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Aliases for DAAM1 Gene

Aliases for DAAM1 Gene

  • Dishevelled Associated Activator Of Morphogenesis 1 2 3 5
  • KIAA0666 4

External Ids for DAAM1 Gene

Previous GeneCards Identifiers for DAAM1 Gene

  • GC14P056979
  • GC14P053451
  • GC14P057645
  • GC14P058725
  • GC14P059655
  • GC14P039819

Summaries for DAAM1 Gene

Entrez Gene Summary for DAAM1 Gene

  • Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]

GeneCards Summary for DAAM1 Gene

DAAM1 (Dishevelled Associated Activator Of Morphogenesis 1) is a Protein Coding gene. Among its related pathways are Wnt Signaling Pathway and Pluripotency and Association Between Physico-Chemical Features and Toxicity Associated Pathways. GO annotations related to this gene include identical protein binding and binding. An important paralog of this gene is DAAM2.

UniProtKB/Swiss-Prot for DAAM1 Gene

  • Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity).

Gene Wiki entry for DAAM1 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAAM1 Gene

Genomics for DAAM1 Gene

Regulatory Elements for DAAM1 Gene

Enhancers for DAAM1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G059359 1.5 Ensembl ENCODE dbSUPER 15.8 +174.3 174300 5.9 HDGF ATF1 SIN3A TCF12 GATA2 FOS ZHX2 JUNB REST TBX21 L3HYPDH DAAM1 JKAMP RTN1 GC14P059386 GC14P059252
GH14G059332 1.5 FANTOM5 Ensembl ENCODE dbSUPER 15.8 +145.0 144972 2.4 RFX1 JUN CEBPB RAD21 JUND ATF3 RFX3 GATA2 HNF4A FOS DAAM1 L3HYPDH RTN1 GPR135 GC14P059386 GC14P059252
GH14G059305 1.4 Ensembl ENCODE dbSUPER 14.7 +117.8 117774 2.7 INSM2 FEZF1 RARA ZEB1 GATA4 ZNF366 GATA2 ZSCAN5C FOS CREM DAAM1 L3HYPDH RTN1 GC14P059252 GC14P059386
GH14G059295 1.2 ENCODE dbSUPER 15.2 +108.2 108248 1.8 FOXA2 ATF1 YY1 MIER2 PPARG KAT8 ZNF579 RCOR2 KDM1A HNF4A DAAM1 L3HYPDH GC14P059252 GC14P059386
GH14G059312 1.2 ENCODE dbSUPER 14.8 +126.3 126348 5.4 ELF3 FOXA2 MLX ARID4B ZSCAN9 RAD21 RARA KAT2B YY1 FOS DAAM1 L3HYPDH RTN1 GC14P059252 GC14P059386
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around DAAM1 on UCSC Golden Path with GeneCards custom track

Promoters for DAAM1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000069127 390 2800 HDGF PKNOX1 WRNIP1 ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF766 ZNF143

Genomic Location for DAAM1 Gene

Chromosome:
14
Start:
59,188,611 bp from pter
End:
59,371,405 bp from pter
Size:
182,795 bases
Orientation:
Plus strand

Genomic View for DAAM1 Gene

Genes around DAAM1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
DAAM1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for DAAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAAM1 Gene

Proteins for DAAM1 Gene

  • Protein details for DAAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4D1-DAAM1_HUMAN
    Recommended name:
    Disheveled-associated activator of morphogenesis 1
    Protein Accession:
    Q9Y4D1
    Secondary Accessions:
    • Q86U34
    • Q8N1Z8
    • Q8TB39

    Protein attributes for DAAM1 Gene

    Size:
    1078 amino acids
    Molecular mass:
    123473 Da
    Quaternary structure:
    • Homodimer. Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA. Interacts with INTU; INTU mediates the indirect interaction between DAAM1 and NPHP4.
    SequenceCaution:
    • Sequence=BAA31641.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04230.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DAAM1 Gene

    Alternative splice isoforms for DAAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAAM1 Gene

Post-translational modifications for DAAM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAAM1 Gene

No data available for DME Specific Peptides for DAAM1 Gene

Domains & Families for DAAM1 Gene

Suggested Antigen Peptide Sequences for DAAM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4D1

UniProtKB/Swiss-Prot:

DAAM1_HUMAN :
  • The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus.
  • Belongs to the formin homology family.
Domain:
  • The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus.
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
Family:
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with DAAM1: view

No data available for Gene Families for DAAM1 Gene

Function for DAAM1 Gene

Molecular function for DAAM1 Gene

UniProtKB/Swiss-Prot Function:
Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments. Involved in building functional cilia (PubMed:16630611, PubMed:17482208). Involved in the organization of the subapical actin network in multiciliated epithelial cells (By similarity).

Gene Ontology (GO) - Molecular Function for DAAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 16630611
GO:0017048 Rho GTPase binding IEA --
GO:0042802 identical protein binding IPI 16630611
genes like me logo Genes that share ontologies with DAAM1: view
genes like me logo Genes that share phenotypes with DAAM1: view

Animal Models for DAAM1 Gene

MGI Knock Outs for DAAM1:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for DAAM1 Gene

Localization for DAAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAAM1 Gene

Cytoplasm. Cytoplasm, cytoskeleton, cilium basal body. Note=Perinuclear.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for DAAM1 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 5
cytosol 5
extracellular 1
mitochondrion 1
peroxisome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for DAAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 20534871
GO:0005737 cytoplasm IEA --
GO:0005829 cytosol TAS --
GO:0005856 cytoskeleton IEA --
GO:0005886 plasma membrane IDA --
genes like me logo Genes that share ontologies with DAAM1: view

Pathways & Interactions for DAAM1 Gene

genes like me logo Genes that share pathways with DAAM1: view

SIGNOR curated interactions for DAAM1 Gene

Activates:
Is activated by:

Gene Ontology (GO) - Biological Process for DAAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016043 cellular component organization IEA --
GO:0030036 actin cytoskeleton organization IEA --
GO:0060071 Wnt signaling pathway, planar cell polarity pathway TAS --
genes like me logo Genes that share ontologies with DAAM1: view

Drugs & Compounds for DAAM1 Gene

(1) Drugs for DAAM1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Guanosine triphosphate Experimental Pharma 0
genes like me logo Genes that share compounds with DAAM1: view

Transcripts for DAAM1 Gene

Unigene Clusters for DAAM1 Gene

Dishevelled associated activator of morphogenesis 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAAM1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - - - - - - - - - - - - -
SP2:
SP3:
SP4:
SP5: - -
SP6: -
SP7:
SP8: -

ExUns: 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26
SP1: -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for DAAM1 Gene

GeneLoc Exon Structure for
DAAM1
ECgene alternative splicing isoforms for
DAAM1

Expression for DAAM1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for DAAM1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for DAAM1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.5), Brain (11.3), and Platelet (11.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for DAAM1 Gene



Protein tissue co-expression partners for DAAM1 Gene

NURSA nuclear receptor signaling pathways regulating expression of DAAM1 Gene:

DAAM1

SOURCE GeneReport for Unigene cluster for DAAM1 Gene:

Hs.19156

mRNA Expression by UniProt/SwissProt for DAAM1 Gene:

Q9Y4D1-DAAM1_HUMAN
Tissue specificity: Expressed in all tissues examined.

Evidence on tissue expression from TISSUES for DAAM1 Gene

  • Nervous system(4.7)
  • Liver(4.2)
  • Skin(2.5)
  • Blood(2.2)
  • Heart(2.1)
genes like me logo Genes that share expression patterns with DAAM1: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for DAAM1 Gene

Orthologs for DAAM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DAAM1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia DAAM1 34 35
  • 98.3 (n)
dog
(Canis familiaris)
Mammalia DAAM1 34 35
  • 93.63 (n)
oppossum
(Monodelphis domestica)
Mammalia DAAM1 35
  • 93 (a)
OneToOne
cow
(Bos Taurus)
Mammalia DAAM1 34 35
  • 92.84 (n)
mouse
(Mus musculus)
Mammalia Daam1 34 16 35
  • 89.04 (n)
rat
(Rattus norvegicus)
Mammalia Daam1 34
  • 88.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia DAAM1 35
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAAM1 34 35
  • 80.79 (n)
lizard
(Anolis carolinensis)
Reptilia DAAM1 35
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia daam1 34
  • 79.49 (n)
Str.9426 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25142 34
zebrafish
(Danio rerio)
Actinopterygii daam1a 35
  • 80 (a)
OneToMany
daam1b 34 35
  • 74.57 (n)
fruit fly
(Drosophila melanogaster)
Insecta DAAM 34 35
  • 55.78 (n)
EG:114D9.2 36
  • 47 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003292 34
  • 52.53 (n)
worm
(Caenorhabditis elegans)
Secernentea F56E10.2 36
  • 34 (a)
daam-1 35
  • 32 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os10g0119300 34
  • 45.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 48 (a)
OneToMany
Species where no ortholog for DAAM1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAAM1 Gene

ENSEMBL:
Gene Tree for DAAM1 (if available)
TreeFam:
Gene Tree for DAAM1 (if available)

Paralogs for DAAM1 Gene

Paralogs for DAAM1 Gene

(3) SIMAP similar genes for DAAM1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DAAM1: view

Variants for DAAM1 Gene

Sequence variations from dbSNP and Humsavar for DAAM1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs142026760 Uncertain significance 59,368,683(+) AAATG(A/G)GAAAA reference, missense
rs780276345 Uncertain significance 59,352,619(+) TCCTT(C/T)TTGAG reference, missense
rs1000001867 -- 59,191,559(+) CATTT(A/C)ATCAT intron-variant
rs1000008552 -- 59,319,619(+) GGATG(A/G)AGGAT intron-variant
rs1000017860 -- 59,349,848(+) TTTAG(A/G)TAACA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAAM1 Gene

Variant ID Type Subtype PubMed ID
esv2748746 CNV deletion 23290073
esv3334876 CNV insertion 20981092
esv3374961 CNV insertion 20981092
esv3409729 CNV insertion 20981092
esv3445953 CNV insertion 20981092
nsv1050166 CNV gain 25217958
nsv1124687 CNV duplication 24896259
nsv1142170 CNV tandem duplication 24896259
nsv477976 CNV novel sequence insertion 20440878
nsv507753 OTHER sequence alteration 20534489
nsv527284 CNV loss 19592680
nsv832809 CNV gain 17160897
nsv832810 CNV loss 17160897
nsv85457 CNV deletion 16902084

Variation tolerance for DAAM1 Gene

Residual Variation Intolerance Score: 5.51% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.56; 44.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for DAAM1 Gene

Human Gene Mutation Database (HGMD)
DAAM1
SNPedia medical, phenotypic, and genealogical associations of SNPs for
DAAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAAM1 Gene

Disorders for DAAM1 Gene

Relevant External Links for DAAM1

Genetic Association Database (GAD)
DAAM1
Human Genome Epidemiology (HuGE) Navigator
DAAM1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
DAAM1

No disorders were found for DAAM1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for DAAM1 Gene

Publications for DAAM1 Gene

  1. Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. (PMID: 17482208) Lu J. … Eck M.J. (J. Mol. Biol. 2007) 3 4 22 64
  2. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. (PMID: 11779461) Habas R. … He X. (Cell 2001) 2 3 4 64
  3. The polarity protein Inturned links NPHP4 to Daam1 to control the subapical actin network in multiciliated cells. (PMID: 26644512) Yasunaga T. … Walz G. (J. Cell Biol. 2015) 3 4 64
  4. Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase. (PMID: 20223827) Higashi T. … Horiuchi H. (J. Biol. Chem. 2010) 3 22 64
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64

Products for DAAM1 Gene

Sources for DAAM1 Gene

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