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DAG1 Gene

protein-coding GIFtS: 66

GC03P049482

dystroglycan 1 (dystrophin-associated glycoprotein 1)
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
156DAG ^¹, ²
A3a ^¹, ²
AGRNR ^¹, ²
DAG ^¹, ², ⁵
alpha-dystroglycan ^²
beta-dystroglycan ^²

Descriptions
Dystrophin-associated glycoprotein 1 ^³
dystroglycan 1 ^²
dystroglycan 1 (dystrophin-associated glycoprotein 1) ^²
dystrophin-associated glycoprotein-1 ^²

External Ids
HGNC: 2666¹
Entrez Gene: 1605²
UniProtKB: Q14118³
Ensembl: ENSG00000173402⁷

Search outside databases for aliases for DAG1 gene

Previous GC identifers: GC03M048929 GC03M048831 GC03P049362 GC03P049466

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for DAG1:

Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a

linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a

candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The

dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage

between the sarcolemma and extracellular matrix, rendering muscle fibers more susceptible to

necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell

membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but

not protein sequence. [provided by RefSeq]

UniProtKB/Swiss-Prot: DAG1_HUMAN, Q14118

Function: Forms part of the dystrophin-associated protein complex (DAPC) which may link the

cytoskeleton to the extracellular matrix. Alpha-dystroglycan functions as a laminin receptor.

Binds to several types of arenaviruses. Is a target for the entry of Mycobacterium leprae into

peripheral nerve Schwann cells

Gene Wiki entry for DAG1 (Dystroglycan)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
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Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DAG1 gene

Entrez Gene cytogenetic band: 3p21 Ensembl cytogenetic band: 3p21.31 HGNC cytogenetic band: 3p21

DAG1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 3 GeneLoc Exon Structure

GeneLoc location for GC03P049482: (about GC identifiers)

Start:	49,482,569 bp from pter
End:	49,548,052 bp from pter
Size:	65,484 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000003.10 NT_022517.17

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DAG1_HUMAN, Q14118 (See protein sequence)

Recommended Name: Dystroglycan precursor

Size: 895 amino acids; 97441 Da

Subunit: Interacts with SGCD (By similarity). Interacts with AGR2 and AGR3

Subcellular location: Alpha-dystroglycan: Secreted, extracellular space

Subcellular location: Beta-dystroglycan: Cell membrane; Single-pass type I membrane protein.

Cytoplasm, cytoskeleton

PDB structures from and Proteopedia :

1EG4 (3D)

Secondary accessions: A8K6M7 Q969J9

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_004384.2

ENSEMBL proteins:

ENSP00000312435

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (beta Dystroglycan, Alpha Dystroglycan)
	Human Recombinant Proteins from Abnova (DAG1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

5/9 Gene Ontology (GO) cellular component terms (links to tree view) (see all 9 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005604	basement membrane	IEA	--
GO:0005624	membrane fraction	TAS	8798547
GO:0005737	cytoplasm	IEA	--
GO:0005887	integral to plasma membrane	TAS	8798547

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Antibodies for DAG1:

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of DAG1
	Sigma-Aldrich Antibodies for DAG1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (beta Dystroglycan, Alpha Dystroglycan), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DAG1)
	Novus Biologicals Antibodies for DAG1

Assays for DAG1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q14118

ProtoNet protein and cluster: Q14118

2 Blocks protein families:

IPB006644 Dystroglycan-type cadherin-like domain

IPB008465 Dystroglycan

UniProtKB/Swiss-Prot: DAG1_HUMAN, Q14118

Similarity: Contains 1 peptidase S72 domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAG1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DAG1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004393

Applied Biosystems Silencer® siRNAs for DAG1

Sigma-Aldrich siRNA and siRNA Panels for DAG1

Sigma-Aldrich shRNA Panels and shRNA for DAG1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DAG1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_004393
Myc/DDK tagged cDNA clone in CMV expression vector: NM_004393
untagged cDNA clone in CMV expression vector: NM_004393

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_004393

UniProtKB/Swiss-Prot: DAG1_HUMAN, Q14118

Function: Forms part of the dystrophin-associated protein complex (DAPC) which may link the

cytoskeleton to the extracellular matrix. Alpha-dystroglycan functions as a laminin receptor.

Binds to several types of arenaviruses. Is a target for the entry of Mycobacterium leprae into

peripheral nerve Schwann cells

Genatlas biochemistry entry for DAG1:

dystrophin associated glycoprotein 1 (97kDa).expressed in muscle,epithelial cells and cells of the

nervous system,precursor of the 43kDa DYS associated transmembrane glycoprotein DAG beta

(dystroglycan beta),binding to dystrophin or utrophin or one of their truncated forms by its

cytoplasmic tail,and a 156kDa extracellular component DAG alpha (dystroglycan alpha) membrane

associated through a non covalent interaction with the extracellular domain of DAG beta,also bound

to laminin 2 (alpha 2,beta 1,gamma 1) and to agrin and perlecan,multifunctional protein critical

in the formation of extracellular matrix in cells contacting basement membranes,connecting the

intracellular cytoskeleton to ECM and protecting muscle from mechanical injury,receptor for

lymphocytic choriomeningitis virus and Lassa fever virus,also acting as a Schwann cell receptor

for mycobacterium leprae,in the presence of the G domain of LAMA2

7 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dag1):

craniofacial	embryogenesis	growth/size	homeostasis/metabolism	lethality-prenatal/perinatal
muscle	nervous system

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0005515	protein binding	IPI	9417121

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for DAG1 (Your Favorite Gene powered by Ingenuity)

Agrin Interactions at Neuromuscular Junction

GeneDecks DAG1 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for DAG1

5/57 Interacting proteins for DAG1 (Q14118^{1, 2} ENSP00000312435³) via UniProtKB, MINT, and/or STRING (see all 57 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
UTRN	P46939², ENSP00000356515³	MINT-18977 MINT-18976 STRING (score=.992)
SRC	P12931¹, ENSP00000362659³	EBI-1755945, EBI-621482 STRING (score=.99)
GRB2	P62993¹, ENSP00000339007³	EBI-1755945, EBI-401755 STRING (score=.935)
FYN	P06241¹, ENSP00000357656³	EBI-1755945, EBI-515315 STRING (score=.802)
NCK1	P16333¹, ENSP00000288986³	EBI-1755945, EBI-389883 STRING (score=.772)

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3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002011	morphogenesis of an epithelial sheet	IEA	--
GO:0006461	protein complex assembly	TAS	1741056
GO:0006936	muscle contraction	TAS	1406935

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DAG1
1 Novoseek chemical compound relationship for DAG1 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
calcium	0.00	2	9791728 (1), 12963372 (1)

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(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAG1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DAG1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_004393

Sigma-Aldrich siRNA and siRNA Panels for DAG1

Sigma-Aldrich shRNA Panels and shRNA for DAG1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_004393

REFSEQ mRNAs for DAG1 gene:

NM_004393.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_004393

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_004393
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_004393
                                 untagged cDNA clone in CMV expression vector: NM_004393

Additional cDNA sequence:

AK291692.1 AK297802.1 BC012740.2 BC014616.2 CR591955.1 CR592448.1 L19711.1

17 DOTS entries:

DT.219807 DT.100659498 DT.95178088 DT.120904326 DT.95075533 DT.120904122 DT.91922083 DT.100780499

DT.120904198 DT.75160208 DT.102840619 DT.120904533 DT.40116217 DT.91765516 DT.95086220 DT.100742856

DT.95193034

24/499 AceView cDNA sequences (see all 499 ):

BQ230594 BM718321 BC012740 BF435689 CD514832 BF914772 F37039 AA339603

BF035364 AI932573 BM709238 BX384229 AI570680 CR591955 AA340773 BQ955254

BX280536 BG983242 CF527970 F31074 AU119166 AI031721 BM479667 AA315848

highest scoring ESTs for DAG1:

L19711 AA312841 AA323412 AA339603 AA345421 AA349783 AA350768 AA371984 AA507004 AA603599

Unigene Cluster for DAG1:

Dystroglycan 1 (dystrophin-associated glycoprotein 1)

Hs.76111 [show with all ESTs]

Unigene Representative Sequence: NM_004393

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for DAG1 (see all 11 )

ExUns:	1a	·	1b	·	1c	^	2a	·	2b	·	2c	·	2d	^	3	^	4	^	5a	·	5b	^	6	^	7	^	8a	·	8b	^	9a	·	9b	·	9c	·	9d	·	9e	·	9f	·	9g	^	10a	·	10b	·	10c
SP1:													-						-				-		-		-		-
SP2:													-		-
SP3:							-		-		-		-		-		-		-		-		-		-		-		-
SP4:													-		-		-		-		-		-		-		-		-
SP5:													-		-				-		-		-		-		-		-

About this scheme

ECgene alternative splicing isoforms for DAG1

1 Ensembl transcript including schematic representation:

ENST00000308775

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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DAG1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DAG1

¹ / ² / ³

5 probe-sets matching DAG1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
36989_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	L19711	1.00	1.00	1.00	1
212128_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AW411370	0.80	1.00	0.91	1
205417_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_004393	0.60	1.00	0.82	1
212128_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
205417_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks DAG1 for binary patterns associated with the probe-sets selected above

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: --

SOURCE GeneReport for Unigene cluster: Hs.76111
Expression variation in blood from EXPOLDB for DAG1
UniProtKB/Swiss-Prot: DAG1_HUMAN, Q14118
Tissue specificity: Expressed in a variety of fetal and adult tissues

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DAG1 gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DAG1¹	--	dystroglycan 1 (dystrophin-associated glycoprotein more	88.79(n) 95.18(a)	476623 XM_533827.2 XP_533827.2
chimpanzee (Pan troglodytes)	DAG1¹	--	dystroglycan 1 (dystrophin-associated glycoprotein more	99.63(n) 99.44(a)	460372 XM_001164754.1 XP_001164754.1
cow (Bos taurus)	DAG1¹	--	dystroglycan 1 (dystrophin-associated glycoprotein more	87.82(n) 93.18(a)	281439 NM_174162.1 NP_776587.1
rat (Rattus norvegicus)	Dag1¹	--	dystroglycan 1 (dystrophin-associated glycoprotein more	86.04(n) 92.95(a)	114489 XM_343483.3 XP_343484.1
mouse (Mus musculus)	Dag1^{1, 5}	9 (60.00 cM)⁵	dystroglycan 1^{1, 5}	86.97(n)¹ 93.51(a)¹	13138¹ NM_010017.2¹ NP_034147.1¹ AA407500⁵ AI325151⁵ (see all 22)

About this table Species with no ortholog for DAG1

ENSEMBL Gene Tree for DAG1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
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10/375 NCBI SNPs in DAG1 are shown (see all 375 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 64)

AB	SNP ID	Valid	Chr 3 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs4625^1,2	A,C,F,H	49547144(+)	`GTCCCA/GTGACT`	1	--	ut3¹ ese³		6		MN EU EA WA	790
	rs1050088^1,2	C,F,H	49545886(+)	`GAGAAC/TTCTTC`	1	--	ut3¹		9		MN EU EA WA	1022
	rs12583^1,2	C,F,H	49546466(+)	`CAAGGG/TGTCTT`	1	--	ut3¹		3		MN EU	488
	rs4855839^1,2	A,C,F	49482851(-)	`AGGACT/CGCGGC`	1	--	ut5¹ ese³		2		MN EA	1252
	rs6446283^1,2	C,F,H	49547898(+)	`GATGGC/TCGTTG`	1	--	ut3¹ ese³		4		EU EA WA	418
	rs2131107^1,2	C,F,H	49523012(-)	`TCCCCC/GAGAGG`	1	W/S	mis¹		5		EU EA WA MN	464
--	rs6797164^1,2	C,F,H	49481303(+)	`ttttgT/Cagagg`	1	--	ng5¹ tfbs³		4		EU EA WA	402
	rs7610269^1,2	F,H	49548430(+)	`CCTGGG/ATAGGG`	1	--	ng3¹		4		EU EA WA	420
	rs4855840^1,2	C	49482516(-)	`CGGCCA/CGCACC`	1	--	ng5¹		0	--	--	--	--
	rs1801143^1,2	A,C,F,H	49545204(+)	`CTGCAC/TACAGT`	1	H/H	syn¹ ese³		14		MN NA EA EU WA	1432

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HapMap Linkage Disequilibrium images for DAG1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 128239

10/12 Novoseek disease relationships for DAG1 gene (see all 12 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
walker-warburg syndrome	87.16	2	17559086 (1), 16575835 (1)
muscular dystrophies	86.95	18	16531417 (3), 15833426 (2), 15342399 (1), 15351499 (1) (see all 13)
muscle-eye-brain disease	82.94	1	17559086 (1)
lassa fever	80.92	4	15246261 (1), 17761532 (1), 16254363 (1), 16254364 (1)
lymphocytic choriomeningitis	71.24	6	15246261 (1), 17761532 (1), 16254363 (1), 16254364 (1) (see all 6)
muscular dystrophy duchenne	63.58	2	8113213 (1), 1461282 (1)
myopathy	27.45	1	16289897 (1)
breast carcinoma	25.35	2	12598319 (1)
cancer	7.56	11	18808525 (4), 15341990 (1)
necrosis	0.00	1	9436418 (1)

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Human Gene Mutation Database: DAG1
Human Genome Epidemiology Navigator: DAG1 (2 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/130 PubMed articles for DAG1 gene (see all 130 ):

Human dystroglycan: skeletal muscle cDNA, genomic structure, origin of tissue specific isoforms and chromosomal localization. (PubMed id 8268918)^{1, 3, 4} Ibraghimov-Beskrovnaya O.... Campbell K.P. (1993)
hAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan. (PubMed id 12592373)^{3, 4} Fletcher G.C....Terrett J.A. (2003)
Structure of a WW domain containing fragment of dystrophin in complex with beta-dystroglycan. (PubMed id 10932245)^{3, 4} Huang X.... Eck M.J. (2000)
Genetic mapping of the mouse neuromuscular mutation kyphoscoliosis. (PubMed id 7774920)^{2, 3} Skynner M.J....Blanco G. (1995)
Primary structure of dystrophin-associated glycoproteins linking dystrophin to the extracellular matrix. (PubMed id 1741056)^{2, 3} Ibraghimov-Beskrovnaya O....Campbell K.P. (1992)
Altered glycosylation of alpha-dystroglycan in neurons of Fukuyama congenital muscular dystrophy brains. (PubMed id 16466646)^{1, 3} Saito Y....Osawa M. (2006)
O Mannosylation of alpha-dystroglycan is essential for lymphocytic choriomeningitis virus receptor function. (PubMed id 16254364)^{1, 3} Imperiali M....Oxenius A. (2005)
Dystroglycan expression is frequently reduced in human breast and colon cancers and is associated with tumor progression. (PubMed id 12598319)^{1, 3} Sgambato A....Cittadini A. (2003)
Nuclear translocation of beta-dystroglycan reveals a distinctive trafficking pattern of autoproteolyzed mucins. (PubMed id 18764929)^{1, 3} Oppizzi M.L....Muschler J.L. (2008)
Altered expression of alpha-dystroglycan subunit in human gliomas. (PubMed id 16575202)^{1, 3} Calogero A....Petrucci T.C. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1605	HGNC: 2666	AceView: DAG1	Ensembl:ENSG00000173402	euGenes: HUgn1605
ECgene: DAG1	H-InvDB: DAG1

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
LEIDEN Muscular Dystrophy page for DAG1	Scientfic Information about Duchenne and Duchenne-like muscular dystrophies.
Wikipedia	http://en.wikipedia.org/wiki/Dystroglycan

Licensable Technologies for DAG1
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for DAG1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DAG1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DAG1		Antibodies for DAG1
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	Lentivirus-delivered shRNAs for DAG1		Browse small molecules at Sigma-Aldrich
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	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (DAG1)
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	Chimera RNAi (DAG1)
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	Recombinant Proteins (beta Dystroglycan, Alpha Dystroglycan)
	Antibodies (beta Dystroglycan, Alpha Dystroglycan)

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Antibodies for DAG1

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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DAG1 Gene at Home site.
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DAG1 Gene

protein-coding GIFtS: 66

Aliases &
Descriptions
for DAG1

Summaries
for DAG1

Genomic Location
for DAG1

Proteins
for DAG1

Protein Domains/
Families
for DAG1

Gene Function
for DAG1

Pathways & Interactions
for DAG1

Drugs & Compounds
for DAG1

Transcripts
for DAG1

Expression
for DAG1

Orthologs
for DAG1

Paralogs
for DAG1

SNPs/Variants
for DAG1

Disorders & Mutations
for DAG1

Medical News
for DAG1

Publications
for DAG1

Search for DAG1

Genome Databases showing DAG1

Other Databases showing DAG1

Specialized Databases showing DAG1

Licensable Technologies
for DAG1

Services
for DAG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DAG1 Gene

protein-coding GIFtS: 66

Aliases & Descriptionsfor DAG1

Summariesfor DAG1

Genomic Locationfor DAG1

Proteinsfor DAG1

Protein Domains/Familiesfor DAG1

Gene Functionfor DAG1

Pathways & Interactionsfor DAG1

Drugs & Compoundsfor DAG1

Transcriptsfor DAG1

Expression for DAG1

Orthologsfor DAG1

Paralogsfor DAG1

SNPs/Variantsfor DAG1

Disorders & Mutationsfor DAG1

Medical Newsfor DAG1

Publicationsfor DAG1

Search for DAG1

Genome Databases showing DAG1

Other Databases showing DAG1

Specialized Databases showing DAG1

Licensable Technologiesfor DAG1

Servicesfor DAG1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DAG1

Summaries
for DAG1

Genomic Location
for DAG1

Proteins
for DAG1

Protein Domains/
Families
for DAG1

Gene Function
for DAG1

Pathways & Interactions
for DAG1

Drugs & Compounds
for DAG1

Transcripts
for DAG1

Expression
for DAG1

Orthologs
for DAG1

Paralogs
for DAG1

SNPs/Variants
for DAG1

Disorders & Mutations
for DAG1

Medical News
for DAG1

Publications
for DAG1

Licensable Technologies
for DAG1

Services
for DAG1