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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

DAAM1 Gene

protein-coding GIFtS: 61
GCID: GC14P059655

dishevelled associated activator of morphogenesis 1

Search for DAAM1
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Dishevelled Associated Activator Of Morphogenesis 1¹ ²
KIAA0666¹ ³ ⁵
Disheveled-Associated Activator Of Morphogenesis 1²

External Ids:	HGNC: 18142¹	Entrez Gene: 23002²	Ensembl: ENSG00000100592⁷	OMIM: 606626⁵	UniProtKB: Q9Y4D1³

Export aliases for DAAM1 gene to outside databases

Previous GC identifers: GC14P056979 GC14P053451 GC14P057645 GC14P058725 GC14P039819

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for DAAM1:

Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the

actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein

encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity.

A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz

signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a

scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the

nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules.

Alternative splicing results in multiple transcript variants encoding distinct proteins. (provided by RefSeq, Jul

2012)

UniProtKB/Swiss-Prot: DAAM1_HUMAN, Q9Y4D1

Function: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a

scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and

elongation of new actin filaments

Gene Wiki entry for DAAM1

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000014.8 NC_018925.1 NT_026437.12

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the DAAM1 gene promoter:
AML1a AREB6 IRF-2 GATA-6 FOXO4 IRF-7A ZIC2/Zic2 aMEF-2 Ik-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): DAAM1 promoter sequence

Search SABiosciences Chromatin IP Primers for DAAM1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat DAAM1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q23.1 Ensembl cytogenetic band: 14q23.1 HGNC cytogenetic band: 14q22.3

DAAM1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
DAAM1 gene location

GeneLoc information about chromosome 14 GeneLoc Exon Structure

GeneLoc location for GC14P059655: view genomic region (about GC identifiers)

Start:	59,655,364 bp from pter	End:	59,838,123 bp from pter
Size:	182,760 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: DAAM1_HUMAN, Q9Y4D1 (See protein sequence)

Recommended Name: Disheveled-associated activator of morphogenesis 1

Size: 1078 amino acids; 123473 Da

Subunit: Homodimer. Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin,

spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA

Subcellular location: Cytoplasm. Note=Perinuclear

Sequence caution: Sequence=BAA31641.1; Type=Erroneous initiation; Sequence=BAC04230.1; Type=Erroneous initiation;

2 PDB 3D structures from and Proteopedia for DAAM1:

2J1D (3D)

2Z6E (3D)

Secondary accessions: Q86U34 Q8N1Z8 Q8TB39

Alternative splicing: 3 isoforms: Q9Y4D1-1 Q9Y4D1-2 Q9Y4D1-3

Explore the universe of human proteins at neXtProt for DAAM1: NX_Q9Y4D1

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q9Y4D1

DAAM1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001257449.1 NP_055807.1

ENSEMBL proteins:

ENSP00000354162 ENSP00000450498 ENSP00000378557 ENSP00000247170

Human Recombinant Protein Products for DAAM1:

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	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for DAAM1

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001725	stress fiber	IDA	--
GO:0005737	cytoplasm	IDA	--
GO:0005886	plasma membrane	IDA	--

DAAM1 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

DAAM1 for domains About GeneDecksing

5/8 InterPro domains/families (see all 8):

IPR010473 Drf_GTPase-bd

IPR010472 Drf_FH3

IPR011989 ARM-like

IPR015425 FH2_actin-bd

IPR014767 Diaphanous_autoregulatory

Graphical View of Domain Structure for InterPro Entry Q9Y4D1

ProtoNet protein and cluster: Q9Y4D1

2 Blocks protein families:

IPB003104 Actin-binding FH2

IPB010472 Diaphanous FH3

UniProtKB/Swiss-Prot: DAAM1_HUMAN, Q9Y4D1

Domain: The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus

Domain: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This

autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain

to then nucleate and elongate nonbranched actin filaments (By similarity)

Similarity: Belongs to the formin homology family

Similarity: Contains 1 DAD (diaphanous autoregulatory) domain

Similarity: Contains 1 FH1 (formin homology 1) domain

Similarity: Contains 1 FH2 (formin homology 2) domain

Similarity: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: DAAM1_HUMAN, Q9Y4D1

Function: Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a

scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and

elongation of new actin filaments

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	18218625
GO:0017048	Rho GTPase binding	IEA	--

DAAM1 for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for DAAM1:

Decreased focal adhesion (FA)

7 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Daam1):

cardiovascular system	cellular	embryogenesis	growth/size	homeostasis/metabolism
mortality/aging	muscle

DAAM1 for phenotypes About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for DAAM1

miRNA Products:		OriGene 3'-UTR Clone: DAAM1 Browse MicroRNA Expression Plasmids
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		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate DAAM1 (see all 22):
		hsa-miR-3128 hsa-miR-34b* hsa-miR-218 hsa-miR-449a hsa-miR-1208 hsa-miR-613 hsa-miR-103a-2* hsa-miR-34c-5p

		SwitchGear 3'UTR luciferase reporter plasmid: DAAM1 3' UTR sequence

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for DAAM1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Wnt Signaling Pathway

	Wnt Signaling Pathway	0.33			Wnt Signaling Pathway NetPath	0.22
	Wnt signaling pathway	0.30

WNT Signaling

WNT Signaling

1.00

Noncanonical Wnt signaling pathway

Noncanonical Wnt signaling pathway

1.00

Pathway sources
See GeneCards unified pathways
Show all pathways

1 R&D Systems Pathway for DAAM1

Wnt Signaling Pathway

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for DAAM1

WNT Signaling

2 BioSystems Pathways for DAAM1

	Wnt Signaling Pathway NetPath
	Noncanonical Wnt signaling pathway

1 Kegg Pathway (Kegg details for DAAM1):

Wnt signaling pathway

DAAM1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for DAAM1

STRING Interaction Network Preview (showing 5 interactants - click image to see 18)

5/50 Interacting proteins for DAAM1 (Q9Y4D1^{1, 2, 3} ENSP00000247170⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 50)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RHOA	P61586¹^,²^,³, ENSP00000400175⁴	EBI-2817289,EBI-446668 MINT-7146254 I2D: score=3 STRING: ENSP00000400175
FNBP1L	Q5T0N5²^,³, ENSP00000271234⁴	MINT-7146145 MINT-7146222 I2D: score=1 STRING: ENSP00000271234
ABL1	P00519²^,³, ENSP00000361423⁴	MINT-7146345 I2D: score=1 STRING: ENSP00000361423
BTK	Q06187²^,³, ENSP00000308176⁴	MINT-7146361 I2D: score=1 STRING: ENSP00000308176
PRPF40A	O75400²^,³	MINT-61858 I2D: score=2

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0030036	actin cytoskeleton organization	IEA	--

DAAM1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for DAAM1

1 HMDB Compound for DAAM1 About this table

Compound	Synonyms	CAS #	PubMed Ids
Guanosine triphosphate	5'-GTP (see all 10)	86-01-1	--

Search CenterWatch for drugs/clinical trials and news about DAAM1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for DAAM1 gene (2 alternative transcripts):

NM_001270520.1 NM_014992.2

Unigene Cluster for DAAM1:

Dishevelled associated activator of morphogenesis 1

Hs.19156 [show with all ESTs]

Unigene Representative Sequence: NM_001270520

14 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000556596(uc001xdy.3) ENST00000360909(uc001xeb.1 uc001xea.1 uc001xec.1)

ENST00000556135 ENST00000395125 ENST00000557327 ENST00000556894 ENST00000554459

ENST00000553966 ENST00000553307 ENST00000557029 ENST00000557628 ENST00000553472

ENST00000555651 ENST00000351081(uc001xdz.1)

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		8/22 QIAGEN miScript miRNA Assays for microRNAs that regulate DAAM1 (see all 22):
		hsa-miR-3128 hsa-miR-34b* hsa-miR-218 hsa-miR-449a hsa-miR-1208 hsa-miR-613 hsa-miR-103a-2* hsa-miR-34c-5p

		SwitchGear 3'UTR luciferase reporter plasmid: DAAM1 3' UTR sequence

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Additional cDNA sequence:

AB014566.1 AK021890.1 AK093813.1 AK123651.1 AK291790.1 AL050013.1 BC024781.1 BC038428.1

BC064999.1 BX247986.1

10 DOTS entries:

DT.452909 DT.97839555 DT.95268185 DT.316327 DT.101978875 DT.100669228 DT.70103627 DT.100795585

DT.100692624 DT.120730495

24/260 AceView cDNA sequences (see all 260):

CA429823 BX431669 AW612781 N27873 AW445004 F08952 AA731830 AI280147

T86662 AA889970 BI755288 AW090763 AI250181 AW449391 AA883574 N34880

BM841491 AI452880 BX498027 AI270521 BE818918 AI800215 AA487338 AL043290

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for DAAM1 (see all 8) About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	·	1e	^	2a	·	2b	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	^	6	^	7	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13	^	14	^	15	^	16	^	17	^
SP1:									-				-		-		-		-		-		-		-		-		-		-		-		-		-		-		-		-
SP2:
SP3:
SP4:
SP5:									-								-

ExUns:	18a	·	18b	^	19	^	20a	·	20b	^	21a	·	21b	^	22	^	23	^	24a	·	24b	^	25	^	26
SP1:																			-
SP2:									-		-						-		-
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for DAAM1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

DAAM1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTTTTTAAA

About this image
See DAAM1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for DAAM1

SOURCE GeneReport for Unigene cluster: Hs.19156

UniProtKB/Swiss-Prot: DAAM1_HUMAN, Q9Y4D1

Tissue specificity: Expressed in all tissues examined

SABiosciences Expression via Pathway-Focused PCR Array including DAAM1:

WNT Signaling Pathway in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat DAAM1

In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for DAAM1 gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	DAAM1¹	dishevelled associated activator of morphogenesis 1	81.19(n) 92.94(a)		423532 NM_001193624.1 NP_001180553.1
lizard (Anolis carolinensis)	Reptilia	-- --	--	95(a) 87(a)	possible ortholog possible ortholog	GL343261.1(1680896-1732579) GL343261.1(1637989-1675695)
African clawed frog (Xenopus laevis)	Amphibia	Xl.25142²	Xenopus laevis transcribed sequence with weak similarity more	80.05(n)		BX852108.1
zebrafish (Danio rerio)	Actinopterygii	daam1b¹	dishevelled associated activator of morphogenesis 1b	73.39(n) 82.91(a)		560060 NM_001030136.2 NP_001025307.1
fruit fly (Drosophila melanogaster)	Insecta	EG:114D9.2³ DAAM¹	actin binding³ Dishevelled Associated Activator of Morphogenesis¹	47(a)³ 54.12(n)¹ 52.22(a)¹		1F1³ 31075¹ NM_001201593.1¹ NP_001188522.1¹
worm (Caenorhabditis elegans)	Secernentea	F56E10.2³ daam-1¹	Protein DAAM-1¹	34(a)³ 46.74(n)¹ 36.77(a)¹		V(65432-70834)³ 186392¹ NM_070731.3¹ NP_503132.2¹
rice (Oryza sativa)	Liliopsida	-- -- (see all 3)	formin-like protein 13, putative, expressed (see all 3)	7(a) 6(a) (see all 3)	possible ortholog possible ortholog (see all 3)	7(24273183-24275962) 6(4223296-4227007)

ENSEMBL Gene Tree for DAAM1 (if available)
TreeFam Gene Tree for DAAM1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for DAAM1 gene

DIAPH1² FMNL3² FHDC1² FMNL1² FMNL2² DAAM2² INF2² GRID2IP²

FMN1² DIAPH2² DIAPH3² FMN2²

3 SIMAP similar genes for DAAM1 using alignment to 2 protein entries: DAAM1_HUMAN (see all proteins):

DAAM2 DIAPH2 DIAPH3

DAAM1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 14 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs192873663^1,2		--	59653545(+)	`GAAAGG/TCTCCA`	1	--	us2k¹		0	--	--	--	--
rs73313087^1,2	C,F	--	59653685(+)	`CACCAT/CGAACT`	1	--	us2k¹		3		WA CSA	122
rs116752569^1,2		--	59653727(+)	`TATCAG/ATGATT`	1	--	us2k¹		1		WA	118
rs1438521^1,2	C,F,O,A,H	--	59653800(-)	`CTTCCA/GTTTCA`	1	--	us2k¹		99		NS NA EA PA EU CA WA CSA	6101
rs1438520^1,2	C,F,H	--	59653810(-)	`TCAGCT/AACTTC`	1	--	us2k¹		4		NS WA NA	456
rs183780725^1,2		--	59653982(+)	`TAAATA/GTTTTT`	1	--	us2k¹		0	--	--	--	--
rs5809020^1,2	C	--	59654037(+)	`ATGAT-/AAGAAGAG`	1	--	us2k¹		0	--	--	--	--
rs200738751^1,2	C	--	59654037(-)	`CTCTTA/CTCATT`	1	--	us2k¹		0	--	--	--	--
rs142404961^1,2		--	59654138(+)	`TGGAAC/TGGGTG`	1	--	us2k¹		0	--	--	--	--
rs958043^1,2	C,F,H	--	59654200(+)	`TACATT/GTACAA`	1	--	us2k¹ tfbs³		15		NS EA NA WA	2118

HapMap Linkage Disequilibrium report for DAAM1 (59655364 - 59838123 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for DAAM1: --
Human Gene Mutation Database (HGMD): DAAM1

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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DAAM1 for disorders About MalaCards

DAAM1 for disorders About GeneDecksing

OMIM gene information: 606626 OMIM disorders: --

Human Genome Epidemiology (HuGE) Navigator: DAAM1 (2 documents)

Export disorders for DAAM1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for DAAM1 gene, integrated from 9 sources (see all 29):
(articles sorted by number of sources associating them with DAAM1)

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Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. (PubMed id 11779461)^{1, 2, 3} Habas R.... He X. (2001)
Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. (PubMed id 17482208)^{1, 2, 9} Lu J....Eck M.J. (2007)
Mechanism of activation of the Formin protein Daam1. (PubMed id 18162551)^{1, 3} Liu W....Habas R. (2008)
The diaphanous-related formin DAAM1 collaborates with the Rho GTPases RhoA and Cdc42, CIP4 and Src in regulating cell morphogenesis and actin dynamics. (PubMed id 16630611)^{1, 2} Aspenstroem P.... Johansson A.-S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)^{1, 2} Heilig R.... Weissenbach J. (2003)
Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PubMed id 9734811)^{1, 2} Ishikawa K.... Ohara O. (1998)
Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets. (PubMed id 18218625)^{1, 9} Higashi T....Horiuchi H. (2008)
Flightless-I (Fli-I) regulates the actin assembly act ivity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase. (PubMed id 20223827)^{1, 9} Higashi T....Horiuchi H. (2010)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23002	HGNC: 18142	AceView: DAAM1	Ensembl:ENSG00000100592	euGenes: HUgn23002
ECgene: DAAM1	Kegg: 23002	H-InvDB: DAAM1

(According to HUGE)
About This Section

HUGE: KIAA0666

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for DAAM1	Pharmacogenomics, SNPs, Pathways

Intellectual Property for DAAM1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for DAAM1 gene:
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dishevelled associated activator of morphogenesis 1

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DAAM1 Gene

dishevelled associated activator of morphogenesis 1

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