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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DACT1 Gene

protein-coding   GIFtS: 50
GCID: GC14P059100

Dishevelled-Binding Antagonist Of Beta-Catenin 1

(Previous names: dapper homolog 1, antagonist of beta-catenin (xenopus),...)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dishevelled-Binding Antagonist Of Beta-Catenin 11 2     DAPPER2
DPR12 3 5     HDPR12
Dapper Antagonist Of Catenin 12 3     THYEX32
Hepatocellular Carcinoma Novel Gene 3 Protein2 3     Dapper Homolog 12
DAPPER12 5     Dapper, Antagonist Of Beta-Catenin, Homolog 12
FRODO2 5     Heptacellular Carcinoma Novel Gene 32
Dapper Homolog 1, Antagonist Of Beta-Catenin (Xenopus)1     HNG33
Dapper, Antagonist Of Beta-Catenin, Homolog 1 (Xenopus Laevis)1     hDPR13

External Ids:    HGNC: 177481   Entrez Gene: 513392   Ensembl: ENSG000001656177   OMIM: 6078615   UniProtKB: Q9NYF03   

Export aliases for DACT1 gene to outside databases

Previous GC identifers: GC14P052900 GC14P057090 GC14P057094 GC14P058174 GC14P039268


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DACT1 Gene:
The protein encoded by this gene belongs to the dapper family, characterized by the presence of PDZ-binding motif
at the C-terminus. It interacts with, and positively regulates dishevelled-mediated signaling pathways during
development. Depletion of this mRNA from xenopus embryos resulted in loss of notochord and head structures, and
mice lacking this gene died shortly after birth from severe posterior malformations. Alternatively spliced
transcript variants have been found for this gene. (provided by RefSeq, Jan 2012)

GeneCards Summary for DACT1 Gene: 
DACT1 (dishevelled-binding antagonist of beta-catenin 1) is a protein-coding gene. Diseases associated with DACT1 include craniorachischisis, and occipital encephalocele. GO annotations related to this gene include protein kinase A binding and beta-catenin binding. An important paralog of this gene is DACT2.

UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0
Function: Involved in regulation of intracellular signaling pathways during development. Specifically thought to
play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled)
family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to
regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target
genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity.
Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a
lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB.
Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems
to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP)
pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to
LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in
positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory
synapse organization, and dendrite formation and establishment of spines




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.2  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DACT1 gene promoter:
         E2F-4   E2F-3a   E2F-5   AP-1   ATF-2   CUTL1   E2F-2   E2F   E2F-1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDACT1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DACT1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DACT1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q22.3

DACT1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DACT1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P059100:  view genomic region     (about GC identifiers)

Start:
59,100,685 bp from pter      End:
59,115,039 bp from pter
Size:
14,355 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0 (See protein sequence)
Recommended Name: Dapper homolog 1  
Size: 836 amino acids; 90174 Da
Subunit: Can form homodimers and heterodimers with DACT2 or DACT3. Interacts with CSNK1D, PKA catalytic subunit,
PKC-type kinase, CSNK2A1, CSNK2B, DVL1, DVL3, VANGL1, VANGL2, CTNND1 and HDAC1 (By similarity). Interacts with
DVL2. Interacts with YWHAB; the interaction is enhanced by PKA phosphorylating DACT1 at Ser-237 and Ser-827.
Interacts with CTNNB1 and HDAC1. Interacts with GSK3B; the interaction is indicative for an association of DACT1
with the beta-catenin destruction complex. Interacts with GSK3A
Subcellular location: Cytoplasm. Nucleus. Cell junction, synapse (By similarity). Note=Shuttles between the
nucleus and the cytoplasm. Seems to be nuclear in the absence of Wnt signaling and to translocate to the
cytoplasm in its presence
Sequence caution: Sequence=AAF65569.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=CAD61905.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A8MYJ2 Q86TY0
Alternative splicing: 2 isoforms:  Q9NYF0-1   Q9NYF0-2   

Explore the universe of human proteins at neXtProt for DACT1: NX_Q9NYF0

Explore proteomics data for DACT1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9NYF0

  • DACT1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DACT1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001072988.1  NP_057735.2  

    ENSEMBL proteins: 
     ENSP00000451598   ENSP00000404297   ENSP00000378581   ENSP00000378582   ENSP00000337439  
     ENSP00000442850  

    Human Recombinant Protein Products for DACT1: 
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    Novus Biologicals DACT1 Protein
    Novus Biologicals DACT1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DACT1 

    Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm IDA16446366
    GO:0030054cell junction IEA--
    GO:0030877colocalizes with beta-catenin destruction complex IDA--
    GO:0045202synapse IEA--

    DACT1 for ontologies           About GeneDecksing



    DACT1 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for DACT1 

    Assay Products for DACT1: 
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    Cloud-Clone Corp. CLIAs for DACT1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR024843 Dapper
     IPR024848 Dact1

    Graphical View of Domain Structure for InterPro Entry Q9NYF0

    ProtoNet protein and cluster: Q9NYF0

    UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0
    Domain: The C-terminal PDZ-binding motif mediates interaction with the PDZ domains of DSH (Dishevelled) family
    proteins (By similarity)
    Similarity: Belongs to the dapper family


    DACT1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DACT1_HUMAN, Q9NYF0
    Function: Involved in regulation of intracellular signaling pathways during development. Specifically thought to
    play a role in canonical and/or non-canonical Wnt signaling pathways through interaction with DSH (Dishevelled)
    family proteins. The activation/inhibition of Wnt signaling may depend on the phosphorylation status. Proposed to
    regulate the degradation of CTNNB1/beta-catenin, thereby modulating the transcriptional activation of target
    genes of the Wnt signaling pathway. Its function in stabilizing CTNNB1 may involve inhibition of GSK3B activity.
    Promotes the membrane localization of CTNNB1. The cytoplasmic form can induce DVL2 degradation via a
    lysosome-dependent mechanism; the function is inhibited by PKA-induced binding to 14-3-3 proteins, such as YWHAB.
    Seems to be involved in morphogenesis at the primitive streak by regulating VANGL2 and DVL2; the function seems
    to be independent of canonical Wnt signaling and rather involves the non-canonical Wnt/planar cell polarity (PCP)
    pathway (By similarity). The nuclear form may prevent the formation of LEF1:CTNNB1 complex and recruit HDAC1 to
    LEF1 at target gene promoters to repress transcription thus antagonizing Wnt signaling. May be involved in
    positive regulation of fat cell differentiation. During neuronal differentiation may be involved in excitatory
    synapse organization, and dendrite formation and establishment of spines

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005080protein kinase C binding ISS--
    GO:0005515protein binding IPI16446366
    GO:0008013beta-catenin binding IDA18936100
    GO:0051018protein kinase A binding IDA--
    GO:0070097delta-catenin binding ISS--
         
    DACT1 for ontologies           About GeneDecksing


    Phenotypes:
         11 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Dact1):
     cardiovascular system  digestive/alimentary  embryogenesis  growth/size  limbs/digits/tail 
     mortality/aging  nervous system  no phenotypic analysis  renal/urinary system  reproductive system 
     skeleton 

    DACT1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DACT1: Dact1tm1.3Bnrc Dact1tm1.1Bnrc Dact1tm1Yegc

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DACT1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DACT1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DACT1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DACT1 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DACT1
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    hsa-miR-429 hsa-miR-25 hsa-miR-30d hsa-miR-29b-1* hsa-miR-30a hsa-miR-124 hsa-miR-649 hsa-miR-4325
    SwitchGear 3'UTR luciferase reporter plasmidDACT1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACT1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DACT1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 21)

    5/31 Interacting proteins for DACT1 (Q9NYF01, 2, 3 ENSP000003374394) via UniProtKB, MINT, STRING, and/or I2D (see all 31)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CSNK2BP678702, 3MINT-8253209 I2D: score=2 
    ENSG00000206406P678702, 3MINT-8253209 I2D: score=2 
    ENSG00000224398P678702, 3MINT-8253209 I2D: score=2 
    ENSG00000224774P678702, 3MINT-8253209 I2D: score=2 
    ENSG00000228875P678702, 3MINT-8253209 I2D: score=2 
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IDA18936100
    GO:0001702gastrulation with mouth forming second IEA--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0030177positive regulation of Wnt receptor signaling pathway IDA--
    GO:0030178negative regulation of Wnt receptor signaling pathway IMP18936100

    DACT1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DACT1

    Search CenterWatch for drugs/clinical trials and news about DACT1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DACT1 gene (2 alternative transcripts): 
    NM_001079520.1  NM_016651.5  

    Unigene Cluster for DACT1:

    Dapper, antagonist of beta-catenin, homolog 1 (Xenopus laevis)
    Hs.48950  [show with all ESTs]
    Unigene Representative Sequence: NM_016651
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000555845 ENST00000556859 ENST00000421793 ENST00000395151 ENST00000395153(uc010trv.2 uc001xdw.3 uc001xdx.3 uc010trw.2)
    ENST00000335867 ENST00000541264
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidDACT1 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DACT1
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DACT1

    Additional mRNA sequence: 

    AF251079.2 AK299879.1 AK316164.1 AK316169.1 AK316237.1 AK316423.1 AY603415.1 BX161433.1 
    NR_046093.1 NR_046095.1 

    7 DOTS entries:

    DT.452996  DT.100733609  DT.100664518  DT.100758021  DT.102826367  DT.120784866  DT.100705246 

    24/85 AceView cDNA sequences (see all 85):

    BU678380 AI375466 BX112130 NM_016651 AA236657 BK000256 AA953515 AA977500 
    BQ007981 CR610675 BM677426 AA724806 AI699673 BM722965 BU742074 AA779757 
    AA410372 AI216037 BX441943 BX161433 AU279699 BM923155 AA938880 AA625232 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DACT1    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c
    SP1:        -                                       
    SP2:                                -               
    SP3:                                                


    ECgene alternative splicing isoforms for DACT1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DACT1 expression in normal human tissues (normalized intensities)      DACT1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    DACT1 Expression
    About this image


    DACT1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/18 selected tissues (see all 18) fully expand
     
     Mesoderm (Gastrulation Derivatives)    fully expand to see all 4 entries
             Mesoderm Cells Mesoderm
             Mesoderm
             mesenchyme   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 2 entries
             Ureter
             visceral organ/urogenital sinus   
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             HyStem+TGFbeta3+GDF5-induced E15 cells
             Normal Human osteoblasts (NHOST)   
     
     Uncategorized (Uncategorized)    fully expand to see all 2 entries
             PureStem Progenitor ES-101
     
     Ectoderm (Gastrulation Derivatives)
             PureStem ES-210, Ecto-ntu Progenitor

    See DACT1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DACT1

    SOURCE GeneReport for Unigene cluster: Hs.48950
        SABiosciences Custom PCR Arrays for DACT1
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DACT1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACT1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for DACT1 gene from 5/12 species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dact11 , 5 dapper homolog 1, antagonist of beta-catenin (xenopus)1, 5 83.33(n)1
    83.05(a)1
      12 (29.39 cM)5
    590361  NM_001190466.11  NP_001177395.11 
     713098845 
    chicken
    (Gallus gallus)
    Aves DACT11 dapper, antagonist of beta-catenin, homolog 1 (Xenopus more 72.19(n)
    71.87(a)
      723789  NM_001044692.1  NP_001038157.1 
    lizard
    (Anolis carolinensis)
    Reptilia DACT16
    Uncharacterized protein
    64(a)
    1 ↔ 1
    GL343459.1(588604-615095)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.76022 Xenopus laevis dapper 1 mRNA, complete cds 78.4(n)    AF488776.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dact11 dapper homolog 1, antagonist of beta-catenin (xenopus) 56.86(n)
    52.69(a)
      405799  NM_214731.2  NP_999896.2 


    ENSEMBL Gene Tree for DACT1 (if available)
    TreeFam Gene Tree for DACT1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DACT1 gene
    DACT22  

    DACT1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/394 SNPs in DACT1 are shown (see all 394)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0364624
    A colorectal cancer sample4--see VAR_0364622 S L mis40--------
    VAR_0364614
    A colorectal cancer sample4--see VAR_0364612 G C mis40--------
    VAR_0684294
    Neural tube defects (NTD)4--see VAR_0684292 N K mis40--------
    VAR_0684304
    ----see VAR_0684302 V G mis40--------
    VAR_0684324
    ----see VAR_0684322 T K mis40--------
    VAR_0684274
    ----see VAR_0684272 R W mis40--------
    VAR_0684314
    ----see VAR_0684312 D G mis40--------
    VAR_0684284
    ----see VAR_0684282 D G mis40--------
    rs1922852761,2
    --40083549(+) ATAATG/TGCATT 1 -- us2k10--------
    rs1830372861,2
    --40083552(+) ATGGCA/GTTCTG 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DACT1 (59100685 - 59115039 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for DACT1: --

    Human Gene Mutation Database (HGMD): DACT1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DACT1
    DNA2.0 Custom Variant and Variant Library Synthesis for DACT1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607861    OMIM disorders: --

    UniProtKB/Swiss-Prot: DACT1_HUMAN, Q9NYF0
  • Neural tube defects (NTD) [MIM:182940]: Congenital malformations of the central nervous system and
    adjacent structures related to defective neural tube closure during the first trimester of pregnancy. Failure of
    neural tube closure can occur at any level of the embryonic axis. Common NTD forms include anencephaly,
    myelomeningocele and spina bifida, which result from the failure of fusion in the cranial and spinal region of
    the neural tube. NTDs have a multifactorial etiology encompassing both genetic and environmental components.
    Note=Disease susceptibility is associated with variations affecting the gene represented in this entry

  • 12 diseases for DACT1:    About MalaCards
    craniorachischisis    occipital encephalocele    neural tube defects    renal agenesis
    hepatocellular carcinoma    spina bifida    cerebritis    colorectal cancer
    lung cancer    esophagitis    colon cancer    neuronitis


    DACT1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DACT1
    Human Genome Epidemiology (HuGE) Navigator: DACT1 (2 documents)

    Export disorders for DACT1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DACT1 gene, integrated from 9 sources (see all 27):
    (articles sorted by number of sources associating them with DACT1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Dapper, a Dishevelled-associated antagonist of beta-catenin and JNK signaling, is required for notochord formation. (PubMed id 11970895)1, 2, 3 Cheyette B.N.R.... Moon R.T. (2002)
    2. HDPR1, a novel inhibitor of the WNT/beta-catenin signaling, is frequently downregulated in hepatocellular carcinoma: involvement of methylation-mediated gene silencing. (PubMed id 15580286)1, 2, 9 Yau T.O....Ng I.O. (2005)
    3. Identification of novel rare mutations of DACT1 in human neural tube defects. (PubMed id 22610794)1, 2 Shi Y.... Wang H.Y. (2012)
    4. Oncogenic function of DACT1 in colon cancer through th e regulation of b-catenin. (PubMed id 22470507)1, 2 Yuan G....Fu W. (2012)
    5. All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases. (PubMed id 21718540)1, 2 Kivimae S....Cheyette B.N. (2011)
    6. Protein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradation. (PubMed id 21262972)1, 2 Chen H....Chen Y.G. (2011)
    7. Single nucleotide polymorphisms in the Wnt and BMP pa thways and colorectal cancer risk in a Spanish cohort. (PubMed id 20844743)1, 4 FernA!ndez-Rozadilla C....Ruiz-Ponte C. (2010)
    8. Case-control study of six genes asymmetrically expres sed in the two cerebral hemispheres: association of BAIAP2 with attention-defic it/hyperactivity disorder. (PubMed id 19733838)1, 4 RibasAcs M....Cormand B. (2009)
    9. Dapper1 is a nucleocytoplasmic shuttling protein that negatively modulates Wnt signaling in the nucleus. (PubMed id 18936100)1, 2 Gao X....Chen Y.G. (2008)
    10. The evolutionally conserved activity of Dapper2 in ant agonizing TGF-beta signaling. (PubMed id 17197390)1, 2 Su Y....Chen Y.G. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 51339 HGNC: 17748 AceView: DACT1 Ensembl:ENSG00000165617 euGenes: HUgn51339
    ECgene: DACT1 H-InvDB: DACT1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DACT1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DACT1 gene:
    Search GeneIP for patents involving DACT1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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