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DACH2 Gene

protein-coding   GIFtS: 51
GCID: GC0XP085403

Dachshund Family Transcription Factor 2

(Previous name: dachshund homolog 2 (Drosophila))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dachshund Family Transcription Factor 21 2
Dachshund Homolog 2 (Drosophila)1
Dachshund Homolog 22
Dach23

External Ids:    HGNC: 168141   Entrez Gene: 1171542   Ensembl: ENSG000001267337   OMIM: 3006085   UniProtKB: Q96NX93   

Export aliases for DACH2 gene to outside databases

Previous GC identifers: GC0XP080783 GC0XP082480 GC0XP083439 GC0XP084175 GC0XP085209 GC0XP085290 GC0XP078980


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DACH2 Gene:
This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription
factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein
contains two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal
domain responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to
inactivation by DNA methylation. The encoded protein may be involved in regulation of organogenesis and
myogenesis, and may play a role in premature ovarian failure. Multiple transcript variants encoding different
isoforms have been found for this gene. (provided by RefSeq, Nov 2008)

GeneCards Summary for DACH2 Gene:
DACH2 (dachshund family transcription factor 2) is a protein-coding gene. Diseases associated with DACH2 include allan-herndon-dudley syndrome, and premature ovarian failure. GO annotations related to this gene include nucleotide binding. An important paralog of this gene is DACH1.

UniProtKB/Swiss-Prot: DACH2_HUMAN, Q96NX9
Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1
and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing
cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1
promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be
involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of
DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's
expression (By similarity). Probably binds to DNA via its DACHbox-N domain




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000023.11  NT_011651.18  NC_018934.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DACH2 gene promoter:
         SRF   Pbx1a   SRF (504 AA)   Lmo2   CUTL1   Tal-1beta   HNF-1A   HNF-1   FOXO1a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDACH2 promoter sequence
   Search Chromatin IP Primers for DACH2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DACH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.3   Ensembl cytogenetic band:  Xq21.2   HGNC cytogenetic band: Xq21.3

DACH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DACH2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP085403:  view genomic region     (about GC identifiers)

Start:
85,403,455 bp from pter      End:
86,087,607 bp from pter
Size:
684,153 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: DACH2_HUMAN, Q96NX9 (See protein sequence)
Recommended Name: Dachshund homolog 2  
Size: 599 amino acids; 65323 Da
Subunit: Interacts with SIX6 and EYA2 (By similarity)
Secondary accessions: B1AJV3 B4DQG3 Q8NAY3 Q8ND17 Q96N55
Alternative splicing: 4 isoforms:  Q96NX9-1   Q96NX9-2   Q96NX9-3   Q96NX9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DACH2: NX_Q96NX9

Explore proteomics data for DACH2 at MOPED


See DACH2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (3 alternative transcripts): 
NP_001132986.1  NP_001132987.1  NP_444511.1  

ENSEMBL proteins: 
 ENSP00000362223   ENSP00000421509   ENSP00000426837   ENSP00000362217   ENSP00000420896  
 ENSP00000421919   ENSP00000422727  

DACH2 Human Recombinant Protein Products:

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DACH2 Antibody Products:

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LSBio Antibodies in human, mouse, rat for DACH2

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Cloud-Clone Corp. ELISAs for DACH2
Cloud-Clone Corp. CLIAs for DACH2


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR009061 DNA-bd_dom_put
 IPR003380 Transform_Ski

Graphical View of Domain Structure for InterPro Entry Q96NX9

ProtoNet protein and cluster: Q96NX9

UniProtKB/Swiss-Prot: DACH2_HUMAN, Q96NX9
Domain: The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the
forkhead/winged helix domain (By similarity)
Similarity: Belongs to the DACH/dachshund family


DACH2 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Molecular Function:

     UniProtKB/Swiss-Prot Summary: DACH2_HUMAN, Q96NX9
Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1
and SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing
cyclin-dependent kinase inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1
promoter in embryonal retina. SIX6 corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be
involved together with PAX3, SIX1, and EYA2 in regulation of myogenesis. In the developing somite, expression of
DACH2 and PAX3 is regulated by the overlying ectoderm, and DACH2 and PAX3 positively regulate each other's
expression (By similarity). Probably binds to DNA via its DACHbox-N domain

     Gene Ontology (GO): 2 molecular function terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0000166nucleotide binding ----
GO:0003677DNA binding IEA--
     
DACH2 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for DACH2:
 Decreased viability of wild-ty 

     1 MGI mutant phenotype (inferred from 2 alleles(MGI details for Dach2):
 normal 

DACH2 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Dach2tm1.1Mrd for DACH2

   inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DACH2
   inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DACH2

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DACH2
   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DACH2

miRNA
Products:
    
Block miRNA regulation of human, mouse, rat DACH2 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate DACH2:
hsa-miR-217
SwitchGear 3'UTR luciferase reporter plasmidDACH2 3' UTR sequence
Inhib. RNA
Products:
    
OriGene RNAi products in human, mouse, rat for DACH2
Predesigned siRNA for gene silencing in human, mouse, rat DACH2

Gene Editing
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OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): DACH2 (NM_053281)
Browse Sino Biological Human cDNA Clones
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DACH2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DACH2

Cell Line
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACH2


(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
DACH2_HUMAN, Q96NX9: Nucleus (Probable)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
nucleus4
cytosol2
endoplasmic reticulum1
extracellular1
lysosome1
mitochondrion1

Gene Ontology (GO): 1 cellular component term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005634nucleus IEA--

DACH2 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DACH2
Interactions:

    Search GeneGlobe Interaction Network for DACH2

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

Selected Interacting proteins for DACH2 (Q96NX93 ENSP000003622174) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
InteractantInteraction Details
GeneCardExternal ID(s)
IRF9Q009783, ENSP000003800734I2D: score=1 STRING: ENSP00000380073
KAT2BQ928313, ENSP000002637544I2D: score=1 STRING: ENSP00000263754
NCOR1O753763, ENSP000002687124I2D: score=1 STRING: ENSP00000268712
PAX6ENSP000003684014STRING: ENSP00000368401
PAX2ENSP000003550694STRING: ENSP00000355069
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Gene Ontology (GO): 3 biological process terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0006351transcription, DNA-templated IEA--
GO:0006355regulation of transcription, DNA-templated IEA--
GO:0046545development of primary female sexual characteristics IEA--

DACH2 for ontologies           About GeneDecksing



(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for DACH2



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for DACH2 gene (3 alternative transcripts): 
NM_001139514.1  NM_001139515.1  NM_053281.3  

Unigene Cluster for DACH2:

Dachshund homolog 2 (Drosophila)
Hs.86603  [show with all ESTs]
Unigene Representative Sequence: BC048423
7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000373131(uc004eex.2 uc010nmq.2) ENST00000461604(uc004eew.2)
ENST00000506327 ENST00000373125 ENST00000508860(uc011mra.1) ENST00000510272(uc010nmr.2)
ENST00000484479(uc004eey.3 uc004eez.3)
miRNA
Products:
     
Block miRNA regulation of human, mouse, rat DACH2 using miScript Target Protectors
1 qRT-PCR Assays for microRNA that regulate DACH2:
hsa-miR-217
SwitchGear 3'UTR luciferase reporter plasmidDACH2 3' UTR sequence
Inhib. RNA
Products:
     
OriGene RNAi products in human, mouse, rat for DACH2
Predesigned siRNA for gene silencing in human, mouse, rat DACH2
Clone
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OriGene ORF clones in mouse, rat for DACH2
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
GenScript: all cDNA clones in your preferred vector (see all 3): DACH2 (NM_053281)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for DACH2
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DACH2
Primer
Products:
    
OriGene qSTAR qPCR primer pairs in human, mouse for DACH2
Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DACH2
  QuantiTect SYBR Green Assays in human, mouse, rat DACH2
  QuantiFast Probe-based Assays in human, mouse, rat DACH2

Additional mRNA sequence: 

AF428101.1 AK055953.1 AK091842.1 AK290596.1 AK294498.1 AK295648.1 AK298787.1 AL834456.1 
BC040213.1 BC048423.1 BC114950.1 

6 DOTS entries:

DT.40117719  DT.100019168  DT.406928  DT.101973322  DT.100749541  DT.121302091 

Selected AceView cDNA sequences (see all 26):

AL834456 AF428101 BX107126 AX747214 NM_053281 BQ267186 AA214293 AK091842 
AL712187 AA776596 AK055953 CK906044 BC040213 BQ777896 BQ777596 AI809398 
BC048423 BQ272444 BG704485 AL699905 AW780006 BX471230 BU950092 AA330188 

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for DACH2    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
SP1:        -     -                                                                           
SP2:              -                                                           -               
SP3:                                                                          -               


ECgene alternative splicing isoforms for DACH2

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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DACH2 expression in normal human tissues (normalized intensities)      DACH2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: GCTGCTGCAG
DACH2 Expression
About this image


DACH2 expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database
 selected tissues (see all 7) fully expand
 
 Brain (Nervous System)    fully expand to see all 4 entries
         Cerebral Cortex
 
 Neural Crest (Gastrulation Derivatives)    fully expand to see all 2 entries
         PureStem SK11, NCr-fac & Meso-prx Progenitor
 
 Paraxial Mesoderm (Gastrulation Derivatives)
         PureStem SK11, NCr-fac & Meso-prx Progenitor
 
 Ovary (Reproductive System)
         Oviduct
 
 Pancreas (Endocrine System)
         Islets of Langerhans
DACH2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

DACH2 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.86603
    Custom PCR Arrays for DACH2
Primer
Products:
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Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DACH2
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QuantiFast Probe-based Assays in human, mouse, rat DACH2
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACH2

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of animals.

Orthologs for DACH2 gene from Selected species (see all 13)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Dach21 , 5 dachshund 2 (Drosophila)1, 5 90.37(n)1
93.32(a)1
  X (49.13 cM)5
938371  NM_033605.21  NP_291083.11 
 1132975105 
chicken
(Gallus gallus)
Aves DACH21 dachshund homolog 2 (Drosophila) 77.78(n)
80(a)
  395576  NM_204795.1  NP_990126.1 
lizard
(Anolis carolinensis)
Reptilia DACH26
dachshund homolog 2 (Drosophila)
65(a)
1 ↔ 1
GL343202.1(1315144-1622834)
tropical clawed frog
(Xenopus tropicalis)
Amphibia dach21 dachshund homolog 2 73.31(n)
76.84(a)
  100101662  NM_001110045.1  NP_001103515.1 
zebrafish
(Danio rerio)
Actinopterygii dacha2 dachshund a 74.73(n)   192121  AF427108.1 
fruit fly
(Drosophila melanogaster)
Insecta dac3 mushroom body development RNA
polymerase II transcription more
70(a)   36A1   --
worm
(Caenorhabditis elegans)
Secernentea dac-16
Protein DAC-1, isoform a (dac-1) mRNA, complete cd...
28(a)
1 → many
III(816246-821729) WBGene00000895


ENSEMBL Gene Tree for DACH2 (if available)
TreeFam Gene Tree for DACH2 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Paralogs for DACH2 gene
DACH12  
2 SIMAP similar genes for DACH2 using alignment to 5 protein entries:     DACH2_HUMAN (see all proteins):
FAM175A    DACH1

DACH2 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for DACH2 (see all 10806)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr X posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs2428481,2
C--85401486(-) GCCACG/AAGACA 2 -- us2k1 tfbs33Minor allele frequency- A:0.03MN WA 188
rs1875224341,2
--85401575(+) TTAACC/TCTGTA 2 -- us2k10--------
rs1909158341,2
--85401657(+) GAAGAA/TAATAT 2 -- us2k10--------
rs1833198671,2
C--85401726(+) AAAAGA/GACCCA 2 -- us2k10--------
rs1891704341,2
--85401755(+) TGCTAA/TGTACA 2 -- us2k10--------
rs1436624041,2
C--85401948(+) TTAGAG/TAATGA 2 -- us2k10--------
rs1923032851,2
--85401965(+) TGACAA/GGGAGT 2 -- us2k10--------
rs1846556141,2
--85402034(+) GGGAGC/GCCGAG 2 -- us2k10--------
rs562560251,2
C--85402094(+) TGAAAT/CCCTGT 2 -- us2k11Minor allele frequency- C:0.00NA 1
rs48283651,2
C,A,H--85402140(+) tatatA/Gtatgt 2 -- us2k10--------

HapMap Linkage Disequilibrium report for DACH2 (85403455 - 85653455 bp, first 250kb of DACH2)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for DACH2 (see all 24):    About this table    
Variant IDTypeSubtypePubMed ID
esv2659577CNV Deletion23128226
nsv436631CNV Deletion17901297
esv2227206CNV Deletion18987734
esv2740279CNV Deletion23290073
esv2740276CNV Deletion23290073
esv2740280CNV Deletion23290073
esv2740278CNV Deletion23290073
esv2538515CNV Deletion19546169
esv2164340CNV Deletion18987734
nsv6986CNV Insertion18451855

Locus Specific Mutation Databases (LSDB): DACH2

Site Specific Mutation Identification with PCR Assays
SeqTarget long-range PCR primers for resequencing DACH2
DNA2.0 Custom Variant and Variant Library Synthesis for DACH2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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OMIM gene information: 300608    OMIM disorders: --

6 diseases for DACH2:    About MalaCards
allan-herndon-dudley syndrome    premature ovarian failure    thyroiditis    cerebritis
endotheliitis    prostatitis

2 diseases from the University of Copenhagen DISEASES database for DACH2:
Allan-Herndon-Dudley syndrome     Premature ovarian failure

DACH2 for disorders           About GeneDecksing

Genetic Association Database (GAD): DACH2
Human Genome Epidemiology (HuGE) Navigator: DACH2 (4 documents)

Export disorders for DACH2 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for DACH2 gene, integrated from 10 sources (see all 17):
(articles sorted by number of sources associating them with DACH2)
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  1. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
  2. Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B. (PubMed id 15459172)1, 4 Bione S.... Toniolo D. (Hum. Reprod. 2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
  4. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (Cell 2010)
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (Am. J. Hum. Genet. 2009)
  6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
  7. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PubMed id 17903294)4 Yang Q....O'Donnell C.J. (BMC Med. Genet. 2007)
  8. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
  9. Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. (PubMed id 16917507)1 Aikawa Y....Kitabayashi I. (EMBO J. 2006)
  10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)

(in PubMed, OMIM, and NCBI Bookshelf)
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 117154 HGNC: 16814 AceView: DACH2 Ensembl:ENSG00000126733 euGenes: HUgn117154
ECgene: DACH2 H-InvDB: DACH2

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for DACH2 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for DACH2 gene:
Search GeneIP for patents involving DACH2

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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