DACT2 Gene
protein-coding GIFtS: 41
GC06M168526
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dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)
(Previous names: chromosome 6 open reading frame 116, dapper homolog 2, antagonist of beta-catenin (xenopus) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: C6orf116)
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Aliases &
Descriptions
for DACT2
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase)
About This Section
|
| Aliases |
|---|
| C6orf116 2, 3 | | DAPPER2 2 | | DPR2 2 | | FLJ31232 2 | | MGC133141 2 | | MGC133142 2 | | RP11-503C24.7 2 | | bA503C24.7 1, 2 |
| | | Descriptions |
|---|
| chromosome 6 open reading frame 116 1 | | dapper homolog 2, antagonist of beta-catenin 2 | | dapper homolog 2, antagonist of beta-catenin (xenopus) 1 | | dapper, antagonist of beta-catenin, homolog 2 2 | dapper, antagonist of beta-catenin, homolog 2 (Xenopus
laevis) 2 |
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Search outside databases for aliases for DACT2 genePrevious GC identifers: GC06M168389 GC06M168465 |
Summaries
for DACT2(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| UniProtKB/Swiss-Prot: DACT2_HUMAN, Q5SW24Function: Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal
degradation of Nodal receptors (By similarity) |
Genomic Location
for DACT2
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences)
About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
 Transcription factor binding sites upstream to the DACT2 gene 
Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27DACT2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06M168526:
(about GC identifiers)
Start:
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168,436,361 bp from pter |
End:
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168,463,283 bp from pter |
Size:
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26,923 bases |
Orientation:
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minus strand |
RefSeq DNA sequence:- NC_000006.10 NT_007302.13
| Proteins
for DACT2
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: DACT2_HUMAN, Q5SW24 (See
protein sequence)Recommended Name: Dapper homolog 2 Size: 774 amino acids; 82700 Da
Sequence caution: Sequence=AAL55843.1; Type=Frameshift; Positions=247;
Secondary accessions: Q2NKJ2 Q569G0 Q8WYW2Alternative splicing: 4 isoforms: Q5SW24-1 Q5SW24-2 Q5SW24-3 Q5SW24-4 REFSEQ proteins: NP_999627.2
ENSEMBL proteins: ENSP00000355761 ENSP00000355760
Human Recombinant Proteins  Browse Origene for full length recombinant human proteins expressed in human HEK293 cells
Antibodies for DACT2:
Assays for DACT2: | Protein
Domains/
Families
for DACT2(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q5SW24 UniProtKB/Swiss-Prot: DACT2_HUMAN, Q5SW24Domain: The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH
(Dishevelled) family proteins (By similarity)Similarity: Belongs to the dapper family | Gene Function
for DACT2
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_214462
 Applied Biosystems Silencer® siRNAs for DACT2
 Sigma-Aldrich siRNA for DACT2
Sigma-Aldrich shRNA for DACT2
Explore Sigma-Aldrich super-pooled esiRNAs
OriGene GFP tagged cDNA clone in CMV expression vector: NM_214462
Myc/DDK tagged cDNA clone in CMV expression vector: NM_214462
untagged cDNA clones in CMV expression vector (see all 2): NM_214462
Primers:  Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
OriGene genome-wide validated SYBR primer pairs: NM_214462
UniProtKB/Swiss-Prot: DACT2_HUMAN, Q5SW24Function: Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal
degradation of Nodal receptors (By similarity)2 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Dact2):
| Pathways & Interactions
for DACT2
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
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5/10 Interacting proteins for DACT2 (ENSP000003557603) via UniProtKB, MINT, and/or STRING (see all 10
)About this table
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Drugs & Compounds
for DACT2(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
 Browse Tocris compounds for DACT2
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Transcripts
for DACT2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene,
Expression Assays from Applied Biosystems)
About This Section
| OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_214462
Sigma-Aldrich siRNA for DACT2
Sigma-Aldrich shRNA for DACT2
Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer® siRNAs: NM_214462 REFSEQ mRNAs for DACT2 gene: NM_214462.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_214462
OriGene GFP tagged cDNA clone in CMV expression vector: NM_214462
Myc/DDK tagged cDNA clone in CMV expression vector: NM_214462
untagged cDNA clones in CMV expression vector (see all 2): NM_214462
Additional cDNA sequence: BC092498.1 4 DOTS entries: DT.95284991 DT.95290084 DT.121309291 DT.121309299 10 AceView cDNA sequences:CR624566 BI052777 BX377941 NM_214462 AF318336 AW629887 CF994844 AW150833 BI769958 BX329974
 highest scoring ESTs for DACT2:AF318336 CF994844 AW150833 AW629887 BC092498 BI052777 BI769958 NM_214462 BC111764 BC111790 Unigene Clusters for DACT2: Dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis) Hs.673059 [show with all ESTs], Hs.716274 [show with all ESTs]Unigene Representative Sequences: AF318336, BC092498
GeneLoc Exon Structure
2 Ensembl transcripts including schematic representations: ENST00000366796
ENST00000366795
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Expression
for DACT2
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| DACT2 expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for DACT2
1 / 2 / 3 1 probe-set matching DACT2 gene Data from
(Publications) and GNF BioGPS
About these images
About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene clusters: Hs.673059 Hs.716274
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Orthologs
for DACT2
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for DACT2 gene from 5 species
| Organism |
Gene |
Locus |
Description |
Human
Similarity |
NCBI accessions |
chimpanzee
(Pan troglodytes) |
DACT21 |
-- |
dapper, antagonist of beta-catenin, homolog 2 (Xenopus more |
98.82(n)
98.36(a) |
742130 XM_001145122.1 XP_001145122.1 |
rat
(Rattus norvegicus) |
Dact21 |
-- |
dapper, antagonist of beta-catenin, homolog 2 (Xenopus more |
67.69(n)
56.42(a) |
308212 XM_218002.4 XP_218002.4 |
mouse
(Mus musculus) |
Dact21, 5 |
175
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dapper homolog 2, antagonist of beta-catenin (xenopus)1, 5 |
67.9(n)1
54.42(a)1 |
2400251 NM_172826.21 NP_766414.21
AK0138215 AK0416045 (see all 14) |
chicken
(Gallus gallus) |
DACT21 |
-- |
dapper, antagonist of beta-catenin, homolog 2 (Xenopus more |
56.85(n)
51.03(a) |
421561 XM_419602.2 XP_419602.2 |
zebrafish
(Danio rerio) |
wufe24f122 |
-- |
Danio rerio Frodo2 (frd2) mRNA, complete cds |
72.67(n) |
AY208969.2 |
About this table Species with no ortholog for DACT2
ENSEMBL Gene Tree for DACT2 | Paralogs
for DACT2(Paralogs according to 1HomoloGene
and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
About This Section
| Paralogs for DACT2 gene
- DACT12 DACT32
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SNPs/Variants
for DACT2(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
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HapMap Linkage Disequilibrium images for DACT2 (up to first 250kb)
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Disorders & Mutations
for DACT2
(in which this Gene is Involved, According to
OMIM, UniProtKB,
PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
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OMIM: 608966
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Medical News
for DACT2(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications
for DACT2 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 8 PubMed articles for DACT2 gene: |
Search for DACT2
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing DACT2
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing DACT2
(According to HUGE)
About This Section
| -- |
Specialized Databases showing DACT2(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
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| About This Section
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| Services
for DACT2(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section
| 
Products for DACT2:
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Incremental update: 13 Oct 2009
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