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Aliases for DACH1 Gene

Aliases for DACH1 Gene

  • Dachshund Family Transcription Factor 1 2 3
  • DACH 3 4 6
  • Dachshund Homolog 1 (Drosophila) 2
  • Dachshund Homolog (Drosophila) 2
  • Dachshund Homolog 1 3
  • Dac Homolog 3
  • Dach1 4

External Ids for DACH1 Gene

Previous Symbols for DACH1 Gene

  • DACH

Summaries for DACH1 Gene

Entrez Gene Summary for DACH1 Gene

  • This gene encodes a chromatin-associated protein that associates with other DNA-binding transcription factors to regulate gene expression and cell fate determination during development. The protein contains a Ski domain that is highly conserved from Drosophila to human. Expression of this gene is lost in some forms of metastatic cancer, and is correlated with poor prognosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

GeneCards Summary for DACH1 Gene

DACH1 (Dachshund Family Transcription Factor 1) is a Protein Coding gene. Diseases associated with DACH1 include postaxial polydactyly, type a2 and anophthalmia/microphthalmia. GO annotations related to this gene include nucleotide binding and RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly.

UniProtKB/Swiss-Prot for DACH1 Gene

  • Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).

Gene Wiki entry for DACH1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DACH1 Gene

Genomics for DACH1 Gene

Genomic Location for DACH1 Gene

Start:
71,437,966 bp from pter
End:
71,867,192 bp from pter
Size:
429,227 bases
Orientation:
Minus strand

Genomic View for DACH1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DACH1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DACH1 Gene

Regulatory Elements for DACH1 Gene

Proteins for DACH1 Gene

  • Protein details for DACH1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UI36-DACH1_HUMAN
    Recommended name:
    Dachshund homolog 1
    Protein Accession:
    Q9UI36
    Secondary Accessions:
    • D0FY35
    • D0FY36
    • O75523
    • O75687
    • Q5VYY3
    • Q5VYY4
    • Q96SG3
    • Q96SG4
    • Q9H524
    • Q9UMH4

    Protein attributes for DACH1 Gene

    Size:
    760 amino acids
    Molecular mass:
    78676 Da
    Quaternary structure:
    • Interacts with SIX1, SIX6 and EYA3. Interacts with NCOR1 and HDAC3 through its N-terminus. Interacts with SIN3A through its C-terminus (By similarity). Interacts with SMAD3 and SMAD4.
    SequenceCaution:
    • Sequence=CAA06666.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAC12840.2; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH73005.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH73006.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH73303.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAH73304.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14979.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI14980.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI16673.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DACH1 Gene

    Alternative splice isoforms for DACH1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DACH1 Gene

Proteomics data for DACH1 Gene at MOPED

Post-translational modifications for DACH1 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys653 and Lys668

Other Protein References for DACH1 Gene

No data available for DME Specific Peptides for DACH1 Gene

Domains for DACH1 Gene

Protein Domains for DACH1 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

DACH1_HUMAN
Domain:
  • The DACHbox-N/DD1 domain forms a structure containing a DNA binding motif similar to that of the forkhead/winged helix domain:
    • Q9UI36
Family:
  • Belongs to the DACH/dachshund family.:
    • Q9UI36
genes like me logo Genes that share domains with DACH1: view

No data available for Gene Families for DACH1 Gene

Function for DACH1 Gene

Molecular function for DACH1 Gene

UniProtKB/Swiss-Prot Function: Transcription factor that is involved in regulation of organogenesis. Seems to be a regulator of SIX1, SIX6 and probably SIX5. Corepression of precursor cell proliferation in myoblasts by SIX1 is switched to coactivation through recruitment of EYA3 to the SIX1-DACH1 complex. Transcriptional activation seems also to involve association of CREBBP. Seems to act as a corepressor of SIX6 in regulating proliferation by directly repressing cyclin-dependent kinase inhibitors, including the p27Kip1 promoter (By similarity). Inhibits TGF-beta signaling through interaction with SMAD4 and NCOR1. Binds to chromatin DNA via its DACHbox-N domain (By similarity).

Gene Ontology (GO) - Molecular Function for DACH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001075 RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly IEA --
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription IDA 20956529
GO:0003677 DNA binding IEA --
GO:0003700 sequence-specific DNA binding transcription factor activity --
GO:0005515 protein binding IPI 14525983
genes like me logo Genes that share ontologies with DACH1: view
genes like me logo Genes that share phenotypes with DACH1: view

Animal Models for DACH1 Gene

MGI Knock Outs for DACH1:

miRNA for DACH1 Gene

miRTarBase miRNAs that target DACH1

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for DACH1 Gene

Localization for DACH1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DACH1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DACH1 Gene COMPARTMENTS Subcellular localization image for DACH1 gene
Compartment Confidence
nucleus 5
cytosol 2
endoplasmic reticulum 1
extracellular 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for DACH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IDA --
GO:0005654 nucleoplasm IDA --
GO:0005667 transcription factor complex IEA --
GO:0005730 nucleolus IDA --
GO:0005737 cytoplasm IEA --
genes like me logo Genes that share ontologies with DACH1: view

Pathways for DACH1 Gene

SuperPathways for DACH1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for DACH1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000122 negative regulation of transcription from RNA polymerase II promoter IEA --
GO:0001967 suckling behavior IEA --
GO:0006355 regulation of transcription, DNA-templated --
GO:0007585 respiratory gaseous exchange IEA --
GO:0008283 cell proliferation IEA --
genes like me logo Genes that share ontologies with DACH1: view

No data available for Pathways by source for DACH1 Gene

Transcripts for DACH1 Gene

mRNA/cDNA for DACH1 Gene

(7) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(4) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for DACH1 Gene

Dachshund homolog 1 (Drosophila):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DACH1 Gene

No ASD Table

Relevant External Links for DACH1 Gene

GeneLoc Exon Structure for
DACH1
ECgene alternative splicing isoforms for
DACH1

Expression for DACH1 Gene

mRNA expression in normal human tissues for DACH1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DACH1 Gene

This gene is overexpressed in Brain - Caudate (basal ganglia) (5.5) and Brain - Putamen (basal ganglia) (5.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DACH1 Gene

SOURCE GeneReport for Unigene cluster for DACH1 Gene Hs.129452

mRNA Expression by UniProt/SwissProt for DACH1 Gene

Q9UI36-DACH1_HUMAN
Tissue specificity: Widely expressed. Isoform 2 is found in brain, heart, kidney, liver, leukocytes and spleen. Isoform 3 is found in liver and heart. Isoform 4 is found in spleen.
genes like me logo Genes that share expressions with DACH1: view

Orthologs for DACH1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for DACH1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DACH1 36
  • 99.11 (n)
  • 98.87 (a)
cow
(Bos Taurus)
Mammalia DACH1 36
  • 94.92 (n)
  • 100 (a)
dog
(Canis familiaris)
Mammalia DACH1 36
  • 94.36 (n)
  • 99.5 (a)
mouse
(Mus musculus)
Mammalia Dach1 36
  • 90.76 (n)
  • 95.55 (a)
Dach1 16
rat
(Rattus norvegicus)
Mammalia Dach1 36
  • 88.23 (n)
  • 93.53 (a)
chicken
(Gallus gallus)
Aves DACH1 36
  • 88.77 (n)
  • 98.16 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia dach1 36
  • 82.16 (n)
  • 91.43 (a)
zebrafish
(Danio rerio)
Actinopterygii dachc 36
dachd 36
  • 77.88 (n)
  • 88.85 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.2640 36
Species with no ortholog for DACH1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for DACH1 Gene

ENSEMBL:
Gene Tree for DACH1 (if available)
TreeFam:
Gene Tree for DACH1 (if available)

Paralogs for DACH1 Gene

Selected SIMAP similar genes for DACH1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with DACH1: view

No data available for Paralogs for DACH1 Gene

Variants for DACH1 Gene

Sequence variations from dbSNP and Humsavar for DACH1 Gene

SNP ID Clin Chr 13 pos Sequence Context AA Info Type MAF
rs93177 -- 71,790,579(-) CTAGA(A/G/T)TTTTG intron-variant
rs167341 -- 71,816,622(+) cacgt(A/G)tatat intron-variant
rs191009 -- 71,782,290(+) acaaa(A/C)aatta intron-variant
rs215914 -- 71,782,152(+) ATAAA(A/T)GTTTG intron-variant
rs303929 -- 71,806,714(+) TATTA(C/G)TCTAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DACH1 Gene

Variant ID Type Subtype PubMed ID
nsv471153 CNV Loss 18288195
dgv361e199 CNV Deletion 23128226
nsv900524 CNV Loss 21882294
dgv1685n71 CNV Gain+Loss 21882294
nsv900526 CNV Loss 21882294
nsv900527 CNV Gain 21882294
nsv900528 CNV Loss 21882294
nsv832645 CNV Gain 17160897
dgv1686n71 CNV Loss 21882294
dgv1687n71 CNV Loss 21882294
nsv471154 CNV Gain 18288195
dgv1688n71 CNV Loss 21882294
esv2747602 CNV Deletion 23290073
nsv900537 CNV Loss 21882294
nsv900539 CNV Gain 21882294
nsv455981 CNV Loss 19166990
esv2747603 CNV Deletion 23290073
dgv256e201 CNV Deletion 23290073
esv2747605 CNV Deletion 23290073
dgv257e201 CNV Deletion 23290073
esv2747609 CNV Deletion 23290073
nsv455984 CNV Loss 19166990
nsv510612 CNV Loss 20534489
nsv900547 CNV Loss 21882294
nsv900548 CNV Loss 21882294
esv2747611 CNV Deletion 23290073
esv1703652 CNV Deletion 17803354
dgv258e201 CNV Deletion 23290073
dgv259e201 CNV Deletion 23290073
esv2747616 CNV Deletion 23290073
esv2399056 CNV Deletion 18987734
nsv64658 CNV Loss 16902084
esv2747617 CNV Deletion 23290073
esv2747618 CNV Deletion 23290073
esv1592042 CNV Deletion 17803354
nsv510350 CNV Loss 20534489
dgv571e1 CNV Complex 17122850
esv2747620 CNV Deletion 23290073
esv2747621 CNV Deletion 23290073
esv272653 CNV Insertion 20981092
esv2441342 CNV Deletion 19546169
esv2747622 CNV Deletion 23290073
esv2747623 CNV Deletion 23290073
esv1005359 CNV Deletion 20482838
esv1241719 CNV Deletion 17803354
esv2747624 CNV Deletion 23290073
nsv1081 CNV Loss 18451855

Relevant External Links for DACH1 Gene

HapMap Linkage Disequilibrium report
DACH1
Human Gene Mutation Database (HGMD)
DACH1

Disorders for DACH1 Gene

Relevant External Links for DACH1

GeneTests
DACH1
GeneReviews
DACH1
Genetic Association Database (GAD)
DACH1
Human Genome Epidemiology (HuGE) Navigator
DACH1
genes like me logo Genes that share disorders with DACH1: view

No data available for UniProtKB/Swiss-Prot for DACH1 Gene

Publications for DACH1 Gene

  1. Dach: genomic characterization, evaluation as a candidate for postaxial polydactyly type A2, and developmental expression pattern of the mouse homolog. (PMID: 11543628) Ayres J.A. … Nuckolls G.H. (Genomics 2001) 3 4 23
  2. DACH1 inhibits transforming growth factor-beta signaling through binding Smad4. (PMID: 14525983) Wu K. … Pestell R.G. (J. Biol. Chem. 2003) 3 4 23
  3. The DNA sequence and analysis of human chromosome 13. (PMID: 15057823) Dunham A. … Ross M.T. (Nature 2004) 2 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis. (PMID: 19901965) Miller S.J. … Ratner N. (Oncogene 2010) 3 23

Products for DACH1 Gene

Sources for DACH1 Gene

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