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Aliases & Descriptions for DACH2
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc
, and/or 7 Ensembl ,
8 miRBase )About This Section
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Aliases Dach2 3 FLJ31391 2 MGC138545 2
Descriptions dachshund 2 2 dachshund homolog 2 (Drosophila) 2
Search outside databases for aliases for DACH2 genePrevious GC identifers: GC0XP080783 GC0XP082480 GC0XP083439 GC0XP084175
Summaries for DACH2 (According to Entrez Gene ,
Wikipedia's
Gene Wiki ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
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EntrezGene summary for DACH2 : This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, atranscription factor involved in cell fate determination in the eye, limb and genital disc of thefly. The encoded protein contains two characteristic dachshund domains: an N-terminal domainresponsible for DNA binding and a C-terminal domain responsible for protein-protein interactions.This gene is located on the X chromosome and is subject to inactivation by DNA methylation. Theencoded protein may be involved in regulation of organogenesis and myogenesis, and may play a rolein premature ovarian failure. Multiple transcript variants encoding different isoforms have beenfound for this gene. [provided by RefSeq] UniProtKB/Swiss-Prot: DACH2_HUMAN, Q96NX9 Function : Transcription factor that is involved in regulation of organogenesis. Seems to be aregulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation bydirectly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Isrecruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also toinvolve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 inregulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated bythe overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (Bysimilarity). Probably binds to DNA via its DACHbox-N domain
Genomic Location for DACH2
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 36) ,
and/or miRBase ,
Genomic Views according to
UCSC and
Ensembl ,
Transcription factor binding sites according to
SABiosciences )About This Section
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Genomic View : UCSC Golden Path with GeneCards custom track Transcription factor binding sites upstream to the DACH2 gene Entrez Gene cytogenetic band: Xq21.3 Ensembl cytogenetic band: Xq21.2 HGNC cytogenetic band: Xq21.3 DACH2 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc gene densities for chromosome X GeneLoc Exon Structure
GeneLoc location for GC0XP085209:
(about GC identifiers )
Start:
85,290,118 bp from pter
End:
85,974,261 bp from pter
Size:
684,144 bases
Orientation:
plus strand
RefSeq DNA sequence: NC_000023.9 NT_011651.16 Proteins for DACH2
(According to
1 UniProtKB ,
and/or Ensembl ,
Phosphorylation sites according to 2 Phosphosite ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Enzo Life Sciences ,
Abnova ,
OriGene and/or,
Abcam ,
Biochemical Assays by
Invitrogen ,
Millipore ,
R&D Systems ,
Cell Signaling Technology , and/or
Enzo Life Sciences ,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene ,
Antibodies by Invitrogen ,
Millipore ,
Sigma-Aldrich ,
R&D Systems ,
Cell Signaling Technology ,
Abcam ,
Abnova , and/or
Novus Biologicals )
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UniProtKB/Swiss-Prot: DACH2_HUMAN, Q96NX9 (See
protein sequence )Recommended Name: Dachshund homolog 2 Size : 599 amino acids; 65323 Da
Subunit : Interacts with SIX6 and EYA2 (By similarity)
Subcellular location : Nucleus (Probable)
Secondary accessions : Q8NAY3 Q8ND17 Q96N55Alternative splicing : 3 isoforms : Q96NX9-1 Q96NX9-2 Q96NX9-3
REFSEQ proteins (3 alternative transcripts):
NP_001132986.1 NP_001132987.1 NP_444511.1 ENSEMBL proteins: ENSP00000362223 ENSP00000345134 ENSP00000362217 Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 1 Gene Ontology (GO) cellular component term (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0005634 nucleus
IEA --
About this table Antibodies for DACH2: Assays for DACH2:
Protein
Domains/ Families for DACH2(According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
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Graphical View of Domain Structure for InterPro Entry Q96NX9 ProtoNet protein and cluster: Q96NX9
UniProtKB/Swiss-Prot: DACH2_HUMAN, Q96NX9 Domain : The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to thatof the forkhead/winged helix domain (By similarity) Similarity : Belongs to the DACH/dachshund family
Gene Function for DACH2
(According to MGI Jun 06 2009, UniProtKB ,
IUBMB ,and/or Genatlas ,
shRNA from
OriGene ,
Sigma-Aldrich , RNAi from
Sigma-Aldrich ,
RNAi Products ,
Clones , and
Q-PCR Products
from Invitrogen ,
Millipore ,
OriGene , and/or
Abnova ,
siRNAs from
Applied Biosystems ,
SYBR primers from OriGene ,
Cell-based Assays from Millipore ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001139514 Applied Biosystems Silencer ® siRNAs for DACH2 Sigma-Aldrich siRNA for DACH2 Sigma-Aldrich shRNA for DACH2 Explore Sigma-Aldrich super-pooled esiRNAs                OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001139514                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001139514                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001139514  Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_053281 UniProtKB/Swiss-Prot: DACH2_HUMAN, Q96NX9 Function : Transcription factor that is involved in regulation of organogenesis. Seems to be aregulator for SIX1 and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation bydirectly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Isrecruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6 corepression seems also toinvolve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 inregulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated bythe overlying ectoderm, and DACH2 and PAX3 positively regulate each other's expression (Bysimilarity). Probably binds to DNA via its DACHbox-N domain
1 MGI mutant phenotype (inferred from 2 alleles ) (MGI details for Dach2) :3 Gene Ontology (GO) molecular function terms (links to tree view) :
About this table
Pathways & Interactions for DACH2
(Pathways according to Invitrogen
(maps by GeneGo ),
Millipore ,
Cell Signaling Technology ,
Sigma-Aldrich ,
KEGG
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Proteins Network according to
SABiosciences ,
Interactions according to 1 UniProtKB ,
2 MINT , and/or
3 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene .)
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2 Interacting proteins for DACH2 (ENSP00000362217 3 ) via UniProtKB, MINT, and/or STRING About this table 3 Gene Ontology (GO) biological process terms (links to tree view) :
GO ID Qualified GO term Evidence PubMed IDs GO:0006350 transcription
IEA -- GO:0006355 regulation of transcription, DNA-dependent
IEA -- GO:0007275 multicellular organismal development
IEA --
About this table
Drugs & Compounds for DACH2 (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
Sigma-Aldrich , Tocris Bioscience , and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB )
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Browse Tocris compounds for DACH2
Transcripts for DACH2(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
non coding RNAs according to
RNAdb ,
ESTs according to GeneTide ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from Invitrogen ,
Millipore , and/or
Abnova ,
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shRNA from
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OriGene ,
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               OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3 ): NM_001139514 Sigma-Aldrich siRNA for DACH2 Sigma-Aldrich shRNA for DACH2 Explore Sigma-Aldrich super-pooled esiRNAs
Applied Biosystems Silencer ® siRNAs: NM_001139514 NM_001139515 NM_053281
REFSEQ mRNAs for DACH2 gene (3 alternative transcripts): NM_001139514.1 NM_001139515.1 NM_053281.3
Applied Biosystems TaqMan ® Gene Expression Assays: NM_001139514 NM_001139515 NM_053281
               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3 ): NM_001139514                                  Myc/DDK tagged cDNA clones in CMV expression vector (see all 3 ): NM_001139514                                  untagged cDNA clones in CMV expression vector (see all 4 ): NM_001139514  
Additional cDNA sequence: AF428101.1 AK055953.1 AK091842.1 AK290596.1 AK294498.1 AK295648.1 AK298787.1 AL834456.1 BC040213.1 BC048423.1 BC114950.1
6 DOTS entries : DT.40117719 DT.100019168 DT.406928 DT.101973322 DT.100749541 DT.121302091
24/26 AceView cDNA sequences (see all 26
):AL712187 NM_053281 AK091842 BX107126 AL834456 AA776596 AF428101 AX747214 AA214293 BQ267186 BX471230 AW780006 BQ777596 CK906044 BQ272444 AL699905 AK055953 BQ777896 BC048423 AI809398 BC040213 BG704485 AA330188 BU950092
highest scoring ESTs for DACH2 :AI809398 AA214293 AA776596 AA884555 AF428101 AK055953 AK091842 AL834456 AW780006 BQ272444
Unigene Cluster for DACH2: Dachshund homolog 2 (Drosophila) Hs.86603 [show with all ESTs ] Unigene Representative Sequence: BC048423 GeneLoc Exon Structure 3 Alternative Splicing Database (ASD) splice patterns (SP) for DACH2 ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b SP1 :   -   -                           SP2 :     -                     -       SP3 :                         -      
About this scheme ECgene alternative splicing isoforms for DACH2 3 Ensembl transcripts including schematic representations : ENST00000373131
ENST00000344497
ENST00000373125
Expression for DACH2
(Experimental results according to
1 GeneNote
and GNF BioGPS ,
probe sets-to-genes annotations according to
2 GeneAnnot ,
3 GeneTide ,
Sets of similar genes according to GeneDecks ,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP ,
plus additional links to
SOURCE , and/or
GNF
BioGPS , and/or
EXPOLDB , and/or
UniProtKB ,
Expression Assays from
Applied Biosystems
)
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DACH2 expression in normal and diseased human tissues Applied Biosystems TaqMan ® Gene Expression Assays for DACH2 1 / 2 / 3
3 probe-sets matching DACH2 gene Data from
(Publications) and GNF BioGPS About these images About these images CGAP SAGE TAG: GCTGCTGCAGSOURCE GeneReport for Unigene cluster: Hs.86603
Orthologs for DACH2
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
and/or
5 MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase ,
Gene Trees according to Ensembl )
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Orthologs for DACH2 gene from 5/6 species (see all 6
)
About this table Species with no ortholog for DACH2 ENSEMBL Gene Tree for DACH2 Paralogs for DACH2 (Paralogs according to 1 HomoloGene and 2 Ensembl , Pseudogenes according to 3 Pseudogene.org )About This Section
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Paralogs for DACH2 gene DACH1 2
SNPs/Variants for DACH2 (According to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE , and
UniProtKB ,
Linkage Disequilibrium by HapMap ,
Genotyping Reagents from
Applied Biosystems )
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HapMap Linkage Disequilibrium images for DACH2 (up to first 250kb)
Disorders & Mutations for DACH2
(in which this Gene is Involved, According to
OMIM, UniProtKB ,
PharmGKB ,
Genatlas , GeneTests ,
Blood group antigen gene mutations by BGMUT ,
HGMD, GAD ,
HuGE Navigator ,
BCGD ,
and/or TGDB .)
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OMIM: 300608 Genetic Association Database: DACH2 Human Genome Epidemiology Navigator: DACH2 (1 document)
Medical News for DACH2 (Possibly Related Articles in
Doctor's Guide )
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--
Publications for DACH2 (in
PubMed .
Associations of this gene to articles via
1 Novoseek ,
2 HGNC ,
3 Entrez Gene ,
4 UniProtKB/Swiss-Prot ,
5 UniProtKB/TrEMBL ,
6 GAD , and/or
7 PharmGKB )
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10 PubMed articles for DACH2 gene :
Search for DACH2
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing DACH2
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
and/or
H-InvDB )
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Other Databases showing DACH2
(According to HUGE )
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--
Specialized Databases showing DACH2 (According to ATLAS , HORDE , IMGT , MTDB, LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
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-- Services for DACH2 (Reagents available from Applied Biosystems , Antibodies and assays by Cell
Signaling Technology , Abcam , Novus Biologicals ,Sigma-Aldrich , R&D Systems , Millipore , Abnova , and/or Invitrogen , Clones available from OriGene ,and/or Invitrogen , Drugs and/or compounds by Sigma-Aldrich , Enzo Life Sciences , and/or Tocris Bioscience )About This Section
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Products for DACH2:
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