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DACH1 Gene

protein-coding   GIFtS: 56
GCID: GC13M072012

Dachshund Family Transcription Factor 1

(Previous names: dachshund homolog (Drosophila), dachshund homolog 1 (Drosophila))
(Previous symbol: DACH)
  See DACH1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dachshund Family Transcription Factor 11 2
DACH1 2 3 5
Dachshund Homolog (Drosophila)1
Dachshund Homolog 1 (Drosophila)1
Dachshund Homolog 12
Dach13

External Ids:    HGNC: 26631   Entrez Gene: 16022   Ensembl: ENSG000001656597   OMIM: 6038035   UniProtKB: Q9UI363   

Export aliases for DACH1 gene to outside databases

Previous GC identifers: GC13M069811 GC13M070910 GC13M052714


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for DACH1 Gene:
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to
regulate gene expression and cell fate determination during development. The protein contains a Ski domain that
is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer,
and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for DACH1 Gene:
DACH1 (dachshund family transcription factor 1) is a protein-coding gene. Diseases associated with DACH1 include postaxial polydactyly, type a2, and postaxial polydactyly type a. GO annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly and nucleotide binding. An important paralog of this gene is DACH2.

UniProtKB/Swiss-Prot: DACH1_HUMAN, Q9UI36
Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1,
SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to
coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to
involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly
repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta
signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By
similarity)

Gene Wiki entry for DACH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000013.10  NC_018924.2  NT_024524.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the DACH1 gene promoter:
         Nkx2-2   NF-kappaB   c-Ets-1   SRY   E2F-1   E2F   Ik-2   IRF-7A   Chx10   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDACH1 promoter sequence
   Search Chromatin IP Primers for DACH1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DACH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22   Ensembl cytogenetic band:  13q21.33   HGNC cytogenetic band: 13q22

DACH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DACH1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M072012:  view genomic region     (about GC identifiers)

Start:
72,012,098 bp from pter      End:
72,441,330 bp from pter
Size:
429,233 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: DACH1_HUMAN, Q9UI36 (See protein sequence)
Recommended Name: Dachshund homolog 1  
Size: 760 amino acids; 78676 Da
Subunit: Interacts with SIX1, SIX6 and EYA3. Interacts with NCOR1 and HDAC3 through its N-terminus. Interacts with
SIN3A through its C-terminus (By similarity). Interacts with SMAD3 and SMAD4
Sequence caution: Sequence=CAA06666.1; Type=Erroneous initiation; Sequence=CAC12840.2; Type=Erroneous gene model
prediction; Sequence=CAH73005.1; Type=Erroneous gene model prediction; Sequence=CAH73006.1; Type=Erroneous gene
model prediction; Sequence=CAH73303.1; Type=Erroneous gene model prediction; Sequence=CAH73304.1; Type=Erroneous
gene model prediction; Sequence=CAI14979.1; Type=Erroneous gene model prediction; Sequence=CAI14980.1;
Type=Erroneous gene model prediction; Sequence=CAI16673.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for DACH1:
1L8R (3D)    
Secondary accessions: D0FY35 D0FY36 O75523 O75687 Q5VYY3 Q5VYY4 Q96SG3 Q96SG4 Q9H524 Q9UMH4
Alternative splicing: 4 isoforms:  Q9UI36-1   Q9UI36-2   Q9UI36-3   Q9UI36-4   (Major)

Explore the universe of human proteins at neXtProt for DACH1: NX_Q9UI36

Explore proteomics data for DACH1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys653, Lys668
  • Modification sites at PhosphoSitePlus

  • See DACH1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_004383.3  NP_542937.2  NP_542938.2  

    ENSEMBL proteins: 
     ENSP00000304994   ENSP00000352712   ENSP00000318506   ENSP00000346604  

    DACH1 Human Recombinant Protein Products:

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    Browse Sino Biological Cell Lysates
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    Cloud-Clone Corp. Proteins for DACH1

     
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    DACH1 Assay Products:

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    Search eBioscience for ELISAs for DACH1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR009061 DNA-bd_dom_put
     IPR003380 Transform_Ski

    Graphical View of Domain Structure for InterPro Entry Q9UI36

    ProtoNet protein and cluster: Q9UI36

    UniProtKB/Swiss-Prot: DACH1_HUMAN, Q9UI36
    Domain: The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the
    forkhead/winged helix domain
    Similarity: Belongs to the DACH/dachshund family


    Find genes that share domains with DACH1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DACH1_HUMAN, Q9UI36
    Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1,
    SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to
    coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to
    involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly
    repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta
    signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By
    similarity)

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0001075RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly IEA--
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA--
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
         
    Find genes that share ontologies with DACH1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for DACH1:
     Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dach1):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  nervous system 
     respiratory system 

    Find genes that share phenotypes with DACH1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for DACH1: Dach1tm1Mrd Dach1tm1Krs

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for DACH1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for DACH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DACH1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DACH1

    miRNA
    Products:
        
    miRTarBase miRNAs that target DACH1:
    hsa-mir-335-5p (MIRT018559)

    Block miRNA regulation of human, mouse, rat DACH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DACH1 (see all 85):
    hsa-miR-376b hsa-miR-300 hsa-miR-4305 hsa-miR-134 hsa-miR-374a hsa-miR-342-3p hsa-miR-508-5p hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidDACH1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DACH1
    Predesigned siRNA for gene silencing in human, mouse, rat DACH1

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for DACH1

    Clone
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    OriGene ORF clones in mouse, rat for DACH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DACH1 (NM_080759)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DACH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DACH1

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DACH1 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACH1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    DACH1_HUMAN, Q9UI36: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol2
    endoplasmic reticulum1
    extracellular1
    mitochondrion1

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005667transcription factor complex IEA--
    GO:0005730nucleolus ----
    GO:0005737cytoplasm IEA--

    Find genes that share ontologies with DACH1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including DACH1: 
              Stem Cell Transcription Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for DACH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DACH1 (Q9UI361, 3 ENSP000003527124) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NAGKQ9UJ701, 3, ENSP000002442044EBI-347111,EBI-372578 I2D: score=4 STRING: ENSP00000244204
    NCOR1O753761, 3, ENSP000002687124EBI-347111,EBI-347233 I2D: score=4 STRING: ENSP00000268712
    SMAD4Q134851, 3, ENSP000003415514EBI-347111,EBI-347263 I2D: score=2 STRING: ENSP00000341551
    UBE2IP632793, ENSP000003248974I2D: score=5 STRING: ENSP00000324897
    SMAD3P840223, ENSP000003329734I2D: score=2 STRING: ENSP00000332973
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
    GO:0001967suckling behavior IEA--
    GO:0006355regulation of transcription, DNA-templated ----
    GO:0007585respiratory gaseous exchange IEA--
    GO:0008283cell proliferation IEA--

    Find genes that share ontologies with DACH1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DACH1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DACH1 gene (3 alternative transcripts): 
    NM_004392.5  NM_080759.4  NM_080760.4  

    Unigene Cluster for DACH1:

    Dachshund homolog 1 (Drosophila)
    Hs.129452  [show with all ESTs]
    Unigene Representative Sequence: NM_080759
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305425(uc021rkj.1) ENST00000359684 ENST00000313174(uc021rkk.1)
    ENST00000354591(uc021rkl.1)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DACH1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DACH1 (see all 85):
    hsa-miR-376b hsa-miR-300 hsa-miR-4305 hsa-miR-134 hsa-miR-374a hsa-miR-342-3p hsa-miR-508-5p hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidDACH1 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DACH1
    Predesigned siRNA for gene silencing in human, mouse, rat DACH1
    Clone
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    OriGene ORF clones in mouse, rat for DACH1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): DACH1 (NM_080759)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DACH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DACH1
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for DACH1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DACH1
      QuantiTect SYBR Green Assays in human, mouse, rat DACH1
      QuantiFast Probe-based Assays in human, mouse, rat DACH1

    Additional mRNA sequence: 

    AF069509.1 AF102546.1 AF356492.1 AJ005670.1 AK001000.1 AL079278.1 BC021219.2 

    16 DOTS entries:

    DT.111486  DT.100025625  DT.120782525  DT.120782470  DT.120782500  DT.92423852  DT.87046178  DT.95129743 
    DT.100695640  DT.100695642  DT.120933407  DT.121236364  DT.87018230  DT.95139642  DT.95223619  DT.97864380 

    1 AceView cDNA sequence:

    R74591 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DACH1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGACCTAT
    DACH1 Expression
    About this image


    DACH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 12) fully expand
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Metencephalon
             Floor plate-like cells
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Granulocytes Peripheral Blood
     
     Brain (Nervous System)    fully expand to see all 3 entries
             Medulla Oblongata
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Lens Placode Cells Lens Placode
             Retina
     
     Thymus (Hematopoietic System)
             T Helper Cells Thymus
    DACH1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DACH1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.129452

    UniProtKB/Swiss-Prot: DACH1_HUMAN, Q9UI36
    Tissue specificity: Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen.
    Isoform 3 is found in liver and heart. Isoform 4 is found in spleen

        Pathway & Disease-focused RT2 Profiler PCR Array including DACH1: 
              Stem Cell Transcription Factors in human mouse rat

    Primer
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DACH1
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DACH1 gene from Selected species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dach11 , 5 dachshund 1 (Drosophila)1, 5 90.76(n)1
    95.55(a)1
      14 (48.25 cM)5
    131341  NM_007826.31  NP_031852.11 
     977868535 
    chicken
    (Gallus gallus)
    Aves DACH11 dachshund homolog 1 (Drosophila) 88.77(n)
    98.16(a)
      373935  NM_001199446.1  NP_001186375.1 
    lizard
    (Anolis carolinensis)
    Reptilia DACH16
    dachshund homolog 1 (Drosophila)
    70(a)
    1 ↔ 1
    3(82506446-82912520)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ063320.12   -- 81.52(n)    BJ063320.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dachc2 dachshund c 75.75(n)   192123  AF427110.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dac6
    dachshund
    17(a)
    1 → many
    2L(16466512-16485984)
    worm
    (Caenorhabditis elegans)
    Secernentea dac-16
    Protein DAC-1, isoform a (dac-1) mRNA, complete cd...
    30(a)
    1 → many
    III(816246-821729) WBGene00000895


    ENSEMBL Gene Tree for DACH1 (if available)
    TreeFam Gene Tree for DACH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DACH1 gene
    DACH22  
    1 SIMAP similar gene for DACH1 using alignment to 1 protein entry:     DACH1_HUMAN:
    DACH2

    Find genes that share paralogs with DACH1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DACH1 (see all 7840)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925247691,2
    Cuntested153261823(+) AAAAGC/TGATGA 3 -- int10--------
    rs1408936001,2
    --52914455(+) TCCATC/GAACAT 3 -- ds50010--------
    rs1906704011,2
    --52914466(+) GTCTAC/TTTTGC 3 -- ds50010--------
    rs170882371,2
    C,F,H--52914469(+) TACTTT/CGCATT 3 -- ds50018Minor allele frequency- C:0.01NA NS EA WA 680
    rs776171651,2
    C,F--52914475(+) GCATTA/CTTCAG 3 -- ds50012Minor allele frequency- C:0.16CSA WA 120
    rs98055801,2
    H--52914537(+) AAGGTA/CCAAAT 3 -- ds50014Minor allele frequency- C:0.00NS EA 414
    rs1832153451,2
    --52914593(+) TGTGGA/GCAGTT 3 -- ds50010--------
    rs1880770801,2
    --52914612(+) TGGCAA/GGAAAC 3 -- ds50010--------
    rs732133771,2
    C,F--52914682(+) TCACCA/GCAGTA 3 -- ds50011Minor allele frequency- G:0.03NA 120
    rs73354411,2
    C,F,A,H--52914700(+) TTAGAG/AATAGA 3 -- ds500120Minor allele frequency- A:0.09NA NS EA WA 2480

    HapMap Linkage Disequilibrium report for DACH1 (72012098 - 72262098 bp, first 250kb of DACH1)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for DACH1 (see all 47):    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv257e201CNV Deletion23290073
    esv2747605CNV Deletion23290073
    dgv361e199CNV Deletion23128226
    esv2747621CNV Deletion23290073
    esv2747623CNV Deletion23290073
    esv2747624CNV Deletion23290073
    esv2747602CNV Deletion23290073
    esv1241719CNV Deletion17803354
    dgv259e201CNV Deletion23290073
    dgv258e201CNV Deletion23290073

    Human Gene Mutation Database (HGMD): DACH1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing DACH1
    DNA2.0 Custom Variant and Variant Library Synthesis for DACH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603803    OMIM disorders: --

    3 diseases for DACH1:    
    About MalaCards
    postaxial polydactyly, type a2    postaxial polydactyly type a    anophthalmia/microphthalmia


    Find genes that share disorders with DACH1           About GenesLikeMe

    GeneTests: DACH1
    GeneReviews: DACH1
    Genetic Association Database (GAD): DACH1
    Human Genome Epidemiology (HuGE) Navigator: DACH1 (6 documents)

    Export disorders for DACH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DACH1 gene, integrated from 10 sources (see all 58):
    (articles sorted by number of sources associating them with DACH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2, 3 Dunham A.... Ross M.T. (Nature 2004)
    2. DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. (PubMed id 14525983)1, 2, 9 Wu K.... Pestell R.G. (J. Biol. Chem. 2003)
    3. Dach: genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the mouse homolog. (PubMed id 11543628)1, 2, 9 Ayres J.A.... Nuckolls G.H. (Genomics 2001)
    4. Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. (PubMed id 22379998)1, 4 McCormack M....Cavalleri G.L. (Pharmacogenomics 2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    6. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1, 4 KAPttgen A....Fox C.S. (Nat. Genet. 2010)
    7. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    9. Structure of the retinal determination protein dachshund reveals a DNA binding motif. (PubMed id 12057194)1, 2 Kim S.-S....Hegde R.S. (Structure 2002)
    10. Localization of the human homologue of the Drosophila dachshund gene (DACH) to chromosome 13q21. (PubMed id 10395809)1, 3 Kozmik Z. and Cvekl A. (Genomics 1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 1602 HGNC: 2663 AceView: DACH1.2 Ensembl:ENSG00000165659 euGenes: HUgn1602
    ECgene: DACH1 H-InvDB: DACH1

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for DACH1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/books/NBK1116/?term=DACH1[genesymbol]

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for DACH1 gene:
    Search GeneIP for patents involving DACH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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