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Aliases & Descriptions for DACT1
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases DAPPER 1 , 2 DAPPER1 1 , 2 DPR1 2 , 3 FRODO 1 , 2 HDPR1 1 , 2 HNG3 3 OTTHUMP00000179031 2 THYEX3 1 , 2 hDPR1 3
Descriptions Hepatocellular carcinoma novel gene 3 protein 3 dapper 1 2 dapper homolog 1, antagonist of beta-catenin 2 dapper homolog 1, antagonist of beta-catenin (xenopus) 1 dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) 2 heptacellular carcinoma novel gene 3 2
Search outside databases for aliases for DACT1 genePrevious GC identifers: GC14P052900 GC14P057090 GC14P057094
Summaries for DACT1 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0 Function : Positively regulates DVL2-mediated signaling pathways during development. Binds to DVL2and impedes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptionalactivation of target genes of the Wnt signaling pathway (By similarity)
Genomic Location for DACT1
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the DACT1 gene Entrez Gene cytogenetic band: 14q23.1 Ensembl cytogenetic band: 14q23.1 HGNC cytogenetic band: 14q22.3 DACT1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome 14 GeneLoc Exon Structure
GeneLoc location for GC14P058174:
(about GC identifiers )
Start:
58,170,555 bp from pter
End:
58,184,792 bp from pter
Size:
14,238 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000014.7 NT_026437.11 Proteins for DACT1
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0 (See
protein sequence )Recommended Name: Dapper homolog 1 Size : 836 amino acids; 90174 Da
Subunit : Interacts with DVL2 (By similarity)
Subcellular location : Cytoplasm (By similarity). Nucleus (By similarity)
Secondary accessions : Q86TY0
REFSEQ proteins (2 alternative transcripts):
NP_001072988.1 NP_057735.2 ENSEMBL proteins: ENSP00000337439 ENSP00000378582 ENSP00000378581 Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: DACT1 2 Gene Ontology (GO) cellular component terms (links to tree view) :
About this table Antibodies for DACT1: Assays for DACT1:
Protein
Domains/ Families for DACT1(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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ProtoNet protein and cluster: Q9NYF0
UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0 Domain : The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH(Dishevelled) family proteins (By similarity) Similarity : Belongs to the dapper family
Gene Function for DACT1
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
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SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_016651 Applied Biosystems Silencer ® siRNAs for DACT1 Sigma-Aldrich siRNA for DACT1 Sigma-Aldrich shRNA for DACT1 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001079520                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001079520                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001079520  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_016651 UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0 Function : Positively regulates DVL2-mediated signaling pathways during development. Binds to DVL2and impedes the degradation of CTNNB1/beta-catenin, thereby enhancing the transcriptionalactivation of target genes of the Wnt signaling pathway (By similarity)
Pathways & Interactions for DACT1
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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Gene Network CentralTM Interacting Genes and Proteins Network for DACT1 5/14 Interacting proteins for DACT1 (ENSP00000337439 3 ) via UniProtKB, MINT, and/or STRING (see all 14
)About this table 2 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0007275 multicellular organismal development
IEA -- GO:0016055 Wnt receptor signaling pathway
IEA --
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Drugs & Compounds for DACT1 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for DACT1
Transcripts for DACT1(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
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siRNAs from Applied Biosystems ,
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shRNA from
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2 ): NM_016651 Sigma-Aldrich siRNA for DACT1 Sigma-Aldrich shRNA for DACT1 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001079520 NM_016651
REFSEQ mRNAs for DACT1 gene (2 alternative transcripts): NM_001079520.1 NM_016651.5
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001079520 NM_016651
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2 ): NM_001079520                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 2 ): NM_001079520                                  untagged cDNA clones in CMV expression vector (see all 2 ): NM_001079520  
Additional cDNA sequence: AF251079.2 AK299879.1 AK316164.1 AK316169.1 AK316237.1 AK316423.1 AY603415.1 BX161433.1 CR610675.1
7 DOTS entries : DT.452996 DT.100733609 DT.100664518 DT.100758021 DT.102826367 DT.120784866 DT.100705246
24/85 AceView cDNA sequences (see all 85
):BM722965 AA236657 BX441943 AA977500 AA953515 AA724806 BX112130 AU279699 BQ007981 BU678380 AI375466 AA779757 CR610675 BK000256 AI699673 BX161433 NM_016651 BU742074 AA410372 AI216037 BM923155 BM677426 AI633645 BX356369
highest scoring ESTs for DACT1 :AA129658 AA010881 AA129683 AA236657 AA350933 AA351473 AA406240 AA410372 AA421570 AA449288
Unigene Cluster for DACT1: Dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis) Hs.48950 [show with all ESTs ] Unigene Representative Sequence: NM_016651 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for DACT1 ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c SP1 :   -               SP2 :           -       SP3 :                
About this scheme ECgene alternative splicing isoforms for DACT1 3 Ensembl transcripts including schematic representations : ENST00000335867
ENST00000395153
ENST00000395151
Expression for DACT1
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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DACT1 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for DACT1 1 / 2 / 3
3 probe-sets matching DACT1 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: --SOURCE GeneReport for Unigene cluster: Hs.48950
Orthologs for DACT1
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for DACT1 gene from 5/7 species (see all 7
)
Organism
Gene
Locus
Description
Human Similarity
NCBI accessions
chimpanzee (Pan troglodytes)
DACT11
--
dapper, antagonist of beta-catenin, homolog 1 (Xenopus more
99.44(n) 99.4(a)
452938 XM_001165895.1 XP_001165895.1
rat (Rattus norvegicus)
Dact11
--
dapper, antagonist of beta-catenin, homolog 1 (Xenopus more
83.37(n) 82.8(a)
500666 XM_576044.2 XP_576044.1
mouse (Mus musculus)
Dact11 , 5
125
dapper homolog 1, antagonist of beta-catenin (xenopus)1, 5
82.93(n) 1 83.14(a) 1
59036 1 NM_021532.3 1 NP_067507.2 1 AF251078 5 AF488775 5 (see all 18 )
chicken (Gallus gallus)
DACT11
--
dapper, antagonist of beta-catenin, homolog 1 (Xenopus more
72.19(n) 71.87(a)
723789 NM_001044692.1 NP_001038157.1
zebrafish (Danio rerio)
dact11
--
dapper homolog 1, antagonist of beta-catenin (xenopus)
56.86(n) 52.69(a)
405799 NM_214731.2 NP_999896.2
About this table Species with no ortholog for DACT1 ENSEMBL Gene Tree for DACT1 Paralogs for DACT1 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for DACT1 gene DACT2 2 DACT3 2
SNPs/Variants for DACT1 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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The following additional 42 SNP(s) have been
found in Applied Biosystems data source:(Click
for
Applied Biosystems TaqMan ® Genotyping Assay ) HapMap Linkage Disequilibrium images for DACT1 (up to first 250kb)
Disorders & Mutations for DACT1
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 607861
Medical News for DACT1 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for DACT1 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10/11 PubMed articles for DACT1 gene (see all 11
): Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. (PubMed id 11970895) 2, 3, 4 Cheyette B.N.R.... Moon R.T. (2002) The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121) 3, 4 Heilig R.... Weissenbach J. (2003) Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network. (PubMed id 19073771) 1, 3 Lagathu C....Sethi J.K. (2009) HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. (PubMed id 15580286) 1, 3 Yau T.O....Ng I.O. (2005) Identification and characterization of human DAPPER1 and DAPPER2 genes in silico. (PubMed id 12632086) 1, 3 Katoh M. and Katoh M. (2003) Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. (PubMed id 18936100) 3 Gao X....Chen Y.G. (2008) Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. (PubMed id 16446366) 3 Zhang L....Chen Y.G. (2006) The consensus coding sequences of human breast and colorectal cancers. (PubMed id 16959974) 4 Sjoeblom T.... Velculescu V.E. (2006) Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197) 3 Brandenberger R.... Stanton L.W. (2004) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 3 Bonaldo M.F....Soares M.B. (1996)
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Genome Databases showing DACT1
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing DACT1
(According to HUGE )
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--
Specialized Databases showing DACT1 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for DACT1 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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