Free for academic non-profit institutions. Other users need a Commercial license

Aliases for DAAM2 Gene

Aliases for DAAM2 Gene

  • Dishevelled Associated Activator Of Morphogenesis 2 2 3
  • KIAA0381 4 6
  • Dishevelled-Associated Activator Of Morphogenesis 2 3
  • Disheveled-Associated Activator Of Morphogenesis 2 3
  • DJ90A20A.1 3

External Ids for DAAM2 Gene

Previous GeneCards Identifiers for DAAM2 Gene

  • GC06P039837
  • GC06P039807
  • GC06P039535

Summaries for DAAM2 Gene

GeneCards Summary for DAAM2 Gene

DAAM2 (Dishevelled Associated Activator Of Morphogenesis 2) is a Protein Coding gene. Among its related pathways are Wnt signaling pathway (KEGG) and WNT Signaling. GO annotations related to this gene include actin binding and Rho GTPase binding. An important paralog of this gene is FMN2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAAM2 Gene

Genomics for DAAM2 Gene

Regulatory Elements for DAAM2 Gene

Genomic Location for DAAM2 Gene

Start:
39,792,366 bp from pter
End:
39,904,877 bp from pter
Size:
112,512 bases
Orientation:
Plus strand

Genomic View for DAAM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAAM2 Gene

Proteins for DAAM2 Gene

  • Protein details for DAAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T65-DAAM2_HUMAN
    Recommended name:
    Disheveled-associated activator of morphogenesis 2
    Protein Accession:
    Q86T65
    Secondary Accessions:
    • G5EA45
    • Q5T4T8
    • Q5T4U0
    • Q9NQI5
    • Q9Y4G0

    Protein attributes for DAAM2 Gene

    Size:
    1068 amino acids
    Molecular mass:
    123499 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20835.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DAAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAAM2 Gene

Proteomics data for DAAM2 Gene at MOPED

Post-translational modifications for DAAM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAAM2 Gene

Antibody Products

No data available for DME Specific Peptides for DAAM2 Gene

Domains for DAAM2 Gene

Suggested Antigen Peptide Sequences for DAAM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86T65

UniProtKB/Swiss-Prot:

DAAM2_HUMAN :
  • Q86T65
Domain:
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Contains 1 DAD (diaphanous autoregulatory) domain.
  • Contains 1 FH1 (formin homology 1) domain.
  • Contains 1 FH2 (formin homology 2) domain.
  • Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Family:
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with DAAM2: view

No data available for Gene Families for DAAM2 Gene

Function for DAAM2 Gene

Gene Ontology (GO) - Molecular Function for DAAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005488 binding --
GO:0017048 Rho GTPase binding IEA --
genes like me logo Genes that share ontologies with DAAM2: view
genes like me logo Genes that share phenotypes with DAAM2: view

Animal Model Products

miRNA for DAAM2 Gene

miRTarBase miRNAs that target DAAM2

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAAM2

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DAAM2 Gene

Localization for DAAM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAAM2 Gene COMPARTMENTS Subcellular localization image for DAAM2 gene
Compartment Confidence
cytosol 3
nucleus 2
cytoskeleton 1
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DAAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 18570454
genes like me logo Genes that share ontologies with DAAM2: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for DAAM2 Gene

Pathways for DAAM2 Gene

genes like me logo Genes that share pathways with DAAM2: view

Pathways by source for DAAM2 Gene

1 Qiagen pathway for DAAM2 Gene
1 KEGG pathway for DAAM2 Gene

Interacting Proteins for DAAM2 Gene

Gene Ontology (GO) - Biological Process for DAAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007368 determination of left/right symmetry IEA --
GO:0016043 cellular component organization --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with DAAM2: view

Transcripts for DAAM2 Gene

Unigene Clusters for DAAM2 Gene

Dishevelled associated activator of morphogenesis 2:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAAM2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAAM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3:
SP4:
SP5:
SP6: - - - - - -
SP7:
SP8: - - - - - - - -
SP9: - - - - - -
SP10:
SP11: - - - -
SP12: - - - - - -
SP13: - - - - -
SP14:
SP15:
SP16:
SP17:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b · 27c ^ 28 ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for DAAM2 Gene

GeneLoc Exon Structure for
DAAM2
ECgene alternative splicing isoforms for
DAAM2

Expression for DAAM2 Gene

mRNA expression in normal human tissues for DAAM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAAM2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (4.7).

Protein differential expression in normal tissues for DAAM2 Gene

This gene is overexpressed in Spinal cord (29.8) and Frontal cortex (16.2).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for DAAM2 Gene

SOURCE GeneReport for Unigene cluster for DAAM2 Gene Hs.357128

mRNA Expression by UniProt/SwissProt for DAAM2 Gene

Q86T65-DAAM2_HUMAN
Tissue specificity: Expressed in most tissues examined
genes like me logo Genes that share expressions with DAAM2: view

In Situ Assay Products

No data available for Expression partners for DAAM2 Gene

Orthologs for DAAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DAAM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DAAM2 35
  • 91.24 (n)
  • 96.81 (a)
DAAM2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAAM2 35
  • 91.81 (n)
  • 96.9 (a)
DAAM2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Daam2 35
  • 86.69 (n)
  • 92.03 (a)
Daam2 16
Daam2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DAAM2 35
  • 98.52 (n)
  • 98.78 (a)
DAAM2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Daam2 35
  • 87.34 (n)
  • 91.23 (a)
oppossum
(Monodelphis domestica)
Mammalia DAAM2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAAM2 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAAM2 35
  • 75.27 (n)
  • 81.88 (a)
DAAM2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DAAM2 36
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii daam2 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:114D9.2 37
  • 44 (a)
DAAM 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F56E10.2 37
  • 33 (a)
daam-1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for DAAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DAAM2 Gene

ENSEMBL:
Gene Tree for DAAM2 (if available)
TreeFam:
Gene Tree for DAAM2 (if available)

Paralogs for DAAM2 Gene

Selected SIMAP similar genes for DAAM2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DAAM2: view

Variants for DAAM2 Gene

Sequence variations from dbSNP and Humsavar for DAAM2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs184246 -- 39,794,438(-) CGAGG(C/T)GCTGG intron-variant
rs302622 -- 39,794,884(-) CCTGG(A/G)TAGTC intron-variant
rs302623 -- 39,792,965(-) AACCT(C/T)ACGGC intron-variant, upstream-variant-2KB
rs302624 -- 39,792,797(-) ACAAC(C/T)AGGGG intron-variant, upstream-variant-2KB
rs302625 -- 39,792,670(-) ACACA(C/G)AGGCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for DAAM2 Gene

Variant ID Type Subtype PubMed ID
nsv509130 CNV Insertion 20534489
esv2731956 CNV Deletion 23290073
nsv512877 CNV Insertion 21212237
nsv462921 CNV Loss 19166990

Relevant External Links for DAAM2 Gene

HapMap Linkage Disequilibrium report
DAAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAAM2 Gene

Disorders for DAAM2 Gene

(1) University of Copenhagen DISEASES for DAAM2 Gene

Relevant External Links for DAAM2

Genetic Association Database (GAD)
DAAM2
Human Genome Epidemiology (HuGE) Navigator
DAAM2
genes like me logo Genes that share disorders with DAAM2: view

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for DAAM2 Gene

Publications for DAAM2 Gene

  1. Identification and characterization of human DAAM2 gene in silico. (PMID: 12632087) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 23
  2. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9205841) Nagase T. … Ohara O. (DNA Res. 1997) 3 4
  3. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. (PMID: 11779461) Habas R. … He X. (Cell 2001) 2 3
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  5. Wnt antagonist gene polymorphisms and renal cancer. (PMID: 19562778) Hirata H. … Dahiya R. (Cancer 2009) 3 48

Products for DAAM2 Gene

Sources for DAAM2 Gene

Back to Top

Content