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Aliases for DACT2 Gene

Aliases for DACT2 Gene

  • Dishevelled Binding Antagonist Of Beta Catenin 2 2 3 5
  • Dapper Antagonist Of Catenin 2 3 4
  • C6orf116 3 4
  • Dapper, Antagonist Of Beta-Catenin, Homolog 2 (Xenopus Laevis) 2
  • Dapper Homolog 2, Antagonist Of Beta-Catenin (Xenopus) 2
  • Dapper, Antagonist Of Beta-Catenin, Homolog 2 3
  • Dapper Homolog 2, Antagonist Of Beta-Catenin 3
  • Chromosome 6 Open Reading Frame 116 2
  • Dapper Homolog 2 3
  • BA503C24.7 3
  • DAPPER2 3
  • DPR2 3

External Ids for DACT2 Gene

Previous HGNC Symbols for DACT2 Gene

  • C6orf116

Previous GeneCards Identifiers for DACT2 Gene

  • GC06M168389
  • GC06M168465
  • GC06M168526
  • GC06M168693
  • GC06M166135

Summaries for DACT2 Gene

GeneCards Summary for DACT2 Gene

DACT2 (Dishevelled Binding Antagonist Of Beta Catenin 2) is a Protein Coding gene. Among its related pathways are TGF-beta receptor signaling (Pathway Interaction Database). GO annotations related to this gene include transcription factor binding and protein kinase C binding. An important paralog of this gene is DACT1.

UniProtKB/Swiss-Prot for DACT2 Gene

  • Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DACT2 Gene

Genomics for DACT2 Gene

Regulatory Elements for DACT2 Gene

Enhancers for DACT2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G168325 1 ENCODE 27.2 -7.1 -7054 2.4 FOXA2 MLX ARID4B DMAP1 ZNF48 SLC30A9 GATA2 SP5 MIER2 PPARG DACT2 LOC105378139
GH06G168369 0.8 ENCODE 22 -50.5 -50540 0.7 ELF3 RB1 MLX CREB3L1 KLF17 ZNF48 RAD21 ZNF143 ZNF391 CREM DACT2 ENSG00000260771 LOC105378139
GH06G168332 0.7 ENCODE 20.9 -14.1 -14081 1.8 CTCF KLF1 ATF1 CBX3 NRF1 ZNF175 ZNF76 ELF4 ELF1 RAD21 DACT2 SMOC2 LOC105378139
GH06G168318 0.7 ENCODE 17 +1.0 1030 1.2 SOX5 SOX13 GATAD2A PKNOX1 FOXA2 SP5 SUZ12 FOXA3 RBBP5 RARA DACT2 LOC105378138
GH06G168333 0.6 ENCODE 17.4 -12.4 -12442 1.2 NCOR1 HLF MAX ZIC2 MAFK ZKSCAN1 DACT2 LOC105378139
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DACT2 on UCSC Golden Path with GeneCards custom track

Promoters for DACT2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000207053 54 601 SUZ12 RBBP5

Genomic Location for DACT2 Gene

Chromosome:
6
Start:
168,292,830 bp from pter
End:
168,319,754 bp from pter
Size:
26,925 bases
Orientation:
Minus strand

Genomic View for DACT2 Gene

Genes around DACT2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DACT2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DACT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DACT2 Gene

Proteins for DACT2 Gene

  • Protein details for DACT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SW24-DACT2_HUMAN
    Recommended name:
    Dapper homolog 2
    Protein Accession:
    Q5SW24
    Secondary Accessions:
    • Q2NKJ2
    • Q569G0
    • Q8WYW2

    Protein attributes for DACT2 Gene

    Size:
    774 amino acids
    Molecular mass:
    82700 Da
    Quaternary structure:
    • Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, CSNK2B, DVL1, DVL2, DVL3, VANGL1, VANGL2, TGFBR1, CTNNB1, CTNND2, CTNND1, LEF1, TCF7, TCF7L1 and HDAC1 (By similarity).
    SequenceCaution:
    • Sequence=AAI11791.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL55843.1; Type=Frameshift; Positions=247; Evidence={ECO:0000305};

    Alternative splice isoforms for DACT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DACT2 Gene

Post-translational modifications for DACT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DACT2 Gene

No data available for DME Specific Peptides for DACT2 Gene

Domains & Families for DACT2 Gene

Protein Domains for DACT2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DACT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5SW24

UniProtKB/Swiss-Prot:

DACT2_HUMAN :
  • The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
  • Belongs to the dapper family.
Domain:
  • The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
Family:
  • Belongs to the dapper family.
genes like me logo Genes that share domains with DACT2: view

No data available for Gene Families for DACT2 Gene

Function for DACT2 Gene

Molecular function for DACT2 Gene

UniProtKB/Swiss-Prot Function:
Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity).

Gene Ontology (GO) - Molecular Function for DACT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding ISS,IBA --
GO:0008013 beta-catenin binding IBA,ISS --
GO:0008134 transcription factor binding ISS --
GO:0051018 protein kinase A binding IBA,ISS --
GO:0070097 delta-catenin binding ISS,IBA --
genes like me logo Genes that share ontologies with DACT2: view
genes like me logo Genes that share phenotypes with DACT2: view

Animal Models for DACT2 Gene

MGI Knock Outs for DACT2:

Animal Model Products

miRNA for DACT2 Gene

miRTarBase miRNAs that target DACT2

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DACT2 Gene

Localization for DACT2 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DACT2 gene
Compartment Confidence
nucleus 3
cytosol 3
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DACT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with DACT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DACT2 Gene

Pathways & Interactions for DACT2 Gene

genes like me logo Genes that share pathways with DACT2: view

Pathways by source for DACT2 Gene

1 BioSystems pathway for DACT2 Gene

SIGNOR curated interactions for DACT2 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DACT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0003382 epithelial cell morphogenesis ISS --
GO:0007162 negative regulation of cell adhesion ISS --
GO:0030111 regulation of Wnt signaling pathway IBA --
GO:0043588 skin development ISS --
genes like me logo Genes that share ontologies with DACT2: view

Drugs & Compounds for DACT2 Gene

No Compound Related Data Available

Transcripts for DACT2 Gene

mRNA/cDNA for DACT2 Gene

(4) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DACT2 Gene

Dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for DACT2 Gene

No ASD Table

Relevant External Links for DACT2 Gene

GeneLoc Exon Structure for
DACT2
ECgene alternative splicing isoforms for
DACT2

Expression for DACT2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DACT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DACT2 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (x8.5), Brain - Nucleus accumbens (basal ganglia) (x8.4), and Brain - Caudate (basal ganglia) (x7.2).

Protein differential expression in normal tissues from HIPED for DACT2 Gene

This gene is overexpressed in Pancreatic juice (62.0) and Placenta (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DACT2 Gene



Protein tissue co-expression partners for DACT2 Gene

NURSA nuclear receptor signaling pathways regulating expression of DACT2 Gene:

DACT2

SOURCE GeneReport for Unigene cluster for DACT2 Gene:

Hs.673059
genes like me logo Genes that share expression patterns with DACT2: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for DACT2 Gene

Orthologs for DACT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DACT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DACT2 34 35
  • 97.24 (n)
dog
(Canis familiaris)
Mammalia DACT2 34 35
  • 70.89 (n)
rat
(Rattus norvegicus)
Mammalia Dact2 34
  • 69.39 (n)
mouse
(Mus musculus)
Mammalia Dact2 34 16 35
  • 68.34 (n)
cow
(Bos Taurus)
Mammalia DACT2 34 35
  • 67.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 45 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
oppossum
(Monodelphis domestica)
Mammalia DACT2 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves DACT2 34 35
  • 55.57 (n)
lizard
(Anolis carolinensis)
Reptilia DACT2 35
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dact2 35
  • 26 (a)
OneToOne
wufe24f12 34
Species where no ortholog for DACT2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DACT2 Gene

ENSEMBL:
Gene Tree for DACT2 (if available)
TreeFam:
Gene Tree for DACT2 (if available)

Paralogs for DACT2 Gene

Paralogs for DACT2 Gene

genes like me logo Genes that share paralogs with DACT2: view

Variants for DACT2 Gene

Sequence variations from dbSNP and Humsavar for DACT2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000054867 -- 168,308,852(+) GGAAC(A/G)AGGGG intron-variant, reference, missense
rs1000084367 -- 168,301,920(+) CTTCA(C/T)TCCCG intron-variant
rs1000269047 -- 168,300,681(+) AGAAT(A/G)TTCTG intron-variant
rs1000298391 -- 168,300,823(+) ATGCT(A/C)AAGAT intron-variant
rs1000304177 -- 168,313,005(+) AGGGG(C/T)CTCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DACT2 Gene

Variant ID Type Subtype PubMed ID
dgv1040e201 CNV deletion 23290073
dgv1041e201 CNV deletion 23290073
dgv1042e201 CNV deletion 23290073
dgv11066n54 CNV gain 21841781
dgv11067n54 CNV loss 21841781
dgv11068n54 CNV loss 21841781
dgv414e215 CNV deletion 23714750
esv1267166 CNV deletion 17803354
esv1464674 CNV insertion 17803354
esv1675508 CNV deletion 17803354
esv2155452 CNV deletion 18987734
esv24045 CNV gain 19812545
esv2618324 CNV deletion 19546169
esv2677427 CNV deletion 23128226
esv2733335 CNV deletion 23290073
esv2733336 CNV deletion 23290073
esv2733337 CNV deletion 23290073
esv2733338 CNV deletion 23290073
esv2733340 CNV deletion 23290073
esv2733341 CNV deletion 23290073
esv2733347 CNV deletion 23290073
esv2759493 CNV gain 17122850
esv27638 CNV gain 19812545
esv4977 CNV loss 18987735
esv8063 CNV loss 19470904
esv989492 CNV deletion 20482838
nsv1073611 CNV deletion 25765185
nsv1112447 CNV deletion 24896259
nsv1112911 CNV deletion 24896259
nsv1118006 CNV deletion 24896259
nsv1147693 CNV insertion 26484159
nsv1153065 CNV deletion 26484159
nsv349216 CNV deletion 16902084
nsv349328 CNV deletion 16902084
nsv511927 CNV loss 21212237
nsv526129 CNV loss 19592680
nsv605460 CNV loss 21841781
nsv605466 CNV loss 21841781
nsv605470 CNV gain 21841781
nsv8007 CNV gain+loss 18304495
nsv820984 CNV deletion 20802225
nsv830867 CNV loss 17160897
nsv949898 CNV deletion 24416366

Variation tolerance for DACT2 Gene

Gene Damage Index Score: 7.32; 81.47% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DACT2 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
DACT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DACT2 Gene

Disorders for DACT2 Gene

Relevant External Links for DACT2

Genetic Association Database (GAD)
DACT2
Human Genome Epidemiology (HuGE) Navigator
DACT2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DACT2

No disorders were found for DACT2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DACT2 Gene

Publications for DACT2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 46 64
  3. Aberrant methylation of DACT1 and DACT2 are associated with tumor progression and poor prognosis in esophageal squamous cell carcinoma. (PMID: 28077137) Guo Y.L. … Kuang G. (J. Biomed. Sci. 2017) 3 64
  4. Methylation of DACT2 accelerates esophageal cancer development by activating Wnt signaling. (PMID: 26919254) Zhang M. … Guo M. (Oncotarget 2016) 3 64
  5. DACT2 is a functional tumor suppressor through inhibiting Wnt/I^-catenin pathway and associated with poor survival in colon cancer. (PMID: 25023701) Wang S. … Yu J. (Oncogene 2015) 3 64

Products for DACT2 Gene

Sources for DACT2 Gene

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