Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DAG1 Gene

protein-coding   GIFtS: 72
GCID: GC03P049482

Dystroglycan 1 (Dystrophin-Associated Glycoprotein 1)

  See DAG1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Dystroglycan 1 (Dystrophin-Associated Glycoprotein 1)1 2     156DAG2
DAG2 5     A3a2
MDDGC92 5     AGRNR2
alpha-dystroglycan1     MDDGC72
beta-dystroglycan1     dystroglycan2
Dystrophin-Associated Glycoprotein-11     Dystrophin-Associated Glycoprotein 13

External Ids:    HGNC: 26661   Entrez Gene: 16052   Ensembl: ENSG000001734027   OMIM: 1282395   UniProtKB: Q141183   
ORGUL members:         

Export aliases for DAG1 gene to outside databases

Previous GC identifers: GC03M048929 GC03M048831 GC03P049362 GC03P049466


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DAG1 Gene:
Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage
between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the
site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in
Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix, rendering
muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2
in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties
but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same
protein.(provided by RefSeq, Apr 2010)

GeneCards Summary for DAG1 Gene:
DAG1 (dystroglycan 1 (dystrophin-associated glycoprotein 1)) is a protein-coding gene. Diseases associated with DAG1 include lassa fever, and muscle-eye-brain disease with bilateral multicystic leucodystrophy. GO annotations related to this gene include structural constituent of muscle and calcium ion binding.

UniProtKB/Swiss-Prot: DAG1_HUMAN, Q14118
Function: The dystroglycan complex is involved in a number of processes including laminin and basement membrane
assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration,
and epithelial polarization
Function: Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both
extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. Receptor for laminin-2
(LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for M.leprae in peripheral nerve
Schwann cells but only in the presence of the G-domain of LAMA2, and for lymphocytic choriomeningitis virus, Old
World Lassa fever virus, and clade C New World arenaviruses
Function: Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular
matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for
both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell
adhesion-mediated signaling and implicated in cell polarity

Gene Wiki entry for DAG1 (Dystroglycan) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000003.11  NC_018914.2  NT_022517.19  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAG1 gene promoter:
         c-Fos   AP-1   ATF-2   c-Jun   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAG1 promoter sequence
   Search Chromatin IP Primers for DAG1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAG1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 3p21   Ensembl cytogenetic band:  3p21.31   HGNC cytogenetic band: 3p21

DAG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAG1 gene location

GeneLoc information about chromosome 3         GeneLoc Exon Structure

GeneLoc location for GC03P049482:  view genomic region     (about GC identifiers)

Start:
49,506,146 bp from pter      End:
49,573,048 bp from pter
Size:
66,903 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DAG1_HUMAN, Q14118 (See protein sequence)
Recommended Name: Dystroglycan precursor  
Size: 895 amino acids; 97441 Da
Subunit: Monomer. Heterodimer of alpha- and beta-dystroglycan subunits which are the central components of the
dystrophin-glycoprotein complex. This complex then can form a dystrophin-associated glycoprotein complex (DGC)
which is composed of three subcomplexes: a cytoplasmic complex comprised of DMD (or UTRN), DTNA and a number of
syntrophins, such as SNTB1, SNTB2, SNTG1 and SNTG2, the transmembrane dystroglycan complex, and the
sarcoglycan-sarcospan complex. Interacts (via the N-terminal of alphaDAG1) with LARGE; the interaction enhances
laminin binding (By similarity). Interacts with SGCD. Interacts with AGR2 and AGR3. Interacts (betaDAG1) with
DMD; the interaction is inhibited by phosphorylaion on the PPXY motif. Interacts (betaDAG1, via its PPXY motif)
with UTRN (via its WWW and ZZ domains); the interaction is inhibited by phosphorylation on the PPXY motif.
Interacts (betaDAG1, via its phosphorylated PPXY motif) with the SH2 domain-containing proteins, FYN, CSK, NCK
and SHC. Interacts (betaDAG1) with CAV3 (via a central WW-like domain); the interaction disrupts the binding of
DMD. BetaDAG1 directly interacts with ANK3, but not with ANK2; this interaction does not interfere with
DMD-binding and is required for retention at costameres (By similarity)
1 PDB 3D structure from and Proteopedia for DAG1:
1EG4 (3D)    
Secondary accessions: A8K6M7 Q969J9

Explore the universe of human proteins at neXtProt for DAG1: NX_Q14118

Explore proteomics data for DAG1 at MOPED

Post-translational modifications: 

  • O- and N-glycosylated. Alpha-dystroglycan is heavily O-glycosylated comprising of up to two thirds of its mass and
    the carbohydrate composition differs depending on tissue type. Mucin-type O-glycosylation is important for ligand
    binding activity. O-mannosylation of alpha-DAG1 is found in high abundance in both brain and muscle where the
    most abundant glycan is Sia-alpha-2-3-Gal-beta-1-4-Glc-NAc-beta-1-2-Man. In muscle, glycosylation on Thr-379 by a
    phosphorylated O-mannosyl glycan with the structure
    2-(N-acetylamido)-2-deoxygalactosyl-beta-1,3-2-(N-acetylamido)-2-deoxyglucosyl-beta-1,4-6-phosphomannose is
    mediated by like-acetylglucosaminyltransferase (LARGE) protein and is required for laminin binding.
    O-mannosylation is also required for binding lymphocytic choriomeningitis virus, Old World Lassa fever virus, and
    clade C New World arenaviruses. The O-glycosyl hexose on Thr-367, Thr-369, Thr-372, Thr-381 and Thr-388 is
    probably mannose. O-glycosylated in the N-terminal region with a core 1 or possibly core 8 glycan. The beta
    subunit is N-glycosylated1
  • Autolytic cleavage produces the alpha and beta subunits. In cutaneous cells, as well as in certain pathological
    conditions, shedding of beta-dystroglcan can occur releasing a peptide of about 30 kDa1
  • SRC-mediated phosphorylation of the PPXY motif of the beta subunit recruits SH2 domain-containing proteins, but
    inhibits binding to WWW domain-containing proteins, DMD and UTRN. This phosphorylation also inhibits nuclear
    entry1
  • Ubiquitination2 at Lys782, Lys793
  • Glycosylation2 at Thr63, Asn141, Thr367, Thr369, Thr372, Thr379, Thr381, Thr388, Ser430, Thr431,
                                 Thr436, Ser438, Thr439, Ser441, Thr442, Thr443, Thr444, Thr445, Thr446, Thr450 (see all 36)
  • Modification sites at PhosphoSitePlus

  • See DAG1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (13 alternative transcripts): 
    NP_001159400.2  NP_001171105.1  NP_001171106.1  NP_001171107.1  NP_001171108.1  NP_001171109.1  NP_001171110.1  NP_001171111.1  
    NP_001171112.1  NP_001171113.1  NP_001171114.1  NP_001171115.1  NP_004384.4  

    ENSEMBL proteins: 
     ENSP00000412067   ENSP00000312435   ENSP00000405859   ENSP00000388833   ENSP00000387859  
     ENSP00000415321   ENSP00000410145   ENSP00000401382   ENSP00000402443   ENSP00000401805  
     ENSP00000440705   ENSP00000442600   ENSP00000440590   ENSP00000439334   ENSP00000438421  
    Reactome Protein details: Q14118

    DAG1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for DAG1 (Dystroglycan)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DAG1
    GenScript Custom Purified and Recombinant Proteins Services for DAG1
    Novus Biologicals DAG1 Protein
    Novus Biologicals DAG1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for DAG1
    Cloud-Clone Corp. Proteins for DAG1

     
    Search eBioscience for Proteins for DAG1 

    DAG1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of DAG1
    R&D Systems Antibodies for DAG1 (Dystroglycan)
    OriGene Antibodies for DAG1
    OriGene Custom Antibody Services for DAG1
    Novus Biologicals DAG1 Antibodies
    Abcam antibodies for DAG1
    Cloud-Clone Corp. Antibodies for DAG1
    ThermoFisher Antibodies for DAG1
    LSBio Antibodies in human, mouse, rat for DAG1

    DAG1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DAG1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DAG1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DAG1
    Cloud-Clone Corp. CLIAs for DAG1
    Search eBioscience for ELISAs for DAG1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    5 InterPro protein domains:
     IPR015919 Cadherin-like
     IPR013783 Ig-like_fold
     IPR006644 Cadg
     IPR027468 Alpha-dystroglycan_domain_2
     IPR008465 DAG1

    Graphical View of Domain Structure for InterPro Entry Q14118

    ProtoNet protein and cluster: Q14118

    2 Blocks protein domains:
    IPB006644 Dystroglycan-type cadherin-like domain
    IPB008465 Dystroglycan


    UniProtKB/Swiss-Prot: DAG1_HUMAN, Q14118
    Similarity: Contains 1 peptidase S72 domain


    Find genes that share domains with DAG1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAG1_HUMAN, Q14118
    Function: The dystroglycan complex is involved in a number of processes including laminin and basement membrane
    assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration,
    and epithelial polarization
    Function: Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both
    extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. Receptor for laminin-2
    (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for M.leprae in peripheral nerve
    Schwann cells but only in the presence of the G-domain of LAMA2, and for lymphocytic choriomeningitis virus, Old
    World Lassa fever virus, and clade C New World arenaviruses
    Function: Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular
    matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for
    both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell
    adhesion-mediated signaling and implicated in cell polarity

         Genatlas biochemistry entry for DAG1:
    dystrophin associated glycoprotein 1 (97kDa).expressed in muscle,epithelial cells and cells of the nervous
    system,precursor of the 43kDa DYS associated transmembrane glycoprotein DAG beta (dystroglycan beta),binding to
    dystrophin or utrophin or one of their truncated forms by its cytoplasmic tail,and a 156kDa extracellular
    component DAG alpha (dystroglycan alpha) membrane associated through a non covalent interaction with the
    extracellular domain of DAG beta,also bound to laminin 2 (alpha 2,beta 1,gamma 1) and to agrin and
    perlecan,multifunctional protein critical in the formation of extracellular matrix in cells contacting basement
    membranes,connecting the intracellular cytoskeleton to ECM and protecting muscle from mechanical injury,receptor
    for lymphocytic choriomeningitis virus and Lassa fever virus,also acting as a Schwann cell receptor for
    mycobacterium leprae,in the presence of the G domain of LAMA2

         Gene Ontology (GO): Selected molecular function terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001618virus receptor activity IEA--
    GO:0002162dystroglycan binding IEA--
    GO:0003779actin binding IDA18341635
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI10767429
         
    Find genes that share ontologies with DAG1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DAG1:
     Synthetic lethal with Ras 

         13 MGI mutant phenotypes (inferred from 7 alleles(MGI details for Dag1):
     behavior/neurological  cardiovascular system  cellular  craniofacial  embryogenesis 
     growth/size/body  homeostasis/metabolism  mortality/aging  muscle  nervous system 
     normal  other  vision/eye 

    Find genes that share phenotypes with DAG1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DAG1: Dag1tm3Kcam Dag1tm1Kcam

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DAG1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DAG1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DAG1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAG1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DAG1:
    hsa-mir-3676-3p (MIRT052870), hsa-mir-222-3p (MIRT046717), hsa-mir-18a-3p (MIRT040760), hsa-mir-1229-3p (MIRT036312), hsa-mir-30a-5p (MIRT028523), hsa-mir-423-5p (MIRT038178), hsa-mir-29a-3p (MIRT005906), hsa-mir-155-5p (MIRT020649)

    Block miRNA regulation of human, mouse, rat DAG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAG1 (see all 47):
    hsa-miR-140-5p hsa-miR-4307 hsa-miR-300 hsa-miR-25 hsa-miR-4305 hsa-miR-1258 hsa-miR-766 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidDAG1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DAG1
    Predesigned siRNA for gene silencing in human, mouse, rat DAG1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DAG1

    Clone
    Products:
         
    OriGene clones in human, mouse for DAG1 (see all 58)
    OriGene ORF clones in mouse, rat for DAG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 13): DAG1 (NM_004393)
    Sino Biological Human cDNA Clone for DAG1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAG1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DAG1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DAG1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAG1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DAG1_HUMAN, Q14118: Alpha-dystroglycan: Secreted, extracellular space
    DAG1_HUMAN, Q14118: Beta-dystroglycan: Cell membrane; Single-pass type I membrane protein. Cytoplasm,
    cytoskeleton. Nucleus, nucleoplasm. Cell membrane, sarcolemma (By similarity). Cell junction, synapse,
    postsynaptic cell membrane (By similarity). Note=The monomeric form translocates to the nucleus via the action of
    importins and depends on RAN. Nuclear transport is inhibited by Tyr-892 phosphorylation. In skeletal muscle, this
    phosphorylated form locates to a vesicular internal membrane compartment. In muscle cells, sarcolemma
    localization requires the presence of ANK2, while localization to costameres requires the presence of ANK3.
    Localizes to neuromuscular junctions (NMJs) in the presence of ANK2 (By similarity). In peripheral nerves,
    localizes to the Schwann cell membrane. Colocalizes with ERM proteins in Schwann-cell microvilli
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    extracellular5
    nucleus5
    plasma membrane5
    golgi apparatus2
    endoplasmic reticulum1

    Gene Ontology (GO): Selected cellular component terms (see all 24):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005604basement membrane IDA19348877
    GO:0005615extracellular space IDA18201566
    GO:0005654nucleoplasm IDA18764929
    GO:0005737cytoplasm IDA18764929

    Find genes that share ontologies with DAG1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for DAG1 About   (see all 13)  
    See pathways by source

    SuperPathContained pathways About
    1Hypertrophic cardiomyopathy (HCM)
    Hypertrophic cardiomyopathy (HCM)0.75
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)0.54
    Dilated cardiomyopathy0.75
    Arrhythmogenic right ventricular cardiomyopathy0.54
    2Non-Canonical Wnt Pathway
    Non-Canonical Wnt Pathway0.53
    3Allograft rejection
    Viral myocarditis0.40
    4DREAM Repression and Dynorphin Expression
    nNOS Signaling in Skeletal Muscle0.37
    5Non-integrin membrane-ECM interactions
    Non-integrin membrane-ECM interactions0.35


    Find genes that share SuperPaths with DAG1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for DAG1
        Muscular Dystrophies and Dystrophin-Glycoprotein Complex
    nNOS Signaling in Skeletal Muscle
    Agrin Interactions at Neuromuscular Junction

    3 BioSystems Pathways for DAG1
        Integrated Breast Cancer Pathway
    Integrated Pancreatic Cancer Pathway
    Arrhythmogenic right ventricular cardiomyopathy

    1 Sino Biological Pathway for DAG1
        Non-Canonical Wnt Pathway

    3 Reactome Pathways for DAG1
        ECM proteoglycans
    Integrin cell surface interactions
    Non-integrin membrane-ECM interactions


    5 Kegg Pathways  (Kegg details for DAG1):
        ECM-receptor interaction
    Hypertrophic cardiomyopathy (HCM)
    Arrhythmogenic right ventricular cardiomyopathy (ARVC)
    Dilated cardiomyopathy
    Viral myocarditis

        Pathway & Disease-focused RT2 Profiler PCR Array including DAG1: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DAG1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DAG1 (Q141181, 2, 3 ENSP000003124354) via UniProtKB, MINT, STRING, and/or I2D (see all 69)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UTRNP469392, 3, ENSP000003565154MINT-18977 MINT-18976 I2D: score=2 STRING: ENSP00000356515
    FYNP062412, 3, ENSP000003576564MINT-8111091 I2D: score=4 STRING: ENSP00000357656
    PIK3R1P279862, 3, ENSP000002743354MINT-8111787 I2D: score=3 STRING: ENSP00000274335
    SRCP129312, 3, ENSP000003509414MINT-8112939 I2D: score=5 STRING: ENSP00000350941
    NCK1P163331, 3, ENSP000002889864EBI-1755945,EBI-389883 I2D: score=3 STRING: ENSP00000288986
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002011morphogenesis of an epithelial sheet IEA--
    GO:0006509membrane protein ectodomain proteolysis IDA19946898
    GO:0006607NLS-bearing protein import into nucleus IDA--
    GO:0007016cytoskeletal anchoring at plasma membrane IMP18341635
    GO:0014044Schwann cell development ----

    Find genes that share ontologies with DAG1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAG1

    4 Novoseek inferred chemical compound relationships for DAG1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    acetylcholine 25 4 10366602 (1), 7744958 (1), 16531417 (1)
    polysaccharide 15.2 7 15788414 (2), 19587235 (2), 16466646 (1), 15848172 (1)
    calcium 0 2 9791728 (1), 12963372 (1)
    heparin 0 5 10619025 (2), 12963372 (2)



    Find genes that share compounds with DAG1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DAG1 gene (13 alternative transcripts): 
    NM_001165928.3  NM_001177634.2  NM_001177635.2  NM_001177636.2  NM_001177637.2  NM_001177638.2  NM_001177639.2  NM_001177640.2  
    NM_001177641.2  NM_001177642.2  NM_001177643.2  NM_001177644.2  NM_004393.5  

    Unigene Cluster for DAG1:

    Dystroglycan 1 (dystrophin-associated glycoprotein 1)
    Hs.76111  [show with all ESTs]
    Unigene Representative Sequence: NM_001165928
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22):
    ENST00000469139 ENST00000421560 ENST00000308775 ENST00000418588 ENST00000431960
    ENST00000452317 ENST00000435508 ENST00000452060 ENST00000466701 ENST00000428779
    ENST00000461987 ENST00000461492 ENST00000419218 ENST00000430636 ENST00000496474
    ENST00000475424 ENST00000479935 ENST00000515359(uc021wxz.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DAG1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAG1 (see all 47):
    hsa-miR-140-5p hsa-miR-4307 hsa-miR-300 hsa-miR-25 hsa-miR-4305 hsa-miR-1258 hsa-miR-766 hsa-miR-570
    SwitchGear 3'UTR luciferase reporter plasmidDAG1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DAG1
    Predesigned siRNA for gene silencing in human, mouse, rat DAG1
    Clone
    Products:
         
    OriGene clones in human, mouse for DAG1 (see all 58)
    OriGene ORF clones in mouse, rat for DAG1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 13): DAG1 (NM_004393)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAG1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAG1
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DAG1
    OriGene qSTAR qPCR primer pairs in human, mouse for DAG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DAG1
      QuantiTect SYBR Green Assays in human, mouse, rat DAG1
      QuantiFast Probe-based Assays in human, mouse, rat DAG1

    Additional mRNA sequence: 

    AK291692.1 AK297802.1 BC012740.2 BC014616.2 L19711.1 

    18 DOTS entries:

    DT.219807  DT.100659498  DT.95178088  DT.95075533  DT.120904326  DT.120904122  DT.91922083  DT.100780499 
    DT.120904198  DT.40116217  DT.75160208  DT.100742856  DT.120904533  DT.91765516  DT.95086220  DT.95193034 
    DT.100812868  DT.102840619 

    Selected AceView cDNA sequences (see all 499):

    AU119166 F31074 CF527970 AI570680 CR591955 BM718321 AI031721 BM479667 
    F26600 BX384229 BG291366 BF792431 AA339603 AA776392 AI362068 BC014616 
    BX280536 AA315848 BC012740 BQ230594 AL528227 BQ955254 BX402174 AA340773 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DAG1 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c · 2d ^ 3 ^ 4 ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9a · 9b · 9c · 9d · 9e · 9f · 9g ^ 10a · 10b · 10c
    SP1:                                      -                 -           -     -     -     -                                                               
    SP2:                                      -     -                                                                                                         
    SP3:                    -     -     -     -     -     -     -     -     -     -     -     -                                                               
    SP4:                                      -     -     -     -     -     -     -     -     -                                                               
    SP5:                                      -     -           -     -     -     -     -     -                                                               


    ECgene alternative splicing isoforms for DAG1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DAG1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CAGAGACGTG
    DAG1 Expression
    About this image


    DAG1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Skeletal Muscle (Muscoskeletal System)    fully expand to see all 14 entries
             Multinuclear Myocytes Lumbar Back Muscles
     
     Limb (Muscoskeletal System)    fully expand to see all 4 entries
             Multinuclear Myocytes Forelimb Dorsal Muscles
     
     Peripheral Nervous System (Nervous System)    fully expand to see all 2 entries
             Pro-myelinating Schwann Cells Peripheral Nerve Domain
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Third Ventricle
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    DAG1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAG1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.76111

    UniProtKB/Swiss-Prot: DAG1_HUMAN, Q14118
    Tissue specificity: Expressed in a variety of fetal and adult tissues. In epidermal tissue, located to the
    basement membrane. Also expressed in keratinocytes and fibroblasts

        Pathway & Disease-focused RT2 Profiler PCR Array including DAG1: 
              Skeletal Muscle: Myogenesis & Myopathy in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for DAG1
    OriGene qSTAR qPCR primer pairs in human, mouse for DAG1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DAG1
    QuantiTect SYBR Green Assays in human, mouse, rat DAG1
    QuantiFast Probe-based Assays in human, mouse, rat DAG1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAG1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals.

    Orthologs for DAG1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dag11 , 5 dystroglycan 11, 5 86.97(n)1
    93.51(a)1
      9 (59.08 cM)5
    131381  NM_001276492.11  NP_001263421.11 
     1082059585 
    chicken
    (Gallus gallus)
    Aves DAG11 dystroglycan 1 (dystrophin-associated glycoprotein more 72.99(n)
    77.22(a)
      100049058  NM_001097540.1  NP_001091009.1 
    lizard
    (Anolis carolinensis)
    Reptilia DAG16
    dystroglycan 1 (dystrophin-associated glycoprotein...
    76(a)
    1 ↔ 1
    2(146811198-146901552)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3985002 dystroglycan 73.51(n)    AY188392.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dag12 dystroglycan 1 75.1(n)   286829  AF483476.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Dg3 cytoskeletal anchoring cytoskeletal
    anchor protein
    31(a)     --


    ENSEMBL Gene Tree for DAG1 (if available)
    TreeFam Gene Tree for DAG1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DAG1 gene

    Find genes that share paralogs with DAG1           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for DAG1
    PGOHUM00000239710


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DAG1 (see all 1304)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 3 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0652664
    Muscular dystrophy-dystroglycanopathy limb-girdle C9 (MDDGC9)4--see VAR_0652662 T M mis40--------
    rs76223021,2
    C,F,Huntested149479581(+) ACTAAC/G/TACATA 13 -- int120NS EA NA WA 2346
    rs21311071,2,,4
    C,F,Huntested149480028(-) TCCCCC/GAGAGG 26 S W mis120Minor allele frequency- G:0.03NS EA MN NA WA CSA EU 6280
    rs23290241,2
    C,F,Huntested149480314(-) TGGAAG/AATGAG 13 -- int125Minor allele frequency- A:0.04NS EA NA WA CSA 1787
    rs23118011,2
    C,F,Huntested149500112(-) TCCTCT/CCCCCT 13 -- int1 trp321Minor allele frequency- C:0.04NS EA NA WA CSA 1643
    rs22290101,2
    C,F,Huntested149501734(+) GCCTTC/TGAGAT 26 F syn18Minor allele frequency- T:0.00MN NS EA NA 550
    rs18011431,2
    C,F,A,Huntested149502217(+) CTGCAC/TACAGT 26 H syn1 ese335Minor allele frequency- T:0.28MN NA EA NS CSA WA EU 9169
    rs10500881,2
    C,F,Huntested149502899(+) GAGAAT/CTCTTC 13 -- ut3124Minor allele frequency- C:0.49MN NS EA NA WA CSA 2538
    rs125831,2
    C,F,Huntested149503479(+) CAAGGG/TGTCTT 13 -- ut3120Minor allele frequency- T:0.23MN NS EA NA WA CSA 2425
    rs46251,2
    C,F,A,Huntested149504157(+) GTCCCA/GTGACT 13 -- ut31 ese322Minor allele frequency- G:0.27MN NS EA NA WA 2718

    HapMap Linkage Disequilibrium report for DAG1 (49506146 - 49573048 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for DAG1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2670969CNV Deletion23128226
    esv2670482CNV Deletion23128226
    esv2666668CNV Deletion23128226
    nsv237516CNV Loss16902084
    nsv834687CNV Loss17160897

    Human Gene Mutation Database (HGMD): DAG1
    Locus Specific Mutation Databases (LSDB): DAG1

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DAG1
    DNA2.0 Custom Variant and Variant Library Synthesis for DAG1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 128239   
    OMIM disorders: 613818  
    UniProtKB/Swiss-Prot: DAG1_HUMAN, Q14118
  • Muscular dystrophy-dystroglycanopathy limb-girdle C9 (MDDGC9) [MIM:613818]: An autosomal recessive
    muscular dystrophy showing onset in early childhood, and associated with mental retardation without structural
    brain anomalies. Note=The disease is caused by mutations affecting the gene represented in this entry. MDDGC7 is
    caused by DAG1 mutations that interfere with normal post-translational processing, resulting in defective DAG1
    glycosylation and impaired interactions with extracellular-matrix components. Other muscular
    dystrophy-dystroglycanopathies are caused by defects in enzymes involved in protein O-glycosylation

  • 12 diseases for DAG1:    
    About MalaCards
    lassa fever    muscle-eye-brain disease with bilateral multicystic leucodystrophy    muscular dystrophy-dystroglycanopathy , type c, 9    lymphocytic choriomeningitis
    peripheral nervous system disease    brain disease    sarcoglycanopathies    duchenne muscular dystrophy
    walker-warburg syndrome    fukuyama congenital muscular dystrophy    muscular dystrophy-dystroglycanopathy    muscular dystrophy

    5 diseases from the University of Copenhagen DISEASES database for DAG1:
    Myopathy     Neuropathy     Lassa fever     Lissencephaly
    Intellectual disability

    Find genes that share disorders with DAG1           About GenesLikeMe

    Selected Novoseek inferred disease relationships for DAG1 gene (see all 12)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    walker-warburg syndrome 87.3 3 17559086 (1), 19266496 (1), 16575835 (1)
    muscular dystrophies 86.9 21 16531417 (3), 15833426 (2), 15342399 (1), 15351499 (1) (see all 16)
    muscle-eye-brain disease 84.4 1 17559086 (1)
    lassa fever 79.3 4 15246261 (1), 17761532 (1), 16254363 (1), 16254364 (1)
    lymphocytic choriomeningitis 69 6 15246261 (1), 17761532 (1), 16254363 (1), 16254364 (1) (see all 6)
    muscular dystrophy duchenne 63.6 2 8113213 (1), 1461282 (1)
    breast carcinoma 28.9 3 12598319 (1), 19587235 (1)
    myopathy 24 1 16289897 (1)
    cancer 15.6 11 18808525 (4), 15341990 (1)
    necrosis 0 1 9436418 (1)

    Genetic Association Database (GAD): DAG1
    Human Genome Epidemiology (HuGE) Navigator: DAG1 (6 documents)

    Export disorders for DAG1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DAG1 gene, integrated from 10 sources (see all 196):
    (articles sorted by number of sources associating them with DAG1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of an Importin alpha/beta-recognized nuclear localization signal in beta-dystroglycan. (PubMed id 20512930)1, 2, 9 Lara-Chacon B.... Cisneros B. (J. Cell. Biochem. 2010)
    2. O Mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function. (PubMed id 16254364)1, 2, 9 Imperiali M....Oxenius A. (J. Virol. 2005)
    3. Nuclear translocation of beta-dystroglycan reveals a distinctive trafficking pattern of autoproteolyzed mucins. (PubMed id 18764929)1, 2, 9 Oppizzi M.L.... Muschler J.L. (Traffic 2008)
    4. O-mannosyl phosphorylation of alpha-dystroglycan is required for laminin binding. (PubMed id 20044576)1, 2, 9 Yoshida-Moriguchi T.... Campbell K.P. (Science 2010)
    5. Enzymatic processing of beta-dystroglycan recombinant ectodomain by MMP-9: identification of the main cleavage site. (PubMed id 19946898)1, 2, 9 Bozzi M.... Coletta M. (IUBMB Life 2009)
    6. Human dystroglycan: skeletal muscle cDNA, genomic structure, origin of tissue specific isoforms and chromosomal localization. (PubMed id 8268918)1, 2, 9 Ibraghimov-Beskrovnaya O.... Campbell K.P. (Hum. Mol. Genet. 1993)
    7. Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population. (PubMed id 19367581)1, 4 So H.C....Sham P.C. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    8. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    9. Association analysis of 3p21 with Crohn's disease in a New Zealand population. (PubMed id 20307617)1, 4 Morgan A.R....Ferguson L.R. (Hum. Immunol. 2010)
    10. Characterization of site-specific O-glycan structures within the mucin-like domain of {alpha}-dystroglycan from human skeletal muscle. (PubMed id 20507882)1, 2 Nilsson J.... Grahn A. (Glycobiology 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 1605 HGNC: 2666 AceView: DAG1 Ensembl:ENSG00000173402 euGenes: HUgn1605
    ECgene: DAG1 Kegg: 1605 H-InvDB: DAG1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DAG1 Pharmacogenomics, SNPs, Pathways
    LEIDEN Muscular Dystrophy page for DAG1 Scientfic Information about Duchenne and Duchenne-like muscular dystrophies.
    Wikipedia http://en.wikipedia.org/wiki/Dystroglycan

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DAG1 gene:
    Search GeneIP for patents involving DAG1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Kits and Assays available from EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Small Molecules at EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of DAG1
     
     EMD Millipore genomic analysis products

      
     Antibodies for DAG1 (Dystroglycan)   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Recombinant/Natural Proteins for DAG1 (Dystroglycan)   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DAG1   OriGene RNAi products in human, mouse, rat for DAG1  
     OriGene qPCR primer pairs and template standards for DAG1   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DAG1  
     OriGene qSTAR qPCR primer pairs in human, mouse for DAG1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DAG1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DAG1   OriGene Custom Protein Services for DAG1  

     
     
     Block miRNA regulation of human, mouse, rat DAG1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DAG1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAG1 Predesigned siRNA for gene silencing in human, mouse, rat DAG1
     QuantiFast Probe-based Assays in human, mouse, rat DAG1 QuantiTect SYBR Green Assays in human, mouse, rat DAG1
     PCR Arrays including human, mouse, rat DAG1 Search Chromatin IP Primers for DAG1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DAG1  GeneGlobe Interaction Network for DAG1
     Regulatory tfbs in DAG1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DAG1 GenScript cDNA clones with any tag delivered in your preferred vector for DAG1
     GenScript Custom Assay Services for DAG1 GenScript Custom overexpressing Cell Line Services for DAG1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DAG1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for DAG1
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DAG1 antibodies
     DAG1 proteins
     DAG1 lysates
     Antibodies for DAG1
     See all of Abcam's Antibodies, Kits and Proteins for DAG1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Recombinant Protein for DAG1
     Proteins for DAG1
     Antibodies for DAG1
     ELISAs for DAG1
     CLIAs for DAG1



     Browse ESI BIO Cell Lines and PureStem Progenitors for DAG1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAG1
     SwitchGear 3'UTR luciferase reporter plasmids for DAG1
     SwitchGear Promoter luciferase reporter plasmids for DAG1
     ThermoFisher Antibodies for DAG1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAG1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DAG1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DAG1
     LSBio Antibodies in human, mouse, rat for DAG1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DAG1
      Search eBioscience for proteins for DAG1
      Search eBioscience for elisas for DAG1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DAG1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4