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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DACH2 Gene

protein-coding   GIFtS: 55
GCID: GC0XP085403

dachshund homolog 2 (Drosophila)
 Explore 4 diseases affiliated with
DACH2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DACH2    

Aliases
for DACH2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Dachshund Homolog 2 (Drosophila)1 2
Dachshund Homolog 22
Dach23

External Ids:    HGNC: 168141   Entrez Gene: 1171542   Ensembl: ENSG000001267337   OMIM: 3006085   UniProtKB: Q96NX93   

Export aliases for DACH2 gene to outside databases

Previous GC identifers: GC0XP080783 GC0XP082480 GC0XP083439 GC0XP084175 GC0XP085209 GC0XP085290 GC0XP078980


Summaries
for DACH2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DACH2:
This gene is one of two genes which encode a protein similar to the Drosophila protein dachshund, a transcription
factor involved in cell fate determination in the eye, limb and genital disc of the fly. The encoded protein contains
two characteristic dachshund domains: an N-terminal domain responsible for DNA binding and a C-terminal domain
responsible for protein-protein interactions. This gene is located on the X chromosome and is subject to inactivation
by DNA methylation. The encoded protein may be involved in regulation of organogenesis and myogenesis, and may play a
role in premature ovarian failure. Multiple transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Nov 2008)

UniProtKB/Swiss-Prot: DACH2_HUMAN, Q96NX9
Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and
SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase
inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6
corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in
regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying
ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via
its DACHbox-N domain




Genomic Views
for DACH2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000023.10  NC_018934.1  NT_011651.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DACH2 gene promoter:
         SRF   Pbx1a   SRF (504 AA)   Lmo2   CUTL1   Tal-1beta   HNF-1A   HNF-1   FOXO1a   ITF-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DACH2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DACH2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DACH2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xq21.3   Ensembl cytogenetic band:  Xq21.2   HGNC cytogenetic band: Xq21.3

DACH2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DACH2 gene location

GeneLoc information about chromosome X         GeneLoc Exon Structure

GeneLoc location for GC0XP085403:  view genomic region     (about GC identifiers)

Start:
 85,403,455 bp from pter      End:
 86,087,607 bp from pter
Size:
 684,153 bases      Orientation:
 plus strand

Proteins
for DACH2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DACH2_HUMAN, Q96NX9 (See protein sequence)
Recommended Name: Dachshund homolog 2  
Size: 599 amino acids; 65323 Da
Subunit: Interacts with SIX6 and EYA2 (By similarity)
Subcellular location: Nucleus (Probable)
Secondary accessions: B1AJV3 B4DQG3 Q8NAY3 Q8ND17 Q96N55
Alternative splicing: 4 isoforms:  Q96NX9-1   Q96NX9-2   Q96NX9-3   Q96NX9-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for DACH2: NX_Q96NX9

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q96NX9

    • DACH2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (3 alternative transcripts): 
    NP_001132986.1  NP_001132987.1  NP_444511.1  

    ENSEMBL proteins: 
     ENSP00000362223   ENSP00000421509   ENSP00000426837   ENSP00000362217   ENSP00000420896  
     ENSP00000421919   ENSP00000422727  

    Human Recombinant Protein Products: 
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    Novus Biologicals DACH2 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DACH2

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--


    DACH2 for ontologies           About GeneDecksing



    DACH2 Antibody Products: 
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    Uscn Antibodies for DACH2
    ThermoFisher Antibodies for DACH2

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    Uscn ELISAs and CLIAs for DACH2

    Protein Domains /
    Families
    for DACH2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DACH2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR009061 DNA-bd_dom_put
     IPR003380 Transform_Ski

    Graphical View of Domain Structure for InterPro Entry Q96NX9

    ProtoNet protein and cluster: Q96NX9

    UniProtKB/Swiss-Prot: DACH2_HUMAN, Q96NX9
    Domain: The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the
    forkhead/winged helix domain (By similarity)
    Similarity: Belongs to the DACH/dachshund family


    Function
    for DACH2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DACH2_HUMAN, Q96NX9
    Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator for SIX1 and
    SIX6. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase
    inhibitors, including the p27Kip1 promoter. Is recruited with SIX6 to the p27Kip1 promoter in embryonal retina. SIX6
    corepression seems also to involve NCOR1, TBL1, HDAC1 and HDAC3. May be involved together with PAX3, SIX1, and EYA2 in
    regulation of myogenesis. In the developing somite, expression of DACH2 and PAX3 is regulated by the overlying
    ectoderm, and DACH2 and PAX3 positively regulate each other's expression (By similarity). Probably binds to DNA via
    its DACHbox-N domain

    miRNA
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    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DACH2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DACH2:
    hsa-miR-217
    SwitchGear 3'UTR luciferase reporter plasmid: DACH2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DACH2 (see all 4)
    OriGene shRNA RFP: DACH2
    OriGene siRNA: DACH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DACH2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DACH2

    Clone
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    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DACH2 (see all 5)
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    GenScript: all cDNA clones in your preferred vector (see all 3): DACH2 (NM_053281)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DACH2 

    Cell Line
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    Search LifeMap BioReagents cell lines for DACH2

    In Situ Assay
    Products:       
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    Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0003677DNA binding IEA--


    DACH2 for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DACH2:
     Decreased viability of wild-ty 

    Animal Models:
         Mouse knock-out Dach2tm1.1Mrd for DACH2
         1 MGI mutant phenotype (inferred from 2 alleles) (MGI details for Dach2):
     normal 

    DACH2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DACH2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for DACH2

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for DACH2 (Q96NX93 ENSP000003622174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IRF9Q009783, ENSP000003800734I2D: score=1 STRING: ENSP00000380073
    KAT2BQ928313, ENSP000002637544I2D: score=1 STRING: ENSP00000263754
    NCOR1O753763, ENSP000002687124I2D: score=1 STRING: ENSP00000268712
    About this table

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-dependent IEA--
    GO:0006355regulation of transcription, DNA-dependent IEA--
    GO:0046545development of primary female sexual characteristics IEA--


    DACH2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DACH2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DACH2
    Search CenterWatch for drugs/clinical trials and news about DACH2 

    Transcripts
    for DACH2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DACH2 gene (3 alternative transcripts): 
    NM_001139514.1  NM_001139515.1  NM_053281.3  

    Unigene Cluster for DACH2:

    Dachshund homolog 2 (Drosophila)
    Hs.86603  [show with all ESTs]
    Unigene Representative Sequence: BC048423
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000373131(uc004eex.2 uc010nmq.2) ENST00000461604(uc004eew.2)
    ENST00000506327 ENST00000373125 ENST00000508860(uc011mra.1) ENST00000510272(uc010nmr.2)
    ENST00000484479(uc004eey.3 uc004eez.3) ENST00000477378

    miRNA
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    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DACH2
    1 QIAGEN miScript miRNA Assays for microRNA that regulate DACH2:
    hsa-miR-217
    SwitchGear 3'UTR luciferase reporter plasmid: DACH2 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DACH2 (see all 4)
    OriGene shRNA RFP: DACH2
    OriGene siRNA: DACH2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DACH2
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 3): DACH2 (NM_053281)
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    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DACH2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DACH2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DACH2

    Additional cDNA sequence: 

    AF428101.1 AK055953.1 AK091842.1 AK290596.1 AK294498.1 AK295648.1 AK298787.1 AL834456.1 
    BC040213.1 BC048423.1 BC114950.1 

    6 DOTS entries:

    DT.40117719  DT.100019168  DT.406928  DT.101973322  DT.100749541  DT.121302091 

    24/26 AceView cDNA sequences (see all 26):

    AL712187 AX747214 AK091842 BQ267186 BX107126 AA776596 NM_053281 AA214293 
    AF428101 AL834456 AI809398 BQ777596 AL699905 BC048423 BQ272444 BQ777896 
    AW780006 CK906044 BG704485 BC040213 BX471230 AK055953 BU950092 AA330188 

    GeneLoc Exon Structure

    3 Alternative Splicing Database (ASD) splice patterns (SP) for DACH2    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b
    SP1:        -     -                                                                           
    SP2:              -                                                           -               
    SP3:                                                                          -               


    ECgene alternative splicing isoforms for DACH2

    Expression
    for DACH2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DACH2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: GCTGCTGCAG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DACH2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    KidneyInterstitial StromaKidney
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 8 LifeMap Cells 
    NameCategory
    PureStem™ progenitor T42 (Embryonic Progenitor Cell)
    PureStem™ mesenchymal Progenitor SK11 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor SM30 (Embryonic Progenitor Cell)Adipose, Bone, Cartilage
    PureStem™ mesenchymal progenitor 4D20.8 (Embryonic Progenitor Cell)Lateral Plate Mesoderm, Neural Crest
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    PureStem™ progenitor U31 (Embryonic Progenitor Cell)
    PureStem™ progenitor W8 (Embryonic Progenitor Cell)
    PureStem™ progenitor Z1 (Embryonic Progenitor Cell)

    See DACH2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DACH2

    SOURCE GeneReport for Unigene cluster: Hs.86603
        SABiosciences Custom PCR Arrays for DACH2
    Primer
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    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACH2

    Orthologs
    for DACH2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DACH2 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dach21 , 5 dachshund 2 (Drosophila)1, 5 90.26(n)1
    93.49(a)1    		   X (49.13 cM)5
    938371  NM_033605.21  NP_291083.11 
     1132975105 
    chicken
    (Gallus gallus)    		 Aves DACH21 dachshund homolog 2 (Drosophila) 78.15(n)
    80.67(a)    		   395576  NM_204795.1  NP_990126.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DACH26
    		 --
    		 74(a)
    		 1 ↔ 1
    		 GL343202.1(1315585-1622475)
    zebrafish
    (Danio rerio)    		 Actinopterygii dacha2 dachshund a 74.73(n)   192121  AF427108.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta dac3 mushroom body development RNA polymerase II
    transcription more    		 70(a)   36A1   --
    worm
    (Caenorhabditis elegans)    		 Secernentea dac-16
    		 DAChsund transcription factor homolog family membe...
    		 28(a)
    		 1 → many
    		 III(816240-821723)


    ENSEMBL Gene Tree for DACH2 (if available)
    TreeFam Gene Tree for DACH2 (if available) 

    Paralogs
    for DACH2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DACH2 gene
    DACH12  
    2 SIMAP similar genes for DACH2 using alignment to 5 protein entries:     DACH2_HUMAN (see all proteins):
    FAM175A    DACH1

    DACH2 for paralogs           About GeneDecksing



    Genomic Variants
    for DACH2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/9237 NCBI SNPs in DACH2 are shown (see all 9237)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr X posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs2428481,2
    		C,--85401486(-) GCCACG/AAGACA 2 -- us2k1 tfbs33Minor allele frequency- A:0.03MN WA 188
    rs1875224341,2
    		--85401575(+) TTAACC/TCTGTA 2 -- us2k10--------
    rs1909158341,2
    		--85401657(+) GAAGAA/TAATAT 2 -- us2k10--------
    rs1833198671,2
    		--85401726(+) AAAAGA/GACCCA 2 -- us2k10--------
    rs1891704341,2
    		--85401755(+) TGCTAA/TGTACA 2 -- us2k10--------
    rs1436624041,2
    		C,--85401948(+) TTAGAG/TAATGA 2 -- us2k10--------
    rs1923032851,2
    		--85401965(+) TGACAA/GGGAGT 2 -- us2k10--------
    rs1846556141,2
    		--85402034(+) GGGAGC/GCCGAG 2 -- us2k10--------
    rs562560251,2
    		C,--85402094(+) TGAAAT/CCCTGT 2 -- us2k11Minor allele frequency- C:0.00NA 1
    rs48283651,2
    		C,A,H--85402140(+) tatatA/Gtatgt 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for DACH2 (85403455 - 85653455 bp, first 250kb of DACH2)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 8 variations for DACH2
         5 CNVs: 37063 74022 103262 22536 37064
         3 Indels: 41229 41230 47835
    Locus Specific Mutation Databases (LSDB): DACH2

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    Disorders / Diseases
    for DACH2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DACH2 for disorders           About GeneDecksing

    OMIM gene information: 300608    OMIM disorders: --

    4 diseases for DACH2:    About MalaCards
    premature ovarian failure    allan-herndon-dudley syndrome    hematopoiesis    neuronitis

    2 diseases from the University of Copenhagen DISEASES database for DACH2:
    Allan-Herndon-Dudley syndrome     Premature ovarian failure
    Genetic Association Database (GAD): DACH2
    Human Genome Epidemiology (HuGE) Navigator: DACH2 (4 documents)

    Export disorders for DACH2 gene to outside databases

    Publications
    for DACH2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DACH2 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with DACH2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B. (PubMed id 15459172)1, 4 Bione S.... Toniolo D. (2004)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. An atlas of combinatorial transcriptional regulation in mouse and man. (PubMed id 20211142)1 Ravasi T....Hayashizaki Y. (2010)
    4. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1 Bailey S.D....Anand S. (2010)
    5. Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121)1 Talmud P.J.... . (2009)
    6. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    8. Roles of HIPK1 and HIPK2 in AML1- and p300-dependent transcription, hematopoiesis and blood vessel formation. (PubMed id 16917507)1 Aikawa Y....Kitabayashi I. (2006)
    9. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    10. The DNA sequence of the human X chromosome. (PubMed id 15772651)2 Ross M.T.... Bentley D.R. (2005)

    External Searches for DACH2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    OMIM
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    Genome Databases showing DACH2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 117154 HGNC: 16814 AceView: DACH2 Ensembl:ENSG00000126733 euGenes: HUgn117154
    ECgene: DACH2 H-InvDB: DACH2

    Other Databases showing DACH2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DACH2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DACH2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for DACH2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DACH2 gene:
    Search GeneIP for patents involving DACH2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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