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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAB2 Gene

protein-coding   GIFtS: 63
GCID: GC05M039371

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

(Previous name: disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein)...)
 Explore 20 diseases affiliated with
DAB2 via
MalaCards
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Biological research products
for DAB2    

Aliases
for DAB2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Disabled Homolog 2, Mitogen-Responsive Phosphoprotein (Drosophila)1 2
DOC-21 2 3
DOC22 3 5
Differentially-Expressed Protein 22 3
Disabled (Drosophila) Homolog 2 (Mitogen-Responsive Phosphoprotein)1
Disabled Homolog 22

External Ids:    HGNC: 26621   Entrez Gene: 16012   Ensembl: ENSG000001530717   OMIM: 6012365   UniProtKB: P980823   

Export aliases for DAB2 gene to outside databases

Previous GC identifers: GC05M039550 GC05M040463 GC05M039372 GC05M039418 GC05M039417 GC05M039408


Summaries
for DAB2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for DAB2:
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is
down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein
binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine
nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth
factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding
different isoforms have been found for this gene. (provided by RefSeq, Oct 2011)

UniProtKB/Swiss-Prot: DAB2_HUMAN, P98082
Function: Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated
endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to
phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization
motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated
endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to
redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing
proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance
regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required
for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several
receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the
signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin
signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin
preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated
endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell
surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to
SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in
modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction
with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in
cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to
respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process
necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage
adhesion and spreading. May act as a tumor suppressor

Gene Wiki entry for DAB2


Genomic Views
for DAB2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NC_018916.1  NT_006576.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAB2 gene promoter:
         RORalpha1   Elk-1   AML1a   Nkx2-2   HFH-1   Nkx2-5   ZIC2/Zic2   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: DAB2 promoter sequence
   Search SABiosciences Chromatin IP Primers for DAB2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAB2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5p13   Ensembl cytogenetic band:  5p13.1   HGNC cytogenetic band: 5p13

DAB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAB2 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M039371:  view genomic region     (about GC identifiers)

Start:
 39,371,780 bp from pter      End:
 39,462,402 bp from pter
Size:
 90,623 bases      Orientation:
 minus strand

Proteins
for DAB2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: DAB2_HUMAN, P98082 (See protein sequence)
Recommended Name: Disabled homolog 2  
Size: 770 amino acids; 82448 Da
Subunit: Can interact (via PID domain) with LDLR, APP, APLP1 and APLP2, and weakly with INPP5D (via NPXY motifs); the
interaction is impaired by tyrosine phosphorylation of the respective NPXY motifs. Can weakly interact (via PID
domain) with LRP1 (via NPXY motif); the interaction is enhanced by tyrosine phosphorylation of the NPXY motif.
Interacts with LRP2 (via NPXY motif); the interaction is not affected by tyrosine phosphorylation of the NPXY motif.
Interacts with clathrin; in vitro can assemble clathrin triskelia into polyhedral coats. Interacts with AP2A2, ITGB1,
ITGB3, ITGB5, PIAS2, DAB2IP, NOSTRIN, FCHO1, DVL3, EPS15, ITSN1 and EPS15L1. Interacts with SH3KBP1 (via SH3 domains).
Interacts with GRB2; competes with SOS1 for binding to GRB2 and the interaction is enhanced by EGF and NT-3
stimulation. Interacts with MAP3K7; the interaction is induced by TGF-beta stimulation and may mediate TGF-beta
stimulated JNK activation. Interacts with AXIN1 and PPP1CA; the interactions are mutually exclusive. Interacts with
the globular tail of MYO6. Interacts (via DPF motifs) with FCHO2; the interaction is direct and required for
DAB2-mediated LDLR endocytosis. Interacts with LRP6; the interaction involves LRP6 phosphorylation by CK2 and
sequesters LRP6 towards clathrin-mediated endocytosis. Associates with the TGF-beta receptor complex (Probable).
Interacts with SMAD2 and SMAD3; the interactions are enhanced upon TGF-beta stimulation. Interacts with GRB2; the
interaction is enhanced by EGF and NT-3 stimulation. Interacts with SRC; the interaction is enhanced by EGF
stimulation
Subcellular location: Cytoplasm. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane, clathrin-coated pit.
Note=Colocalizes with large insert-containing isoforms of MYO6 at clathrin-coated pits/vesicles. During mitosis is
progressively displaced from the membrane and translocated to the cytoplasm
1 PDB 3D structure from and Proteopedia for DAB2:
2LSW (3D)    
Secondary accessions: A6NES5 Q13598 Q9BTY0 Q9UK04
Alternative splicing: 3 isoforms:  P98082-1   P98082-2   P98082-3   

Explore the universe of human proteins at neXtProt for DAB2: NX_P98082

Post-translational modifications:

  • Phosphorylated. Phosphorylation during mitosis is leading to membrane displacement (By similarity)1
  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_P98082

    • DAB2 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001231800.1  NP_001334.2  

    ENSEMBL proteins: 
     ENSP00000313391   ENSP00000345508   ENSP00000426245   ENSP00000421526   ENSP00000427541  
     ENSP00000425088   ENSP00000421086   ENSP00000439919  
    Reactome Protein details: P98082
    Human Recombinant Protein Products: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein: DAB2
    OriGene Protein Over-expression Lysate: DAB2
    OriGene Custom Protein Services for DAB2 
    GenScript Custom Purified and Recombinant Proteins Services for DAB2
    Novus Biologicals DAB2 Proteins
    Novus Biologicals DAB2 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for DAB2

    Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IEA--
    GO:0005737cytoplasm ----
    GO:0005886plasma membrane ----
    GO:0005905coated pit IDA12857860
    GO:0016324apical plasma membrane IEA--


    DAB2 for ontologies           About GeneDecksing



    DAB2 Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of DAB2
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    Cell Signaling Technology (CST) Antibodies for DAB2 
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    Novus Biologicals DAB2 Antibodies
    Abcam antibodies for DAB2 
    Uscn Antibodies for DAB2
    ThermoFisher Antibodies for DAB2

    Assay Products for DAB2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
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    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for DAB2

    Protein Domains /
    Families
    for DAB2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    DAB2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011993 PH_like_dom
     IPR006020 PTyr_interaction_dom

    Graphical View of Domain Structure for InterPro Entry P98082

    ProtoNet protein and cluster: P98082

    2 Blocks protein families:
    IPB002173 Carbohydrate kinase
    IPB006020 Phosphotyrosine interaction domain


    UniProtKB/Swiss-Prot: DAB2_HUMAN, P98082
    Domain: The PID domain binds to predominantly non-phosphorylated NPXY internalization motifs present in members of the
    LDLR and APP family; it also mediates simultaneous binding to phosphatidylinositol 4,5-bisphosphate (By similarity)
    Domain: The Asn-Pro-Phe (NPF) motifs, which are found in proteins involved in the endocytic pathway, mediate the
    interaction with the EH domain of EPS15, EPS15R and ITSN1 (By similarity)
    Similarity: Contains 1 PID domain


    Function
    for DAB2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: DAB2_HUMAN, P98082
    Function: Adapter protein that functions as clathrin-associated sorting protein (CLASP) required for clathrin-mediated
    endocytosis of selected cargo proteins. Can bind and assemble clathrin, and binds simultaneously to
    phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) and cargos containg non-phosphorylated NPXY internalization
    motifs, such as the LDL receptor, to recruit them to clathrin-coated pits. Can function in clathrin-mediated
    endocytosis independently of the AP-2 complex. Involved in endocytosis of integrin beta-1; this function seems to
    redundant with the AP-2 complex and seems to require DAB2 binding to endocytosis accessory EH domain-containing
    proteins such as EPS15, EPS15L1 and ITSN1. Involved in endocytosis of cystic fibrosis transmembrane conductance
    regulator/CFTR. Involved in endocytosis of megalin/LRP2 lipoprotein receptor during embryonal development. Required
    for recycling of the TGF-beta receptor. Involved in CFTR trafficking to the late endosome. Involved in several
    receptor-mediated signaling pathways. Involved in TGF-beta receptor signaling and facilitates phosphorylation of the
    signal transducer SMAD2. Mediates TFG-beta-stimulated JNK activation. May inhibit the canoniocal Wnt/beta-catenin
    signaling pathway by stabilizing the beta-catenin destruction complex through a competing association with axin
    preventing its dephosphorylation through protein phosphatase 1 (PP1). Sequesters LRP6 towards clathrin-mediated
    endocytosis, leading to inhibition of Wnt/beta-catenin signaling. May activate non-canonical Wnt signaling. In cell
    surface growth factor/Ras signaling pathways proposed to inhibit ERK activation by interrupting the binding of GRB2 to
    SOS1 and to inhibit SRC by preventing its activating phosphorylation at 'Tyr-419'. Proposed to be involved in
    modulation of androgen receptor (AR) signaling mediated by SRC activation; seems to compete with AR for interaction
    with SRC. Plays a role in the CSF-1 signal transduction pathway. Plays a role in cellular differentiation. Involved in
    cell positioning and formation of visceral endoderm (VE) during embryogenesis and proposed to be required in the VE to
    respond to Nodal signaling coming from the epiblast. Required for the epithelial to mesenchymal transition, a process
    necessary for proper embryonic development. May be involved in myeloid cell differentiation and can induce macrophage
    adhesion and spreading. May act as a tumor suppressor

         Genatlas biochemistry entry for DAB2:
    murine disabled-2,mitogen responsive-phosphoprotein p96 homolog,originally identified as a cDNA fragment isolated from
    normal ovarian epithelial cell,expressed in various tissues,putatively involved in cellular transduction

    miRNA
    Products:            		 OriGene 3'-UTR Clone: DAB2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAB2
    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate DAB2 (see all 30):
    hsa-miR-644 hsa-miR-498 hsa-miR-219-1-3p hsa-miR-607 hsa-miR-106a hsa-miR-519a hsa-miR-1297 hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmid: DAB2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAB2 (see all 7)
    OriGene shRNA RFP: DAB2
    OriGene siRNA: DAB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAB2

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for DAB2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for DAB2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DAB2
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: DAB2 (NM_001343)
    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAB2 

    Cell Line
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    Search LifeMap BioReagents cell lines for DAB2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAB2

    Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005178integrin binding IEA--
    GO:0005515protein binding IPI12805222
    GO:0005546phosphatidylinositol-4,5-bisphosphate binding IEA--
    GO:0008022protein C-terminus binding IPI15837803
    GO:0035612AP-2 adaptor complex binding IEA--


    DAB2 for ontologies           About GeneDecksing


    Animal Models:
         Mouse knock-out Dab2tm1.1Cpr for DAB2
         6 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dab2):
     cellular  embryogenesis  growth/size  homeostasis/metabolism  mortality/aging 
     renal/urinary system 

    DAB2 for phenotypes           About GeneDecksing


    Pathways & Interactions
    for DAB2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/12 super-pathways (see all 12) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Clathrin-dependent protein traffic
    		Clathrin-dependent protein traffic1.00
    		wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)0.37
    		Transport_Clathrin-coated vesicle cycle0.66
    		wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)0.35
    2Formation of annular gap junctions
    		Formation of annular gap junctions1.00
    		Lysosomal degradation of gap junction plaques0.92
    		Gap junction degradation0.92
    3Gap junction assembly
    		Gap junction trafficking0.74
    		Gap junction trafficking and regulation0.70
    4Tyrosine Kinases / Adaptors
    		Tyrosine Kinases / Adaptors1.00
    5Cytoskeletal Signaling
    		Cytoskeletal Signaling1.00

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    1 EMD Millipore Pathway for DAB2
        Clathrin-dependent protein traffic

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DAB2
        SMAD Signaling Network

    2 Cell Signaling Technology (CST) Pathways for DAB2
        Cytoskeletal Signaling
    Tyrosine Kinases / Adaptors

    4 GeneGo (Thomson Reuters) Pathways for DAB2
        wtCFTR and delta508-CFTR traffic / Generic schema (norm and CF)
    Cholesterol and Sphingolipids transport / Influx to the early endosome in lung (normal and CF)
    wtCFTR and delta508 traffic / Clathrin coated vesicles formation (norm and CF)
    Transport Clathrin-coated vesicle cycle

    3 BioSystems Pathways for DAB2 
        TGF-beta Receptor Signaling Pathway
    Wnt Signaling Pathway NetPath
    TGF-beta receptor signaling

    5/6        Reactome Pathways for DAB2 (see all 6)
        Gap junction degradation
    Gap junction trafficking
    Lysosomal degradation of gap junction plaques
    Membrane Trafficking
    Formation of annular gap junctions


    1         Kegg Pathway  (Kegg details for DAB2):
        Endocytosis


    DAB2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAB2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/49 Interacting proteins for DAB2 (P980821, 2, 3 ENSP000003133914) via UniProtKB, MINT, STRING, and/or I2D (see all 49)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LRP6O755812MINT-8383369 MINT-8383520 MINT-8383467 MINT-8383354 MINT-8383493 MINT-8383480 MINT-8382936 MINT-8383325 MINT-8383417 MINT-8383507 MINT-8383533 MINT-8382947 MINT-8383280 MINT-8383454 MINT-8382960 MINT-8383399 MINT-8383303 MINT-8382978 MINT-8383384 MINT-8383339
    SMAD2Q157961, 3, ENSP000002621604EBI-1171238,EBI-1040141 I2D: score=3 STRING: ENSP00000262160
    SMAD3P840221, 3, ENSP000003329734EBI-1171238,EBI-1965323 I2D: score=3 STRING: ENSP00000332973
    FYNP062412, 3, ENSP000003576564MINT-8111079 I2D: score=2 STRING: ENSP00000357656
    PIK3R1P279862, 3, ENSP000002743354MINT-8111775 I2D: score=2 STRING: ENSP00000274335
    About this table

    Gene Ontology (GO): 5/35 biological process terms (GO ID links to tree view) (see all 35):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000904cell morphogenesis involved in differentiation IEA--
    GO:0001701in utero embryonic development IEA--
    GO:0001921positive regulation of receptor recycling IEA--
    GO:0001934positive regulation of protein phosphorylation IMP12805222
    GO:0006907pinocytosis IEA--


    DAB2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for DAB2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    DAB2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DAB2
    4 Novoseek chemical compound relationships for DAB2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    phosphotyrosine 47.7 5 10769163 (1), 15134832 (1), 9620555 (1), 11387212 (1)
    retinoic acid 37.4 10 11577091 (2), 18567755 (1), 11437382 (1)
    fibrinogen 14.7 7 15280374 (4), 17074833 (2), 19956625 (1)
    zinc 0 1 10779506 (1)

    Search CenterWatch for drugs/clinical trials and news about DAB2 

    Transcripts
    for DAB2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for DAB2 gene (2 alternative transcripts): 
    NM_001244871.1  NM_001343.3  

    Unigene Cluster for DAB2:

    Disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
    Hs.696631  [show with all ESTs]
    Unigene Representative Sequence: NM_001343
    17 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320816 ENST00000339788 ENST00000509337 ENST00000502879 ENST00000512525
    ENST00000505968 ENST00000507539 ENST00000511792 ENST00000503513 ENST00000515700
    ENST00000513052 ENST00000515269 ENST00000511536 ENST00000509457 ENST00000502388
    ENST00000507990(uc003jly.3) ENST00000545653(uc003jlx.3 uc003jlw.3)


    miRNA
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    8/30 QIAGEN miScript miRNA Assays for microRNAs that regulate DAB2 (see all 30):
    hsa-miR-644 hsa-miR-498 hsa-miR-219-1-3p hsa-miR-607 hsa-miR-106a hsa-miR-519a hsa-miR-1297 hsa-miR-141*
    SwitchGear 3'UTR luciferase reporter plasmid: DAB2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for DAB2 (see all 7)
    OriGene shRNA RFP: DAB2
    OriGene siRNA: DAB2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAB2
    Clone
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    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for DAB2
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    GenScript: all cDNA clones in your preferred vector: DAB2 (NM_001343)
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    Additional cDNA sequence: 

    AF188298.1 AK024965.1 AK092836.1 AK123803.1 AK130136.1 AK297984.1 AK314381.1 BC003064.2 
    L16886.1 U39050.1 U53446.1 

    24/32 DOTS entries (see all 32):

    DT.95295254  DT.91666734  DT.40118362  DT.455279  DT.95318363  DT.100883169  DT.120858679  DT.455793 
    DT.100017789  DT.100883170  DT.97781179  DT.95318357  DT.97771402  DT.100802060  DT.100883171  DT.100883161 
    DT.87079455  DT.91767409  DT.427845  DT.100701331  DT.120858649  DT.305784  DT.91767407  DT.95318362 

    24/541 AceView cDNA sequences (see all 541):

    BM728802 AK130136 BM970837 AI126988 BE549870 BP346322 AA400292 R80673 
    AL702169 BI493358 BP345737 AA907401 AK123803 AA978370 AW664299 AL701508 
    BP346425 BM972924 AI796298 D79142 BP346048 AI148831 CF528390 AW188174 

    GeneLoc Exon Structure

    5/15 Alternative Splicing Database (ASD) splice patterns (SP) for DAB2 (see all 15)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11a · 11b ^ 12a · 12b ^ 13 ^ 14 ^ 15a · 15b ^
    SP1:                    -     -     -     -     -                 -                       -                                                                     
    SP2:                                                                                      -                                                                     
    SP3:                                                                                                                                                            
    SP4:                    -           -     -     -                 -                                                                                             
    SP5:                    -     -     -     -     -                 -                                                                                             

    ExUns: 16 ^ 17 ^ 18 ^ 19a · 19b ^ 20
    SP1:                                    
    SP2:                                    
    SP3:                                    
    SP4:                                    
    SP5:                                    


    ECgene alternative splicing isoforms for DAB2

    Expression
    for DAB2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAB2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: CACTTTTCTG

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    DAB2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    5 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    EndodermDefinitive EndodermDefinitive Endoderm CellsEarly Embryo, Endoderm
    EpiblastEpiblastEarly Epiblast CellsEarly Embryo
    HypoblastHypoblastHypoblast CellsExtraembryonic Tissues
    HypoblastVisceral EndodermEarly Distal Visceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    HypoblastVisceral EndodermVisceral Endoderm CellsExtraembryonic Tissues, Yolk Sac
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 3 LifeMap Cells 
    NameCategory
    Extra-embryonic endoderm cells (Fetal Stem / Progenitor Cell)Extraembryonic Tissues
    Extraembryonic endoderm-like cells (Generation of extrae...)
    N2/LSB/S/F8/CHIR-induced cells (Generation of midbra...)

    See DAB2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAB2

    SOURCE GeneReport for Unigene cluster: Hs.696631

    UniProtKB/Swiss-Prot: DAB2_HUMAN, P98082
    Tissue specificity: Expressed in deep invaginations, inclusion cysts and the surface epithelial cells of the ovary.
    Also expressed in breast epithelial cells, spleen, thymus, prostate, testis, macrophages, fibroblasts, lung epithelial
    cells, placenta, brain stem, heart and small intestine. Expressed in kidney proximal tubular epithelial cells (at
    protein level)

        SABiosciences Expression via Pathway-Focused PCR Arrays including DAB2: 
              WNT Signaling Targets in human mouse rat
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              Signal Transduction PathwayFinder in human mouse rat

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    In Situ
    Assay Products:     
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    Orthologs
    for DAB2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for DAB2 gene from 7/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Dab21 , 5 disabled homolog 2 (Drosophila)5
    disabled 2, mitogen-responsive phosphoprotein1    		 86.02(n)1
    84.4(a)1    		   15 (2.15 cM)5
    131321  NM_023118.51  NP_075607.21 
     62997885 
    chicken
    (Gallus gallus)    		 Aves LOC4274491 disabled homolog 2-like 70.29(n)
    66.37(a)    		   427449  XM_003642931.1  XP_003642979.1 
    lizard
    (Anolis carolinensis)    		 Reptilia DAB26
    		 --
    		 59(a)
    		 1 ↔ 1
    		 2(7553098-7578139)
    African clawed frog
    (Xenopus laevis)    		 Amphibia BC060027.12   -- 75.75(n)    BC060027.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii Dr.94432 Danio rerio Dab2 mRNA, complete cds 75.8(n)    BC057504.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Dab6
    		 Disabled
    		 8(a)
    		 1 → many
    		 3L(16705226-16717675)
    worm
    (Caenorhabditis elegans)    		 Secernentea dab-16
    		 DAB (Drosophila disabled) homolog family member (d...
    		 21(a)
    		 1 → many
    		 II(8226082-8229100)


    ENSEMBL Gene Tree for DAB2 (if available)
    TreeFam Gene Tree for DAB2 (if available) 

    Paralogs
    for DAB2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DAB2 gene
    DAB12  

    DAB2 for paralogs           About GeneDecksing



    Genomic Variants
    for DAB2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1091 NCBI SNPs in DAB2 are shown (see all 1091)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 5 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs802988721,2
    		F,--39322959(+) CATGCA/GACAGC 2 -- ds50011Minor allele frequency- G:0.08WA 118
    rs623583901,2
    		F,--39323223(+) GGTAAT/ATTACT 2 -- ds50011Minor allele frequency- A:0.03NA 120
    rs563627601,2
    		C,--39323412(+) TGAAAT/AGAGTA 2 -- ut312Minor allele frequency- A:0.06WA 120
    rs144541,2
    		F--39323475(+) CAAAAC/AAGTTG 2 -- ut311Minor allele frequency- A:0.31MN 184
    rs25427081,2
    		H--39323518(+) ACCTAG/AAAATA 2 -- ut314Minor allele frequency- A:0.00NS EA 400
    rs25427091,2
    		H--39323593(+) ATAGTG/AACTGA 2 -- ut314Minor allele frequency- A:0.00NS EA 420
    rs174706671,2
    		C,F,H,--39323682(+) GGGCTA/GATCAA 2 -- ut3120Minor allele frequency- G:0.03NA NS EA MN 2054
    rs25842461,2
    		H--39323706(+) GGCCCC/ATGTCT 2 -- ut314Minor allele frequency- A:0.00NS EA 416
    rs1139361521,2
    		F--39323800(+) ATTAAG/AGGTCA 2 -- ut312Minor allele frequency- A:0.50CSA 4
    rs25842471,2
    		H--39323831(+) AACATA/TAACAA 2 -- ut314Minor allele frequency- T:0.00NS EA 416

    HapMap Linkage Disequilibrium report for DAB2 (39371780 - 39462402 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 1 variation for DAB2
         1 Indel: 40752
    Human Gene Mutation Database (HGMD): DAB2

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    Disorders / Diseases
    for DAB2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    DAB2 for disorders           About GeneDecksing

    OMIM gene information: 601236    OMIM disorders: --

    20 diseases for DAB2:    About MalaCards
    ovarian carcinoma    carcinoma    dent disease    teratocarcinoma
    epithelial ovarian cancer    ovarian cancer    cystic fibrosis    embryonal carcinoma
    kidney disease    breast cancer    aldosteronism    fibrosis
    gastric cancer    nasopharyngitis    meningioma    lung cancer
    prostate cancer    cholesterol    prostatitis    leukemia

    10/11 Novoseek disease relationships for DAB2 gene (see all 11)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian carcinoma 56.5 8 14669280 (2), 11039902 (1), 10340382 (1), 12015763 (1) (see all 7)
    teratocarcinoma 56.2 2 15734730 (1)
    ovarian cancer 35.6 8 11359772 (2), 17009406 (1), 11368898 (1), 9620555 (1)
    epithelial tumor 29.5 3 10340382 (1), 16816378 (1)
    premalignant 22.4 4 12015763 (4)
    carcinoma 17.4 2 9620555 (1), 11161789 (1)
    tumors 10.2 49 12015763 (7), 10340382 (5), 11039902 (3), 12365030 (3) (see all 11)
    breast cancer 2.86 4 11039902 (1), 18567755 (1), 11359772 (1)
    cancer 0 8 12365030 (2), 11368898 (1), 16816378 (1), 11359772 (1) (see all 5)
    cysts 0 1 14669280 (1)

    Human Genome Epidemiology (HuGE) Navigator: DAB2 (9 documents)

    Export disorders for DAB2 gene to outside databases

    Publications
    for DAB2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAB2 gene, integrated from 9 sources (see all 132):
    (articles sorted by number of sources associating them with DAB2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer. (PubMed id 9620555)1, 2, 3, 9 Mok S.C.... Berkowitz R.S. (1998)
    2. Sequence, genomic structure, and chromosomal assignment of human DOC- 2. (PubMed id 8660969)1, 2, 3, 9 Albertsen H.M.... White R. (1996)
    3. Disabled-2 inactivation is an early step in ovarian tumorigenicity. (PubMed id 10340382)1, 2, 9 Fazili Z.... Xu X.-X. (1999)
    4. Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2). (PubMed id 11161789)1, 2, 9 Sheng Z.... Xu X.-X. (2000)
    5. The adaptor protein Dab2 sorts LDL receptors into coated pits independently of AP-2 and ARH. (PubMed id 16984970)1, 2, 9 Maurer M.E. and Cooper J.A. (2006)
    6. Dab2 links CIN85 with clathrin-mediated receptor internalization. (PubMed id 14596919)1, 2, 9 Kowanetz K.... Dikic I. (2003)
    7. The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway. (PubMed id 11387212)1, 2, 9 Hocevar B.A....Howe P.H. (2001)
    8. The adaptor disabled-2 binds to the third psi xNPxY sequence on the cytoplasmic tail of megalin. (PubMed id 15134832)1, 2, 9 Gallagher H....Newman D.J. (2004)
    9. Cytosolic adaptor protein Dab2 is an intracellular ligand of endocytic receptor gp600/megalin. (PubMed id 10769163)1, 2, 9 Oleinikov A.V....Makker S.P. (2000)
    10. FCH domain only-2 organizes clathrin-coated structures and interacts with Disabled-2 for low-density lipoprotein receptor endocytosis. (PubMed id 22323290)1, 2 Mulkearns E.E. and Cooper J.A. (2012)

    External Searches for DAB2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing DAB2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1601 HGNC: 2662 AceView: DAB2 Ensembl:ENSG00000153071 euGenes: HUgn1601
    ECgene: DAB2 Kegg: 1601 H-InvDB: DAB2

    Other Databases showing DAB2 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing DAB2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAB2 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for DAB2 Genetics and Cytogenetics in Oncology and Haematology

    Intellectual Property
    for DAB2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for DAB2 gene:
    Search GeneIP for patents involving DAB2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

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