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DAAM2 Gene

protein-coding   GIFtS: 59
GCID: GC06P039807

Dishevelled Associated Activator Of Morphogenesis 2

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Dishevelled Associated Activator Of Morphogenesis 21 2
KIAA03813 5
dJ90A20A.12
Disheveled-Associated Activator Of Morphogenesis 22
Dishevelled-Associated Activator Of Morphogenesis 22

External Ids:    HGNC: 181431   Entrez Gene: 235002   Ensembl: ENSG000001461227   OMIM: 6066275   UniProtKB: Q86T653   

Export aliases for DAAM2 gene to outside databases

Previous GC identifers: GC06P039837 GC06P039868 GC06P039535


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for DAAM2 Gene:
DAAM2 (dishevelled associated activator of morphogenesis 2) is a protein-coding gene. GO annotations related to this gene include Rho GTPase binding and actin binding. An important paralog of this gene is DAAM1.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_007592.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the DAAM2 gene promoter:
         GR   AREB6   AML1a   GR-beta   Pax-2   GR-alpha   Pax-2a   ZIC2/Zic2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidDAAM2 promoter sequence
   Search Chromatin IP Primers for DAAM2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat DAAM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6p21.2   Ensembl cytogenetic band:  6p21.2   HGNC cytogenetic band: 6p21.1

DAAM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAAM2 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P039807:  view genomic region     (about GC identifiers)

Start:
39,760,142 bp from pter      End:
39,872,653 bp from pter
Size:
112,512 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: DAAM2_HUMAN, Q86T65 (See protein sequence)
Recommended Name: Disheveled-associated activator of morphogenesis 2  
Size: 1068 amino acids; 123499 Da
Sequence caution: Sequence=BAA20835.2; Type=Erroneous initiation;
Secondary accessions: G5EA45 Q5T4T8 Q5T4U0 Q9NQI5 Q9Y4G0
Alternative splicing: 2 isoforms:  Q86T65-3   Q86T65-4   

Explore the universe of human proteins at neXtProt for DAAM2: NX_Q86T65

Explore proteomics data for DAAM2 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See DAAM2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001188356.1  NP_056160.2  

    ENSEMBL proteins: 
     ENSP00000274867   ENSP00000381876   ENSP00000437808   ENSP00000384637  

    DAAM2 Human Recombinant Protein Products:

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    Novus Biologicals DAAM2 Protein
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    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DAAM2

     
    Search eBioscience for Proteins for DAAM2 

     
    antibodies-online proteins for DAAM2 (2 products) 

     
    antibodies-online peptides for DAAM2

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    antibodies-online antibodies for DAAM2 (28 products) 

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    Cloud-Clone Corp. ELISAs for DAAM2
    Cloud-Clone Corp. CLIAs for DAAM2
    Search eBioscience for ELISAs for DAAM2 
    antibodies-online kits for DAAM2 (4 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    Selected InterPro protein domains (see all 8):
     IPR010473 GTPase-bd
     IPR010472 FH3_dom
     IPR011989 ARM-like
     IPR015425 FH2_Formin
     IPR014767 Diaphanous_autoregulatory

    Graphical View of Domain Structure for InterPro Entry Q86T65

    ProtoNet protein and cluster: Q86T65

    2 Blocks protein domains:
    IPB003104 Actin-binding FH2
    IPB010472 Diaphanous FH3


    UniProtKB/Swiss-Prot: DAAM2_HUMAN, Q86T65
    Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This
    autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2
    domain to then nucleate and elongate nonbranched actin filaments (By similarity)
    Similarity: Belongs to the formin homology family
    Similarity: Contains 1 DAD (diaphanous autoregulatory) domain
    Similarity: Contains 1 FH1 (formin homology 1) domain
    Similarity: Contains 1 FH2 (formin homology 2) domain
    Similarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


    Find genes that share domains with DAAM2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005488binding ----
    GO:0017048Rho GTPase binding IEA--
         
    Find genes that share ontologies with DAAM2           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 1 allele(MGI details for Daam2):
     craniofacial  growth/size/body  immune system  skeleton 

    Find genes that share phenotypes with DAAM2           About GenesLikeMe

    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for DAAM2

    miRNA
    Products:
        
    miRTarBase miRNAs that target DAAM2:
    hsa-mir-18a-5p (MIRT031355), hsa-mir-19b-3p (MIRT031230)

    Block miRNA regulation of human, mouse, rat DAAM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAAM2 (see all 44):
    hsa-miR-4254 hsa-miR-1197 hsa-miR-29a hsa-miR-124 hsa-miR-1184 hsa-miR-4325 hsa-miR-133a hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidDAAM2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for DAAM2
    Predesigned siRNA for gene silencing in human, mouse, rat DAAM2

    Gene Editing
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    GenScript: all cDNA clones in your preferred vector (see all 2): DAAM2 (NM_001201427)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAAM2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for DAAM2 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAAM2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    nucleus2
    cytoskeleton1
    mitochondrion1
    peroxisome1

    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for DAAM2 About    
    See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway (KEGG)
    Wnt signaling pathway0.40
    2WNT Signaling
    WNT Signaling


    Find genes that share SuperPaths with DAAM2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for DAAM2
        WNT Signaling


    1 Kegg Pathway  (Kegg details for DAAM2):
        Wnt signaling pathway

        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for DAAM2
    Interactions:

        Search GeneGlobe Interaction Network for DAAM2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for DAAM2 (Q86T653 ENSP000003818764) via UniProtKB, MINT, STRING, and/or I2D (see all 86)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CAMKK2Q96RR43I2D: score=1 
    MDM2Q009873I2D: score=1 
    DVL1ENSP000003681694STRING: ENSP00000368169
    DVL2ENSP000000053404STRING: ENSP00000005340
    DVL3ENSP000003160544STRING: ENSP00000316054
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016043cellular component organization ----
    GO:0030036actin cytoskeleton organization IEA--

    Find genes that share ontologies with DAAM2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for DAAM2



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for DAAM2 gene (2 alternative transcripts): 
    NM_001201427.1  NM_015345.3  

    Unigene Cluster for DAAM2:

    Dishevelled associated activator of morphogenesis 2
    Hs.357128  [show with all ESTs]
    Unigene Representative Sequence: NM_015345
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000274867(uc010jxc.3 uc003oow.3) ENST00000398904 ENST00000475489
    ENST00000494405 ENST00000491083 ENST00000496787 ENST00000538976(uc003oox.3)
    ENST00000405961(uc003ooy.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat DAAM2 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate DAAM2 (see all 44):
    hsa-miR-4254 hsa-miR-1197 hsa-miR-29a hsa-miR-124 hsa-miR-1184 hsa-miR-4325 hsa-miR-133a hsa-miR-889
    SwitchGear 3'UTR luciferase reporter plasmidDAAM2 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for DAAM2
    Predesigned siRNA for gene silencing in human, mouse, rat DAAM2
    Clone
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    OriGene clones in human, mouse for DAAM2 (see all 7)
    OriGene ORF clones in mouse, rat for DAAM2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): DAAM2 (NM_001201427)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAAM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAAM2
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DAAM2
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat DAAM2
      QuantiTect SYBR Green Assays in human, mouse, rat DAAM2
      QuantiFast Probe-based Assays in human, mouse, rat DAAM2

    Additional mRNA sequence: 

    AB002379.2 AK310111.1 AK310941.1 AL833083.2 BC014275.2 BC047555.1 BC078153.1 BC128388.1 

    14 DOTS entries:

    DT.101983952  DT.91744099  DT.100048626  DT.95174580  DT.91715233  DT.100694454  DT.100000228  DT.100025782 
    DT.100638231  DT.91712887  DT.95174584  DT.97843321  DT.121366769  DT.91814233 

    Selected AceView cDNA sequences (see all 155):

    BM664836 CF130640 BF594052 AI088917 AI366006 BE383989 CB156369 BM991761 
    BC014275 AA351772 AA642518 BM722673 AL121065 BE302594 BQ708242 CD674696 
    AW513907 BM974490 Z40552 BG765111 AI375627 AW027237 BU681846 BM998829 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for DAAM2 (see all 17)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
    SP1:              -     -     -     -     -     -                       -     -     -                                                                           
    SP2:                    -     -     -     -     -                       -     -     -                                                                           
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                                                                                                                                                            

    ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b · 27c ^ 28 ^ 29 ^ 30 ^ 31
    SP1:                                                                                                                        
    SP2:                                                                                                                        
    SP3:                                                        -                                                               
    SP4:                                                        -                                                               
    SP5:                                                        -                                                               


    ECgene alternative splicing isoforms for DAAM2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    DAAM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCCTCCCCAC
    DAAM2 Expression
    About this image


    DAAM2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Myelinating Oligodendrocyte Cells Forebrain White Matter
             Cerebral Cortex
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Notochord Cells Notochord
             Notochord
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Allantois Cells Allantois
             Allantois
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Retina
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
    DAAM2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    DAAM2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.357128

    UniProtKB/Swiss-Prot: DAAM2_HUMAN, Q86T65
    Tissue specificity: Expressed in most tissues examined

        Custom PCR Arrays for DAAM2
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAAM2

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for DAAM2 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Daam21 , 5 dishevelled associated activator of morphogenesis 21, 5 86.69(n)1
    92.03(a)1
      17 (25.50 cM)5
    764411  NM_001008231.21  NP_001008232.21 
     494560225 
    chicken
    (Gallus gallus)
    Aves DAAM21 dishevelled associated activator of morphogenesis 2 75.27(n)
    81.88(a)
      421422  XM_419476.4  XP_419476.4 
    lizard
    (Anolis carolinensis)
    Reptilia DAAM26
    dishevelled associated activator of morphogenesis ...
    80(a)
    1 ↔ 1
    1(247088005-247210475)
    zebrafish
    (Danio rerio)
    Actinopterygii daam26
    dishevelled associated activator of morphogenesis ...
    70(a)
    1 ↔ 1
    17(48987116-49048646) ENSDARG00000028393
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:114D9.23 actin binding 44(a)   1F1   --
    worm
    (Caenorhabditis elegans)
    Secernentea F56E10.23   -- 33(a)   V(65432-70834)   --


    ENSEMBL Gene Tree for DAAM2 (if available)
    TreeFam Gene Tree for DAAM2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for DAAM2 gene
    DAAM12  DIAPH12  FMNL32  FHDC12  FMNL12  INF22  FMNL22  GRID2IP2  
    FMN12  DIAPH22  FMN22  DIAPH32  
    5 SIMAP similar genes for DAAM2 using alignment to 3 protein entries:     DAAM2_HUMAN (see all proteins):
    DAAM1    DIAPH1    DKFZp762B245    DIAPH3    DIAPH2

    Find genes that share paralogs with DAAM2           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for DAAM2 (see all 2125)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs3026321,2
    C,F,H--39758306(-) gggagG/Accgag 1 -- us2k13Minor allele frequency- A:0.40NA CSA 5
    rs93946291,2
    C,F,H--39758362(+) TGATCT/CTCTCT 1 -- us2k121Minor allele frequency- C:0.31NS EA NA CSA WA 2346
    rs93808951,2
    C,F,H--39758431(+) ACTTGG/ATCTCA 1 -- us2k121Minor allele frequency- A:0.27NS EA NA CSA WA 2344
    rs1859652451,2
    --39758437(+) TCTCAC/TAGCAA 1 -- us2k10--------
    rs728556041,2
    C,F--39758446(+) AATTGT/CGAGCT 1 -- us2k11Minor allele frequency- C:0.08WA 118
    rs93808961,2
    C,F--39758515(+) CAAGGG/TAGAAT 1 -- us2k18Minor allele frequency- T:0.36NA CSA EA 252
    rs768924701,2
    F--39758546(+) GAAACC/TTATTT 1 -- us2k11Minor allele frequency- T:0.04WA 118
    rs1408231531,2
    --39758729(+) CTACCA/GAGAGG 1 -- us2k10--------
    rs1497577571,2
    --39758732(+) CCGAGA/TGGCCC 1 -- us2k10--------
    rs3026311,2
    C,F--39758829(-) AGTTAC/GAGTGC 2 -- us2k11Minor allele frequency- G:0.06WA 118

    HapMap Linkage Disequilibrium report for DAAM2 (39760142 - 39872653 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for DAAM2:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2731956CNV Deletion23290073
    nsv512877CNV Insertion21212237
    nsv509130CNV Insertion20534489
    nsv462921CNV Loss19166990

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606627    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for DAAM2:
    Chondrosarcoma

    Find genes that share disorders with DAAM2           About GenesLikeMe

    Genetic Association Database (GAD): DAAM2
    Human Genome Epidemiology (HuGE) Navigator: DAAM2 (1 document)

    Export disorders for DAAM2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for DAAM2 gene, integrated from 10 sources (see all 11):
    (articles sorted by number of sources associating them with DAAM2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Identification and characterization of human DAAM2 gene in silico. (PubMed id 12632087)1, 3, 9 Katoh M. and Katoh M. (Int. J. Oncol. 2003)
    2. Genome-wide association study identifies five loci associated with lung function. (PubMed id 20010834)1, 4 Repapi E....Tobin M.D. (Nat. Genet. 2010)
    3. Wnt antagonist gene polymorphisms and renal cancer. (PubMed id 19562778)1, 4 Hirata H....Dahiya R. (Cancer 2009)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. (PubMed id 11779461)1, 3 Habas R.... He X. (Cell 2001)
    6. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9205841)1, 2 Nagase T.... Ohara O. (DNA Res. 1997)
    7. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (BMC Genomics 2007)
    8. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    9. Sequence identification of 2,375 human brain genes. (PubMed id 1538749)1 Adams M.D.... Venter J.C. (Nature 1992)
    10. WNT/PCP signaling pathway and human cancer (review). (PubMed id 16273260)9 Katoh M. (Oncol. Rep. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23500 HGNC: 18143 AceView: DAAM2 Ensembl:ENSG00000146122 euGenes: HUgn23500
    ECgene: DAAM2 Kegg: 23500 H-InvDB: DAAM2

    (According to HUGE)
    About This Section

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    HUGE: KIAA0381

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for DAAM2 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for DAAM2 gene:
    Search GeneIP for patents involving DAAM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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