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DAB2 Gene

protein-coding GIFtS: 63

GC05M039408

disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
(Previous name: disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein) )
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
DOC-2 ^¹, ², ³
DOC2 ^², ³, ⁵
FLJ26626 ^²

Descriptions
Differentially-expressed protein 2 ^³
disabled (Drosophila) homolog 2 (mitogen-responsive phosphoprotein) ^¹
disabled homolog 2 ^²
disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) ^²
mitogen-responsive phosphoprotein ^²

External Ids
HGNC: 2662¹
Entrez Gene: 1601²
UniProtKB: P98082³
Ensembl: ENSG00000153071⁷

Search outside databases for aliases for DAB2 gene

Previous GC identifers: GC05M039550 GC05M040463 GC05M039372 GC05M039418 GC05M039417

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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EntrezGene summary for DAB2:

DAB2 mRNA is expressed in normal ovarian epithelial cells but is down-regulated or absent from

ovarian carcinoma cell lines. The 770-amino acid predicted protein has an overall 83% identity

with the mouse p96 protein, a putative mitogen-responsive phosphoprotein; homology is strongest in

the amino-terminal end of the protein in a region corresponding to the phosphotyrosine interaction

domain. The down-regulation of DAB2 may play an important role in ovarian carcinogenesis. This

gene was initially named DOC2 (for Differentially expressed in Ovarian Cancer) and is distinct

from the DOC2A and DOC2B genes (for double C2-like domains, alpha and beta). [provided by RefSeq]

UniProtKB/Swiss-Prot: DAB2_HUMAN, P98082

Function: Component of the CSF-1 signal transduction pathway (By similarity)

Gene Wiki entry for DAB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the DAB2 gene

Entrez Gene cytogenetic band: 5p13 Ensembl cytogenetic band: 5p13.1 HGNC cytogenetic band: 5p13

DAB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M039408: (about GC identifiers)

Start:	39,407,537 bp from pter
End:	39,461,092 bp from pter
Size:	53,556 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000005.8 NT_006576.15

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: DAB2_HUMAN, P98082 (See protein sequence)

Recommended Name: Disabled homolog 2

Size: 770 amino acids; 82448 Da

Subunit: Interacts with the globular tail of MYO6. Interacts with DAB2IP. Interacts with NOSTRIN

(By similarity)

Subcellular location: Cytoplasmic vesicle, clathrin-coated vesicle membrane. Membrane,

clathrin-coated pit. Note=Colocalizes with large insert-containing isoforms of MYO6 at

clathrin-coated pits/vesicles

Secondary accessions: A6NES5 Q13598 Q9BTY0 Q9UK04

Alternative splicing: 2 isoforms: P98082-1 P98082-2

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_001334.2

ENSEMBL proteins:

ENSP00000313391 ENSP00000345508

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (DAB2)
	Human Recombinant Proteins from Abnova (DAB2)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

3 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005905	coated pit	IDA	12857860
GO:0016020	membrane	IEA	--
GO:0031410	cytoplasmic vesicle	IEA	--

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Antibodies for DAB2:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for DAB2
	Browse R&D Systems for Antibodies
	Antibodies from Abcam (DAB2), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (DAB2)
	Novus Biologicals Antibodies for DAB2

Assays for DAB2:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P98082

ProtoNet protein and cluster: P98082

2 Blocks protein families:

IPB002173 Carbohydrate kinase

IPB006020 Phosphotyrosine interaction domain

UniProtKB/Swiss-Prot: DAB2_HUMAN, P98082

Similarity: Contains 1 PID domain

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAB2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001343

Applied Biosystems Silencer® siRNAs for DAB2

Sigma-Aldrich siRNA and siRNA Panels for DAB2

Sigma-Aldrich shRNA for DAB2

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for DAB2
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_001343
Myc/DDK tagged cDNA clone in CMV expression vector: NM_001343
untagged cDNA clone in CMV expression vector: NM_001343

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_001343

UniProtKB/Swiss-Prot: DAB2_HUMAN, P98082

Function: Component of the CSF-1 signal transduction pathway (By similarity)

Genatlas biochemistry entry for DAB2:

murine disabled-2,mitogen responsive-phosphoprotein p96 homolog,originally identified as a cDNA

fragment isolated from normal ovarian epithelial cell,expressed in various tissues,putatively

involved in cellular transduction

5 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Dab2):

embryogenesis

growth/size

homeostasis/metabolism

lethality-prenatal/perinatal

renal/urinary system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008022	protein C-terminus binding	IPI	15837803

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
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1 Sigma-Aldrich "Your Favorite Gene" Pathway for DAB2 (Your Favorite Gene powered by Ingenuity)

Clathrin-mediated Endocytosis

GeneDecks DAB2 for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for DAB2

5/40 Interacting proteins for DAB2 (ENSP00000313391³ P98082^{1, 2}) via UniProtKB, MINT, and/or STRING (see all 40 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
GRB2	P62993¹	STRING (score=.98) EBI-1171238, EBI-401755
FYN	P06241¹	EBI-1171238, EBI-515315
NCK1	P16333¹	EBI-1171238, EBI-389883
PIK3R1	P27986¹	EBI-1171238, EBI-79464
SMURF2	Q9HAU4²	MINT-61795

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1 Gene Ontology (GO) biological process term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0008283	cell proliferation	TAS	9620555

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(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for DAB2
3 Novoseek chemical compound relationships for DAB2 gene

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
phosphotyrosine	49.98	5	10769163 (1), 15134832 (1), 9620555 (1), 11387212 (1)
fibrinogen	4.82	6	15280374 (4), 17074833 (2)
zinc	0.00	1	10779506 (1)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (DAB2)
		Browse for Gene Knock-down Tools from Millipore
		Browse Abnova for Chimera RNAi Products

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_001343

Sigma-Aldrich siRNA and siRNA Panels for DAB2

Sigma-Aldrich shRNA for DAB2

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001343

REFSEQ mRNAs for DAB2 gene:

NM_001343.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001343

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_001343
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_001343
                                 untagged cDNA clone in CMV expression vector: NM_001343

Additional cDNA sequence:

AF188298.1 AK024965.1 AK092836.1 AK123803.1 AK130136.1 AK297984.1 AK314381.1 BC003064.2

BC026261.1 CR606825.1 CR611289.1 CR620235.1 L16886.1 U39050.1 U53446.1

24/38 DOTS entries (see all 38 ):

DT.95295254 DT.91666734 DT.455279 DT.40118362 DT.95318363 DT.455793 DT.100017789 DT.100883169

DT.120858679 DT.100883170 DT.95318357 DT.97781179 DT.100802060 DT.97771402 DT.100883171 DT.120858458

DT.91767409 DT.100883161 DT.87079455 DT.97833522 DT.427845 DT.100701331 DT.100883164 DT.120858649

24/541 AceView cDNA sequences (see all 541 ):

R71342 H89096 BP346322 AL702169 R80673 BQ772367 CA412959 AA320637

CF528390 D79142 BP346048 AI148831 BP334808 AI401453 BM972924 BE327015

AW068037 CA447738 CF125630 AU138088 BQ940105 CR606825 BQ573780 BP345737

highest scoring ESTs for DAB2:

U53446 AA478971 AA480018 AL550853 AL701508 AL701681 AW449897 AW451562 BC003064 BI760460

Unigene Cluster for DAB2:

Disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)

Hs.481980 [show with all ESTs]

Unigene Representative Sequence: NM_001343

GeneLoc Exon Structure

5/15 Alternative Splicing Database (ASD) splice patterns (SP) for DAB2 (see all 15 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	^	7a	·	7b	^	8a	·	8b	^	9a	·	9b	^	10	^	11a	·	11b	^	12a	·	12b	^	13	^	14	^	15a	·	15b	^
SP1:							-		-		-		-		-						-								-
SP2:																													-
SP3:
SP4:							-				-		-		-						-
SP5:							-		-		-		-		-						-

ExUns:	16	^	17	^	18	^	19a	·	19b	^	20
SP1:
SP2:
SP3:
SP4:
SP5:

About this scheme

ECgene alternative splicing isoforms for DAB2

2 Ensembl transcripts including schematic representations:

ENST00000320816 ENST00000339788

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
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DAB2 expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for DAB2

¹ / ² / ³

15 probe-sets matching DAB2 gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
66805_at²^{, 3}	U95-C	1	1.00	1.00	0.46	0.27	AI733354	0.60	1.00	0.82	1
45341_at²^{, 3}	U95-B	1	1.00	1.00	0.96	1.04	N25096	0.60	1.00	0.82	1
479_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.96	U53446	1.00	1.00	1.00	1
210757_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF188298	0.60	1.00	0.82	1
201278_at²^{, 3}	U133-A	1	1.00	1.00	--	--	N21202	0.40	1.00	0.76	1
232898_at²^{, 3}	U133-B	1	1.00	1.00	--	--	R79120	0.40	1.00	0.76	1
201279_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	BC003064	0.80	1.00	0.91	1
201280_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_001343	0.60	1.00	0.82	1
240873_x_at²^{, 3}	U133-B	1	0.36	1.00	--	--	R62907	0.40	1.00	0.76	1
210757_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201278_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
232898_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201279_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
201280_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
240873_x_at²	U133Plus2	1	0.36	1.00	--	--	--	--	--	--	--

GeneDecks DAB2 for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: CACTTTTCTG

SOURCE GeneReport for Unigene cluster: Hs.481980
Expression variation in blood from EXPOLDB for DAB2
UniProtKB/Swiss-Prot: DAB2_HUMAN, P98082
Tissue specificity: Expressed in deep invaginations, inclusion cysts and the surface epithelial
cells of the ovary. Also expressed in breast epithelial cells, spleen, thymus, prostate, testis,
macrophages, fibroblasts, lung epithelial cells, placenta, brain stem, heart and small intestine

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for DAB2 gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	DAB2¹	--	disabled homolog 2, mitogen-responsive phosphoprotein more	91.28(n) 89.59(a)	479353 XM_862965.1 XP_868058.1
chimpanzee (Pan troglodytes)	DAB2¹	--	disabled homolog 2, mitogen-responsive phosphoprotein more	99.35(n) 99.22(a)	461905 XM_517792.2 XP_517792.2
cow (Bos taurus)	DAB2¹	--	disabled homolog 2, mitogen-responsive phosphoprotein more	89.78(n) 86.88(a)	509221 XM_879138.2 XP_884231.1
rat (Rattus norvegicus)	Dab2¹	--	disabled homolog 2, mitogen-responsive phosphoprotein more	86.76(n) 84.27(a)	79128 NM_024159.1 NP_077073.1
mouse (Mus musculus)	Dab2^{1, 5}	15 (6.70 cM)⁵	disabled homolog 2 (Drosophila)^{1, 5}	85.98(n)¹ 84.4(a)¹	13132¹ NM_023118.3¹ NP_075607.2¹ AA407284⁵ AA960054⁵ (see all 27)

About this table Species with no ortholog for DAB2

ENSEMBL Gene Tree for DAB2

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
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Paralogs for DAB2 gene

DAB1²

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/454 NCBI SNPs in DAB2 are shown (see all 454 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 220)

AB	SNP ID	Valid	Chr 5 pos	Sequence	Recs	AA Chg	Type	More	Recs	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--			--
	rs1046033^1,2	A,C,F,H	39407907(-)	`TCCAAT/CGTTAC`	1	--	ut3¹		10	EA MN EU WA	2464
	rs4578^1,2	A,C,F,H	39409010(-)	`ACCCTG/ACCTCT`	1	--	ut3¹ ese³		10	MN EA NA EU WA	2298
	rs7704942^1,2	A,C,F,H	39407250(+)	`ATTTTA/GTAGTG`	1	--	ng5¹		5	NA EA	318
	rs9292743^1,2	A,C,F,H	39463058(+)	`ATATTT/CACCCT`	1	--	ng3¹		2	EA	174
	rs3812040^1,2	A,C,F,H	39461777(-)	`CAATAA/GTTCTT`	1	--	ng3¹ tfbs³		4	EU EA WA	386
	rs3828651^1,2	A,C,F,H	39462208(-)	`AGGCTG/AGGGAA`	1	--	ng3¹		4	EU EA WA	404
	rs3733801^1,2	C,F,H	39412745(-)	`CTCCAG/ATGATG`	1	N/S	mis¹ ese³		12	EU EA WA	1260
	rs1050903^1,2	C,F,H	39430250(-)	`TGAGAC/GTTCTC`	1	--	ut5¹ ese³		8	MN NA EU EA WA	742
	rs9292742^1,2	C,F,H	39462981(+)	`CATCTA/CAGTTG`	1	--	ng3¹		12	EA NA EU WA	1054
	rs13179493^1,2	C,F,H	39462064(+)	`TAGCCT/CCGACT`	1	--	ng3¹		8	EU EA WA	838

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HapMap Linkage Disequilibrium images for DAB2 (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 601236

10/11 Novoseek disease relationships for DAB2 gene (see all 11 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian carcinoma	58.91	8	14669280 (2), 11039902 (1), 10340382 (1), 12015763 (1) (see all 7)
teratocarcinoma	58.24	2	15734730 (1)
ovarian cancer	38.98	8	11359772 (2), 17009406 (1), 11368898 (1), 9620555 (1)
epithelial tumor	32.66	3	10340382 (1), 16816378 (1)
premalignant	25.54	4	12015763 (4)
carcinoma	20.70	2	9620555 (1), 11161789 (1)
tumors	14.61	49	12015763 (7), 10340382 (5), 11039902 (3), 12365030 (3) (see all 11)
breast cancer	7.11	4	11039902 (1), 18567755 (1), 11359772 (1)
hyperplasia	0.00	4	17009406 (3), 16816378 (1)
cancer	0.00	8	12365030 (2), 11368898 (1), 16816378 (1), 11359772 (1) (see all 5)

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Human Genome Epidemiology Navigator: DAB2 (1 document)

(Possibly Related Articles in Doctor's Guide)
About This Section

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/86 PubMed articles for DAB2 gene (see all 86 ):

DOC-2, a candidate tumor suppressor gene in human epithelial ovarian cancer. (PubMed id 9620555)^{1, 2, 3, 4} Mok S.C....Berkowitz R.S. (1998)
Sequence, genomic structure, and chromosomal assignment of human DOC- 2. (PubMed id 8660969)^{1, 2, 3, 4} Albertsen H.M.... White R. (1996)
Disabled-2 inactivation is an early step in ovarian tumorigenicity. (PubMed id 10340382)^{1, 3, 4} Fazili Z.... Xu X.-X. (1999)
Structure, sequence, and promoter analysis of human disabled-2 gene (DAB2). (PubMed id 11161789)^{1, 3, 4} Sheng Z.... Xu X.-X. (2000)
A probability-based approach for high-throughput protein phosphorylation analysis and site localization. (PubMed id 16964243)^{3, 4} Beausoleil S.A.... Gygi S.P. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{3, 4} Olsen J.V....Mann M. (2006)
Large-scale characterization of HeLa cell nuclear phosphoproteins. (PubMed id 15302935)^{3, 4} Beausoleil S.A....Gygi S.P. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
Myosin VI binds to and localises with Dab2, potentially linking receptor-mediated endocytosis and the actin cytoskeleton. (PubMed id 11967127)^{3, 4} Morris S.M.... Buss F. (2002)
Molecular cloning of differentially expressed genes in human epithelial ovarian cancer. (PubMed id 8314147)^{3, 4} Mok S.C....Berkowitz R.S. (1994)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 1601	HGNC: 2662	AceView: DAB2	Ensembl:ENSG00000153071	euGenes: HUgn1601
ECgene: DAB2	H-InvDB: DAB2

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
ATLAS Chromosomes in Cancer entry for DAB2	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for DAB2
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for DAB2:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for DAB2-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for DAB2		Antibodies for DAB2
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for DAB2		Browse small molecules at Sigma-Aldrich
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	Flow Cytometry Kits		Protease Activity Assays & Reagents
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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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Antibodies for DAB2

GeneCards Homepage - Last full update: 2 Jul 2009 Incremental update: 13 Oct 2009

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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DAB2 Gene at Home site.
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DAB2 Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for DAB2

Summaries
for DAB2

Genomic Location
for DAB2

Proteins
for DAB2

Protein Domains/
Families
for DAB2

Gene Function
for DAB2

Pathways & Interactions
for DAB2

Drugs & Compounds
for DAB2

Transcripts
for DAB2

Expression
for DAB2

Orthologs
for DAB2

Paralogs
for DAB2

SNPs/Variants
for DAB2

Disorders & Mutations
for DAB2

Medical News
for DAB2

Publications
for DAB2

Search for DAB2

Genome Databases showing DAB2

Other Databases showing DAB2

Specialized Databases showing DAB2

Licensable Technologies
for DAB2

Services
for DAB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

DAB2 Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor DAB2

Summariesfor DAB2

Genomic Locationfor DAB2

Proteinsfor DAB2

Protein Domains/Familiesfor DAB2

Gene Functionfor DAB2

Pathways & Interactionsfor DAB2

Drugs & Compoundsfor DAB2

Transcriptsfor DAB2

Expression for DAB2

Orthologsfor DAB2

Paralogsfor DAB2

SNPs/Variantsfor DAB2

Disorders & Mutationsfor DAB2

Medical Newsfor DAB2

Publicationsfor DAB2

Search for DAB2

Genome Databases showing DAB2

Other Databases showing DAB2

Specialized Databases showing DAB2

Licensable Technologiesfor DAB2

Servicesfor DAB2

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for DAB2

Summaries
for DAB2

Genomic Location
for DAB2

Proteins
for DAB2

Protein Domains/
Families
for DAB2

Gene Function
for DAB2

Pathways & Interactions
for DAB2

Drugs & Compounds
for DAB2

Transcripts
for DAB2

Expression
for DAB2

Orthologs
for DAB2

Paralogs
for DAB2

SNPs/Variants
for DAB2

Disorders & Mutations
for DAB2

Medical News
for DAB2

Publications
for DAB2

Licensable Technologies
for DAB2

Services
for DAB2