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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAGLA Gene

protein-coding   GIFtS: 55
GCID: GC11P061447

Diacylglycerol Lipase, Alpha

(Previous name: chromosome 11 open reading frame 11)
(Previous symbol: C11orf11)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Diacylglycerol Lipase, Alpha1 2     DAGL(ALPHA)2
C11orf111 2 3     DAGLALPHA2
Neural Stem Cell-Derived Dendrite Regulator1 2 3     Sn1-Specific Diacylglycerol Lipase Alpha2
DGL-alpha2 3     EC 3.1.1.-3
NSDDR2 3     KIAA06593
Chromosome 11 Open Reading Frame 111     

External Ids:    HGNC: 11651   Entrez Gene: 7472   Ensembl: ENSG000001347807   OMIM: 6140155   UniProtKB: Q9Y4D23   

Export aliases for DAGLA gene to outside databases

Previous GC identifers: GC11P061205 GC11P057776


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DAGLA Gene:
This gene encodes a diacylglycerol lipase. The encoded enzyme is involved in the biosynthesis of the
endocannabinoid 2-arachidonoyl-glycerol.(provided by RefSeq, Nov 2010)

GeneCards Summary for DAGLA Gene: 
DAGLA (diacylglycerol lipase, alpha) is a protein-coding gene. Diseases associated with DAGLA include spinocerebellar ataxia type 20, and spasmodic dysphonia, and among its related super-pathways are Signaling by GPCR and Gastrin-CREB signalling pathway via PKC and MAPK. GO annotations related to this gene include triglyceride lipase activity and metal ion binding. An important paralog of this gene is DAGLB.

UniProtKB/Swiss-Prot: DGLA_HUMAN, Q9Y4D2
Function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant
endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling
at mature synapses




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000011.9  NT_167190.1  NC_018922.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAGLA gene promoter:
         E2F-4   E2F-3a   E2F-5   E2F-2   AP-2gamma   E2F   E2F-1   AP-2beta   AP-2alpha   AP-2alphaA   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAGLA promoter sequence
   Search SABiosciences Chromatin IP Primers for DAGLA

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAGLA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q12.2   Ensembl cytogenetic band:  11q12.2   HGNC cytogenetic band: 11q12.3

DAGLA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAGLA gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11P061447:  view genomic region     (about GC identifiers)

Start:
61,447,905 bp from pter      End:
61,514,474 bp from pter
Size:
66,570 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DGLA_HUMAN, Q9Y4D2 (See protein sequence)
Recommended Name: Sn1-specific diacylglycerol lipase alpha  
Size: 1042 amino acids; 114952 Da
Cofactor: Calcium
Subcellular location: Cell membrane; Multi-pass membrane protein
Sequence caution: Sequence=BAA31634.2; Type=Erroneous initiation;
Secondary accessions: A7E233 Q6WQJ0

Explore the universe of human proteins at neXtProt for DAGLA: NX_Q9Y4D2

Explore proteomics data for DAGLA at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4D2

  • DAGLA Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DAGLA Protein Expression
    REFSEQ proteins: NP_006124.1  
    ENSEMBL proteins: 
     ENSP00000257215   ENSP00000440264  
    Reactome Protein details: Q9Y4D2
    Human Recombinant Protein Products for DAGLA: 
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    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane TAS--
    GO:0016021integral to membrane IEA--

    DAGLA for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    IUPHAR Guide to PHARMACOLOGY protein family classification: Diacylglycerol lipase &alpha 
    Endocannabinoid turnover

    1 InterPro protein domain:
     IPR002921 Lipase_3

    Graphical View of Domain Structure for InterPro Entry Q9Y4D2

    ProtoNet protein and cluster: Q9Y4D2

    UniProtKB/Swiss-Prot: DGLA_HUMAN, Q9Y4D2
    Similarity: Belongs to the AB hydrolase superfamily. Lipase family


    DAGLA for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DGLA_HUMAN, Q9Y4D2
    Function: Catalyzes the hydrolysis of diacylglycerol (DAG) to 2-arachidonoyl-glycerol (2-AG), the most abundant
    endocannabinoid in tissues. Required for axonal growth during development and for retrograde synaptic signaling
    at mature synapses
    Enzyme regulation: Inhibited by p-hydroxy-mercuri-benzoate and HgCl(2), but not to PMSF. Also inhibited by
    RHC80267, a drug that blocks 2-AG formation
    Biophysicochemical properties: Kinetic parameters: KM=154.7 uM for diacylglycerol; Vmax=33.3 nmol/min/mg enzyme;
    pH dependence: Optimum pH is 7.0;

         Enzyme Number (IUBMB): EC 3.1.1.-1

         Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004806triglyceride lipase activity IEA--
    GO:0046872metal ion binding IEA--
         
    DAGLA for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DAGLA:
     Increased cell number in G2M,   Upregulation of Wnt/beta-caten 

         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Dagla):
     cellular  growth/size  homeostasis/metabolism  nervous system 

    DAGLA for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Daglatm1.1Kano for DAGLA

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DAGLA 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DAGLA

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    miRNA
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    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-300 hsa-miR-1914* hsa-miR-485-3p hsa-miR-30d hsa-miR-4267 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidDAGLA 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAGLA


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DAGLA About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.55
    GPCR downstream signaling0.90
    2G alpha (q) signalling events
    Gastrin-CREB signalling pathway via PKC and MAPK0.90
    G alpha (q) signalling events0.90
    3Platelet activation, signaling and aggregation
    Hemostasis0.43
    Platelet activation, signaling and aggregation0.43
    4Development Dopamine D2 receptor transactivation of EGFR
    Development Alpha-2 adrenergic receptor activation of ERK0.66
    5Circadian entrainment
    Retrograde endocannabinoid signaling0.51

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for DAGLA
        Development Alpha-2 adrenergic receptor activation of ERK


    1 GeneGo (Thomson Reuters) Pathway for DAGLA
        Development Alpha-2 adrenergic receptor activation of ERK

    1 BioSystems Pathway for DAGLA
        N-cadherin signaling events

    5/9        Reactome Pathways for DAGLA (see all 9)
        GPCR downstream signaling
    Hemostasis
    Gastrin-CREB signalling pathway via PKC and MAPK
    Signaling by GPCR
    Arachidonate production from DAG


    1         Kegg Pathway  (Kegg details for DAGLA):
        Retrograde endocannabinoid signaling


    DAGLA for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DAGLA

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for DAGLA (Q9Y4D23 ENSP000002572154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    GIPC1O149083I2D: score=1 
    MGLLENSP000002650524STRING: ENSP00000265052
    About this table

    Gene Ontology (GO): 5/10 biological process terms (GO ID links to tree view) (see all 10):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process ----
    GO:0007405neuroblast proliferation IEA--
    GO:0007596blood coagulation TAS--
    GO:0008219cell death IEA--
    GO:0016042lipid catabolic process IEA--

    DAGLA for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    EMD Millipore small molecules for DAGLA:
    Small Molecule - inhibitor
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DAGLA (DGLA)

    10/844 HMDB Compounds for DAGLA (see all 844)    About this table
    CompoundSynonyms CAS #PubMed Ids
    DG(16:0e/18:0/0:0)2-Octadecanoyl-1-hexadecyl-sn-glycerol (see all 2)--12486725
    CalciumCa (see all 2)7440-70-2--
    DG(14:0/14:0/0:0)DAG(14:0/14:0) (see all 9)----
    DG(14:0/14:1(9Z)/0:0)DAG(14:0/14:1) (see all 15)----
    DG(14:0/15:0/0:0)Diacylglycerol(29:0) (see all 9)----
    DG(14:0/16:0/0:0)DAG(30:0) (see all 9)----
    DG(14:0/16:1(9Z)/0:0)DG(30:1) (see all 15)----
    DG(14:0/18:0/0:0)DG(14:0/18:0) (see all 9)----
    DG(14:0/18:1(11Z)/0:0)Diacylglycerol (see all 15)----
    DG(14:0/18:1(9Z)/0:0)1-myristoyl-2-oleoyl-sn-glycerol (see all 15)----

    2 IUPHAR Ligands for DAGLA (Diacylglycerol lipase &alpha)    About this table 
    LigandTypeActionAffinityPubmed IDs
    tetrahydrolipstatin
    Inhibitor7.214610053
    RHC80267
    InhibitorInhibition7.2--

    Search CenterWatch for drugs/clinical trials and news about DAGLA / DGLA

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DAGLA gene: 
    NM_006133.2  

    Unigene Cluster for DAGLA:

    Diacylglycerol lipase, alpha
    Hs.241564  [show with all ESTs]
    Unigene Representative Sequence: BC150195
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000257215(uc001nsa.3) ENST00000540717
    miRNA
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    8/72 QIAGEN miScript miRNA Assays for microRNAs that regulate DAGLA (see all 72):
    hsa-miR-323-3p hsa-miR-3607-3p hsa-miR-300 hsa-miR-1914* hsa-miR-485-3p hsa-miR-30d hsa-miR-4267 hsa-miR-30a
    SwitchGear 3'UTR luciferase reporter plasmidDAGLA 3' UTR sequence
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    Additional mRNA sequence: 

    AB014559.2 AY275377.1 BC150176.1 BC150195.1 BC152453.1 

    2 DOTS entries:

    DT.105877  DT.92419455 

    24/40 AceView cDNA sequences (see all 40):

    T16247 BI964152 AI216160 BM068819 NM_006133 AY275377 AI140579 BM126486 
    CK904653 BI964010 CR596071 BI918354 BI752614 BG764500 BE615414 AB014559 
    BM054786 BE907563 BE531065 BE531188 BM763121 BG748842 BE735837 BX452062 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAGLA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CACTCTCTTA
    DAGLA Expression
    About this image


    See DAGLA Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAGLA

    SOURCE GeneReport for Unigene cluster: Hs.241564

    UniProtKB/Swiss-Prot: DGLA_HUMAN, Q9Y4D2
    Tissue specificity: Highly expressed in brain and pancreas

        SABiosciences Custom PCR Arrays for DAGLA
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAGLA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DAGLA gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dagla1 , 5 diacylglycerol lipase, alpha1, 5 89.41(n)1
    97.41(a)1
      19 (6.55 cM)5
    2690601  NM_198114.21  NP_932782.21 
     102452655 
    chicken
    (Gallus gallus)
    Aves DAGLA1 diacylglycerol lipase, alpha 79.79(n)
    89.31(a)
      426017  XM_423696.3  XP_423696.3 
    lizard
    (Anolis carolinensis)
    Reptilia DAGLA6
    diacylglycerol lipase, alpha
    86(a)
    1 ↔ 1
    GL343235.1(1578185-1640139)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ640573.12   -- 73.13(n)    BJ640573.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dagla1 diacylglycerol lipase, alpha 68.16(n)
    72.97(a)
      569398  XM_692781.4  XP_697873.4 
    fruit fly
    (Drosophila melanogaster)
    Insecta inaE1 inactivation no afterpotential E 48.81(n)
    38.89(a)
      32343  NM_001144723.1  NP_001138195.1 


    ENSEMBL Gene Tree for DAGLA (if available)
    TreeFam Gene Tree for DAGLA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DAGLA gene
    DAGLB2  
    1 SIMAP similar gene for DAGLA using alignment to 2 protein entries:     DGLA_HUMAN (see all proteins):
    DAGLB

    DAGLA for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1233 SNPs in DAGLA are shown (see all 1233)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1881809431,2
    --61445945(+) CTCTGC/TCTCCC 1 -- us2k10--------
    rs1155313611,2
    F--61446038(+) CTTTGG/ATAGAG 1 -- us2k11Minor allele frequency- A:0.04WA 118
    rs1807083111,2
    C--61446153(+) CCCCTA/GGCCGA 1 -- us2k10--------
    rs1850470341,2
    --61446161(+) CGACAA/GTCTTT 1 -- us2k10--------
    rs1902960531,2
    --61446217(+) TCAACG/TGGGAA 1 -- us2k10--------
    rs1452878721,2
    --61446283(+) TGACCA/GTGGCC 1 -- us2k10--------
    rs49633041,2
    C,F,A--61446352(+) ATCCAG/ATCTGG 1 -- us2k110Minor allele frequency- A:0.45NA WA CSA EA 372
    rs79315631,2
    C,F,A,H--61446425(+) AGTTGT/GCCCTT 1 -- us2k124Minor allele frequency- G:0.47NS EA NA WA 2762
    rs1491619961,2
    --61446483(+) TCCTCC/TTTGAA 1 -- us2k10--------
    rs79423871,2
    C,F--61446501(+) AGGTGC/ACCCAC 1 -- us2k11Minor allele frequency- A:0.11WA 118

    HapMap Linkage Disequilibrium report for DAGLA (61447905 - 61514474 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DAGLA:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv1003572CNV Deletion20482838
    nsv528697CNV Loss19592680
    nsv897611CNV Loss21882294
    nsv897612CNV Loss21882294
    nsv832179CNV Loss17160897
    dgv1153n71CNV Loss21882294
    dgv1152n71CNV Loss21882294
    nsv897607CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 614015    OMIM disorders: --

    UniProtKB/Swiss-Prot: DGLA_HUMAN, Q9Y4D2
  • Spinocerebellar ataxia 20 (SCA20) [MIM:608687]: Spinocerebellar ataxia is a clinically and genetically
    heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor
    coordination of hands, speech and eye movements, due to degeneration of the cerebellum with variable involvement
    of the brainstem and spinal cord. SCA20 is an autosomal dominant, adult-onset form characterized by dysarthria
    due to spasmodic dysphonia followed by slowly progressive ataxia. Note=The disease may be caused by mutations
    affecting the gene represented in this entry. A copy number variation consisting of a 260-kb duplication at
    chromosome 11q12.2-12.3 is responsible for SCA20. The critical gene within the duplicated segment may be DAGLA

  • 5 diseases for DAGLA:    About MalaCards
    spinocerebellar ataxia type 20    spasmodic dysphonia    spinocerebellar ataxia    smallpox
    ataxia


    DAGLA for disorders           About GeneDecksing

    Genetic Association Database (GAD): DAGLA

    Export disorders for DAGLA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAGLA gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with DAGLA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2, 3 Ishikawa K.... Ohara O. (1998)
    2. Genetic loci associated with plasma phospholipid n-3 f atty acids: a meta-analysis of genome-wide association studies from the CHARGE C onsortium. (PubMed id 21829377)1, 4 Lemaitre R.N....Steffen L.M. (2011)
    3. A duplication at chromosome 11q12.2-11q12.3 is associ ated with spinocerebellar ataxia type 20. (PubMed id 18801880)1, 2 Knight M.A....Singleton A.B. (2008)
    4. Stimulation of endocannabinoid formation in brain slice cultures through activation of group I metabotropic glutamate receptors. (PubMed id 16051747)1, 2 Jung K.-M.... Piomelli D. (2005)
    5. Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain. (PubMed id 14610053)1, 2 Bisogno T.... Doherty P. (2003)
    6. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    7. Developmental trajectory of the endocannabinoid system in human dorsolateral prefrontal cortex. (PubMed id 22827915)1 Long L.E....Weickert C.S. (2012)
    8. Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients. (PubMed id 22610502)1 Kennedy R.B....Poland G.A. (2012)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    10. Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures. (PubMed id 12486725)6 Kurz M....Kramer W. (2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 747 HGNC: 1165 AceView: C11orf11 Ensembl:ENSG00000134780 euGenes: HUgn747
    ECgene: DAGLA Kegg: 747 H-InvDB: DAGLA

    (According to HUGE)
    About This Section
    HUGE: KIAA0659

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAGLA Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DAGLA gene:
    Search GeneIP for patents involving DAGLA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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