Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DACH2 Gene

Aliases for DACH2 Gene

  • Dachshund Family Transcription Factor 2 2 3
  • Dachshund Homolog 2 (Drosophila) 2
  • Dach2 4

External Ids for DACH2 Gene

Previous GeneCards Identifiers for DACH2 Gene

  • GC0XP080783
  • GC0XP082480
  • GC0XP083439
  • GC0XP084175
  • GC0XP085209
  • GC0XP085290
  • GC0XP085403
  • GC0XP078980

Summaries for DACH2 Gene

Entrez Gene Summary for DACH2 Gene

  • This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]

GeneCards Summary for DACH2 Gene

DACH2 (Dachshund Family Transcription Factor 2) is a Protein Coding gene. Diseases associated with DACH2 include allan-herndon-dudley syndrome. GO annotations related to this gene include nucleotide binding.

UniProtKB/Swiss-Prot for DACH2 Gene

  • Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each others expression (By similarity). Probably binds to DNA via its DACHbox-N domain.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DACH2 Gene

Genomics for DACH2 Gene

Regulatory Elements for DACH2 Gene

Genomic Location for DACH2 Gene

Start:
86,148,451 bp from pter
End:
86,832,604 bp from pter
Size:
684,154 bases
Orientation:
Plus strand

Genomic View for DACH2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DACH2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DACH2 Gene

Proteins for DACH2 Gene

  • Protein details for DACH2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96NX9-DACH2_HUMAN
    Recommended name:
    Dachshund homolog 2
    Protein Accession:
    Q96NX9
    Secondary Accessions:
    • B1AJV3
    • B4DQG3
    • Q8NAY3
    • Q8ND17
    • Q96N55

    Protein attributes for DACH2 Gene

    Size:
    599 amino acids
    Molecular mass:
    65323 Da
    Quaternary structure:
    • Interacts with SIX6 and EYA2.

    Alternative splice isoforms for DACH2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DACH2 Gene

Proteomics data for DACH2 Gene at MOPED

Post-translational modifications for DACH2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DACH2 Gene

Domains for DACH2 Gene

Protein Domains for DACH2 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q96NX9

UniProtKB/Swiss-Prot:

DACH2_HUMAN :
  • Q96NX9
Domain:
  • The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain.
Family:
  • Belongs to the DACH/dachshund family.
genes like me logo Genes that share domains with DACH2: view

No data available for Gene Families for DACH2 Gene

Function for DACH2 Gene

Molecular function for DACH2 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each others expression (By similarity). Probably binds to DNA via its DACHbox-N domain.

Gene Ontology (GO) - Molecular Function for DACH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with DACH2: view

Phenotypes for DACH2 Gene

MGI mutant phenotypes for DACH2:
inferred from 2 alleles
GenomeRNAi human phenotypes for DACH2:
genes like me logo Genes that share phenotypes with DACH2: view

Animal Models for DACH2 Gene

MGI Knock Outs for DACH2:

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for DACH2 Gene

Localization for DACH2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DACH2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DACH2 Gene COMPARTMENTS Subcellular localization image for DACH2 gene
Compartment Confidence
nucleus 4
cytosol 2
endoplasmic reticulum 1
extracellular 1
lysosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DACH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
genes like me logo Genes that share ontologies with DACH2: view

Pathways for DACH2 Gene

SuperPathways for DACH2 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DACH2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0006355 regulation of transcription, DNA-templated IEA --
GO:0046545 development of primary female sexual characteristics IEA --
genes like me logo Genes that share ontologies with DACH2: view

No data available for Pathways by source for DACH2 Gene

Transcripts for DACH2 Gene

Unigene Clusters for DACH2 Gene

Dachshund homolog 2 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DACH2 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1: - -
SP2: - -
SP3: -

Relevant External Links for DACH2 Gene

GeneLoc Exon Structure for
DACH2
ECgene alternative splicing isoforms for
DACH2

Expression for DACH2 Gene

mRNA expression in normal human tissues for DACH2 Gene

mRNA differential expression in normal tissues according to GTEx for DACH2 Gene

This gene is overexpressed in Brain - Nucleus accumbens (basal ganglia) (6.9), Brain - Anterior cingulate cortex (BA24) (6.1), Brain - Frontal Cortex (BA9) (5.5), Brain - Hypothalamus (5.1), Brain - Hippocampus (4.7), Brain - Amygdala (4.6), Brain - Putamen (basal ganglia) (4.4), Brain - Caudate (basal ganglia) (4.2), and Brain - Cortex (4.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for DACH2 Gene

SOURCE GeneReport for Unigene cluster for DACH2 Gene Hs.86603

genes like me logo Genes that share expressions with DACH2: view

No data available for mRNA Expression by UniProt/SwissProt for DACH2 Gene

Orthologs for DACH2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DACH2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DACH2 35
  • 99.45 (n)
  • 98.9 (a)
DACH2 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DACH2 36
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DACH2 35
  • 91.15 (n)
  • 91.1 (a)
DACH2 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Dach2 35
  • 90.37 (n)
  • 93.32 (a)
Dach2 16
Dach2 36
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 63 (a)
OneToMany
-- 36
  • 75 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia DACH2 36
  • 74 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Dach2 35
  • 89.51 (n)
  • 91.2 (a)
chicken
(Gallus gallus)
Aves DACH2 35
  • 77.78 (n)
  • 80 (a)
DACH2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DACH2 36
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia dach2 35
  • 73.31 (n)
  • 76.84 (a)
zebrafish
(Danio rerio)
Actinopterygii dacha 35
  • 68.96 (n)
  • 72.61 (a)
dacha 36
  • 66 (a)
OneToMany
dachb 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta dac 36
  • 15 (a)
OneToMany
dac 37
  • 70 (a)
worm
(Caenorhabditis elegans)
Secernentea dac-1 36
  • 28 (a)
OneToMany
Species with no ortholog for DACH2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DACH2 Gene

ENSEMBL:
Gene Tree for DACH2 (if available)
TreeFam:
Gene Tree for DACH2 (if available)

Paralogs for DACH2 Gene

Selected SIMAP similar genes for DACH2 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with DACH2: view

No data available for Paralogs for DACH2 Gene

Variants for DACH2 Gene

Sequence variations from dbSNP and Humsavar for DACH2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type MAF
rs173363 -- 86,163,318(+) gcctg(G/T)attat intron-variant
rs181560 -- 86,147,287(-) GCACA(A/G)TCTCG upstream-variant-2KB
rs195032 -- 86,274,465(-) AAAAA(A/G)AAAAA intron-variant
rs195033 -- 86,274,342(+) CCACT(C/G)AGGCT intron-variant
rs195034 -- 86,273,757(+) TGATA(C/T)TAGTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DACH2 Gene

Variant ID Type Subtype PubMed ID
esv2740276 CNV Deletion 23290073
esv2227206 CNV Deletion 18987734
esv2740278 CNV Deletion 23290073
nsv510845 CNV Loss 20534489
nsv6985 CNV Loss 18451855
nsv515217 CNV Loss 21397061
esv2538515 CNV Deletion 19546169
nsv436631 CNV Deletion 17901297
esv2740279 CNV Deletion 23290073
nsv512686 CNV Loss 21212237
esv2659577 CNV Deletion 23128226
nsv499477 CNV Loss 21111241
nsv525697 CNV Gain 19592680
esv26654 CNV Loss 19812545
nsv6986 CNV Insertion 18451855
esv2164340 CNV Deletion 18987734
nsv425495 CNV Loss 16902084
esv268528 CNV Insertion 20981092
esv274047 CNV Insertion 20981092
nsv525946 CNV Gain 19592680
esv2740280 CNV Deletion 23290073
nsv520837 CNV Gain 19592680
nsv526936 CNV Gain 19592680
nsv519525 CNV Gain 19592680

Relevant External Links for DACH2 Gene

HapMap Linkage Disequilibrium report
DACH2
Human Gene Mutation Database (HGMD)
DACH2
Locus Specific Mutation Databases (LSDB)
DACH2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DACH2 Gene

Disorders for DACH2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for DACH2 Gene including...

Search for DACH2 Gene in MalaCards »

(2) University of Copenhagen DISEASES for DACH2 Gene

Relevant External Links for DACH2

Genetic Association Database (GAD)
DACH2
Human Genome Epidemiology (HuGE) Navigator
DACH2
genes like me logo Genes that share disorders with DACH2: view

No data available for UniProtKB/Swiss-Prot for DACH2 Gene

Publications for DACH2 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B. (PMID: 15459172) Bione S. … Toniolo D. (Hum. Reprod. 2004) 3 48
  3. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  4. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 48
  5. The DNA sequence of the human X chromosome. (PMID: 15772651) Ross M.T. … Bentley D.R. (Nature 2005) 4

Products for DACH2 Gene

Sources for DACH2 Gene

Back to Top

Content