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DAB2IP Gene

protein-coding GIFtS: 59

GC09P123368

DAB2 interacting protein
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
AF9Q34 ^¹, ², ³
AIP1 ^¹, ², ³
DIP1/2 ^¹, ²
FLJ39072 ^²
KIAA1743 ^¹, ², ³
OTTHUMP00000022026 ^²
OTTHUMP00000022028 ^²

Descriptions
ASK-interacting protein ^²
ASK-interacting protein 1 ^³
ASK1-interacting protein 1 ^²
DAB2 interacting protein ^²
DAB2 interaction protein ^³
DAB2-interacting protein ^³
DOC-2/DAB2 interactive protein ^²
disabled homolog 2 interacting protein ^²
nGAP-like protein ^²

External Ids
HGNC: 17294¹
Entrez Gene: 153090²
UniProtKB: Q5VWQ8³
Ensembl: ENSG00000136848⁷

Search outside databases for aliases for DAB2IP gene

Previous GC identifers: GC09P115566 GC09P115975 GC09P117783 GC09P119837 GC09P121541

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for DAB2IP:

DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene

and is inactivated by methylation in prostate and breast cancers (Yano et al., 2005 [PubMed

15386433]).[supplied by OMIM]

UniProtKB/Swiss-Prot: DAB2P_HUMAN, Q5VWQ8

Function: Functions as a Ras GTPase-activating protein (By similarity). Through its interaction

with MAP3K5 disrupts the association of MAP3K5 with the inhibitory 14-3-3 complex. Mediates

TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. May act as a

tumor suppressor gene

Gene Wiki entry for DAB2IP

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DAB2IP gene

Entrez Gene cytogenetic band: 9q33.1-q33.3 Ensembl cytogenetic band: 9q33.2 HGNC cytogenetic band: 9q33.1-q33.3

DAB2IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09P123368: (about GC identifiers)

Start:	123,368,983 bp from pter
End:	123,587,630 bp from pter
Size:	218,648 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000009.10 NT_008470.18

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DAB2P_HUMAN, Q5VWQ8 (See protein sequence)

Recommended Name: Disabled homolog 2-interacting protein

Size: 1189 amino acids; 131625 Da

Subunit: Interacts with MAP3K5, preferentially with its 'Ser-966' dephosphorylated form. On plasma

membrane, exists in an inactive form complexed with TNFR1. In response to TNF, dissociates from

TNFR1 complex, tranlocates to cytoplasm and forms part of an intracellular signaling complex

comprising TRADD, RALBP1, TRAF2 and MAP3K5. Binding to MAP3K5 is induced by TNF. Interacts with

DAB1 and DAB2 (By similarity)

Subcellular location: Membrane. Cytoplasm. Note=Translocates to the cytoplasm in response to TNF

Sequence caution: Sequence=CAH72155.3; Type=Erroneous gene model prediction;

Secondary accessions: A6H8V2 A6NHI9 B0QZB1 Q8TDL2 Q96SE1 Q9C0C0

Alternative splicing: 4 isoforms: Q5VWQ8-1 Q5VWQ8-2 Q5VWQ8-3 Q5VWQ8-4

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (2 alternative transcripts):

NP_115941.2 NP_619723.1

ENSEMBL proteins:

ENSP00000259371 ENSP00000310827 ENSP00000377872 ENSP00000362887 ENSP00000362890 ENSP00000386183

ENSP00000362892

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DAB2IP)
	Human Recombinant Proteins from Abnova (DAB2IP)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	IEA	--
GO:0005737	cytoplasm	IEA	--
GO:0016020	membrane	IEA	--

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Antibodies for DAB2IP:

	Invitrogen Antibodies for DAB2IP
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Browse Antibodies at Sigma-Aldrich
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (DAB2IP), each with their Abpromise^SM
	Browse Abnova for Monoclonal and Polyclonal Antibodies
	Search Novus for antibodies for DAB2IP

Assays for DAB2IP:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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Graphical View of Domain Structure for InterPro Entry Q5VWQ8

ProtoNet protein and cluster: Q5VWQ8

2 Blocks protein families:

IPB000008 C2 domain

IPB001936 Ras GTPase-activating protein

UniProtKB/Swiss-Prot: DAB2P_HUMAN, Q5VWQ8

Domain: The C2 and Ras-GAP domains are required for the interaction with MAP3K5

Similarity: Contains 1 C2 domain

Similarity: Contains 1 PH domain

Similarity: Contains 1 Ras-GAP domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAB2IP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_138709

Applied Biosystems Silencer® siRNAs for DAB2IP

Sigma-Aldrich siRNA and siRNA Panels for DAB2IP

Sigma-Aldrich shRNA for DAB2IP

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_032552
Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_032552
untagged cDNA clones in CMV expression vector (see all 3): NM_032552

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_032552

UniProtKB/Swiss-Prot: DAB2P_HUMAN, Q5VWQ8

Function: Functions as a Ras GTPase-activating protein (By similarity). Through its interaction

with MAP3K5 disrupts the association of MAP3K5 with the inhibitory 14-3-3 complex. Mediates

TNF/TRAF2-induced MAP3K5-JNK activation, while it inhibits CHUK-NF-kappa-B signaling. May act as a

tumor suppressor gene

3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dab2ip):

cellular

homeostasis/metabolism

no phenotypic analysis

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005096	GTPase activator activity	IEA	--

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Gene Network Central^TM Interacting Genes and Proteins Network for DAB2IP

5 Interacting proteins for DAB2IP (Q5VWQ8² ENSP00000362887³) via UniProtKB, MINT, and/or STRING

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP3K5	Q99683², ENSP00000351908³	MINT-18458 MINT-18459 STRING (score=.941)
DAB2	ENSP00000313391³	STRING (score=.958)
KRR1	ENSP00000229214³	STRING (score=.873)
RASD1	ENSP00000225688³	STRING (score=.792)
TRADD	ENSP00000341268³	STRING (score=.784)

About this table

3 Gene Ontology (GO) biological process terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007165	signal transduction	IEA	--
GO:0045786	negative regulation of cell cycle	IEA	--
GO:0051056	regulation of small GTPase mediated signal transduction	IEA	--

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DAB2IP

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAB2IP)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 2): NM_138709

Sigma-Aldrich siRNA and siRNA Panels for DAB2IP

Sigma-Aldrich shRNA for DAB2IP

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_032552 NM_138709

REFSEQ mRNAs for DAB2IP gene (2 alternative transcripts):

NM_032552.2 NM_138709.1

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_032552 NM_138709

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 2): NM_032552
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 2): NM_032552
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_032552

Additional cDNA sequence:

AB051530.2 AF367051.1 AK054851.1 AK096378.1 AK096391.1 AK124609.1 AK124610.1 AY032952.1

BC011496.1 BC037314.2 BC040911.1 BC127781.1 BC146762.1 CR606128.1

10 DOTS entries:

DT.455156 DT.97806367 DT.91721840 DT.97801048 DT.92427774 DT.435196 DT.426257 DT.121156960

DT.121627968 DT.92427773

24/273 AceView cDNA sequences (see all 273 ):

T31831 BM719243 BF869213 BU732818 BM811555 CA430652 BM976219 AI627407

BU729692 BM694368 AI362708 BE463433 BU622674 BQ719987 BU855537 BC040911

AK096378 Z39481 BI490397 BQ021388 BX488182 CA432773 BM704390 BM683195

highest scoring ESTs for DAB2IP:

AA059396 AA099547 AA133785 AA133786 AA135871 AA137176 AA436997 AA464784 AA488171 AA488225

Unigene Cluster for DAB2IP:

DAB2 interacting protein

Hs.522378 [show with all ESTs]

Unigene Representative Sequence: NM_032552

GeneLoc Exon Structure

5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DAB2IP (see all 10 )

ExUns:	1	^	2	^	3	^	4	^	5	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14	^	15	^	16	^	17a	·	17b	^	18a	·	18b	^	19a	·	19b	^	20a	·
SP1:
SP2:					-		-		-
SP3:																																											-				-
SP4:			-		-		-		-
SP5:

ExUns:	20b	·	20c	^	21a	·	21b
SP1:
SP2:
SP3:	-		-
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for DAB2IP

7 Ensembl transcripts including schematic representations:

ENST00000259371 ENST00000309989 ENST00000394340 ENST00000373782 ENST00000373785 ENST00000408936

ENST00000373787

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

DAB2IP expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DAB2IP

¹ / ² / ³

9 probe-sets matching DAB2IP gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
45741_at²^{, 3}	U95-B	1	1.00	1.00	0.92	1.26	AA059396	1.00	1.00	1.00	1
91760_at²^{, 3}	U95-E	1	1.00	1.00	0.68	1.38	AI761274	0.60	1.00	0.82	1
45742_g_at²^{, 3}	U95-B	1	1.00	1.00	0.87	1.38	AA059396	1.00	1.00	1.00	1
51735_s_at²^{, 3}	U95-C	1	1.00	1.00	0.70	0.36	AI971922	0.80	1.00	0.91	1
72473_at²^{, 3}	U95-D	1	1.00	1.00	0.22	0.65	AA709010	0.80	1.00	0.91	1
228942_s_at²^{, 3}	U133-B	1	1.00	1.00	--	--	BE858624	0.60	1.00	0.82	1
225020_at²^{, 3}	U133-B	2	1.00	0.95	--	--	AB051530	0.80	1.00	0.91	1
228942_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
225020_at²	U133Plus2	2	1.00	0.95	--	--	--	--	--	--	--

About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: TTCTGGGTGA

SOURCE GeneReport for Unigene cluster: Hs.522378
UniProtKB/Swiss-Prot: DAB2P_HUMAN, Q5VWQ8
Tissue specificity: Low expression in prostate. Down-regulated in prostate cancer

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DAB2IP gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DAB2IP¹	--	DAB2 interacting protein	89.87(n) 95.26(a)	491356 XM_548477.2 XP_548477.2
cow (Bos taurus)	DAB2IP¹	--	DAB2 interacting protein	90.59(n) 96.87(a)	541268 XM_615396.3 XP_615396.3
rat (Rattus norvegicus)	Dab2ip¹	--	DAB2 interacting protein	90.15(n) 97.41(a)	192126 NM_138710.1 NP_619724.1
mouse (Mus musculus)	Dab2ip^{1, 5}	2⁵	disabled homolog 2 (Drosophila) interacting protein^{1, 5}	89.66(n)¹ 97.51(a)¹	69601¹ NM_001001602.1¹ NP_001001602.1¹ AI480459⁵ AK009291⁵ (see all 22)
chicken (Gallus gallus)	DAB2IP¹	--	DAB2 interacting protein	78.79(n) 84.12(a)	417117 XM_415400.2 XP_415400.2

About this table Species with no ortholog for DAB2IP

ENSEMBL Gene Tree for DAB2IP

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

Paralogs for DAB2IP gene

SYNGAP1² RASAL2²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/959 NCBI SNPs in DAB2IP are shown (see all 959 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 89)

AB	SNP ID	Valid	Chr 9 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs1768730^1,2	A,C,F,H	123368354(-)	`AGCAAA/GTGATG`	1	--	ng5¹		4		EU EA WA	414
	rs10985372^1,2	C,F,H	123585964(+)	`CTCTCG/AGCCCC`	1	--	ut3¹ ese³		4		EU EA WA	418
	rs11791478^1,2	C,F,H	123588062(+)	`TGGGCC/GCAGGT`	1	--	ng3¹		6		EU EA WA NA	600
--	rs7042758^1,2	C,F,H	123368015(+)	`taaaaT/Caggag`	1	--	ng5¹		4		EU EA WA	408
--	rs7027492^1,2	F,H	123480829(+)	`CCTTTC/TCGAGA`	1	S/F	mis¹		4		EU EA WA	418
--	rs7042542^1,2	F,H	123367869(+)	`ATTGAT/GTGAGA`	1	--	ng5¹ tfbs³		4		EU EA WA	416
	rs12002566^1,2	H	123587415(+)	`CCCAGC/TTCCCA`	1	--	ut3¹ ese³		4		EU EA WA	416
--	rs10217679^1,2	C	123544499(+)	`actccA/Ggcctg`	2	--	int¹ ng5¹		0	--	--	--	--
--	rs10117555^1,2	C	123368342(+)	`TCACCA/GGCCTC`	1	--	ng5¹		0	--	--	--	--
	rs34458419^1,2	F	123575074(+)	`AGGGCG/ACGCCA`	2	T/A	mis¹		1		NA	74

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HapMap Linkage Disequilibrium images for DAB2IP (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 609205

UniProtKB/Swiss-Prot: DAB2P_HUMAN, Q5VWQ8

A chromosomal aberration involving DAB2IP is found in a patient with acute myeloid

leukemia (AML). Translocation t(9;11)(q34;q23) with MLL. May give rise to a MLL-DAB2IP fusion

protein lacking the PH domain

3 Novoseek disease relationships for DAB2IP gene

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
prostate cancer	33.70	6	11944990 (3), 16629596 (1), 15817459 (1)
necrosis	18.90	4	17389591 (2), 15817459 (1), 18292600 (1)
tumors	0.00	4	17389591 (2), 15817459 (1), 18292600 (1)

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Human Genome Epidemiology Navigator: DAB2IP (3 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/25 PubMed articles for DAB2IP gene (see all 25 ):

Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization. (PubMed id 11944990)^{1, 2, 3, 4} Chen H.... Hsieh J.-T. (2002)
AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3. (PubMed id 12813029)^{1, 3, 4} Zhang R.... Min W. (2003)
AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2- induced ASK1-JNK activation. (PubMed id 15310755)^{1, 3, 4} Zhang H.... Min W. (2004)
Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia. (PubMed id 14978793)^{1, 3, 4} von Bergh A.R.M.... Schuuring E. (2004)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)^{3, 4} Humphray S.J.... Dunham I. (2004)
The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. (PubMed id 11812785)^{2, 3} Wang Z....Hsieh J.T. (2002)
Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)^{3, 4} Nakajima D.... Nagase T. (2002)
Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)^{3, 4} Nagase T....Ohara O. (2000)
Down-regulation of human DAB2IP gene expression mediated by polycomb Ezh2 complex and histone deacetylase in prostate cancer. (PubMed id 15817459)^{1, 3} Chen H....Hsieh J.T. (2005)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 153090	HGNC: 17294	AceView: DAB2IP	Ensembl:ENSG00000136848	euGenes: HUgn153090
ECgene: DAB2IP	H-InvDB: DAB2IP

(According to HUGE)
About This Section

HUGE: KIAA1743

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for DAB2IP	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for DAB2IP
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for DAB2IP:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DAB2IP-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DAB2IP		Browse antibodies at Sigma-Aldrich
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DAB2IP		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

	Antibodies		Primer Pairs
	Cell Culture Products		ELISAs
	Flow Cytometry Kits		Protease Activity Assays & Reagents
	Cell Selection/Detection Kits & Reagents		ELISA/Assay Development Kits & Reagents
	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
	Recombinant & Natural Proteins

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DAB2IP Gene

protein-coding GIFtS: 59

Aliases &
Descriptions
for DAB2IP

Summaries
for DAB2IP

Genomic Location
for DAB2IP

Proteins
for DAB2IP

Protein Domains/
Families
for DAB2IP

Gene Function
for DAB2IP

Pathways & Interactions
for DAB2IP

Drugs & Compounds
for DAB2IP

Transcripts
for DAB2IP

Expression
for DAB2IP

Orthologs
for DAB2IP

Paralogs
for DAB2IP

SNPs/Variants
for DAB2IP

Disorders & Mutations
for DAB2IP

Medical News
for DAB2IP

Publications
for DAB2IP

Search for DAB2IP

Genome Databases showing DAB2IP

Other Databases showing DAB2IP

Specialized Databases showing DAB2IP

Licensable Technologies
for DAB2IP

Services
for DAB2IP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DAB2IP Gene

protein-coding GIFtS: 59

Aliases & Descriptionsfor DAB2IP

Summariesfor DAB2IP

Genomic Locationfor DAB2IP

Proteinsfor DAB2IP

Protein Domains/Familiesfor DAB2IP

Gene Functionfor DAB2IP

Pathways & Interactionsfor DAB2IP

Drugs & Compoundsfor DAB2IP

Transcriptsfor DAB2IP

Expression for DAB2IP

Orthologsfor DAB2IP

Paralogsfor DAB2IP

SNPs/Variantsfor DAB2IP

Disorders & Mutationsfor DAB2IP

Medical Newsfor DAB2IP

Publicationsfor DAB2IP

Search for DAB2IP

Genome Databases showing DAB2IP

Other Databases showing DAB2IP

Specialized Databases showing DAB2IP

Licensable Technologiesfor DAB2IP

Servicesfor DAB2IP

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DAB2IP

Summaries
for DAB2IP

Genomic Location
for DAB2IP

Proteins
for DAB2IP

Protein Domains/
Families
for DAB2IP

Gene Function
for DAB2IP

Pathways & Interactions
for DAB2IP

Drugs & Compounds
for DAB2IP

Transcripts
for DAB2IP

Expression
for DAB2IP

Orthologs
for DAB2IP

Paralogs
for DAB2IP

SNPs/Variants
for DAB2IP

Disorders & Mutations
for DAB2IP

Medical News
for DAB2IP

Publications
for DAB2IP

Licensable Technologies
for DAB2IP

Services
for DAB2IP