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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DACH1 Gene

protein-coding   GIFtS: 55
GCID: GC13M072012

Dachshund Homolog 1 (Drosophila)

(Previous name: dachshund homolog (Drosophila))
(Previous symbol: DACH)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dachshund Homolog 1 (Drosophila)1 2
DACH1 2 3 5
Dachshund Homolog (Drosophila)1
Dachshund Homolog 12
Dach13

External Ids:    HGNC: 26631   Entrez Gene: 16022   Ensembl: ENSG000001656597   OMIM: 6038035   UniProtKB: Q9UI363   

Export aliases for DACH1 gene to outside databases

Previous GC identifers: GC13M069811 GC13M070910 GC13M052714


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DACH1 Gene:
This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to
regulate gene expression and cell fate determination during development. The protein contains a Ski domain that
is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer,
and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Sep 2009)

GeneCards Summary for DACH1 Gene: 
DACH1 (dachshund homolog 1 (Drosophila)) is a protein-coding gene. Diseases associated with DACH1 include branchiooculofacial syndrome, and postaxial polydactyly type a. GO annotations related to this gene include RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly and nucleotide binding. An important paralog of this gene is DACH2.

UniProtKB/Swiss-Prot: DACH1_HUMAN, Q9UI36
Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1,
SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to
coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to
involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly
repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta
signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By
similarity)

Gene Wiki entry for DACH1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000013.10  NC_018924.2  NT_024524.14  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DACH1 gene promoter:
         Nkx2-2   NF-kappaB   c-Ets-1   SRY   E2F-1   E2F   Ik-2   IRF-7A   Chx10   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDACH1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DACH1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DACH1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22   Ensembl cytogenetic band:  13q21.33   HGNC cytogenetic band: 13q22

DACH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DACH1 gene location

GeneLoc information about chromosome 13         GeneLoc Exon Structure

GeneLoc location for GC13M072012:  view genomic region     (about GC identifiers)

Start:
72,012,098 bp from pter      End:
72,441,330 bp from pter
Size:
429,233 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DACH1_HUMAN, Q9UI36 (See protein sequence)
Recommended Name: Dachshund homolog 1  
Size: 760 amino acids; 78676 Da
Subunit: Interacts with SIX1, SIX6 and EYA3. Interacts with NCOR1 and HDAC3 through its N-terminus. Interacts with
SIN3A through its C-terminus (By similarity). Interacts with SMAD3 and SMAD4
Subcellular location: Nucleus
Sequence caution: Sequence=CAA06666.1; Type=Erroneous initiation; Sequence=CAC12840.2; Type=Erroneous gene model
prediction; Sequence=CAH73005.1; Type=Erroneous gene model prediction; Sequence=CAH73006.1; Type=Erroneous gene
model prediction; Sequence=CAH73303.1; Type=Erroneous gene model prediction; Sequence=CAH73304.1; Type=Erroneous
gene model prediction; Sequence=CAI14979.1; Type=Erroneous gene model prediction; Sequence=CAI14980.1;
Type=Erroneous gene model prediction; Sequence=CAI16673.1; Type=Erroneous gene model prediction;
1 PDB 3D structure from and Proteopedia for DACH1:
1L8R (3D)    
Secondary accessions: D0FY35 D0FY36 O75523 O75687 Q5VYY3 Q5VYY4 Q96SG3 Q96SG4 Q9H524 Q9UMH4
Alternative splicing: 4 isoforms:  Q9UI36-1   Q9UI36-2   Q9UI36-3   Q9UI36-4   (Major)

Explore the universe of human proteins at neXtProt for DACH1: NX_Q9UI36

Explore proteomics data for DACH1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9UI36

  • DACH1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DACH1 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_004383.3  NP_542937.2  NP_542938.2  

    ENSEMBL proteins: 
     ENSP00000304994   ENSP00000352712   ENSP00000318506   ENSP00000346604  

    Human Recombinant Protein Products for DACH1: 
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    Novus Biologicals DACH1 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DACH1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005667transcription factor complex IEA--
    GO:0005730nucleolus IDA--
    GO:0005737cytoplasm IEA--

    DACH1 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. CLIAs for DACH1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    2 InterPro protein domains:
     IPR009061 DNA-bd_dom_put
     IPR003380 Transform_Ski

    Graphical View of Domain Structure for InterPro Entry Q9UI36

    ProtoNet protein and cluster: Q9UI36

    UniProtKB/Swiss-Prot: DACH1_HUMAN, Q9UI36
    Domain: The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the
    forkhead/winged helix domain
    Similarity: Belongs to the DACH/dachshund family


    DACH1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DACH1_HUMAN, Q9UI36
    Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1,
    SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to
    coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to
    involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly
    repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta
    signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By
    similarity)

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding IEA--
    GO:0001075RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly IEA--
    GO:0001078RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA--
    GO:0003677DNA binding IEA--
    GO:0003700sequence-specific DNA binding transcription factor activity ----
         
    DACH1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for DACH1:
     Increased HPV18 LCR reporter a  Synthetic lethal with Ras 

         6 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Dach1):
     behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  mortality/aging  nervous system 
     respiratory system 

    DACH1 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for DACH1: Dach1tm1Mrd Dach1tm1Krs

       inGenious Targeting Laboratory - Custom generated mouse model solutions for DACH1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DACH1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DACH1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DACH1 

    miRNA
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    hsa-miR-376b hsa-miR-300 hsa-miR-4305 hsa-miR-134 hsa-miR-374a hsa-miR-342-3p hsa-miR-508-5p hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidDACH1 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Gene Editing
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DACH1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

    5/17 Interacting proteins for DACH1 (Q9UI361, 3 ENSP000003527124) via UniProtKB, MINT, STRING, and/or I2D (see all 17)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    NCOR1O753761, 3, ENSP000002687124EBI-347111,EBI-347233 I2D: score=4 STRING: ENSP00000268712
    SMAD4Q134851, 3, ENSP000003415514EBI-347111,EBI-347263 I2D: score=2 STRING: ENSP00000341551
    UBE2IP632793, ENSP000003248974I2D: score=5 STRING: ENSP00000324897
    NAGKQ9UJ703, ENSP000002442044I2D: score=4 STRING: ENSP00000244204
    SMAD3P840223, ENSP000003329734I2D: score=2 STRING: ENSP00000332973
    About this table

    Gene Ontology (GO): 5/11 biological process terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter ----
    GO:0001967suckling behavior IEA--
    GO:0006355regulation of transcription, DNA-dependent ----
    GO:0007585respiratory gaseous exchange IEA--
    GO:0008283cell proliferation IEA--

    DACH1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DACH1

    Search CenterWatch for drugs/clinical trials and news about DACH1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DACH1 gene (3 alternative transcripts): 
    NM_004392.5  NM_080759.4  NM_080760.4  

    Unigene Cluster for DACH1:

    Dachshund homolog 1 (Drosophila)
    Hs.129452  [show with all ESTs]
    Unigene Representative Sequence: NM_080759
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000305425(uc021rkj.1) ENST00000359684 ENST00000313174(uc021rkk.1)
    ENST00000354591(uc021rkl.1)
    miRNA
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    8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate DACH1 (see all 85):
    hsa-miR-376b hsa-miR-300 hsa-miR-4305 hsa-miR-134 hsa-miR-374a hsa-miR-342-3p hsa-miR-508-5p hsa-miR-155*
    SwitchGear 3'UTR luciferase reporter plasmidDACH1 3' UTR sequence
    Inhib. RNA
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    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DACH1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DACH1
    Clone
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    OriGene clones in human, mouse for DACH1 (see all 25)
    OriGene ORF clones in mouse, rat for DACH1
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    GenScript: all cDNA clones in your preferred vector (see all 3): DACH1 (NM_080759)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DACH1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DACH1
    Sirion Biotech Customized lentivirus for stable overexpression of DACH1 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DACH1

    Additional mRNA sequence: 

    AF069509.1 AF102546.1 AF356492.1 AJ005670.1 AK001000.1 AL079278.1 BC021219.2 

    16 DOTS entries:

    DT.111486  DT.100025625  DT.120782525  DT.120782470  DT.120782500  DT.92423852  DT.87046178  DT.95129743 
    DT.100695640  DT.100695642  DT.120933407  DT.121236364  DT.87018230  DT.95139642  DT.95223619  DT.97864380 

    1 AceView cDNA sequence:

    R74591 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DACH1 expression in normal human tissues (normalized intensities)      DACH1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAGGACCTAT
    DACH1 Expression
    About this image


    DACH1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/22 selected tissues (see all 22) fully expand
     
     Brain (Nervous System)    fully expand to see all 11 entries
             Medulla Oblongata
             brain/forebrain/diencephalon   
     
     Neural Tube (Nervous System)    fully expand to see all 7 entries
             Telencephalon
             brain/midbrain/lateral wall   
     
     Lower Urinary Tract (Urinary System)    fully expand to see all 6 entries
             Ureter
             visceral organ/bladder   
     
     Kidney (Urinary System)    fully expand to see all 4 entries
             Human Renal Proximal Tubular Epithelial Cells (HRPTEpiC)   
             visceral organ/metanephros/calyx   
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             T Helper Cells Thymus
             cd49a+ cells   

    See DACH1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DACH1

    SOURCE GeneReport for Unigene cluster: Hs.129452

    UniProtKB/Swiss-Prot: DACH1_HUMAN, Q9UI36
    Tissue specificity: Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen.
    Isoform 3 is found in liver and heart. Isoform 4 is found in spleen

        SABiosciences Expression via Pathway-Focused PCR Array including DACH1: 
              Stem Cell Transcription Factors in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACH1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DACH1 gene from 7/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Dach11 , 5 dachshund 1 (Drosophila)1, 5 92.27(n)1
    97.98(a)1
      14 (48.25 cM)5
    131341  NM_007826.21  NP_031852.11 
     977868535 
    chicken
    (Gallus gallus)
    Aves DACH11 dachshund homolog 1 (Drosophila) 86.75(n)
    93.58(a)
      373935  NM_001199446.1  NP_001186375.1 
    lizard
    (Anolis carolinensis)
    Reptilia DACH16
    dachshund homolog 1 (Drosophila)
    73(a)
    1 ↔ 1
    3(82506446-82912520)
    African clawed frog
    (Xenopus laevis)
    Amphibia BJ063320.12   -- 81.52(n)    BJ063320.1 
    zebrafish
    (Danio rerio)
    Actinopterygii dachc2 dachshund c 75.75(n)   192123  AF427110.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta dac6
    dachshund
    16(a)
    1 → many
    2L(16466512-16485984)
    worm
    (Caenorhabditis elegans)
    Secernentea dac-16
    Protein DAC-1, isoform a
    27(a)
    1 → many
    III(816246-821729)


    ENSEMBL Gene Tree for DACH1 (if available)
    TreeFam Gene Tree for DACH1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DACH1 gene
    DACH22  
    1 SIMAP similar gene for DACH1 using alignment to 1 protein entry:     DACH1_HUMAN:
    DACH2

    DACH1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/7840 SNPs in DACH1 are shown (see all 7840)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 13 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1925247691,2
    Cuntested153261823(+) AAAAGC/TGATGA 3 -- int10--------
    rs1408936001,2
    --52914455(+) TCCATC/GAACAT 3 -- ds50010--------
    rs1906704011,2
    --52914466(+) GTCTAC/TTTTGC 3 -- ds50010--------
    rs170882371,2
    C,F,H--52914469(+) TACTTT/CGCATT 3 -- ds50018Minor allele frequency- C:0.01NA NS EA WA 680
    rs776171651,2
    C,F--52914475(+) GCATTA/CTTCAG 3 -- ds50012Minor allele frequency- C:0.16CSA WA 120
    rs98055801,2
    H--52914537(+) AAGGTA/CCAAAT 3 -- ds50014Minor allele frequency- C:0.00NS EA 414
    rs1832153451,2
    --52914593(+) TGTGGA/GCAGTT 3 -- ds50010--------
    rs1880770801,2
    --52914612(+) TGGCAA/GGAAAC 3 -- ds50010--------
    rs732133771,2
    C,F--52914682(+) TCACCA/GCAGTA 3 -- ds50011Minor allele frequency- G:0.03NA 120
    rs73354411,2
    C,F,A,H--52914700(+) TTAGAG/AATAGA 3 -- ds500120Minor allele frequency- A:0.09NA NS EA WA 2480

    HapMap Linkage Disequilibrium report for DACH1 (72012098 - 72262098 bp, first 250kb of DACH1)

    Structural Variations
         Database of Genomic Variants (DGV) 10/47 variations for DACH1 (see all 47):    About this table     
    Variant IDTypeSubtypePubMed ID
    dgv257e201CNV Deletion23290073
    esv2747605CNV Deletion23290073
    dgv361e199CNV Deletion23128226
    esv2747621CNV Deletion23290073
    esv2747623CNV Deletion23290073
    esv2747624CNV Deletion23290073
    esv2747602CNV Deletion23290073
    esv1241719CNV Deletion17803354
    dgv259e201CNV Deletion23290073
    dgv258e201CNV Deletion23290073


    Human Gene Mutation Database (HGMD): DACH1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DACH1
    DNA2.0 Custom Variant and Variant Library Synthesis for DACH1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603803    OMIM disorders: --

    20/22 diseases for DACH1 (see all 22):    About MalaCards
    branchiooculofacial syndrome    postaxial polydactyly type a    branchiootorenal syndrome    reticulosarcoma
    anophthalmia/microphthalmia    polydactyly    endometritis    malignant peripheral nerve sheath tumor
    microphthalmia    obsessive-compulsive disorder    clear cell renal cell carcinoma    renal cell carcinoma
    endometrial carcinoma    kidney disease    myeloid leukemia    retinitis
    gastric cancer    ovarian cancer    prostate cancer    prostatitis


    DACH1 for disorders           About GeneDecksing

    GeneTests: DACH1
    GeneReviews: DACH1
    Genetic Association Database (GAD): DACH1
    Human Genome Epidemiology (HuGE) Navigator: DACH1 (6 documents)

    Export disorders for DACH1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DACH1 gene, integrated from 9 sources (see all 57):
    (articles sorted by number of sources associating them with DACH1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)1, 2, 3 Dunham A.... Ross M.T. (2004)
    2. DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. (PubMed id 14525983)1, 2, 9 Wu K.... Pestell R.G. (2003)
    3. Dach: genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the mouse homolog. (PubMed id 11543628)1, 2, 9 Ayres J.A.... Nuckolls G.H. (2001)
    4. Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions. (PubMed id 22379998)1, 4 McCormack M....Cavalleri G.L. (2012)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    6. New loci associated with kidney function and chronic kidney disease. (PubMed id 20383146)1, 4 KAPttgen A....Fox C.S. (2010)
    7. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    8. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    9. Structure of the retinal determination protein dachshund reveals a DNA binding motif. (PubMed id 12057194)1, 2 Kim S.-S....Hegde R.S. (2002)
    10. Localization of the human homologue of the Drosophila dachshund gene (DACH) to chromosome 13q21. (PubMed id 10395809)1, 3 Kozmik Z. and Cvekl A. (1999)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1602 HGNC: 2663 AceView: DACH1.2 Ensembl:ENSG00000165659 euGenes: HUgn1602
    ECgene: DACH1 H-InvDB: DACH1

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DACH1 Pharmacogenomics, SNPs, Pathways
    GeneReviewshttp://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DACH1

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DACH1 gene:
    Search GeneIP for patents involving DACH1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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