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Aliases for DACT3 Gene

Aliases for DACT3 Gene

  • Dishevelled-Binding Antagonist Of Beta-Catenin 3 2 3
  • Antagonist Of Beta-Catenin Dapper Homolog 3 3 4
  • Arginine-Rich Region 1 Protein 3 4
  • RRR1 3 4
  • Dapper, Antagonist Of Beta-Catenin, Homolog 3 (Xenopus Laevis) 2
  • Dapper, Antagonist Of Beta-Catenin, Homolog 3 3
  • Dapper Antagonist Of Catenin 3 4
  • Arginine Rich Region 1 2
  • Dapper Homolog 3 3
  • DAPPER3 3

External Ids for DACT3 Gene

Previous HGNC Symbols for DACT3 Gene

  • RRR1

Previous GeneCards Identifiers for DACT3 Gene

  • GC19M051844
  • GC19M047150
  • GC19M043576

Summaries for DACT3 Gene

GeneCards Summary for DACT3 Gene

DACT3 (Dishevelled-Binding Antagonist Of Beta-Catenin 3) is a Protein Coding gene. Diseases associated with DACT3 include placenta praevia. GO annotations related to this gene include identical protein binding and protein kinase A binding.

UniProtKB/Swiss-Prot for DACT3 Gene

  • May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DACT3 Gene

Genomics for DACT3 Gene

Regulatory Elements for DACT3 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DACT3 Gene

Start:
46,647,612 bp from pter
End:
46,661,138 bp from pter
Size:
13,527 bases
Orientation:
Minus strand

Genomic View for DACT3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DACT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DACT3 Gene

Proteins for DACT3 Gene

  • Protein details for DACT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B18-DACT3_HUMAN
    Recommended name:
    Dapper homolog 3
    Protein Accession:
    Q96B18
    Secondary Accessions:

    Protein attributes for DACT3 Gene

    Size:
    629 amino acids
    Molecular mass:
    64949 Da
    Quaternary structure:
    • Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, DVL1, DVL3, VANGL1, VANGL2 and CTNND1 (By similarity). Interacts with DVL2.
    SequenceCaution:
    • Sequence=AAH16161.1; Type=Frameshift; Positions=119; Evidence={ECO:0000305};

neXtProt entry for DACT3 Gene

Proteomics data for DACT3 Gene at MOPED

Post-translational modifications for DACT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DACT3 Gene

No data available for DME Specific Peptides for DACT3 Gene

Domains for DACT3 Gene

Protein Domains for DACT3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DACT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96B18

UniProtKB/Swiss-Prot:

DACT3_HUMAN :
  • Q96B18
Domain:
  • The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
Family:
  • Belongs to the dapper family.
genes like me logo Genes that share domains with DACT3: view

No data available for Gene Families for DACT3 Gene

Function for DACT3 Gene

Molecular function for DACT3 Gene

UniProtKB/Swiss-Prot Function: May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.

Gene Ontology (GO) - Molecular Function for DACT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding ISS --
GO:0005515 protein binding --
GO:0042802 identical protein binding IEA --
GO:0051018 protein kinase A binding ISS --
GO:0070097 delta-catenin binding ISS --
genes like me logo Genes that share ontologies with DACT3: view
genes like me logo Genes that share phenotypes with DACT3: view

Animal Models for DACT3 Gene

MGI Knock Outs for DACT3:

Animal Model Products

CRISPR Products

miRNA for DACT3 Gene

miRTarBase miRNAs that target DACT3

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DACT3

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DACT3 Gene

Localization for DACT3 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DACT3 Gene COMPARTMENTS Subcellular localization image for DACT3 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DACT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DACT3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DACT3 Gene

Pathways for DACT3 Gene

SuperPathways for DACT3 Gene

No Data Available

Interacting Proteins for DACT3 Gene

Gene Ontology (GO) - Biological Process for DACT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010719 negative regulation of epithelial to mesenchymal transition IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IDA 18538736
GO:0030308 negative regulation of cell growth IDA 18538736
GO:0035414 negative regulation of catenin import into nucleus IDA 18538736
genes like me logo Genes that share ontologies with DACT3: view

No data available for Pathways by source for DACT3 Gene

Transcripts for DACT3 Gene

Unigene Clusters for DACT3 Gene

Dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DACT3

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DACT3 Gene

No ASD Table

Relevant External Links for DACT3 Gene

GeneLoc Exon Structure for
DACT3
ECgene alternative splicing isoforms for
DACT3

Expression for DACT3 Gene

mRNA expression in normal human tissues for DACT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DACT3 Gene

This gene is overexpressed in Artery - Tibial (4.4) and Artery - Aorta (4.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DACT3 Gene

SOURCE GeneReport for Unigene cluster for DACT3 Gene Hs.515490

genes like me logo Genes that share expressions with DACT3: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DACT3 Gene

Orthologs for DACT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DACT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DACT3 35
  • 99.1 (n)
  • 98.89 (a)
DACT3 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DACT3 35
  • 88.65 (n)
  • 92.08 (a)
DACT3 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DACT3 35
  • 92.28 (n)
  • 92.38 (a)
DACT3 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dact3 35
  • 83.09 (n)
  • 88.43 (a)
Dact3 16
Dact3 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DACT3 36
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dact3 35
  • 82.81 (n)
  • 87.6 (a)
lizard
(Anolis carolinensis)
Reptilia DACT3 36
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii DACT3 (1 of 2) 36
  • 33 (a)
OneToMany
DACT3 (2 of 2) 36
  • 25 (a)
OneToMany
Species with no ortholog for DACT3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DACT3 Gene

ENSEMBL:
Gene Tree for DACT3 (if available)
TreeFam:
Gene Tree for DACT3 (if available)

Paralogs for DACT3 Gene

No data available for Paralogs for DACT3 Gene

Variants for DACT3 Gene

Sequence variations from dbSNP and Humsavar for DACT3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1058708 -- 46,647,880(-) GGAAA(A/G)AAGGA utr-variant-3-prime
rs1058712 -- 46,647,806(-) GGTTT(C/T)TATCT utr-variant-3-prime
rs1058715 -- 46,647,790(-) CCCCC(A/C)CTCCC utr-variant-3-prime
rs2270683 -- 46,648,121(+) CGGTG(A/G)AGGGG utr-variant-3-prime
rs4283327 -- 46,650,822(+) cagat(G/T)cccgg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DACT3 Gene

Variant ID Type Subtype PubMed ID
nsv833849 CNV Loss 17160897
dgv3961n71 CNV Loss 21882294
nsv828570 CNV Gain 20364138

Relevant External Links for DACT3 Gene

HapMap Linkage Disequilibrium report
DACT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DACT3 Gene

Disorders for DACT3 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DACT3 Gene including...

Search for DACT3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for DACT3 Gene

genes like me logo Genes that share disorders with DACT3: view

No data available for UniProtKB/Swiss-Prot for DACT3 Gene

Publications for DACT3 Gene

  1. Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. (PMID: 16881060) Fisher D.A. … Cheyette B.N.R. (Dev. Dyn. 2006) 2 3 4
  2. DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. (PMID: 18538736) Jiang X. … Yu Q. (Cancer Cell 2008) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. (PMID: 21718540) Kivimae S. … Cheyette B.N. (BMC Biochem. 2011) 3

Products for DACT3 Gene

Sources for DACT3 Gene

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