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Aliases for DACT2 Gene

Aliases for DACT2 Gene

  • Dishevelled-Binding Antagonist Of Beta-Catenin 2 2 3
  • Dapper Antagonist Of Catenin 2 3 4
  • C6orf116 3 4
  • DAPPER2 3 6
  • DPR2 3 6
  • Dapper, Antagonist Of Beta-Catenin, Homolog 2 (Xenopus Laevis) 2
  • Dapper Homolog 2, Antagonist Of Beta-Catenin (Xenopus) 2
  • Dapper, Antagonist Of Beta-Catenin, Homolog 2 3
  • Dapper Homolog 2, Antagonist Of Beta-Catenin 3
  • Chromosome 6 Open Reading Frame 116 2
  • Dapper Homolog 2 3
  • BA503C24.7 3

External Ids for DACT2 Gene

Previous HGNC Symbols for DACT2 Gene

  • C6orf116

Previous GeneCards Identifiers for DACT2 Gene

  • GC06M168389
  • GC06M168465
  • GC06M168526
  • GC06M168693
  • GC06M166135

Summaries for DACT2 Gene

GeneCards Summary for DACT2 Gene

DACT2 (Dishevelled-Binding Antagonist Of Beta-Catenin 2) is a Protein Coding gene. Among its related pathways are TGF-beta receptor signaling. GO annotations related to this gene include transcription factor binding and protein kinase C binding. An important paralog of this gene is DACT1.

UniProtKB/Swiss-Prot for DACT2 Gene

  • Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DACT2 Gene

Genomics for DACT2 Gene

Regulatory Elements for DACT2 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DACT2 Gene

Start:
168,292,830 bp from pter
End:
168,319,754 bp from pter
Size:
26,925 bases
Orientation:
Minus strand

Genomic View for DACT2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DACT2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DACT2 Gene

Proteins for DACT2 Gene

  • Protein details for DACT2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SW24-DACT2_HUMAN
    Recommended name:
    Dapper homolog 2
    Protein Accession:
    Q5SW24
    Secondary Accessions:
    • Q2NKJ2
    • Q569G0
    • Q8WYW2

    Protein attributes for DACT2 Gene

    Size:
    774 amino acids
    Molecular mass:
    82700 Da
    Quaternary structure:
    • Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, CSNK2B, DVL1, DVL2, DVL3, VANGL1, VANGL2, TGFBR1, CTNNB1, CTNND2, CTNND1, LEF1, TCF7, TCF7L1 and HDAC1 (By similarity).
    SequenceCaution:
    • Sequence=AAI11791.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAL55843.1; Type=Frameshift; Positions=247; Evidence={ECO:0000305};

    Alternative splice isoforms for DACT2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DACT2 Gene

Proteomics data for DACT2 Gene at MOPED

Post-translational modifications for DACT2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DACT2 Gene

No data available for DME Specific Peptides for DACT2 Gene

Domains for DACT2 Gene

Protein Domains for DACT2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DACT2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5SW24

UniProtKB/Swiss-Prot:

DACT2_HUMAN :
  • Q5SW24
Domain:
  • The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins.
Family:
  • Belongs to the dapper family.
genes like me logo Genes that share domains with DACT2: view

No data available for Gene Families for DACT2 Gene

Function for DACT2 Gene

Molecular function for DACT2 Gene

UniProtKB/Swiss-Prot Function: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating TGF-beta signaling (By similarity).

Gene Ontology (GO) - Molecular Function for DACT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding ISS --
GO:0005515 protein binding --
GO:0008013 beta-catenin binding ISS --
GO:0008134 transcription factor binding ISS --
GO:0051018 protein kinase A binding ISS --
genes like me logo Genes that share ontologies with DACT2: view

Phenotypes for DACT2 Gene

MGI mutant phenotypes for DACT2:
inferred from 1 alleles
GenomeRNAi human phenotypes for DACT2:
genes like me logo Genes that share phenotypes with DACT2: view

Animal Models for DACT2 Gene

MGI Knock Outs for DACT2:

Animal Model Products

CRISPR Products

miRNA for DACT2 Gene

miRTarBase miRNAs that target DACT2

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DACT2

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DACT2 Gene

Localization for DACT2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DACT2 Gene COMPARTMENTS Subcellular localization image for DACT2 gene
Compartment Confidence
nucleus 3
cytosol 2
mitochondrion 2
extracellular 1

Gene Ontology (GO) - Cellular Components for DACT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IEA --
genes like me logo Genes that share ontologies with DACT2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DACT2 Gene

Pathways for DACT2 Gene

SuperPathways for DACT2 Gene

Superpath Contained pathways
1 TGF-beta receptor signaling
genes like me logo Genes that share pathways with DACT2: view

Pathways by source for DACT2 Gene

1 BioSystems pathway for DACT2 Gene

Interacting Proteins for DACT2 Gene

Gene Ontology (GO) - Biological Process for DACT2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
GO:0003382 epithelial cell morphogenesis ISS --
GO:0007162 negative regulation of cell adhesion ISS --
GO:0043588 skin development ISS --
GO:0072061 inner medullary collecting duct development ISS --
genes like me logo Genes that share ontologies with DACT2: view

Transcripts for DACT2 Gene

mRNA/cDNA for DACT2 Gene

(4) Additional mRNA sequences :
(5) REFSEQ mRNAs :
(10) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DACT2 Gene

Dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DACT2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DACT2

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DACT2 Gene

No ASD Table

Relevant External Links for DACT2 Gene

GeneLoc Exon Structure for
DACT2
ECgene alternative splicing isoforms for
DACT2

Expression for DACT2 Gene

mRNA expression in normal human tissues for DACT2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DACT2 Gene

This gene is overexpressed in Brain - Putamen (basal ganglia) (8.5), Brain - Nucleus accumbens (basal ganglia) (8.4), and Brain - Caudate (basal ganglia) (7.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DACT2 Gene

SOURCE GeneReport for Unigene cluster for DACT2 Gene Hs.673059

genes like me logo Genes that share expressions with DACT2: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for DACT2 Gene

Orthologs for DACT2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DACT2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DACT2 35
  • 97.24 (n)
  • 96.32 (a)
DACT2 36
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DACT2 35
  • 67.43 (n)
  • 57.03 (a)
DACT2 36
  • 51 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DACT2 35
  • 70.89 (n)
  • 60.64 (a)
DACT2 36
  • 59 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dact2 35
  • 68.34 (n)
  • 59.65 (a)
Dact2 16
Dact2 36
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DACT2 36
  • 38 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 42 (a)
ManyToMany
-- 36
  • 45 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Dact2 35
  • 69.39 (n)
  • 61.39 (a)
chicken
(Gallus gallus)
Aves DACT2 35
  • 55.57 (n)
  • 47 (a)
DACT2 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DACT2 36
  • 34 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii dact2 36
  • 26 (a)
OneToOne
wufe24f12 35
Species with no ortholog for DACT2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DACT2 Gene

ENSEMBL:
Gene Tree for DACT2 (if available)
TreeFam:
Gene Tree for DACT2 (if available)

Paralogs for DACT2 Gene

Paralogs for DACT2 Gene

genes like me logo Genes that share paralogs with DACT2: view

Variants for DACT2 Gene

Sequence variations from dbSNP and Humsavar for DACT2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs899519 -- 168,311,117(-) AGGGG(C/G)AGGCA intron-variant
rs967039 -- 168,304,557(-) CCAGG(C/T)ACCAC intron-variant
rs1056439 -- 168,298,461(-) GGTGT(G/T)TACTT intron-variant
rs1056442 -- 168,298,192(-) GGATG(A/T)CTGCT intron-variant
rs1466458 -- 168,296,763(+) CAACT(C/T)TTTAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DACT2 Gene

Variant ID Type Subtype PubMed ID
dgv2034e1 CNV Complex 17122850
nsv886962 CNV Loss 21882294
nsv830867 CNV Loss 17160897
nsv886983 CNV Loss 21882294
dgv7044n71 CNV Loss 21882294
nsv526129 CNV Loss 19592680
nsv8007 CNV Gain+Loss 18304495
esv2733338 CNV Deletion 23290073
esv2618324 CNV Deletion 19546169
esv2733340 CNV Deletion 23290073
esv2155452 CNV Deletion 18987734
nsv349328 CNV Loss 16902084
esv8063 CNV Loss 19470904
esv2733341 CNV Deletion 23290073
esv27638 CNV Gain 19812545
nsv820984 CNV Deletion 20802225
dgv1087e201 CNV Deletion 23290073
dgv1088e201 CNV Deletion 23290073
nsv511927 CNV Loss 21212237
esv4977 CNV Deletion 18987735
esv1675508 CNV Deletion 17803354
esv2733347 CNV Deletion 23290073
dgv1089e201 CNV Deletion 23290073

Relevant External Links for DACT2 Gene

HapMap Linkage Disequilibrium report
DACT2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DACT2 Gene

Disorders for DACT2 Gene

Relevant External Links for DACT2

Genetic Association Database (GAD)
DACT2
Human Genome Epidemiology (HuGE) Navigator
DACT2
genes like me logo Genes that share disorders with DACT2: view

No data available for UniProtKB/Swiss-Prot for DACT2 Gene

Publications for DACT2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48
  2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3 48
  3. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. (PMID: 21718540) Kivimae S. … Cheyette B.N. (BMC Biochem. 2011) 3
  4. Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer. (PMID: 22806826) Jia Y. … Guo M. (J. Pathol. 2013) 3
  5. Relationships among MTHFR a1298c gene polymorphisms and methylation status of Dact1 gene in transitional cell carcinomas. (PMID: 23244112) Cheng H. … Chen J.C. (Asian Pac. J. Cancer Prev. 2012) 3

Products for DACT2 Gene

Sources for DACT2 Gene

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