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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DACH1 Gene

protein-coding GIFtS: 53
GCID: GC13M072012

dachshund homolog 1 (Drosophila)

(Previous name: dachshund homolog (Drosophila) )
(Previous symbol: DACH)

Explore 21 diseases affiliated with
DACH1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dachshund Homolog 1 (Drosophila)¹ ²
DACH¹ ² ³ ⁵
Dachshund Homolog (Drosophila)¹
Dachshund Homolog 1²
Dach1³

External Ids:	HGNC: 2663¹	Entrez Gene: 1602²	Ensembl: ENSG00000165659⁷	OMIM: 603803⁵	UniProtKB: Q9UI36³

Export aliases for DACH1 gene to outside databases

Previous GC identifers: GC13M069811 GC13M070910 GC13M052714

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DACH1:

This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to

regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is

highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is

correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this

gene. (provided by RefSeq, Sep 2009)

UniProtKB/Swiss-Prot: DACH1_HUMAN, Q9UI36

Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6

and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation

through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of

CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent

kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction

with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity)

Gene Wiki entry for DACH1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000013.10 NC_018924.1 NT_024524.14

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DACH1 gene promoter:
Nkx2-2 NF-kappaB c-Ets-1 SRY E2F-1 E2F Ik-2 IRF-7A Chx10 NF-kappaB1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DACH1 promoter sequence

Search SABiosciences Chromatin IP Primers for DACH1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DACH1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 13q22 Ensembl cytogenetic band: 13q21.33 HGNC cytogenetic band: 13q22

DACH1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DACH1 gene location

GeneLoc information about chromosome 13 GeneLoc Exon Structure

GeneLoc location for GC13M072012: view genomic region (about GC identifiers)

Start:	72,012,098 bp from pter	End:	72,441,330 bp from pter
Size:	429,233 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DACH1_HUMAN, Q9UI36 (See protein sequence)

Recommended Name: Dachshund homolog 1

Size: 758 amino acids; 78562 Da

Subunit: Interacts with SIX1, SIX6 and EYA3. Interacts with NCOR1 and HDAC3 through its N-terminus. Interacts with

SIN3A through its C-terminus (By similarity). Interacts with SMAD3 and SMAD4

Subcellular location: Nucleus

Sequence caution: Sequence=CAA06666.1; Type=Erroneous initiation; Sequence=CAC12840.2; Type=Erroneous gene model

prediction; Sequence=CAH73005.1; Type=Erroneous gene model prediction; Sequence=CAH73006.1; Type=Erroneous gene model

prediction; Sequence=CAH73303.1; Type=Erroneous gene model prediction; Sequence=CAH73304.1; Type=Erroneous gene model

prediction; Sequence=CAI14979.1; Type=Erroneous gene model prediction; Sequence=CAI14980.1; Type=Erroneous gene model

prediction; Sequence=CAI16673.1; Type=Erroneous gene model prediction;

1 PDB 3D structure from and Proteopedia for DACH1:

1L8R (3D)

Secondary accessions: O75523 O75687 Q5VYY3 Q5VYY4 Q96SG3 Q96SG4 Q9H524 Q9UMH4

Alternative splicing: 4 isoforms: Q9UI36-1 Q9UI36-2 Q9UI36-3 Q9UI36-4 (Major)

Explore the universe of human proteins at neXtProt for DACH1: NX_Q9UI36

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9UI36

DACH1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_004383.3 NP_542937.2 NP_542938.2

ENSEMBL proteins:

ENSP00000304994 ENSP00000352712 ENSP00000318506 ENSP00000346604

Human Recombinant Protein Products:

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	Uscn Proteins for DACH1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005634	nucleus	IDA	--
GO:0005667	transcription factor complex	IEA	--
GO:0005730	nucleolus	IDA	--
GO:0005737	cytoplasm	IEA	--

DACH1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DACH1 for domains About GeneDecksing

2 InterPro domains/families:

IPR009061 DNA-bd_dom_put

IPR003380 Transform_Ski

Graphical View of Domain Structure for InterPro Entry Q9UI36

ProtoNet protein and cluster: Q9UI36

UniProtKB/Swiss-Prot: DACH1_HUMAN, Q9UI36

Domain: The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the

forkhead/winged helix domain

Similarity: Belongs to the DACH/dachshund family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: DACH1_HUMAN, Q9UI36

Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6

and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation

through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of

CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent

kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction

with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity)

miRNA Products:		OriGene 3'-UTR Clone (see all 3): DACH1 Browse MicroRNA Expression Plasmids
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		8/85 QIAGEN miScript miRNA Assays for microRNAs that regulate DACH1 (see all 85):
		hsa-miR-376b hsa-miR-300 hsa-miR-4305 hsa-miR-134 hsa-miR-374a hsa-miR-342-3p hsa-miR-508-5p hsa-miR-155*

		SwitchGear 3'UTR luciferase reporter plasmid: DACH1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DACH1

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000166	nucleotide binding	IEA	--
GO:0001075	RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly	IEA	--
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription	IDA	--
GO:0003677	DNA binding	IEA	--
GO:0003700	sequence-specific DNA binding transcription factor activity	--	--

DACH1 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for DACH1:

Increased HPV18 LCR reporter a

Synthetic lethal with Ras

Animal Models:
Mouse knock-outs for DACH1: Dach1^tm1Mrd Dach1^tm1Krs
6 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dach1):

behavior/neurological	endocrine/exocrine gland	homeostasis/metabolism	mortality/aging	nervous system
respiratory system

DACH1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DACH1

STRING Interaction Network Preview (showing 5 interactants - click image to see 17)

5/17 Interacting proteins for DACH1 (Q9UI36^{1, 3} ENSP00000352712⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 17)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NCOR1	O75376¹^,³, ENSP00000268712⁴	EBI-347111,EBI-347233 I2D: score=4 STRING: ENSP00000268712
SMAD4	Q13485¹^,³, ENSP00000341551⁴	EBI-347111,EBI-347263 I2D: score=2 STRING: ENSP00000341551
UBE2I	P63279³, ENSP00000324897⁴	I2D: score=5 STRING: ENSP00000324897
NAGK	Q9UJ70³, ENSP00000244204⁴	I2D: score=4 STRING: ENSP00000244204
SMAD3	P84022³, ENSP00000332973⁴	I2D: score=2 STRING: ENSP00000332973

About this table

Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	--	--
GO:0001967	suckling behavior	IEA	--
GO:0006355	regulation of transcription, DNA-dependent	--	--
GO:0007275	multicellular organismal development	--	--
GO:0007585	respiratory gaseous exchange	IEA	--

DACH1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DACH1
Search CenterWatch for drugs/clinical trials and news about DACH1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DACH1 gene (3 alternative transcripts):

NM_004392.5 NM_080759.4 NM_080760.4

Unigene Cluster for DACH1:

Dachshund homolog 1 (Drosophila)

Hs.129452 [show with all ESTs]

Unigene Representative Sequence: NM_080759

4 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000305425(uc021rkj.1) ENST00000359684 ENST00000313174(uc021rkk.1)

ENST00000354591(uc021rkl.1)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DACH1
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		hsa-miR-376b hsa-miR-300 hsa-miR-4305 hsa-miR-134 hsa-miR-374a hsa-miR-342-3p hsa-miR-508-5p hsa-miR-155*

		SwitchGear 3'UTR luciferase reporter plasmid: DACH1 3' UTR sequence

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DACH1

Additional cDNA sequence:

AF069509.1 AF102546.1 AF356492.1 AJ005670.1 AK001000.1 AL079278.1 BC021219.2

16 DOTS entries:

DT.111486 DT.100025625 DT.120782525 DT.120782470 DT.120782500 DT.92423852 DT.87046178 DT.95129743

DT.100695640 DT.100695642 DT.120933407 DT.121236364 DT.87018230 DT.95139642 DT.95223619 DT.97864380

1 AceView cDNA sequence:

R74591

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DACH1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAGGACCTAT

About this image

DACH1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

10/13 LifeMap In Vivo Development Anatomical Compartments/Cells (see all 13)

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Placenta

Chorioallantoic Placenta

Extraembryonic Angioblasts

Endothelium

Spinal Cord

Spinal Dorsal Columns

Dorsal Spinal Cord Progenitor Cells

Spinal Cord

Spinal Ventral Columns

Ventral Spinal Cord Progenitor Cells

Motor Neurons

Brain

Brain

Eye

Kidney

Lower Urinary Tract

Mesencephalic Ventricular Zone

Neural Tube

Metencephalon

Neural Tube

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 2 LifeMap Cells

Name

Category

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

Beating cell clusters (Spontaneous differen...)

See DACH1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DACH1

SOURCE GeneReport for Unigene cluster: Hs.129452

UniProtKB/Swiss-Prot: DACH1_HUMAN, Q9UI36

Tissue specificity: Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform

3 is found in liver and heart. Isoform 4 is found in spleen

SABiosciences Expression via Pathway-Focused PCR Array including DACH1:

Stem Cell Transcription Factors in human mouse rat

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for DACH1 gene from 6/17 species (see all 17) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DACH1¹	dachshund homolog 1 (Drosophila)	86.75(n) 93.58(a)		373935 NM_001199446.1 NP_001186375.1
lizard (Anolis carolinensis)	Reptilia	DACH1⁶	--	96(a)	1 ↔ 1	3(82543430-82912211)
African clawed frog (Xenopus laevis)	Amphibia	BJ063320.1²	--	81.52(n)		BJ063320.1
zebrafish (Danio rerio)	Actinopterygii	dachc²	dachshund c	75.75(n)		192123 AF427110.1
fruit fly (Drosophila melanogaster)	Insecta	dac⁶	dachshund	18(a)	1 → many	2L(16466512-16485984)
worm (Caenorhabditis elegans)	Secernentea	dac-1⁶	DAChsund transcription factor homolog family membe...	30(a)	1 → many	III(816240-821723)

ENSEMBL Gene Tree for DACH1 (if available)
TreeFam Gene Tree for DACH1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DACH1 gene

DACH2²

1 SIMAP similar gene for DACH1 using alignment to 3 protein entries: DACH1_HUMAN (see all proteins):

DACH2

DACH1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 13 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192524769^1,2	C,	unknown	53060771(+)	`AAAAGC/TGATGA`	3	--	int¹		0	--	--	--	--
rs17088237^1,2	C,F,H,	--	52713620(+)	`TACTTT/CGCATT`	3	--	ds500¹		8		NA NS EA WA	680
rs77617165^1,2		--	52713626(+)	`GCATTA/CTTCAG`	3	--	ds500¹		2		CSA WA	120
rs9805580^1,2	H	--	52713688(+)	`AAGGTA/CCAAAT`	3	--	ds500¹		4		NS EA	414
rs73213377^1,2	C,F,	--	52713833(+)	`TCACCA/GCAGTA`	3	--	ds500¹		1		NA	120
rs10507792^1,2	C,F,H,	--	52714013(+)	`AAAGTC/AACAGG`	3	--	ds500¹		15		NS NA EA	960
rs116798534^1,2	C,F,	--	52714172(+)	`ACAGAT/CTTTTG`	3	--	ut3¹		1		WA	118
rs111762831^1,2	C,	--	52715223(+)	`NNNNCG/AATCAT`	3	--	ut3¹		2		NA	122
rs11620294^1,2	C,F,H,	--	52715271(+)	`GTGACC/TGTACT`	3	--	ut3¹ ese³		5		NS EA NA	418
rs75101079^1,2	C,	--	52715272(+)	`TGACCG/ATACTG`	3	--	ut3¹		2		CSA WA	120

HapMap Linkage Disequilibrium report for DACH1 (72012098 - 72262098 bp, first 250kb of DACH1)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for DACH1
4 CNVs: 4811 101771 3912 29631
2 Indels: 45197 25293

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing DACH1

DNA2.0 Custom Variant and Variant Library Synthesis for DACH1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

DACH1 for disorders           About GeneDecksing

OMIM gene information: 603803    OMIM disorders: --

20/21 diseases for DACH1 (see all 21):    About MalaCards

postaxial polydactyly type a anophthalmia/microphthalmia malignant peripheral nerve sheath tumor clear cell renal cell carcinoma

anophthalmia branchiooculofacial syndrome polydactyly branchiootorenal syndrome

microphthalmia renal cell carcinoma reticulosarcoma endometritis

kidney disease gastric cancer prostate cancer breast cancer

carcinoma retinitis prostatitis neuronitis

GeneTests: DACH1

Anophthalmia/Microphthalmia

Human Genome Epidemiology (HuGE) Navigator: DACH1 (6 documents)

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(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DACH1 gene, integrated from 9 sources (see all 55):
(articles sorted by number of sources associating them with DACH1)

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The DNA sequence and analysis of human chromosome 13. (PubMed id 15057823)^{1, 2, 3} Dunham A.... Ross M.T. (2004)
DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. (PubMed id 14525983)^{1, 2, 9} Wu K.... Pestell R.G. (2003)
Dach: genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the mouse homolog. (PubMed id 11543628)^{1, 2, 9} Ayres J.A.... Nuckolls G.H. (2001)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Structure of the retinal determination protein dachshund reveals a DNA binding motif. (PubMed id 12057194)^{1, 2} Kim S.-S....Hegde R.S. (2002)
Localization of the human homologue of the Drosophila dachshund gene (DACH) to chromosome 13q21. (PubMed id 10395809)^{1, 3} Kozmik Z. and Cvekl A. (1999)
Molecular cloning and expression of the human and mouse homologues of the Drosophila dachshund gene. (PubMed id 10502110)^{1, 2} Kozmik Z....Cvekl A. (1999)
Human (DACH) and mouse (Dach) homologues of Drosophila dachshund map to chromosomes 13q22 and 14E3, respectively. (PubMed id 9933575)^{1, 3} Hammond K.L....Hanson I.M. (1999)
Mammalian and Drosophila dachshund genes are related to the Ski proto-oncogene and are expressed in eye and limb. (PubMed id 9651501)^{1, 2} Hammond K.L.... Hill R.E. (1998)
Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein. (PubMed id 12215533)^{1, 9} Ikeda K....Kawakami K. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1602	HGNC: 2663	AceView: DACH1.2	Ensembl:ENSG00000165659	euGenes: HUgn1602
ECgene: DACH1	H-InvDB: DACH1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for DACH1	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/DACH1

Intellectual Property for DACH1 gene
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Patent Information for DACH1 gene:
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dachshund homolog 1 (Drosophila)

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dachshund homolog 1 (Drosophila)

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