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DAD1 Gene

protein-coding GIFtS: 62

GC14M022103

defender against cell death 1
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DAD-1 ^³
EC 2.4.1.119 ^³
OST2 ^¹, ²

Descriptions
Oligosaccharyl transferase subunit DAD1 ^³
defender against cell death 1 ^², ³

External Ids
HGNC: 2664¹
Entrez Gene: 1603²
UniProtKB: P61803³
Ensembl: ENSG00000129562⁷

Search outside databases for aliases for DAD1 gene

Previous GC identifers: GC14M020406 GC14M016821 GC14M021023

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DAD1:

DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator

of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein

disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature,

suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly

associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified

enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. [provided by

RefSeq]

UniProtKB/Swiss-Prot: DAD1_HUMAN, P61803

Function: Component of the N-oligosaccharyl transferase enzyme which catalyzes the transfer of a

high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue

within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs

cotranslationally and the complex associates with the Sec61 complex at the channel-forming

translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss

of the DAD1 protein triggers apoptosis (By similarity)

Gene Wiki entry for DAD1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DAD1 gene

Entrez Gene cytogenetic band: 14q11-q12 Ensembl cytogenetic band: 14q11.2 HGNC cytogenetic band: 14q11.2

DAD1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14M022103: (about GC identifiers)

Start:	22,103,647 bp from pter
End:	22,127,970 bp from pter
Size:	24,324 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000014.7 NT_026437.11

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: DAD1_HUMAN, P61803 (See protein sequence)

Recommended Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1

Size: 113 amino acids; 12497 Da

Subunit: Component of the oligosaccharyltransferase (OST) complex. OST seems to exist in different

forms which contain at least RPN1, RPN2, OST48, DAD1, OSTC, KRTCAP2 and either STT3A or STT3B. OST

can form stable complexes with the Sec61 complex or with both the Sec61 and TRAP complexes (By

similarity)

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: O08552 O70364 P46966 P46968 Q6FGA3 Q96GB7

REFSEQ proteins: NP_001335.1

ENSEMBL proteins:

ENSP00000250498

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DAD1)
	Human Recombinant Proteins from Abnova (DAD1)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008250	oligosaccharyltransferase complex	TAS	15835887
GO:0016020	membrane	IEA	--
GO:0016021	integral to membrane	IEA	--

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Antibodies for DAD1:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for DAD1
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (DAD1), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DAD1)
	Novus Biologicals Antibodies for DAD1

Assays for DAD1:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P61803

ProtoNet protein and cluster: P61803

UniProtKB/Swiss-Prot: DAD1_HUMAN, P61803

Similarity: Belongs to the DAD/OST2 family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAD1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DAD1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001344

Applied Biosystems Silencer® siRNAs for DAD1

Sigma-Aldrich siRNA and siRNA Panels for DAD1

Sigma-Aldrich shRNA for DAD1

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DAD1
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001344
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001344
untagged cDNA clone in CMV expression vector: NM_001344

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001344

UniProtKB/Swiss-Prot: DAD1_HUMAN, P61803

Function: Component of the N-oligosaccharyl transferase enzyme which catalyzes the transfer of a

high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue

within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. N-glycosylation occurs

cotranslationally and the complex associates with the Sec61 complex at the channel-forming

translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). Loss

of the DAD1 protein triggers apoptosis (By similarity)

Catalytic activity: Dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate

+ a glycoprotein with the oligosaccharide chain attached by N-glycosyl linkage to protein

L-asparagine

Enzyme Number (IUBMB): EC 2.4.1.119

Genatlas biochemistry entry for DAD1:

defender against apoptosis

7 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dad1):

cellular	embryogenesis	growth/size	hematopoietic system	immune system
lethality-prenatal/perinatal	limbs/digits/tail

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004579	contributes to dolichyl-diphosphooligosaccharide-protein glycotransferase activity	IC	15835887
GO:0016740	transferase activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for DAD1 (Your Favorite Gene powered by Ingenuity)

N-Glycan Biosynthesis

GeneDecks DAD1 for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for DAD1

5/38 Interacting proteins for DAD1 (ENSP00000250498³) via UniProtKB, MINT, and/or STRING (see all 38 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DDOST	ENSP00000364188³	STRING (score=.982)
RPN2	ENSP00000345904³	STRING (score=.98)
RPN1	ENSP00000296255³	STRING (score=.978)
STT3B	ENSP00000295770³	STRING (score=.962)
SEC61A1	ENSP00000243253³	STRING (score=.961)

About this table

4 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001824	blastocyst development	IEA	--
GO:0006915	apoptosis	IEA	--
GO:0006916	anti-apoptosis	TAS	8413235
GO:0018279	protein amino acid N-linked glycosylation via asparagine	IC	15835887

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DAD1

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAD1)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (DAD1)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001344

Sigma-Aldrich siRNA and siRNA Panels for DAD1

Sigma-Aldrich shRNA for DAD1

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001344

REFSEQ mRNAs for DAD1 gene:

NM_001344.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001344

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001344
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001344
                                 untagged cDNA clone in CMV expression vector: NM_001344

Additional cDNA sequence:

AK223129.1 BC007403.2 BC009798.1 BC038575.1 CR407682.1 CR542204.1 CR593103.1 D15057.1

15 DOTS entries:

DT.100888251 DT.429755 DT.92450253 DT.92450280 DT.120746489 DT.95112068 DT.100888242 DT.91730842

DT.95112072 DT.92450281 DT.40130038 DT.426326 DT.86859396 DT.92450252 DT.95296965

24/334 AceView cDNA sequences (see all 334 ):

AA321526 BG105475 BX283525 BQ644712 CR542204 CD678608 CA422002 CR593103

BG285584 BM773447 AA345135 D57150 AA382956 AA446415 AI088579 CR407682

AI270037 AA736454 BX281531 AV695781 CB128795 BG611693 BQ637502 BG167397

highest scoring ESTs for DAD1:

D15057 AA046891 AA095795 AA216141 AA299316 AA317258 AA319651 AA321526 AA352060 AA352248

Unigene Cluster for DAD1:

Defender against cell death 1

Hs.82890 [show with all ESTs]

Unigene Representative Sequence: BF697316

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for DAD1

ExUns:	1a	·	1b	·	1c	·	1d	^	2a	·	2b	^	3	^	4	^	5a	·	5b	·	5c	·	5d
SP1:															-
SP2:													-		-
SP3:							-						-		-
SP4:
SP5:									-		-		-		-

About this scheme

ECgene alternative splicing isoforms for DAD1

1 Ensembl transcript including schematic representation:

ENST00000250498

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DAD1 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DAD1

¹ / ² / ³

3 probe-sets matching DAD1 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
38413_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	D15057	1.00	1.00	1.00	1
200046_at²^{, 3}	U133-B	1	1.00	1.00	--	--	NM_001344	0.60	1.00	0.82	1
200046_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CCACTCCTCA

SOURCE GeneReport for Unigene cluster: Hs.82890
Expression variation in blood from EXPOLDB for DAD1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DAD1 gene from 5/18 species (see all 18 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DAD1¹	--	defender against cell death 1	93.51(n) 99.12(a)	480238 XM_537361.2 XP_537361.2
chimpanzee (Pan troglodytes)	DAD1¹	--	defender against cell death 1	99.71(n) 100(a)	452783 XM_509838.2 XP_509838.2
cow (Bos taurus)	DAD1¹	--	defender against cell death 1	92.33(n) 98.23(a)	614538 NM_001034761.1 NP_001029933.1
rat (Rattus norvegicus)	Dad1¹	--	defender against cell death 1	90.27(n) 100(a)	192275 NM_138910.2 NP_620265.1
mouse (Mus musculus)	Dad1^{1, 5}	14 (24.00 cM)⁵	defender against cell death 1^{1, 5}	91.45(n)¹ 100(a)¹	13135¹ NM_010015.3¹ NP_034145.1¹ AA050703⁵ AF000941⁵ (see all 26)

About this table Species with no ortholog for DAD1

ENSEMBL Gene Tree for DAD1

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/377 NCBI SNPs in DAD1 are shown (see all 377 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 175)

AB	SNP ID	Valid	Chr 14 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1803479^1,2	A,C,F,H,O	22103830(-)	`AGCTTA/GTTGGA`	1	--	ut3¹ ese³		13	NA NS EU EA WA	1230
--	rs1051101^1,2	A,C,F,H	22127924(-)	`CGGACC/TGGAGT`	1	--	ut5¹ ese³		14	EA NS EU WA NA	2322
	rs1051189^1,2	C,F,H,O	22103678(-)	`TTTGCC/TTTCCA`	1	--	ut3¹		17	NA EA NS EU WA	2848
	rs2066820^1,2	A,C,F,H	22103616(-)	`TCTTTG/ACTGGT`	1	--	ng5¹		8	NA NS EU EA WA	852
	rs2062275^1,2	A,C,F,H	22103265(+)	`CTACAT/CTGCCT`	1	--	ng5¹		11	EU EA WA NS	692
	rs5742725^1,2	C,F,H	22128625(-)	`CCCAAG/AGAGGC`	1	--	ng3¹		11	NS EU EA WA	990
	rs5742726^1,2	C,F,H	22128576(-)	`TTCCAG/CTTCAG`	1	--	ng3¹ tfbs³		5	NS EU EA WA	536
	rs5742875^1,2	C,F,H	22103383(-)	`AGTGCA/GTTCCT`	1	--	ng5¹		12	NS EU EA WA NA	1154
	rs5742878^1,2	C,F,H	22103230(-)	`TATGTG/TTTGAC`	1	--	ng5¹		9	NS EU EA WA	994
	rs5742874^1,2	F,H	22103448(-)	`TCTTCC/GTGGAG`	1	--	ng5¹		5	NS EU EA WA	598

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HapMap Linkage Disequilibrium images for DAD1 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 600243

1 Novoseek disease relationship for DAD1 gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
tumors	0.00	1	18383209 (1)

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1 PharmGKB disease relationship for DAD1 gene

Disease	PharmGKB Relations	PubMed IDs for articles supporting these relationships
Leukemia, Lymphocytic, Acute, L1	FA GN	12086872

About this table

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/38 PubMed articles for DAD1 gene (see all 38 ):

Molecular cloning of a human cDNA encoding a novel protein, DAD1, whose defect causes apoptotic cell death in hamster BHK21 cells. (PubMed id 8413235)^{1, 3, 4} Nakashima T.... Nishimoto T. (1993)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{3, 4} Gevaert K.... Vandekerckhove J. (2003)
The highly conserved defender against the death 1 (DAD1) gene maps to human chromosome 14q11-q12 and mouse chromosome 14 and has plant and nematode homologs. (PubMed id 7737422)^{1, 3} Apte S.S....Olsen B.R. (1995)
The DAD1 protein, whose defect causes apoptotic cell death, maps to human chromosome 14. (PubMed id 7601483)^{1, 3} Yulug I.G....Ylug I.G. (1995)
High-resolution analysis of genetic alterations in small bowel carcinoid tumors reveals areas of recurrent amplification and loss. (PubMed id 18383209)^{1, 3} Kulke M.H....Shivdasani R.A. (2008)
Proteomic analysis of mammalian oligosaccharyltransferase reveals multiple subcomplexes that contain Sec61, TRAP, and two potential new subunits. (PubMed id 15835887)³ Shibatani T.... Skach W.R. (2005)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)³ Suzuki Y.... Sugano S. (2004)
Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling. (PubMed id 12086872)⁷ Yeoh E.J....Downing J.R. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)³ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1603	HGNC: 2664	AceView: DAD1	Ensembl:ENSG00000129562	euGenes: HUgn1603
ECgene: DAD1	H-InvDB: DAD1

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for DAD1	Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs	http://egp.gs.washington.edu/data/dad1/

Licensable Technologies for DAD1
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for DAD1:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DAD1-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DAD1		Antibodies for DAD1
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DAD1		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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	Custom Service for Rabbit Pab from Full-length Protein

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Search Tocris compounds for DAD1

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Antibodies for DAD1

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DAD1 Gene

protein-coding GIFtS: 62

Aliases &
Descriptions
for DAD1

Summaries
for DAD1

Genomic Location
for DAD1

Proteins
for DAD1

Protein Domains/
Families
for DAD1

Gene Function
for DAD1

Pathways & Interactions
for DAD1

Drugs & Compounds
for DAD1

Transcripts
for DAD1

Expression
for DAD1

Orthologs
for DAD1

Paralogs
for DAD1

SNPs/Variants
for DAD1

Disorders & Mutations
for DAD1

Medical News
for DAD1

Publications
for DAD1

Search for DAD1

Genome Databases showing DAD1

Other Databases showing DAD1

Specialized Databases showing DAD1

Licensable Technologies
for DAD1

Services
for DAD1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DAD1 Gene

protein-coding GIFtS: 62

Aliases & Descriptionsfor DAD1

Summariesfor DAD1

Genomic Locationfor DAD1

Proteinsfor DAD1

Protein Domains/Familiesfor DAD1

Gene Functionfor DAD1

Pathways & Interactionsfor DAD1

Drugs & Compoundsfor DAD1

Transcriptsfor DAD1

Expression for DAD1

Orthologsfor DAD1

Paralogsfor DAD1

SNPs/Variantsfor DAD1

Disorders & Mutationsfor DAD1

Medical Newsfor DAD1

Publicationsfor DAD1

Search for DAD1

Genome Databases showing DAD1

Other Databases showing DAD1

Specialized Databases showing DAD1

Licensable Technologiesfor DAD1

Servicesfor DAD1

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DAD1

Summaries
for DAD1

Genomic Location
for DAD1

Proteins
for DAD1

Protein Domains/
Families
for DAD1

Gene Function
for DAD1

Pathways & Interactions
for DAD1

Drugs & Compounds
for DAD1

Transcripts
for DAD1

Expression
for DAD1

Orthologs
for DAD1

Paralogs
for DAD1

SNPs/Variants
for DAD1

Disorders & Mutations
for DAD1

Medical News
for DAD1

Publications
for DAD1

Licensable Technologies
for DAD1

Services
for DAD1