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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAB2IP Gene

protein-coding   GIFtS: 57
GCID: GC09P124329

DAB2 interacting protein
 Explore 11 diseases affiliated with
DAB2IP via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for DAB2IP    

Aliases
for DAB2IP gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
DAB2 Interacting Protein1 2     DAB2 Interaction Protein2 3
AIP11 2 3 5     DAB2-Interacting Protein2 3
AF9Q341 2 3     ASK1-Interacting Protein 12
KIAA17431 3 5     Disabled Homolog 2-Interacting Protein2
DIP1/21 2     DOC-2/DAB2 Interactive Protein2
ASK-Interacting Protein 12 3     NGAP-Like Protein2

External Ids:    HGNC: 172941   Entrez Gene: 1530902   Ensembl: ENSG000001368487   OMIM: 6092055   UniProtKB: Q5VWQ83   

Export aliases for DAB2IP gene to outside databases

Previous GC identifers: GC09P115566 GC09P115975 GC09P117783 GC09P119837 GC09P121541 GC09P123368 GC09P093947


Summaries
for DAB2IP gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DAB2IP:
DAB2IP is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor. The DAB2IP gene is
inactivated by methylation in prostate and breast cancers (Yano et al., 2005 (PubMed 15386433)).(supplied by OMIM, May
2010)

UniProtKB/Swiss-Prot: DAB2P_HUMAN, Q5VWQ8
Function: Functions as a Ras GTPase-activating protein (By similarity). Through its interaction with MAP3K5 disrupts
the association of MAP3K5 with the inhibitory 14-3-3 complex. Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while
it inhibits CHUK-NF-kappa-B signaling. May act as a tumor suppressor gene

Gene Wiki entry for DAB2IP


Genomic Views
for DAB2IP gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAB2IP gene promoter:
         RFX1   MAZR   p53   NF-AT   NF-AT4   NF-AT2   NF-AT3   NF-AT1   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DAB2IP promoter sequence
   Search SABiosciences Chromatin IP Primers for DAB2IP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAB2IP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q33.1-q33.3   Ensembl cytogenetic band:  9q33.2   HGNC cytogenetic band: 9q33.1-q33.3

DAB2IP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAB2IP gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09P124329:  view genomic region     (about GC identifiers)

Start:
 124,329,336 bp from pter      End:
 124,547,809 bp from pter
Size:
 218,474 bases      Orientation:
 plus strand

Proteins
for DAB2IP gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DAB2P_HUMAN, Q5VWQ8 (See protein sequence)
Recommended Name: Disabled homolog 2-interacting protein  
Size: 1189 amino acids; 131625 Da
Subunit: Interacts with MAP3K5, preferentially with its 'Ser-966' dephosphorylated form. On plasma membrane, exists in
an inactive form complexed with TNFR1. In response to TNF, dissociates from TNFR1 complex, tranlocates to cytoplasm
and forms part of an intracellular signaling complex comprising TRADD, RALBP1, TRAF2 and MAP3K5. Binding to MAP3K5 is
induced by TNF. Interacts with DAB1 and DAB2 (By similarity). Part of a cytoplasmic complex made of HIPK1, DAB2IP and
MAP3K5 in response to TNF. This complex formation promotes MAP3K5-JNK activation and subsequent apoptosis
Subcellular location: Membrane. Cytoplasm. Note=Translocates to the cytoplasm in response to TNF
Sequence caution: Sequence=CAH72155.3; Type=Erroneous gene model prediction;
Secondary accessions: A6H8V2 A6NHI9 B0QZB1 Q8TDL2 Q96SE1 Q9C0C0
Alternative splicing: 4 isoforms:  Q5VWQ8-1   Q5VWQ8-2   Q5VWQ8-3   Q5VWQ8-4   (Gene prediction based on EST data)

Explore the universe of human proteins at neXtProt for DAB2IP: NX_Q5VWQ8

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q5VWQ8

    • DAB2IP Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_115941.2  NP_619723.1  

    ENSEMBL proteins: 
     ENSP00000377872   ENSP00000409327   ENSP00000386183   ENSP00000362887   ENSP00000310827  
     ENSP00000259371  

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    Novus Biologicals DAB2IP Protein
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    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DAB2IP

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005622intracellular ----
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA15310755
    GO:0031235intrinsic to internal side of plasma membrane IBA--


    DAB2IP for ontologies           About GeneDecksing



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    Uscn Antibodies for DAB2IP
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    Uscn ELISAs and CLIAs for DAB2IP

    Protein Domains /
    Families
    for DAB2IP gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DAB2IP for domains           About GeneDecksing

    5/8 InterPro domains/families (see all 8):
     IPR001936 RasGAP
     IPR008936 Rho_GTPase_activation_prot
     IPR001849 Pleckstrin_homology
     IPR011993 PH_like_dom
     IPR023152 RasGAP_CS

    Graphical View of Domain Structure for InterPro Entry Q5VWQ8

    ProtoNet protein and cluster: Q5VWQ8

    2 Blocks protein families:
    IPB000008 C2 domain
    IPB001936 Ras GTPase-activating protein


    UniProtKB/Swiss-Prot: DAB2P_HUMAN, Q5VWQ8
    Domain: The C2 and Ras-GAP domains are required for the interaction with MAP3K5
    Similarity: Contains 1 C2 domain
    Similarity: Contains 1 PH domain
    Similarity: Contains 1 Ras-GAP domain


    Function
    for DAB2IP gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DAB2P_HUMAN, Q5VWQ8
    Function: Functions as a Ras GTPase-activating protein (By similarity). Through its interaction with MAP3K5 disrupts
    the association of MAP3K5 with the inhibitory 14-3-3 complex. Mediates TNF/TRAF2-induced MAP3K5-JNK activation, while
    it inhibits CHUK-NF-kappa-B signaling. May act as a tumor suppressor gene

    miRNA
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    hsa-mir-338-3p (MIRT003041)

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    8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate DAB2IP (see all 71):
    hsa-miR-323-3p hsa-miR-574-3p hsa-miR-138-2* hsa-miR-149 hsa-miR-4325 hsa-miR-556-3p hsa-miR-376c hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: DAB2IP 3' UTR sequence
    Inhib. RNA
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    OriGene shRNA RFP: DAB2IP
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAB2IP

    Gene Editing
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    Clone
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    In Situ Assay
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    Gene Ontology (GO): 5/11 molecular function terms (GO ID links to tree view) (see all 11):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005099Ras GTPase activator activity ISS--
    GO:0005123death receptor binding IPI15310755
    GO:0005515protein binding ----
    GO:0005543phospholipid binding IEA--
    GO:0019901protein kinase binding IPI--


    DAB2IP for ontologies           About GeneDecksing


    1 GenomeRNAi human phenotype for DAB2IP:
     Increased viability after born 

    Animal Models:
         Mouse knock-out Dab2iptm1.1Wami for DAB2IP
         3 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Dab2ip):
     cellular  homeostasis/metabolism  no phenotypic analysis 

    DAB2IP for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DAB2IP gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAB2IP

    STRING Interaction Network Preview (showing 5 interactants - click image to see 9)

    5/16 Interacting proteins for DAB2IP (Q5VWQ82, 3 ENSP000002593714) via UniProtKB, MINT, STRING, and/or I2D (see all 16)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP3K5Q996832, 3, ENSP000003519084MINT-18458 MINT-18459 I2D: score=3 STRING: ENSP00000351908
    DAB1O755533, ENSP000003602774I2D: score=2 STRING: ENSP00000360277
    DAB2P980823, ENSP000003133914I2D: score=1 STRING: ENSP00000313391
    TP53P046373, ENSP000002693054I2D: score=1 STRING: ENSP00000269305
    TP63Q9H3D43, ENSP000002647314I2D: score=1 STRING: ENSP00000264731
    About this table

    Gene Ontology (GO): 5/25 biological process terms (GO ID links to tree view) (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000122negative regulation of transcription from RNA polymerase II promoter IMP--
    GO:0007257activation of JUN kinase activity IDA12813029
    GO:0009967positive regulation of signal transduction ----
    GO:0010633negative regulation of epithelial cell migration TAS--
    GO:0010719negative regulation of epithelial to mesenchymal transition IMP--


    DAB2IP for ontologies           About GeneDecksing



    Drugs & Compounds
    for DAB2IP gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DAB2IP
    Search CenterWatch for drugs/clinical trials and news about DAB2IP / DAB2P 

    Transcripts
    for DAB2IP gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DAB2IP gene (2 alternative transcripts): 
    NM_032552.2  NM_138709.1  

    Unigene Cluster for DAB2IP:

    DAB2 interacting protein
    Hs.522378  [show with all ESTs]
    Unigene Representative Sequence: NM_032552
    10 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000394340 ENST00000436835 ENST00000489314 ENST00000408936(uc004blp.3)
    ENST00000465078 ENST00000373782 ENST00000309989(uc004blo.3) ENST00000487716
    ENST00000459906 ENST00000259371(uc004bln.3)

    miRNA
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    8/71 QIAGEN miScript miRNA Assays for microRNAs that regulate DAB2IP (see all 71):
    hsa-miR-323-3p hsa-miR-574-3p hsa-miR-138-2* hsa-miR-149 hsa-miR-4325 hsa-miR-556-3p hsa-miR-376c hsa-miR-92b
    SwitchGear 3'UTR luciferase reporter plasmid: DAB2IP 3' UTR sequence
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAB2IP (see all 7)
    OriGene shRNA RFP: DAB2IP
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAB2IP
    Clone
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAB2IP
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAB2IP

    Additional cDNA sequence: 

    AB051530.2 AF367051.1 AK054851.1 AK096378.1 AK096391.1 AK124609.1 AK124610.1 AY032952.1 
    BC011496.1 BC037314.2 BC040911.1 BC127781.1 BC146762.1 

    11 DOTS entries:

    DT.455156  DT.97806367  DT.91721840  DT.92427774  DT.97801048  DT.435196  DT.92427773  DT.121156960 
    DT.121627968  DT.426257  DT.92427760 

    24/273 AceView cDNA sequences (see all 273):

    BG099262 BU181593 AI362708 AK096378 BE463433 BC040911 BI490397 Z39481 
    BU622674 BU732818 BF869213 AA938012 AK054851 AI351348 AI890959 AW295635 
    AB051530 AA019653 BM014426 AK124609 BX097591 R36219 BM694368 BM809114 

    GeneLoc Exon Structure

    5/10 Alternative Splicing Database (ASD) splice patterns (SP) for DAB2IP (see all 10)    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17a · 17b ^ 18a · 18b ^ 19a · 19b ^ 20a ·
    SP1:                                                                                                                                                            
    SP2:              -     -     -                                                                                                                                 
    SP3:                                                                                                                                -           -               
    SP4:        -     -     -     -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 20b · 20c ^ 21a · 21b
    SP1:                        
    SP2:                        
    SP3:  -     -               
    SP4:                        
    SP5:                        


    ECgene alternative splicing isoforms for DAB2IP

    Expression
    for DAB2IP gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAB2IP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TTCTGGGTGA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DAB2IP expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    2 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    BrainCerebral CortexBrain
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See DAB2IP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAB2IP

    SOURCE GeneReport for Unigene cluster: Hs.522378

    UniProtKB/Swiss-Prot: DAB2P_HUMAN, Q5VWQ8
    Tissue specificity: Low expression in prostate. Down-regulated in prostate cancer

        SABiosciences Expression via Pathway-Focused PCR Arrays including DAB2IP: 
              Prostate Cancer in human mouse rat
              Liver Cancer in human mouse rat

    Primer
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    In Situ
    Assay Products:     
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    Orthologs
    for DAB2IP gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DAB2IP gene from 6/21 species (see all 21)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves DAB2IP1 DAB2 interacting protein 78.79(n)
    84.12(a)    		   417117  XM_415400.3  XP_415400.3 
    lizard
    (Anolis carolinensis)    		 Reptilia DAB2IP6
    		 --
    		 74(a)
    		 1 ↔ 1
    		 AAWZ02036756(507-13081)
    African clawed frog
    (Xenopus laevis)    		 Amphibia 480178082   -- 78.25(n)    48017808 
    zebrafish
    (Danio rerio)    		 Actinopterygii BI880591.12   -- 79.87(n)    BI880591.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG426846
    		 --
    		 15(a)
    		 1 → many
    		 X(17604178-17645718)
    worm
    (Caenorhabditis elegans)    		 Secernentea gap-23 GTPase-activating protein 43(a)   X(9507707-9551128)   --


    ENSEMBL Gene Tree for DAB2IP (if available)
    TreeFam Gene Tree for DAB2IP (if available) 

    Paralogs
    for DAB2IP gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DAB2IP gene
    SYNGAP12  RASA42  RASA12  RASAL32  RASA22  RASA4B2  RASA32  RASAL22  
    RASAL12  
    4 SIMAP similar genes for DAB2IP using alignment to 5 protein entries:     DAB2P_HUMAN (see all proteins):
    RASAL2    SYNGAP1    FLJ00087    RASAL3

    DAB2IP for paralogs           About GeneDecksing



    Genomic Variants
    for DAB2IP gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3611 NCBI SNPs in DAB2IP are shown (see all 3611)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1878948771,2
    		--124327408(+) GGCACC/TCCAGG 1 -- us2k10--------
    rs1932445631,2
    		--124327410(+) CACTCC/TAGGCC 1 -- us2k10--------
    rs736617561,2
    		C,--124327463(+) CTCCCA/TGTCAC 1 -- us2k12Minor allele frequency- T:0.04WA 120
    rs1825865971,2
    		--124327632(+) GGTTGA/CGCCCA 1 -- us2k10--------
    rs1877124321,2
    		--124327680(+) GTGGCC/TTGGGT 1 -- us2k10--------
    rs1112383091,2
    		C,F,--124327744(+) ATGGAG/CTCTCG 1 -- us2k13Minor allele frequency- C:0.40WA NA CSA 5
    rs1927343391,2
    		--124327803(+) ACCTCC/TGCCTC 1 -- us2k10--------
    rs1847745051,2
    		--124327851(+) TAGCTA/GGAATT 1 -- us2k10--------
    rs1139120171,2
    		C,--124327907(+) GAGATGG/-ATGGG 1 -- us2k11Minor allele frequency- -:0.50CSA 2
    rs2020518721,2
    		--124327913(+) TGGGG-/GCGTTCA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DAB2IP (124329336 - 124547809 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 5 variations for DAB2IP
         2 CNVs: 52703 38971
         3 Indels: 41205 43034 47641
    Human Gene Mutation Database (HGMD): DAB2IP

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    Disorders / Diseases
    for DAB2IP gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DAB2IP for disorders           About GeneDecksing

    OMIM gene information: 609205    OMIM disorders: --

    UniProtKB/Swiss-Prot: DAB2P_HUMAN, Q5VWQ8
  • Note=A chromosomal aberration involving DAB2IP is found in a patient with acute myeloid leukemia (AML).
    • Translocation t(9;11)(q34;q23) with MLL. May give rise to a MLL-DAB2IP fusion protein lacking the PH domain

    11 diseases for DAB2IP:    About MalaCards
    breast cancer    prostatitis    transitional cell carcinoma    acute myeloid leukemia
    myeloid leukemia    prostate cancer    liver cancer    leukemia
    lung cancer    carcinoma    neuronitis

    3 Novoseek disease relationships for DAB2IP gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    prostate cancer 41.6 12 11944990 (3), 20154697 (2), 20332235 (2), 16629596 (1) (see all 5)
    necrosis 11.7 4 17389591 (2), 15817459 (1), 18292600 (1)
    tumors 0 7 20154697 (3), 17389591 (2), 15817459 (1), 18292600 (1)

    Human Genome Epidemiology (HuGE) Navigator: DAB2IP (9 documents)

    Export disorders for DAB2IP gene to outside databases

    Publications
    for DAB2IP gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAB2IP gene, integrated from 9 sources (see all 47):
    (articles sorted by number of sources associating them with DAB2IP)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Differential regulation of the human gene DAB2IP in normal and malignant prostatic epithelia: cloning and characterization. (PubMed id 11944990)1, 2, 3, 9 Chen H.... Hsieh J.-T. (2002)
    2. AIP1 mediates TNF-alpha-induced ASK1 activation by facilitating dissociation of ASK1 from its inhibitor 14-3-3. (PubMed id 12813029)1, 2, 9 Zhang R.... Min W. (2003)
    3. AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2- induced ASK1-JNK activation. (PubMed id 15310755)1, 2, 9 Zhang H.... Min W. (2004)
    4. Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient with de novo acute myeloid leukemia. (PubMed id 14978793)1, 2, 9 von Bergh A.R.M.... Schuuring E. (2004)
    5. DNA sequence and analysis of human chromosome 9. (PubMed id 15164053)1, 2 Humphray S.J.... Dunham I. (2004)
    6. The mechanism of growth-inhibitory effect of DOC-2/DAB2 in prostate cancer. Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2. (PubMed id 11812785)1, 3 Wang Z....Hsieh J.T. (2002)
    7. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    8. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2 Nagase T.... Ohara O. (2000)
    9. RIP1-mediated AIP1 phosphorylation at a 14-3-3-binding site is critical for tumor necrosis factor-induced ASK1-JNK/p38 activation. (PubMed id 17389591)1, 9 Zhang H....Min W. (2007)
    10. AIP1 recruits phosphatase PP2A to ASK1 in tumor necrosis factor-induced ASK1-JNK activation. (PubMed id 18292600)1, 9 Min W....Chen H. (2008)

    External Searches for DAB2IP gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DAB2IP gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 153090 HGNC: 17294 AceView: DAB2IP Ensembl:ENSG00000136848 euGenes: HUgn153090
    ECgene: DAB2IP H-InvDB: DAB2IP

    Other Databases showing DAB2IP gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1743

    Specialized Databases showing DAB2IP gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAB2IP Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DAB2IP Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DAB2IP gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DAB2IP gene:
    Search GeneIP for patents involving DAB2IP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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