D2HGDH Gene
protein-coding GIFtS: 57
GCID: GC02P242673
|
|
D-2-hydroxyglutarate dehydrogenase
| |
Aliases
for D2HGDH gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| D-2-Hydroxyglutarate Dehydrogenase1 2 | | D-2-Hydroxyglutarate Dehydrogenase, Mitochondrial2 | | D2HGD1 2 3 5 | | EC 1.1.99.-3 | | FLJ421951 | | EC 1.1.998 | | MGC251811 | | |
Export aliases for D2HGDH gene to outside databasesPrevious GC identifers: GC02P9M0151 GC02P242323 GC02P234429 |
Summaries
for D2HGDH gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for D2HGDH:
This gene encodes D-2hydroxyglutarate dehydrogenase, a mitochondrial enzyme belonging to the FAD-bindingoxidoreductase/transferase type 4 family. This enzyme, which is most active in liver and kidney but also active inheart and brain, converts D-2-hydroxyglutarate to 2-ketoglutarate. Mutations in this gene are present inD-2-hydroxyglutaric aciduria, a rare recessive neurometabolic disorder causing developmental delay, epilepsy,hypotonia, and dysmorphic features. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: D2HDH_HUMAN, Q8N465Function: Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarate
Gene Wiki entry for D2HGDH
|
Genomic Views
for D2HGDH gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005416.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the D2HGDH gene promoter:
AhR MyoD Pax-2 Pax-2a NF-kappaB Arnt GATA-2 GATA-1 NF-kappaB2 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for D2HGDH
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat D2HGDH |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q37.3 Ensembl cytogenetic band: 2q37.3 HGNC cytogenetic band: 2p25.3D2HGDH Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P242673: view genomic region
(about GC identifiers)
Start:
|
242,673,994 bp from pter |
End:
|
242,708,231 bp from pter |
Size:
|
34,238 bases |
Orientation:
|
plus strand |
|
Proteins
for D2HGDH gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: D2HDH_HUMAN, Q8N465 (See
protein sequence)Recommended Name: D-2-hydroxyglutarate dehydrogenase, mitochondrial precursor Size: 521 amino acids; 56416 Da
Cofactor: FAD (Potential)
Subcellular location: Mitochondrion (Probable)
Sequence caution: Sequence=AAX82020.1; Type=Erroneous gene model prediction;
Secondary accessions: Q6IQ24 Q8N5Q8Alternative splicing: 2 isoforms: Q8N465-1 Q8N465-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for D2HGDH: NX_Q8N465
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8N465
3 DME Specific Peptides for D2HGDH (Q8N465)
D2HGDH Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_689996.4
ENSEMBL proteins: ENSP00000315351 ENSP00000384723 ENSP00000400212 ENSP00000383580 ENSP00000412511 ENSP00000404596 ENSP00000392602 ENSP00000395837 ENSP00000387479 ENSP00000339536 ENSP00000442796 Reactome Protein details: Q8N465
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table
D2HGDH for ontologies About GeneDecksing
D2HGDH Antibody Products:
Assay Products for D2HGDH: |
Protein
Domains /
Families
for D2HGDH gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
D2HGDH for domains About GeneDecksing
5/7 InterPro domains/families (see all 7):Graphical View of Domain Structure for InterPro Entry Q8N465ProtoNet protein and cluster: Q8N465 1 Blocks protein family: IPB004113 FAD linked oxidase
UniProtKB/Swiss-Prot: D2HDH_HUMAN, Q8N465Similarity: Belongs to the FAD-binding oxidoreductase/transferase type 4 familySimilarity: Contains 1 FAD-binding PCMH-type domain |
Function
for D2HGDH gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: D2HDH_HUMAN, Q8N465Function: Catalyzes the oxidation of D-2-hydroxyglutarate to alpha-ketoglutarateCatalytic activity: (R)-2-hydroxyglutarate + acceptor = 2-oxoglutarate + reduced acceptorEnzyme regulation: Activated by zinc and cobaltEnzyme Numbers (IUBMB): EC 1.1.992 EC 1.1.99.-1
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for D2HGDH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for D2HGDH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: D2HGDH (NM_152783) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for D2HGDH | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat D2HGDH |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for D2HGDH |
Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008762 | UDP-N-acetylmuramate dehydrogenase activity |
IEA | -- | | GO:0050660 | flavin adenine dinucleotide binding |
IEA | -- | | GO:0051990 | (R)-2-hydroxyglutarate dehydrogenase activity |
ISS | 15070399 |
D2HGDH for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for D2HGDH:
|
Pathways & Interactions
for D2HGDH gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Interconversion of 2-oxoglutarate and 2-hydroxyglutarate | | | 2 | Metabolism | | | 3 | Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. | | | 4 | TCA Cycle | |
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for D2HGDH
D2HGDH for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for D2HGDH
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/10 Interacting proteins for D2HGDH (Q8N4651, 3 ENSP000003153514) via UniProtKB, MINT, STRING, and/or I2D (see all 10)About this table
Gene Ontology (GO): 5/8 biological process terms (GO ID links to tree view) (see all 8): About this table
D2HGDH for ontologies About GeneDecksing
|
Drugs & Compounds
for D2HGDH gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for D2HGDH
2 HMDB Compounds for D2HGDH About this table
Search CenterWatch for drugs/clinical trials and news about D2HGDH / D2HDH
|
Transcripts
for D2HGDH gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for D2HGDH gene: NM_152783.3 Unigene Cluster for D2HGDH: D-2-hydroxyglutarate dehydrogenase Hs.516813 [show with all ESTs]Unigene Representative Sequence: NM_15278318 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000321264(uc002wce.1 uc010fzq.1 uc002wcg.1) ENST00000403782
ENST00000436747(uc010zpc.1) ENST00000400769 ENST00000463932 ENST00000437164
ENST00000454048 ENST00000417686 ENST00000432449 ENST00000496252 ENST00000467427
ENST00000486953(uc002wch.3) ENST00000470343 ENST00000473126(uc002wci.2)
ENST00000468064 ENST00000445308 ENST00000342518 ENST00000537090
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for D2HGDH (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for D2HGDH
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: D2HGDH (NM_152783) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for D2HGDH | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat D2HGDH |
Additional cDNA sequence: AF318334.1 AK027102.1 AK091725.1 AK094149.1 AK304764.1 AK304773.1 AK311066.1 AK315188.1 BC031817.1 BC036604.2 11 DOTS entries: DT.92068331 DT.99969480 DT.75139555 DT.95211512 DT.108618 DT.121001808 DT.99937479 DT.100781756 DT.108617 DT.102828291 DT.121001801
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for D2HGDH (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5a | · | 5b | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | · | 13c |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | - | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | |
| SP3: | | | | | | | - | | | | | | | | | | | | - | | - | | - | | - | | | | | | - | | - | | - | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | - | | - | | | | | | | | | |
ECgene alternative splicing isoforms for D2HGDH
|
Expression
for D2HGDH gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| D2HGDH expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATGTCCAGT
About this image
See D2HGDH Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for D2HGDH
SOURCE GeneReport for Unigene cluster: Hs.516813
SABiosciences Custom PCR Arrays for D2HGDH
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for D2HGDH
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat D2HGDH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat D2HGDH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat D2HGDH | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for D2HGDH |
Orthologs
for D2HGDH gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for D2HGDH gene from 9/33 species (see all 33) About this table
ENSEMBL Gene Tree for D2HGDH (if available)
TreeFam Gene Tree for D2HGDH (if available) |
Paralogs
for D2HGDH gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for D2HGDH gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for D2HGDH (242673994 - 242708231 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 11 variations for D2HGDH
11 CNVs: 8968 32400 68301 2429 34635 79084 90414 8969 79085 34658 90413
Human Gene Mutation Database (HGMD): D2HGDH
Locus Specific Mutation Databases (LSDB): D2HGDH
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing D2HGDH |
|
Disorders
/ Diseases
for D2HGDH gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
D2HGDH for disorders About GeneDecksing
OMIM gene information: 609186
OMIM disorders: 600721
UniProtKB/Swiss-Prot: D2HDH_HUMAN, Q8N465
Defects in D2HGDH are the cause of D-2-hydroxyglutaric aciduria type 1 (D2HGA1) [MIM:600721]. D2HGA1 is a rarerecessive neurometabolic disorder causing developmental delay, epilepsy, hypotonia, and dysmorphic features. Both amild and a severe phenotype exist. The severe phenotype is homogeneous and is characterized by early infantile-onsetepileptic encephalopathy and cardiomyopathy. The mild phenotype has a more variable clinical presentation. Diagnosisis based on the presence of an excess of D-2-hydroxyglutaric acid in the urine
8  diseases for D2HGDH: About MalaCardsd-2-hydroxyglutaric aciduria 2-hydroxyglutaric aciduria hypotonia egg allergy
twinning glioblastoma tuberculosis mycobacterium tuberculosis
1 disease from the University of Copenhagen DISEASES database for D2HGDH:D-2-hydroxyglutaric aciduria Human Genome Epidemiology (HuGE) Navigator: D2HGDH (1 document)
Export disorders for D2HGDH gene to outside databases
|
Publications
for D2HGDH gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for D2HGDH gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with D2HGDH) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Mutations in the D-2-hydroxyglutarate dehydrogenase gene cause D-2-hydroxyglutaric aciduria. (PubMed id 15609246)1, 2, 3 Struys E.A....Jakobs C. (2005)
- Identification of a dehydrogenase acting on D-2-hydroxyglutarate. (PubMed id 15070399)1, 2, 3 Achouri Y....van Schaftingen E. (2004)
- D-2-Hydroxyglutaric aciduria in three patients with proven SSADH deficiency: genetic coincidence or a related biochemical epiphenomenon? (PubMed id 16442322)1, 2 Struys E.A....Jakobs C. (2006)
- Mutations in phenotypically mild D-2-hydroxyglutaric aciduria. (PubMed id 16037974)1, 2 Struys E.A.... Jakobs C. (2005)
- Phenotypic heterogeneity in the presentation of D-2-hydroxyglutaric aciduria in monozygotic twins. (PubMed id 16081310)1, 2 Misra V.K.... Innis J.W. (2005)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Screen for IDH1, IDH2, IDH3, D2HGDH and L2HGDH mutati ons in glioblastoma. (PubMed id 21625441)1 Krell D....Bardella C. (2011)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Mutational analysis of D2HGDH and L2HGDH in brain tum ours without IDH1 or IDH2 mutations. (PubMed id 20727073)1 Brehmer S....Hartmann C. (2010)
|
External Searches for D2HGDH gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing D2HGDH gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing D2HGDH gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing D2HGDH gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for D2HGDH | Pharmacogenomics, SNPs, Pathways | | GeneReviews | http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/D2HGDH |
|
| | |
About This Section
| Patent Information for D2HGDH gene:
Search GeneIP for patents involving D2HGDH
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for D2HGDH gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for D2HGDH | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for D2HGDH | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for D2HGDH | | | OriGene Protein Over-expression Lysate for D2HGDH | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for D2HGDH | | OriGene 3'-UTR Clone for D2HGDH | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for D2HGDH | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for D2HGDH | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for D2HGDH | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for D2HGDH | | OriGene Custom Protein Services for D2HGDH | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat D2HGDH | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing D2HGDH | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat D2HGDH | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat D2HGDH | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat D2HGDH | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat D2HGDH |
| |
 |  |  |  | |
| | | | Search Tocris compounds for D2HGDH |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | D2HGDH Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for D2HGDH |
|  |  |  | | | | Search ThermoFisher Antibodies for D2HGDH |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat D2HGDH |
|
|
|
|
