB hydrolase superfamily. Lipase family.
genes like me logo Genes that share domains with DAGLA: view

Function for DAGLA Gene

Molecular function for DAGLA Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=154.7 uM for diacylglycerol {ECO:0000269 PubMed:14610053}; Vmax=33.3 nmol/min/mg enzyme {ECO:0000269 PubMed:14610053}; pH dependence: Optimum pH is 7.0. {ECO:0000269 PubMed:14610053};
UniProtKB/Swiss-Prot EnzymeRegulation:
Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by RHC80267, a drug that blocks 2-AG formation.
UniProtKB/Swiss-Prot Function:
Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling at mature synapses.

Enzyme Numbers (IUBMB) for DAGLA Gene

genes like me logo Genes that share phenotypes with DAGLA: view

Animal Models for DAGLA Gene

MGI Knock Outs for DAGLA:

Animal Model Products

miRNA for DAGLA Gene

miRTarBase miRNAs that target DAGLA

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAGLA Gene

Localization for DAGLA Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAGLA Gene

Cell membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for DAGLA Gene COMPARTMENTS Subcellular localization image for DAGLA gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for DAGLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043196 varicosity IEA --
genes like me logo Genes that share ontologies with DAGLA: view

Pathways & Interactions for DAGLA Gene

genes like me logo Genes that share pathways with DAGLA: view

Pathways by source for DAGLA Gene

Interacting Proteins for DAGLA Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000257215 Q9Y4D2-DGLA_HUMAN for DAGLA Gene via STRING I2D

Gene Ontology (GO) - Biological Process for DAGLA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0022008 neurogenesis IEA --
GO:0030168 platelet activation TAS --
GO:0046340 diacylglycerol catabolic process IDA 14610053
genes like me logo Genes that share ontologies with DAGLA: view

No data available for SIGNOR curated interactions for DAGLA Gene

Drugs & Compounds for DAGLA Gene

(3) Drugs for DAGLA Gene - From: DGIdb, IUPHAR, and HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Orlistat Approved, Investigational Pharma inhibitor Pancreatic, gastric and carboxylester lipase inhibitor; antiobesity and antihypercholesterolemic activity 52
RHC80267 Pharma Inhibition, Inhibitor 0
calcium Nutra 0

(5) Additional Compounds for DAGLA Gene - From: IUPHAR and HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Inhibition, Inhibitor
Diglycerides Group A
  • 1,2-Dimyristoyl-rac-glycerol
  • DAG(14:0/14:0)
  • DAG(28:0)
  • DG(14:0/14:0)
  • DG(28:0)
Diglycerides Group B
  • 1-Palmitoleoyl-2-arachidonyl-sn-glycerol
  • DAG(16:1/20:0)
  • DAG(16:1n7/20:0)
  • DAG(16:1w7/20:0)
  • DAG(36:1)
Diglycerides Group C
  • 1-Myristoyl-3-stearoyl-sn-glycerol
  • 1-Tetradecanoyl-3-octadecanoyl-sn-glycerol
  • DAG(14:0/0:0/18:0)
  • DAG(32:0)
  • DG(32:0)
Diglycerides Group D
  • 1,2-Didocosahexaenoyl-rac-glycerol
  • DAG(22:6/22:6)
  • DAG(22:6n3/22:6n3)
  • DAG(22:6w3/22:6w3)
  • DAG(44:12)
genes like me logo Genes that share compounds with DAGLA: view

Transcripts for DAGLA Gene

Unigene Clusters for DAGLA Gene

Diacylglycerol lipase, alpha:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DAGLA Gene

No ASD Table

Relevant External Links for DAGLA Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for DAGLA Gene

mRNA expression in normal human tissues for DAGLA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAGLA Gene

This gene is overexpressed in Brain - Cortex (x5.3) and Brain - Frontal Cortex (BA9) (x4.3).

Protein differential expression in normal tissues from HIPED for DAGLA Gene

This gene is overexpressed in Adipocyte (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for DAGLA Gene

SOURCE GeneReport for Unigene cluster for DAGLA Gene Hs.241564

mRNA Expression by UniProt/SwissProt for DAGLA Gene

Tissue specificity: Highly expressed in brain and pancreas.
genes like me logo Genes that share expression patterns with DAGLA: view

Protein tissue co-expression partners for DAGLA Gene

- Elite partner

Primer Products

Orthologs for DAGLA Gene

This gene was present in the common ancestor of animals.

Orthologs for DAGLA Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia DAGLA 35
  • 91.89 (n)
  • 97.69 (a)
  • 97 (a)
(Canis familiaris)
Mammalia DAGLA 35
  • 91.71 (n)
  • 97.55 (a)
  • 94 (a)
(Mus musculus)
Mammalia Dagla 35
  • 89.41 (n)
  • 97.41 (a)
Dagla 16
Dagla 36
  • 97 (a)
(Pan troglodytes)
Mammalia DAGLA 35
  • 98.95 (n)
  • 99.12 (a)
  • 99 (a)
(Rattus norvegicus)
Mammalia Dagla 35
  • 89.35 (n)
  • 97.41 (a)
(Ornithorhynchus anatinus)
Mammalia DAGLA 36
  • 91 (a)
(Gallus gallus)
Aves DAGLA 35
  • 79.79 (n)
  • 89.31 (a)
  • 89 (a)
(Anolis carolinensis)
Reptilia DAGLA 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dagla 35
  • 75.12 (n)
  • 85.33 (a)
(Danio rerio)
Actinopterygii dagla 35
  • 67.26 (n)
  • 71.7 (a)
dagla 36
  • 63 (a)
fruit fly
(Drosophila melanogaster)
Insecta inaE 36
  • 22 (a)
Species with no ortholog for DAGLA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DAGLA Gene

Gene Tree for DAGLA (if available)
Gene Tree for DAGLA (if available)

Paralogs for DAGLA Gene

Paralogs for DAGLA Gene

(1) SIMAP similar genes for DAGLA Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DAGLA: view

Variants for DAGLA Gene

Sequence variations from dbSNP and Humsavar for DAGLA Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs3741252 - 61,744,026(+) CGGGC(C/T)GGCCT reference, missense
rs35056845 - 61,743,564(+) GGAGG(G/T)CTTCT reference, missense
rs34956386 - 61,744,195(+) AGTGA(C/G)TACGC reference, missense
rs519678 -- 61,715,395(-) CCCCC(A/G)CGAGT intron-variant
rs533292 -- 61,711,058(-) AGGCA(G/T)CGACT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAGLA Gene

Variant ID Type Subtype PubMed ID
nsv832179 CNV Loss 17160897
dgv1152n71 CNV Loss 21882294
esv1003572 CNV Deletion 20482838
nsv528697 CNV Loss 19592680
nsv897607 CNV Loss 21882294
dgv1153n71 CNV Loss 21882294
nsv897611 CNV Loss 21882294
nsv897612 CNV Loss 21882294

Variation tolerance for DAGLA Gene

Residual Variation Intolerance Score: 2.26% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.58; 56.12% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for DAGLA Gene

Disorders for DAGLA Gene

MalaCards: The human disease database

(2) MalaCards diseases for DAGLA Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
spinocerebellar ataxia 20
  • spinocerebellar ataxia type 20
spasmodic dysphonia
  • laryngeal dystonia
- elite association - COSMIC cancer census association via MalaCards
Search DAGLA in MalaCards View complete list of genes associated with diseases


  • Spinocerebellar ataxia 20 (SCA20) [MIM:608687]: Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement of the brainstem and spinal cord. SCA20 is an autosomal dominant, adult-onset form characterized by dysarthria due to spasmodic dysphonia followed by slowly progressive ataxia. {ECO:0000269 PubMed:18801880}. Note=The disease may be caused by mutations affecting the gene represented in this entry. A copy number variation consisting of a 260-kb duplication at chromosome 11q12.2-12.3 is responsible for SCA20. The critical gene within the duplicated segment may be DAGLA.

Relevant External Links for DAGLA

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with DAGLA: view

No data available for Genatlas for DAGLA Gene

Publications for DAGLA Gene

  1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Nuclear phospholipase C-I^1 and diacylglycerol LIPASE-I+ in brain cortical neurons. (PMID: 24076015) GarcA-a del CaA+o G. … SallAcs J. (Adv Biol Regul 2014) 3
  4. Influence of dietary fat intake on the endocannabinoid system in lean and obese subjects. (PMID: 24616451) Engeli S. … Jordan J. (Obesity (Silver Spring) 2014) 3
  5. Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium. (PMID: 24823311) Guan W. … Steffen L.M. (Circ Cardiovasc Genet 2014) 3

Products for DAGLA Gene

Sources for DAGLA Gene