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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DACT1 Gene

protein-coding   GIFtS: 49
GCID: GC14P059100

dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)

(Previous names: dapper homolog 1, antagonist of beta-catenin (xenopus)...)
 Explore 7 diseases affiliated with
DACT1 via
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Biological research products
for DACT1    

Aliases
for DACT1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dapper, Antagonist Of Beta-Catenin, Homolog 1 (Xenopus Laevis)1 2     Dapper Antagonist Of Catenin 12 3
DAPPER11 2 5     Hepatocellular Carcinoma Novel Gene 3 Protein2 3
FRODO1 2 5     Dapper Homolog 1, Antagonist Of Beta-Catenin (Xenopus)1
DPR12 3 5     Dapper Homolog 12
DAPPER1 2     Heptacellular Carcinoma Novel Gene 32
HDPR11 2     HNG33
THYEX31 2     HDPR11 2

External Ids:    HGNC: 177481   Entrez Gene: 513392   Ensembl: ENSG000001656177   OMIM: 6078615   UniProtKB: Q9NYF03   

Export aliases for DACT1 gene to outside databases

Previous GC identifers: GC14P052900 GC14P057090 GC14P057094 GC14P058174 GC14P039268


Summaries
for DACT1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DACT1:
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at
the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during
development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice
lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript
variants have been found for this gene. (provided by RefSeq, Jan 2012)

UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0
Function: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a
role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family
proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate
the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt
signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane
localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the
function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis
at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling
and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may
prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress
transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation.
During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and
establishment of spines




Genomic Views
for DACT1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DACT1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   ATF-2   CUTL1   E2F-2   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DACT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DACT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DACT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q22.3

DACT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DACT1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P059100:  view genomic region     (about GC identifiers)

Start:
 59,100,685 bp from pter      End:
 59,115,039 bp from pter
Size:
 14,355 bases      Orientation:
 plus strand

Proteins
for DACT1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0 (See protein sequence)
Recommended Name: Dapper homolog 1  
Size: 836 amino acids; 90174 Da
Subunit: Can form homodimers and heterodimers with DACT2 or DACT3. Interacts with CSNK1D, PKA catalytic subunit,
PKC-type kinase, CSNK2A1, CSNK2B, DVL1, DVL3, VANGL1, VANGL2, CTNND1 and HDAC1 (By similarity). Interacts with DVL2.
Interacts with YWHAB; the interaction is enhanced by PKA phosphorylating DACT1 at Ser-237 and Ser-827. Interacts with
CTNNB1 and HDAC1. Interacts with GSK3B; the interaction is indicative for an association of DACT1 with the
beta-catenin destruction complex. Interacts with GSK3A
Subcellular location: Cytoplasm. Nucleus. Cell junction, synapse (By similarity). Note=Shuttles between the nucleus and
the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence
Sequence caution: Sequence=AAF65569.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAD61905.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8MYJ2 Q86TY0
Alternative splicing: 2 isoforms:  Q9NYF0-1   Q9NYF0-2   

Explore the universe of human proteins at neXtProt for DACT1: NX_Q9NYF0

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9NYF0

    • DACT1 Protein expression data from MOPED and PaxDb:    About this image 
    DACT1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001072988.1  NP_057735.2  

    ENSEMBL proteins: 
     ENSP00000451598   ENSP00000404297   ENSP00000378581   ENSP00000378582   ENSP00000337439  
     ENSP00000442850  

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    Novus Biologicals DACT1 Protein
    Novus Biologicals DACT1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DACT1

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA--
    GO:0030054cell junction IEA--
    GO:0030877colocalizes with beta-catenin destruction complex IDA--
    GO:0045202synapse IEA--

    DACT1 for ontologies           About GeneDecksing



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    Uscn ELISAs and CLIAs for DACT1

    Protein Domains /
    Families
    for DACT1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DACT1 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR024843 Dapper
     IPR024848 Dact1

    Graphical View of Domain Structure for InterPro Entry Q9NYF0

    ProtoNet protein and cluster: Q9NYF0

    UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0
    Domain: The C-terminal PDZ-binding motif mediates interaction with the PDZ domains of DSH (Dishevelled) family proteins
    (By similarity)
    Similarity: Belongs to the dapper family


    Function
    for DACT1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DACT1_HUMAN, Q9NYF0
    Function: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a
    role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family
    proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate
    the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt
    signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane
    localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the
    function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis
    at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling
    and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may
    prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress
    transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation.
    During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and
    establishment of spines

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding ISS--
    GO:0005515protein binding IPI--
    GO:0008013beta-catenin binding IDA--
    GO:0051018protein kinase A binding IDA--
    GO:0070097delta-catenin binding ISS--
         
    DACT1 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 5 alleles) (MGI details for Dact1):
     cardiovascular system  digestive/alimentary  embryogenesis  growth/size  limbs/digits/tail 
     mortality/aging  nervous system  no phenotypic analysis  renal/urinary system  reproductive system 
     skeleton 

    DACT1 for phenotypes           About GeneDecksing

    Animal Models:
         Mouse knock-outs for DACT1: Dact1tm1.3Bnrc Dact1tm1.1Bnrc Dact1tm1Yegc
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DACT1 

    miRNA
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    hsa-miR-429 hsa-miR-25 hsa-miR-30d hsa-miR-29b-1* hsa-miR-30a hsa-miR-124 hsa-miR-649 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmid: DACT1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DACT1 (see all 4)
    OriGene shRNA RFP: DACT1
    OriGene siRNA: DACT1
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    Sirion Biotech Custom design and validation of potent shRNA sequences against DACT1 

    Gene Editing
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    Clone
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    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACT1


    Pathways & Interactions
    for DACT1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DACT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/25 Interacting proteins for DACT1 (Q9NYF01, 2, 3 ENSP000003374394) via UniProtKB, MINT, STRING, and/or I2D (see all 25)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C7orf25Q9BPX72, 3MINT-8249997 I2D: score=2 
    CSNK2BP678702, 3MINT-8253209 I2D: score=2 
    SH3GL2Q999622, 3MINT-8270396 I2D: score=2 
    TK1P041832, 3MINT-8273235 I2D: score=2 
    MYCP011063, ENSP000003672074I2D: score=1 STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 5/20 biological process terms (GO ID links to tree view) (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA18936100
    GO:0001702gastrulation with mouth forming second IEA--
    GO:0007275multicellular organismal development ----
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030177positive regulation of Wnt receptor signaling pathway IDA--

    DACT1 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DACT1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DACT1
    Search CenterWatch for drugs/clinical trials and news about DACT1 

    Transcripts
    for DACT1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DACT1 gene (2 alternative transcripts): 
    NM_001079520.1  NM_016651.5  

    Unigene Cluster for DACT1:

    Dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
    Hs.48950  [show with all ESTs]
    Unigene Representative Sequence: NM_016651
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555845 ENST00000556859 ENST00000421793 ENST00000395151 ENST00000395153(uc010trv.2 uc001xdw.3 uc001xdx.3 uc010trw.2)
    ENST00000335867 ENST00000541264

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    hsa-miR-429 hsa-miR-25 hsa-miR-30d hsa-miR-29b-1* hsa-miR-30a hsa-miR-124 hsa-miR-649 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmid: DACT1 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DACT1 (see all 4)
    OriGene shRNA RFP: DACT1
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    Clone
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    Primer
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    Additional cDNA sequence: 

    AF251079.2 AK299879.1 AK316164.1 AK316169.1 AK316237.1 AK316423.1 AY603415.1 BX161433.1 
    NR_046093.1 NR_046095.1 

    7 DOTS entries:

    DT.452996  DT.100733609  DT.100664518  DT.100758021  DT.102826367  DT.120784866  DT.100705246 

    24/85 AceView cDNA sequences (see all 85):

    BX161433 BU678380 NM_016651 BM722965 AA779757 AU279699 AA977500 AA236657 
    AI375466 BX441943 BU742074 BK000256 AI699673 CR610675 BX112130 AA724806 
    AA953515 BQ007981 BM677426 AA410372 AI216037 BM923155 AW665830 BX356367 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DACT1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
    SP1:        -                                       
    SP2:                                -               
    SP3:                                                


    ECgene alternative splicing isoforms for DACT1

    Expression
    for DACT1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DACT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    DACT1 Expression
    About this image

    DACT1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    Paraxial MesodermParaxial MesodermParaxial Mesoderm CellsMesoderm
    KidneyMetanephrosKidney
    Lower Urinary TractUreterLower Urinary Tract
    Reproductive SystemMesonephrosReproductive System
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 7 LifeMap Cells 
    NameCategory
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ mesenchymal progenitor E15 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ progenitor E69 (Embryonic Progenitor Cell)
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    Embryoid bodies (Generation of adipoc...)

    See DACT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DACT1

    SOURCE GeneReport for Unigene cluster: Hs.48950
        SABiosciences Custom PCR Arrays for DACT1
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACT1

    Orthologs
    for DACT1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for DACT1 gene from 4/12 species (see all 12)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DACT11 dapper, antagonist of beta-catenin, homolog 1 (Xenopus more 72.19(n)
    71.87(a)    		   723789  NM_001044692.1  NP_001038157.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DACT16
    		 --
    		 66(a)
    		 1 ↔ 1
    		 GL343459.1(588845-615095)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.76022 Xenopus laevis dapper 1 mRNA, complete cds 78.4(n)    AF488776.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii dact11 dapper homolog 1, antagonist of beta-catenin (xenopus) 56.86(n)
    52.69(a)    		   405799  NM_214731.2  NP_999896.2 


    ENSEMBL Gene Tree for DACT1 (if available)
    TreeFam Gene Tree for DACT1 (if available) 

    Paralogs
    for DACT1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DACT1 gene
    DACT32  DACT22  

    DACT1 for paralogs           About GeneDecksing



    Genomic Variants
    for DACT1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/293 NCBI SNPs in DACT1 are shown (see all 293)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs775877871,2
    		F--39263830(+) TGTATT/CCCCAG 1 -- us2k11Minor allele frequency- C:0.11WA 118
    rs1179252691,2
    		C,F--39263986(+) TAAATT/GTAGAT 1 -- us2k11Minor allele frequency- G:0.03NA 120
    rs1134099511,2
    		--39264322(+) CTTCCG/AGACTC 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs2012734971,2
    		C--39264741(-) AGTGGC/TTTTTT 1 -- us2k10--------
    rs759350791,2
    		F--39264782(+) GAAATC/GAAATC 1 -- us2k11Minor allele frequency- G:0.09WA 118
    rs570189781,2
    		C,F--39265023(+) GAGCCT/CCTTGA 1 -- nc-transcript-variant4Minor allele frequency- C:0.33WA CSA 124
    rs793957581,2
    		C,F--39265488(+) ATCCCA/GGACCC 1 -- int11Minor allele frequency- G:0.10WA 118
    rs774783691,2
    		--39265731(+) TTGGTA/GGGGGT 1 -- int10--------
    rs1170323801,2
    		C,F--39265865(+) AGACTC/ATTTTT 1 -- int11Minor allele frequency- A:0.03EA 120
    rs1158388841,2
    		C,F--39266154(+) GTAGGC/TGATCA 1 -- int11Minor allele frequency- T:0.04WA 118

    HapMap Linkage Disequilibrium report for DACT1 (59100685 - 59115039 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for DACT1: --
    Human Gene Mutation Database (HGMD): DACT1

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DACT1
    DNA2.0 Custom Variant and Variant Library Synthesis for DACT1

    Disorders / Diseases
    for DACT1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DACT1 for disorders           About GeneDecksing

    OMIM gene information: 607861    OMIM disorders: --

    UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0
  • Defects in DACT1 may be a cause of susceptibility to neural tube defects (NTD) [MIM:182940]. NTD are
    • congenital malformations of the central nervous system and adjacent structures related to defective neural tube
    closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the
    embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure
    of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both
    genetic and environmental components

    7 diseases for DACT1:    About MalaCards
    hepatocellular carcinoma    carcinoma    renal agenesis    colorectal cancer
    lung cancer    cerebritis    esophagitis

    Human Genome Epidemiology (HuGE) Navigator: DACT1 (2 documents)

    Export disorders for DACT1 gene to outside databases

    Publications
    for DACT1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DACT1 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with DACT1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. (PubMed id 11970895)1, 2, 3 Cheyette B.N.R.... Moon R.T. (2002)
    2. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. (PubMed id 15580286)1, 2, 9 Yau T.O....Ng I.O. (2005)
    3. Oncogenic function of DACT1 in colon cancer through th e regulation of b-catenin. (PubMed id 22470507)1, 2 Yuan G....Fu W. (2012)
    4. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. (PubMed id 21718540)1, 2 Kivimae S....Cheyette B.N. (2011)
    5. Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation. (PubMed id 21262972)1, 2 Chen H....Chen Y.G. (2011)
    6. Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. (PubMed id 18936100)1, 2 Gao X....Chen Y.G. (2008)
    7. The evolutionally conserved activity of Dapper2 in ant agonizing TGF-beta signaling. (PubMed id 17197390)1, 2 Su Y....Chen Y.G. (2007)
    8. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. (PubMed id 16446366)1, 2 Zhang L....Chen Y.G. (2006)
    9. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    10. Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network. (PubMed id 19073771)1, 9 Lagathu C....Sethi J.K. (2009)

    External Searches for DACT1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    Genome Databases showing DACT1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51339 HGNC: 17748 AceView: DACT1 Ensembl:ENSG00000165617 euGenes: HUgn51339
    ECgene: DACT1 H-InvDB: DACT1

    Other Databases showing DACT1 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DACT1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DACT1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DACT1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DACT1 gene:
    Search GeneIP for patents involving DACT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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