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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAD1 Gene

protein-coding   GIFtS: 64
GCID: GC14M023033

defender against cell death 1
 Explore 13 diseases affiliated with
DAD1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DAD1    

Aliases
for DAD1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Defender Against Cell Death 11 2 3     Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit DAD12
OST21 2     Oligosaccharyltransferase 2 Homolog2
Oligosaccharyl Transferase Subunit DAD12 3     EC 2.4.99.183
DAD-12 3     EC 2.4.1.1198

External Ids:    HGNC: 26641   Entrez Gene: 16032   Ensembl: ENSG000001295627   OMIM: 6002435   UniProtKB: P618033   

Export aliases for DAD1 gene to outside databases

Previous GC identifers: GC14M020406 GC14M016821 GC14M021023 GC14M022103 GC14M003152


Summaries
for DAD1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DAD1:
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell
death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells
following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1
is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the
purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. (provided by RefSeq,
Jul 2008)

UniProtKB/Swiss-Prot: DAD1_HUMAN, P61803
Function: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high
mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr
consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates
with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the
endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis (By similarity)

Gene Wiki entry for DAD1


Genomic Views
for DAD1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAD1 gene promoter:
         TBP   Sp1   p53   Pax-2   Pax-2a   POU3F2   CREB   Pax-2b   deltaCREB   GCNF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DAD1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DAD1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAD1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q11.2   Ensembl cytogenetic band:  14q11.2   HGNC cytogenetic band: 14q11.2

DAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAD1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M023033:  view genomic region     (about GC identifiers)

Start:
 23,033,805 bp from pter      End:
 23,058,175 bp from pter
Size:
 24,371 bases      Orientation:
 minus strand

Proteins
for DAD1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DAD1_HUMAN, P61803 (See protein sequence)
Recommended Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1  
Size: 113 amino acids; 12497 Da
Subunit: Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain
at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the
Sec61 complex or with both the Sec61 and TRAP complexes (By similarity)
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
Secondary accessions: D3DS25 O08552 O70364 P46966 P46968 Q6FGA3 Q96GB7

Explore the universe of human proteins at neXtProt for DAD1: NX_P61803

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P61803

    • 4 DME Specific Peptides for DAD1 (P61803)
     LTGALQFGYCL  SVISRFLEEYLS  FQGISPERAFADFLFA  YCLLVGTFPFNSFLSGFIS 

    DAD1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_001335.1  
    ENSEMBL proteins: 
     ENSP00000250498   ENSP00000442074   ENSP00000440242   ENSP00000440821  
    Reactome Protein details: P61803
    Human Recombinant Protein Products: 
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    Uscn Proteins for DAD1

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0008250oligosaccharyltransferase complex TAS15835887
    GO:0016021integral to membrane IEA--


    DAD1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DAD1

    Protein Domains /
    Families
    for DAD1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DAD1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR003038 DAD/Ost2

    Graphical View of Domain Structure for InterPro Entry P61803

    ProtoNet protein and cluster: P61803

    UniProtKB/Swiss-Prot: DAD1_HUMAN, P61803
    Similarity: Belongs to the DAD/OST2 family


    Function
    for DAD1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DAD1_HUMAN, P61803
    Function: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high
    mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr
    consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates
    with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the
    endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis (By similarity)
    Catalytic activity: Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein
    with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine

         Genatlas biochemistry entry for DAD1:
    defender against apoptosis

    Enzyme Numbers (IUBMB): EC 2.4.1.1192 EC 2.4.99.181

    miRNA
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    Inhib. RNA
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    OriGene shRNA RFP: DAD1
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    Gene Editing
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    Clone
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    Cell Line
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    Search LifeMap BioReagents cell lines for DAD1

    In Situ Assay
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004576contributes to oligosaccharyl transferase activity ISS--
    GO:0004579contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity IC15835887


    DAD1 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DAD1:
     Increased cell number in S 

    Animal Models:
         Mouse knock-outs for DAD1: Dad1tm1Brw Dad1tm1Wnt Dad1tm1Kni
         7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dad1):
     cellular  embryogenesis  growth/size  hematopoietic system  immune system 
     limbs/digits/tail  mortality/aging 

    DAD1 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DAD1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways  About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Asparagine N-linked glycosylation
    		Asparagine N-linked glycosylation1.00
    		Post-translational protein modification0.44
    		N-Glycan biosynthesis0.52
    		Metabolism of proteins0.15
    2Protein processing in endoplasmic reticulum
    		Protein processing in endoplasmic reticulum1.00
    3Metabolism
    		Metabolic pathways0.38
    4Mechanisms of CFTR activation by S-nitrosoglutathione (normal and CF)
    		CFTR folding and maturation (norm and CF)0.37

    Pathway sources
    See GeneCards unified pathways
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for DAD1
        CFTR folding and maturation (norm and CF)

    3        Reactome Pathways for DAD1
        Asparagine N-linked glycosylation
    Metabolism of proteins
    Post-translational protein modification


    3         Kegg Pathways  (Kegg details for DAD1):
        N-Glycan biosynthesis
    Metabolic pathways
    Protein processing in endoplasmic reticulum

    UniProtKB/Swiss-Prot: DAD1_HUMAN, P61803
    Pathway: Protein modification; protein glycosylation


    DAD1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAD1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 23)

    5/30 Interacting proteins for DAD1 (P618033 ENSP000002504984) via UniProtKB, MINT, STRING, and/or I2D (see all 30)

    InteractantInteraction Details
    GeneCardExternal ID(s)
    MCL1Q078203, ENSP000003580224I2D: score=3 STRING: ENSP00000358022
    EPB41P111713, ENSP000002901004I2D: score=1 STRING: ENSP00000290100
    TUBG1P232583I2D: score=5 
    ATG5Q9H1Y03I2D: score=1 
    HLA-BP304803I2D: score=1 
    About this table

    Gene Ontology (GO): 5/9 biological process terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001824blastocyst development IEA--
    GO:0006486protein glycosylation ISS--
    GO:0006915apoptotic process IEA--
    GO:0007584response to nutrient IEA--
    GO:0018279protein N-linked glycosylation via asparagine TAS--


    DAD1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DAD1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
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    Browse Tocris compounds for DAD1

    2 HMDB Compounds for DAD1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Dolichyl diphosphateDolichyl diphosphate (see all 2)37247-98-6--
    L-Asparagine(-)-Asparagine (see all 32)70-47-3--
    Search CenterWatch for drugs/clinical trials and news about DAD1 

    Transcripts
    for DAD1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DAD1 gene: 
    NM_001344.2  

    Unigene Cluster for DAD1:

    Defender against cell death 1
    Hs.82890  [show with all ESTs]
    Unigene Representative Sequence: BF697316
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000250498(uc001wgl.2) ENST00000489532 ENST00000535847 ENST00000538631
    ENST00000543337 ENST00000479564

    miRNA
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    Inhib. RNA
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    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAD1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAD1

    Additional cDNA sequence: 

    AK223129.1 BC007403.2 BC009798.1 BC038575.1 CR407682.1 CR542204.1 D15057.1 

    14 DOTS entries:

    DT.100888251  DT.429755  DT.92450253  DT.92450280  DT.120746489  DT.95112068  DT.100888242  DT.91730842 
    DT.95112072  DT.92450252  DT.92450281  DT.40130038  DT.86859396  DT.95296965 

    24/334 AceView cDNA sequences (see all 334):

    CR593103 AI270037 AA345135 BQ644712 AA321526 CA422002 D57150 AI088579 
    BG285584 CD678608 CR407682 BG105475 CR542204 BX283525 AA736454 BX281531 
    BM773447 AA382956 AA446415 BU928037 AA641676 BU943396 BG505692 BU601908 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for DAD1    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
    SP1:                                            -                           
    SP2:                                      -     -                           
    SP3:                    -                 -     -                           
    SP4:                                                                        
    SP5:                          -     -     -     -                           


    ECgene alternative splicing isoforms for DAD1

    Expression
    for DAD1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAD1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CCACTCCTCA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DAD1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BoneEndochondral Facial BonesBone
    BoneStylopod Long BoneBone
    BoneThoracic RibBone
    BoneZeugopod Long BoneBone
    CartilageMeckel's CartilageCartilage
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DAD1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAD1

    SOURCE GeneReport for Unigene cluster: Hs.82890
        SABiosciences Expression via Pathway-Focused PCR Arrays including DAD1: 
              Apoptosis 384HT in human mouse rat
              Apoptosis in human mouse rat

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    In Situ
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    Orthologs
    for DAD1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of eukaryotes.

    Orthologs for DAD1 gene from 9/30 species (see all 30)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dad11 , 5 defender against cell death 11, 5 91.45(n)1
    100(a)1    		   14 (27.70 cM)5
    131351  NM_001113358.11  NP_001106829.11 
     542354795 
    chicken
    (Gallus gallus)    		 Aves DAD11 defender against cell death 1 74.7(n)
    82.14(a)    		   395343  NM_001007473.1  NP_001007474.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DAD16
    		 --
    		 76(a)
    		 1 ↔ 1
    		 GL343979.1(72177-75771)
    African clawed frog
    (Xenopus laevis)    		 Amphibia LOC3977212 DAD-1 76.01(n)    D15059.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dad11 defender against cell death 1 70.5(n)
    83.19(a)    		   566527  NM_001100439.1  NP_001093909.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG133931 , 3 anti-apoptosis oligosaccharyl transferase3
    CG133931    		 71(a)3
    63.55(n)1
    71.96(a)1    		   29B43
    341591  NM_135378.31  NP_609222.11 
    worm
    (Caenorhabditis elegans)    		 Secernentea dad-11 , 3 Protein DAD-11 61(a)3
    61.65(n)1
    61.95(a)1    		   I(6561574-6562591)3
    1723701  NM_059488.51  NP_491889.11 
    thale cress
    (Arabidopsis thaliana)    		 eudicotyledons ATDAD11 dolichyl-diphosphooligosaccharide--protein glycosyltransferase more 55.56(n)
    52.94(a)    		   840113  NM_102954.3  NP_174500.1 
    rice
    (Oryza sativa)    		 Liliopsida Os04g03970001 hypothetical protein 54.65(n)
    47.75(a)    		   4335701  NM_001059199.1  NP_001052664.1 


    ENSEMBL Gene Tree for DAD1 (if available)
    TreeFam Gene Tree for DAD1 (if available) 

    Paralogs
    for DAD1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DAD1 gene

    DAD1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for DAD1
    PGOHUM00000239371


    Genomic Variants
    for DAD1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/628 NCBI SNPs in DAD1 are shown (see all 628)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs57428781,2
    		C,F,H,--23033390(-) TATGTG/TTTGAC 1 -- ds500118Minor allele frequency- T:0.11NS EA NA WA 1254
    rs20622751,2
    		C,F,A,H,--23033425(+) CTACAT/CTGCCT 1 -- ds500124Minor allele frequency- C:0.26NS EA NA WA CSA 1070
    rs57428771,2
    		C,F,H,--23033454(-) TAGTGG/TTAAAA 1 -- ds50015Minor allele frequency- T:0.00NS EA 590
    rs57428761,2
    		C,F,H,--23033488(-) GTGCTA/TCCACA 1 -- ds500112Minor allele frequency- T:0.11NS EA NA WA 830
    rs57428751,2
    		C,F,H,--23033543(-) AGTGCA/GTTCCT 1 -- ds500127Minor allele frequency- G:0.13NS EA NA WA 2806
    rs57428741,2
    		C,F,H,--23033608(-) TCTTCC/GTGGAG 1 -- ds50016Minor allele frequency- G:0.02NS EA NA 718
    rs1809631631,2
    		--23033617(+) GAAGAC/TAAAGG 1 -- ds50010--------
    rs57428731,2
    		C,F,H,--23033652(-) AAAAGG/ACAGTG 1 -- ds50016Minor allele frequency- A:0.04NS EA WA 718
    rs20668201,2
    		C,F,A,H,--23033776(-) TCTTTG/ACTGGT 1 -- ds500123Minor allele frequency- A:0.14NA NS EA WA 2496
    rs1863836151,2
    		--23033832(+) TTAATC/TTGGAA 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DAD1 (23033805 - 23058175 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DAD1
         1 Indel: 49324

    SABiosciences Cancer Mutation PCR Assays
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    Disorders / Diseases
    for DAD1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DAD1 for disorders           About GeneDecksing

    OMIM gene information: 600243    OMIM disorders: --

    13 diseases for DAD1:    About MalaCards
    anaplastic large cell lymphoma    papillary thyroid carcinoma    folliculitis    carcinoid tumors
    thyroid carcinoma    parkinson's disease    thyroiditis    hepatocellular carcinoma
    lung cancer    carcinoma    esophagitis    adenocarcinoma
    prostatitis

    1 disease from the University of Copenhagen DISEASES database for DAD1:
    Schizophrenia

    1 Novoseek disease relationship for DAD1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    tumors 0 1 18383209 (1)

    Human Genome Epidemiology (HuGE) Navigator: DAD1 (5 documents)

    Export disorders for DAD1 gene to outside databases

    Publications
    for DAD1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAD1 gene, integrated from 9 sources (see all 48):
    (articles sorted by number of sources associating them with DAD1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. (PubMed id 8413235)1, 2, 9 Nakashima T.... Nishimoto T. (1993)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    3. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    4. The highly conserved defender against the death 1 (DAD1) gene maps to human chromosome 14q11-q12 and mouse chromosome 14 and has plant and nematode homologs. (PubMed id 7737422)1, 9 Apte S.S....Olsen B.R. (1995)
    5. The DAD1 protein, whose defect causes apoptotic cell death, maps to human chromosome 14. (PubMed id 7601483)1, 9 Yulug I.G....Ylug I.G. (1995)
    6. High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. (PubMed id 18383209)1, 9 Kulke M.H....Shivdasani R.A. (2008)
    7. An important role for CDK2 in G1 to S checkpoint activation and DNA damage response in human embryonic stem cells. (PubMed id 21319273)1 Neganova I....Lako M. (2011)
    8. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    9. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    10. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)

    External Searches for DAD1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
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    Genome Databases showing DAD1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1603 HGNC: 2664 AceView: DAD1 Ensembl:ENSG00000129562 euGenes: HUgn1603
    ECgene: DAD1 Kegg: 1603 H-InvDB: DAD1

    Other Databases showing DAD1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DAD1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAD1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DAD1 Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPshttp://egp.gs.washington.edu/data/dad1/

    Intellectual Property
    for DAD1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DAD1 gene:
    Search GeneIP for patents involving DAD1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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