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DACT3 Gene

protein-coding   GIFtS: 41

GC19M051844
dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
(Previous name: arginine rich region 1 )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: RRR1)
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Aliases &
Descriptions
for DACT3

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
About This Section
Aliases
MGC15476 1, 2
RRR1 2, 3
Descriptions
Antagonist of beta-catenin Dapper homolog 3 3
Arginine-rich region 1 protein 3
arginine rich region 1 1, 2
dapper, antagonist of beta-catenin, homolog 3 (Xenopus
laevis) 2
thymus expressed gene 3-like 2
External Ids
HGNC: 307451
Entrez Gene: 1479062
UniProtKB: Q96B183
Ensembl: ENSG000001973807
Search outside databases for aliases for DACT3 gene

Summaries
for DACT3

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

   --

Genomic Location
for DACT3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

 Genomic View:
UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.32   HGNC cytogenetic band: 19q13.32

DACT3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M051844:     (about GC identifiers)

Start:
 51,842,709 bp from pter
End:
 51,856,235 bp from pter
Size:
 13,527 bases
Orientation:
 minus strand
RefSeq DNA sequence:
NC_000019.8  NT_011109.15  

Proteins
for DACT3

(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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 UniProtKB/Swiss-Prot: DACT3_HUMAN, Q96B18 (See protein sequence)
Recommended Name: Dapper homolog 3  
Size: 629 amino acids; 64949 Da
Sequence caution: Sequence=AAH16161.1; Type=Frameshift; Positions=119;

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


    • REFSEQ proteins: NP_659493.2  

    ENSEMBL proteins: 
    ENSP00000375783 ENSP00000300875 ENSP00000387300 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Browse Human Recombinant Proteins at Sigma-Aldrich  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (Dact3)
    Browse Abnova for Human Recombinant Proteins
                  OriGene Purified Recombinant Human Protein: DACT3 


    Antibodies for DACT3: 
    Browse Antibodies Central at Invitrogen
    Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Sigma-Aldrich Antibodies for DACT3
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (Dact3), each with their AbpromiseSM
    Browse Abnova for Monoclonal and Polyclonal Antibodies
    Search Novus for antibodies for DACT3

    Assays for DACT3: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    Protein Domains/
    Families
    for DACT3

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q96B18

    UniProtKB/Swiss-Prot: DACT3_HUMAN, Q96B18
    Domain: The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH
    (Dishevelled) family proteins (By similarity)
    Similarity: Belongs to the dapper family

    Gene Function
    for DACT3

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (DACT3)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145056

                  Applied Biosystems Silencer® siRNAs for DACT3

                  Sigma-Aldrich siRNA for DACT3  
                         Sigma-Aldrich shRNA for DACT3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Browse Clone Ranger at Invitrogen for clones
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_145056
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_145056
                                     untagged cDNA clone in CMV expression vector: NM_145056 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_145056

    Pathways & Interactions
    for DACT3

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    1 Interacting protein for DACT3 (ENSP000003008753) via UniProtKB, MINT, and/or STRING
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DACT2ENSP000003557603STRING (score=.901)
    About this table

    Drugs & Compounds
    for DACT3

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for DACT3

    Transcripts
    for DACT3

    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene,
    Expression Assays from Applied Biosystems)
    About This Section
    Inhib.
    RNA:    		Invitrogen RNAi Products for gene knock-down (DACT3)
    Browse for Gene Knock-down Tools from Millipore
    Browse Abnova for Chimera RNAi Products
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_145056

                  Sigma-Aldrich siRNA for DACT3  
                         Sigma-Aldrich shRNA for DACT3  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_145056  

    REFSEQ mRNAs for DACT3 gene: 

    NM_145056.2   

    Applied Biosystems TaqMan ® Gene Expression Assays: 

    NM_145056  

                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_145056
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_145056
                                     untagged cDNA clone in CMV expression vector: NM_145056 

    Additional cDNA sequence: BC016161.1 

    4 DOTS entries:

    DT.97801727  DT.109829  DT.100020005  DT.91989023 

    24/54 AceView cDNA sequences (see all 54 ):

    CD672028 AI141140 AI079827 BM726884 AI076469 AW027376 AI039431 AI871500 
    AI761701 CB051231 CD672022 AI333428 BF115250 AI160661 AA663607 BI603646 
    AI038326 AI628092 AA339601 NM_145056 BX097198 AW089289 AA609133 AA328522 

    highest scoring ESTs for DACT3:

    AI076469 AI079827 AI141140 AI333428 AI458010 AI553837 AI691082 AI761701 AI762453 AI809234 

    Unigene Cluster for DACT3:

    Dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis)
    Hs.515490  [show with all ESTs]
    Unigene Representative Sequence: NM_145056


    GeneLoc Exon Structure

    3 Ensembl transcripts including schematic representations:
    ENST00000391916  ENST00000300875  ENST00000410105  

    Expression
    for DACT3

    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    DACT3 expression in normal and diseased human tissues

     Applied Biosystems TaqMan ® Gene Expression Assays for DACT3

    1 / 2 / 3

    6 probe-sets matching DACT3 gene


    		Affymetrix
    probe-set    		 Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank
    58917_at2, 3 U95-B 1 1.00 1.00 1.00 1.00 AI809234 0.80 1.00 0.91 1

    		76791_at*2, 3 U95-E 1 -- -- -0.20 0.24 AI468629 0.60 1.00 0.82 1

    		228228_at2, 3 U133-B 1 1.00 1.00 -- -- AI809234 0.80 1.00 0.91 1

    		229745_x_at*2, 3 U133-B NULL 0.00 0.00 -- -- AI468629 0.60 1.00 0.82 1

    		228228_at2 U133Plus2 1 1.00 1.00 -- -- -- -- -- -- --

    		229745_x_at*2 U133Plus2 NULL 0.00 0.00 -- -- -- -- -- -- --
    GeneDecks  DACT3 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: ACCCCCACTC

    SOURCE GeneReport for Unigene cluster: Hs.515490

    Orthologs
    for DACT3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section
    Orthologs for DACT3 gene from 3 species
    Organism Gene Locus Description Human
    Similarity    		 NCBI accessions
    rat
    (Rattus norvegicus)    		 RGD15638921   -- similar to MGC15476 protein 80.8(n)
    84.82(a)    		 499088  XM_574375.2  XP_574375.2 
    mouse
    (Mus musculus)    		 Dact31, 5 75
    		 dapper homolog 3, antagonist of beta-catenin (xenopus)1, 5 80.45(n)1
    85.86(a)1    		 6293781  NM_001081655.11  NP_001075124.11 
     AB0739715  DQ8323195 
    zebrafish
    (Danio rerio)    		 LOC1000008901   -- similar to Dapper homolog 3 (Antagonist of beta-catenin more 58.23(n)
    65.06(a)    		 100000890  XM_001340960.1  XP_001340996.1 
    About this table        Species with no ortholog for DACT3

    ENSEMBL Gene Tree for DACT3

    Paralogs
    for DACT3

    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for DACT3 gene
    DACT12  DACT22  

    SNPs/Variants
    for DACT3

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/65 NCBI SNPs in DACT3 are shown (see all 65 )
    (Click for Applied Biosystems TaqMan ® Genotyping Assay)  (see all 17)
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg    		TypeMoreRecsAllele
    freq    		PopTotal
    sample    		More
    ------------
    rs22706831,2
    		A,C,F,H51843218(+) CGGTGG/AAGGGG 1 -- ut315Minor allele frequency- A:0.24EA EU WA 1918
    rs124629461,2
    		C,F,H51850795(+) aacgcA/Ggagat 1 -- ng313Minor allele frequency- G:0.37EU EA 298
    --
    rs72539551,2
    		A,C51850431(+) AGGCCA/GGGCTC 1 -- ng310--------
    rs10587081,2
    		C51842977(-) GGAAAG/AAAGGA 1 -- ut311Minor allele frequency- A:0.00MN 184
    --
    rs81060511,2
    		A,C51846424(+) ctgccC/Tgtctc 1 -- int10--------
    --
    rs81095351,2
    		A,C51847087(+) cagggC/Ttcaag 1 -- int10--------
    --
    rs104101371,2
    		C51849411(+) aacctC/Tgtctc 1 -- int10--------
    --
    rs43271611,2
    		A51846045(+) TCCCTC/TCCCAA 1 -- int1 tfbs3 trp30--------
    rs126099091,2
    		H51848389(+) TCATGC/GTGCAG 1 -- int14Minor allele frequency- G:0.00EU EA WA 418
    rs104096621,2
    		H51849219(+) CATCCT/CCCTTC 1 -- int1 trp31Minor allele frequency- C:0.00EU 120
    About this table

    HapMap Linkage Disequilibrium images for DACT3 (up to first 250kb)

    Disorders & Mutations
    for DACT3

    (in which this Gene is Involved, According to OMIM, UniProtKB, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    		 OMIM: 611112

    Medical News
    for DACT3

    (Possibly Related Articles in Doctor's Guide)
    About This Section

    		   --

    Publications
    for DACT3

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    		4 PubMed articles for DACT3 gene:

    Search for DACT3

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DACT3

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section
    Entrez Gene: 147906 HGNC: 30745 AceView: MGC15476 Ensembl:ENSG00000197380 euGenes: HUgn147906
    ECgene: DACT3 H-InvDB: DACT3

    Other Databases showing DACT3

    (According to HUGE)
    About This Section

    		   --

    Specialized Databases showing DACT3

    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    		   --

    Licensable Technologies
    for DACT3

    (Available from WIS Yeda, Salk, Tufts)
    About This Section

    		  --

    Services
    for DACT3

    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for DACT3:
     TaqMan ® Gene Expression Assays
     TaqMan ® Genotyping Assays
    		  Free SNP selection tool



      Invitrogen iPath Pathways  Invitrogen BLOCK-iT™ RNAi
      Invitrogen Antibodies  Invitrogen Assays
      Invitrogen Clones  Invitrogen Q-PCR Products
      Invitrogen Human Recombinant Kinases  Invitrogen Custom Antibody and Peptide Service
      Invitrogen Proteins / Assays / Screening Services  Search Invitrogen catalog for DACT3-related products

     Millipore Custom Antibody & Bulk Services
     Millipore Preclinical / Clinical Development Services
     Millipore Immunoassay Services
     Millipore Target Screening & Profiling Services


     Predesigned and custom siRNAs for DACT3 Antibodies for DACT3
     Explore super-pooled esiRNAs Browse proteins at Sigma-Aldrich
     Lentivirus-delivered shRNAs for DACT3 Browse small molecules at Sigma-Aldrich
     "Your Favorite Gene" Pathwaysfeedback


      
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     Recombinant & Natural Proteins  

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     Recombinant Proteins
    (Dact3)
     Antibodies (Dact3)
     Tagged/untagged cDNA clones
     Validated SYBR primer pairs
     Purified proteins from HEK293T cells
     Western blot validated antibodies
     shRNA in GFP-retroviral vector
     Search Tocris compounds for DACT3




     Search www.enzolifesicences.com for proteins, assays, substrates, inhibitors & antibodies
     Search Novus for antibodies for DACT3

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