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DACT1 Gene(Protein Coding)

Dishevelled Binding Antagonist Of Beta Catenin 1

GCID:
GC14P058633
GIFtS:
50
Genes Participants
UDN Logo

Aliases for DACT1 Gene

Aliases for DACT1 Gene

  • Dishevelled Binding Antagonist Of Beta Catenin 1 2 3 5
  • Hepatocellular Carcinoma Novel Gene 3 Protein 3 4
  • Dapper Antagonist Of Catenin 1 3 4
  • HDPR1 3 4
  • DPR1 3 4
  • Dapper, Antagonist Of Beta-Catenin, Homolog 1 (Xenopus Laevis) 2
  • Dapper Homolog 1, Antagonist Of Beta-Catenin (Xenopus) 2
  • Dapper, Antagonist Of Beta-Catenin, Homolog 1 3
  • Heptacellular Carcinoma Novel Gene 3 3
  • Dapper Homolog 1 3
  • DAPPER1 3
  • DAPPER 3
  • THYEX3 3
  • FRODO 3
  • HNG3 4

External Ids for DACT1 Gene

Previous GeneCards Identifiers for DACT1 Gene

  • GC14P052900
  • GC14P057090
  • GC14P057094
  • GC14P058174
  • GC14P059100
  • GC14P039268

Summaries for DACT1 Gene

Entrez Gene Summary for DACT1 Gene

  • The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

GeneCards Summary for DACT1 Gene

DACT1 (Dishevelled Binding Antagonist Of Beta Catenin 1) is a Protein Coding gene. Diseases associated with DACT1 include Occipital Encephalocele and Craniorachischisis. Among its related pathways are Signaling by Wnt and CDK-mediated phosphorylation and removal of Cdc6. GO annotations related to this gene include beta-catenin binding and protein kinase A binding. An important paralog of this gene is DACT2.

UniProtKB/Swiss-Prot for DACT1 Gene

  • Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DACT1 Gene

Genomics for DACT1 Gene

Products:

  1. Regulatory Element

Regulatory Elements for DACT1 Gene

Enhancers for DACT1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G058532 1.8 Ensembl ENCODE 10.4 -99.7 -99656 2.7 ZNF316 FOXP2 EMSY ZBTB40 DACT1 PSMA3-AS1 HNRNPCP1 GC14P058521 RPL9P5
GH14G058746 1.1 Ensembl ENCODE 10.1 +113.1 113139 1.9 TBP NFIB RAD21 YY1 GATA4 ZSCAN5C RCOR1 FOS THAP11 DEK DACT1 LOC102723725 GC14P058645
GH14G058730 1 Ensembl ENCODE 10.8 +97.7 97659 2.5 CTCF JUN TAL1 SIN3A RAD21 CHAMP1 ZNF664 TCF12 GATA2 FOXK2 DACT1 LOC102723725 GC14P058645
GH14G058752 0.9 Ensembl ENCODE 10.1 +118.8 118835 1.6 STAT1 NFIA MAX RAD21 NR2F2 GABPA YY1 JUND ATF3 HNF4G DACT1 LOC102723725 GC14P058773
GH14G058571 0.8 Ensembl ENCODE 10.9 -61.9 -61862 1.4 ZNF341 BHLHE40 IKZF1 FOS IKZF2 DACT1 GC14P058566 GC14M058593
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DACT1 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the DACT1 gene promoter:

Genomic Location for DACT1 Gene

Chromosome:
14
Start:
58,633,967 bp from pter
End:
58,648,321 bp from pter
Size:
14,355 bases
Orientation:
Plus strand

Genomic View for DACT1 Gene

Genes around DACT1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DACT1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DACT1 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for DACT1 Gene

Proteins for DACT1 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for DACT1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NYF0-DACT1_HUMAN
    Recommended name:
    Dapper homolog 1
    Protein Accession:
    Q9NYF0
    Secondary Accessions:
    • A8MYJ2
    • Q86TY0

    Protein attributes for DACT1 Gene

    Size:
    836 amino acids
    Molecular mass:
    90174 Da
    Quaternary structure:
    • Can form homodimers and heterodimers with DACT2 or DACT3. Interacts with CSNK1D, PKA catalytic subunit, PKC-type kinase, CSNK2A1, CSNK2B, DVL1, DVL3, VANGL1, VANGL2, CTNND1 and HDAC1 (By similarity). Interacts with DVL2. Interacts with YWHAB; the interaction is enhanced by PKA phosphorylating DACT1 at Ser-237 and Ser-827. Interacts with CTNNB1 and HDAC1. Interacts with GSK3B; the interaction is indicative for an association of DACT1 with the beta-catenin destruction complex. Interacts with GSK3A.
    SequenceCaution:
    • Sequence=AAF65569.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAD61905.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for DACT1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DACT1 Gene

Protein Expression for DACT1 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Post-translational modifications for DACT1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DACT1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for DACT1 Gene

Domains & Families for DACT1 Gene

Protein Domains for DACT1 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for DACT1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NYF0

UniProtKB/Swiss-Prot:

DACT1_HUMAN :
  • The C-terminal PDZ-binding motif mediates interaction with the PDZ domains of DSH (Dishevelled) family proteins.
  • Belongs to the dapper family.
Domain:
  • The C-terminal PDZ-binding motif mediates interaction with the PDZ domains of DSH (Dishevelled) family proteins.
Family:
  • Belongs to the dapper family.
genes like me logo Genes that share domains with DACT1: view

No data available for Gene Families for DACT1 Gene

Function for DACT1 Gene

Products:

  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for DACT1 Gene

UniProtKB/Swiss-Prot Function:
Involved in regulation of intracellular signaling pathways during development. Specifically thought to play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled) family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity. Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB. Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP) pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory synapse organization, and dendrite formation and establishment of spines.

Gene Ontology (GO) - Molecular Function for DACT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001085 RNA polymerase II transcription factor binding IPI 18936100
GO:0005080 protein kinase C binding ISS,IBA --
GO:0005515 protein binding IPI 16446366
GO:0008013 beta-catenin binding IPI 18936100
GO:0042826 histone deacetylase binding IPI 18936100
genes like me logo Genes that share ontologies with DACT1: view
genes like me logo Genes that share phenotypes with DACT1: view

Human Phenotype Ontology for DACT1 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for DACT1 Gene

MGI Knock Outs for DACT1:

Animal Model Products

miRNA for DACT1 Gene

miRTarBase miRNAs that target DACT1

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for DACT1 Gene

Localization for DACT1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DACT1 Gene

Cytoplasm. Nucleus. Cell junction, synapse. Note=Shuttles between the nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the cytoplasm in its presence.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DACT1 gene
Compartment Confidence
nucleus 5
cytosol 5

Gene Ontology (GO) - Cellular Components for DACT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA 18936100
GO:0005654 nucleoplasm IDA --
GO:0005737 cytoplasm IDA,IEA 16446366
GO:0005829 cytosol TAS --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with DACT1: view

Pathways & Interactions for DACT1 Gene

genes like me logo Genes that share pathways with DACT1: view

Pathways by source for DACT1 Gene

SIGNOR curated interactions for DACT1 Gene

Inactivates:

Gene Ontology (GO) - Biological Process for DACT1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IDA 18936100
GO:0007275 multicellular organism development IEA --
GO:0007399 nervous system development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0021915 neural tube development IMP 22610794
genes like me logo Genes that share ontologies with DACT1: view

Drugs & Compounds for DACT1 Gene

Products:

  1. Drug
No Compound Related Data Available

Transcripts for DACT1 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for DACT1 Gene

(3) REFSEQ mRNAs :
(10) Additional mRNA sequences :
(85) Selected AceView cDNA sequences:
(6) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DACT1 Gene

Dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis):
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DACT1 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
SP1: -
SP2: -
SP3:

Relevant External Links for DACT1 Gene

GeneLoc Exon Structure for
DACT1
ECgene alternative splicing isoforms for
DACT1

Expression for DACT1 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DACT1 Gene

mRNA expression in normal human tissues for DACT1 Gene
mRNA expression by BioGPS for DACT1 GenemRNA expression by GTEx for DACT1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DACT1 Gene

This gene is overexpressed in Cerebrospinal fluid (23.1), Plasma (19.5), Blymphocyte (9.6), and Tlymphocyte (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for DACT1 Gene



NURSA nuclear receptor signaling pathways regulating expression of DACT1 Gene:

DACT1

SOURCE GeneReport for Unigene cluster for DACT1 Gene:

Hs.48950

Evidence on tissue expression from TISSUES for DACT1 Gene

  • Nervous system(2.2)

Phenotype-based relationships between genes and organs from Gene ORGANizer for DACT1 Gene

Germ Layers:
  • ectoderm
Systems:
  • integumentary
  • nervous
Organs:
Head and neck:
  • brain
  • head
General:
  • skin
  • spinal cord
genes like me logo Genes that share expression patterns with DACT1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for DACT1 Gene

Orthologs for DACT1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DACT1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia DACT1 34 35
  • 99.44 (n)
cow
(Bos Taurus)
 Mammalia DACT1 34 35
  • 84.31 (n)
dog
(Canis familiaris)
 Mammalia DACT1 34 35
  • 83.49 (n)
rat
(Rattus norvegicus)
 Mammalia Dact1 34
  • 83.37 (n)
mouse
(Mus musculus)
 Mammalia Dact1 34 16 35
  • 83.33 (n)
oppossum
(Monodelphis domestica)
 Mammalia DACT1 35
  • 76 (a)
 OneToOne
platypus
(Ornithorhynchus anatinus)
 Mammalia DACT1 35
  • 53 (a)
 OneToOne
chicken
(Gallus gallus)
 Aves DACT1 34 35
  • 71.64 (n)
lizard
(Anolis carolinensis)
 Reptilia DACT1 35
  • 64 (a)
 OneToOne
tropical clawed frog
(Silurana tropicalis)
 Amphibia dact1 34
  • 66.25 (n)
Str.3375 34
African clawed frog
(Xenopus laevis)
 Amphibia Xl.7602 34
zebrafish
(Danio rerio)
 Actinopterygii dact1 34 35
  • 56.99 (n)
Species where no ortholog for DACT1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DACT1 Gene

ENSEMBL:
Gene Tree for DACT1 (if available)
TreeFam:
Gene Tree for DACT1 (if available)

Paralogs for DACT1 Gene

Paralogs for DACT1 Gene

genes like me logo Genes that share paralogs with DACT1: view

Variants for DACT1 Gene

Sequence variations from dbSNP and Humsavar for DACT1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs778976254 Neural tube defects (NTD) [MIM:182940] 58,638,335(+) GCACC(C/T)GGGAG intron-variant, upstream-variant-2KB, reference, missense
VAR_036461 A colorectal cancer sample
VAR_036462 A colorectal cancer sample
VAR_068429 Neural tube defects (NTD) [MIM:182940]
rs754847137 Likely benign 58,646,633(+) CCTAA(A/C/G)CACAA nc-transcript-variant, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for DACT1 Gene

Variant ID Type Subtype PubMed ID
nsv1069798 CNV deletion 25765185
nsv1143752 CNV deletion 24896259

Variation tolerance for DACT1 Gene

Residual Variation Intolerance Score: 18.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.16; 87.87% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DACT1 Gene

Human Gene Mutation Database (HGMD)
DACT1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DACT1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DACT1 Gene

Disorders for DACT1 Gene

MalaCards: The human disease database

(7) MalaCards diseases for DACT1 Gene - From: Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
occipital encephalocele
craniorachischisis
neural tube defects
  • spina bifida
esophageal basaloid squamous cell carcinoma
  • basaloid squamous carcinoma of esophagus
myelomeningocele
  • meningomyelocele
- elite association - COSMIC cancer census association via MalaCards
Search DACT1 in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

DACT1_HUMAN
  • Neural tube defects (NTD) [MIM:182940]: Congenital malformations of the central nervous system and adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly, myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components. {ECO:0000269 PubMed:22610794}. Note=Disease susceptibility is associated with variations affecting the gene represented in this entry.

Relevant External Links for DACT1

Genetic Association Database (GAD)
DACT1
Human Genome Epidemiology (HuGE) Navigator
DACT1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DACT1
genes like me logo Genes that share disorders with DACT1: view

No data available for Genatlas for DACT1 Gene

Publications for DACT1 Gene

  1. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. (PMID: 15580286) Yau T.O. … Ng I.O. (Oncogene 2005) 3 4 22 64
  2. Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. (PMID: 11970895) Cheyette B.N.R. … Moon R.T. (Dev. Cell 2002) 2 3 4 64
  3. Oncogenic function of DACT1 in colon cancer through the regulation of beta-catenin. (PMID: 22470507) Yuan G. … Fu W. (PLoS ONE 2012) 3 4 64
  4. Identification of novel rare mutations of DACT1 in human neural tube defects. (PMID: 22610794) Shi Y. … Wang H.Y. (Hum. Mutat. 2012) 3 4 64
  5. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. (PMID: 21718540) Kivimae S. … Cheyette B.N. (BMC Biochem. 2011) 3 4 64

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