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Aliases for DACT3 Gene

Aliases for DACT3 Gene

  • Dishevelled Binding Antagonist Of Beta Catenin 3 2 3 5
  • Antagonist Of Beta-Catenin Dapper Homolog 3 3 4
  • Arginine-Rich Region 1 Protein 3 4
  • RRR1 3 4
  • Dapper, Antagonist Of Beta-Catenin, Homolog 3 (Xenopus Laevis) 2
  • Dapper, Antagonist Of Beta-Catenin, Homolog 3 3
  • Dapper Antagonist Of Catenin 3 4
  • Arginine Rich Region 1 2
  • Dapper Homolog 3 3
  • DAPPER3 3

External Ids for DACT3 Gene

Previous HGNC Symbols for DACT3 Gene

  • RRR1

Previous GeneCards Identifiers for DACT3 Gene

  • GC19M051844
  • GC19M047150
  • GC19M043576

Summaries for DACT3 Gene

GeneCards Summary for DACT3 Gene

DACT3 (Dishevelled Binding Antagonist Of Beta Catenin 3) is a Protein Coding gene. GO annotations related to this gene include identical protein binding and protein kinase A binding.

UniProtKB/Swiss-Prot for DACT3 Gene

  • May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DACT3 Gene

Genomics for DACT3 Gene

Regulatory Elements for DACT3 Gene

Enhancers for DACT3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G046859 2.1 FANTOM5 Ensembl ENCODE dbSUPER 3.4 -202.3 -202297 8.5 MLX CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF263 SP3 NFYC ZC3H4 ARHGAP35 SLC1A5 TMEM160 CCDC9 EHD2 SAE1 AP2S1 PNMA8A PNMA8B
GH19G046943 1.9 FANTOM5 Ensembl ENCODE dbSUPER 2.1 -284.8 -284792 5.8 HDGF PKNOX1 ARNT CREB3L1 ARID4B FEZF1 YY1 ZNF263 SP3 REST ENSG00000268810 ZC3H4 DACT3 MEIS3 ARHGAP35 NPAS1 PNMA8B PNMA8A ENSG00000279948 PIR40993
GH19G046295 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.2 +360.6 360598 9.4 PKNOX1 FOXA2 ZNF133 SIN3A ARID4B ZNF121 GLIS2 KLF7 SP3 SP5 PPP5C HIF3A ENSG00000269124 FOSB IGFL3 MYPOP IRF2BP1 CCDC8 DACT3 GC19M046308
GH19G046504 0.5 FANTOM5 3.2 +156.9 156879 0.3 MXI1 RFX1 ZSCAN4 EP300 PNMA8A PNMA8B DACT3 CALM3 GC19P046501 GC19M046508
GH19G046658 1.3 ENCODE dbSUPER 0.7 +0.5 474 4.2 HDGF PKNOX1 FOXA2 CREB3L1 ARNT WRNIP1 ARID4B SIN3A YY1 SLC30A9 ZC3H4 BICRA GNG8 ENSG00000268746 PRKD2 ENSG00000268810 INAFM1 STRN4 DACT3 DACT3-AS1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DACT3 on UCSC Golden Path with GeneCards custom track

Promoters for DACT3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000110406 -62 1201 HDGF PKNOX1 FOXA2 ATF1 CREB3L1 ARID4B SIN3A YY1 SLC30A9 ZNF121

Genomic Location for DACT3 Gene

Chromosome:
19
Start:
46,647,564 bp from pter
End:
46,661,138 bp from pter
Size:
13,575 bases
Orientation:
Minus strand

Genomic View for DACT3 Gene

Genes around DACT3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DACT3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DACT3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DACT3 Gene

Proteins for DACT3 Gene

  • Protein details for DACT3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B18-DACT3_HUMAN
    Recommended name:
    Dapper homolog 3
    Protein Accession:
    Q96B18

    Protein attributes for DACT3 Gene

    Size:
    629 amino acids
    Molecular mass:
    64949 Da
    Quaternary structure:
    • Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, DVL1, DVL3, VANGL1, VANGL2 and CTNND1 (By similarity). Interacts with DVL2.
    SequenceCaution:
    • Sequence=AAH16161.1; Type=Frameshift; Positions=119; Evidence={ECO:0000305};

neXtProt entry for DACT3 Gene

Post-translational modifications for DACT3 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DACT3 Gene

No data available for DME Specific Peptides for DACT3 Gene

Domains & Families for DACT3 Gene

Protein Domains for DACT3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DACT3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96B18

UniProtKB/Swiss-Prot:

DACT3_HUMAN :
  • The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
  • Belongs to the dapper family.
Domain:
  • The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
Family:
  • Belongs to the dapper family.
genes like me logo Genes that share domains with DACT3: view

No data available for Gene Families for DACT3 Gene

Function for DACT3 Gene

Molecular function for DACT3 Gene

UniProtKB/Swiss-Prot Function:
May be involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins.

Gene Ontology (GO) - Molecular Function for DACT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding ISS --
GO:0008013 beta-catenin binding IBA --
GO:0042802 identical protein binding IEA --
GO:0051018 protein kinase A binding ISS,IEA --
GO:0070097 delta-catenin binding ISS,IEA --
genes like me logo Genes that share ontologies with DACT3: view
genes like me logo Genes that share phenotypes with DACT3: view

Animal Models for DACT3 Gene

MGI Knock Outs for DACT3:

Animal Model Products

CRISPR Products

miRNA for DACT3 Gene

miRTarBase miRNAs that target DACT3

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DACT3 Gene

Localization for DACT3 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DACT3 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DACT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA,IBA --
genes like me logo Genes that share ontologies with DACT3: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DACT3 Gene

Pathways & Interactions for DACT3 Gene

SuperPathways for DACT3 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DACT3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0010719 negative regulation of epithelial to mesenchymal transition IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030178 negative regulation of Wnt signaling pathway IDA 18538736
GO:0030308 negative regulation of cell growth IDA 18538736
GO:0035414 negative regulation of catenin import into nucleus IDA 18538736
genes like me logo Genes that share ontologies with DACT3: view

No data available for Pathways by source and SIGNOR curated interactions for DACT3 Gene

Drugs & Compounds for DACT3 Gene

No Compound Related Data Available

Transcripts for DACT3 Gene

Unigene Clusters for DACT3 Gene

Dapper, antagonist of beta-catenin, homolog 3 (Xenopus laevis):
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DACT3 Gene

No ASD Table

Relevant External Links for DACT3 Gene

GeneLoc Exon Structure for
DACT3
ECgene alternative splicing isoforms for
DACT3

Expression for DACT3 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DACT3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DACT3 Gene

This gene is overexpressed in Artery - Tibial (x4.4) and Artery - Aorta (x4.2).

Protein differential expression in normal tissues from HIPED for DACT3 Gene

This gene is overexpressed in Adipocyte (63.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DACT3 Gene



Protein tissue co-expression partners for DACT3 Gene

NURSA nuclear receptor signaling pathways regulating expression of DACT3 Gene:

DACT3

SOURCE GeneReport for Unigene cluster for DACT3 Gene:

Hs.515490

Evidence on tissue expression from TISSUES for DACT3 Gene

  • Skin(4)
genes like me logo Genes that share expression patterns with DACT3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for DACT3 Gene

Orthologs for DACT3 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DACT3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DACT3 34 35
  • 99.1 (n)
dog
(Canis familiaris)
Mammalia DACT3 34 35
  • 92.28 (n)
cow
(Bos Taurus)
Mammalia DACT3 34 35
  • 88.65 (n)
mouse
(Mus musculus)
Mammalia Dact3 34 16 35
  • 83.09 (n)
rat
(Rattus norvegicus)
Mammalia Dact3 34
  • 82.81 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DACT3 35
  • 46 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DACT3 35
  • 38 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii DACT3 (1 of 2) 35
  • 33 (a)
OneToMany
DACT3 (2 of 2) 35
  • 25 (a)
OneToMany
Species where no ortholog for DACT3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DACT3 Gene

ENSEMBL:
Gene Tree for DACT3 (if available)
TreeFam:
Gene Tree for DACT3 (if available)

Paralogs for DACT3 Gene

No data available for Paralogs for DACT3 Gene

Variants for DACT3 Gene

Sequence variations from dbSNP and Humsavar for DACT3 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000002893 -- 46,655,030(+) TAACT(-/A/AA)AAAAA intron-variant, upstream-variant-2KB
rs1000382144 -- 46,652,051(+) ACCAC(A/G)CCTAG intron-variant
rs1000489805 -- 46,658,126(+) AGTAG(C/T)TCACA intron-variant
rs1000541420 -- 46,647,257(+) CTACC(A/C)CACCC downstream-variant-500B
rs1000602364 -- 46,653,948(+) CCTGC(C/T)GCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DACT3 Gene

Variant ID Type Subtype PubMed ID
dgv1789n106 CNV deletion 24896259
nsv1072888 CNV deletion 25765185
nsv828570 CNV gain 20364138
nsv833849 CNV loss 17160897

Variation tolerance for DACT3 Gene

Gene Damage Index Score: 1.75; 33.12% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DACT3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DACT3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DACT3 Gene

Disorders for DACT3 Gene

Relevant External Links for DACT3

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DACT3

No disorders were found for DACT3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DACT3 Gene

Publications for DACT3 Gene

  1. Three Dact gene family members are expressed during embryonic development and in the adult brains of mice. (PMID: 16881060) Fisher D.A. … Cheyette B.N.R. (Dev. Dyn. 2006) 2 3 4 64
  2. DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. (PMID: 18538736) Jiang X. … Yu Q. (Cancer Cell 2008) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  5. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. (PMID: 21718540) Kivimae S. … Cheyette B.N. (BMC Biochem. 2011) 3 64

Products for DACT3 Gene

Sources for DACT3 Gene

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