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Aliases for DAAM2 Gene

Aliases for DAAM2 Gene

  • Dishevelled Associated Activator Of Morphogenesis 2 2 3 5
  • Disheveled-Associated Activator Of Morphogenesis 2 3
  • DJ90A20A.1 3
  • KIAA0381 4

External Ids for DAAM2 Gene

Previous GeneCards Identifiers for DAAM2 Gene

  • GC06P039837
  • GC06P039807
  • GC06P039868
  • GC06P039535

Summaries for DAAM2 Gene

GeneCards Summary for DAAM2 Gene

DAAM2 (Dishevelled Associated Activator Of Morphogenesis 2) is a Protein Coding gene. Diseases associated with DAAM2 include Intestinal Volvulus. Among its related pathways are Wnt Signaling Pathway and Pluripotency and WNT Signaling. GO annotations related to this gene include binding and Rho GTPase binding. An important paralog of this gene is DAAM1.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAAM2 Gene

Genomics for DAAM2 Gene

Regulatory Elements for DAAM2 Gene

Enhancers for DAAM2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F039769 1.1 FANTOM5 21.7 -23.1 -23067 0.2 DAAM2 KIF6
GH06F039812 1.2 Ensembl ENCODE 17.4 +21.1 21098 2.3 CTCF PKNOX1 BHLHE40 KLF17 ZIC2 NR2F2 RAD51 ZNF341 WT1 DAAM2 ENSG00000281969
GH06F039879 1.2 FANTOM5 Ensembl ENCODE 16.8 +92.5 92519 9.8 ELF3 ZNF48 ZSCAN9 RARA MIXL1 THAP11 KLF11 HMG20B CEBPB MIER2 DAAM2 MOCS1 LOC100505635 ENSG00000281969
GH06F039820 1 Ensembl ENCODE 11.5 +30.7 30650 4.3 PKNOX1 ZFP64 FEZF1 RAD21 ZNF335 SCRT2 ZNF202 ZNF680 ZNF654 ZBTB11 ANKRD18EP DAAM2 SAYSD1 ENSG00000281969 LOC100505635
GH06F039818 1.2 FANTOM5 Ensembl ENCODE 11.2 +26.9 26913 2.0 DAAM2 ENSG00000281969 LOC100505635
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around DAAM2 on UCSC Golden Path with GeneCards custom track

Promoters for DAAM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001216296 702 2001 CTCF PKNOX1 L3MBTL2 HLF ZBTB8A ZIC2 E2F1 ZBTB48 PRDM10 PRDM1

Genomic Location for DAAM2 Gene

Chromosome:
6
Start:
39,792,298 bp from pter
End:
39,904,877 bp from pter
Size:
112,580 bases
Orientation:
Plus strand

Genomic View for DAAM2 Gene

Genes around DAAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAAM2 Gene

Proteins for DAAM2 Gene

  • Protein details for DAAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T65-DAAM2_HUMAN
    Recommended name:
    Disheveled-associated activator of morphogenesis 2
    Protein Accession:
    Q86T65
    Secondary Accessions:
    • G5EA45
    • Q5T4T8
    • Q5T4U0
    • Q9NQI5
    • Q9Y4G0

    Protein attributes for DAAM2 Gene

    Size:
    1068 amino acids
    Molecular mass:
    123499 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20835.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DAAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAAM2 Gene

Post-translational modifications for DAAM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for DAAM2 Gene

Domains & Families for DAAM2 Gene

Suggested Antigen Peptide Sequences for DAAM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86T65

UniProtKB/Swiss-Prot:

DAAM2_HUMAN :
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Belongs to the formin homology family.
Domain:
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Contains 1 DAD (diaphanous autoregulatory) domain.
  • Contains 1 FH1 (formin homology 1) domain.
  • Contains 1 FH2 (formin homology 2) domain.
  • Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Family:
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with DAAM2: view

No data available for Gene Families for DAAM2 Gene

Function for DAAM2 Gene

Gene Ontology (GO) - Molecular Function for DAAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0017048 Rho GTPase binding IEA --
genes like me logo Genes that share ontologies with DAAM2: view
genes like me logo Genes that share phenotypes with DAAM2: view

Animal Models for DAAM2 Gene

MGI Knock Outs for DAAM2:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAAM2 Gene

Localization for DAAM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAAM2 Gene COMPARTMENTS Subcellular localization image for DAAM2 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DAAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with DAAM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DAAM2 Gene

Pathways & Interactions for DAAM2 Gene

genes like me logo Genes that share pathways with DAAM2: view

Pathways by source for DAAM2 Gene

1 KEGG pathway for DAAM2 Gene
1 Qiagen pathway for DAAM2 Gene

Gene Ontology (GO) - Biological Process for DAAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007368 determination of left/right symmetry IEA --
GO:0016043 cellular component organization IEA --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with DAAM2: view

No data available for SIGNOR curated interactions for DAAM2 Gene

Transcripts for DAAM2 Gene

Unigene Clusters for DAAM2 Gene

Dishevelled associated activator of morphogenesis 2:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAAM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3:
SP4:
SP5:
SP6: - - - - - -
SP7:
SP8: - - - - - - - -
SP9: - - - - - -
SP10:
SP11: - - - -
SP12: - - - - - -
SP13: - - - - -
SP14:
SP15:
SP16:
SP17:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b · 27c ^ 28 ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for DAAM2 Gene

GeneLoc Exon Structure for
DAAM2
ECgene alternative splicing isoforms for
DAAM2

Expression for DAAM2 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for DAAM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAAM2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.7).

Protein differential expression in normal tissues from HIPED for DAAM2 Gene

This gene is overexpressed in Spinal cord (29.8) and Frontal cortex (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for DAAM2 Gene



NURSA nuclear receptor signaling pathways regulating expression of DAAM2 Gene:

DAAM2

SOURCE GeneReport for Unigene cluster for DAAM2 Gene:

Hs.357128

mRNA Expression by UniProt/SwissProt for DAAM2 Gene:

Q86T65-DAAM2_HUMAN
Tissue specificity: Expressed in most tissues examined.
genes like me logo Genes that share expression patterns with DAAM2: view

Primer Products

No data available for Protein tissue co-expression partners for DAAM2 Gene

Orthologs for DAAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DAAM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAAM2 34 35
  • 98.52 (n)
dog
(Canis familiaris)
Mammalia DAAM2 34 35
  • 91.81 (n)
cow
(Bos Taurus)
Mammalia DAAM2 34 35
  • 91.24 (n)
rat
(Rattus norvegicus)
Mammalia Daam2 34
  • 87.34 (n)
oppossum
(Monodelphis domestica)
Mammalia DAAM2 35
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Daam2 34 16 35
  • 86.69 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DAAM2 35
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAAM2 34 35
  • 75.27 (n)
lizard
(Anolis carolinensis)
Reptilia DAAM2 35
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii daam2 35
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:114D9.2 36
  • 44 (a)
DAAM 35
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F56E10.2 36
  • 33 (a)
daam-1 35
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 50 (a)
OneToMany
Species where no ortholog for DAAM2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DAAM2 Gene

ENSEMBL:
Gene Tree for DAAM2 (if available)
TreeFam:
Gene Tree for DAAM2 (if available)

Paralogs for DAAM2 Gene

Paralogs for DAAM2 Gene

(5) SIMAP similar genes for DAAM2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DAAM2: view

Variants for DAAM2 Gene

Sequence variations from dbSNP and Humsavar for DAAM2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10046307 -- 39,827,353(+) CTGCA(A/G)ATCAT intron-variant, upstream-variant-2KB
rs10046308 -- 39,827,365(+) TCGGA(A/G)AAAGG intron-variant, upstream-variant-2KB
rs10046352 -- 39,829,134(+) CTTCA(C/T)GGGAT intron-variant, utr-variant-5-prime
rs1041280 -- 39,804,258(-) CAGAA(G/T)AGTCT intron-variant
rs10456475 -- 39,866,610(+) TAGAT(A/G)AAAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAAM2 Gene

Variant ID Type Subtype PubMed ID
esv2731956 CNV deletion 23290073
esv3351675 CNV duplication 20981092
esv3389616 CNV duplication 20981092
esv3446870 CNV duplication 20981092
nsv1074924 CNV deletion 25765185
nsv1142460 CNV tandem duplication 24896259
nsv462921 CNV loss 19166990
nsv509130 CNV insertion 20534489
nsv512877 CNV insertion 21212237
nsv602965 CNV loss 21841781

Variation tolerance for DAAM2 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAAM2 Gene

Human Gene Mutation Database (HGMD)
DAAM2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAAM2 Gene

Disorders for DAAM2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DAAM2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intestinal volvulus
  • twist of intestine, bowel, or colon
- elite association - COSMIC cancer census association via MalaCards
Search DAAM2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DAAM2

Genetic Association Database (GAD)
DAAM2
Human Genome Epidemiology (HuGE) Navigator
DAAM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAAM2
genes like me logo Genes that share disorders with DAAM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAAM2 Gene

Publications for DAAM2 Gene

  1. Identification and characterization of human DAAM2 gene in silico. (PMID: 12632087) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 22 64
  2. Genome-wide association study identifies five loci associated with lung function. (PMID: 20010834) Repapi E. … Tobin M.D. (Nat. Genet. 2010) 3 46 64
  3. Wnt antagonist gene polymorphisms and renal cancer. (PMID: 19562778) Hirata H. … Dahiya R. (Cancer 2009) 3 46 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. (PMID: 11779461) Habas R. … He X. (Cell 2001) 2 3 64

Products for DAAM2 Gene

Sources for DAAM2 Gene

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