Aliases for DACT3 Gene
Aliases for DACT3 Gene
External Ids for DACT3 Gene
- HGNC: 30745
- Entrez Gene: 147906
- Ensembl: ENSG00000197380
- OMIM: 611112
- UniProtKB: Q96B18
Previous HGNC Symbols for DACT3 Gene
- RRR1
Previous GeneCards Identifiers for DACT3 Gene
- GC19M051844
- GC19M047150
- GC19M043576
Summaries for DACT3 Gene
GeneCards Summary for DACT3 Gene
DACT3 (Dishevelled Binding Antagonist Of Beta Catenin 3) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and protein kinase A binding.
UniProtKB/Swiss-Prot for DACT3 Gene
-
May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.
No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DACT3 Gene
Genomics for DACT3 Gene
Regulatory Elements for DACT3 Gene
Regulatory Element Products
Genomic Location for DACT3 Gene
- Chromosome:
- 19
- Start:
- 46,647,564 bp from pter
- End:
- 46,661,138 bp from pter
- Size:
- 13,575 bases
- Orientation:
- Minus strand
Genomic View for DACT3 Gene
- Cytogenetic band:
-
- 19q13.32 by Ensembl
- 19q13.32 by Entrez Gene
- 19q13.32 by HGNC
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for DACT3 Gene
Proteins for DACT3 Gene
-
Protein details for DACT3 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q96B18-DACT3_HUMAN
- Recommended name:
- Dapper homolog 3
- Protein Accession:
- Q96B18
Protein attributes for DACT3 Gene
- Size:
- 629 amino acids
- Molecular mass:
- 64949 Da
- Quaternary structure:
-
- Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, DVL1, DVL3, VANGL1, VANGL2 and CTNND1 (By similarity). Interacts with DVL2.
- SequenceCaution:
-
- Sequence=AAH16161.1; Type=Frameshift; Positions=119; Evidence={ECO:0000305};
Protein Expression for DACT3 Gene
Post-translational modifications for DACT3 Gene
Other Protein References for DACT3 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- R&D Systems Antibodies for DACT3 (DACT3/Dapper 3)
-
Custom Antibody ServicesOriGene Antibodies for DACT3
- Novus Biologicals Antibodies for DACT3
- Invitrogen Antibodies for DACT3
- GeneTex DACT3 antibody for DACT3
-
Custom Antibody ServicesProSci Antibodies for DACT3
-
Santa Cruz Biotechnology (SCBT) Antibodies for DACT3
Protein Products
-
OriGene Purified Proteins for DACT3
- Search Origene for MassSpec and Protein Over-expression Lysates for DACT3
- Origene Custom Protein Services for DACT3
- Search GeneTex for Proteins for DACT3
Assay Products
No data available for DME Specific Peptides for DACT3 Gene
Domains & Families for DACT3 Gene
Suggested Antigen Peptide Sequences for DACT3 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q96B18UniProtKB/Swiss-Prot:
DACT3_HUMAN :- The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
- Belongs to the dapper family.
- Domain:
-
- The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
- Family:
-
- Belongs to the dapper family.
No data available for Gene Families for DACT3 Gene
Function for DACT3 Gene
Molecular function for DACT3 Gene
- UniProtKB/Swiss-Prot Function:
- May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005080 | protein kinase C binding | ISS | -- |
| GO:0008013 | beta-catenin binding | IBA | -- |
| GO:0042802 | identical protein binding | IEA | -- |
| GO:0051018 | protein kinase A binding | ISS,IEA | -- |
| GO:0070097 | delta-catenin binding | ISS,IEA | -- |
Phenotypes for DACT3 Gene
- MGI mutant phenotypes for DACT3:
- inferred from 2 alleles
- GenomeRNAi human phenotypes for DACT3:
-
- Increased vaccinia virus (VACV) infection
- Decreased viability
- Mildly decreased CFP-tsO45G cell surface transport
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection
- Decreased IL-8 secretion
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after viral supernatant infection
- Decreased JFH-1 genotype 2a Hepatitis C virus (HCV) infection after direct virus infection
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for DACT3
-
-
ViGene Biosciences lentiviral particle packaged cDNA for DACT3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DACT3 gene
- Search ViGene Biosciences for DACT3
CRISPR Products
-
OriGene CRISPR knockouts for DACT3
-
Santa Cruz Biotechnology (SCBT) CRISPR for DACT3
- GenScript: Design CRISPR guide RNA sequences for DACT3
miRNA for DACT3 Gene
- miRTarBase miRNAs that target DACT3
miRNA Products
- Search ViGene Biosciences for DACT3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for DACT3
- Browse OriGene Inhibitory RNA Products For DACT3
-
ViGene Biosciences ready-to-package AAV shRNAs for DACT3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DACT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DACT3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for DACT3
-
ViGene Biosciences adenoviral particle packaged cDNA for DACT3 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for DACT3 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for DACT3 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DACT3 Gene
Localization for DACT3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005737 | cytoplasm | IEA,IBA | -- |
No data available for Subcellular locations from UniProtKB/Swiss-Prot for DACT3 Gene
Pathways & Interactions for DACT3 Gene
Interacting Proteins for DACT3 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0010719 | negative regulation of epithelial to mesenchymal transition | IEA | -- |
| GO:0016055 | Wnt signaling pathway | IEA | -- |
| GO:0030178 | negative regulation of Wnt signaling pathway | IDA | 18538736 |
| GO:0030308 | negative regulation of cell growth | IDA | 18538736 |
| GO:0035414 | negative regulation of catenin import into nucleus | IDA | 18538736 |
No data available for Pathways by source and SIGNOR curated interactions for DACT3 Gene
Transcripts for DACT3 Gene
mRNA/cDNA for DACT3 Gene
- (5) REFSEQ mRNAs :
- (1) Additional mRNA sequences :
- (54) Selected AceView cDNA sequences:
- (3) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for DACT3 Gene
CRISPR Products
-
OriGene CRISPR knockouts for DACT3
-
Santa Cruz Biotechnology (SCBT) CRISPR for DACT3
- GenScript: Design CRISPR guide RNA sequences for DACT3
miRNA Products
- Search ViGene Biosciences for DACT3
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for DACT3
- Browse OriGene Inhibitory RNA Products For DACT3
-
ViGene Biosciences ready-to-package AAV shRNAs for DACT3 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for DACT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DACT3
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for DACT3 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Heart (Cardiovascular System)
-
Kidney (Urinary System)
- Juxtaglomerular Cells Afferent Arteriole
-
Smooth Muscle (Muscoskeletal System)
- Juxtaglomerular Cells Afferent Arteriole
- Neural Crest (Gastrulation Derivatives)
-
Dermis (Integumentary System)
mRNA differential expression in normal tissues according to GTEx for DACT3 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DACT3 Gene
NURSA nuclear receptor signaling pathways regulating expression of DACT3 Gene:
DACT3SOURCE GeneReport for Unigene cluster for DACT3 Gene:
Hs.515490Evidence on tissue expression from TISSUES for DACT3 Gene
- Skin(4)
Primer Products
-
OriGene qPCR primer pairs and template standards for DACT3
-
OriGene qPCR primer pairs for DACT3
No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DACT3 Gene
Orthologs for DACT3 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | DACT3 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | DACT3 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | DACT3 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Dact3 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Dact3 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | DACT3 35 |
|
OneToOne | |
| lizard (Anolis carolinensis) |
Reptilia | DACT3 35 |
|
OneToOne | |
| zebrafish (Danio rerio) |
Actinopterygii | DACT3 (1 of 2) 35 |
|
OneToMany | |
| DACT3 (2 of 2) 35 |
|
OneToMany |
- Species where no ortholog for DACT3 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- oppossum (Monodelphis domestica)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for DACT3 Gene
No data available for Paralogs for DACT3 Gene
Variants for DACT3 Gene
| SNP ID | Clin | Chr 19 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000002893 | -- | 46,655,030(+) | TAACT(-/A/AA)AAAAA | intron-variant, upstream-variant-2KB | |
| rs1000382144 | -- | 46,652,051(+) | ACCAC(A/G)CCTAG | intron-variant | |
| rs1000489805 | -- | 46,658,126(+) | AGTAG(C/T)TCACA | intron-variant | |
| rs1000541420 | -- | 46,647,257(+) | CTACC(A/C)CACCC | downstream-variant-500B | |
| rs1000602364 | -- | 46,653,948(+) | CCTGC(C/T)GCAGA | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| dgv1789n106 | CNV | deletion | 24896259 |
| nsv1072888 | CNV | deletion | 25765185 |
| nsv828570 | CNV | gain | 20364138 |
| nsv833849 | CNV | loss | 17160897 |
Relevant External Links for DACT3 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- DACT3
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DACT3 Gene
Disorders for DACT3 Gene
Relevant External Links for DACT3
- Atlas of Genetics and Cytogenetics in Oncology and Haematology:
- DACT3
No disorders were found for DACT3 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DACT3 Gene
Publications for DACT3 Gene
- Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. (PMID: 16881060) Fisher D.A. … Cheyette B.N.R. (Dev. Dyn. 2006) 2 3 4 64
- DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. (PMID: 18538736) Jiang X. … Yu Q. (Cancer Cell 2008) 3 4 64
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
- Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
- All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. (PMID: 21718540) Kivimae S. … Cheyette B.N. (BMC Biochem. 2011) 3 64
Products for DACT3 Gene
- R&D Systems Antibodies for DACT3 (DACT3/Dapper 3)
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
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- Custom Antibody ServicesOriGene Antibodies for DACT3
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for DACT3
- Search Origene for MassSpec and Protein Over-expression Lysates for DACT3
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for DACT3
- Browse OriGene Inhibitory RNA Products For DACT3
- OriGene qPCR primer pairs and template standards for DACT3
- OriGene qPCR primer pairs for DACT3
- OriGene CRISPR knockouts for DACT3
- OriGene ORF clones in human for DACT3
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
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- GenScript: Next-day shipping cDNA ORF clone for DACT3 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for DACT3
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- GenScript Custom overexpressing Cell Line Services for DACT3
- GenScript: Design CRISPR guide RNA sequences for DACT3
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for DACT3
- Browse Sino Biological cDNA Clones
- Browse Sino Biological Cell Lysates
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- Sino Biological Antibodies
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- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
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- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for DACT3
- Novus Biologicals proteins and lysates for DACT3
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- ViGene Biosciences adenoviral particle packaged cDNA for DACT3 gene
- ViGene Biosciences lentiviral particle packaged cDNA for DACT3 gene
- ViGene Biosciences ready-to-package AAV shRNAs for DACT3 gene
- Search ViGene Biosciences for DACT3
- Santa Cruz Biotechnology (SCBT) Antibodies for DACT3
- Search Santa Cruz Biotechnology (SCBT) for DACT3 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for DACT3
- Custom Antibody ServicesProSci Antibodies for DACT3
- Search for DACT3 Proteins at ProSci
- Horizon Cell Lines for DACT3
- Cyagen custom Knockout/knockin (KOKI) mouse models for DACT3
- VectorBuilder custom plasmid, inducible vectors for DACT3
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for DACT3
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for DACT3 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
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- (122) diseasecard
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- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer




