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DAGLA Gene

protein-coding   GIFtS: 57
GCID: GC11P061447

Diacylglycerol Lipase, Alpha

(Previous name: chromosome 11 open reading frame 11)
(Previous symbol: C11orf11)
  See DAGLA-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Diacylglycerol Lipase, Alpha1 2     Chromosome 11 Open Reading Frame 111
C11orf111 2 3     DAGL(ALPHA)2
Neural Stem Cell-Derived Dendrite Regulator1 2 3     DAGLALPHA2
DGL-alpha2 3     Sn1-Specific Diacylglycerol Lipase Alpha2
NSDDR2 3     EC 3.1.1.-3
KIAA06593 5     

External Ids:    HGNC: 11651   Entrez Gene: 7472   Ensembl: ENSG000001347807   OMIM: 6140155   UniProtKB: Q9Y4D23   

Export aliases for DAGLA gene to outside databases

Previous GC identifers: GC11P061205 GC11P057776


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DAGLA Gene:
This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the
endocannabinoid 2-arachidonoyl-glycerol.(provided by RefSeq, Nov 2010)

GeneCards Summary for DAGLA Gene:
DAGLA (diacylglycerol lipase, alpha) is a protein-coding gene. Diseases associated with DAGLA include spinocerebellar ataxia type 20. GO annotations related to this gene include triglyceride lipase activity. An important paralog of this gene is DAGLB.

UniProtKB/Swiss-Prot: DGLA_HUMAN, Q9Y4D2
Function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant
endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling
at mature synapses




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NT_167190.2  NC_018922.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAGLA gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   AP-2gamma   E2F   E2F-1   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAGLA promoter sequence
   Search Chromatin IP Primers for DAGLA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAGLA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.3

DAGLA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAGLA gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P061447:  view genomic region     (about GC identifiers)

Start:
61,447,905 bp from pter      End:
61,514,474 bp from pter
Size:
66,570 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DGLA_HUMAN, Q9Y4D2 (See protein sequence)
Recommended Name: Sn1-specific diacylglycerol lipase alpha  
Size: 1042 amino acids; 114952 Da
Cofactor: Calcium
Sequence caution: Sequence=BAA31634.2; Type=Erroneous initiation;
Secondary accessions: A7E233 Q6WQJ0

Explore the universe of human proteins at neXtProt for DAGLA: NX_Q9Y4D2

Explore proteomics data for DAGLA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn133
  • Modification sites at PhosphoSitePlus

  • See DAGLA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006124.1  
    ENSEMBL proteins: 
     ENSP00000257215   ENSP00000440264  
    Reactome Protein details: Q9Y4D2

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    IUPHAR Guide to PHARMACOLOGY protein family classification: Diacylglycerol lipase alpha
    Endocannabinoid turnover

    1 InterPro protein domain:
     IPR002921 Lipase_3

    Graphical View of Domain Structure for InterPro Entry Q9Y4D2

    ProtoNet protein and cluster: Q9Y4D2

    UniProtKB/Swiss-Prot: DGLA_HUMAN, Q9Y4D2
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family


    Find genes that share domains with DAGLA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGLA_HUMAN, Q9Y4D2
    Function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant
    endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling
    at mature synapses
    Enzyme regulation: Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by
    RHC80267, a drug that blocks 2-AG formation
    Biophysicochemical properties: Kinetic parameters: KM=154.7 uM for diacylglycerol; Vmax=33.3 nmol/min/mg enzyme;
    pH dependence: Optimum pH is 7.0;

         Enzyme Number (IUBMB): EC 3.1.1.-1

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004806triglyceride lipase activity IEA--
    GO:0046872metal ion binding IEA--
         
    Find genes that share ontologies with DAGLA           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DAGLA:
     Increased cell number in G2M,   Upregulation of Wnt/beta-caten 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dagla):
     cellular  growth/size/body  homeostasis/metabolism  nervous system 

    Find genes that share phenotypes with DAGLA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Daglatm1.1Kano for DAGLA

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DAGLA
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    hsa-mir-335-5p (MIRT018137)

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    Selected qRT-PCR Assays for microRNAs that regulate DAGLA (see all 72):
    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-300 hsa-miR-1914* hsa-miR-485-3p hsa-miR-30d hsa-miR-4267 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidDAGLA 3' UTR sequence
    Inhib. RNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DGLA_HUMAN, Q9Y4D2: Cell membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    extracellular2

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with DAGLA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAGLA About   (see all 7)  
    See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    2Gastrin-CREB signalling pathway via PKC and MAPK
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Hemostasis
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Effects of PIP2 hydrolysis
    Effects of PIP2 hydrolysis
    Arachidonate production from DAG0.00
    5Development Dopamine D2 receptor transactivation of EGFR
    Development Alpha 2 adrenergic receptor activation of ERK0.66


    Find genes that share SuperPaths with DAGLA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for DAGLA
        Development Alpha-2 adrenergic receptor activation of ERK

    1 BioSystems Pathway for DAGLA
        N-cadherin signaling events

    1 Reactome Pathway for DAGLA
        Arachidonate production from DAG


    1 Kegg Pathway  (Kegg details for DAGLA):
        Retrograde endocannabinoid signaling

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DAGLA
    Interactions:

        Search GeneGlobe Interaction Network for DAGLA

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for DAGLA (Q9Y4D23 ENSP000002572154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIPC1O149083I2D: score=1 
    MGLLENSP000002650524STRING: ENSP00000265052
    GATA4ENSP000003344584STRING: ENSP00000334458
    GATA5ENSP000002529974STRING: ENSP00000252997
    GATA6ENSP000002692164STRING: ENSP00000269216
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0007405neuroblast proliferation IEA--
    GO:0007596blood coagulation TAS--
    GO:0008219cell death IEA--
    GO:0019369arachidonic acid metabolic process IDA14610053

    Find genes that share ontologies with DAGLA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
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    Browse Tocris compounds for DAGLA (DGLA)

    Selected HMDB Compounds for DAGLA (see all 844)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----

    2 IUPHAR Ligands for DAGLA (Diacylglycerol lipase alpha)    About this table
    LigandTypeActionAffinityPubmed IDs
    tetrahydrolipstatin
    InhibitorInhibition7.214610053
    RHC80267
    InhibitorInhibition7.2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DAGLA gene: 
    NM_006133.2  

    Unigene Cluster for DAGLA:

    Diacylglycerol lipase, alpha
    Hs.241564  [show with all ESTs]
    Unigene Representative Sequence: BC150195
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257215(uc001nsa.3) ENST00000540717
    miRNA
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    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-300 hsa-miR-1914* hsa-miR-485-3p hsa-miR-30d hsa-miR-4267 hsa-miR-30a
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    Additional mRNA sequence: 

    AB014559.2 AY275377.1 BC150176.1 BC150195.1 BC152453.1 

    2 DOTS entries:

    DT.105877  DT.92419455 

    Selected AceView cDNA sequences (see all 40):

    NM_006133 BM068819 BI964010 AI216160 CK904653 BM126486 T16247 AY275377 
    CR596071 AI140579 BI964152 BE907563 BX452062 BM054786 BE531065 BE735837 
    BI918354 BE615414 BM763121 BG748842 BI752614 BG764500 BX645187 BE531188 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAGLA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTCTCTTA
    DAGLA Expression
    About this image


    DAGLA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Blood (Hematopoietic System)
             Monocytes Peripheral Blood
     
     Pancreas (Endocrine System)
    DAGLA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAGLA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.241564

    UniProtKB/Swiss-Prot: DGLA_HUMAN, Q9Y4D2
    Tissue specificity: Highly expressed in brain and pancreas

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DAGLA gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dagla1 , 5 diacylglycerol lipase, alpha1, 5 89.41(n)1
    97.41(a)1
      19 (6.55 cM)5
    2690601  NM_198114.21  NP_932782.21 
     102452655 
    chicken
    (Gallus gallus)
    Aves DAGLA1 diacylglycerol lipase, alpha 79.79(n)
    89.31(a)
      426017  XM_423696.4  XP_423696.3 
    lizard
    (Anolis carolinensis)
    Reptilia DAGLA6
    diacylglycerol lipase, alpha
    87(a)
    1 ↔ 1
    GL343235.1(1578185-1640139)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ640573.12   -- 73.13(n)    BJ640573.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dagla1 diacylglycerol lipase, alpha 67.26(n)
    71.7(a)
      569398  XM_692781.5  XP_697873.5 
    fruit fly
    (Drosophila melanogaster)
    Insecta inaE6
    inactivation no afterpotential E
    22(a)
    1 ↔ 1
    X(13677782-13705526)


    ENSEMBL Gene Tree for DAGLA (if available)
    TreeFam Gene Tree for DAGLA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAGLA gene
    DAGLB2  
    1 SIMAP similar gene for DAGLA using alignment to 2 protein entries:     DGLA_HUMAN (see all proteins):
    DAGLB

    Find genes that share paralogs with DAGLA           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAGLA (see all 1233)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881809431,2
    --61445945(+) CTCTGC/TCTCCC 1 -- us2k10--------
    rs1155313611,2
    F--61446038(+) CTTTGG/ATAGAG 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1807083111,2
    C--61446153(+) CCCCTA/GGCCGA 1 -- us2k10--------
    rs1850470341,2
    --61446161(+) CGACAA/GTCTTT 1 -- us2k10--------
    rs1902960531,2
    --61446217(+) TCAACG/TGGGAA 1 -- us2k10--------
    rs1452878721,2
    --61446283(+) TGACCA/GTGGCC 1 -- us2k10--------
    rs49633041,2
    C,F,A--61446352(+) ATCCAG/ATCTGG 1 -- us2k110Minor allele frequency- A:0.45NA WA CSA EA 372
    rs79315631,2
    C,F,A,H--61446425(+) AGTTGT/GCCCTT 1 -- us2k124Minor allele frequency- G:0.47NS EA NA WA 2762
    rs1491619961,2
    --61446483(+) TCCTCC/TTTGAA 1 -- us2k10--------
    rs79423871,2
    C,F--61446501(+) AGGTGC/ACCCAC 1 -- us2k11Minor allele frequency- A:0.11WA 118

    HapMap Linkage Disequilibrium report for DAGLA (61447905 - 61514474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DAGLA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1003572CNV Deletion20482838
    nsv528697CNV Loss19592680
    nsv897611CNV Loss21882294
    nsv897612CNV Loss21882294
    nsv832179CNV Loss17160897
    dgv1153n71CNV Loss21882294
    dgv1152n71CNV Loss21882294
    nsv897607CNV Loss21882294

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for DAGLA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 614015    OMIM disorders: --

    UniProtKB/Swiss-Prot: DGLA_HUMAN, Q9Y4D2
  • Spinocerebellar ataxia 20 (SCA20) [MIM:608687]: Spinocerebellar ataxia is a clinically and genetically
    heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor
    coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement
    of the brainstem and spinal cord. SCA20 is an autosomal dominant, adult-onset form characterized by dysarthria
    due to spasmodic dysphonia followed by slowly progressive ataxia. Note=The disease may be caused by mutations
    affecting the gene represented in this entry. A copy number variation consisting of a 260-kb duplication at
    chromosome 11q12.2-12.3 is responsible for SCA20. The critical gene within the duplicated segment may be DAGLA

  • 1 disease for DAGLA:    
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    spinocerebellar ataxia type 20


    Find genes that share disorders with DAGLA           About GenesLikeMe

    Genetic Association Database (GAD): DAGLA

    Export disorders for DAGLA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAGLA gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with DAGLA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (DNA Res. 1998)
    2. Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium. (PubMed id 21829377)1, 4 Lemaitre R.N....Steffen L.M. (PLoS Genet. 2011)
    3. A duplication at chromosome 11q12.2-11q12.3 is associated with spinocerebellar ataxia type 20. (PubMed id 18801880)1, 2 Knight M.A.... Singleton A.B. (Hum. Mol. Genet. 2008)
    4. Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. (PubMed id 16051747)1, 2 Jung K.-M.... Piomelli D. (Mol. Pharmacol. 2005)
    5. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. (PubMed id 14610053)1, 2 Bisogno T.... Doherty P. (J. Cell Biol. 2003)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (DNA Res. 2002)
    7. Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex. (PubMed id 22827915)1 Long L.E....Weickert C.S. (BMC Neurosci 2012)
    8. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (Hum. Genet. 2012)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725)6 Kurz M....Kramer W. (Proteins 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 747 HGNC: 1165 AceView: C11orf11 Ensembl:ENSG00000134780 euGenes: HUgn747
    ECgene: DAGLA Kegg: 747 H-InvDB: DAGLA

    (According to HUGE)
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    HUGE: KIAA0659

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DAGLA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DAGLA gene:
    Search GeneIP for patents involving DAGLA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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