Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



DACT1 Gene

protein-coding   GIFtS: 51
GCID: GC14P059100

Dishevelled-Binding Antagonist Of Beta-Catenin 1

(Previous names: dapper homolog 1, antagonist of beta-catenin (xenopus),...)
  See DACT1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Dishevelled-Binding Antagonist Of Beta-Catenin 11 2     DAPPER2
DPR12 3 5     HDPR12
Dapper Antagonist Of Catenin 12 3     THYEX32
Hepatocellular Carcinoma Novel Gene 3 Protein2 3     Dapper Homolog 12
DAPPER12 5     Dapper, Antagonist Of Beta-Catenin, Homolog 12
FRODO2 5     Heptacellular Carcinoma Novel Gene 32
Dapper Homolog 1, Antagonist Of Beta-Catenin (Xenopus)1     HNG33
Dapper, Antagonist Of Beta-Catenin, Homolog 1 (Xenopus Laevis)1     hDPR13

External Ids:    HGNC: 177481   Entrez Gene: 513392   Ensembl: ENSG000001656177   OMIM: 6078615   UniProtKB: Q9NYF03   

Export aliases for DACT1 gene to outside databases

Previous GC identifers: GC14P052900 GC14P057090 GC14P057094 GC14P058174 GC14P039268


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for DACT1 Gene:
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif
at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during
development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and
mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced
transcript variants have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for DACT1 Gene:
DACT1 (dishevelled-binding antagonist of beta-catenin 1) is a protein-coding gene. Diseases associated with DACT1 include craniorachischisis, and occipital encephalocele. GO annotations related to this gene include protein kinase A binding and beta-catenin binding. An important paralog of this gene is DACT2.

UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0
Function: Involved in regulation of intracellular signaling pathways during development. Specifically thought to
play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled)
family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to
regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target
genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity.
Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a
lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB.
Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems
to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP)
pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to
LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in
positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory
synapse organization, and dendrite formation and establishment of spines




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NT_026437.13  NC_018925.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DACT1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   ATF-2   CUTL1   E2F-2   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDACT1 promoter sequence
   Search Chromatin IP Primers for DACT1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DACT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q22.3

DACT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DACT1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P059100:  view genomic region     (about GC identifiers)

Start:
59,100,685 bp from pter      End:
59,115,039 bp from pter
Size:
14,355 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0 (See protein sequence)
Recommended Name: Dapper homolog 1  
Size: 836 amino acids; 90174 Da
Subunit: Can form homodimers and heterodimers with DACT2 or DACT3. Interacts with CSNK1D, PKA catalytic subunit,
PKC-type kinase, CSNK2A1, CSNK2B, DVL1, DVL3, VANGL1, VANGL2, CTNND1 and HDAC1 (By similarity). Interacts with
DVL2. Interacts with YWHAB; the interaction is enhanced by PKA phosphorylating DACT1 at Ser-237 and Ser-827.
Interacts with CTNNB1 and HDAC1. Interacts with GSK3B; the interaction is indicative for an association of DACT1
with the beta-catenin destruction complex. Interacts with GSK3A
Sequence caution: Sequence=AAF65569.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAD61905.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8MYJ2 Q86TY0
Alternative splicing: 2 isoforms:  Q9NYF0-1   Q9NYF0-2   

Explore the universe of human proteins at neXtProt for DACT1: NX_Q9NYF0

Explore proteomics data for DACT1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DACT1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001072988.1  NP_057735.2  

    ENSEMBL proteins: 
     ENSP00000451598   ENSP00000404297   ENSP00000378582   ENSP00000337439   ENSP00000442850  
    Reactome Protein details: Q9NYF0

    DACT1 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for DACT1
    GenScript Custom Purified and Recombinant Proteins Services for DACT1
    Novus Biologicals DACT1 Protein
    Novus Biologicals DACT1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DACT1

     
    Search eBioscience for Proteins for DACT1 

    DACT1 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    OriGene Antibodies for DACT1
    OriGene Custom Antibody Services for DACT1
    Novus Biologicals DACT1 Antibodies
    Abcam antibodies for DACT1
    Cloud-Clone Corp. Antibodies for DACT1
    ThermoFisher Antibodies for DACT1
    LSBio Antibodies in human, mouse, rat for DACT1

    DACT1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DACT1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DACT1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DACT1
    Cloud-Clone Corp. CLIAs for DACT1
    Search eBioscience for ELISAs for DACT1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    2 InterPro protein domains:
     IPR024843 Dapper
     IPR024848 Dact1

    Graphical View of Domain Structure for InterPro Entry Q9NYF0

    ProtoNet protein and cluster: Q9NYF0

    UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0
    Domain: The C-terminal PDZ-binding motif mediates interaction with the PDZ domains of DSH (Dishevelled) family
    proteins (By similarity)
    Similarity: Belongs to the dapper family


    Find genes that share domains with DACT1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DACT1_HUMAN, Q9NYF0
    Function: Involved in regulation of intracellular signaling pathways during development. Specifically thought to
    play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled)
    family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to
    regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target
    genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity.
    Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a
    lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB.
    Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems
    to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP)
    pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to
    LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in
    positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory
    synapse organization, and dendrite formation and establishment of spines

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding ISS--
    GO:0005515protein binding IPI16446366
    GO:0008013beta-catenin binding IDA18936100
    GO:0051018protein kinase A binding IDA--
    GO:0070097delta-catenin binding ISS--
         
    Find genes that share ontologies with DACT1           About GenesLikeMe


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Dact1):
     cardiovascular system  digestive/alimentary  embryogenesis  growth/size/body  limbs/digits/tail 
     mortality/aging  nervous system  no phenotypic analysis  renal/urinary system  reproductive system 
     skeleton 

    Find genes that share phenotypes with DACT1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DACT1: Dact1tm1.3Bnrc Dact1tm1.1Bnrc Dact1tm1Yegc

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DACT1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DACT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DACT1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DACT1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DACT1:
    hsa-mir-124-3p (MIRT022775), hsa-mir-335-5p (MIRT018275)

    Block miRNA regulation of human, mouse, rat DACT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DACT1 (see all 50):
    hsa-miR-429 hsa-miR-25 hsa-miR-30d hsa-miR-29b-1* hsa-miR-30a hsa-miR-124 hsa-miR-649 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidDACT1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DACT1
    Predesigned siRNA for gene silencing in human, mouse, rat DACT1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DACT1

    Clone
    Products:
         
    OriGene clones in human, mouse for DACT1 (see all 13)
    OriGene ORF clones in mouse, rat for DACT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DACT1 (NM_016651)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DACT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DACT1

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DACT1
    Browse ESI BIO Cell Lines and PureStem Progenitors for DACT1 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACT1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    DACT1_HUMAN, Q9NYF0: Cytoplasm. Nucleus. Cell junction, synapse (By similarity). Note=Shuttles between the
    nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the
    cytoplasm in its presence
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    golgi apparatus1

    Gene Ontology (GO): Selected cellular component terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0005737cytoplasm IDA16446366
    GO:0030054cell junction IEA--
    GO:0030877colocalizes with beta-catenin destruction complex IDA--

    Find genes that share ontologies with DACT1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus


    Find genes that share SuperPaths with DACT1           About GenesLikeMe

    Pathways by sourceSee SuperPaths
    Show all pathways


    1 Reactome Pathway for DACT1
        degradation of DVL


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DACT1
    Interactions:

        GeneGlobe Interaction Network for DACT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 22)

    Selected Interacting proteins for DACT1 (Q9NYF01, 2, 3 ENSP000003374394) via UniProtKB, MINT, STRING, and/or I2D (see all 32)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253209 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253209 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253209 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253209 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253209 I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA18936100
    GO:0001702gastrulation with mouth forming second IEA--
    GO:0016055Wnt signaling pathway IEA--
    GO:0030177positive regulation of Wnt signaling pathway IDA--
    GO:0030178negative regulation of Wnt signaling pathway IMP18936100

    Find genes that share ontologies with DACT1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DACT1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for DACT1 gene (2 alternative transcripts): 
    NM_001079520.1  NM_016651.5  

    Unigene Cluster for DACT1:

    Dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
    Hs.48950  [show with all ESTs]
    Unigene Representative Sequence: NM_016651
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555845 ENST00000556859 ENST00000421793 ENST00000395153(uc010trv.2 uc001xdw.3 uc001xdx.3 uc010trw.2)
    ENST00000335867 ENST00000541264
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DACT1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DACT1 (see all 50):
    hsa-miR-429 hsa-miR-25 hsa-miR-30d hsa-miR-29b-1* hsa-miR-30a hsa-miR-124 hsa-miR-649 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidDACT1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DACT1
    Predesigned siRNA for gene silencing in human, mouse, rat DACT1
    Clone
    Products:
         
    OriGene clones in human, mouse for DACT1 (see all 13)
    OriGene ORF clones in mouse, rat for DACT1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DACT1 (NM_016651)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DACT1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DACT1
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DACT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DACT1
      QuantiTect SYBR Green Assays in human, mouse, rat DACT1
      QuantiFast Probe-based Assays in human, mouse, rat DACT1

    Additional mRNA sequence: 

    AF251079.2 AK299879.1 AK316164.1 AK316169.1 AK316237.1 AK316423.1 AY603415.1 BX161433.1 
    NR_046093.1 NR_046095.1 

    7 DOTS entries:

    DT.452996  DT.100733609  DT.100664518  DT.100758021  DT.102826367  DT.120784866  DT.100705246 

    Selected AceView cDNA sequences (see all 85):

    AI375466 AA953515 AU279699 BX112130 BU678380 AA236657 AA410372 BX441943 
    AA724806 BU742074 AA779757 BM677426 AI699673 BM722965 BX161433 AI216037 
    BM923155 BQ007981 CR610675 NM_016651 BK000256 AA977500 AI803159 BQ923996 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DACT1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
    SP1:        -                                       
    SP2:                                -               
    SP3:                                                


    ECgene alternative splicing isoforms for DACT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    DACT1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DACT1 Expression
    About this image


    DACT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Kidney (Urinary System)    fully expand to see all 2 entries
             Ureteric Bud Cells Ureteric Bud
             Metanephros
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Human embryonic stem cells (family)
     
     NULL (Uncategorized)
             CD2314-induced embryoid bodies
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced E15 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced E15 cells
    DACT1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DACT1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.48950
        Custom PCR Arrays for DACT1
    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DACT1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DACT1
    QuantiTect SYBR Green Assays in human, mouse, rat DACT1
    QuantiFast Probe-based Assays in human, mouse, rat DACT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for DACT1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dact11 , 5 dapper homolog 1, antagonist of beta-catenin (xenopus)1, 5 83.33(n)1
    83.05(a)1
      12 (29.39 cM)5
    590361  NM_001190466.11  NP_001177395.11 
     713098845 
    chicken
    (Gallus gallus)
    Aves DACT11 dapper, antagonist of beta-catenin, homolog 1 (Xenopus more 71.64(n)
    70.75(a)
      723789  NM_001044692.1  NP_001038157.1 
    lizard
    (Anolis carolinensis)
    Reptilia DACT16
    dishevelled-binding antagonist of beta-catenin 1
    64(a)
    1 ↔ 1
    GL343459.1(588604-615095)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76022 Xenopus laevis dapper 1 mRNA, complete cds 78.4(n)    AF488776.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dact11 dapper homolog 1, antagonist of beta-catenin (xenopus) 56.99(n)
    52.72(a)
      405799  NM_214731.2  NP_999896.2 


    ENSEMBL Gene Tree for DACT1 (if available)
    TreeFam Gene Tree for DACT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for DACT1 gene
    DACT22  

    Find genes that share paralogs with DACT1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for DACT1 (see all 394)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364624
    A colorectal cancer sample4--see VAR_0364622 S L mis40--------
    VAR_0364614
    A colorectal cancer sample4--see VAR_0364612 G C mis40--------
    VAR_0684294
    Neural tube defects (NTD)4--see VAR_0684292 N K mis40--------
    rs1922852761,2
    --40083549(+) ATAATG/TGCATT 1 -- us2k10--------
    rs1830372861,2
    --40083552(+) ATGGCA/GTTCTG 1 -- us2k10--------
    rs1870850831,2
    --40083773(+) TAATAA/GTCTAG 1 -- us2k10--------
    rs1405105101,2
    --40084094(+) TTTTTA/TAAAAA 1 -- us2k10--------
    rs1918909471,2
    --40084181(+) TGTGAC/TTTGAG 1 -- us2k10--------
    rs1842328881,2
    --40084182(+) GTGATC/TTGAGT 1 -- us2k10--------
    rs65732091,2
    C,F,A,H--40084225(+) TGTTTT/AAAAAT 1 -- us2k1 tfbs314Minor allele frequency- A:0.26NS EA NA WA CSA 784

    HapMap Linkage Disequilibrium report for DACT1 (59100685 - 59115039 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DACT1: --
    Human Gene Mutation Database (HGMD): DACT1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DACT1
    DNA2.0 Custom Variant and Variant Library Synthesis for DACT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 607861    OMIM disorders: --

    UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0
  • Neural tube defects (NTD) [MIM:182940]: Congenital malformations of the central nervous system and
    adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of
    neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly,
    myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of
    the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • 5 diseases for DACT1:    
    About MalaCards
    craniorachischisis    occipital encephalocele    spina bifida    neural tube defects
    hepatocellular carcinoma


    Find genes that share disorders with DACT1           About GenesLikeMe

    Genetic Association Database (GAD): DACT1
    Human Genome Epidemiology (HuGE) Navigator: DACT1 (2 documents)

    Export disorders for DACT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for DACT1 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with DACT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. (PubMed id 11970895)1, 2, 3 Cheyette B.N.R.... Moon R.T. (Dev. Cell 2002)
    2. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. (PubMed id 15580286)1, 2, 9 Yau T.O....Ng I.O. (Oncogene 2005)
    3. Identification of novel rare mutations of DACT1 in human neural tube defects. (PubMed id 22610794)1, 2 Shi Y.... Wang H.Y. (Hum. Mutat. 2012)
    4. Oncogenic function of DACT1 in colon cancer through the regulation of beta-catenin. (PubMed id 22470507)1, 2 Yuan G.... Fu W. (PLoS ONE 2012)
    5. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. (PubMed id 21718540)1, 2 Kivimae S.... Cheyette B.N. (BMC Biochem. 2011)
    6. Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation. (PubMed id 21262972)1, 2 Chen H....Chen Y.G. (J. Biol. Chem. 2011)
    7. Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort. (PubMed id 20844743)1, 4 FernA!ndez-Rozadilla C....Ruiz-Ponte C. (PLoS ONE 2010)
    8. Case-control study of six genes asymmetrically expressed in the two cerebral hemispheres: association of BAIAP2 with attention-deficit/hyperactivity disorder. (PubMed id 19733838)1, 4 RibasAcs M....Cormand B. (Biol. Psychiatry 2009)
    9. Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. (PubMed id 18936100)1, 2 Gao X.... Chen Y.G. (J. Biol. Chem. 2008)
    10. The evolutionally conserved activity of Dapper2 in antagonizing TGF- beta signaling. (PubMed id 17197390)1, 2 Su Y....Chen Y.-G. (FASEB J. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 51339 HGNC: 17748 AceView: DACT1 Ensembl:ENSG00000165617 euGenes: HUgn51339
    ECgene: DACT1 H-InvDB: DACT1

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for DACT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for DACT1 gene:
    Search GeneIP for patents involving DACT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     OriGene Antibodies for DACT1   OriGene RNAi products in human, mouse, rat for DACT1  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for DACT1  
     OriGene qSTAR qPCR primer pairs in human, mouse for DACT1   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for DACT1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DACT1   OriGene Custom Protein Services for DACT1  

     
     
     Block miRNA regulation of human, mouse, rat DACT1 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing DACT1
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DACT1 Predesigned siRNA for gene silencing in human, mouse, rat DACT1
     QuantiFast Probe-based Assays in human, mouse, rat DACT1 QuantiTect SYBR Green Assays in human, mouse, rat DACT1
     Custom PCR Arrays for DACT1 Search Chromatin IP Primers for DACT1
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DACT1  GeneGlobe Interaction Network for DACT1
     Regulatory tfbs in DACT1 promoter
     GenScript Custom Purified and Recombinant Proteins Services for DACT1 GenScript cDNA clones with any tag delivered in your preferred vector for DACT1
     GenScript Custom Assay Services for DACT1 GenScript Custom overexpressing Cell Line Services for DACT1
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for DACT1
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     DACT1 antibodies
     DACT1 proteins
     DACT1 lysates
     Antibodies for DACT1
     See all of Abcam's Antibodies, Kits and Proteins for DACT1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for DACT1
     Antibodies for DACT1
     ELISAs for DACT1
     CLIAs for DACT1



     Browse ESI BIO Cell Lines and PureStem Progenitors for DACT1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACT1
     SwitchGear 3'UTR luciferase reporter plasmids for DACT1
     SwitchGear Promoter luciferase reporter plasmids for DACT1
     ThermoFisher Antibodies for DACT1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DACT1
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DACT1
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DACT1
     LSBio Antibodies in human, mouse, rat for DACT1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for DACT1
      Search eBioscience for proteins for DACT1
      Search eBioscience for elisas for DACT1
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DACT1 gene at Home site.
    Version: 3.12.212 17 Sep 2014
    hostname: 356977-web1.xennexinc.com index build: 128 solr: 1.4