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Aliases for DAAM1 Gene

Aliases for DAAM1 Gene

  • Dishevelled Associated Activator Of Morphogenesis 1 2 3
  • KIAA0666 4 6

External Ids for DAAM1 Gene

Previous GeneCards Identifiers for DAAM1 Gene

  • GC14P056979
  • GC14P053451
  • GC14P057645
  • GC14P058725
  • GC14P059655
  • GC14P039819

Summaries for DAAM1 Gene

Entrez Gene Summary for DAAM1 Gene

  • Cell motility, adhesion, cytokinesis, and other functions of the cell cortex are mediated by reorganization of the actin cytoskeleton and several formin homology (FH) proteins have been associated with these processes. The protein encoded by this gene contains two FH domains and belongs to a novel FH protein subfamily implicated in cell polarity. A key regulator of cytoskeletal architecture, the small GTPase Rho, is activated during development by Wnt/Fz signaling to control cell polarity and movement. The protein encoded by this gene is thought to function as a scaffolding protein for the Wnt-induced assembly of a disheveled (Dvl)-Rho complex. This protein also promotes the nucleation and elongation of new actin filaments and regulates cell growth through the stabilization of microtubules. Alternative splicing results in multiple transcript variants encoding distinct proteins. [provided by RefSeq, Jul 2012]

GeneCards Summary for DAAM1 Gene

DAAM1 (Dishevelled Associated Activator Of Morphogenesis 1) is a Protein Coding gene. Among its related pathways are Signaling by GPCR and Wnt signaling pathway (KEGG). GO annotations related to this gene include identical protein binding and Rho GTPase binding. An important paralog of this gene is FMN2.

UniProtKB/Swiss-Prot for DAAM1 Gene

  • Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments.

Gene Wiki entry for DAAM1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for DAAM1 Gene

Genomics for DAAM1 Gene

Regulatory Elements for DAAM1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for DAAM1 Gene

Start:
59,188,611 bp from pter
End:
59,371,405 bp from pter
Size:
182,795 bases
Orientation:
Plus strand

Genomic View for DAAM1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for DAAM1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for DAAM1 Gene

Proteins for DAAM1 Gene

  • Protein details for DAAM1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y4D1-DAAM1_HUMAN
    Recommended name:
    Disheveled-associated activator of morphogenesis 1
    Protein Accession:
    Q9Y4D1
    Secondary Accessions:
    • Q86U34
    • Q8N1Z8
    • Q8TB39

    Protein attributes for DAAM1 Gene

    Size:
    1078 amino acids
    Molecular mass:
    123473 Da
    Quaternary structure:
    • Homodimer. Interacts with CIP4, FNBP1 and FNBP1L. Interacts with the SH3 domains of Abl, BTK, endophilin, spectrin and SRC. Binds specifically to GTP-bound CDC42 and RHOA.
    SequenceCaution:
    • Sequence=BAA31641.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAC04230.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for DAAM1 Gene

    Alternative splice isoforms for DAAM1 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for DAAM1 Gene

Proteomics data for DAAM1 Gene at MOPED

Post-translational modifications for DAAM1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for DAAM1 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for DAAM1 Gene

Domains for DAAM1 Gene

Suggested Antigen Peptide Sequences for DAAM1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y4D1

UniProtKB/Swiss-Prot:

DAAM1_HUMAN :
  • Q9Y4D1
Domain:
  • The C-terminal DAD domain may participate in intramolecular interactions with the N-terminus
  • The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments (By similarity).
  • Contains 1 DAD (diaphanous autoregulatory) domain.
  • Contains 1 FH1 (formin homology 1) domain.
  • Contains 1 FH2 (formin homology 2) domain.
  • Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain.
Family:
  • Belongs to the formin homology family.
genes like me logo Genes that share domains with DAAM1: view

No data available for Gene Families for DAAM1 Gene

Function for DAAM1 Gene

Molecular function for DAAM1 Gene

UniProtKB/Swiss-Prot Function:
Binds to disheveled (Dvl) and Rho, and mediates Wnt-induced Dvl-Rho complex formation. May play a role as a scaffolding protein to recruit Rho-GDP and Rho-GEF, thereby enhancing Rho-GTP formation. Can direct nucleation and elongation of new actin filaments.

Gene Ontology (GO) - Molecular Function for DAAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000166 nucleotide binding --
GO:0003779 actin binding IEA --
GO:0005488 binding --
GO:0005515 protein binding IPI 16630611
GO:0017048 Rho GTPase binding IEA --
genes like me logo Genes that share ontologies with DAAM1: view
genes like me logo Genes that share phenotypes with DAAM1: view

Animal Model Products

miRNA for DAAM1 Gene

miRTarBase miRNAs that target DAAM1

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAAM1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for DAAM1 Gene

Localization for DAAM1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for DAAM1 Gene

Cytoplasm. Note=Perinuclear.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for DAAM1 Gene COMPARTMENTS Subcellular localization image for DAAM1 gene
Compartment Confidence
cytoskeleton 5
plasma membrane 4
cytosol 3
extracellular 1
mitochondrion 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for DAAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001725 stress fiber IDA 20534871
GO:0005737 cytoplasm IDA --
GO:0005829 cytosol TAS --
GO:0005886 plasma membrane IDA --
GO:0016020 membrane IDA 19946888
genes like me logo Genes that share ontologies with DAAM1: view

Pathways for DAAM1 Gene

genes like me logo Genes that share pathways with DAAM1: view

Pathways by source for DAAM1 Gene

1 Qiagen pathway for DAAM1 Gene
1 KEGG pathway for DAAM1 Gene
1 R&D Systems pathway for DAAM1 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for DAAM1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007264 small GTPase mediated signal transduction TAS --
GO:0016043 cellular component organization --
GO:0030036 actin cytoskeleton organization IEA --
genes like me logo Genes that share ontologies with DAAM1: view

Compounds for DAAM1 Gene

(1) HMDB Compounds for DAAM1 Gene

Compound Synonyms Cas Number PubMed IDs
Guanosine triphosphate
  • 5'-GTP
86-01-1
genes like me logo Genes that share compounds with DAAM1: view

Transcripts for DAAM1 Gene

Unigene Clusters for DAAM1 Gene

Dishevelled associated activator of morphogenesis 1:
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for DAAM1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for DAAM1 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2a · 2b ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^
SP1: - - - - - - - - - - - - - - - - -
SP2:
SP3:
SP4:
SP5: - -
SP6: -
SP7:
SP8: -

ExUns: 18a · 18b ^ 19 ^ 20a · 20b ^ 21a · 21b ^ 22 ^ 23 ^ 24a · 24b ^ 25 ^ 26
SP1: -
SP2: - - - -
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:

Relevant External Links for DAAM1 Gene

GeneLoc Exon Structure for
DAAM1
ECgene alternative splicing isoforms for
DAAM1

Expression for DAAM1 Gene

mRNA expression in normal human tissues for DAAM1 Gene

Protein differential expression in normal tissues for DAAM1 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (28.5), Brain (11.3), and Platelet (11.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for DAAM1 Gene

SOURCE GeneReport for Unigene cluster for DAAM1 Gene Hs.19156

mRNA Expression by UniProt/SwissProt for DAAM1 Gene

Q9Y4D1-DAAM1_HUMAN
Tissue specificity: Expressed in all tissues examined
genes like me logo Genes that share expressions with DAAM1: view

Expression partners for DAAM1 Gene

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for DAAM1 Gene

Orthologs for DAAM1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for DAAM1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia DAAM1 35
  • 92.84 (n)
  • 98.68 (a)
DAAM1 36
  • 98 (a)
OneToOne
dog
(Canis familiaris)
Mammalia DAAM1 35
  • 93.63 (n)
  • 98.61 (a)
DAAM1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Daam1 35
  • 89.04 (n)
  • 97.28 (a)
Daam1 16
Daam1 36
  • 97 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia DAAM1 35
  • 98.3 (n)
  • 97.96 (a)
DAAM1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Daam1 35
  • 88.82 (n)
  • 97.44 (a)
oppossum
(Monodelphis domestica)
Mammalia DAAM1 36
  • 93 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia DAAM1 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves DAAM1 35
  • 80.79 (n)
  • 92.11 (a)
DAAM1 36
  • 91 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia DAAM1 36
  • 91 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia daam1 35
  • 79.49 (n)
  • 89.33 (a)
Str.9426 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.25142 35
zebrafish
(Danio rerio)
Actinopterygii daam1b 35
  • 74.57 (n)
  • 85.28 (a)
daam1a 36
  • 80 (a)
OneToMany
daam1b 36
  • 82 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta EG:114D9.2 37
  • 47 (a)
DAAM 35
  • 55.78 (n)
  • 55.38 (a)
DAAM 36
  • 37 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003292 35
  • 52.53 (n)
  • 53.1 (a)
worm
(Caenorhabditis elegans)
Secernentea F56E10.2 37
  • 34 (a)
daam-1 36
  • 32 (a)
OneToMany
rice
(Oryza sativa)
Liliopsida Os10g0119300 35
  • 45.09 (n)
  • 28.38 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 48 (a)
OneToMany
Species with no ortholog for DAAM1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for DAAM1 Gene

ENSEMBL:
Gene Tree for DAAM1 (if available)
TreeFam:
Gene Tree for DAAM1 (if available)

Paralogs for DAAM1 Gene

Selected SIMAP similar genes for DAAM1 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with DAAM1: view

Variants for DAAM1 Gene

Sequence variations from dbSNP and Humsavar for DAAM1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs15087 -- 59,370,948(+) ATAAA(A/G)GAGCA utr-variant-3-prime, nc-transcript-variant
rs721069 -- 59,220,587(+) aggcc(A/G)aggag intron-variant
rs721070 -- 59,220,390(+) CCAAC(A/G)TTTAA intron-variant
rs721326 -- 59,239,261(+) ATATA(A/C)AATAA intron-variant
rs721610 -- 59,254,854(+) CTGCT(G/T)ACATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for DAAM1 Gene

Variant ID Type Subtype PubMed ID
nsv832809 CNV Gain 17160897
esv268618 CNV Insertion 20981092
esv2748746 CNV Deletion 23290073
nsv507753 CNV Insertion 20534489
esv270189 CNV Insertion 20981092
nsv85457 CNV Loss 16902084
nsv527284 CNV Loss 19592680
nsv832810 CNV Loss 17160897

Relevant External Links for DAAM1 Gene

HapMap Linkage Disequilibrium report
DAAM1
Human Gene Mutation Database (HGMD)
DAAM1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for DAAM1 Gene

Disorders for DAAM1 Gene

Relevant External Links for DAAM1

Genetic Association Database (GAD)
DAAM1
Human Genome Epidemiology (HuGE) Navigator
DAAM1

No disorders were found for DAAM1 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships and Genatlas for DAAM1 Gene

Publications for DAAM1 Gene

  1. Structure of the FH2 domain of Daam1: implications for formin regulation of actin assembly. (PMID: 17482208) Lu J. … Eck M.J. (J. Mol. Biol. 2007) 3 4 23
  2. Wnt/Frizzled activation of Rho regulates vertebrate gastrulation and requires a novel Formin homology protein Daam1. (PMID: 11779461) Habas R. … He X. (Cell 2001) 2 3 4
  3. Biochemical characterization of the Rho GTPase-regulated actin assembly by diaphanous-related formins, mDia1 and Daam1, in platelets. (PMID: 18218625) Higashi T. … Horiuchi H. (J. Biol. Chem. 2008) 3 23
  4. Flightless-I (Fli-I) regulates the actin assembly activity of diaphanous-related formins (DRFs) Daam1 and mDia1 in cooperation with active Rho GTPase. (PMID: 20223827) Higashi T. … Horiuchi H. (J. Biol. Chem. 2010) 3 23
  5. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. (PMID: 9734811) Ishikawa K. … Ohara O. (DNA Res. 1998) 3 4

Products for DAAM1 Gene

Sources for DAAM1 Gene

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