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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DACT2 Gene

protein-coding GIFtS: 49
GCID: GC06M168693

dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)

(Previous names: chromosome 6 open reading frame 116, dapper homolog 2,...)
(Previous symbol: C6orf116)

Explore 2 diseases affiliated with
DACT2 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dapper, Antagonist Of Beta-Catenin, Homolog 2 (Xenopus Laevis)¹ ²		Chromosome 6 Open Reading Frame 116¹
C6orf116¹ ² ³		Dapper Homolog 2, Antagonist Of Beta-Catenin (Xenopus)¹
BA503C24.7¹		RP11-503C24.7²
Dapper Antagonist Of Catenin 2² ³		Dapper Homolog 2²
DAPPER2² ⁵		Dapper Homolog 2, Antagonist Of Beta-Catenin²
DPR2² ⁵

External Ids:	HGNC: 21231¹	Entrez Gene: 168002²	Ensembl: ENSG00000164488⁷	OMIM: 608966⁵	UniProtKB: Q5SW24³

Export aliases for DACT2 gene to outside databases

Previous GC identifers: GC06M168389 GC06M168465 GC06M168526 GC06M166135

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: DACT2_HUMAN, Q5SW24

Function: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal

signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved

in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining

their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating

TGF-beta signaling (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_025741.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DACT2 gene promoter:
Tal-1 AP-4 Ik-3 Tal-1beta AREB6 Ik-2 FOXO4 FOXO1a ITF-2 FOXO1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DACT2 promoter sequence

Search SABiosciences Chromatin IP Primers for DACT2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DACT2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q27 Ensembl cytogenetic band: 6q27 HGNC cytogenetic band: 6q27

DACT2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DACT2 gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M168693: view genomic region (about GC identifiers)

Start:	168,693,512 bp from pter	End:	168,720,434 bp from pter
Size:	26,923 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DACT2_HUMAN, Q5SW24 (See protein sequence)

Recommended Name: Dapper homolog 2

Size: 774 amino acids; 82700 Da

Subunit: Can form homodimers and heterodimers with DACT1 or DACT3. Interacts with CSNK1D, PKA catalytic subunit,

PKC-type kinase, CSNK2B, DVL1, DVL2, DVL3, VANGL1, VANGL2, TGFBR1, CTNNB1, CTNND2, CTNND1, LEF1, TCF7, TCF7L1 and

HDAC1 (By similarity)

Sequence caution: Sequence=AAI11791.1; Type=Erroneous initiation; Sequence=AAL55843.1; Type=Frameshift; Positions=247;

Secondary accessions: Q2NKJ2 Q569G0 Q8WYW2

Alternative splicing: 4 isoforms: Q5SW24-1 Q5SW24-2 Q5SW24-3 Q5SW24-4 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DACT2: NX_Q5SW24

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q5SW24

DACT2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_999627.2

ENSEMBL proteins:

ENSP00000355760 ENSP00000355761

Human Recombinant Protein Products for DACT2:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DACT2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005739	mitochondrion	IEA	--

DACT2 for ontologies About GeneDecksing

DACT2 Antibody Products:

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	Uscn ELISAs and CLIAs for DACT2

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DACT2 for domains About GeneDecksing

2 InterPro domains/families:

IPR024843 Dapper

IPR024853 Dact2

Graphical View of Domain Structure for InterPro Entry Q5SW24

ProtoNet protein and cluster: Q5SW24

UniProtKB/Swiss-Prot: DACT2_HUMAN, Q5SW24

Domain: The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family

proteins (By similarity)

Similarity: Belongs to the dapper family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DACT2_HUMAN, Q5SW24

Function: Involved in regulation of intracellular signaling pathways during development. Negatively regulates the Nodal

signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors, such as TGFBR1. May be involved

in control of the morphogenetic behavior of kidney ureteric bud cells by keeping cells epithelial and restraining

their mesenchymal character. May play an inhibitory role in the re-epithelialization of skin wounds by attenuating

TGF-beta signaling (By similarity)

Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005080	protein kinase C binding	ISS	--
GO:0008013	beta-catenin binding	ISS	--
GO:0008134	transcription factor binding	ISS	--
GO:0051018	protein kinase A binding	ISS	--
GO:0070097	delta-catenin binding	ISS	--

DACT2 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for DACT2:

Increased cell number in G2M,

2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Dact2):

homeostasis/metabolism

integument

DACT2 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Dact2^tm1.1Xya for DACT2

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DACT2

miRNA Products:		OriGene 3'-UTR Clone: DACT2 Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DACT2
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate DACT2
		SwitchGear 3'UTR luciferase reporter plasmid: DACT2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DACT2 (see all 7) OriGene shRNA RFP: DACT2 OriGene siRNA: DACT2
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		Sirion Biotech Custom design and validation of potent shRNA sequences against DACT2

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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DACT2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DACT2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DACT2 (NM_214462)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for DACT2
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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACT2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TGF-beta receptor signaling

TGF-beta receptor signaling

1.00

1 BioSystems Pathway for DACT2

TGF-beta receptor signaling

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for DACT2

STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

5/6 Interacting proteins for DACT2 (ENSP00000355760⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
VANGL1	ENSP00000310800⁴	STRING: ENSP00000310800
VANGL2	ENSP00000357040⁴	STRING: ENSP00000357040
DVL3	ENSP00000316054⁴	STRING: ENSP00000316054
DVL1	ENSP00000368169⁴	STRING: ENSP00000368169
CTNND1	ENSP00000382004⁴	STRING: ENSP00000382004

About this table

Gene Ontology (GO): 5 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003382	epithelial cell morphogenesis	ISS	--
GO:0007162	negative regulation of cell adhesion	ISS	--
GO:0043588	skin development	ISS	--
GO:0072061	inner medullary collecting duct development	ISS	--
GO:1900108	negative regulation of nodal signaling pathway	ISS	--

DACT2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DACT2
Search CenterWatch for drugs/clinical trials and news about DACT2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DACT2 gene:

NM_214462.3

Unigene Cluster for DACT2:

Dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)

Hs.673059 [show with all ESTs]

Unigene Representative Sequence: AF318336

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000366795(uc003qwq.3) ENST00000366796

miRNA Products:		OriGene 3'-UTR Clone: DACT2 Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DACT2
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DACT2 (see all 7) OriGene shRNA RFP: DACT2 OriGene siRNA: DACT2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DACT2
		Sirion Biotech Custom design and validation of potent shRNA sequences against DACT2

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DACT2 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DACT2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: DACT2 (NM_214462)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for DACT2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DACT2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DACT2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DACT2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DACT2

Additional cDNA sequence:

AF318336.1 BC092498.1 BC111764.1 BC111790.1

4 DOTS entries:

DT.95284991 DT.95290084 DT.121309291 DT.121309299

10 AceView cDNA sequences:

CR624566 NM_214462 BI052777 AF318336 BX377941 AW629887 AW150833 CF994844

BX329974 BI769958

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DACT2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATCTCAAATA

About this image

DACT2 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Gut Tube

Midgut

Midgut Endoderm Cells

Endoderm

Gut Tube

Midgut

Gut Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Definitive endoderm-like cells (Generation of mesend...)

Mesendoderm-like cells (Generation of mesend...)

Definitive endoderm-like cells (A scalable, suspensi...)

See DACT2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DACT2

SOURCE GeneReport for Unigene cluster: Hs.673059

SABiosciences Custom PCR Arrays for DACT2

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for DACT2 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DACT2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DACT2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACT2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for DACT2 gene from 3/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DACT2¹	dapper, antagonist of beta-catenin, homolog 2 (Xenopus more	56.02(n) 46.58(a)		421561 XM_419602.3 XP_419602.3
lizard (Anolis carolinensis)	Reptilia	DACT2⁶	--	37(a)	1 ↔ 1	1(224640033-224644378)
zebrafish (Danio rerio)	Actinopterygii	wufe24f12²	Danio rerio Frodo2 (frd2) mRNA, complete cds	72.67(n)		AY208969.2

ENSEMBL Gene Tree for DACT2 (if available)
TreeFam Gene Tree for DACT2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DACT2 gene

DACT1² DACT3²

DACT2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs9456053^1,2	A	--	166145350(+)	`ATCTCA/GGCAGC`	1	--	int¹		0	--	--	--	--
rs4708714^1,2	C,H	--	168707127(+)	`CCCCTT/CTTTTT`	1	--	ds500¹ trp³		6		NA WA EA	130
rs6940145^1,2	C,A,H	--	168707161(+)	`TCTGTT/AGCCCA`	1	--	ds500¹		1		NA	2
rs113875631^1,2	C,F	--	168707162(+)	`CTGTAG/CCCCAA`	1	--	ds500¹		2		WA NA	4
rs10945496^1,2	C,F,A,H	--	168707167(+)	`GCCCAG/AGCTGG`	1	--	ds500¹		4		NA WA CSA	7
rs191412966^1,2		--	168707184(+)	`GTGGCA/GCAATC`	1	--	ds500¹		0	--	--	--	--
rs181104388^1,2		--	168707218(+)	`CCTGGC/GTTCAA`	1	--	ds500¹		0	--	--	--	--
rs61347395^1,2	C	--	168707289(+)	`TTTTTT/-GTATT`	1	--	ds500¹		1		NA	2
rs10945497^1,2	C,F,A,H	--	168707320(+)	`AGAGAT/CGGGGT`	1	--	ds500¹		4		NA WA CSA	7
rs59468907^1,2		--	168707353(+)	`TCTTGA/GTCTTC`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for DACT2 (168693512 - 168720434 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 10 variations for DACT2
10 CNVs: 99807 43379 69670 32851 3654 23789 62599 44240 6527 31315

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DACT2

DNA2.0 Custom Variant and Variant Library Synthesis for DACT2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DACT2 for disorders           About GeneDecksing

OMIM gene information: 608966    OMIM disorders: --

2 diseases for DACT2:    About MalaCards

adenoma carcinoma

Human Genome Epidemiology (HuGE) Navigator: DACT2 (2 documents)

Export disorders for DACT2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for DACT2 gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with DACT2)

Utopia: connect your pdf to the dynamic
world of online information

All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. (PubMed id 21718540)¹ Kivimae S....Cheyette B.N. (2011)
Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)¹ Rose J.E....Uhl G.R. (2010)
Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)¹ Hendrickson S.L....O'Brien S.J. (2010)
Flat adenoma-carcinoma sequence with high-malignancy potential as demonstrated by CD10 and beta-catenin expression: a different pathway from the polypoid adenoma-carcinoma sequence. (PubMed id 18370954)¹ Koga Y....Tsuneyoshi M. (2008)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Large-scale cDNA transfection screening for genes related to cancer development and progression. (PubMed id 15498874)² Wan D....Gu J. (2004)
The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)² Mungall A.J.... Beck S. (2003)
Identification and characterization of human DAPPER1 and DAPPER2 genes in silico. (PubMed id 12632086)¹ Katoh M. and Katoh M. (2003)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. (PubMed id 10737800)¹ Dias Neto E....Simpson A.J.G. (2000)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 168002	HGNC: 21231	AceView: DACT2	Ensembl:ENSG00000164488	euGenes: HUgn168002
ECgene: DACT2	H-InvDB: DACT2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DACT2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DACT2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DACT2 gene:
Search GeneIP for patents involving DACT2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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DACT2 Gene

dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)

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DACT2 Gene

dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)

Aliasesfor DACT2 gene

Summariesfor DACT2 gene

Genomic Viewsfor DACT2 gene

Proteinsfor DACT2 gene

Protein Domains /Familiesfor DACT2 gene

Functionfor DACT2 gene

Pathways & Interactionsfor DACT2 gene

Drugs & Compoundsfor DACT2 gene

Transcriptsfor DACT2 gene

Expression for DACT2 gene

Orthologsfor DACT2 gene

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Genomic Variantsfor DACT2 gene

Disorders / Diseasesfor DACT2 gene

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Genome Databases showing DACT2 gene

Other Databases showing DACT2 gene

Specialized Databases showing DACT2 gene

Intellectual Propertyfor DACT2 gene

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Aliases
for DACT2 gene

Summaries
for DACT2 gene

Genomic Views
for DACT2 gene

Proteins
for DACT2 gene

Protein Domains /
Families
for DACT2 gene

Function
for DACT2 gene

Pathways & Interactions
for DACT2 gene

Drugs & Compounds
for DACT2 gene

Transcripts
for DACT2 gene

Expression
for DACT2 gene

Orthologs
for DACT2 gene

Paralogs
for DACT2 gene

Genomic Variants
for DACT2 gene

Disorders / Diseases
for DACT2 gene

Publications
for DACT2 gene

Intellectual Property
for DACT2 gene

Products
for DACT2 gene