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Aliases for DAAM2 Gene

Aliases for DAAM2 Gene

  • Dishevelled Associated Activator Of Morphogenesis 2 2 3 5
  • Dishevelled-Associated Activator Of Morphogenesis 2 3
  • DJ90A20A.1 3
  • KIAA0381 4

External Ids for DAAM2 Gene

Previous GeneCards Identifiers for DAAM2 Gene

  • GC06P039837
  • GC06P039807
  • GC06P039868
  • GC06P039535

Summaries for DAAM2 Gene

GeneCards Summary for DAAM2 Gene

DAAM2 (Dishevelled Associated Activator Of Morphogenesis 2) is a Protein Coding gene. Diseases associated with DAAM2 include Intestinal Volvulus. Among its related pathways are WNT Signaling and Wnt signaling pathway (KEGG). GO annotations related to this gene include binding and Rho GTPase binding. An important paralog of this gene is FMNL2.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAAM2 Gene

Genomics for DAAM2 Gene

Regulatory Elements for DAAM2 Gene

Enhancers for DAAM2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around DAAM2 on UCSC Golden Path with GeneCards custom track

Promoters for DAAM2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around DAAM2 on UCSC Golden Path with GeneCards custom track

Genomic Location for DAAM2 Gene

Chromosome:
6
Start:
39,792,298 bp from pter
End:
39,904,877 bp from pter
Size:
112,580 bases
Orientation:
Plus strand

Genomic View for DAAM2 Gene

Genes around DAAM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAAM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAAM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAAM2 Gene

Proteins for DAAM2 Gene

  • Protein details for DAAM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86T65-DAAM2_HUMAN
    Recommended name:
    Disheveled-associated activator of morphogenesis 2
    Protein Accession:
    Q86T65
    Secondary Accessions:
    • G5EA45
    • Q5T4T8
    • Q5T4U0
    • Q9NQI5
    • Q9Y4G0

    Protein attributes for DAAM2 Gene

    Size:
    1068 amino acids
    Molecular mass:
    123499 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA20835.2; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for DAAM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAAM2 Gene

Proteomics data for DAAM2 Gene at MOPED

Post-translational modifications for DAAM2 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAAM2 Gene

No data available for DME Specific Peptides for DAAM2 Gene

Domains & Families for DAAM2 Gene

Protein Domains for DAAM2 Gene

Suggested Antigen Peptide Sequences for DAAM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q86T65

UniProtKB/Swiss-Prot:

DAAM2_HUMAN :
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Belongs to the formin homology family.
Domain:
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Contains 1 DAD (diaphanous autoregulatory) domain.
  • Contains 1 FH1 (formin homology 1) domain.
  • Contains 1 FH2 (formin homology 2) domain.
  • Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Family:
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with DAAM2: view

No data available for Gene Families for DAAM2 Gene

Function for DAAM2 Gene

Gene Ontology (GO) - Molecular Function for DAAM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0017048 Rho GTPase binding IEA --
genes like me logo Genes that share ontologies with DAAM2: view
genes like me logo Genes that share phenotypes with DAAM2: view

Animal Models for DAAM2 Gene

MGI Knock Outs for DAAM2:

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAAM2 Gene

Localization for DAAM2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAAM2 Gene COMPARTMENTS Subcellular localization image for DAAM2 gene
Compartment Confidence
extracellular 5
cytosol 4
nucleus 3
mitochondrion 1
peroxisome 1

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for DAAM2 Gene

Pathways & Interactions for DAAM2 Gene

genes like me logo Genes that share pathways with DAAM2: view

Pathways by source for DAAM2 Gene

1 KEGG pathway for DAAM2 Gene
1 Qiagen pathway for DAAM2 Gene

Interacting Proteins for DAAM2 Gene

Gene Ontology (GO) - Biological Process for DAAM2 Gene

None

No data available for SIGNOR curated interactions for DAAM2 Gene

Drugs & Compounds for DAAM2 Gene

No Compound Related Data Available

Transcripts for DAAM2 Gene

Unigene Clusters for DAAM2 Gene

Dishevelled associated activator of morphogenesis 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for DAAM2 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b ^ 7a · 7b ^ 8 ^ 9a · 9b · 9c ^ 10 ^ 11a · 11b · 11c ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^
SP1: - - - - - - - - -
SP2: - - - - - - - -
SP3:
SP4:
SP5:
SP6: - - - - - -
SP7:
SP8: - - - - - - - -
SP9: - - - - - -
SP10:
SP11: - - - -
SP12: - - - - - -
SP13: - - - - -
SP14:
SP15:
SP16:
SP17:

ExUns: 19a · 19b ^ 20 ^ 21 ^ 22a · 22b ^ 23a · 23b ^ 24 ^ 25a · 25b ^ 26a · 26b ^ 27a · 27b · 27c ^ 28 ^ 29 ^ 30 ^ 31
SP1:
SP2:
SP3: -
SP4: -
SP5: -
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:
SP12:
SP13:
SP14:
SP15:
SP16:
SP17:

Relevant External Links for DAAM2 Gene

GeneLoc Exon Structure for
DAAM2
ECgene alternative splicing isoforms for
DAAM2

Expression for DAAM2 Gene

mRNA expression in normal human tissues for DAAM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for DAAM2 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x4.7).

Protein differential expression in normal tissues from HIPED for DAAM2 Gene

This gene is overexpressed in Spinal cord (29.8) and Frontal cortex (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for DAAM2 Gene



SOURCE GeneReport for Unigene cluster for DAAM2 Gene Hs.357128

mRNA Expression by UniProt/SwissProt for DAAM2 Gene

Q86T65-DAAM2_HUMAN
Tissue specificity: Expressed in most tissues examined.
genes like me logo Genes that share expression patterns with DAAM2: view

Primer Products

No data available for Protein tissue co-expression partners for DAAM2 Gene

Orthologs for DAAM2 Gene

This gene was present in the common ancestor of animals.

Orthologs for DAAM2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DAAM2 35
  • 91.24 (n)
  • 96.81 (a)
DAAM2 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAAM2 35
  • 91.81 (n)
  • 96.9 (a)
DAAM2 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Daam2 35
  • 86.69 (n)
  • 92.03 (a)
Daam2 16
Daam2 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DAAM2 35
  • 98.52 (n)
  • 98.78 (a)
DAAM2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Daam2 35
  • 87.34 (n)
  • 91.23 (a)
oppossum
(Monodelphis domestica)
Mammalia DAAM2 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAAM2 36
  • 61 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAAM2 35
  • 75.27 (n)
  • 81.88 (a)
DAAM2 36
  • 75 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DAAM2 36
  • 80 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii daam2 36
  • 70 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta EG:114D9.2 37
  • 44 (a)
DAAM 36
  • 37 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F56E10.2 37
  • 33 (a)
daam-1 36
  • 32 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 50 (a)
OneToMany
Species with no ortholog for DAAM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for DAAM2 Gene

ENSEMBL:
Gene Tree for DAAM2 (if available)
TreeFam:
Gene Tree for DAAM2 (if available)

Paralogs for DAAM2 Gene

Paralogs for DAAM2 Gene

(5) SIMAP similar genes for DAAM2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with DAAM2: view

Variants for DAAM2 Gene

Sequence variations from dbSNP and Humsavar for DAAM2 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs6919807 - 39,864,488(+) CGACC(A/G/T)CATCA reference, missense
rs34699846 - 39,883,966(+) GGAGC(A/G)TGTCC reference, missense
rs1041280 -- 39,804,258(-) CAGAA(G/T)AGTCT intron-variant
rs5875688 -- 39,887,718(+) CTGGA(-/TGGA)ACTGT intron-variant
rs5875690 -- 39,900,747(+) CACAC(-/T)TTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAAM2 Gene

Variant ID Type Subtype PubMed ID
nsv509130 CNV Insertion 20534489
esv2731956 CNV Deletion 23290073
nsv512877 CNV Insertion 21212237
nsv462921 CNV Loss 19166990

Variation tolerance for DAAM2 Gene

Residual Variation Intolerance Score: 86.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.18; 61.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAAM2 Gene

Human Gene Mutation Database (HGMD)
DAAM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAAM2 Gene

Disorders for DAAM2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for DAAM2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
intestinal volvulus
  • twist of intestine, bowel, or colon
- elite association - COSMIC cancer census association via MalaCards
Search DAAM2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for DAAM2

Genetic Association Database (GAD)
DAAM2
Human Genome Epidemiology (HuGE) Navigator
DAAM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAAM2
genes like me logo Genes that share disorders with DAAM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for DAAM2 Gene

Publications for DAAM2 Gene

  1. Identification and characterization of human DAAM2 gene in silico. (PMID: 12632087) Katoh M. … Katoh M. (Int. J. Oncol. 2003) 2 3 23 67
  2. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. (PMID: 11779461) Habas R. … He X. (Cell 2001) 2 3
  3. Genome-wide association analyses identify variants in developmental genes associated with hypospadias. (PMID: 25108383) Geller F. … Melbye M. (Nat. Genet. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Metastasis suppressor microRNA-335 targets the formin family of actin nucleators. (PMID: 24223803) Lynch J. … Bray I.M. (PLoS ONE 2013) 3

Products for DAAM2 Gene

Sources for DAAM2 Gene

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