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Aliases for DACT1 Gene

Aliases for DACT1 Gene

  • Dishevelled-Binding Antagonist Of Beta-Catenin 1 2 3
  • DPR1 3 4 6
  • Hepatocellular Carcinoma Novel Gene 3 Protein 3 4
  • Dapper Antagonist Of Catenin 1 3 4
  • DAPPER1 3 6
  • HDPR1 3 4
  • FRODO 3 6
  • Dapper, Antagonist Of Beta-Catenin, Homolog 1 (Xenopus Laevis) 2
  • Dapper Homolog 1, Antagonist Of Beta-Catenin (Xenopus) 2
  • Dapper, Antagonist Of Beta-Catenin, Homolog 1 3
  • Heptacellular Carcinoma Novel Gene 3 3
  • Dapper Homolog 1 3
  • DAPPER 3
  • THYEX3 3
  • HNG3 4

External Ids for DACT1 Gene

Previous GeneCards Identifiers for DACT1 Gene

  • GC14P052900
  • GC14P057090
  • GC14P057094
  • GC14P058174
  • GC14P059100
  • GC14P039268

Summaries for DACT1 Gene

Entrez Gene Summary for DACT1 Gene

  • The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for DACT1 Gene

DACT1 (Dishevelled-Binding Antagonist Of Beta-Catenin 1) is a Protein Coding gene. Diseases associated with DACT1 include craniorachischisis and occipital encephalocele. GO annotations related to this gene include beta-catenin binding and protein kinase A binding. An important paralog of this gene is DACT2.

UniProtKB/Swiss-Prot for DACT1 Gene

  • Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DACT1 Gene

Genomics for DACT1 Gene

Regulatory Elements for DACT1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DACT1 Gene

Start:
58,633,967 bp from pter
End:
58,648,321 bp from pter
Size:
14,355 bases
Orientation:
Plus strand

Genomic View for DACT1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DACT1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DACT1 Gene

Proteins for DACT1 Gene

  • Protein details for DACT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYF0-DACT1_HUMAN
    Recommended name:
    Dapper homolog 1
    Protein Accession:
    Q9NYF0
    Secondary Accessions:
    • A8MYJ2
    • Q86TY0

    Protein attributes for DACT1 Gene

    Size:
    836 amino acids
    Molecular mass:
    90174 Da
    Quaternary structure:
    • Can form homodimers and heterodimers with DACT2 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, CSNK2A1, CSNK2B, DVL1, DVL3, VANGL1, VANGL2, CTNND1 and HDAC1 (By similarity). Interacts with DVL2. Interacts with YWHAB; the interaction is enhanced by PKA phosphorylating DACT1 at Ser-237 and Ser-827. Interacts with CTNNB1 and HDAC1. Interacts with GSK3B; the interaction is indicative for an association of DACT1 with the beta-catenin destruction complex. Interacts with GSK3A.
    SequenceCaution:
    • Sequence=AAF65569.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD61905.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DACT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DACT1 Gene

Proteomics data for DACT1 Gene at MOPED

Post-translational modifications for DACT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DACT1 Gene

No data available for DME Specific Peptides for DACT1 Gene

Domains for DACT1 Gene

Protein Domains for DACT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DACT1 Gene

Graphical View of Domain Structure for InterPro Entry

Q9NYF0

UniProtKB/Swiss-Prot:

DACT1_HUMAN :
  • Q9NYF0
Domain:
  • The C-terminal PDZ-binding motif mediates interaction with the PDZ domains of DSH (Dishevelled) family proteins.
Family:
  • Belongs to the dapper family.
genes like me logo Genes that share domains with DACT1: view

No data available for Gene Families for DACT1 Gene

Function for DACT1 Gene

Molecular function for DACT1 Gene

UniProtKB/Swiss-Prot Function: Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.

Gene Ontology (GO) - Molecular Function for DACT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005080 protein kinase C binding ISS --
GO:0005515 protein binding IPI 16446366
GO:0008013 beta-catenin binding IDA 18936100
GO:0051018 protein kinase A binding IDA 21262972
GO:0070097 delta-catenin binding ISS --
genes like me logo Genes that share ontologies with DACT1: view
genes like me logo Genes that share phenotypes with DACT1: view

Animal Models for DACT1 Gene

MGI Knock Outs for DACT1:

Animal Model Products

CRISPR Products

miRNA for DACT1 Gene

miRTarBase miRNAs that target DACT1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DACT1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DACT1 Gene

Localization for DACT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DACT1 Gene

Cytoplasm. Nucleus. Cell junction, synapse. Note=Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DACT1 Gene COMPARTMENTS Subcellular localization image for DACT1 gene
Compartment Confidence
nucleus 5
cytosol 2
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for DACT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA 16446366
GO:0005829 cytosol TAS --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with DACT1: view

Pathways for DACT1 Gene

SuperPathways for DACT1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DACT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 18936100
GO:0001702 gastrulation with mouth forming second IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0030177 positive regulation of Wnt signaling pathway IDA 21262972
GO:0030178 negative regulation of Wnt signaling pathway IMP 18936100
genes like me logo Genes that share ontologies with DACT1: view

No data available for Pathways by source for DACT1 Gene

Transcripts for DACT1 Gene

Unigene Clusters for DACT1 Gene

Dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis):
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DACT1

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for DACT1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DACT1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: -
SP3:

Relevant External Links for DACT1 Gene

GeneLoc Exon Structure for
DACT1
ECgene alternative splicing isoforms for
DACT1

Expression for DACT1 Gene

mRNA expression in normal human tissues for DACT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DACT1 Gene

SOURCE GeneReport for Unigene cluster for DACT1 Gene Hs.48950

genes like me logo Genes that share expressions with DACT1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for DACT1 Gene

Orthologs for DACT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DACT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DACT1 35
  • 99.44 (n)
  • 99.4 (a)
DACT1 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DACT1 35
  • 84.31 (n)
  • 82.71 (a)
DACT1 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DACT1 35
  • 83.49 (n)
  • 80.7 (a)
DACT1 36
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dact1 35
  • 83.33 (n)
  • 83.05 (a)
Dact1 16
Dact1 36
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia DACT1 36
  • 76 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DACT1 36
  • 53 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dact1 35
  • 83.37 (n)
  • 82.8 (a)
chicken
(Gallus gallus)
Aves DACT1 35
  • 71.64 (n)
  • 70.75 (a)
DACT1 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DACT1 36
  • 64 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.7602 35
tropical clawed frog
(Silurana tropicalis)
Amphibia dact1 35
  • 66.25 (n)
  • 65.04 (a)
Str.3375 35
zebrafish
(Danio rerio)
Actinopterygii dact1 35
  • 56.99 (n)
  • 52.72 (a)
dact1 36
  • 47 (a)
OneToOne
Species with no ortholog for DACT1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DACT1 Gene

ENSEMBL:
Gene Tree for DACT1 (if available)
TreeFam:
Gene Tree for DACT1 (if available)

Paralogs for DACT1 Gene

Paralogs for DACT1 Gene

genes like me logo Genes that share paralogs with DACT1: view

Variants for DACT1 Gene

Sequence variations from dbSNP and Humsavar for DACT1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs11541 -- 58,648,052(-) ACATA(C/G)GATCA utr-variant-3-prime, nc-transcript-variant
rs150722 -- 58,639,721(+) ATATT(A/C)ATATG intron-variant
rs160469 -- 58,637,611(+) GTCGC(A/G)GCCCC upstream-variant-2KB, intron-variant
rs160470 -- 58,642,413(+) cagga(A/G)gtaga intron-variant
rs160471 -- 58,642,438(+) gagat(G/T)ggacc intron-variant

Relevant External Links for DACT1 Gene

HapMap Linkage Disequilibrium report
DACT1
Human Gene Mutation Database (HGMD)
DACT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for DACT1 Gene

Disorders for DACT1 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (4) Diseases for DACT1 Gene including...

Search for DACT1 Gene in MalaCards »

UniProtKB/Swiss-Prot

DACT1_HUMAN
  • Neural tube defects (NTD) [MIM:182940]: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. {ECO:0000269 PubMed:22610794}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for DACT1

Genetic Association Database (GAD)
DACT1
Human Genome Epidemiology (HuGE) Navigator
DACT1
genes like me logo Genes that share disorders with DACT1: view

Publications for DACT1 Gene

  1. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. (PMID: 15580286) Yau T.O. … Ng I.O. (Oncogene 2005) 3 4 23
  2. Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. (PMID: 11970895) Cheyette B.N.R. … Moon R.T. (Dev. Cell 2002) 2 3 4
  3. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4
  4. Dapper 1 antagonizes Wnt signaling by promoting dishevelled degradation. (PMID: 16446366) Zhang L. … Chen Y.G. (J. Biol. Chem. 2006) 3 4
  5. The evolutionally conserved activity of Dapper2 in antagonizing TGF- beta signaling. (PMID: 17197390) Su Y. … Chen Y.-G. (FASEB J. 2007) 3 4

Products for DACT1 Gene

Sources for DACT1 Gene

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