Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

DAAM1 Gene

protein-coding   GIFtS: 64
GCID: GC14P059655

Dishevelled Associated Activator Of Morphogenesis 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Dishevelled Associated Activator Of Morphogenesis 11 2
KIAA06663 5
Disheveled-Associated Activator Of Morphogenesis 12

External Ids:    HGNC: 181421   Entrez Gene: 230022   Ensembl: ENSG000001005927   OMIM: 6066265   UniProtKB: Q9Y4D13   

Export aliases for DAAM1 gene to outside databases

Previous GC identifers: GC14P056979 GC14P053451 GC14P057645 GC14P058725 GC14P039819


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DAAM1 Gene:
Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the
actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The
protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in
cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during
development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is
thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This
protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the
stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct
proteins. (provided by RefSeq, Jul 2012)

GeneCards Summary for DAAM1 Gene: 
DAAM1 (dishevelled associated activator of morphogenesis 1) is a protein-coding gene. Diseases associated with DAAM1 include endotheliitis, and breast cancer, and among its related super-pathways are Wnt signaling pathway. GO annotations related to this gene include Rho GTPase binding and actin binding. An important paralog of this gene is DIAPH1.

UniProtKB/Swiss-Prot: DAAM1_HUMAN, Q9Y4D1
Function: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role
as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct
nucleation and elongation of new actin filaments

Gene Wiki entry for DAAM1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NT_026437.12  NC_018925.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the DAAM1 gene promoter:
         AML1a   AREB6   IRF-2   GATA-6   FOXO4   IRF-7A   ZIC2/Zic2   aMEF-2   Ik-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DAAM1 promoter sequence
   Search SABiosciences Chromatin IP Primers for DAAM1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAAM1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1   Ensembl cytogenetic band:  14q23.1   HGNC cytogenetic band: 14q22.3

DAAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAAM1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P059655:  view genomic region     (about GC identifiers)

Start:
59,655,364 bp from pter      End:
59,838,123 bp from pter
Size:
182,760 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: DAAM1_HUMAN, Q9Y4D1 (See protein sequence)
Recommended Name: Disheveled-associated activator of morphogenesis 1  
Size: 1078 amino acids; 123473 Da
Subunit: Homodimer. Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin,
spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA
Subcellular location: Cytoplasm. Note=Perinuclear
Sequence caution: Sequence=BAA31641.1; Type=Erroneous initiation; Sequence=BAC04230.1; Type=Erroneous initiation;
2 PDB 3D structures from and Proteopedia for DAAM1:
2J1D (3D)        2Z6E (3D)    
Secondary accessions: Q86U34 Q8N1Z8 Q8TB39
Alternative splicing: 3 isoforms:  Q9Y4D1-1   Q9Y4D1-2   Q9Y4D1-3   

Explore the universe of human proteins at neXtProt for DAAM1: NX_Q9Y4D1

Explore proteomics data for DAAM1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9Y4D1

  • DAAM1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    DAAM1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001257449.1  NP_055807.1  

    ENSEMBL proteins: 
     ENSP00000354162   ENSP00000450498   ENSP00000378557   ENSP00000247170  

    Human Recombinant Protein Products for DAAM1: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for DAAM1
    OriGene Protein Over-expression Lysate for DAAM1
    OriGene MassSpec for DAAM1 
    OriGene Custom Protein Services for DAAM1
    GenScript Custom Purified and Recombinant Proteins Services for DAAM1
    Novus Biologicals DAAM1 Protein
    Novus Biologicals DAAM1 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for DAAM1 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001725stress fiber IDA--
    GO:0005737cytoplasm IDA--
    GO:0005886plasma membrane IDA--

    DAAM1 for ontologies           About GeneDecksing



    DAAM1 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for DAAM1
    GenScript Custom Superior Antibodies Services for DAAM1
    Novus Biologicals DAAM1 Antibodies
    Abcam antibodies for DAAM1
    Cloud-Clone Corp. Antibodies for DAAM1 
    ThermoFisher Antibody for DAAM1
    LSBio Antibodies in human, mouse, rat for DAAM1 

    Assay Products for DAAM1: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for DAAM1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for DAAM1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for DAAM1 
    Cloud-Clone Corp. CLIAs for DAAM1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/8 InterPro protein domains (see all 8):
     IPR010473 Drf_GTPase-bd
     IPR010472 Drf_FH3
     IPR011989 ARM-like
     IPR015425 FH2_actin-bd
     IPR014767 Diaphanous_autoregulatory

    Graphical View of Domain Structure for InterPro Entry Q9Y4D1

    ProtoNet protein and cluster: Q9Y4D1

    2 Blocks protein domains:
    IPB003104 Actin-binding FH2
    IPB010472 Diaphanous FH3


    UniProtKB/Swiss-Prot: DAAM1_HUMAN, Q9Y4D1
    Domain: The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus
    Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This
    autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2
    domain to then nucleate and elongate nonbranched actin filaments (By similarity)
    Similarity: Belongs to the formin homology family
    Similarity: Contains 1 DAD (diaphanous autoregulatory) domain
    Similarity: Contains 1 FH1 (formin homology 1) domain
    Similarity: Contains 1 FH2 (formin homology 2) domain
    Similarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain


    DAAM1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: DAAM1_HUMAN, Q9Y4D1
    Function: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role
    as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct
    nucleation and elongation of new actin filaments

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000166nucleotide binding ----
    GO:0003779actin binding IEA--
    GO:0005488binding ----
    GO:0005515protein binding IPI16630611
    GO:0017048Rho GTPase binding IEA--
         
    DAAM1 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for DAAM1:
     Decreased focal adhesion (FA)  

         7 MGI mutant phenotypes (inferred from 1 allele(MGI details for Daam1):
     cardiovascular system  cellular  embryogenesis  growth/size  homeostasis/metabolism 
     mortality/aging  muscle 

    DAAM1 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for DAAM1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DAAM1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for DAAM1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for DAAM1 

    miRNA
    Products:
        
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAAM1
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate DAAM1 (see all 22):
    hsa-miR-3128 hsa-miR-34b* hsa-miR-218 hsa-miR-449a hsa-miR-1208 hsa-miR-613 hsa-miR-103a-2* hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidDAAM1 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DAAM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAAM1

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for DAAM1
    Sirion Biotech Customized adenovirus for overexpression of DAAM1

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for DAAM1 (see all 7)
    OriGene ORF clones in mouse, rat for DAAM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DAAM1 (NM_014992)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAAM1
    Sirion Biotech Customized lentivirus for stable overexpression of DAAM1 
                         Customized lentivirus expression plasmids for stable overexpression of DAAM1 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for DAAM1
    Search LifeMap BioReagents cell lines for DAAM1
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAAM1


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for DAAM1 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Wnt signaling pathway
    Wnt signaling pathway0.40
    Wnt Signaling Pathway NetPath0.37
    Wnt Signaling Pathway0.40
    2WNT Signaling
    WNT Signaling
    3Noncanonical Wnt signaling pathway
    Noncanonical Wnt signaling pathway

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 R&D Systems Pathway for DAAM1
        Wnt Signaling Pathway

    1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DAAM1
        WNT Signaling

    2 BioSystems Pathways for DAAM1
        Wnt Signaling Pathway NetPath
    Noncanonical Wnt signaling pathway


    1         Kegg Pathway  (Kegg details for DAAM1):
        Wnt signaling pathway


    DAAM1 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for DAAM1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

    5/51 Interacting proteins for DAAM1 (Q9Y4D11, 2, 3 ENSP000002471704) via UniProtKB, MINT, STRING, and/or I2D (see all 51)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    FNBP1LQ5T0N51, 2, 3, ENSP000002712344EBI-2817289,EBI-714058 MINT-7146145 MINT-7146222 I2D: score=1 STRING: ENSP00000271234
    RHOAP615861, 2, 3, ENSP000004001754EBI-2817289,EBI-446668 MINT-7146254 I2D: score=3 STRING: ENSP00000400175
    ABL1P005192, 3, ENSP000003614234MINT-7146345 I2D: score=1 STRING: ENSP00000361423
    BTKQ061872, 3, ENSP000003081764MINT-7146361 I2D: score=1 STRING: ENSP00000308176
    PRPF40AO754002, 3MINT-61858 I2D: score=2 
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016043cellular component organization ----
    GO:0030036actin cytoskeleton organization IEA--

    DAAM1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for DAAM1

    1 HMDB Compound for DAAM1    About this table
    CompoundSynonyms CAS #PubMed Ids
    Guanosine triphosphate5'-GTP (see all 10)86-01-1--

    Search CenterWatch for drugs/clinical trials and news about DAAM1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for DAAM1 gene (2 alternative transcripts): 
    NM_001270520.1  NM_014992.2  

    Unigene Cluster for DAAM1:

    Dishevelled associated activator of morphogenesis 1
    Hs.19156  [show with all ESTs]
    Unigene Representative Sequence: NM_001270520
    14 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556596(uc001xdy.3) ENST00000360909(uc001xeb.1 uc001xea.1 uc001xec.1)
    ENST00000556135 ENST00000395125 ENST00000557327 ENST00000556894 ENST00000554459
    ENST00000553966 ENST00000553307 ENST00000557029 ENST00000557628 ENST00000553472
    ENST00000555651 ENST00000351081(uc001xdz.1)
    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat DAAM1
    8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate DAAM1 (see all 22):
    hsa-miR-3128 hsa-miR-34b* hsa-miR-218 hsa-miR-449a hsa-miR-1208 hsa-miR-613 hsa-miR-103a-2* hsa-miR-34c-5p
    SwitchGear 3'UTR luciferase reporter plasmidDAAM1 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for DAAM1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAAM1
    Clone
    Products:
         
    OriGene clones in human, mouse for DAAM1 (see all 7)
    OriGene ORF clones in mouse, rat for DAAM1
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: DAAM1 (NM_014992)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for DAAM1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAAM1
    Sirion Biotech Customized lentivirus for stable overexpression of DAAM1 
                         Customized lentivirus expression plasmids for stable overexpression of DAAM1 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for DAAM1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DAAM1
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAAM1
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAAM1

    Additional mRNA sequence: 

    AB014566.1 AK021890.1 AK093813.1 AK123651.1 AK291790.1 AL050013.1 BC024781.1 BC038428.1 
    BC064999.1 BX247986.1 

    10 DOTS entries:

    DT.452909  DT.97839555  DT.95268185  DT.316327  DT.101978875  DT.100669228  DT.70103627  DT.100795585 
    DT.100692624  DT.120730495 

    24/260 AceView cDNA sequences (see all 260):

    AI270521 BM841491 BE220184 BF512229 CD172041 AL043290 AW612781 CA429823 
    AA278826 BF432508 AI453010 AV701694 N34880 BE818918 AI800215 AB014566 
    AA677452 AI659015 AW090763 BE884438 AL050013 BQ026874 BG940741 AA278828 

    GeneLoc Exon Structure

    5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DAAM1 (see all 8)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
    SP1:                          -           -     -     -     -     -     -     -     -     -     -     -     -     -     -     -     -                           
    SP2:                                                                                                                                                            
    SP3:                                                                                                                                                            
    SP4:                                                                                                                                                            
    SP5:                          -                       -                                                                                                         

    ExUns: 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26
    SP1:                                                        -                     
    SP2:                          -     -                 -     -                     
    SP3:                                                                              
    SP4:                                                                              
    SP5:                                                                              


    ECgene alternative splicing isoforms for DAAM1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    DAAM1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTTTTTTAAA
    DAAM1 Expression
    About this image


    See DAAM1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for DAAM1

    SOURCE GeneReport for Unigene cluster: Hs.19156

    UniProtKB/Swiss-Prot: DAAM1_HUMAN, Q9Y4D1
    Tissue specificity: Expressed in all tissues examined

        SABiosciences Expression via Pathway-Focused PCR Array including DAAM1: 
              WNT Signaling Pathway in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for DAAM1
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat DAAM1
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAAM1
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAAM1
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAAM1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for DAAM1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Daam11 , 5 dishevelled associated activator of morphogenesis 1 less1, 5 89.11(n)1
    97.21(a)1
      12 (30.06 cM)5
    2088461  NM_172464.21  NP_766052.21 
     718310785 
    chicken
    (Gallus gallus)
    Aves DAAM11 dishevelled associated activator of morphogenesis 1 less 81.19(n)
    92.94(a)
      423532  NM_001193624.1  NP_001180553.1 
    lizard
    (Anolis carolinensis)
    Reptilia DAAM16
    dishevelled associated activator of morphogenesis ...
    91(a)
    1 ↔ 1
    GL343261.1(1616999-1732619)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.251422 Xenopus laevis transcribed sequence with weak similarity to protein spO60610 (H.sapiens) DIA1_HUMAN Diaphanous protein homolog 1 (Diaphanous-related formin 1) (DRF1) less 80.05(n)    BX852108.1 
    zebrafish
    (Danio rerio)
    Actinopterygii daam1b1 dishevelled associated activator of morphogenesis 1b less 73.39(n)
    82.91(a)
      560060  NM_001030136.2  NP_001025307.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta EG:114D9.23
    DAAM1
    actin binding3
    Dishevelled Associated Activator of Morphogenesis1
    47(a)3
    54.12(n)1
    52.22(a)1
      1F13
    310751  NM_001201593.11  NP_001188522.11 
    worm
    (Caenorhabditis elegans)
    Secernentea F56E10.23
    daam-11
    Protein DAAM-11 34(a)3
    46.74(n)1
    36.77(a)1
      V(65432-70834)3
    1863921  NM_070731.31  NP_503132.21 


    ENSEMBL Gene Tree for DAAM1 (if available)
    TreeFam Gene Tree for DAAM1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for DAAM1 gene
    DIAPH12  FMNL32  FHDC12  FMNL12  DAAM22  INF22  FMNL22  GRID2IP2  
    FMN12  DIAPH22  FMN22  DIAPH32  
    3 SIMAP similar genes for DAAM1 using alignment to 2 protein entries:     DAAM1_HUMAN (see all proteins):
    DAAM2    DIAPH2    DIAPH3

    DAAM1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/3564 SNPs in DAAM1 are shown (see all 3564)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs344196771,2
    C,F--39894261(+) GAGAAGGA/-GAAGA 2 -- int12Minor allele frequency- -:0.50NA CSA 4
    rs105539071,2
    C--39909501(+) AAACA-/GAATTTT 2 -- int11Minor allele frequency- GA:0.00NA 2
    rs1928736631,2
    C--59653545(+) GAAAGG/TCTCCA 1 -- us2k10--------
    rs733130871,2
    C,F--59653685(+) CACCAT/CGAACT 1 -- us2k13Minor allele frequency- C:0.15WA CSA 122
    rs1167525691,2
    F--59653727(+) TATCAG/ATGATT 1 -- us2k11Minor allele frequency- A:0.01WA 118
    rs14385211,2
    C,F,O,A,H--59653800(-) CTTCCA/GTTTCA 1 -- us2k199Minor allele frequency- G:0.06NS NA EA PA EU CA WA CSA 6101
    rs14385201,2
    C,F,H--59653810(-) TCAGCT/AACTTC 1 -- us2k14Minor allele frequency- A:0.03NS WA NA 456
    rs1837807251,2
    --59653982(+) TAAATA/GTTTTT 1 -- us2k10--------
    rs58090201,2
    C--59654037(+) ATGAT-/AA    
       A
    /AAG
    AAGAG
    2 -- cds10--------
    rs2007387511,2
    C--59654037(-) CTCTTA/CTCATT 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for DAAM1 (59655364 - 59838123 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for DAAM1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2748746CNV Deletion23290073
    esv270189CNV Insertion20981092
    nsv507753CNV Insertion20534489
    esv268618CNV Insertion20981092
    nsv832810CNV Loss17160897
    nsv85457CNV Loss16902084
    nsv527284CNV Loss19592680
    nsv832809CNV Gain17160897


    Human Gene Mutation Database (HGMD): DAAM1
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing DAAM1
    DNA2.0 Custom Variant and Variant Library Synthesis for DAAM1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 606626    OMIM disorders: --

    2 diseases for DAAM1:    About MalaCards
    endotheliitis    breast cancer


    DAAM1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): DAAM1
    Human Genome Epidemiology (HuGE) Navigator: DAAM1 (2 documents)

    Export disorders for DAAM1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for DAAM1 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with DAAM1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. (PubMed id 11779461)1, 2, 3 Habas R.... He X. (2001)
    2. Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. (PubMed id 17482208)1, 2, 9 Lu J....Eck M.J. (2007)
    3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    4. Mechanism of activation of the Formin protein Daam1. (PubMed id 18162551)1, 3 Liu W....Habas R. (2008)
    5. The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. (PubMed id 16630611)1, 2 Aspenstroem P.... Johansson A.-S. (2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    8. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)
    9. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)1, 2 Ishikawa K.... Ohara O. (1998)
    10. Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets. (PubMed id 18218625)1, 9 Higashi T....Horiuchi H. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23002 HGNC: 18142 AceView: DAAM1 Ensembl:ENSG00000100592 euGenes: HUgn23002
    ECgene: DAAM1 Kegg: 23002 H-InvDB: DAAM1

    (According to HUGE)
    About This Section
    HUGE: KIAA0666

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for DAAM1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for DAAM1 gene:
    Search GeneIP for patents involving DAAM1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for DAAM1  
     Browse OriGene qPCR primer pairs and template standards   OriGene Protein Over-expression Lysate for DAAM1  
     OriGene MassSpec something-or-other for DAAM1   OriGene clones in human, mouse for DAAM1  
     OriGene qSTAR qPCR primer pairs in human, mouse for DAAM1   OriGene Purified Protein for DAAM1  
     OriGene ORF clones in mouse, rat for DAAM1   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for DAAM1   OriGene Custom Protein Services for DAAM1  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat DAAM1
     QIAGEN SeqTarget long-range PCR primers for resequencing DAAM1
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAAM1
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat DAAM1
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAAM1
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat DAAM1
     GenScript Custom Purified and Recombinant Proteins Services for DAAM1 GenScript cDNA clones with any tag delivered in your preferred vector for DAAM1
     GenScript Custom Assay Services for DAAM1 GenScript Custom Superior Antibodies Services for DAAM1
     GenScript Custom overexpressing Cell Line Services for DAAM1 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in DAAM1 promoter
     Search Chromatin IP Primers for DAAM1
     RT2 qPCR Primer Assay in human, mouse, rat DAAM1
     GNC Network for DAAM1
     SABiosciences PCR Arrays including human, mouse, rat DAAM1
     Search Tocris compounds for DAAM1
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     DAAM1 antibodies
     DAAM1 proteins
     DAAM1 lysates
     Antibodies for DAAM1
     See all of Abcam's Antibodies, Kits and Proteins for DAAM1
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for DAAM1
     Antibodies for DAAM1
     ELISAs for DAAM1
     CLIAs for DAAM1
     Search LifeMap BioReagents cell lines for DAAM1
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAAM1
     SwitchGear 3'UTR luciferase reporter plasmids for DAAM1
     SwitchGear Promoter luciferase reporter plasmids for DAAM1
     ThermoFisher Antibody for DAAM1
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat DAAM1
     inGenious Targeting Laboratory - Custom generated mouse model solutions for DAAM1
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for DAAM1
    Customized:
     lentivirus for stable overexpression of DAAM1
     lentivirus expression plasmids for stable overexpression of DAAM1
     adenovirus for overexpression of DAAM1
     LSBio Antibodies in human, mouse, rat for DAAM1
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      DAAM1 gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4