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DACT3 Gene

protein-coding   GIFtS: 46
GCID: GC19M047150

Dishevelled-Binding Antagonist Of Beta-Catenin 3

(Previous names: arginine rich region 1, dapper, antagonist of beta-catenin,...)
(Previous symbol: RRR1)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dishevelled-Binding Antagonist Of Beta-Catenin 31 2     Dapper Antagonist Of Catenin 32 3
RRR11 2 3     Dapper, Antagonist Of Beta-Catenin, Homolog 3 (Xenopus Laevis)1
Arginine Rich Region 11 2     DAPPER32
Antagonist Of Beta-Catenin Dapper Homolog 32 3     Dapper Homolog 32
Arginine-Rich Region 1 Protein2 3     Dapper, Antagonist Of Beta-Catenin, Homolog 32

External Ids:    HGNC: 307451   Entrez Gene: 1479062   Ensembl: ENSG000001973807   OMIM: 6111125   UniProtKB: Q96B183   

Export aliases for DACT3 gene to outside databases

Previous GC identifers: GC19M051844 GC19M043576


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DACT3 Gene:
DACT3 (dishevelled-binding antagonist of beta-catenin 3) is a protein-coding gene. Diseases associated with DACT3 include placenta praevia, and yellow fever. GO annotations related to this gene include protein kinase A binding and identical protein binding.

UniProtKB/Swiss-Prot: DACT3_HUMAN, Q96B18
Function: May be involved in regulation of intracellular signaling pathways during development. Specifically
thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH
(Dishevelled) family proteins




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DACT3 gene promoter:
         ER-alpha   TBP   AML1a   Pax-5   p53   Lmo2   CP2   TFIID   SEF-1 (1)   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDACT3 promoter sequence
   Search Chromatin IP Primers for DACT3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DACT3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

DACT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DACT3 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M047150:  view genomic region     (about GC identifiers)

Start:
47,150,869 bp from pter      End:
47,164,395 bp from pter
Size:
13,527 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DACT3_HUMAN, Q96B18 (See protein sequence)
Recommended Name: Dapper homolog 3  
Size: 629 amino acids; 64949 Da
Subunit: Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit,
PKC-type kinase, DVL1, DVL3, VANGL1, VANGL2 and CTNND1 (By similarity). Interacts with DVL2
Sequence caution: Sequence=AAH16161.1; Type=Frameshift; Positions=119;

Explore the universe of human proteins at neXtProt for DACT3: NX_Q96B18

Explore proteomics data for DACT3 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DACT3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_659493.2  
    ENSEMBL proteins: 
     ENSP00000300875   ENSP00000375783   ENSP00000387300  

    DACT3 Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for DACT3
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DACT3
    GenScript Custom Purified and Recombinant Proteins Services for DACT3
    Novus Biologicals DACT3 Protein
    Novus Biologicals DACT3 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DACT3

    DACT3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for DACT3 (DACT3/Dapper 3)
    OriGene Antibodies for DACT3
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    Novus Biologicals DACT3 Antibodies
    Search for Antibodies for DACT3 at Abcam
    Cloud-Clone Corp. Antibodies for DACT3
    ThermoFisher Antibodies for DACT3
    LSBio Antibodies in human, mouse, rat for DACT3

    DACT3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for DACT3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DACT3
    Cloud-Clone Corp. CLIAs for DACT3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR024844 Dact3
     IPR024843 Dapper

    Graphical View of Domain Structure for InterPro Entry Q96B18

    ProtoNet protein and cluster: Q96B18

    UniProtKB/Swiss-Prot: DACT3_HUMAN, Q96B18
    Domain: The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family
    proteins (By similarity)
    Similarity: Belongs to the dapper family


    DACT3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DACT3_HUMAN, Q96B18
    Function: May be involved in regulation of intracellular signaling pathways during development. Specifically
    thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH
    (Dishevelled) family proteins

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding ISS--
    GO:0005515protein binding ----
    GO:0042802identical protein binding IEA--
    GO:0051018protein kinase A binding ISS--
    GO:0070097delta-catenin binding ISS--
         
    DACT3 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dact3):
     growth/size/body  homeostasis/metabolism  renal/urinary system 

    DACT3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Dact3tm1.1Yegc for DACT3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DACT3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DACT3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DACT3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DACT3

    miRNA
    Products:
        
    miRTarBase miRNAs that target DACT3:
    hsa-mir-31-5p (MIRT005875)

    Block miRNA regulation of human, mouse, rat DACT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DACT3 (see all 29):
    hsa-miR-3934 hsa-miR-520d-5p hsa-miR-181c* hsa-miR-1285 hsa-miR-1205 hsa-miR-1257 hsa-miR-373* hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidDACT3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DACT3
    Predesigned siRNA for gene silencing in human, mouse, rat DACT3

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DACT3

    Clone
    Products:
         
    OriGene clones in human, mouse for DACT3 (see all 9)
    OriGene ORF clones in mouse, rat for DACT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DACT3 (NM_145056)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DACT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DACT3

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DACT3
    Browse ESI BIO Cell Lines and PureStem Progenitors for DACT3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACT3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DACT3
    Interactions:

        Search GeneGlobe Interaction Network for DACT3

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for DACT3 (Q96B183 ENSP000003757834) via UniProtKB, MINT, STRING, and/or I2D (see all 6)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    SH3GLB2Q9NR463I2D: score=1 
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    DVL1ENSP000003681694STRING: ENSP00000368169
    VANGL1ENSP000003108004STRING: ENSP00000310800
    VANGL2ENSP000003570404STRING: ENSP00000357040
    About this table

    Gene Ontology (GO): 4 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016055Wnt signaling pathway IEA--
    GO:0030178negative regulation of Wnt signaling pathway IDA18538736
    GO:0030308negative regulation of cell growth IDA18538736
    GO:0035414negative regulation of catenin import into nucleus IDA18538736

    DACT3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DACT3



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for DACT3 gene: 
    NM_145056.2  

    Unigene Cluster for DACT3:

    Dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
    Hs.515490  [show with all ESTs]
    Unigene Representative Sequence: NM_145056
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000300875 ENST00000391916(uc010ekq.3) ENST00000410105(uc002pfb.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DACT3 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DACT3 (see all 29):
    hsa-miR-3934 hsa-miR-520d-5p hsa-miR-181c* hsa-miR-1285 hsa-miR-1205 hsa-miR-1257 hsa-miR-373* hsa-miR-583
    SwitchGear 3'UTR luciferase reporter plasmidDACT3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DACT3
    Predesigned siRNA for gene silencing in human, mouse, rat DACT3
    Clone
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    OriGene clones in human, mouse for DACT3 (see all 9)
    OriGene ORF clones in mouse, rat for DACT3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DACT3 (NM_145056)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DACT3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DACT3
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for DACT3
    OriGene qSTAR qPCR primer pairs in human, mouse for DACT3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DACT3
      QuantiTect SYBR Green Assays in human, mouse, rat DACT3
      QuantiFast Probe-based Assays in human, mouse, rat DACT3

    Additional mRNA sequence: BC016161.1 

    4 DOTS entries:

    DT.97801727  DT.109829  DT.100020005  DT.91989023 

    Selected AceView cDNA sequences (see all 54):

    BM726884 AI761701 CD672022 AI039431 BF115250 AW027376 AI079827 AI333428 
    CD672028 AI141140 AI871500 CB051231 AI076469 AA339601 AW772108 AA335808 
    AW027732 AI553837 AI951237 BX097198 BG715516 BC034052 AI628092 BC016161 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DACT3 expression in normal human tissues (normalized intensities)      DACT3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCCCACTC
    DACT3 Expression
    About this image


    DACT3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Coronary Vessels
     
     Neural Crest (Gastrulation Derivatives)
             PureStem 4D20.8, NCr-fac Progenitor
     
     Smooth Muscle (Muscoskeletal System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Kidney (Urinary System)
             Juxtaglomerular Cells Afferent Arteriole
     
     Dermis (Integumentary System)
    DACT3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DACT3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.515490
        Custom PCR Arrays for DACT3
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat DACT3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DACT3 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dact31 , 5 dapper homolog 3, antagonist of beta-catenin (xenopus)1, 5 83.09(n)1
    88.43(a)1
      7 (9.15 cM)5
    6293781  NM_001081655.11  NP_001075124.11 
     168753175 
    lizard
    (Anolis carolinensis)
    Reptilia DACT36
    dishevelled-binding antagonist of beta-catenin 3
    38(a)
    1 ↔ 1
    AAWZ02039310(21-4989)
    zebrafish
    (Danio rerio)
    Actinopterygii DACT3 (1 of 2)6
    DACT3 (2 of 2)6
    dishevelled-binding antagonist of beta-catenin 3
    33(a)
    25(a)
    many → 1
    many → 1
    10(407728-422464) ENSDARG00000087910
    18(45219884-45238864) ENSDARG00000088409


    ENSEMBL Gene Tree for DACT3 (if available)
    TreeFam Gene Tree for DACT3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DACT3 (see all 257)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1115454301,2
    C,F--47150403(+) ATCCAC/TGCTGG 1 -- ds50011Minor allele frequency- T:0.50CSA 2
    rs1829288131,2
    --47150409(+) GCTGGC/TGTGCA 1 -- ds50010--------
    rs104219871,2
    C--47150594(+) GCTCAA/GGATAT 1 -- ds50015Minor allele frequency- G:0.08NA WA EA 244
    rs1451109531,2
    --47150767(+) CCTGG-/AAAACT 1 -- ds50010--------
    rs1391164651,2
    C--47150770(+) GGAAA-/CCTGCC 1 -- ds50010--------
    rs1871331811,2
    --47150807(+) AATAAA/GTGTTA 1 -- ds50010--------
    rs1429360791,2
    --47150827(+) AAAAAG/TAGCAT 1 -- ds50010--------
    rs1389264101,2
    C--47150908(+) GAGAA-/ACACACA 1 -- ut310--------
    rs455062031,2
    C--47150935(+) TTTGCA/GCTGGG 1 -- ut310--------
    rs1906253541,2
    --47151103(+) CCTCCA/GTAATT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for DACT3 (47150869 - 47164395 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for DACT3:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3961n71CNV Loss21882294
    nsv833849CNV Loss17160897
    nsv828570CNV Gain20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DACT3
    DNA2.0 Custom Variant and Variant Library Synthesis for DACT3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 611112    OMIM disorders: --

    3 diseases for DACT3:    About MalaCards
    placenta praevia    yellow fever    colorectal cancer

    1 disease from the University of Copenhagen DISEASES database for DACT3:
    Placenta praevia

    DACT3 for disorders           About GeneDecksing


    Export disorders for DACT3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DACT3 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with DACT3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. (PubMed id 16881060)1, 2, 3 Fisher D.A.... Cheyette B.N.R. (Dev. Dyn. 2006)
    2. DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. (PubMed id 18538736)1, 2 Jiang X.... Yu Q. (Cancer Cell 2008)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Pathway Analysis of ChIP-Seq-Based NRF1 Target Genes Suggests a Logical Hypothesis of their Involvement in the Pathogenesis of Neurodegenerative Diseases. (PubMed id 24250222)1 Satoh J....Yamamoto Y. (Gene Regul Syst Bio 2013)
    5. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. (PubMed id 21718540)1 Kivimae S.... Cheyette B.N. (BMC Biochem. 2011)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 147906 HGNC: 30745 AceView: MGC15476 Ensembl:ENSG00000197380 euGenes: HUgn147906
    ECgene: DACT3 H-InvDB: DACT3

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DACT3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DACT3 gene:
    Search GeneIP for patents involving DACT3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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