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Aliases for DAD1 Gene

Aliases for DAD1 Gene

  • Defender Against Cell Death 1 2 3 4 5
  • Oligosaccharyltransferase Subunit 2 (Non-Catalytic) 2 3
  • Oligosaccharyl Transferase Subunit DAD1 3 4
  • DAD-1 3 4
  • Dolichyl-Diphosphooligosaccharide--Protein Glycosyltransferase Subunit DAD1 3
  • Oligosaccharyltransferase 2 Homolog (S. Cerevisiae) 2
  • Oligosaccharyltransferase 2 Homolog 3
  • EC 2.4.1.119 61
  • EC 2.4.99.18 4
  • OST2 3

External Ids for DAD1 Gene

Previous GeneCards Identifiers for DAD1 Gene

  • GC14M020406
  • GC14M016821
  • GC14M021023
  • GC14M022103
  • GC14M023033
  • GC14M003152

Summaries for DAD1 Gene

Entrez Gene Summary for DAD1 Gene

  • DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by RefSeq, Jul 2008]

GeneCards Summary for DAD1 Gene

DAD1 (Defender Against Cell Death 1) is a Protein Coding gene. Among its related pathways are Transport to the Golgi and subsequent modification and Metabolism of proteins. GO annotations related to this gene include dolichyl-diphosphooligosaccharide-protein glycotransferase activity and oligosaccharyl transferase activity.

UniProtKB/Swiss-Prot for DAD1 Gene

  • Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis (By similarity).

Gene Wiki entry for DAD1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAD1 Gene

Genomics for DAD1 Gene

Regulatory Elements for DAD1 Gene

Enhancers for DAD1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F022504 1.7 FANTOM5 Ensembl ENCODE 19.2 +51.1 51082 66.7 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF548 MMP14 ABHD4 OXA1L LOC105370399 EFS HOMEZ C14orf119 DAD1 ENSG00000258457 TRAV37
GH14F022571 0.7 ENCODE 18.8 +16.6 16601 1.7 ARID4B DNMT3B RARA ZNF207 FOS CREM HMG20B PPARG KAT8 PPARGC1A DAD1 OR6J1 ABHD4 MMP14 OXA1L MRPL52 SLC7A7 PRMT5 C14orf93 LOC105370400
GH14F022587 0.9 FANTOM5 ENCODE 15 +0.2 196 3.2 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MMP14 OXA1L DAD1 ABHD4 OR6J1 BCL2L2 HOMEZ LRP10 REM2 LOC105370400
GH14F022844 1.1 FANTOM5 ENCODE 10.6 -260.0 -260013 9.9 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 OXA1L LRP10 REM2 PPP1R3E RBM23 THTPA DAD1 HOMEZ PABPN1 HAUS4
GH14F022854 0.6 ENCODE 10.6 -266.0 -265991 1.3 ELF3 SAP130 RARA ZKSCAN1 SLC30A9 PRDM10 NFE2 FOS MAFK NFE2L2 SLC7A7 MRPL52 REM2 OXA1L DAD1 OR6J1 HAUS4 ENSG00000212335 GC14M022854 GC14P023836
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DAD1 on UCSC Golden Path with GeneCards custom track

Promoters for DAD1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000096841 69 2001 MLX CREB3L1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3

Genomic Location for DAD1 Gene

Chromosome:
14
Start:
22,564,905 bp from pter
End:
22,589,269 bp from pter
Size:
24,365 bases
Orientation:
Minus strand

Genomic View for DAD1 Gene

Genes around DAD1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAD1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAD1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAD1 Gene

Proteins for DAD1 Gene

  • Protein details for DAD1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P61803-DAD1_HUMAN
    Recommended name:
    Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1
    Protein Accession:
    P61803
    Secondary Accessions:
    • D3DS25
    • O08552
    • O70364
    • P46966
    • P46968
    • Q6FGA3
    • Q96GB7

    Protein attributes for DAD1 Gene

    Size:
    113 amino acids
    Molecular mass:
    12497 Da
    Quaternary structure:
    • Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By similarity).

neXtProt entry for DAD1 Gene

Selected DME Specific Peptides for DAD1 Gene

Post-translational modifications for DAD1 Gene

  • Ubiquitination at Lys 82
  • Modification sites at PhosphoSitePlus

Other Protein References for DAD1 Gene

Domains & Families for DAD1 Gene

Gene Families for DAD1 Gene

Protein Domains for DAD1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DAD1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P61803

UniProtKB/Swiss-Prot:

DAD1_HUMAN :
  • Belongs to the DAD/OST2 family.
Family:
  • Belongs to the DAD/OST2 family.
genes like me logo Genes that share domains with DAD1: view

Function for DAD1 Gene

Molecular function for DAD1 Gene

GENATLAS Biochemistry:
defender against apoptosis
UniProtKB/Swiss-Prot CatalyticActivity:
Dolichyl diphosphooligosaccharide + [protein]-L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by N-beta-D-glycosyl linkage to a protein L-asparagine.
UniProtKB/Swiss-Prot Function:
Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss of the DAD1 protein triggers apoptosis (By similarity).

Enzyme Numbers (IUBMB) for DAD1 Gene

Gene Ontology (GO) - Molecular Function for DAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004576 contributes_to oligosaccharyl transferase activity ISS --
GO:0004579 contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity IEA,IC 15835887
GO:0016740 transferase activity IEA --
GO:0016757 transferase activity, transferring glycosyl groups IEA --
genes like me logo Genes that share ontologies with DAD1: view
genes like me logo Genes that share phenotypes with DAD1: view

Animal Models for DAD1 Gene

MGI Knock Outs for DAD1:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAD1 Gene

Localization for DAD1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAD1 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAD1 Gene COMPARTMENTS Subcellular localization image for DAD1 gene
Compartment Confidence
endoplasmic reticulum 5
extracellular 5
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for DAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,TAS --
GO:0008250 oligosaccharyltransferase complex IEA,TAS 15835887
GO:0016020 membrane IEA,IDA 19946888
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with DAD1: view

Pathways & Interactions for DAD1 Gene

genes like me logo Genes that share pathways with DAD1: view

Pathways by source for DAD1 Gene

UniProtKB/Swiss-Prot P61803-DAD1_HUMAN

  • Pathway: Protein modification; protein glycosylation.

Gene Ontology (GO) - Biological Process for DAD1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001824 blastocyst development IEA --
GO:0006486 protein glycosylation IEA,ISS --
GO:0006487 protein N-linked glycosylation IBA --
GO:0006915 apoptotic process IEA --
GO:0007584 response to nutrient IEA --
genes like me logo Genes that share ontologies with DAD1: view

No data available for SIGNOR curated interactions for DAD1 Gene

Drugs & Compounds for DAD1 Gene

(1) Drugs for DAD1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
L-Asparagine Approved Nutra 0

(1) Additional Compounds for DAD1 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Dolichyl diphosphate
  • Dolichyl diphosphate
37247-98-6
genes like me logo Genes that share compounds with DAD1: view

Transcripts for DAD1 Gene

Unigene Clusters for DAD1 Gene

Defender against cell death 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAD1 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2a · 2b ^ 3 ^ 4 ^ 5a · 5b · 5c · 5d
SP1: -
SP2: - -
SP3: - - -
SP4:
SP5: - - - -

Relevant External Links for DAD1 Gene

GeneLoc Exon Structure for
DAD1
ECgene alternative splicing isoforms for
DAD1

Expression for DAD1 Gene

mRNA expression in normal human tissues for DAD1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DAD1 Gene

This gene is overexpressed in Nasal epithelium (32.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DAD1 Gene



Protein tissue co-expression partners for DAD1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of DAD1 Gene:

DAD1

SOURCE GeneReport for Unigene cluster for DAD1 Gene:

Hs.82890
genes like me logo Genes that share expression patterns with DAD1: view

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DAD1 Gene

Orthologs for DAD1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DAD1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAD1 34 35
  • 99.71 (n)
dog
(Canis familiaris)
Mammalia DAD1 34 35
  • 93.51 (n)
cow
(Bos Taurus)
Mammalia DAD1 34 35
  • 92.33 (n)
mouse
(Mus musculus)
Mammalia Dad1 34 16 35
  • 91.45 (n)
rat
(Rattus norvegicus)
Mammalia Dad1 34
  • 90.27 (n)
oppossum
(Monodelphis domestica)
Mammalia DAD1 35
  • 77 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAD1 34 35
  • 74.7 (n)
lizard
(Anolis carolinensis)
Reptilia DAD1 35
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dad1 34
  • 75.52 (n)
Str.10052 34
African clawed frog
(Xenopus laevis)
Amphibia LOC397721 34
zebrafish
(Danio rerio)
Actinopterygii dad1 34 35
  • 70.5 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13393 36
  • 71 (a)
l(2)k12914 34 35
  • 63.55 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008491 34
  • 63.06 (n)
worm
(Caenorhabditis elegans)
Secernentea dad-1 36 34 35
  • 61.65 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes OST2 35 37
  • 34 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons ATDAD1 34
  • 55.56 (n)
rice
(Oryza sativa)
Liliopsida Os04g0397000 34
  • 56.67 (n)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.5446 35
  • 63 (a)
OneToOne
Species where no ortholog for DAD1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAD1 Gene

ENSEMBL:
Gene Tree for DAD1 (if available)
TreeFam:
Gene Tree for DAD1 (if available)

Paralogs for DAD1 Gene

Pseudogenes.org Pseudogenes for DAD1 Gene

genes like me logo Genes that share paralogs with DAD1: view

No data available for Paralogs for DAD1 Gene

Variants for DAD1 Gene

Sequence variations from dbSNP and Humsavar for DAD1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10133489 -- 22,569,448(+) aaaaa(A/G)GTTTA intron-variant
rs10137999 -- 22,578,899(+) TCTTA(C/T)CTGCT intron-variant
rs10141773 -- 22,582,132(+) aactc(C/T)aaggg intron-variant
rs10145349 -- 22,583,472(+) agtag(C/T)gagga intron-variant
rs10145997 -- 22,578,966(+) GGTCC(A/G)GGCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAD1 Gene

Variant ID Type Subtype PubMed ID
esv2678511 CNV deletion 23128226
esv3633757 CNV loss 21293372
esv3892469 CNV gain+loss 25118596
nsv1047315 CNV gain 25217958
nsv519534 CNV loss 19592680
nsv563998 CNV gain 21841781
nsv832746 CNV gain 17160897
nsv832748 CNV gain 17160897

Variation tolerance for DAD1 Gene

Residual Variation Intolerance Score: 48.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.15; 3.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAD1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAD1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAD1 Gene

Disorders for DAD1 Gene

Relevant External Links for DAD1

Genetic Association Database (GAD)
DAD1
Human Genome Epidemiology (HuGE) Navigator
DAD1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAD1

No disorders were found for DAD1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DAD1 Gene

Publications for DAD1 Gene

  1. Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. (PMID: 8413235) Nakashima T. … Nishimoto T. (Mol. Cell. Biol. 1993) 3 4 22 64
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  3. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PMID: 20453000) Liu C.Y. … Christiani D.C. (Carcinogenesis 2010) 3 46 64
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 46 64
  5. High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. (PMID: 18383209) Kulke M.H. … Shivdasani R.A. (Genes Chromosomes Cancer 2008) 3 22 64

Products for DAD1 Gene

Sources for DAD1 Gene

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