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DACT2 Gene

protein-coding   GIFtS: 49
GCID: GC06M168693

Dishevelled-Binding Antagonist Of Beta-Catenin 2

(Previous names: chromosome 6 open reading frame 116, dapper homolog 2, antagonist...)
(Previous symbol: C6orf116)
  Search for DACT2
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dishevelled-Binding Antagonist Of Beta-Catenin 21 2     Dapper Homolog 2, Antagonist Of Beta-Catenin (Xenopus)1
C6orf1161 2 3     Dapper, Antagonist Of Beta-Catenin, Homolog 2 (Xenopus Laevis)1
Dapper Antagonist Of Catenin 22 3     bA503C24.72
DAPPER22 5     Dapper Homolog 22
DPR22 5     Dapper Homolog 2, Antagonist Of Beta-Catenin2
Chromosome 6 Open Reading Frame 1161     Dapper, Antagonist Of Beta-Catenin, Homolog 22

External Ids:    HGNC: 212311   Entrez Gene: 1680022   Ensembl: ENSG000001644887   OMIM: 6089665   UniProtKB: Q5SW243   

Export aliases for DACT2 gene to outside databases

Previous GC identifers: GC06M168389 GC06M168465 GC06M168526 GC06M166135


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DACT2 Gene:
DACT2 (dishevelled-binding antagonist of beta-catenin 2) is a protein-coding gene. GO annotations related to this gene include protein kinase C binding and transcription factor binding. An important paralog of this gene is DACT1.

UniProtKB/Swiss-Prot: DACT2_HUMAN, Q5SW24
Function: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the
Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May
be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and
restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds
by attenuating TGF-beta signaling (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the DACT2 gene promoter:
         Tal-1   AP-4   Ik-3   Tal-1beta   AREB6   Ik-2   FOXO4   FOXO1a   ITF-2   FOXO1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDACT2 promoter sequence
   Search Chromatin IP Primers for DACT2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DACT2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27   Ensembl cytogenetic band:  6q27   HGNC cytogenetic band: 6q27

DACT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DACT2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M168693:  view genomic region     (about GC identifiers)

Start:
168,693,510 bp from pter      End:
168,720,434 bp from pter
Size:
26,925 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DACT2_HUMAN, Q5SW24 (See protein sequence)
Recommended Name: Dapper homolog 2  
Size: 774 amino acids; 82700 Da
Subunit: Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit,
PKC-type kinase, CSNK2B, DVL1, DVL2, DVL3, VANGL1, VANGL2, TGFBR1, CTNNB1, CTNND2, CTNND1, LEF1, TCF7, TCF7L1 and
HDAC1 (By similarity)
Sequence caution: Sequence=AAI11791.1; Type=Erroneous initiation; Sequence=AAL55843.1; Type=Frameshift;
Positions=247;
Secondary accessions: Q2NKJ2 Q569G0 Q8WYW2
Alternative splicing: 4 isoforms:  Q5SW24-1   Q5SW24-2   Q5SW24-3   Q5SW24-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DACT2: NX_Q5SW24

Explore proteomics data for DACT2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DACT2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001273279.1  NP_001273280.1  NP_999627.2  

    ENSEMBL proteins: 
     ENSP00000355761   ENSP00000355760   ENSP00000476573   ENSP00000476434  

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    Search eBioscience for ELISAs for DACT2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR024843 Dapper
     IPR024853 Dact2

    Graphical View of Domain Structure for InterPro Entry Q5SW24

    ProtoNet protein and cluster: Q5SW24

    UniProtKB/Swiss-Prot: DACT2_HUMAN, Q5SW24
    Domain: The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family
    proteins (By similarity)
    Similarity: Belongs to the dapper family


    Find genes that share domains with DACT2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DACT2_HUMAN, Q5SW24
    Function: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the
    Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May
    be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and
    restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds
    by attenuating TGF-beta signaling (By similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding ISS--
    GO:0005515protein binding ----
    GO:0008013beta-catenin binding ISS--
    GO:0008134transcription factor binding ISS--
    GO:0051018protein kinase A binding ISS--
         
    Find genes that share ontologies with DACT2           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for DACT2:
     Increased cell number in G2M,  

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Dact2):
     homeostasis/metabolism  integument 

    Find genes that share phenotypes with DACT2           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Dact2tm1.1Xya for DACT2

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DACT2
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    miRNA
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    hsa-mir-128-3p (MIRT022027), hsa-mir-193b-3p (MIRT041542)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytosol2
    mitochondrion2
    extracellular1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IEA--

    Find genes that share ontologies with DACT2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DACT2 About    
    See pathways by source

    SuperPathContained pathways About
    1TGF-beta receptor signaling
    TGF-beta receptor signaling


    1 BioSystems Pathway for DACT2
        TGF-beta receptor signaling



        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DACT2
    Interactions:

        Search GeneGlobe Interaction Network for DACT2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    Selected Interacting proteins for DACT2 (ENSP000003557604) via UniProtKB, MINT, STRING, and/or I2D (see all 9)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    DVL2ENSP000000053404STRING: ENSP00000005340
    DVL1ENSP000003681694STRING: ENSP00000368169
    DVL3ENSP000003160544STRING: ENSP00000316054
    CTNNB1ENSP000003444564STRING: ENSP00000344456
    TGFB1ENSP000002219304STRING: ENSP00000221930
    About this table

    Gene Ontology (GO): 5 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003382epithelial cell morphogenesis ISS--
    GO:0007162negative regulation of cell adhesion ISS--
    GO:0043588skin development ISS--
    GO:0072061inner medullary collecting duct development ISS--
    GO:1900108negative regulation of nodal signaling pathway ISS--

    Find genes that share ontologies with DACT2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DACT2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DACT2 gene (3 alternative transcripts): 
    NM_001286350.1  NM_001286351.1  NM_214462.4  

    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000366796 ENST00000366795(uc003qwq.3) ENST00000610183 ENST00000607983

    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat DACT2
      QuantiFast Probe-based Assays in human, mouse, rat DACT2

    10 AceView cDNA sequences:

    CR624566 BX377941 AF318336 NM_214462 BI052777 AW629887 AW150833 CF994844 
    BI769958 BX329974 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DACT2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATCTCAAATA
    DACT2 Expression
    About this image


    DACT2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 7) fully expand
     
     Gut Tube (Gastrointestinal Tract)    fully expand to see all 2 entries
             Foregut
     
     Primitive Streak (Early Embryonic Tissues)
             Primitive streak-like cells
     
     Neurons
             Glycinergic Amacrine Cells Inner Nuclear Layer
     
     Bone (Muscoskeletal System)
             Mandibular Process
     
     Endoderm (Gastrulation Derivatives)
             Definitive endoderm-like cells
    DACT2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DACT2 Protein Expression
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for DACT2 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dact21 , 5 dapper homolog 2, antagonist of beta-catenin (xenopus)1, 5 68.34(n)1
    59.65(a)1
      17 (8.95 cM)5
    2400251  NM_172826.31  NP_766414.31 
     141952315 
    chicken
    (Gallus gallus)
    Aves DACT21 dapper, antagonist of beta-catenin, homolog 2 (Xenopus more 55.57(n)
    47(a)
      421561  XM_419602.4  XP_419602.4 
    lizard
    (Anolis carolinensis)
    Reptilia DACT26
    dishevelled-binding antagonist of beta-catenin 2
    34(a)
    1 ↔ 1
    1(224625963-224644378)
    zebrafish
    (Danio rerio)
    Actinopterygii wufe24f122 Danio rerio Frodo2 (frd2) mRNA, complete cds 72.67(n)    AY208969.2 


    ENSEMBL Gene Tree for DACT2 (if available)
    TreeFam Gene Tree for DACT2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DACT2 gene
    DACT12  

    Find genes that share paralogs with DACT2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DACT2 (see all 436)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1453974151,2
    --166149096(+) TTTCCA/GAGATT 1 -- int10--------
    rs1484729051,2
    C--166149127(+) TTTGA-/TTCTTT
            
    TTTCT
    1 -- int10--------
    rs1999060571,2
    C--166149129(+) TGATTC/TTTTTT 1 -- int10--------
    rs2008977841,2
    C--166149130(+) GATTCC/TTTTTT 1 -- int10--------
    rs94560551,2
    C,A--166149133(+) tctttC/Tttctt 1 -- int1 trp33Minor allele frequency- T:0.00NA WA CSA 5
    rs122059311,2
    --166149161(+) tcttcC/Ttcttc 1 -- int1 trp30--------
    rs122059331,2
    --166149167(+) tcttcC/Ttcttc 1 -- int10--------
    rs47087141,2
    C,H--168707127(+) CCCCTT/CTTTTT 1 -- ds5001 trp36Minor allele frequency- C:0.01NA WA EA 130
    rs69401451,2
    C,A,H--168707161(+) TCTGTT/AGCCCA 1 -- ds50011Minor allele frequency- A:0.50NA 2
    rs1138756311,2
    C,F--168707162(+) CTGTAG/CCCCAA 1 -- ds50012Minor allele frequency- C:0.50WA NA 4

    HapMap Linkage Disequilibrium report for DACT2 (168693510 - 168720434 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DACT2 (see all 23):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv1088e201CNV Deletion23290073
    dgv1087e201CNV Deletion23290073
    esv2733340CNV Deletion23290073
    esv4977CNV Deletion18987735
    esv2155452CNV Deletion18987734
    dgv1089e201CNV Deletion23290073
    nsv820984CNV Deletion20802225
    esv2618324CNV Deletion19546169
    esv1675508CNV Deletion17803354
    esv2733341CNV Deletion23290073

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DACT2
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608966    OMIM disorders: --


    Find genes that share disorders with DACT2           About GenesLikeMe

    Genetic Association Database (GAD): DACT2
    Human Genome Epidemiology (HuGE) Navigator: DACT2 (2 documents)

    Export disorders for DACT2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DACT2 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with DACT2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits. (PubMed id 23754948)1 Randall J.C....Heid I.M. (PLoS Genet. 2013)
    4. Reduced expression of DACT2 promotes hepatocellular carcinoma progression: involvement of methylation-mediated gene silencing. (PubMed id 23496880)1 Gao S....Zheng S.S. (World J Surg Oncol 2013)
    5. Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer. (PubMed id 22806826)1 Jia Y....Guo M. (J. Pathol. 2013)
    6. DACT2 is a candidate tumor suppressor and prognostic marker in esophageal squamous cell carcinoma. (PubMed id 23803417)1 Hou J....Xu L.Y. (Cancer Prev Res (Phila) 2013)
    7. Relationships among MTHFR a1298c gene polymorphisms and methylation status of Dact1 gene in transitional cell carcinomas. (PubMed id 23244112)1 Cheng H....Chen J.C. (Asian Pac. J. Cancer Prev. 2012)
    8. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. (PubMed id 21718540)1 Kivimae S.... Cheyette B.N. (BMC Biochem. 2011)
    9. Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different pathway from the polypoid adenoma-carcinoma sequence. (PubMed id 18370954)1 Koga Y....Tsuneyoshi M. (Histopathology 2008)
    10. Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)2 Wan D....Gu J. (Proc. Natl. Acad. Sci. U.S.A. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 168002 HGNC: 21231 AceView: DACT2 Ensembl:ENSG00000164488 euGenes: HUgn168002
    ECgene: DACT2 H-InvDB: DACT2

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DACT2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DACT2 gene:
    Search GeneIP for patents involving DACT2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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